Glymphatic Transport as a Possible New Mechanism for the Long-Range Signaling of Extracellular Vesicles Through the CNS

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-07-15 DOI:10.1002/bies.70040
Agnė Pociūtė, Augustas Pivoriūnas
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引用次数: 0

Abstract

Extracellular vesicles (EVs) are secreted by all types of cells in the central nervous system (CNS) and participate in intercellular communication in physiological and pathological settings. However, an emerging view of multidirectional communications is getting incredibly complex, and, in most cases, it is unclear whether EVs secreted by specific cell populations have specific cellular targets. Here we propose to discriminate between short- (adjacent cells) and long- (different brain regions) range signaling of the EVs in the CNS. We also hypothesize that besides its primary function of brain clearance, the glymphatic system can also serve for the long-range transport and signaling of the EVs throughout the CNS. In the first part of the review, we will describe currently available experimental models used for labeling and tracking cell-type specific EVs in the CNS. Then we will briefly overview the glymphatic system and discuss current evidence showing the physiological and pathological significance of long-range EV signaling in the CNS. Finally, we will provide a hypothetical model describing the possible role of the glymphatic system in the transport and long-range signaling of the EVs.

Abstract Image

淋巴转运作为细胞外囊泡通过中枢神经系统远距离信号传导的可能新机制。
细胞外囊泡(EVs)由中枢神经系统(CNS)中所有类型的细胞分泌,并参与生理和病理环境下的细胞间通讯。然而,一种新兴的多向通信观点正变得异常复杂,而且在大多数情况下,尚不清楚特定细胞群分泌的ev是否具有特定的细胞靶标。在这里,我们建议区分短(相邻细胞)和长(不同脑区)范围的中枢神经系统的ev信号。我们还假设,除了脑清除的主要功能外,淋巴系统还可以在整个中枢神经系统中参与ev的远程运输和信号传递。在回顾的第一部分,我们将描述目前可用的实验模型,用于标记和跟踪中枢神经系统中特定细胞类型的ev。然后,我们将简要概述淋巴系统,并讨论目前的证据表明,远距离EV信号在中枢神经系统中的生理和病理意义。最后,我们将提供一个假设模型来描述类淋巴系统在电动汽车的运输和远程信号传递中的可能作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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