BioEssays最新文献_第10页

New pathways to neurogenesis: Insights from injury-induced retinal regeneration 神经发生的新途径：损伤诱导视网膜再生的启示。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-07-11 DOI: 10.1002/bies.202400133

Seth Blackshaw, Jiang Qian, David R. Hyde

{"title":"New pathways to neurogenesis: Insights from injury-induced retinal regeneration","authors":"Seth Blackshaw, Jiang Qian, David R. Hyde","doi":"10.1002/bies.202400133","DOIUrl":"10.1002/bies.202400133","url":null,"abstract":"The vertebrate retina is a tractable system for studying control of cell neurogenesis and cell fate specification. During embryonic development, retinal neurogenesis is under strict temporal regulation, with cell types generated in fixed but overlapping temporal intervals. The temporal sequence and relative numbers of retinal cell types generated during development are robust and show minimal experience-dependent variation. In many cold-blooded vertebrates, acute retinal injury induces a different form of neurogenesis, where Müller glia reprogram into retinal progenitor-like cells that selectively regenerate retinal neurons lost to injury. The extent to which the molecular mechanisms controlling developmental and injury-induced neurogenesis resemble one another has long been unclear. However, a recent study in zebrafish has shed new light on this question, using single-cell multiomic analysis to show that selective loss of different retinal cell types induces the formation of fate-restricted Müller glia-derived progenitors that differ both from one another and from progenitors in developing retina. Here, we discuss the broader implications of these findings, and their possible therapeutic relevance.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 9","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The physical basis of analog-to-digital signal processing in the EGFR system—Delving into the role of the endoplasmic reticulum 表皮生长因子受体系统模拟数字信号处理的物理基础--深入探讨内质网的作用。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-07-11 DOI: 10.1002/bies.202400026

Laura Zoe Kreplin, Senthil Arumugam

{"title":"The physical basis of analog-to-digital signal processing in the EGFR system—Delving into the role of the endoplasmic reticulum","authors":"Laura Zoe Kreplin, Senthil Arumugam","doi":"10.1002/bies.202400026","DOIUrl":"10.1002/bies.202400026","url":null,"abstract":"Receptor tyrosine kinases exhibit ligand-induced activity and uptake into cells via endocytosis. In the case of epidermal growth factor (EGF) receptor (EGFR), the resulting endosomes are trafficked to the perinuclear region, where dephosphorylation of receptors occurs, which are subsequently directed to degradation. Traveling endosomes bearing phosphorylated EGFRs are subjected to the activity of cytoplasmic phosphatases as well as interactions with the endoplasmic reticulum (ER). The peri-nuclear region harbors ER-embedded phosphatases, a component of the EGFR-bearing endosome-ER contact site. The ER is also emerging as a central player in spatiotemporal control of endosomal motility, positioning, tubulation, and fission. Past studies strongly suggest that the physical interaction between the ER and endosomes forms a reaction “unit” for EGFR dephosphorylation. Independently, endosomes have been implicated to enable quantization of EGFR signals by modulation of the phosphorylation levels. Here, we review the distinct mechanisms by which endosomes form the logistical means for signal quantization and speculate on the role of the ER.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 9","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lost in translation: How neurons cope with tRNA decoding 翻译中的迷失：神经元如何应对 tRNA 解码。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-07-11 DOI: 10.1002/bies.202400107

Wei Guo, Stefano Russo, Francesca Tuorto

{"title":"Lost in translation: How neurons cope with tRNA decoding","authors":"Wei Guo, Stefano Russo, Francesca Tuorto","doi":"10.1002/bies.202400107","DOIUrl":"10.1002/bies.202400107","url":null,"abstract":"Post-transcriptional tRNA modifications contribute to the decoding efficiency of tRNAs by supporting codon recognition and tRNA stability. Recent work shows that the molecular and cellular functions of tRNA modifications and tRNA-modifying-enzymes are linked to brain development and neurological disorders. Lack of these modifications affects codon recognition and decoding rate, promoting protein aggregation and translational stress response pathways with toxic consequences to the cell. In this review, we discuss the peculiarity of local translation in neurons, suggesting a role for fine-tuning of translation performed by tRNA modifications. We provide several examples of tRNA modifications involved in physiology and pathology of the nervous system, highlighting their effects on protein translation and discussing underlying mechanisms, like the unfolded protein response (UPR), ribosome quality control (RQC), and no-go mRNA decay (NGD), which could affect neuronal functions. We aim to deepen the understanding of the roles of tRNA modifications and the coordination of these modifications with the protein translation machinery in the nervous system.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 9","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Architecture of RabL2-associated complexes at the ciliary base: A structural modeling perspective 纤毛基部与 RabL2 相关复合物的结构：结构建模视角解密纤毛RabL2复合物的结构组织

IF 3.2 3区生物学

BioEssays Pub Date : 2024-07-11 DOI: 10.1002/bies.202300222

Niels Boegholm, Narcis A. Petriman, Niaj M. Tanvir, Esben Lorentzen

{"title":"Architecture of RabL2-associated complexes at the ciliary base: A structural modeling perspective","authors":"Niels Boegholm, Narcis A. Petriman, Niaj M. Tanvir, Esben Lorentzen","doi":"10.1002/bies.202300222","DOIUrl":"10.1002/bies.202300222","url":null,"abstract":"Cilia are slender, micrometer-long organelles present on the surface of eukaryotic cells. They function in signaling and locomotion and are constructed by intraflagellar transport (IFT). The assembly of IFT complexes into so-called IFT trains to initiate ciliary entry at the base of the cilium remains a matter of debate. Here, we use structural modeling to provide an architectural framework for how RabL2 is anchored at the ciliary base via CEP19 before being handed over to IFT trains for ciliary entry. Our models suggest that the N-terminal domain of CEP43 forms a homo-dimer to anchor at the subdistal appendages of cilia through a direct interaction with CEP350. A long linker region separates the N-terminal domain of CEP43 from the C-terminal domain, which captures CEP19 above the subdistal appendages and close to the distal appendages. Furthermore, we present a structural model for how RabL2-CEP19 associates with the IFT-B complex, providing insight into how RabL2 is handed over from CEP19 to the IFT complex. Interestingly, RabL2 association with the IFT-B complex appears to induce a significant conformational change in the IFT complex via a kink in the coiled-coils of the IFT81/74 proteins, which may prime the IFT machinery for entry into cilia.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 9","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202300222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical communication between filament-forming enzymes 丝状形成酶之间的生化交流：代谢物在与 CTP 合成酶共同组装的酶中的潜在调节作用。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-07-08 DOI: 10.1002/bies.202400063

Stephen L. Bearne

{"title":"Biochemical communication between filament-forming enzymes","authors":"Stephen L. Bearne","doi":"10.1002/bies.202400063","DOIUrl":"10.1002/bies.202400063","url":null,"abstract":"A host of metabolic enzymes reversibly self-assemble to form membrane-less, intracellular filaments under normal physiological conditions and in response to stress. Often, these enzymes reside at metabolic control points, suggesting that filament formation affords an additional regulatory mechanism. Examples include cytidine-5′-triphosphate (CTP) synthase (CTPS), which catalyzes the rate-limiting step for the de novo biosynthesis of CTP; inosine-5′-monophosphate dehydrogenase (IMPDH), which controls biosynthetic access to guanosine-5′-triphosphate (GTP); and ∆1-pyrroline-5-carboxylate (P5C) synthase (P5CS) that catalyzes the formation of P5C, which links the Krebs cycle, urea cycle, and proline metabolism. Intriguingly, CTPS can exist in co-assemblies with IMPDH or P5CS. Since GTP is an allosteric activator of CTPS, the association of CTPS and IMPDH filaments accords with the need to coordinate pyrimidine and purine biosynthesis. Herein, a hypothesis is presented furnishing a biochemical connection underlying co-assembly of CTPS and P5CS filaments – potent inhibition of CTPS by glutamate γ-semialdehyde, the open-chain form of P5C.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 8","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting protein condensation in cGAS-STING signaling pathway 以 cGAS-STING 信号通路中的蛋白质缩聚为靶点。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-07-04 DOI: 10.1002/bies.202400091

Yajie Li, Dongbo Zhao, Dahua Chen, Qinmiao Sun

引用次数: 0

Metabolic channeling of lipids via the contact zones between different organelles 脂质通过不同细胞器之间的接触区进行代谢。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-06-27 DOI: 10.1002/bies.202400045

Kentaro Hanada

引用次数: 0

The concept of balance in microbiome research 微生物组研究中的平衡概念。