BioEssays最新文献_第9页

Omegasomes control formation, expansion, and closure of autophagosomes 奥米加体控制着自噬体的形成、扩展和闭合。

IF 4 3区生物学

BioEssays Pub Date : 2024-05-09 DOI: 10.1002/bies.202400038

Viola Nähse, Harald Stenmark, Kay O. Schink

{"title":"Omegasomes control formation, expansion, and closure of autophagosomes","authors":"Viola Nähse, Harald Stenmark, Kay O. Schink","doi":"10.1002/bies.202400038","DOIUrl":"10.1002/bies.202400038","url":null,"abstract":"Autophagy, an essential cellular process for maintaining cellular homeostasis and eliminating harmful cytoplasmic objects, involves the de novo formation of double-membraned autophagosomes that engulf and degrade cellular debris, protein aggregates, damaged organelles, and pathogens. Central to this process is the phagophore, which forms from donor membranes rich in lipids synthesized at various cellular sites, including the endoplasmic reticulum (ER), which has emerged as a primary source. The ER-associated omegasomes, characterized by their distinctive omega-shaped structure and accumulation of phosphatidylinositol 3-phosphate (PI3P), play a pivotal role in autophagosome formation. Omegasomes are thought to serve as platforms for phagophore assembly by recruiting essential proteins such as DFCP1/ZFYVE1 and facilitating lipid transfer to expand the phagophore. Despite the critical importance of phagophore biogenesis, many aspects remain poorly understood, particularly the complete range of proteins involved in omegasome dynamics, and the detailed mechanisms of lipid transfer and membrane contact site formation.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mRNA context and translation factors determine decoding in alternative nuclear genetic codes mRNA 上下文和翻译因子决定着替代性核遗传密码的解码。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-09 DOI: 10.1002/bies.202400058

Ali Salman, Nikita Biziaev, Ekaterina Shuvalova, Elena Alkalaeva

引用次数: 0

Advances in computational and experimental approaches for deciphering transcriptional regulatory networks 解读转录调控网络的计算和实验方法取得进展：了解顺式调控元件的作用至关重要，最近利用 MPRAs、STARR-seq、CRISPR-Cas9 和机器学习开展的研究获得了宝贵的见解。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-08 DOI: 10.1002/bies.202300210

Camille Moeckel, Ioannis Mouratidis, Nikol Chantzi, Yasin Uzun, Ilias Georgakopoulos-Soares

引用次数: 0

How are Trypanosoma brucei receptors protected from host antibody-mediated attack? 如何保护布氏锥虫受体免受宿主抗体介导的攻击？

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-07 DOI: 10.1002/bies.202400053

Sourav Banerjee, Nicola Minshall, Helena Webb, Mark Carrington

引用次数: 0

An indirect perspective to link genetic mosaicism and tumorigenesis 将基因嵌合与肿瘤发生联系起来的间接视角。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-07 DOI: 10.1002/bies.202400102

Leone Albinati, Renée Beekman

引用次数: 0

Recent insights from human induced pluripotent stem cell models into the role of microglia in amyotrophic lateral sclerosis 人类诱导多能干细胞模型对小胶质细胞在肌萎缩性脊髓侧索硬化症中作用的最新见解。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-07 DOI: 10.1002/bies.202400054

Lara M. Nikel, Kevin Talbot, Björn F. Vahsen

{"title":"Recent insights from human induced pluripotent stem cell models into the role of microglia in amyotrophic lateral sclerosis","authors":"Lara M. Nikel, Kevin Talbot, Björn F. Vahsen","doi":"10.1002/bies.202400054","DOIUrl":"10.1002/bies.202400054","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, primarily leading to the degeneration of motor neurons. The traditional focus on motor neuron-centric mechanisms has recently shifted towards understanding the contribution of non-neuronal cells, such as microglia, in ALS pathophysiology. Advances in induced pluripotent stem cell (iPSC) technology have enabled the generation of iPSC-derived microglia monocultures and co-cultures to investigate their role in ALS pathogenesis. Here, we briefly review the insights gained from these studies into the role of microglia in ALS. While iPSC-derived microglia monocultures have revealed intrinsic cellular dysfunction due to ALS-associated mutations, microglia-motor neuron co-culture studies have demonstrated neurotoxic effects of mutant microglia on motor neurons. Based on these findings, we briefly discuss currently unresolved questions and how they could be addressed in future studies. iPSC models hold promise for uncovering disease-relevant pathways in ALS and identifying potential therapeutic targets.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainability in a broad sense: An essential aspect of scientific conferences 广义上的可持续性：科学会议的一个重要方面。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-07 DOI: 10.1002/bies.202400017

Malene Brohus, Martin D. Bootman, Geert Bultynck

{"title":"Sustainability in a broad sense: An essential aspect of scientific conferences","authors":"Malene Brohus, Martin D. Bootman, Geert Bultynck","doi":"10.1002/bies.202400017","DOIUrl":"10.1002/bies.202400017","url":null,"abstract":"This article reflects on sustainability in the context of scientific conferences with emphasis on environmental, diversity, inclusivity, and intellectual aspects. We argue that it is imperative to embrace sustainability as a broad concept during conference organization. In-person conferences have an obvious environmental impact but mitigating strategies can be implemented, such as incentivizing low-emission travel, offering fellowships to support sustainable traveling, and promoting use of public transport or car-pooling. Utilizing eco-conscious venues, catering, and accommodations, along with minimizing resource wastage, further reduces environmental impact. Additional considerations include facilitating hybrid format conferences that allow both in-person and online attendance. Hybrid conferences enhance global participation whilst reducing resource consumption and environmental impact. Often-overlooked benefits can arise from the simple recording of talks to enable asynchronous viewing for people unable to attend in person, in addition to providing a legacy of knowledge that, for example, could support the training of early career researchers (ECRs) or newcomers in the field. The longevity of a research field, intellectual sustainability, requires an inclusive conference atmosphere, offering optimal opportunities for ECRs, minority groups, and researchers from emerging countries. Diversity and inclusivity not only enrich conference experiences but also enhances creativity and innovation.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavin-containing monooxygenase (FMO): Beyond xenobiotics 含黄素单氧化酶（FMO）：超越异生物。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-07 DOI: 10.1002/bies.202400029

Ajay Bhat, Faith R. Carranza, Angela M. Tuckowski, Scott F. Leiser

{"title":"Flavin-containing monooxygenase (FMO): Beyond xenobiotics","authors":"Ajay Bhat, Faith R. Carranza, Angela M. Tuckowski, Scott F. Leiser","doi":"10.1002/bies.202400029","DOIUrl":"10.1002/bies.202400029","url":null,"abstract":"Flavin-containing monooxygenases (FMOs), traditionally known for detoxifying xenobiotics, are now recognized for their involvement in endogenous metabolism. We recently discovered that an isoform of FMO, fmo-2 in Caenorhabditis elegans, alters endogenous metabolism to impact longevity and stress tolerance. Increased expression of fmo-2 in C. elegans modifies the flux through the key pathway known as One Carbon Metabolism (OCM). This modified flux results in a decrease in the ratio of S-adenosyl-methionine (SAM) to S-adenosyl-homocysteine (SAH), consequently diminishing methylation capacity. Here we discuss how FMO-2-mediated formate production during tryptophan metabolism may serve as a trigger for changing the flux in OCM. We suggest formate bridges tryptophan and OCM, altering metabolic flux away from methylation during fmo-2 overexpression. Additionally, we highlight how these metabolic results intersect with the mTOR and AMPK pathways, in addition to mitochondrial metabolism. In conclusion, the goal of this essay is to bring attention to the central role of FMO enzymes but lack of understanding of their mechanisms. We justify a call for a deeper understanding of FMO enzyme's role in metabolic rewiring through tryptophan/formate or other yet unidentified substrates. Additionally, we emphasize the identification of novel drugs and microbes to induce FMO activity and extend lifespan.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasticity mechanisms of genetically distinct Purkinje cells 基因不同的浦肯野细胞的可塑性机制

IF 4 3区生物学

BioEssays Pub Date : 2024-05-02 DOI: 10.1002/bies.202400008

Stijn Voerman, Robin Broersen, Sigrid M. A. Swagemakers, Chris I. De Zeeuw, Peter J. van der Spek

引用次数: 0

Tuning synaptic strength by regulation of AMPA glutamate receptor localization 通过调节 AMPA 谷氨酸受体定位调节突触强度

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-01 DOI: 10.1002/bies.202400006

Imogen Stockwell, Jake F. Watson, Ingo H. Greger

引用次数: 0