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Compartmentalized signaling in the soma: Coordination of electrical and protein kinase A signaling at neuronal ER-plasma membrane junctions 体节中的区隔化信号传导：神经元ER-质膜连接处的电信号和蛋白激酶A信号的协调
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-13 DOI: 10.1002/bies.202400126
Nicholas C. Vierra
{"title":"Compartmentalized signaling in the soma: Coordination of electrical and protein kinase A signaling at neuronal ER-plasma membrane junctions","authors":"Nicholas C. Vierra","doi":"10.1002/bies.202400126","DOIUrl":"10.1002/bies.202400126","url":null,"abstract":"<p>Neuronal information processing depends on converting membrane depolarizations into compartmentalized biochemical signals that can modify neuronal activity and structure. However, our understanding of how neurons translate electrical signals into specific biochemical responses remains limited, especially in the soma where gene expression and ion channel function are crucial for neuronal activity. Here, I emphasize the importance of physically compartmentalizing action potential-triggered biochemical reactions within the soma. Emerging evidence suggests that somatic endoplasmic reticulum–plasma membrane (ER-PM) junctions are specialized organelles that coordinate electrical and biochemical signaling. The juxtaposition of ion channels and signaling proteins at a prominent subset of these sites enables compartmentalized calcium and cAMP-dependent protein kinase (PKA) signaling. I explore the hypothesis that these PKA-containing ER-PM junctions serve as critical sites for translating membrane depolarizations into PKA signals and identify key gaps in knowledge of the assembly, regulation, and neurobiological functions of this somatic signaling system.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health-promoting worms? Prospects and pitfalls of helminth therapy 促进健康的蠕虫？蠕虫疗法的前景与陷阱
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-12 DOI: 10.1002/bies.202400080
Ingrid Lamminpää, Federico Boem, Amedeo Amedei
{"title":"Health-promoting worms? Prospects and pitfalls of helminth therapy","authors":"Ingrid Lamminpää,&nbsp;Federico Boem,&nbsp;Amedeo Amedei","doi":"10.1002/bies.202400080","DOIUrl":"10.1002/bies.202400080","url":null,"abstract":"<p>In this manuscript, we explore the potential therapeutic use of helminths. After analyzing helminths’ role in connection with human health from the perspective of their symbiotic and evolutionary relationship, we critically examine some studies on their therapeutic applications. In doing so, we focus on some prominent mechanisms of action and potential benefits, but also on the exaggerations and theoretical and methodological difficulties of such proposals. We conclude that further studies are needed to fully explore the potential benefits of this perspective, and we encourage the scientific community in doing so.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The researcher's guide to selecting biomarkers in mental health studies 研究人员在心理健康研究中选择生物标记物指南
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-11 DOI: 10.1002/bies.202300246
Josine E. Verhoeven, Owen M. Wolkowitz, Isaac Barr Satz, Quinn Conklin, Femke Lamers, Catharina Lavebratt, Jue Lin, Daniel Lindqvist, Stefanie E. Mayer, Philippe A. Melas, Yuri Milaneschi, Martin Picard, Ryan Rampersaud, Natalie Rasgon, Kathryn Ridout, Gustav Söderberg Veibäck, Caroline Trumpff, Audrey R. Tyrka, Kathleen Watson, Gwyneth Winnie Y. Wu, Ruoting Yang, Anthony S. Zannas, Laura K. M. Han, Kristoffer N. T. Månsson
{"title":"The researcher's guide to selecting biomarkers in mental health studies","authors":"Josine E. Verhoeven,&nbsp;Owen M. Wolkowitz,&nbsp;Isaac Barr Satz,&nbsp;Quinn Conklin,&nbsp;Femke Lamers,&nbsp;Catharina Lavebratt,&nbsp;Jue Lin,&nbsp;Daniel Lindqvist,&nbsp;Stefanie E. Mayer,&nbsp;Philippe A. Melas,&nbsp;Yuri Milaneschi,&nbsp;Martin Picard,&nbsp;Ryan Rampersaud,&nbsp;Natalie Rasgon,&nbsp;Kathryn Ridout,&nbsp;Gustav Söderberg Veibäck,&nbsp;Caroline Trumpff,&nbsp;Audrey R. Tyrka,&nbsp;Kathleen Watson,&nbsp;Gwyneth Winnie Y. Wu,&nbsp;Ruoting Yang,&nbsp;Anthony S. Zannas,&nbsp;Laura K. M. Han,&nbsp;Kristoffer N. T. Månsson","doi":"10.1002/bies.202300246","DOIUrl":"10.1002/bies.202300246","url":null,"abstract":"<p>Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 10","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202300246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue-resident memory T cells: Harnessing their properties against infection for cancer treatment 组织驻留记忆 T 细胞：利用其抗感染特性治疗癌症
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-11 DOI: 10.1002/bies.202400119
João Fernandes, Marc Veldhoen, Cristina Ferreira
{"title":"Tissue-resident memory T cells: Harnessing their properties against infection for cancer treatment","authors":"João Fernandes,&nbsp;Marc Veldhoen,&nbsp;Cristina Ferreira","doi":"10.1002/bies.202400119","DOIUrl":"10.1002/bies.202400119","url":null,"abstract":"<p>We have rapidly gained insights into the presence and function of T lymphocytes in non-lymphoid tissues, the tissue-resident memory T (T<sub>RM</sub>) cells. The central pillar of adaptive immunity has been expanded from classic central memory T cells giving rise to progeny upon reinfection and effector memory cells circulating through the blood and patrolling the tissues to include T<sub>RM</sub> cells that reside and migrate inside solid organs and tissues. Their development and maintenance have been studied in detail, providing exciting clues on how their unique properties used to fight infections may benefit therapies against solid tumors. We provide an overview of CD8 T<sub>RM</sub> cells and the properties that make them of interest for vaccination and cancer therapies.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond RNAi: How the Dicer protein modulates the antiviral innate immune response in mammalian cells 超越 RNAi：Dicer 蛋白如何调节哺乳动物细胞的抗病毒先天免疫反应：哺乳动物的 Dicer 由于失去了长 dsRNA 的加工活性，因此可以不依赖 RNAi 的方式调节先天性免疫反应。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-09 DOI: 10.1002/bies.202400173
Léa Gaucherand, Morgane Baldaccini, Sébastien Pfeffer
{"title":"Beyond RNAi: How the Dicer protein modulates the antiviral innate immune response in mammalian cells","authors":"Léa Gaucherand,&nbsp;Morgane Baldaccini,&nbsp;Sébastien Pfeffer","doi":"10.1002/bies.202400173","DOIUrl":"10.1002/bies.202400173","url":null,"abstract":"<p>While Dicer plays an important antiviral role through the RNAi pathway in plants and invertebrates, its contribution to antiviral immunity in vertebrates and more specifically mammals is more controversial. The apparent limited RNAi activity in mammalian cells has been attributed to the reduced long dsRNA processive activity of mammalian Dicer, as well as a functional incompatibility between the RNAi and IFN pathways. Why Dicer has lost this antiviral activity in the profit of the IFN pathway is still unclear. We propose that the primary direct antiviral activity of Dicer has been functionally replaced by other sensors in the IFN pathway, leading to its specialization toward microRNA maturation. As a result, Dicer can regulate the innate immune response and prevent basal activation of the IFN pathway in mammals. Here, we discuss this hypothesis, highlighting how the adaptation of the helicase domain of mammalian Dicer may be key to this process.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on plant stress-associated protein (SAP) family: Master regulators to deal with environmental stresses 植物胁迫相关蛋白（SAP）家族的研究进展：应对环境胁迫的主调节因子
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-09 DOI: 10.1002/bies.202400097
Rania Ben Saad, Walid Ben Romdhane, Natália Čmiková, Narjes Baazaoui, Mohamed Taieb Bouteraa, Bouthaina Ben Akacha, Yosra Chouaibi, Maria Maisto, Anis Ben Hsouna, Stefania Garzoli, Alina Wiszniewska, Miroslava Kačániová
{"title":"Research progress on plant stress-associated protein (SAP) family: Master regulators to deal with environmental stresses","authors":"Rania Ben Saad,&nbsp;Walid Ben Romdhane,&nbsp;Natália Čmiková,&nbsp;Narjes Baazaoui,&nbsp;Mohamed Taieb Bouteraa,&nbsp;Bouthaina Ben Akacha,&nbsp;Yosra Chouaibi,&nbsp;Maria Maisto,&nbsp;Anis Ben Hsouna,&nbsp;Stefania Garzoli,&nbsp;Alina Wiszniewska,&nbsp;Miroslava Kačániová","doi":"10.1002/bies.202400097","DOIUrl":"10.1002/bies.202400097","url":null,"abstract":"<p>Every year, unfavorable environmental factors significantly affect crop productivity and threaten food security. Plants are sessile; they cannot move to escape unfavorable environmental conditions, and therefore, they activate a variety of defense pathways. Among them are processes regulated by stress-associated proteins (SAPs). SAPs have a specific zinc finger domain (A20) at the N-terminus and either AN1 or C2H2 at the C-terminus. SAP proteins are involved in many biological processes and in response to various abiotic or biotic constraints. Most SAPs play a role in conferring transgenic stress resistance and are stress-inducible. The emerging field of SAPs in abiotic or biotic stress response regulation has attracted the attention of researchers. Although SAPs interact with various proteins to perform their functions, the exact mechanisms of these interactions remain incompletely understood. This review aims to provide a comprehensive understanding of SAPs, covering their diversity, structure, expression, and subcellular localization. SAPs play a pivotal role in enabling crosstalk between abiotic and biotic stress signaling pathways, making them essential for developing stress-tolerant crops without yield penalties. Collectively, understanding the complex regulation of SAPs in stress responses can contribute to enhancing tolerance against various environmental stresses through several techniques such as transgenesis, classical breeding, or gene editing.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis 危险的联系黑色素瘤形成过程中角质细胞失去对黑色素细胞的控制。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-04 DOI: 10.1002/bies.202400135
Kathleen J. Green, Jenny Pokorny, Brieanna Jarrell
{"title":"Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis","authors":"Kathleen J. Green,&nbsp;Jenny Pokorny,&nbsp;Brieanna Jarrell","doi":"10.1002/bies.202400135","DOIUrl":"10.1002/bies.202400135","url":null,"abstract":"<p>Melanomas arise from transformed melanocytes, positioned at the dermal-epidermal junction in the basal layer of the epidermis. Melanocytes are completely surrounded by keratinocyte neighbors, with which they communicate through direct contact and paracrine signaling to maintain normal growth control and homeostasis. UV radiation from sunlight reshapes this communication network to drive a protective tanning response. However, repeated rounds of sun exposure result in accumulation of mutations in melanocytes that have been considered as primary drivers of melanoma initiation and progression. It is now clear that mutations in melanocytes are not sufficient to drive tumor formation—the tumor environment plays a critical role. This review focuses on changes in melanocyte-keratinocyte communication that contribute to melanoma initiation and progression, with a particular focus on recent mechanistic insights that lay a foundation for developing new ways to intercept melanoma development.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A unified theoretical framework underlying the regulation of motivated behavior 动机行为调节的统一理论框架。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-09-02 DOI: 10.1002/bies.202400016
Yu-Been Kim, Young Hee Lee, Shee-June Park, Hyung Jin Choi
{"title":"A unified theoretical framework underlying the regulation of motivated behavior","authors":"Yu-Been Kim,&nbsp;Young Hee Lee,&nbsp;Shee-June Park,&nbsp;Hyung Jin Choi","doi":"10.1002/bies.202400016","DOIUrl":"10.1002/bies.202400016","url":null,"abstract":"<p>To orchestrate behaviors for survival, multiple psychological components have evolved. The current theories do not clearly distinguish the distinct components. In this article, we provide a unified theoretical framework. To optimize survival, there should be four components; (1) “need”, an alarm based on a predicted deficiency. (2) “motivation”, a direct behavior driver. (3) “pleasure”, a teacher based on immediate outcomes. (4) “utility”, a teacher based on final delayed outcomes. For behavior stability, need should be accumulated into motivation to drive behavior. Based on the immediate outcome of the behavior, the pleasure should teach whether to continue the current behavior. Based on the final delay outcome, the utility should teach whether to increase future behavior by reshaping the other three components. We provide several neural substrate candidates in the food context. The proposed theoretical framework, in combination with appropriate experiments, will unravel the neural components responsible for each theoretical component.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: BioEssays 9/2024 发行信息：生物论文 9/2024
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-08-30 DOI: 10.1002/bies.202470014
{"title":"Issue Information: BioEssays 9/2024","authors":"","doi":"10.1002/bies.202470014","DOIUrl":"https://doi.org/10.1002/bies.202470014","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 9","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202470014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ubiquitin-mediated endosomal stress: A novel organelle stress of early endosomes that initiates cellular signaling pathways 泛素介导的内体压力：启动细胞信号通路的早期内体的一种新型细胞器应激：USP8 是泛素介导的内体压力的看门人，可抵消细胞信号通路的激活。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-08-28 DOI: 10.1002/bies.202400127
Akinori Endo, Masayuki Komada, Yukiko Yoshida
{"title":"Ubiquitin-mediated endosomal stress: A novel organelle stress of early endosomes that initiates cellular signaling pathways","authors":"Akinori Endo,&nbsp;Masayuki Komada,&nbsp;Yukiko Yoshida","doi":"10.1002/bies.202400127","DOIUrl":"10.1002/bies.202400127","url":null,"abstract":"<p>Cells utilize diverse organelles to maintain homeostasis and to respond to extracellular stimuli. Recently, multifaceted aspects of organelle stress caused by various factors have been emerging. The endosome is an essential organelle, functioning as the central hub for membrane trafficking in cooperation with the ubiquitin system. However, knowledge regarding endosomal stress, which refers to organelle stress of the endosome, is currently limited. We recently revealed ubiquitin-mediated endosomal stress of early endosomes (EEs) and its responsive signaling pathways. These findings shed light on the relevance of ubiquitin-mediated endosomal stress to physiological and pathological processes. Here, we present a hypothesis that ubiquitin-mediated endosomal stress may have significant roles in biological contexts and that ubiquitin-specific protease 8 is a key regulator of ubiquitin clearance from EEs.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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