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Why hematopoietic stem cells fail in Fanconi anemia: Mechanisms and models 造血干细胞为何在范可尼贫血症中失效？机制与模型。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-25 DOI: 10.1002/bies.202400191
Suying Liu, ES Vivona, Peter Kurre
{"title":"Why hematopoietic stem cells fail in Fanconi anemia: Mechanisms and models","authors":"Suying Liu,&nbsp;ES Vivona,&nbsp;Peter Kurre","doi":"10.1002/bies.202400191","DOIUrl":"10.1002/bies.202400191","url":null,"abstract":"<p>Fanconi anemia (FA) is generally classified as a DNA repair disorder, conferring a genetic predisposition to cancer and prominent bone marrow failure (BMF) in early childhood. Corroborative human and murine studies point to a fetal origin of hematopoietic stem cell (HSC) attrition under replicative stress. Along with intriguing recent insights into non-canonical roles and domain-specific functions of FA proteins, these studies have raised the possibility of a DNA repair-independent BMF etiology. However, deeper mechanistic insight is critical as current curative options of allogeneic stem cell transplantation and emerging gene therapy have limited eligibility, carry significant side effects, and involve complex procedures restricted to resource-rich environments. To develop rational and broadly accessible therapies for FA patients, the field will need more faithful disease models that overcome the scarcity of patient samples, leverage technological advances, and adopt investigational clinical trial designs tailored for rare diseases.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pervasive transcription and its regulation 无处不在的转录及其调控。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-25 DOI: 10.1002/bies.202400208
Hongjia Liu, Qiong Li, Amit Sharma, Kun Luo, Hongde Liu
{"title":"Pervasive transcription and its regulation","authors":"Hongjia Liu,&nbsp;Qiong Li,&nbsp;Amit Sharma,&nbsp;Kun Luo,&nbsp;Hongde Liu","doi":"10.1002/bies.202400208","DOIUrl":"10.1002/bies.202400208","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: BioEssays 11/2024 发行信息：生物论文 11/2024
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-23 DOI: 10.1002/bies.202470018
{"title":"Issue Information: BioEssays 11/2024","authors":"","doi":"10.1002/bies.202470018","DOIUrl":"https://doi.org/10.1002/bies.202470018","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202470018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taming of the microbial beasts: Plant immunity tethers potentially pathogenic microbiota members 驯服微生物野兽：植物免疫力束缚了潜在的致病微生物群成员。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-15 DOI: 10.1002/bies.202400171
Frederickson Entila, Kenichi Tsuda
{"title":"Taming of the microbial beasts: Plant immunity tethers potentially pathogenic microbiota members","authors":"Frederickson Entila,&nbsp;Kenichi Tsuda","doi":"10.1002/bies.202400171","DOIUrl":"10.1002/bies.202400171","url":null,"abstract":"<p>Plants are in intimate association with taxonomically structured microbial communities called the plant microbiota. There is growing evidence that the plant microbiota contributes to the holistic performance and general health of plants, especially under unfavorable situations. Despite the attached benefits, surprisingly, the plant microbiota in nature also includes potentially pathogenic strains, signifying that the plant hosts have tight control over these microbes. Despite the conceivable role of plant immunity in regulating its microbiota, we lack a complete understanding of its role in governing the assembly, maintenance, and function of the plant microbiota. Here, we highlight the recent progress on the mechanistic relevance of host immunity in orchestrating plant-microbiota dialogues and discuss the pluses and perils of these microbial assemblies.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the technologies behind self-driving cars, social networks, ChatGPT, and DALL-E2 are changing structural biology 自动驾驶汽车、社交网络、ChatGPT 和 DALL-E2 背后的技术如何改变生物结构。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-15 DOI: 10.1002/bies.202400155
Matthias Bochtler
{"title":"How the technologies behind self-driving cars, social networks, ChatGPT, and DALL-E2 are changing structural biology","authors":"Matthias Bochtler","doi":"10.1002/bies.202400155","DOIUrl":"10.1002/bies.202400155","url":null,"abstract":"<p>The performance of deep Neural Networks (NNs) in the text (ChatGPT) and image (DALL-E2) domains has attracted worldwide attention. Convolutional NNs (CNNs), Large Language Models (LLMs), Denoising Diffusion Probabilistic Models (DDPMs)/Noise Conditional Score Networks (NCSNs), and Graph NNs (GNNs) have impacted computer vision, language editing and translation, automated conversation, image generation, and social network management. Proteins can be viewed as texts written with the alphabet of amino acids, as images, or as graphs of interacting residues. Each of these perspectives suggests the use of tools from a different area of deep learning for protein structural biology. Here, I review how CNNs, LLMs, DDPMs/NCSNs, and GNNs have led to major advances in protein structure prediction, inverse folding, protein design, and small molecule design. This review is primarily intended as a deep learning primer for practicing experimental structural biologists. However, extensive references to the deep learning literature should also make it relevant to readers who have a background in machine learning, physics or statistics, and an interest in protein structural biology.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ageing virus hypothesis: Epigenetic ageing beyond the Tree of Life 老化病毒假说：超越生命之树的表观遗传衰老。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-14 DOI: 10.1002/bies.202400099
Éric Bapteste
{"title":"The ageing virus hypothesis: Epigenetic ageing beyond the Tree of Life","authors":"Éric Bapteste","doi":"10.1002/bies.202400099","DOIUrl":"10.1002/bies.202400099","url":null,"abstract":"<p>A recent thought-provoking theory argues that complex organisms using epigenetic information for their normal development and functioning must irreversibly age as a result of epigenetic signal loss. Importantly, the scope of this theory could be considerably expanded, with scientific benefits, by analyzing epigenetic ageing beyond the borders of the Tree of Life. Viruses that use epigenetic signals for their normal functioning may also age, that is, present an increasing risk of failing to complete their individual life cycle and to disappear with time. As viruses are ancient, abundant, and infect a considerable diversity of hosts, the ageing virus hypothesis, if verified, would have important consequences for many fields of the Life sciences. Uncovering ageing viruses would integrate the most abundant and biologically central entities on Earth into theories of ageing, enhance virology, gerontology, evolutionary biology, molecular ecology, genomics, and possibly medicine through the development of new therapies manipulating viral ageing.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of PSC to embryos: Extending and refining capture of PSC lines from mammalian embryos 造血干细胞与胚胎的关系：扩展和完善从哺乳动物胚胎中捕获的造血干细胞系。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-14 DOI: 10.1002/bies.202400077
Qi-Long Ying, Jennifer Nichols
{"title":"Relationship of PSC to embryos: Extending and refining capture of PSC lines from mammalian embryos","authors":"Qi-Long Ying,&nbsp;Jennifer Nichols","doi":"10.1002/bies.202400077","DOIUrl":"10.1002/bies.202400077","url":null,"abstract":"<p>Pluripotent stem cell lines derived from preimplantation mouse embryos have opened opportunities for the study of early mammalian development and generation of genetically uncompromised material for differentiation into specific cell types. Murine embryonic stem cells are highly versatile and can be engineered and introduced into host embryos, transferred to recipient females, and gestated to investigate gene function at multiple levels as well as developmental mechanisms, including lineage segregation and cell competition. In this review, we summarize the biomedical motivation driving the incremental modification to culture regimes and analyses that have advanced stem cell research to its current state. Ongoing investigation into divergent mechanisms of early developmental processes adopted by other species, such as agriculturally beneficial mammals and birds, will continue to enrich knowledge and inform strategies for future in vitro models.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 12","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How bacteria initiate DNA replication comes into focus 细菌如何启动 DNA 复制成为焦点。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-10 DOI: 10.1002/bies.202400151
Fahad Rashid, James M. Berger
{"title":"How bacteria initiate DNA replication comes into focus","authors":"Fahad Rashid,&nbsp;James M. Berger","doi":"10.1002/bies.202400151","DOIUrl":"10.1002/bies.202400151","url":null,"abstract":"<p>The ability to initiate DNA replication is a critical step in the proliferation of all organisms. In bacteria, this process is mediated by an ATP-dependent replication initiator protein, DnaA, which recognizes and melts replication origin (<i>oriC</i>) elements. Despite decades of biochemical and structural work, a mechanistic understanding of how DnaA recognizes and unwinds <i>oriC</i> has remained enigmatic. A recent study by Pelliciari et al. provides important new structural insights into how DnaA from <i>Bacillus subtilis</i> recognizes and processes its cognate <i>oriC</i>, showing how DnaA uses sequence features encoded in the origin to engage melted DNA. Comparison of the DnaA-<i>oriC</i> structure with archaeal/eukaryl replication origin complexes based on Orc-family proteins reveals a high degree of similarity in origin engagement by initiators from di domains of life, despite fundamental differences in origin melting mechanisms. These findings provide valuable insights into bacterial replication initiation and highlight the intriguing evolutionary history of this fundamental biological process.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases? 线粒体功能障碍，神经退行性疾病的原因还是结果？
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-04 DOI: 10.1002/bies.202400023
Zoë P. Van Acker, Thomas Leroy, Wim Annaert
{"title":"Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?","authors":"Zoë P. Van Acker,&nbsp;Thomas Leroy,&nbsp;Wim Annaert","doi":"10.1002/bies.202400023","DOIUrl":"10.1002/bies.202400023","url":null,"abstract":"<p>Neurodegenerative diseases encompass a spectrum of conditions characterized by the gradual deterioration of neurons in the central and peripheral nervous system. While their origins are multifaceted, emerging data underscore the pivotal role of impaired mitochondrial functions and endolysosomal homeostasis to the onset and progression of pathology. This article explores whether mitochondrial dysfunctions act as causal factors or are intricately linked to the decline in endolysosomal function. As research delves deeper into the genetics of neurodegenerative diseases, an increasing number of risk loci and genes associated with the regulation of endolysosomal and autophagy functions are being identified, arguing for a downstream impact on mitochondrial health. Our hypothesis centers on the notion that disturbances in endolysosomal processes may propagate to other organelles, including mitochondria, through disrupted inter-organellar communication. We discuss these views in the context of major neurodegenerative diseases including Alzheimer's and Parkinson's diseases, and their relevance to potential therapeutic avenues.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation and signaling of the LIM domain kinases LIM 结构域激酶的调控和信号传递。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-03 DOI: 10.1002/bies.202400184
Gabriela Casanova-Sepúlveda, Titus J. Boggon
{"title":"Regulation and signaling of the LIM domain kinases","authors":"Gabriela Casanova-Sepúlveda,&nbsp;Titus J. Boggon","doi":"10.1002/bies.202400184","DOIUrl":"10.1002/bies.202400184","url":null,"abstract":"<p>The LIM domain kinases (LIMKs) are important actin cytoskeleton regulators. These proteins, LIMK1 and LIMK2, are nodes downstream of Rho GTPases and are the key enzymes that phosphorylate cofilin/actin depolymerization factors to regulate filament severing. They therefore perform an essential role in cascades that control actin depolymerization. Signaling of the LIMKs is carefully regulated by numerous inter- and intra-molecular mechanisms. In this review, we discuss recent findings that improve the understanding of LIM domain kinase regulation mechanisms. We also provide an up-to-date review of the role of the LIM domain kinases, their architectural features, how activity is impacted by other proteins, and the implications of these findings for human health and disease.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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