肿瘤相关巨噬细胞书写癌症肥胖悖论的脚本。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

BioEssays Pub Date : 2025-02-19 DOI:10.1002/bies.202400264

Anshul Sharma, Alok K. Mishra

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引用次数: 0

摘要

肥胖在促进某些免疫疗法（如抗pd -1/PD-L1）的同时，矛盾地促进了癌症的进展。Bader等人发现肥胖驱动因子增加肿瘤相关巨噬细胞（tam）上的PD-1，抑制抗肿瘤反应。值得注意的是，抗PD-1治疗逆转了这种代谢功能障碍，通过重新激活PD-1+ tam来提高免疫检查点阻断（ICB）的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tumor-Associated Macrophages Write the Script of Cancer Obesity Paradox

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Tumor-Associated Macrophages Write the Script of Cancer Obesity Paradox

Obesity paradoxically advances cancer progression while enhancing certain immunotherapies, like anti-PD-1/PD-L1. Bader et al. discovered that obesity-driven factors increase PD-1 on tumor-associated macrophages (TAMs), suppressing anti-tumor responses. Remarkably, anti-PD-1 therapy reverses this metabolic dysfunction, boosting immune checkpoint blockade (ICB) effectiveness by reactivating PD-1+ TAMs.

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来源期刊

BioEssays 生物-生化与分子生物学

CiteScore

7.30

自引率

2.50%

发文量

167

审稿时长

4-8 weeks

期刊介绍： molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.