{"title":"BioEssays 9/2025","authors":"","doi":"10.1002/bies.70053","DOIUrl":null,"url":null,"abstract":"<p>In article 70044 Lana Kostic and Nick Barker review the evolving understanding of stem cell dynamics in the esophagus, with a focus on their roles in tissue homeostasis and cancer development. Challenging earlier models that proposed a uniform basal progenitor layer, recent findings suggest a heterogeneous pool of stem and progenitor cells with distinct phenotypic and functional traits. This cellular diversity may influence individual susceptibility to esophageal cancer, which can arise from random mutations or cancer stem cell activity. The authors highlight how advances in single-cell technologies and organoid models are reshaping perspectives on esophageal biology and offer promising avenues for therapeutic innovation. By re-evaluating stem cell identity and behavior, the article underscores the complexity of epithelial maintenance and the multifactorial nature of cancer initiation in the esophagus.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70053","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioEssays","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bies.70053","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
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Abstract
In article 70044 Lana Kostic and Nick Barker review the evolving understanding of stem cell dynamics in the esophagus, with a focus on their roles in tissue homeostasis and cancer development. Challenging earlier models that proposed a uniform basal progenitor layer, recent findings suggest a heterogeneous pool of stem and progenitor cells with distinct phenotypic and functional traits. This cellular diversity may influence individual susceptibility to esophageal cancer, which can arise from random mutations or cancer stem cell activity. The authors highlight how advances in single-cell technologies and organoid models are reshaping perspectives on esophageal biology and offer promising avenues for therapeutic innovation. By re-evaluating stem cell identity and behavior, the article underscores the complexity of epithelial maintenance and the multifactorial nature of cancer initiation in the esophagus.
期刊介绍：
molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged
BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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