British Journal of Nutrition最新文献_第6页

Reporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-30 DOI: 10.1017/S000711452500011X

Kelly Pozzer Zucatti, Aline Cattani, Flávia Moraes Silva

{"title":"Reporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).","authors":"Kelly Pozzer Zucatti, Aline Cattani, Flávia Moraes Silva","doi":"10.1017/S000711452500011X","DOIUrl":"https://doi.org/10.1017/S000711452500011X","url":null,"abstract":"Studies have demonstrated that the quality and transparency of reporting Clinical Practice Guidelines (CPGs) in healthcare are low. This meta-research aimed to evaluate the adherence of nutrition CPGs for critically ill adults to the reporting RIGHT checklist and its association with the methodological quality assessed by AGREE II, along with other potential publication-related factors. A systematic search for CPGs until December 2024 was conducted. RIGHT and AGREE II were applied. Reporting completeness score was created using the data from the evaluations of whether each broken-down item of the RIGHT. Eleven CPGs were identified, none demonstrated adherence greater than 60% to the RIGHT checklist, and the mean of RIGHT score was 33.5±15.5%. There was a strong correlation between the RIGHT score and AGREE II (r=0.886). A development CPGs team including methodologist and/or statistician was associated with a higher RIGHT score (48.9±4.5 versus 27.2±11.0) and it was higher in CPGs recommended or recommended with modifications by AGREE II in comparison to those not recommended (50.1±4.6 versus 37.7±8.1 versus 17.0±6.8), and in those with acceptable and moderate compared to those with low methodological quality (50.1±4.6 versus 32.2±14.5 versus 19.3±6.2). It was also related to the language of publication, being higher in those published in English. The reporting completeness in CPGs for critically ill adults was low, with a strong correlation with the methodological quality. High values of reporting completeness scores were observed between CPGs recommended by AGREE II (with moderate or acceptable quality) and in those including a methodologist/statistician in the development team.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-38"},"PeriodicalIF":3.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tryptophan regulates food intake in growing pigs by modulating hypothalamic AMPK-mTOR signalling pathway. 色氨酸通过调节下丘脑AMPK-mTOR信号通路调节生长猪的摄食。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-13 DOI: 10.1017/S0007114524003210

Juexin Fan, Yuezhou Yao, Leli Wang, Feiyue Chen, Zhenguo Hu, Kaihuan Xie, Shuzhong Jiang, Xiongzhuo Tang

{"title":"Tryptophan regulates food intake in growing pigs by modulating hypothalamic AMPK-mTOR signalling pathway.","authors":"Juexin Fan, Yuezhou Yao, Leli Wang, Feiyue Chen, Zhenguo Hu, Kaihuan Xie, Shuzhong Jiang, Xiongzhuo Tang","doi":"10.1017/S0007114524003210","DOIUrl":"10.1017/S0007114524003210","url":null,"abstract":"Tryptophan (Trp) is an essential amino acid acting as a key nutrition factor regulating animal growth and development. But how Trp modulates food intake in pigs is still not well known. Here, we investigated the effect of dietary supplementation of Trp with different levels on food intake of growing pigs. The data showed that dietary Trp supplementation with the standardised ileal digestibility (SID) Trp to lysine (Lys) ratio at both 0·18 and 0·20 significantly increased the food intake by activating the expression of orexigenic gene agouti-related peptide (AgRP) and inhibiting the expression of anorexigenic gene pro-opiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART) and melanocortin receptor 4 (MC4R) in the hypothalamus. Meanwhile, the level of anorexigenic hormones appetite-regulating peptide YY (PYY) in the duodenum and serum and leptin receptor in the duodenum were also significantly decreased. Importantly, both the kynurenine and serotonin metabolic pathways were activated upon dietary Trp supplementation to downregulate MC4R expression in the hypothalamus. Further mechanistic studies revealed that the reduced MC4R expression activated the hypothalamic AMP-activated protein kinase (AMPK) pathway, which in turn inhibited the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) activity to stimulate food intake. Together, our study unravels the orexigenic effect of dietary Trp supplementation in pigs and expands its potential application in developing nutrition intervention strategy in pig production.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"269-276"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal dependency on maternal fatty acids: a pilot study in human pregnancies using the natural abundance variation of ¹³C. 胎儿对母体脂肪酸的依赖性：利用13C的自然丰度变化在人类妊娠中的初步研究。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-16 DOI: 10.1017/S0007114524003222

Simonato Manuela, Verlato Giovanna, Visentin Silvia, Erich Cosmi, Anna Sartori, Pieter Sauer, Alessio Correani, Cogo Paola, Carnielli Virgilio

{"title":"Fetal dependency on maternal fatty acids: a pilot study in human pregnancies using the natural abundance variation of 13C.","authors":"Simonato Manuela, Verlato Giovanna, Visentin Silvia, Erich Cosmi, Anna Sartori, Pieter Sauer, Alessio Correani, Cogo Paola, Carnielli Virgilio","doi":"10.1017/S0007114524003222","DOIUrl":"10.1017/S0007114524003222","url":null,"abstract":"The extent of de-novo biosynthesis of non-essential fatty acids (FA) and the endogenous biosynthesis of long chain PUFA in human fetuses remain largely unknown. We used natural variations in the 13C:12C (δ 13C) of plasma phospholipids of the woman at delivery and of cord blood to infer fetal biosynthesis of FA. We studied thirty-nine mother-fetus pairs with uncomplicated pregnancies and term delivery. Eighteen women were supplemented with DHA, from pregnancy week 20 until delivery, sourced from an algae (n 13) or fish oil (n 5), each with slightly different 13C content. Twenty-one women did not receive DHA supplementation. We measured the δ 13C value of selected phospholipid FA (C16:0, C18:0, C18:1n-9, C18:2n-6, C20:4n-6 and C22:6n-3) in maternal and cord plasma samples at delivery using isotope ratio MS. We found significant linear correlations for δ 13C values of FA between mothers and their fetuses (C16:0, r = 0·8535; C18:0, r = 0·9099; C18:1n-9, r = 0·8079; C18:2n-6, r = 0·9466; C20:4n-6, r = 0·9257 and C22:6n-3, r = 0·9706). Women supplemented with algal DHA had significantly lower DHA δ 13C values in their plasma phospholipids than those supplemented with fish DHA or those who did not receive DHA supplementation (P < 0·001). There was no significant difference in δ 13C values of FA between women at delivery and their fetuses. These findings strongly suggest that the human fetus is highly dependent on the placental transport of maternal plasma FA, particularly DHA. The limited fetal biosynthesis of major FA emphasises the crucial role of maternal nutrition and placental well-being in fetal development.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"194-201"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient digestion efficiency: a comparison between broiler chickens and growing pigs fed maize, barley and oats-based diets with an emphasis on starch. 营养物质消化效率：以玉米、大麦和燕麦为基础，以淀粉为重点的饲粮的肉鸡和生长猪的比较

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-13 DOI: 10.1017/S0007114524003167

Lucas S Bassi, Marcin Hejdysz, Ewa Pruszyńska-Oszmałek, Paweł A Kołodziejski, Aaron J Cowieson, Sebastian A Kaczmarek, Birger Svihus

{"title":"Nutrient digestion efficiency: a comparison between broiler chickens and growing pigs fed maize, barley and oats-based diets with an emphasis on starch.","authors":"Lucas S Bassi, Marcin Hejdysz, Ewa Pruszyńska-Oszmałek, Paweł A Kołodziejski, Aaron J Cowieson, Sebastian A Kaczmarek, Birger Svihus","doi":"10.1017/S0007114524003167","DOIUrl":"10.1017/S0007114524003167","url":null,"abstract":"We investigated the hypotheses that broilers and pigs have distinct starch digestion capacities and that different cereals could trigger diet-species interactions. Ten replicates of two broilers (14 d old) or one pig (50 d old) each were distributed into a 3 × 2 randomised factorial design with three pelleted diets (maize, barley or oat-based) and the two species. Nutritional composition was equal for both species. Diets were fed for 10 d, and then the pancreas and organs from the stomach region and small intestine were collected with contents. It was observed that both species were similarly efficient at digesting starch but differed in some digestive aspects. Broilers had higher ileal digestibility coefficients (P < 0·001) of DM (0·69) and crude protein (0·75) than pigs (0·66 and 0·67), presented a higher volume of particles < 0·1 mm in duodenal digesta (P < 0·001) and had a lower gizzard pH (3·68) than pig stomach (4·48; P < 0·05). Conversely, pigs had lower ileal viscosity (1·44 v. 2·77 cP; P < 0·05) and higher pancreatic lipase activity (27 v. 5·9 U/g of pancreas; P < 0·05) compared with broilers. In the jejunum, oat led to higher starch digestibility (0·96; P < 0·05) than maize and barley regardless of species. In the ileum, starch digestibility was higher for broilers fed oats (0·99) than broilers fed barley (0·94; P < 0·05), establishing that oats provided, in general, a superior starch availability. The results imply that starch utilisation capacity is more related to its dietary source than to the species to which it is fed.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"182-193"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with rheumatoid arthritis: a case-control study. 成年女性类风湿关节炎患者血清总抗氧化水平、营养状况和地中海饮食依从性的评价：一项病例对照研究

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2025-01-06 DOI: 10.1017/S0007114524003386

Cansu Bekar, Berkan Armagan, Alper Sari, Aylin Ayaz

{"title":"Evaluation of serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with rheumatoid arthritis: a case-control study.","authors":"Cansu Bekar, Berkan Armagan, Alper Sari, Aylin Ayaz","doi":"10.1017/S0007114524003386","DOIUrl":"10.1017/S0007114524003386","url":null,"abstract":"Rheumatoid arthritis (RA) is characterised by chronic inflammation in joints. Obesity, stress, being women and dietary pattern are important in pathogenesis. The joint damage in RA is accelerated by oxidative stress. The aim of this study was to examine the serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with RA. Thirty-five adult women RA patients and thirty-five healthy control participated in this study (45·4 ± 11·61 and 42·5 ± 8·50 years, respectively). Nutritional status, physical activity levels and adherence to the Mediterranean diet were questioned. Physicians assessed the disease activity score of patients with RA. Serum total antioxidant and oxidant status were analysed. The serum total antioxidant status of the control group was higher, whereas the oxidative stress index and total oxidant status were lower than that of the RA group. Dietary protein, fibre, EPA, retinol, Fe, Zn and total antioxidant intake in the RA group were lower than in the control group (P < 0·05). Individuals with higher fibre intake showed a significantly lower risk for RA after adjusting for potential confounding factors (OR = 0·845, 95 % CI = 0·773-0·923, P < 0·001). The mean physical activity level of the control group was higher than that of the RA group (1·59 ± 0·10 and 1·53 ± 0·13, respectively) (P = 0·01). In conclusion, serum antioxidant parameters and dietary antioxidant intake are decreased in patients with RA. Therefore, medical treatment for these patients should be supplemented with medical nutrition therapy to achieve optimal nutritional status.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"239-245"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foods provided at shelters during a heavy rain disaster: comparison of weighed food records between different numbers of days. 暴雨灾害中避难所提供的食物：不同天数间称重食物记录的比较。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-11-29 DOI: 10.1017/S0007114524003088

Hiroka Sato, Noriko Sudo, Sayaka Nagao-Sato, Nobuyo Tsuboyama-Kasaoka

{"title":"Foods provided at shelters during a heavy rain disaster: comparison of weighed food records between different numbers of days.","authors":"Hiroka Sato, Noriko Sudo, Sayaka Nagao-Sato, Nobuyo Tsuboyama-Kasaoka","doi":"10.1017/S0007114524003088","DOIUrl":"10.1017/S0007114524003088","url":null,"abstract":"Dietitians working at evacuation shelters conduct weighed food records (WFR) for multiple days for dietary assessment. Because the menus in evacuation shelters do not change much from day to day, this study examined whether 1- and 2-d WFR are sufficient for dietary assessment at shelters and identified dietary components that can influence the number of assessment days. Overall, twenty-six WFR were collected from ten shelters in Kumamoto Prefecture, and the amounts of energy; protein; vitamins B1, B2 and C and salt were calculated. Correlation analysis and paired sample tests were conducted to examine significant differences between 'one- and two-consecutive- or non-consecutive-day WFR' and 'three-consecutive-day WFR', which were set as the standard in this study. Additionally, the (CV for the categories by meal and dish were calculated to examine the variables that affected the large variations. As a result, 1-d WFR had significant positive correlations with the standard; thus, it could be used for the triage of shelters requiring nutrition assistance as a substitute for 3-d WFR. Two-consecutive-day and non-consecutive-day WFR showed a stronger correlation with the standard compared with the 1-d WFR. For energy and nutrients and dish categories, ready-to-eat foods had larger CV than boxed meals or foods from hot meal services. Whenever the meals included ready-to-eat foods, a two-non-consecutive-day WFR is recommended considering large between-day variations. Salty soup or beverages affected the variation of some nutrients. Our result would help municipalities to consider the number of WFR during emergency.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"253-261"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of food addiction and its association with type 2 diabetes: a systematic review with meta-analysis.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 DOI: 10.1017/S000711452500008X

André Eduardo da Silva-Júnior, Mateus de Lima Macena, Nassib Bezerra Bueno

{"title":"The prevalence of food addiction and its association with type 2 diabetes: a systematic review with meta-analysis.","authors":"André Eduardo da Silva-Júnior, Mateus de Lima Macena, Nassib Bezerra Bueno","doi":"10.1017/S000711452500008X","DOIUrl":"10.1017/S000711452500008X","url":null,"abstract":"The study aim was to determine the prevalence of food addiction (FA) in individuals with type 2 diabetes and to assess the association between FA and type 2 diabetes. MEDLINE, EMBASE, Web of Sciences, Latin American and Caribbean Literature in Health Sciences, ScienceDirect, Scopus and PsycINFO were searched until November 2024. This study was registered with PROSPERO (CRD42023465903). Cross-sectional studies, case-control, cohorts and clinical trials that were carried out with individuals with type 2 diabetes, regardless of age and sex, were included. The complete data extracted included the prevalence, OR and/or risk ratio of FA, the number of individuals evaluated, age, sex, weight, presence of co-morbidities, age of participants and FA symptoms. A pooled prevalence of FA of 30 % (95 % CI (18, 44) with estimated predictive interval (0; 85); I2 = 99·51; 12 studies; 15 947 participants) was identified. For the associations between FA and type 2 diabetes, we found a grouped crude OR value of 2·35 (95 % CI (1·71, 2·98)). The pooled OR adjusted for age and sex was 2·60 (95 % CI (1·77, 3·42)). Finally, the OR adjusted for age, sex and BMI was 2·01 (95 % CI (1·39, 2·64)). The results of the meta-analyses showed a high prevalence of FA in individuals with type 2 diabetes and that the associations between these two conditions remained even after adjustment for age, sex and BMI, although with a high heterogeneity among individual estimates.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on 'Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy'. 评论“头颈癌患者的肌肉减少性肥胖是放疗期间临界体重减轻的预测指标”。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-20 DOI: 10.1017/S0007114524003039

Erkan Topkan, Efsun Somay, Duriye Ozturk, Ugur Selek

引用次数: 0

The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial. 辅酶Q10预处理对子宫切除双侧输卵管切除术妇女卵巢储备的影响：一项随机、双盲、安慰剂对照试验

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-09 DOI: 10.1017/S0007114524003131

Kanockpetch Micaraseth, Siriluk Tantanavipas, Woradej Hongsakorn, Artitaya Singwongsa

{"title":"The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial.","authors":"Kanockpetch Micaraseth, Siriluk Tantanavipas, Woradej Hongsakorn, Artitaya Singwongsa","doi":"10.1017/S0007114524003131","DOIUrl":"10.1017/S0007114524003131","url":null,"abstract":"The effect of diminished ovarian reserves after undergoing hysterectomies with bilateral salpingectomies is one of the health concerns among reproductive-age women with benign gynecological diseases. Coenzyme Q10 (CoQ10), an antioxidant, is crucial in mitochondrial energy production, improving oocyte quality and quantity. This study compares the benefit of a 14-d preoperative (CoQ10) v. placebo on ovarian reserve by measuring anti-Müllerian hormone (AMH) in women undergoing hysterectomy with bilateral salpingectomy. A double-blinded, randomised, placebo-controlled trial was conducted. Forty-four women with benign gynecological diseases were randomised to receive either oral CoQ10 300 mg per d or placebo for 14 d before undergoing hysterectomy with bilateral salpingectomy. Serum AMH levels were collected for analysis before taking CoQ10 and 6 weeks postoperatively in each group. The baseline demographic, clinical characteristics and baseline AMH levels were comparable between the groups (1·47 (0·45, 2·49) v. 1·29 (0·47, 2·11), P = 0·763). The serum AMH levels after the surgery were significantly decreased from preoperative levels (median 0·99 (0·37, 1·63) v. 1·34 (0·57, 2·30)), P = 0·001. However, there was no significant difference in the AMH change between the CoQ10 group and the placebo group (AMH per cent change -28·2 % (64·09, -4·81) v. -20·07 % (-61·51, -2·92)), P = 0·99, respectively. Age, gynecological disease, operative time and blood loss were not significantly associated with the AMH change. There were no significant side effects or adverse operative outcomes among CoQ10 users. In conclusion, hysterectomy with bilateral salpingectomy led to a significantly decreased AMH level. However, pretreatment with CoQ10 for 2 weeks was ineffective in protecting an ovarian reserve.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"213-220"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of the Global Leadership Initiative on Malnutrition criteria including systemic inflammation in patients with advanced cancer. 包括系统性炎症在内的GLIM标准在晚期癌症患者中的预后价值。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2025-01-08 DOI: 10.1017/S0007114524003271

Bruna M M Rocha, Josh McGovern, Carlos E Paiva, Ross D Dolan, Bianca S R Paiva, Daniel D Preto, Barry J Laird, Yara C P Maia, Donald C McMillan

{"title":"Prognostic value of the Global Leadership Initiative on Malnutrition criteria including systemic inflammation in patients with advanced cancer.","authors":"Bruna M M Rocha, Josh McGovern, Carlos E Paiva, Ross D Dolan, Bianca S R Paiva, Daniel D Preto, Barry J Laird, Yara C P Maia, Donald C McMillan","doi":"10.1017/S0007114524003271","DOIUrl":"10.1017/S0007114524003271","url":null,"abstract":"An assessment of systemic inflammation and nutritional status may form the basis of a framework to examine the prognostic value of cachexia in patients with advanced cancer. The objective of the study was to examine the prognostic value of the Global Leadership Initiative on Malnutrition criteria, including BMI, weight loss (WL) and systemic inflammation (as measured by the modified Glasgow Prognostic Score (mGPS)), in advanced cancer patients. Three criteria were examined in a combined cohort of patients with advanced cancer, and their relationship with survival was examined using Cox regression methods. Data were available on 1303 patients. Considering BMI and the mGPS, the 3-month survival rate varied from 74 % (BMI > 28 kg/m2) to 61 % (BMI < 20 kg/m2) and from 84 % (mGPS 0) to 60 % (mGPS 2). Considering WL and the mGPS, the 3-month survival rate varied from 81 % (WL ± 2·4 %) to 47 % (WL ≥ 15 %) and from 93 % (mGPS 0) to 60 % (mGPS 2). Considering BMI/WL grade and mGPS, the 3-month survival rate varied from 86 % (BMI/WL grade 0) to 59 % (BMI/WL grade 4) and from 93 % (mGPS 0) to 63 % (mGPS 2). When these criteria were combined, they better predicted survival. On multivariate survival analysis, the most highly predictive factors were BMI/WL grade 3 (HR 1·454, P = 0·004), BMI/WL grade 4 (HR 2·285, P < 0·001) and mGPS 1 and 2 (HR 1·889, HR 2·545, all P < 0·001). In summary, a high BMI/WL grade and a high mGPS as outlined in the BMI/WL grade/mGPS framework were consistently associated with poorer survival of patients with advanced cancer. It can be readily incorporated into the routine assessment of patients.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"246-252"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0