Aβ的变色龙性质:对阿尔茨海默病和其他淀粉样疾病的影响。

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-07-11 DOI:10.1002/bies.70039
Birgit Strodel
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引用次数: 0

摘要

淀粉样蛋白β肽(Aβ)与阿尔茨海默病有关,表现出显著的多态性。在单体水平上,受环境条件的影响,Aβ可以采用无序、螺旋和β-发夹结构。低聚和纤维状状态,以β-片的普遍存在为特征,在β-链的排列上都是多态的。这种变色龙般的行为源于Aβ的独特序列和相对平坦的能量格局,这有利于聚集,可能有助于阿尔茨海默病的流行,同时也使分解,从而减缓疾病进展。相比之下,更为罕见的克雅氏病的发展速度要快得多,这可能是由于朊蛋白的能量格局更陡峭。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases

Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases

The amyloid-β peptide (Aβ), implicated in Alzheimer's disease, exhibits significant polymorphism. At the monomer level, Aβ can adopt disordered, helical, and β-hairpin structures, influenced by environmental conditions. Both oligomeric and fibrillar states, characterized by the prevalence of β-sheets, are polymorphic in the arrangement of β-strands. This chameleon-like behavior arises from Aβ’s unique sequence and relatively flat energy landscape, which facilitates aggregation and may contribute to the prevalence of Alzheimer's disease, while also enabling disaggregation, thus slowing disease progression. In contrast, Creutzfeldt-Jakob disease, which is much rarer, progresses far more rapidly, likely due to the steeper energy landscape of the prion protein.

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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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