British Journal of Nutrition最新文献

Absorption, accumulation and metabolism of cetoleic acid from dietary herring oil in tissues of diabetic male Zucker Diabetic Sprague Dawley rats.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-14 DOI: 10.1017/S0007114525000236

Eira V Rimmen, Svein Are Mjøs, Eirik Søfteland, Oddrun A Gudbrandsen

{"title":"Absorption, accumulation and metabolism of cetoleic acid from dietary herring oil in tissues of diabetic male Zucker Diabetic Sprague Dawley rats.","authors":"Eira V Rimmen, Svein Are Mjøs, Eirik Søfteland, Oddrun A Gudbrandsen","doi":"10.1017/S0007114525000236","DOIUrl":"https://doi.org/10.1017/S0007114525000236","url":null,"abstract":"Accumulation of exogenous fatty acids such as the long-chain n-11 MUFA cetoleic acid (CA, C22:1n-11) may induce functional changes, through direct effects or by affecting the amounts of other fatty acids through changes in catabolic and anabolic processes including desaturation of fatty acids or by other processes. The primary aim of the present study was to investigate if dietary CA was absorbed and accumulated in a TAG-rich tissue for storage (white adipose tissue), a stable phospholipid-rich tissue (brain), metabolically active tissues (liver and skeletal muscle), or circulating in the blood (blood cells) and metabolised. Secondary aims included to investigate any effects on the levels of EPA and DHA. Eighteen male Zucker Diabetic Sprague Dawley rats were fed diets with herring oil (HERO) containing 0.70 % CA or anchovy oil (ANCO) devoid of CA, or a control diet with soyabean oil for 5 weeks. The HERO and ANCO diets contained 0.35 and 0.37 wt% EPA+DHA, respectively. Data were analysed using one-way ANOVA. CA from dietary HERO was absorbed, and CA and its chain-shortened metabolites were found in blood cells, liver, white adipose tissue and (WAT) and muscle, but n-11 MUFAs were not found in the brain. The concentrations of EPA and DHA were similar in liver lipids (TAG, cholesteryl esters and NEFA) as well as in WAT, muscle and brain from rats fed the HERO or ANCO diets. To conclude, CA was taken up by tissues but did not affect levels of EPA and DHA in this diabetic rat model.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Breakfast Consumption Timing versus Breakfast Omission on Post-Lunch Glycaemia and Insulinaemia in Adolescent Girls: A Randomised Crossover Trial.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-14 DOI: 10.1017/S0007114525000248

Sahar Afeef, Julia K Zakrzewski-Fruer, Alice E Thackray, Laura A Barrett, Keith Tolfrey

{"title":"Impact of Breakfast Consumption Timing versus Breakfast Omission on Post-Lunch Glycaemia and Insulinaemia in Adolescent Girls: A Randomised Crossover Trial.","authors":"Sahar Afeef, Julia K Zakrzewski-Fruer, Alice E Thackray, Laura A Barrett, Keith Tolfrey","doi":"10.1017/S0007114525000248","DOIUrl":"https://doi.org/10.1017/S0007114525000248","url":null,"abstract":"Adolescent girls often skip breakfast due to time constraints and reduced morning appetite. This study examined the acute impact of breakfast consumption timing versus breakfast omission (BO) on glycaemic and insulinaemic responses to lunch in infrequent breakfast-consuming girls. Fifteen girls (13.1±0.8 years) completed three conditions in a randomised crossover design: early-morning breakfast consumption (EM-BC; 8:30), mid-morning breakfast consumption (MM-BC; 10:30), and BO. A standardised lunch was provided at 12:30, followed by a 2-h post-lunch observation period. Blood and expired gas samples were collected periodically. Linear mixed models with Cohen's d effect sizes compared outcomes between conditions. Pre-lunch glucose and insulin incremental area under the curve (iAUC) were higher in the breakfast conditions versus BO (P≤0.009), with no differences between breakfast conditions. MM-BC reduced post-lunch glucose iAUC by 36% and 25% compared with BO and EM-BC, respectively (P<0.001, d=0.92-1.44). A moderate, non-significant 15% reduction in post-lunch glucose iAUC was seen with EM-BC versus BO (P=0.077, d=0.52). These reductions occurred without changes in post-lunch insulinemia (P≥0.323) and were accompanied by increased post-lunch carbohydrate oxidation compared with BO (P≤0.018, d=0.58-0.75); with no differences between EM-BC and MM-BC. MM-BC lowered glycaemic response over the experimental period compared with BO (P=0.033, d=0.98) and EM-BC (P=0.123, d=0.93), with no difference between EM-BC and BO. Compared with BO, both breakfast conditions lowered post-lunch glycaemic responses with mid-morning breakfast eliciting a greater second-meal effect than early-morning breakfast. These findings indicate the breakfast-to-lunch meal interval may be a crucial factor affecting postprandial glycaemia in infrequent breakfast-consuming girls.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-33"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between maternal diet quality in pregnancy and infant feeding practices.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S000711452500025X

Meaghan J Sexton-Dhamu, Katherine M Livingstone, Ewa A Szymlek-Gay, Li Ming Wen, Miaobing Zheng

{"title":"Associations between maternal diet quality in pregnancy and infant feeding practices.","authors":"Meaghan J Sexton-Dhamu, Katherine M Livingstone, Ewa A Szymlek-Gay, Li Ming Wen, Miaobing Zheng","doi":"10.1017/S000711452500025X","DOIUrl":"https://doi.org/10.1017/S000711452500025X","url":null,"abstract":"Postpartum maternal diet quality has been linked with optimal infant feeding practices. However, whether maternal diet quality during pregnancy influences infant feeding practices remains unclear. The present study explored the relationship between maternal diet quality in pregnancy and infant feeding practices in Australian women. A brief 15-item food frequency questionnaire was used to collect maternal dietary data (n = 469). Diet quality was calculated using a modified 2013 Dietary Guideline Index (DGI). Multivariable linear and logistic regressions with adjustment for covariates were used to examine associations between maternal diet quality in pregnancy and infant feeding practices: infant feeding mode, breastfeeding duration and timing of solids introduction. Higher DGI score during pregnancy was associated with higher odds of breastfeeding than formula/mixed feeding (adjusted OR 1.03, 95% CI 1.00, 1.07), longer breastfeeding duration (adjusted β 0.09, 95% CI 0.03, 0.15) and higher odds of breastfeeding for ≥6 months (AOR 1.04, 95% CI 1.02, 1.07) than for <6 months. Associations between maternal DGI score and breastfeeding variables were moderated by maternal country of birth, with significant associations observed in Australian-born mothers only. No association was found between maternal DGI score and timing of solids introduction. Higher maternal diet quality was associated with better infant feeding practices, and the association was moderated by country of birth. Our findings provide evidence to support the initiation of dietary interventions to promote diet quality during pregnancy, particularly among Australian-born women. Further research could explore underlying mechanisms linking maternal diet quality and infant feeding practices.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of vitamin K (phylloquinone and menaquinones 4-10) in various shellfish.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S0007114525000261

Amalie Moxness Reksten, Kari Elin Rød, Inger Aakre, Lise Madsen, Kristin Holvik, Sigrun Henjum, Eystein Oveland, Lisbeth Dahl

{"title":"Quantification of vitamin K (phylloquinone and menaquinones 4-10) in various shellfish.","authors":"Amalie Moxness Reksten, Kari Elin Rød, Inger Aakre, Lise Madsen, Kristin Holvik, Sigrun Henjum, Eystein Oveland, Lisbeth Dahl","doi":"10.1017/S0007114525000261","DOIUrl":"https://doi.org/10.1017/S0007114525000261","url":null,"abstract":"Vitamin K exists naturally in foods as phylloquinone (vitamin K1, PK) and as a range of menaquinones (vitamin K2, MKs). There is scarce information on the occurrence and distribution of PK and MKs in dietary sources, particularly in seafood. This study aimed to comprehensively analyse the contents of vitamin K1, dihydro-K1, and MK-4 to MK-10 in various species, tissue types, and processing degrees of shellfish. Additionally, seasonal differences in the vitamin K content of blue mussels (Mytilus edulis) were explored. Most shellfish products had low contents of total vitamin K (<10 µg/100 g). The highest content of total vitamin K was found in the hepatopancreas of snow crab (170 µg/100 g), the brown meat of brown crab (35 µg/100 g), pre-packaged blue mussels (20 µg/100 g), stuffed brown crab shells (15 µg/100 g), and blue mussels in brine (12 µg/100 g). In general, the hepatopancreas of crustaceans contained considerably higher contents of vitamin K than their white meat counterparts. MKs contributed most to total vitamin K contents, whereas most shellfish products contained low contents of PK, thus making only a minor contribution to the adequate intake (AI) established for adults. No statistically significant differences were observed in PK and MK contents of blue mussels sampled during spring versus late summer (p < 0.005). Nevertheless, a non-significant trend of increasing vitamin K content was observed towards the autumn months. This study presents novel vitamin K data for shellfish, an unexplored food group, and adds to the scarce vitamin K composition data worldwide.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-34"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of moderate wine consumption on the activity of enzymes involved in Platelet Activating Factor metabolism and thrombotic biomarkers: A randomized, single-blind, parallel, clinical study in coronary heart disease men patients.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S0007114525000273

Elizabeth Fragopoulou, Chrysa Argyrou, Eleni Matalliotaki, Christos Pafilas, Maria Detopoulou, Smaragdi Antonopoulou, Genovefa Kolovou, Petros Kalogeropoulos

{"title":"Effect of moderate wine consumption on the activity of enzymes involved in Platelet Activating Factor metabolism and thrombotic biomarkers: A randomized, single-blind, parallel, clinical study in coronary heart disease men patients.","authors":"Elizabeth Fragopoulou, Chrysa Argyrou, Eleni Matalliotaki, Christos Pafilas, Maria Detopoulou, Smaragdi Antonopoulou, Genovefa Kolovou, Petros Kalogeropoulos","doi":"10.1017/S0007114525000273","DOIUrl":"https://doi.org/10.1017/S0007114525000273","url":null,"abstract":"A randomized parallel intervention study was conducted with male patients diagnosed with coronary heart disease. Participants were assigned to three groups: Group A abstained from alcohol (n=20), Group B consumed red wine (n=21) and Group C (n=16) consumed an alcoholic beverage without wine micro-constituents. Biological samples were collected at baseline, 4 and 8 weeks. Enzyme activities of acetyl-CoA:lyso-PAF acetyltransferase (LysoPAF-AT), CDP-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT), PAF-acetylhydrolase (PAF-AH) in leukocyte homogenates, serum lipoprotein associated phospholipase-A2 (LpPLA2) and plasma markers of thrombosis were measured. PAF-, adenosine diphosphate (ADP)-, and collagen- induced platelet aggregation was measured in human platelet rich plasma.Red wine consumption led to 15.3% reduction in LysoPAF-AT activity at 4 weeks (p=0.008) compared to baseline and Group A (p=0.01). PAF-CPT activity was reduced by 11.1% at 8 weeks (p=0.04) compared to baseline, and by 24.9% compared to Group C (p=0.02). PAF-AH activity was reduced by 36.2% at 8 weeks compared to baseline (p=0.001) and compared to Group A (p<0.000) and Group C (p=0.009). Fibrinogen levels in Group B reduced by 6-9% at 4 (p=0.04) and 8 weeks (p=0.01) compared to baseline while d-dimer in Group C increased by 16.1% at 8 weeks (p=0.005) compared to baseline. Platelet aggregation against PAF and collagen was reduced in Group B (82.6% and 35.4%, respectively), and in Group C (158.4% and 37.1%, respectively) compared to baseline and Group A (p<0.05).In conclusion, moderate wine consumption improved the activity of PAF-metabolism enzymes regardless of ethanol and reduced platelet aggregation probably through mechanisms different from those of ethanol.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-28"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Understanding of Dietary Total Antioxidant Capacity and Skeletal Muscle Mass: Addressing Key Limitations and Future Directions.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S0007114525000285

Zhongxing Liu, Mengzhe Tian, Lincheng Duan

引用次数: 0

Response to the Comment on "Effects of Black Chokeberry (Aronia melanocarpa) Supplementation on Oxidative Stress, Inflammation, and Gut Microbiota".

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S0007114525000145

Sabina Kaczmarczyk, Hanna Dziewiecka

引用次数: 0

Prevalence and determinants of wasting and overweight in Brazilian children between 6- 59 months: Brazilian National Survey on Child Nutrition (ENANI-2019).

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S0007114525000297

D R Farias, L A Anjos, T L Berti, N H A Santos, P G Andrade, M B de Freitas, J L da Costa, N Oliveira, E M A Lacerda, L B V Carneiro, R M Schincaglia, P Normando, I R R de Castro, G Kac

{"title":"Prevalence and determinants of wasting and overweight in Brazilian children between 6- 59 months: Brazilian National Survey on Child Nutrition (ENANI-2019).","authors":"D R Farias, L A Anjos, T L Berti, N H A Santos, P G Andrade, M B de Freitas, J L da Costa, N Oliveira, E M A Lacerda, L B V Carneiro, R M Schincaglia, P Normando, I R R de Castro, G Kac","doi":"10.1017/S0007114525000297","DOIUrl":"https://doi.org/10.1017/S0007114525000297","url":null,"abstract":"Understanding the determinants of malnutrition is pivotal for public health interventions. This study aimed to identify socio-economic, demographic, dietary, and maternal determinants of wasting and overweight among Brazilian children between 6-59 months. Data from the Brazilian National Survey on Child Nutrition were analyzed (n=11,789). Children's weight-for height Z scores were calculated according to the WHO growth standard and classified as wasting (Z < -2), normal weight (-2 ≤ Z ≤1), overweight risk (1 < Z ≤ 2), and overweight (Z > 2). Socio-economic, demographic, dietary, and maternal covariables were considered. Adjusted multinomial logistic regression (odds ratio (OR) and 95% confidence interval (95% CI) was employed. The prevalence of overweight and wasting was 9.5% and 2.6%, respectively. In the adjusted model, younger age (6-23 months: OR: 1.7; 95%CI: 1.3; 2.2), consumption of ≥ 5 ultra-processed food groups (OR: 1.8; 95%CI: 1.1; 3.1), maternal underweight (OR: 0.4; 95%CI: 0.2; 0.9), overweight (OR: 1.5; 95%CI: 1.2; 1.9) and mild food insecurity (OR: 0.8; 95%CI: 0.6; 1.0) were associated with child overweight. The Brazilian Northeast (OR: 4.9; 95%CI: 2.1; 11.3), Southeast (OR: 7.1; 95%CI: 3.0; 16.6), South (OR: 4.7; 95%CI: 1.8; 12.1), Midwest regions (OR: 2.7; 95%CI: 1.2; 6.2) and maternal underweight (OR: 5.4; 95%CI: 2.7; 10.7) were associated with wasting. Overweight in Brazil is prevalent among children between 6-59 months, while wasting is not a major public health problem. The main determinants of these Brazilian children's nutritional status were age, ultra-processed food consumption, and maternal nutritional status.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum insulin-like growth factor 1 in young children with moderate acute malnutrition: secondary analysis of a randomized trial in Burkina Faso.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-13 DOI: 10.1017/S0007114525000212

Thora W Helt, Bernardette Cichon, Christian Fabiansen, Ann-Sophie Iuel-Brockdorff, Charles W Yaméogo, Christian Ritz, André Briend, Kim F Michaelsen, Suzanne Filteau, Henrik Friis, Vibeke B Christensen, Benedikte Grenov

{"title":"Serum insulin-like growth factor 1 in young children with moderate acute malnutrition: secondary analysis of a randomized trial in Burkina Faso.","authors":"Thora W Helt, Bernardette Cichon, Christian Fabiansen, Ann-Sophie Iuel-Brockdorff, Charles W Yaméogo, Christian Ritz, André Briend, Kim F Michaelsen, Suzanne Filteau, Henrik Friis, Vibeke B Christensen, Benedikte Grenov","doi":"10.1017/S0007114525000212","DOIUrl":"https://doi.org/10.1017/S0007114525000212","url":null,"abstract":"Insulin-like growth factor 1 (IGF-1) is an important growth factor in childhood. We aimed to investigate the impact of food supplements for treatment of moderate acute malnutrition (MAM) on serum IGF-1 (sIGF-1). Secondary analysis of a randomized 2×2×3 factorial nutrition trial was performed. Children aged 6-23 months with MAM received 2093 kJ/day as lipid-based nutrient supplement (LNS) or corn-soy blend (CSB), containing either dehulled soy or soy isolate and different quantities of dried skimmed milk (0%, 20% or 50% of total protein) for 12 weeks. The trial was double-blind with regard to soy and milk, but not to matrix (LNS vs. CSB). sIGF-1 was measured at inclusion and after 12 weeks supplementation. Of 1609 children enrolled, 1455 (90%) had sIGF-1 measured at both time points. During supplementation sIGF-1 increased 6.7 (95%CI 6.1; 7.3) ng/ml compared with an expected age-dependent decrease of 0.3 (95%CI 0.2; 0.4) ng/ml. Children who received LNS vs. CSB had lower increase in sIGF-1 (-8%, 95%CI -12; -3). The effect of LNS was partly attenuated when sIGF-1 was corrected for inflammation. Children who received soy isolate compared with dehulled soy had higher increase in sIGF-1 (6%, 95%CI 1; 12). Milk content did not affect sIGF-1. Overall, sIGF-1 increased during supplementation. The lower increase with LNS vs. CSB was only partly explained by increased inflammation with LNS, and needs further investigation. Isolate vs. dehulled soy led to a higher increase which may be due to antinutrients in dehulled soy.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-22"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary glycemic index and insulin index in association with incident type 2 diabetes mellitus in adults.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-10 DOI: 10.1017/S0007114524002307

Peyman Sarsangi, Mohammad Mohammadi, Azadeh Nadjarzadeh, Amin Salehi-Abargouei, Ahmad Esmaillzadeh, Masoud Mirzaei

{"title":"Dietary glycemic index and insulin index in association with incident type 2 diabetes mellitus in adults.","authors":"Peyman Sarsangi, Mohammad Mohammadi, Azadeh Nadjarzadeh, Amin Salehi-Abargouei, Ahmad Esmaillzadeh, Masoud Mirzaei","doi":"10.1017/S0007114524002307","DOIUrl":"https://doi.org/10.1017/S0007114524002307","url":null,"abstract":"There is a lack of information from Middle Eastern countries regarding diet-disease associations. We examined dietary glycemic and insulinemic potential in relation to risk of incident diabetes among a large group of Iranian adults. The present study was carried out using data from Yazd Health Study (YaHS)-Taghzieh Mardom Yazd (TAMYZ), a prospective cohort study on adults aged 20 to 70 years in Yazd Greater Area, Iran. This study was initiated in 2014-2016 (baseline examination) and data are collected prospectively at one 5-year intervals. Data on demographic characteristics, dietary intakes, and potential confounders were gathered by interview. During the follow-up phase of the study, diabetes incidence was confirmed by laboratory tests and physician diagnoses. This study included a total of 6178 participants in the cross-sectional analysis and 5105 subjects in the prospective phase. Examining the cross-sectional phase, we failed to find any significant association between dietary glycemic index (GI) and glycemic load (GL) as well as dietary insulin index (DII) or dietary insulin load (DIL) and prevalence of diabetes. No significant relationship was also seen between DII/DIL and risk of T2DM in the prospective phase; however, in the stratified analysis by BMI status, there was an inverse significant association between DII and risk of T2DM (HR for T3 vs. T1: 0.19; 95%CI: 0.04, 0.92; P=0.03) in non-obese (BMI≥25 kg/m2) and overweight (BMI<25 kg/m2)participants. No significant association was found between dietary GI/ dietary GL/ DII/ or DIL with risk of T2DM. More research, particularly with a longer follow-up duration, is needed to confirm these findings.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-32"},"PeriodicalIF":3.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0