British Journal of Nutrition最新文献_第6页

Effects of phytosterol-enriched corn-wheat germ blended oil on immune markers and T-cell subsets in Chinese adults with dyslipidaemia: a secondary analysis of a randomised controlled trial - CORRIGENDUM. 富含植物甾醇的玉米-小麦胚芽混合油对中国成人血脂异常患者免疫标记物和t细胞亚群的影响：一项随机对照试验的二次分析-勘误

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-09-09 DOI: 10.1017/S0007114526108393

Sikai Dong, Jiayue Xia, Zhiwen Zhang, Tianyu Wu, Rui Zhang, Zhi He, Guo-Fang Shu, Zhiyuan Feng, Junhui Yu, Jiongnan Wang, Shiyu Yin, Ligang Yang, Wang Liao, Hui Xia, Shaokang Wang, Da Pan, Guiju Sun

引用次数: 0

Eating-timing patterns derived from K-means clustering and mortality risk in US adults with chronic diseases: a cohort study. 美国成人慢性疾病患者的k -均值聚类饮食时间模式与死亡风险：一项队列研究

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-09-08 DOI: 10.1017/S0007114526108332

Renjie Huang, Miao Huang, Rui Zhang

{"title":"Eating-timing patterns derived from K-means clustering and mortality risk in US adults with chronic diseases: a cohort study.","authors":"Renjie Huang, Miao Huang, Rui Zhang","doi":"10.1017/S0007114526108332","DOIUrl":"https://doi.org/10.1017/S0007114526108332","url":null,"abstract":"Whether joint eating-timing configurations show comparable mortality associations across chronic diseases is uncertain. We analysed 26 712 adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 who had two reliable 24-h dietary recalls and mortality linkage. Participant-level mean first eating time and eating-window duration were standardised and classified by K-means. Survey-weighted Cox models incorporated strata and primary sampling units within six chronic disease domains; missing covariates were multiply imputed in thirty datasets and prespecified Benjamini-Hochberg false-discovery-rate families addressed multiplicity. Three patterns represented 30·2 % (early-start), 57·2 % (intermediate) and 12·6 % (late-start) of the weighted population. During 224 837·9 person-years, 3279 deaths occurred. None of the six all-cause mortality global tests met the prespecified false-discovery-rate threshold (all q ≥ 0·281). In the cancer domain, the late-start pattern yielded a higher estimated hazard of cancer mortality than early-start (hazard ratio 1·88, 95 % CI 1·15-3·06; P = 0·012), but the global q was 0·052 and pairwise q was 0·073. This association attenuated after exclusion of early deaths and was not reproduced in an independent Day 1 analysis. Proportional hazards were not supported in three models, for which estimates weakened or crossed the null over follow-up. Eating-timing patterns were not universal mortality predictors across chronic diseases. Their nutritional relevance appears context-dependent, and repeated timing assessments with clinical measures of disease severity are needed before these patterns can inform personalised nutritional care.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.1,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dairy and plant-based beverages purchased by Canadian households between 2018 and 2020. 2018年至2020年加拿大家庭购买的乳制品和植物性饮料。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-10 DOI: 10.1017/S0007114526108149

Virginie Drolet-Labelle, Jennifer J Lee, Véronique Provencher, Lana Vanderlee

{"title":"Dairy and plant-based beverages purchased by Canadian households between 2018 and 2020.","authors":"Virginie Drolet-Labelle, Jennifer J Lee, Véronique Provencher, Lana Vanderlee","doi":"10.1017/S0007114526108149","DOIUrl":"10.1017/S0007114526108149","url":null,"abstract":"Canada's food guide (CFG), updated in 2019, recommends choosing lower-fat milk, fortified plant-based milk alternatives and unsweetened beverages. This study examined trends in household purchases of dairy beverages and plant-based beverages (PBB), following CFG release, as well as price differences between beverage categories. NielsenIQ HomeScan data from 2018 to 2020 (about 4500 households/year) in Québec and Ontario were analysed for annual purchases of total dairy beverages (milk, drinkable yogurt/kefir and milkshakes) and total PBB (milk alternatives and plant-based drinkable yogurt/kefir). Product descriptions/Universal Product Codes (n 1451) were matched to online nutrition information. Mixed linear models examined changes in volume purchased over time, adjusting for household sociodemographic characteristics, and linear regressions examined price differences. On average, households purchased 97·0 litres of total dairy beverages and 8·8 litres of total PBB annually, with 2 % milk (45·7 L) and almond beverages (4·9 L) being the most purchased in these categories. Purchases of total dairy beverages, dairy beverages with added sugars, skim, 1 % and 2 % milk were lower in 2019 than in 2018. However, purchases were higher in 2020 than in 2019 for total dairy beverages, 2 % and whole milk, total PBB, almond beverages and 'other' types of milk alternatives. Soya beverage purchases remained unchanged. Households with children purchased more dairy products with added sugars and whole milk and fewer PBB. Differences by province, education and ethnicity were also found. No differences in price per 100ml were observed between PBB and dairy beverages purchased ($0·23CAD/100 ml v. $0·22CAD/100 ml, p = 0·288), and dairy beverages purchased were more expensive in Québec than Ontario. Overall, results suggest partial alignment with 2019 CFG recommendations.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectrical impedance analysis v. dual-energy X-ray absorptiometry for assessing segmental body composition in healthy adults - ERRATUM. 生物电阻抗分析。评估健康成人节段体组成的双能x射线吸收测定法。勘误

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-10 DOI: 10.1017/S000711452610823X

Mohammadreza Aliakbari, Afrah Almusawy, Yahya Jalilpiran, Fatemeh Afzalzadeh-Naeini, Hanieh Lorzadeh Amin, Seyede Motahare Amiri, Salih Zebari, Kurosh Djafarian

引用次数: 0

Proteome-wide interaction study of fatty acids and mortality in the UK Biobank. 脂肪酸与英国生物银行死亡率的蛋白质组相互作用研究。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-10 DOI: 10.1017/S0007114526108204

Ziyan Qiao, Xinru Wang, Chengzhe Tao, Sijing Liao, Jiawei Lu, Yiting Yuan, Qiaoqiao Xu, Yun Fan, Xu Wang, Chuncheng Lu

{"title":"Proteome-wide interaction study of fatty acids and mortality in the UK Biobank.","authors":"Ziyan Qiao, Xinru Wang, Chengzhe Tao, Sijing Liao, Jiawei Lu, Yiting Yuan, Qiaoqiao Xu, Yun Fan, Xu Wang, Chuncheng Lu","doi":"10.1017/S0007114526108204","DOIUrl":"https://doi.org/10.1017/S0007114526108204","url":null,"abstract":"The heterogeneity in associations between circulating fatty acids (FA) and mortality remained underexplored. Proteomics can profile the human physiological status. This study aimed to estimate interactions between FA and proteins in relation to mortality. We randomly divided 30,190 UK Biobank participants into train and test datasets. Multivariable Cox regression was utilized to assess the associations between FA and all-cause mortality and to explore proteome-wide interactions of FA in relation to mortality. Subgroup analyses were conducted to examine heterogeneity across varied protein levels. We also explored interactions between proteins and FA in relation to cause-specific mortality. We documented 3,345 deaths during 13.9 years of follow-up. MUFA-pct, Non-LA Omega-6 pct, Omega-6/Omega-3 ratio and SFA-pct were positively associated with all-cause mortality, while PUFA-pct, DHA-pct, LA-pct, and Omega-3-pct were negatively associated. We identified several robust interactions of proteins with MUFA-pct (n = 3), Omega-3-pct (n = 4), and Omega-6/Omega-3 ratio (n = 2). In subgroup analyses, individuals with high-level TNFRSF1B, MMP10, and CRHBP had higher all-cause mortality risks associated with MUFA-pct, while protective associations between Omega-3-pct and all-cause mortality were stronger among individuals with high-level TSPAN8, PLAU, ITGA5, and CEACAM1. Moreover, participants with high-level TSPAN8 and PLAU had higher risks of all-cause mortality with Omega-6/Omega-3 ratio. For cause-specific mortality, interaction and subgroup results were largely consistent with those of all-cause mortality. Our findings can provide new insights into heterogeneity in FA-mortality associations and highlight potential protein targets for personalized interventions across individuals with different physiological status.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-34"},"PeriodicalIF":3.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary patterns, metabolomics and incident gastroesophageal reflux disease: a prospective cohort study. 饮食模式、代谢组学和胃食管反流病的发生率：一项前瞻性队列研究。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-06 DOI: 10.1017/S0007114526108162

Lei Zhang, Chunhui Ma, Yu Chen, Hao Huang, Zhiping Long, Fulan Hu

{"title":"Dietary patterns, metabolomics and incident gastroesophageal reflux disease: a prospective cohort study.","authors":"Lei Zhang, Chunhui Ma, Yu Chen, Hao Huang, Zhiping Long, Fulan Hu","doi":"10.1017/S0007114526108162","DOIUrl":"10.1017/S0007114526108162","url":null,"abstract":"Prospective evidence linking overall diet quality to gastroesophageal reflux disease (GERD) is limited, and metabolic pathways remain unclear. In a cohort of 183 878 adults free of GERD at baseline, we examined nine dietary pattern scores derived from repeated 24-h dietary recalls and assessed associations with incident GERD over a median follow-up of 13·2 years, during which 15 401 cases occurred. Higher adherence to healthy patterns including Mediterranean diet, Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay, Dietary Approaches to Stop Hypertension and dietary index for gut microbiota was associated with lower GERD risk (highest v. lowest tertile hazard ratios 0·87-0·89), whereas a pro-inflammatory pattern (Energy-adjusted Diet Inflammatory Index) was linked to higher risk (hazard ratio 1·11). In a metabolomics sub-cohort (N 98 669), diet-related NMR metabolomic signatures, derived from 168 biomarkers using Elastic Net regression, reflected similar associations and mediated 11·1-32·2 % of the diet-GERD relationship. Associations were largely consistent across subgroups and robust in sensitivity analyses, supporting a potential role of systemic metabolic profiles in mediating the effects of diet on GERD and highlighting metabolic mechanisms underlying diet-related disease risk.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Sugar-Sweetened Beverage Consumption with Observed Sleep Apnea and Perceived Stress among Korean Adults Aged 40 Years and Older: Analysis of KNHANES 2019-2023. 韩国40岁及以上成年人中含糖饮料消费与观察到的睡眠呼吸暂停和感知压力的关系：KNHANES 2019-2023分析

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-06 DOI: 10.1017/S0007114526108228

Minseo Kim, Jihye Jung, Jane J Lee

{"title":"Association of Sugar-Sweetened Beverage Consumption with Observed Sleep Apnea and Perceived Stress among Korean Adults Aged 40 Years and Older: Analysis of KNHANES 2019-2023.","authors":"Minseo Kim, Jihye Jung, Jane J Lee","doi":"10.1017/S0007114526108228","DOIUrl":"https://doi.org/10.1017/S0007114526108228","url":null,"abstract":"Epidemiologic evidence on the association between sugar-sweetened beverage (SSB) consumption and sleep-related symptoms or perceived stress remains limited, especially among middle-aged and older adults. This study examined the associations between SSB consumption and observed sleep apnea, snoring, daytime tiredness, and perceived stress among Korean adults aged 40 years and older. Cross-sectional data from the Korea National Health and Nutrition Examination Survey 2019-2023 were analyzed (n = 17,255). SSB consumption was assessed via 24-hour dietary recall and categorized as non-consumers, moderate consumers (Q1-Q3), and high consumers (Q4). Multivariable logistic regression with complex survey design adjustment was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Among 17,255 participants (mean age 60.2 years, 57.5% women), 10,169 (58.9%) were SSB consumers. Compared with non-consumers (n = 7,086), the highest intake group (Q4, n = 2,542) showed higher odds of observed sleep apnea (OR 1.32; 95% CI 1.09-1.60) and perceived stress (OR 1.23; 95% CI 1.08-1.40). In sex-stratified analyses, the association with observed sleep apnea was significant among men (OR 1.29; 95% CI 1.04-1.60) but not women (OR 1.22; 95% CI 0.89-1.67), although formal interaction analyses did not support significant effect modification by sex. Higher odds of perceived stress were observed in both men (OR 1.24; 95% CI 1.02-1.50) and women (OR 1.22; 95% CI 1.02-1.45). No significant associations were found for snoring or daytime tiredness. Higher SSB consumption was associated with observed sleep apnea and perceived stress, and prospective studies are needed to clarify temporal relationships and underlying mechanisms.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-23"},"PeriodicalIF":3.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies. 坚果摄入与高血压风险：前瞻性研究的系统回顾和剂量反应荟萃分析。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-04 DOI: 10.1017/S0007114526108137

Michael Metoudi, Isabelle Sadler, Shireen Kassam, Dagfinn Aune

{"title":"Nut consumption and the risk of hypertension: a systematic review and dose response meta-analysis of prospective studies.","authors":"Michael Metoudi, Isabelle Sadler, Shireen Kassam, Dagfinn Aune","doi":"10.1017/S0007114526108137","DOIUrl":"https://doi.org/10.1017/S0007114526108137","url":null,"abstract":"Previous studies have suggested that a high intake of nuts may reduce the risk of hypertension, however, the available data have been limited. Several additional studies have recently been published on the topic. We therefore conducted a systematic review and meta-analysis of cohort studies on nut consumption and hypertension to provide an updated assessment of the evidence. PubMed and Embase databases were searched up to 4th April 2026 for prospective cohort studies with adjusted relative risk estimates published in the English language on the association between nut consumption and hypertension risk. Random effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs) for the association between nut consumption and hypertension. We used World Cancer Research Fund (WCRF) criteria to assess the strength of the evidence. Eight studies (20,665 cases, x) were included in the meta-analysis. The summary RR for the highest vs. lowest category of nut intake was 0.84 (95% CI: 0.77-0.91, I2=50%, pheterogeneity=0.05, n=8) and per 28 g/d was 0.80 (95% CI: 0.71-0.89, I2=75%, pheterogeneity<0.0001, n=8). There was no indication of publication bias with Begg's test (p=0.71) or Egger's test (p=0.10) or by visual inspection of the funnel plot. There was some indication of nonlinearity (pnonlinearity=0.07) and there was a 26% reduction in risk when comparing 30g/d vs. 0 g/d. Using WCRF criteria to assess the strength of evidence, we graded the likelihood of causality as probable. In this meta-analysis of prospective cohort studies, we found further evidence for a reduced risk of hypertension with higher intake of nuts. These findings support dietary guideline recommendations to include a serving of nuts per day.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-22"},"PeriodicalIF":3.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum n-3 fatty acids and obesity-comorbid depression in US adults: an integrated epidemiology and network pharmacology study. 美国成人血清Omega-3脂肪酸与肥胖-共病性抑郁症：一项综合流行病学和网络药理学研究

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-04 DOI: 10.1017/S0007114526108198

Gexin Gao, Enyu Lou, Ya Chen, Haoran Zhang, Heng Lan, Jungu Jin, Yu-Hsin Chen, Halliru Zailani, Ayesha Zafar Iqbal, Wei Chen, Qingxi Jiang, Jia Li, Kuan-Pin Su, Bo Yang

{"title":"Serum n-3 fatty acids and obesity-comorbid depression in US adults: an integrated epidemiology and network pharmacology study.","authors":"Gexin Gao, Enyu Lou, Ya Chen, Haoran Zhang, Heng Lan, Jungu Jin, Yu-Hsin Chen, Halliru Zailani, Ayesha Zafar Iqbal, Wei Chen, Qingxi Jiang, Jia Li, Kuan-Pin Su, Bo Yang","doi":"10.1017/S0007114526108198","DOIUrl":"10.1017/S0007114526108198","url":null,"abstract":"n-3 PUFA, DHA and EPA possess anti-inflammatory properties, yet their association with obesity-depression comorbidity remains unclear. This study investigated the association among USA adults and explored underlying mechanisms. We performed a cross-sectional analysis of 4,423 adults participating in the National Health and Nutrition Examination Survey 2003-2004 and 2011-2014. Serum fatty acids were quantified by gas chromatography. Obesity was defined using anthropometric criteria, and depression was assessed using the Patient Health Questionnaire-9 or antidepressant use. Multivariable logistic regression estimated odds ratio (OR) per sd increase in PUFA levels. Mechanistic explore through network pharmacology identified potential pathways, which were examined using correlation analyses with inflammatory indices. Higher n-3 PUFA levels were associated with lower odds of central obesity comorbid depression in females (OR: 0·82, 95 % CI: 0·69-0·96) and older adults (OR: 0·79, 95 % CI: 0·64-0·97). DHA was significantly associated with lower odds of central obesity (OR: 0·83, 95 % CI: 0·73-0·95), depressive symptoms (OR: 0·88, 95 % CI: 0·77-1·00) and their comorbidity (OR: 0·85, 95 % CI: 0·74-0·98), whereas no significant associations were found for EPA. Mechanistic exploration implicated DHA in TNF and IL-17 signalling pathways, supported by inverse correlations with monocyte:HDL ratio (r: -0·138, P < 0·001) and lymphocyte:HDL ratio (r: -0·108, P < 0·001). In conclusion, serum DHA is inversely associated with obesity-depression comorbidity, with potential involvement of anti-inflammatory pathways. These findings underscore the potential of DHA for the management of obesity comorbid depression and the need for further interventional trials.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of non-nutritive sweetened beverages versus water on body weight: long-term results of a randomised controlled trial. 无营养甜味饮料与水对体重的影响：一项随机对照试验的长期结果。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-04 DOI: 10.1017/S0007114526108150

Joanne A Harrold, Scott Hill, Cristina Radu, Paul Thomas, Paula Thorp, Charlotte A Hardman, Paul Christiansen, Una Masic, Lauren McGale, Daniel J Cuthbertson, Jason C G Halford

{"title":"Effect of non-nutritive sweetened beverages versus water on body weight: long-term results of a randomised controlled trial.","authors":"Joanne A Harrold, Scott Hill, Cristina Radu, Paul Thomas, Paula Thorp, Charlotte A Hardman, Paul Christiansen, Una Masic, Lauren McGale, Daniel J Cuthbertson, Jason C G Halford","doi":"10.1017/S0007114526108150","DOIUrl":"https://doi.org/10.1017/S0007114526108150","url":null,"abstract":"The aim of this study was to provide robust evidence on the long-term use of non-nutritive sweetened (NNS) beverages on weight management, by comparing NNS beverages and water during 1 year of assisted weight management followed by a voluntary, unassisted 1-year extension. In this parallel-group, open-label, controlled equivalence trial, 493 adults with body mass index 27-35 kg/m2 who regularly consumed cold beverages were randomised 1:1 to water (n 246) or NNS beverages (n 247). Participants joined a group behavioural weight-management programme comprising assisted meetings weekly (12-week weight-loss phase) then monthly (40-week weight-maintenance phase), followed by unassisted monitoring for 52 weeks with a final meeting at week 104. The final 52 week unassisted phase was completed by 220 participants (water: n 117; NNS beverages: n 103), 27·7% of whom were NNS beverage-naïve (naïve was defined as NNS beverages comprising ≤ 25% of beverages in the 5 years before screening). In the unassisted monitoring phase, the primary endpoint was weight change from baseline at week 104 (equivalence: two-sided P > 0·05). Participants consuming water maintained a weight loss of 3·7 kg over 104 weeks, compared with 4·8 kg with NNS beverages; the between-group difference was not significant. After the final 52-week unassisted phase of the 104-week behavioural weight-management programme, water and NNS beverages showed equivalence regarding weight change from baseline. Our findings suggest people can lose weight, and maintain it for two years, when drinking either NNS beverages or water and taking part in weight-management programmes.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-26"},"PeriodicalIF":3.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0