BioEssays最新文献_第8页

Life outside the LINC complex – Do SUN proteins have LINC-independent functions? LINC复合体之外的生命--SUN蛋白是否具有独立于LINC的功能？

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-27 DOI: 10.1002/bies.202400034

Nejma Belaadi, Christophe Guilluy

引用次数: 0

Issue Information: BioEssays 6/2024 发行信息：生物论文 6/2024

IF 4 3区生物学

BioEssays Pub Date : 2024-05-27 DOI: 10.1002/bies.202470010

引用次数: 0

Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis Entosis揭示了P53在小头畸形发病机制中除凋亡之外的新作用。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-22 DOI: 10.1002/bies.202300245

Noelle A. Sterling, Seo-Hee Cho, Seonhee Kim

{"title":"Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis","authors":"Noelle A. Sterling, Seo-Hee Cho, Seonhee Kim","doi":"10.1002/bies.202300245","DOIUrl":"10.1002/bies.202300245","url":null,"abstract":"Entosis, a form of cell cannibalism, is a newly discovered pathogenic mechanism leading to the development of small brains, termed microcephaly, in which P53 activation was found to play a major role. Microcephaly with entosis, found in Pals1 mutant mice, displays P53 activation that promotes entosis and apoptotic cell death. This previously unappreciated pathogenic mechanism represents a novel cellular dynamic in dividing cortical progenitors which is responsible for cell loss. To date, various recent models of microcephaly have bolstered the importance of P53 activation in cell death leading to microcephaly. P53 activation caused by mitotic delay or DNA damage manifests apoptotic cell death which can be suppressed by P53 removal in these animal models. Such genetic studies attest P53 activation as quality control meant to eliminate genomically unfit cells with minimal involvement in the actual function of microcephaly associated genes. In this review, we summarize the known role of P53 activation in a variety of microcephaly models and introduce a novel mechanism wherein entotic cell cannibalism in neural progenitors is triggered by P53 activation.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3 发掘 TRPV3 的治疗潜力：对涉及 TRPV3 的热感觉、通道调节和皮肤稳态的见解。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-20 DOI: 10.1002/bies.202400047

Jing Lei, Makoto Tominaga

{"title":"Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3","authors":"Jing Lei, Makoto Tominaga","doi":"10.1002/bies.202400047","DOIUrl":"10.1002/bies.202400047","url":null,"abstract":"Recent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding elucidated how thermosensation is affected by TRPV3 membrane abundance that is modulated by the transmembrane protein TMEM79. TRPV3 is a warmth-sensitive ion channel predominantly expressed in epithelial cells, particularly skin keratinocytes. Multiple studies investigated the roles of TRPV3 in cutaneous physiology and pathophysiology. TRPV3 activation by innocuous warm temperatures in keratinocytes highlights its significance in temperature sensation, but whether TRPV3 directly contributes to warmth sensations in vivo remains controversial. This review explores the electrophysiological and structural properties of TRPV3 and how modulators affect its intricate regulatory mechanisms. Moreover, we discuss the multifaceted involvement of TRPV3 in skin physiology and pathology, including barrier formation, hair growth, inflammation, and itching. Finally, we examine the potential of TRPV3 as a therapeutic target for skin diseases and highlight its diverse role in maintaining skin homeostasis.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agile Genetics: Single gene resolution without the fuss 敏捷遗传学：轻松解决单基因问题

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-20 DOI: 10.1002/bies.202300206

Justin N. Vaughn, Walid Korani, Josh Clevenger, Peggy Ozias-Akins

引用次数: 0

We can run and we can hide, but we cannot escape… Review of “The Decarbonization Delusion: What 3.5 Billion Years of Biological Sustainability can Teach us” by Andrew Moore, 2023. 我们可以逃跑，可以躲藏，但我们无法逃脱......作者：摩尔-安德鲁，评论《去碳化妄想》：35亿年的可持续发展能教会我们什么？2023.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-20 DOI: 10.1002/bies.202400084

William F. Martin

引用次数: 0

Ribosomal dormancy at the nexus of ribosome homeostasis and protein synthesis 核糖体休眠是核糖体平衡和蛋白质合成的关键。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-20 DOI: 10.1002/bies.202300247

Saloni Koli, Sunil Shetty

引用次数: 0

Angiomotin family proteins in the Hippo signaling pathway Hippo 信号通路中的 Angiomotin 家族蛋白。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-17 DOI: 10.1002/bies.202400076

Yu Wang, Fa-Xing Yu

引用次数: 0

A paREDOX in the control of cholesterol biosynthesis 胆固醇生物合成控制中的一个 "paREDOX"：NADPH 传感器和 E3 泛素连接酶 MARCHF6 是否能在氧化应激期间通过控制固醇的生物合成来保护哺乳动物细胞？

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-17 DOI: 10.1002/bies.202400073

Nicole M. Fenton, Lydia Qian, Eloise G. Paine, Laura J. Sharpe, Andrew J. Brown

{"title":"A paREDOX in the control of cholesterol biosynthesis","authors":"Nicole M. Fenton, Lydia Qian, Eloise G. Paine, Laura J. Sharpe, Andrew J. Brown","doi":"10.1002/bies.202400073","DOIUrl":"10.1002/bies.202400073","url":null,"abstract":"Sterols and the reductant nicotinamide adenine dinucleotide phosphate (NADPH), essential for eukaryotic life, arose because of, and as an adaptation to, rising levels of molecular oxygen (O2). Hence, the NADPH and O2-intensive process of sterol biosynthesis is inextricably linked to redox status. In mammals, cholesterol biosynthesis is exquisitely regulated post-translationally by multiple E3 ubiquitin ligases, with membrane associated Really Interesting New Gene (RING) C3HC4 finger 6 (MARCHF6) degrading at least six enzymes in the pathway. Intriguingly, all these MARCHF6-dependent enzymes require NADPH. Moreover, MARCHF6 is activated by NADPH, although what this means for control of cholesterol synthesis is unclear. Indeed, this presents a paradox for how NADPH regulates this vital pathway, since NADPH is a cofactor in cholesterol biosynthesis and yet, low levels of NADPH should spare cholesterol biosynthesis enzymes targeted by MARCHF6 by reducing its activity. We speculate MARCHF6 helps mammalian cells adapt to oxidative stress (signified by low NADPH levels) by reducing degradation of cholesterogenic enzymes, thereby maintaining synthesis of protective cholesterol.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From genetic mosaicism to tumorigenesis through indirect genetic effects 通过间接遗传效应，从基因嵌合到肿瘤发生。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-05-12 DOI: 10.1002/bies.202300238

Jean-Pascal Capp, Francesco Catania, Frédéric Thomas

{"title":"From genetic mosaicism to tumorigenesis through indirect genetic effects","authors":"Jean-Pascal Capp, Francesco Catania, Frédéric Thomas","doi":"10.1002/bies.202300238","DOIUrl":"10.1002/bies.202300238","url":null,"abstract":"Genetic mosaicism has long been linked to aging, and several hypotheses have been proposed to explain the potential connections between mosaicism and susceptibility to cancer. It has been proposed that mosaicism may disrupt tissue homeostasis by affecting intercellular communications and releasing microenvironmental constraints within tissues. The underlying mechanisms driving these tissue-level influences remain unidentified, however. Here, we present an evolutionary perspective on the interplay between mosaicism and cancer, suggesting that the tissue-level impacts of genetic mosaicism can be attributed to Indirect Genetic Effects (IGEs). IGEs can increase the level of cellular stochasticity and phenotypic instability among adjacent cells, thereby elevating the risk of cancer development within the tissue. Moreover, as cells experience phenotypic changes in response to challenging microenvironmental conditions, these changes can initiate a cascade of nongenetic alterations, referred to as Indirect non-Genetic Effects (InGEs), which in turn catalyze IGEs among surrounding cells. We argue that incorporating both InGEs and IGEs into our understanding of the process of oncogenic transformation could trigger a major paradigm shift in cancer research with far-reaching implications for practical applications.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202300238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0