British Journal of Nutrition最新文献

Impact of (poly)phenol-rich dietary sources on DNA damage: Insights from human intervention studies using the Comet assay - a review and perspective.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-07 DOI: 10.1017/S000711452500073X

Misko Milev, Boris Roglev, Maria Kondeva Rogleva, Milena Georgieva, George Miloshev, Tatjana Ruskovska

{"title":"Impact of (poly)phenol-rich dietary sources on DNA damage: Insights from human intervention studies using the Comet assay - a review and perspective.","authors":"Misko Milev, Boris Roglev, Maria Kondeva Rogleva, Milena Georgieva, George Miloshev, Tatjana Ruskovska","doi":"10.1017/S000711452500073X","DOIUrl":"https://doi.org/10.1017/S000711452500073X","url":null,"abstract":"(Poly)phenols are plant-derived food bioactives abundantly present in human diet. They exert positive effects on various aspects of human health, and in particular in reducing the risk of chronic non-communicable diseases. Dietary (poly)phenols have been reported to improve vascular function, blood lipids, insulin sensitivity, and to decrease systemic inflammation. Evidence also suggests that (poly)phenols may exert protective effects on DNA, by reducing the extent of its damage. In recent years, advanced analytical methods, including transcriptomics, metabolomics, proteomics, and metagenomics, have been employed to unravel the complex impact of (poly)phenols in health and disease. Advances in bioinformatics enable an integrated multi-omics approach to data analysis, opening avenues for discovering new, previously unknown molecular mechanisms of action. Innovative solutions and automation of the Comet assay offer new opportunities for more in-depth analysis of the impact of (poly)phenols on DNA damage and its inclusion in integrative bioinformatic models. Such an approach has the potential to uncover new multi-level interactions and to reveal previously unknown factors underlying inter-individual variabilities in health-promoting effects of (poly)phenols. This review provides an insight into the application of the Comet assay in human intervention studies using (poly)phenol-rich dietary sources. Recent advancements in the Comet assay technology, and the prospects for more extensive use of this method in future human intervention studies with (poly)phenols could contribute to the development of personalized dietary recommendations for these plant-derived food bioactives.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-40"},"PeriodicalIF":3.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variability of plasma/serum and erythrocyte selenium in the first year of life: a systematic review.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-07 DOI: 10.1017/S0007114525000728

Cláudia B de Almeida, Taís T Silveira, Heitor P Leite, Tulio Konstantyner, Yara M F Moreno

{"title":"Variability of plasma/serum and erythrocyte selenium in the first year of life: a systematic review.","authors":"Cláudia B de Almeida, Taís T Silveira, Heitor P Leite, Tulio Konstantyner, Yara M F Moreno","doi":"10.1017/S0007114525000728","DOIUrl":"https://doi.org/10.1017/S0007114525000728","url":null,"abstract":"Selenium is particularly necessary in infants because of their rapid physical growth period in addition to being indispensable for neurodevelopment. Severe deficiency can lead to cardiomyopathy, hypothyroidism and faltering growth. However, selenium can be toxic at high doses. In the pediatric age group, plasma/serum and erythrocyte selenium levels seem to increase with age, except in the first year of life. Understanding the variability in selenium status during this period can help to identify infants at risk of deficiency and develop strategies for controlling and preventing its consequences. This review aimed to identify the extent and characteristics of the variability of selenium status during the first year of life. A search was conducted across five databases to find articles published until July 30, 2024, with no limitations on the language or date of publication. Articles were screened, data were extracted independently by two reviewers, and any disagreement was resolved by a third reviewer. A total of 22 studies comprising 1288 participants were included in this review, 21 of which assessed plasma/serum selenium and 12 assessed erythrocyte selenium. In the first four months of age, serum/plasma selenium decreased, remained stable, or increased depending on feeding, with an increase in supplemented formula-fed infants and breastfed infants of supplemented mothers. Erythrocyte selenium levels showed a declining trend, except in infants fed supplemented formula or breastfed by supplemented mothers. Variability of serum/plasma and erythrocyte selenium levels in the first year was associated with maternal selenium intake/supplementation and the selenium content of the infant's diet.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-36"},"PeriodicalIF":3.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthful Plant-Based Dietary Patterns, PM_2.5 Exposure, and the Risk of Heart Failure: a Population Based Cohort Study.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-04 DOI: 10.1017/S0007114525000698

Shenshen Zhu, Xiaoqing Zhang, Zhaoke Wu, Yuefei Jin, Weidong Wu, Junxi Zhang, Xiaolong Zhang, Yacong Bo, Yongjian Zhu, Ling Li

{"title":"Healthful Plant-Based Dietary Patterns, PM2.5 Exposure, and the Risk of Heart Failure: a Population Based Cohort Study.","authors":"Shenshen Zhu, Xiaoqing Zhang, Zhaoke Wu, Yuefei Jin, Weidong Wu, Junxi Zhang, Xiaolong Zhang, Yacong Bo, Yongjian Zhu, Ling Li","doi":"10.1017/S0007114525000698","DOIUrl":"https://doi.org/10.1017/S0007114525000698","url":null,"abstract":"Fine particulate matter (PM2.5) is a known risk factor for heart failure (HF), while plant-based dietary patterns may help reduce HF risk. This study examined the combined impact of PM2.5 exposure and a plant-based diet on HF incidence. A total of 190,092 participants from the UK Biobank were included in this study. HF cases were identified through linkage to the UK National Health Services register, with follow-up lasting until October 2022 in England, August 2022 in Scotland, and May 2022 in Wales. Annual mean PM2.5 concentration was obtained using a land use regression model, while the healthful plant-based diet index (hPDI) was calculated using the Oxford WebQ tool based on two or more 24-hour dietary assessments of 17 major food groups. Cox proportional hazard models assessed the associations of PM2.5 and hPDI with HF risk, and interactions were evaluated on additive and multiplicative scales. During a median of 13.4-year follow-up, 4,351 HF cases were recorded. Participants in the highest PM2.5 tertile had a 23% increased HF risk (HR: 1.23, 95% CI: 1.14-1.32) compared to those in the lowest tertile. Moderate or high hPDI was associated with reduced HF risk relative to low hPDI. The lowest HF risk was observed in individuals with high hPDI and low PM2.5 exposure, underscoring the protective role of a plant-based diet, particularly in areas with lower PM2.5 levels. A healthy plant-based diet may mitigate HF risk, especially in populations exposed to lower PM2.5 levels.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-19"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal Association Between Dietary Factors and Chronic Kidney Disease: A Mendelian Randomization Study.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-04 DOI: 10.1017/S0007114525000765

Ya'nan Huang, Wei Tang, Jianfeng Yang, Zhenhua Zhao

{"title":"Causal Association Between Dietary Factors and Chronic Kidney Disease: A Mendelian Randomization Study.","authors":"Ya'nan Huang, Wei Tang, Jianfeng Yang, Zhenhua Zhao","doi":"10.1017/S0007114525000765","DOIUrl":"https://doi.org/10.1017/S0007114525000765","url":null,"abstract":"Dietary intervention is a key strategy for preventing and managing chronic kidney disease (CKD). However, evidence on specific foods' effects on CKD is limited. This study aims to clarify the impact of various foods on CKD risk. We used two-sample Mendelian randomization (TSMR) to analyze the causal relationships between the intake of 18 foods (e.g., cheese, processed meat, poultry, beef, non-oily fish) and CKD risk, as well as eGFRcr and eGFRcys levels. The inverse variance weighting (IVW) method, weighted median method, MR-Egger regression, simple mode and weighted mode were employed. Sensitivity analysis included Cochran's Q test and the Egger intercept test. Frequent alcohol intake was linked to higher CKD risk (P=0.007, 0.048). Protective factors included cheese (OR=0.71, [95%CI: 0.53, 0.94], P=0.017), tea (OR=0.66, [95%CI: 0.43, 1.00], P=0.048) and dried fruit (OR=0.78, [95%CI: 0.63, 0.98], P=0.033). Oily fish (β=0.051, [95%CI: 0.001, 0.102], p=0.046) and dried fruit (β=0.082, [95%CI: 0.016, 0.149], p=0.014) were associated with elevated eGFRcys. Salad/raw vegetables (β=0.024, [95%CI: 0.003, 0.045], p=0.028) and dried fruit (β=0.013, [95%CI: 0.001, 0.031], p=0.014) were linked to higher eGFRcr, while cereal intake (β=-0.021, [95%CI: -0.033, -0.010], p<0.001) was associated with lower eGFRcr. These findings provide insights for optimizing dietary strategies for CKD patients.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory Analyses of Frequent High-Fat Food Intake in Diets and Its Association with Increased Odds of Atopic Dermatitis in Singapore and Malaysia Young Chinese Adults.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-04 DOI: 10.1017/S0007114525000716

Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew

{"title":"Exploratory Analyses of Frequent High-Fat Food Intake in Diets and Its Association with Increased Odds of Atopic Dermatitis in Singapore and Malaysia Young Chinese Adults.","authors":"Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew","doi":"10.1017/S0007114525000716","DOIUrl":"https://doi.org/10.1017/S0007114525000716","url":null,"abstract":"High-fat food intake is associated with atopic dermatitis (AD), but the role of habitual dietary habits related to the frequency of high-fat food intake remains unclear. To address this, we developed a frequency-based dietary index, Diet Quality based on Dietary Fat Score, to assess high-fat food intake and examined its association with AD in 13,561 young Chinese adults (mean age = 22.51 years, SD ± 5.90) from Singapore and Malaysia. Using an investigator-administered questionnaire aligned with the validated International Study of Asthma and Allergy in Childhood protocol, we conducted multivariable logistic regression adjusting for demographics, body mass index, genetic predisposition, and lifestyle factors, with false discovery rate correction for multiple comparisons. Frequent high-fat food intake was associated with higher odds of AD presentation (Adjusted Odds Ratios [AOR]: 1.525; 95% Confidence Intervals [CI]: 1.314-1.772; adjusted p < 0.001). The association remained significant regardless of total fat intake (AOR: 1.445; 95% CI: 1.054-1.801; adjusted p < 0.001) and among individuals with high fruit and vegetable intake (Adjusted Odds Ratios [AOR]: 1.489; 95% Confidence Intervals [CI]: 1.191-1.860; adjusted p < 0.001) or low energy intake (AOR: 1.399; 95% CI: 1.054-1.857; adjusted p < 0.05). No synergistic effects were observed between dietary factors. These findings highlight that frequent intake of high-fat foods is independently associated with AD, emphasizing the importance of dietary moderation in AD risk management.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-28"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific association between Chinese visceral adiposity index and hyperuricemia among adults: a population-based cross-sectional study in Chongqing, China.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-04 DOI: 10.1017/S0007114525000595

Youxing Luo, Rui Ding, Liling Chen, Yanqi Hu, Meng Xiao, Wenge Tang, Jinfu Qiu, Xiang Liu, Xianbin Ding, Xiaojun Tang

{"title":"Sex-specific association between Chinese visceral adiposity index and hyperuricemia among adults: a population-based cross-sectional study in Chongqing, China.","authors":"Youxing Luo, Rui Ding, Liling Chen, Yanqi Hu, Meng Xiao, Wenge Tang, Jinfu Qiu, Xiang Liu, Xianbin Ding, Xiaojun Tang","doi":"10.1017/S0007114525000595","DOIUrl":"https://doi.org/10.1017/S0007114525000595","url":null,"abstract":"Research on the association between the Chinese visceral adiposity index (CVAI) and hyperuricemia (HUA) is scarce, and whether the association differs by sex is unclear. This research aimed to explore sex-specific associations between CVAI and HUA and to compare CVAI's predictive performance with other adiposity indices using data from 22,171 adults (30-79 years) in the China Multi-Ethnic Cohort (CMEC) study (Chongqing region). The prevalence of HUA was 20.9% in men and 9.7% in women. Multivariable logistic regression analyses were utilized to assess the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). After multivariable adjustment, CVAI was associated with HUA in men (OR Q4 vs. Q1 = 3.31, 95% CI 2.73, 4.03) and women (OR Q4 vs. Q1 = 7.20, 95% CI 5.12, 10.12). Moreover, Significant interactions were observed between BMI and CVAI on HUA in both sexes (all Pinteraction <0.001), with the strongest associations in those with BMI <24.0 kg/m2. The ORs (95% CI) across different BMI groups (<24.0, 24.0-27.9, ≥28.0 kg/m²) were 1.87 (1.63, 2.13), 1.65 (1.48, 1.85), and 1.30 (1.14, 1.49) for men, and 2.76 (2.18, 3.51), 2.46 (1.98, 3.07), and 1.87 (1.47, 2.39) for women, respectively. Additionally, CVAI showed satisfactory predictive performance for HUA in women, with the largest area under the receiver operating characteristic curve (AUROC) of 0.735, but not in men (0.660). These findings suggest a close association between CVAI and HUA, particularly pronounced in those with BMI <24.0 kg/m², and a stronger association in women than in men.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-29"},"PeriodicalIF":3.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Causal Association between Malnutrition, Overweight and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-04-03 DOI: 10.1017/S0007114525000704

Yan Wang, Jian Shi

{"title":"Genetic Causal Association between Malnutrition, Overweight and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study.","authors":"Yan Wang, Jian Shi","doi":"10.1017/S0007114525000704","DOIUrl":"https://doi.org/10.1017/S0007114525000704","url":null,"abstract":"Despite previous observational studies suggesting that malnutrition could be involved in venous thromboembolism (VTE), definitive causality still lacks in high-quality research evidence. This study aims to explore the genetic causal association between malnutrition and VTE. The study was performed using summary statistics from genome-wide association studies (GWAS) for VTE (cases =23,367; controls =430,366). Single nucleotide polymorphism (SNP) associated with exposure was selected based on quality control steps. The primary analysis employed the Inverse-variance weighted (IVW) method, with additional support from MR-Egger, weighted median, and weighted mode approaches. MR-Egger, leave-one-SNP-out analysis and MR-PRESSO was used for sensitivity analysis. Cochran's Q test was used to assess heterogeneity between instrumental variables (IVs). IVW suggested that overweight have a positive genetic casual effect on VTE (OR=1.1344, 95% CI= 1.056-1.2186, p<0.001). No genetic casual effect of malnutrition (IVW: OR=0.9983, 95% CI= 0.9593-1.0388, p=0.9333) was found on VTE. Cochran's Q test suggests no possible heterogeneity in both related exposures. The results of the MR-Egger regression suggest that the analysis is not affected by horizontal pleiotropy. The results of the MR-PRESSO suggest that there are no outliers. The results revealed a statistical genetical association where overweight correlate with an increased risk of VTE. Meanwhile, no genetical causal link was observed between malnutrition and VTE. Further research is warranted to deepen our understanding of these associations.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-20"},"PeriodicalIF":3.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coenzyme Q10 mitigates high-fat-diet-induced hepatic steatosis in spotted bass (Lateolabrax maculatus) through modulating mitochondrial function.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-03-31 DOI: 10.1017/S0007114525000637

Xiaojiang Mao, Xueshan Li, Ling Wang, Kai Song, Chunxiao Zhang, Bei Huang, Kangle Lu, Samad Rahimnejad

{"title":"Coenzyme Q10 mitigates high-fat-diet-induced hepatic steatosis in spotted bass (Lateolabrax maculatus) through modulating mitochondrial function.","authors":"Xiaojiang Mao, Xueshan Li, Ling Wang, Kai Song, Chunxiao Zhang, Bei Huang, Kangle Lu, Samad Rahimnejad","doi":"10.1017/S0007114525000637","DOIUrl":"https://doi.org/10.1017/S0007114525000637","url":null,"abstract":"This study elucidated the impacts of coenzyme Q10 (COQ10) supplementation in a high-fat diet on growth, lipid metabolism, and mitochondrial function in spotted seabass (Lateolabrax maculatus). Totally five diets were formulated: a diet with normal fat content (11% lipid, NFD), a high-fat diet (17% lipid, HFD), and three additional diets by supplementing 5, 20 or 80 mg/kg of COQ10 to the HFD. After an 8-week culture period, samples were collected and analyzed. The results demonstrated that COQ10 inclusion prevented the HFD-induced deterioration of growth performance and feed utilization. COQ10 alleviated the deposition of saturated fatty acids following HFD intake and promoted the assimilation of n-3 and n-6 polyunsaturated fatty acids. Moreover, COQ10 administration inhibited the surge in serum transaminase activity and reduced hepatic lipid content following HFD ingestion, which was consistent with the results of oil red O staining. In addition, HFD feeding led to reduced hepatic citrate synthase and succinate dehydrogenase activities, and decreased ATP content. Notably, COQ10 administration improved these indices, and up-regulated the expression of mitochondrial biogenesis-related genes (pgc-1α, pgc-1β, nrf-1, tfam) and autophagy-related genes (pink1, mul1, atg5). In summary, supplementing 20-80 mg/kg of COQ10 in the HFD promoted growth performance, alleviated hepatic fat accumulation, and enhanced liver mitochondrial function in spotted seabass.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-43"},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary inflammatory or oxidative stress indices and biomarkers in cardiometabolic and related conditions: A systematic literature review.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-03-31 DOI: 10.1017/S0007114525000686

Charlotte G Peake, Kate Odgers-Jewell, Chantal J de Sousa, Carolyn J English, Ale Ingabire, Hannah L Mayr, Dianne P Reidlinger

{"title":"Association between dietary inflammatory or oxidative stress indices and biomarkers in cardiometabolic and related conditions: A systematic literature review.","authors":"Charlotte G Peake, Kate Odgers-Jewell, Chantal J de Sousa, Carolyn J English, Ale Ingabire, Hannah L Mayr, Dianne P Reidlinger","doi":"10.1017/S0007114525000686","DOIUrl":"https://doi.org/10.1017/S0007114525000686","url":null,"abstract":"Inflammation and oxidative stress contribute to the progression of chronic diseases, and the volume of research in this area is rapidly expanding. Various dietary indices have been developed to determine the overall inflammatory or oxidative stress potential of a diet; however, few have been validated in cardiometabolic disease populations. This review aimed to explore the association between dietary indices and biomarkers of inflammation and oxidative stress in adults with cardiometabolic conditions. Four databases were systematically searched for literature in any language (Embase, CINAHL, CENTRAL, and MEDLINE) with 12,177 deduplicated records identified. Seventeen studies of adults with metabolic syndrome, cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease or chronic kidney disease were included. Fourteen studies were observational studies, one study was a clinical trial, and one was a randomised controlled trial. Four dietary indices were reported on with most studies (n=11) reporting on the dietary inflammatory index. The most reported biomarker was C-reactive protein. The findings were narratively synthesised. Results were inconclusive due to the heterogeneity of dietary indices and their use, disease states, and biomarkers reported. Only one study reporting on the dietary inflammatory index assessed all 45 parameters. Observational studies, particularly retrospective designs (n=7) are subject to recall and selection biases, potentially presenting overestimated results. Further research is required to determine the relationship between dietary indices and biomarkers of inflammation and oxidative stress in cardiometabolic disease populations. Future research should be rigorous, prospective, assess the full range of index parameters, and examine biomarkers the tool was developed for.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-46"},"PeriodicalIF":3.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between the metabolic syndrome and the irritable bowel syndrome: A cross-sectional study among a sample of Lebanese adults. 代谢综合征与肠易激综合征之间的关系：黎巴嫩成年人样本横断面研究。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-03-28 DOI: 10.1017/S0007114525000650

Myriam Abboud, Suzan Haidar, Nadine Mahboub, Tracy Mamo, Dimitrios Papandreou, Rana Rizk

{"title":"Association between the metabolic syndrome and the irritable bowel syndrome: A cross-sectional study among a sample of Lebanese adults.","authors":"Myriam Abboud, Suzan Haidar, Nadine Mahboub, Tracy Mamo, Dimitrios Papandreou, Rana Rizk","doi":"10.1017/S0007114525000650","DOIUrl":"https://doi.org/10.1017/S0007114525000650","url":null,"abstract":"Evidence of an association between metabolic syndrome (MetS) and irritable bowel syndrome (IBS) is emerging but is still inconclusive. The current cross-sectional study was conducted to explore the relationship between the two syndromes in a sample of Lebanese adults (n=221; mean age: 43.36 years; 62.9% females), recruited from a large urban university and its neighboring community. MetS was diagnosed based on the International Diabetes Federation criteria, and IBS was assessed using the Birmingham IBS scale. Logistic regression analyses were performed taking MetS and its components as dependent variables, and IBS and its subscales as independent variables. Covariates included sociodemographic, dietary, and lifestyle variables. MetS was positively associated with Visual Analogue Scale (VAS)-IBS (total scale (Beta=4.59, p=0.029) and VAS-Diarrhea subscale (Beta=4.96, p=0.008). Elevated blood pressure (Beta=5.02, p=0.007), elevated fasting blood sugar (Beta=4.19, p=0.033), and elevated waist circumference (Beta=5.38, p=0.010) were positively associated with VAS- Diarrhea subscale. MetS and IBS were found to be positively associated in a sample of the Lebanese adult population. We suggest that it might be of value to screen for either condition if one of the syndromes exists. Future longitudinal studies are essential to establish a causal relationship between the two syndromes to further understand the commonality related to pathogenesis and explore potential underlying mechanisms.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-37"},"PeriodicalIF":3.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0