British Journal of Nutrition最新文献

Updating the Scientific Advisory Committee on Nutrition's Framework for the evaluation of evidence. 更新营养科学咨询委员会的证据评估框架。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-31 DOI: 10.1017/S0007114525104054

Mamta Singh, Rachel Elsom, Adrienne Cullum, Russ J de Souza, Darren C Greenwood, David J Mela, Ken K Ong, Ian S Young, Julie A Lovegrove

{"title":"Updating the Scientific Advisory Committee on Nutrition's Framework for the evaluation of evidence.","authors":"Mamta Singh, Rachel Elsom, Adrienne Cullum, Russ J de Souza, Darren C Greenwood, David J Mela, Ken K Ong, Ian S Young, Julie A Lovegrove","doi":"10.1017/S0007114525104054","DOIUrl":"https://doi.org/10.1017/S0007114525104054","url":null,"abstract":"The Scientific Advisory Committee on Nutrition (SACN) provides independent advice on nutrition and related health matters to UK government organisations. In keeping with its commitment to openness and transparency, SACN follows a set 'Framework' to ensure a prescribed and consistent approach is taken in all its evidence evaluations. Following an update of the SACN Framework in 2020, which addressed some straightforward issues, the SACN Framework subgroup was established in 2021 to consider more complex matters that were not addressed in the 2020 update. The SACN Framework subgroup considered 4 main topics for update: 1) the different types of evidence evaluations produced by SACN, 2) interpretation of statistical data, 3) tools for assessment of study quality, 4) tools to assess the certainty of a body of evidence for exposure-outcome relationships. The Framework subgroup agreed clear definitions and processes for the different types of evidence evaluations produced by SACN and agreed that interpretation of p values should be informed by consideration of study size, power and methodological quality. The subgroup recommended use of the AMSTAR 2 tool for quality assessment of evidence from systematic reviews and use of the GRADE approach to assess the certainty of evidence. The updated Framework was published in January 2023. This was followed by publication of a further update in October 2024. As a 'living' document, the Framework will be subject to regular review by the Framework subgroup and continue to evolve in line with best practice.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-16"},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Riboflavin intake modulates the association between passive smoking and hypertension in children and adolescents aged 6-19 years based on the NHANES 2007-2018. 根据NHANES 2007-2018，核黄素摄入量调节6-19岁儿童和青少年被动吸烟与高血压之间的关系。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-31 DOI: 10.1017/S0007114525104078

Xiaoqing Xiong, Jiao Li

{"title":"Riboflavin intake modulates the association between passive smoking and hypertension in children and adolescents aged 6-19 years based on the NHANES 2007-2018.","authors":"Xiaoqing Xiong, Jiao Li","doi":"10.1017/S0007114525104078","DOIUrl":"https://doi.org/10.1017/S0007114525104078","url":null,"abstract":"Passive smoking is associated with an increased risk of hypertension in children. Antioxidant nutrients are known to alleviate oxidative stress, a key factor in the development of hypertension. Riboflavin, with its antioxidant properties, may help mitigate oxidative damage caused by passive smoke exposure. This study aimed to examine whether riboflavin intake could influence the relationship between passive smoking and hypertension in children and adolescents aged 6-19 years. Data were extracted from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) 2007-2018. Weighted logistic regression models were used to identify potential covariates, and weighted multiple logistic regression models assessed the associations between passive smoking, riboflavin intake, and hypertension. The association was also investigated in diverse age, gender, and race subgroups. Results were presented as odds ratios (ORs) and 95% confidence intervals (CIs). 11445 children and adolescents with a mean age of 12.89 (0.06) years were included. After adjusting covariates, cotinine ≥0.05 ng/mL was associated with increased odds of hypertension (OR=1.20, 95%CI: 1.06-1.36). When individuals had a riboflavin intake <1.87 mg, passive smoking (OR=1.98, 95%CI: 1.25-3.13) and active smoking (OR=1.69, 95%CI: 1.14-2.51) were both related to higher odds of hypertension. When individuals had a riboflavin intake ≥1.87 mg, no association was observed between passive smoking (OR=0.83, 95%CI: 0.48-1.44) and active smoking (OR=1.05, 95%CI: 0.68-1.62) and hypertension. Riboflavin intake may modulate the association between smoking status and hypertension in children and adolescents aged 6-19 years. The moderating effect was also found in age <13 years old, ≥13 years old, males, and non-Hispanic Whites.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-22"},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The amino acid composition of commercially available vegan meat and dairy analogues. 市售的纯素肉类和乳制品类似物的氨基酸组成。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-31 DOI: 10.1017/S000711452510408X

Jacintha Domić, Luc Jc van Loon, Els Siebelink, Karin J Borgonjen-van den Berg, Lisette Cpgm de Groot, Pol Grootswagers

{"title":"The amino acid composition of commercially available vegan meat and dairy analogues.","authors":"Jacintha Domić, Luc Jc van Loon, Els Siebelink, Karin J Borgonjen-van den Berg, Lisette Cpgm de Groot, Pol Grootswagers","doi":"10.1017/S000711452510408X","DOIUrl":"https://doi.org/10.1017/S000711452510408X","url":null,"abstract":"Plant-based meat and dairy analogues contain less protein than their animal-based counterparts and rely on various plant protein sources, which frequently display incomplete amino acid (AA) profiles that do not reflect dietary requirements due to low quantities of one or more essential AA (EAA). There is little insight in the AA profiles of most of these plant-based analogues. We assessed the AA composition of 40 plant-based meat and dairy analogues that were commercially available in The Netherlands in March 2023, and compared their EAA profile to dietary requirements and to the EAA profile of their meat and dairy counterparts. Total protein contents were lower in most analogues when compared to their animal-based counterparts (meat analogues, n = 16 (80%); lunch meats and cheese analogues, n = 10 (100%); milk and yoghurt analogues, n = 9 (90%)) and accompanied by lower EAA contents. In reference to dietary requirements, the sum of the total EAA contents was adequate in all but one of the analogues. Nevertheless, all analogues displayed deficiencies in one or more specific EAA. Methionine contents were most frequently low (n = 39; 98%), followed by lysine contents (n = 11; 28%). Essential AA compositions varied between analogues irrespective of the protein source(s) used. In conclusion, plant-based meat and dairy analogues exhibit incomplete EAA profiles, which may compromise adequate protein nutrition in plant-centered diets.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-31"},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a diverse prebiotic fibre supplement on HbA1c, insulin sensitivity and inflammatory biomarkers in pre-diabetes: a pilot placebo-controlled randomised clinical trial - CORRIGENDUM. 多种益生元纤维补充剂对糖尿病前期HbA1c、胰岛素敏感性和炎症生物标志物的影响：一项试验性安慰剂对照随机临床试验-勘误

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-31 DOI: 10.1017/S0007114525102468

C Hall, J Twelves, M Saxena, L Scapozza, T Gurry

引用次数: 0

TNF-α -1031T/C and -863C/A polymorphisms are associated with dyslipidemia. TNF-α -1031T/C和-863C/A多态性与血脂异常有关。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-31 DOI: 10.1017/S000711452510398X

Kaihao Lin, Chaofen Wu, Xin Yao, Xianbin Cai

{"title":"TNF-α -1031T/C and -863C/A polymorphisms are associated with dyslipidemia.","authors":"Kaihao Lin, Chaofen Wu, Xin Yao, Xianbin Cai","doi":"10.1017/S000711452510398X","DOIUrl":"https://doi.org/10.1017/S000711452510398X","url":null,"abstract":"Tumor necrosis factor-α (TNF-α) polymorphisms may influence dyslipidemia, but their role remains unclear. This case-control study investigated associations between TNF-α gene polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A) and dyslipidemia in 595 participants (162 cases, 433 controls) from the Chaoshan region of China. Anthropometric, biochemical, and genetic data were analyzed using Chi-squared tests and logistic regression, with the false discovery rate (FDR) method applied to correct for multiple comparisons. Results revealed that only the -1031T/C and -863C/A polymorphisms were significantly associated with dyslipidemia. Carriers of the TC+CC genotype for -1031T/C (odds ratio [OR]=0.48, 95% CI: 0.30-0.78, PFDR=0.006) and the CA+AA genotype for -863C/A (OR=0.41, 95% CI: 0.24-0.70, PFDR=0.004) had lower odds of dyslipidemia. Protective effects were observed for the C allele at -1031T/C (OR=0.58, PFDR=0.012) and the A allele at -863C/A (OR=0.47, PFDR=0.004). Stratified analyses showed that these associations were significant in males but not females. Functional annotation linked these TNF-α gene polymorphisms to transcription factors (e.g., HNF-1A, STAT1β) in the adipogenesis pathway. This study reveals genetic associations between TNF-α polymorphisms and dyslipidemia, particularly in males, and provides mechanistic insights into their role in transcriptional regulation.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-29"},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1 responses to carbohydrate, fat, and protein in rats during the development of diet-induced obesity and the role of the distal small intestine. 大鼠饮食诱导肥胖过程中GLP-1对碳水化合物、脂肪和蛋白质的反应及远端小肠的作用

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-28 DOI: 10.1017/S0007114525104066

Anri Sano, Satomi Tanaka, Kurumi Yanagiihara, Yasuko Sakihama, Tohru Hira

{"title":"GLP-1 responses to carbohydrate, fat, and protein in rats during the development of diet-induced obesity and the role of the distal small intestine.","authors":"Anri Sano, Satomi Tanaka, Kurumi Yanagiihara, Yasuko Sakihama, Tohru Hira","doi":"10.1017/S0007114525104066","DOIUrl":"https://doi.org/10.1017/S0007114525104066","url":null,"abstract":"The secretion of GLP-1 is stimulated by luminal nutrients after meal ingestion. Diet-induced obesity (DIO) may affect nutrient-induced GLP-1 secretion in humans and rodent models. We previously demonstrated that mixed meal-induced GLP-1 secretion is enhanced in rats with DIO compared to normal rats. However, it is unclear to which nutrient the GLP-1 secretion is adaptively enhanced or reduced during the development of DIO. The present study investigated the effect of obesity on the GLP-1 secretion to individual nutrients and further on GLP-1 secretory functions of the proximal and distal small intestine in rats.Male Sprague-Dawley rats were fed a control diet or a high-fat diet with sucrose solution (HFS) for 4-5 weeks. GLP-1 responses to a single oral administration of a liquid diet, dextrin, soybean oil, or whey protein were examined after 4 weeks of dietary intervention. In addition, a liquid diet was administered to the proximal or distal small intestine of anesthetized rats (control or HFS), and GLP-1 levels in the portal vein plasma were measured.In HFS-fed rats, GLP-1 secretion to dextrin, soybean oil, and whey protein slightly increased compared to those in normal rats. Furthermore, the GLP-1 response to liquid diet administration into the lumen was greater in the distal, but not proximal, small intestine of HFS-fed rats than that in control rats.In rats with DIO, GLP-1 secretion increased, regardless of the type of nutrient. Furthermore, the distal small intestine is responsible for adaptive enhancement of the GLP-1 secretion.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole Grain Intake Remains Unchanged in the United Kingdom, 2008/2012 - 2016/2019. 2008/2012年至2016/2019年，英国全谷物摄入量保持不变。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-28 DOI: 10.1017/S0007114525104091

Inga Kutepova, Colin D Rehm, Samara Joy Smith

{"title":"Whole Grain Intake Remains Unchanged in the United Kingdom, 2008/2012 - 2016/2019.","authors":"Inga Kutepova, Colin D Rehm, Samara Joy Smith","doi":"10.1017/S0007114525104091","DOIUrl":"https://doi.org/10.1017/S0007114525104091","url":null,"abstract":"To address limited data on whole grain (WG) consumption in the UK, we investigated trends and sociodemographic patterns of WG consumption from the National Diet and Nutrition Survey (NDNS) from 2008/12-2016/19 and examined the relationship between WG and dietary intakes. We analysed 15,655 individuals aged ≥1.5 years who completed a four-day food diary. WG consumption was quantified by estimating the WG content of individual foods using publicly available ingredient information. Survey-weighted mean WG consumption over time, and by population sub-group was calculated. Survey-weighted trend tests and Wald tests were used. Total WG intake in the general population did not change from 2008/2012 to 2016/2019. WG from high-fibre cereals and bread declined by 16.2% (11.1 to 9.3g/day) and 19.4% (12.4 to 10g/day) respectively, while other cereals (e.g., rice/pasta) increased by 72.5% (4.0 to 6.9g/day), but contributed considerably less than other categories. In the most recent data (2016-2019), older adults (65y+) had the highest energy-adjusted WG consumption, followed by children 1.5-3y. Individuals with lower incomes, adolescents, and current smokers consumed the least WG. Whole grain intake was associated with generally higher quality diets, specifically consuming more fibre, potassium, calcium, iron, magnesium, fruits/vegetables, pulses/nuts, and oily fish, and consuming less free sugars, total fat, saturated fat, sodium, and red/processed meat (p-trend < 0.001 for all). Despite some dietary improvements in the UK, WG intake appears unchanged from 2008/12 to 2016/19.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coverage of vitamin A supplementation among under-five children in India and its relationship with childhood mortality - insights from multiple rounds of a nationally representative survey from 2005-06 to 2019-21. 印度五岁以下儿童补充维生素A的覆盖率及其与儿童死亡率的关系——来自2005-06年至2019-21年全国代表性多轮调查的见解。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-22 DOI: 10.1017/S0007114525104017

Trishna Bora, Kaustubh Bora

{"title":"Coverage of vitamin A supplementation among under-five children in India and its relationship with childhood mortality - insights from multiple rounds of a nationally representative survey from 2005-06 to 2019-21.","authors":"Trishna Bora, Kaustubh Bora","doi":"10.1017/S0007114525104017","DOIUrl":"https://doi.org/10.1017/S0007114525104017","url":null,"abstract":"We investigated the coverage of childhood vitamin A supplementation (VAS) across India from 2005-06 to 2019-21, and further explored how they related to childhood mortality. Data collected from mothers through standard questionnaires during the latest three rounds of National Family Health Survey (2005-06, 2015-16, and 2019-21) was used. Information on VAS in children aged 9-35 months was available from 2015-16 and 2019-21. Information on VAS among children aged 9-59 months was available from 2005-06 and 2015-16. Childhood VAS coverage was determined nationally and subnationally (viz., individual states, geography, socio-demographic index, and developmental groups). Nearly 40% eligible children aged 9-59 months and 30% eligible children aged 9-35 months missed VAS during recent times. But improvements in VAS coverage were noticed over the years: from 18.6% (2005-06) to 60.5% (2015-16) among children aged 9-59 months; and from 64.5% (2015-16) to 71.2 % (2019-21) among children aged 9-35 months. There were coverage disparities, with Western India documenting the highest and Northeastern India documenting the lowest coverage values. During simple linear regression analysis, childhood mortality between 1-5 years age varied inversely as a function of VAS coverage among children aged 9-59 months, with the association being less pronounced in 2015-16 (β = -0.47) than in 2005-06 (β = -0.40). However, this relationship disappeared when we accounted for potential confounders (viz., childhood immunization and socioeconomic factors) through multivariate analysis, suggesting that the role of VAS in promoting childhood survival may be limited during present times.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-27"},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unfavourable food consumption is exacerbated by low socioeconomic status among children aged 1-5 years in the German nutrition survey KiESEL. 德国KiESEL营养调查显示，1-5岁儿童的低社会经济地位加剧了不利的食物消费。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-22 DOI: 10.1017/S0007114525103991

Leonie Burgard, Clarissa Spiegler, Maik Döring, Andrea Straßburg, Thorsten Heuer, Sara Jansen, Anna-Kristin Brettschneider, Regina Ensenauer, Stefan Storcksdieck Genannt Bonsmann

{"title":"Unfavourable food consumption is exacerbated by low socioeconomic status among children aged 1-5 years in the German nutrition survey KiESEL.","authors":"Leonie Burgard, Clarissa Spiegler, Maik Döring, Andrea Straßburg, Thorsten Heuer, Sara Jansen, Anna-Kristin Brettschneider, Regina Ensenauer, Stefan Storcksdieck Genannt Bonsmann","doi":"10.1017/S0007114525103991","DOIUrl":"https://doi.org/10.1017/S0007114525103991","url":null,"abstract":"Diet in the first years of life is a key determinant of lifelong disease risk and is highly affected by socioeconomic status (SES). However, the specific relation between SES and food consumption in toddlers and preschoolers is poorly understood. This study assesses SES-related differences in food consumption in 1-5-year-olds in Germany using weighed food records (3+1 days) of a subsample of 887 children from the cross-sectional Children's Nutrition Survey to Record Food Consumption (KiESEL) undertaken 2014-2017. Children were categorized as having a low, medium, or high SES depending on parental income, education, and occupation. A two-step generalized linear model corrected for age and sex was applied to assess differences in food consumption, using bootstrapping to address unequal group sizes. Differences between SES groups were found for unfavourable foods (and the subgroups sugar-sweetened beverages and confectionary/desserts), fruit, bread/cereals, and fats/oils (pBoot < 0.05). Mean daily consumption in the low SES-group as compared to the high-SES group was 84 g lower for total fruit, 22 g lower for bread/cereals, and 3 g lower for fats/oils, while being 123 g higher for sugar-sweetened beverages and 158 g higher for unfavourable foods in total (based on bootstrap 95 % confidence intervals). In conclusion, this study suggests a social gradient in the diet of German toddlers and preschoolers, with lower SES linked to lower diet quality. To prevent adverse health trajectories, public health measures to improve early life nutrition should address all children, prioritizing those of lower SES.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vitamin D supplementation for major adverse cardiovascular events: A meta-analysis based on randomized controlled trials. 补充维生素D对主要不良心血管事件的影响：基于随机对照试验的荟萃分析。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-07-21 DOI: 10.1017/S0007114525103954

Xiaoqing Cheng, Zhenghao Chen, Yingying Fang, Qiufeng Zhang, Bangsheng Chen, Wang Xi, Ziqiao Pan, Luyong Guo

{"title":"Effect of vitamin D supplementation for major adverse cardiovascular events: A meta-analysis based on randomized controlled trials.","authors":"Xiaoqing Cheng, Zhenghao Chen, Yingying Fang, Qiufeng Zhang, Bangsheng Chen, Wang Xi, Ziqiao Pan, Luyong Guo","doi":"10.1017/S0007114525103954","DOIUrl":"https://doi.org/10.1017/S0007114525103954","url":null,"abstract":"This meta-analysis assesses the relationship between vitamin D supplementation and incidence of major adverse cardiovascular events (MACEs). Pubmed, Web of science, Ovid, Cochrane Library and Clinical Trials were used to systematically search from their inception until July 2024. Hazard ratios (HR) and 95% confidence intervals (95%CI) were employed to assess the association between vitamin D supplementation and MACEs. This analysis included 5 randomized controlled trials (RCTs). Pooled results showed no significant difference in the incidence of MACEs (HR: 0.96; p=0.77), expanded MACEs (HR: 0.96; p=0.77) between the vitamin D intervention group and the control group. Further, the vitamin D intervention group had a lower incidence of myocardial infarction (MI), but the difference was not statistically significant (HR: 0.88, 95%CI: 0.77-1.01; p=0.061); nevertheless, vitamin D supplementation had no effect on the reduced incidence of stroke (p=0.675) or cardiovascular death (p=0.422). Among males (p=0.109) and females (p=0.468), vitamin D supplementation had no effect on the reduced incidence of MACEs. For participants with a body mass index (BMI)<25 kg/m2, the difference was not statistically significant (p=0.782); notably, the vitamin D intervention group had a lower incidence of MACEs for those with BMI≥25 kg/m2 (HR: 0.91, 95%CI: 0.83-1.00; p=0.055). Vitamin D supplementation did not significantly contribute to the risk reduction of MACEs, stroke and cardiovascular death in the general population, but may be helpful for MI. Notably, effect of vitamin D supplementation for MACEs was influenced by BMI. Overweight/obese people should be advised to take vitamin D to reduce the incidence of MACEs.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-25"},"PeriodicalIF":3.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0