表观遗传学告诉我们神经元与胶质瘤的相互作用。

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-07-20 DOI:10.1002/bies.70043
Chaitali Chakraborty, Itzel Nissen, Silvia Remeseiro
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引用次数: 0

摘要

神经元与胶质瘤的相互作用是胶质瘤进展的关键驱动因素,神经元活动通过旁分泌信号和直接突触输入促进肿瘤生长和侵袭。除了公认的谷氨酸能突触外,最近的发现表明gaba能相互作用也有助于胶质瘤的增殖。在这里,我们关注胶质瘤细胞如何通过表观遗传机制解码神经元信号,包括增强子重编程、染色质重塑和3D基因组组织的重新布线,以及转录因子如SMAD3和PITX1协调转录程序,维持神经元到胶质瘤的通讯。此外,最近整合的多组学数据强调了与gaba能信号相关的基因调控网络在胶质母细胞瘤(GB)发病机制中的作用。我们还强调了gaba能信号在胶质瘤亚型中的独特作用,并指出,在GB中,gaba相关的代谢和旁分泌机制,而不是突触输入,可能驱动肿瘤进展。了解表观遗传重编程如何促进胶质瘤整合到神经回路中,为通过靶向表观遗传机制破坏这些恶性神经元-胶质瘤相互作用开辟了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

What Epigenetics Teaches Us About Neuron–Glioma Interactions

What Epigenetics Teaches Us About Neuron–Glioma Interactions

Neuron–glioma interactions are critical drivers of glioma progression, with neuronal activity promoting tumor growth and invasion through paracrine signaling and direct synaptic input. Beyond well-established glutamatergic synapses, recent discoveries revealed that GABAergic interactions also contribute to glioma proliferation. Here, we focus on how glioma cells decode neuronal cues via epigenetic mechanisms, including enhancer reprogramming, chromatin remodeling, and rewiring of 3D genome organization, with transcriptions factors such as SMAD3 and PITX1 orchestrating transcriptional programs that sustain neuron-to-glioma communication. Additionally, recent integration of multi-omics data highlights gene regulatory networks linked to GABAergic signaling as contributors to glioblastoma (GB) pathogenesis. We also underscore the distinct roles of GABAergic signaling across glioma subtypes, noting that, in GB, GABA-related metabolic and paracrine mechanisms, rather than synaptic input, may drive tumor progression. Understanding how epigenetic reprogramming facilitates glioma integration into neural circuits opens new avenues to disrupt these malignant neuron–glioma interactions by targeting the epigenetic machinery.

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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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