{"title":"G蛋白偶联受体信号在初级纤毛的交叉。","authors":"Christina E. Wang, Stacey K. Ogden","doi":"10.1002/bies.70015","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Primary cilia are singular projections that extend from the surface of most vertebrate cell types. The surface area of the primary cilium (PC) is estimated to represent only 1/100<sup>th</sup> of the total membrane surface of an average cell. Despite this, the PC provides essential contributions to inter- and intracellular communication by housing receptors and downstream effectors for myriad cell-signaling cascades. G protein-coupled receptors (GPCRs) commonly enrich along ciliary membranes to control a diverse range of cellular behaviors by signaling through a shared pool of downstream effectors. This suggests the hypothesis that the PC provides an environment that is conducive to complementary or competitive GPCR Signal Crosstalk. In this Hypothesis Bio Essay, we use the Sonic Hedgehog (SHH) pathway as a case study to inform models of how GPCR signals could intersect in primary cilia and suggest general strategies to test each model.</p>\n </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 7","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"G Protein-Coupled Receptor Signal Intersection at the Primary Cilium\",\"authors\":\"Christina E. Wang, Stacey K. Ogden\",\"doi\":\"10.1002/bies.70015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Primary cilia are singular projections that extend from the surface of most vertebrate cell types. The surface area of the primary cilium (PC) is estimated to represent only 1/100<sup>th</sup> of the total membrane surface of an average cell. Despite this, the PC provides essential contributions to inter- and intracellular communication by housing receptors and downstream effectors for myriad cell-signaling cascades. G protein-coupled receptors (GPCRs) commonly enrich along ciliary membranes to control a diverse range of cellular behaviors by signaling through a shared pool of downstream effectors. This suggests the hypothesis that the PC provides an environment that is conducive to complementary or competitive GPCR Signal Crosstalk. In this Hypothesis Bio Essay, we use the Sonic Hedgehog (SHH) pathway as a case study to inform models of how GPCR signals could intersect in primary cilia and suggest general strategies to test each model.</p>\\n </div>\",\"PeriodicalId\":9264,\"journal\":{\"name\":\"BioEssays\",\"volume\":\"47 7\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioEssays\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bies.70015\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioEssays","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bies.70015","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
G Protein-Coupled Receptor Signal Intersection at the Primary Cilium
Primary cilia are singular projections that extend from the surface of most vertebrate cell types. The surface area of the primary cilium (PC) is estimated to represent only 1/100th of the total membrane surface of an average cell. Despite this, the PC provides essential contributions to inter- and intracellular communication by housing receptors and downstream effectors for myriad cell-signaling cascades. G protein-coupled receptors (GPCRs) commonly enrich along ciliary membranes to control a diverse range of cellular behaviors by signaling through a shared pool of downstream effectors. This suggests the hypothesis that the PC provides an environment that is conducive to complementary or competitive GPCR Signal Crosstalk. In this Hypothesis Bio Essay, we use the Sonic Hedgehog (SHH) pathway as a case study to inform models of how GPCR signals could intersect in primary cilia and suggest general strategies to test each model.
期刊介绍:
molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged
BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.