Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation: A critical analysis of "Active control of mitochondrial network morphology by metabolism-driven redox state" by Singh et al. and studies replacing ETC components with yeast counterparts.
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引用次数: 0
Abstract
Recently, a fascinating, well-executed, molecular study regarding the direct influence of mitochondrial reactive oxygen species (ROS) formation by the electron transport chain (ETC) on mitochondrial morphology in baker's yeast appeared in PNAS. The findings highlight some very interesting connections between the choice of metabolic substrates, points of entry into the ETC, ROS formation, efficiency of ATP generation, and mitochondrial structures. These reflect both ancient eukaryotic constraints and later specific adaptations of Saccharomyces cerevisiae. However, by not addressing these adaptations, the important wider implications of the article's findings run the risk of being overlooked. There are illuminating connections to the FADH2/NADH ratio concept and new studies replacing ETC components with yeast counterparts in diverse metazoan cells, which will also be discussed.
期刊介绍：
molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged
BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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