Fusion Pores as Regulators of Quantal Size and Cellular Physiology.

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-09-07 DOI:10.1002/bies.70064
Bhavya R Bhaskar, Shahina Mazumdar, Sruthilaya Dayanandan, Debasis Das
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引用次数: 0

Abstract

The timely release of chemical messengers is a crucial step in cell-to-cell communication. Does this release occur as a passive diffusion from the donor membrane or it is actively regulated? A series of studies indicated that chemical messengers' secretion is "sub-quantal". This mode of secretion demands a strongly regulated release mechanism and calls for a thorough characterization of the release sites. When secretory vesicles fuse with the plasma membrane, ephemeral fusion pores serve as the first aqueous connection between the lumen of secretory vesicle and the cell exterior through which chemical messengers are released. Here, we discuss the molecular players that directly regulate fusion pore properties. This has consequences in controlling the amount of chemical messengers' secretion, hence controlling the quantal size. A thorough understanding of the role of regulatory factors in controlling quantal size can help design potent therapeutics to alter vesicular secretion under pathological conditions.

融合孔作为量子大小和细胞生理的调节因子。
及时释放化学信使是细胞间通讯的关键一步。这种释放是作为供体膜的被动扩散还是受到主动调节?一系列研究表明,化学信使的分泌是“亚量子”的。这种分泌模式需要一个强烈调节的释放机制,并要求对释放部位进行彻底的表征。当分泌囊泡与质膜融合时,短暂的融合孔作为分泌囊泡管腔与细胞外部的第一个水通道,化学信使通过该通道被释放。在这里,我们讨论了直接调节融合孔性质的分子参与者。这就控制了化学信使的分泌量,从而控制了量子大小。彻底了解调控因子在控制量大小中的作用可以帮助设计有效的治疗方法来改变病理条件下的水疱分泌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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