British Journal of Nutrition最新文献

{"title":"Advances in methods for characterizing dietary patterns: A scoping review.","authors":"Joy M Hutchinson, Amanda Raffoul, Alexandra Pepetone, Lesley Andrade, Tabitha E Williams, Sarah A McNaughton, Rebecca M Leech, Jill Reedy, Marissa M Shams-White, Jennifer E Vena, Kevin W Dodd, Lisa M Bodnar, Benoît Lamarche, Michael P Wallace, Megan Deitchler, Sanaa Hussain, Sharon I Kirkpatrick","doi":"10.1017/S0007114524002587","DOIUrl":"10.1017/S0007114524002587","url":null,"abstract":"<p><p>There is a growing focus on understanding the complexity of dietary patterns and how they relate to health and other factors. Approaches that have not traditionally been applied to characterize dietary patterns, such as latent class analysis and machine learning algorithms, may offer opportunities to characterize dietary patterns in greater depth than previously considered. However, there has not been a formal examination of how this wide range of approaches has been applied to characterize dietary patterns. This scoping review synthesized literature from 2005-2022 applying methods not traditionally used to characterize dietary patterns, referred to as novel methods. MEDLINE, CINAHL, and Scopus were searched using keywords including latent class analysis, machine learning, and least absolute shrinkage and selection operator. Of 5274 records identified, 24 met the inclusion criteria. Twelve of 24 articles were published since 2020. Studies were conducted across 17 countries. Nine studies used approaches with applications in machine learning, such as classification models, neural networks, and probabilistic graphical models, to identify dietary patterns. The remaining studies applied methods such as latent class analysis, mutual information, and treelet transform. Fourteen studies assessed associations between dietary patterns characterized using novel methods and health outcomes, including cancer, cardiovascular disease, and asthma. There was wide variation in the methods applied to characterize dietary patterns and in how these methods were described. The extension of reporting guidelines and quality appraisal tools relevant to nutrition research to consider specific features of novel methods may facilitate consistent reporting and enable synthesis to inform policies and programs.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-47"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of soy consumption on serum adiponectin and leptin levels: An umbrella review of meta-analyses based on randomized controlled trials.","authors":"Harikumar Pallathadka, Enwa Felix Oghenemaro, Bahaa Ibrahim Saeed, N Esanmurodova, Roopashree R, Deepak Nathiya, Parjinder Kaur, M Ravi Kumar, Muthena Kariem, Naher H S","doi":"10.1017/S0007114525000467","DOIUrl":"https://doi.org/10.1017/S0007114525000467","url":null,"abstract":"<p><p>The therapeutic effects of soy consumption on adipokine concentrations have yielded inconsistent results in previous meta-analyses. This umbrella meta-analysis aims to investigate the impact of soy and its isoflavones on serum adiponectin and leptin levels in adults. We searched the Cochrane Central, Web of Science, PubMed, and Scopus databases until October 10, 2024. The articles were restricted to those written in English. We included meta-analysis studies that evaluated the effects of soy and its isoflavones on levels of adiponectin and leptin and reported effect sizes (ES) and corresponding confidence intervals (CI). Two independent reviewers screened all articles based on eligibility criteria and extracted the required data from the included meta-analyses. The meta-analysis was performed using a random-effects model in STATA software. Six meta-analyses of randomized controlled trials meeting the inclusion criteria were included in the current umbrella meta-analysis. The findings indicated that soy and its isoflavones did not have a significant effect on adiponectin (ES= 0.10; 95% CI: -0.22, 0.41; P=0.55; <i>I</i> ^<i>2</i> = 51.8%) and leptin (ES= -0.37; 95% CI: -1.35, 0.61; P=0.46; <i>I</i> ^<i>2</i> = 71.2%) concentrations. Subgroup analysis based on participants' mean age, total sample size, and duration was conducted. Results showed that the effect is not statistically significant in any of the subgroups. In conclusion, soy and its isoflavones could not improve the adipokines mentioned above. However, further high-quality research in different countries is required to substantiate these findings.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet's total antioxidant capacity and women's health: systematic review and meta-analysis.","authors":"Tauane A Dutra, Marilene B T Fragoso, Thiago M Wanderley, Alexandra R Bezerra, Nassib B Bueno, Alane C M de Oliveira","doi":"10.1017/S0007114525000443","DOIUrl":"https://doi.org/10.1017/S0007114525000443","url":null,"abstract":"<p><p>The primary causes of female mortality often involve diseases related to oxidative stress. Dietary total antioxidant capacity (TAC) evaluates its antioxidant content and potential health effects. This study, registered with PROSPERO (ID: CRD42024427784), explores the association between dietary TAC and women's health outcomes, including endocrine conditions with gynecological implications, obstetric outcomes, gynecological conditions, and oncological diseases related to the female reproductive system. We conducted a systematic search in MEDLINE (via PubMed), EMBASE, LILACS, and CINAHL for observational studies published up to February 2024 that explored the relationship between dietary TAC and these health conditions. Data were analyzed using RevMan 5.4 software. Nineteen studies met the eligibility criteria (sample sizes: 64 to 3,209 women) and examined various conditions, including neoplasms (breast, endometrial, and ovarian), bacterial vaginosis, menopause, polycystic ovary syndrome (PCOS), pre-eclampsia (PE), gestational diabetes mellitus (GDM), miscarriage, infertility, and inflammation and oxidative stress markers. The meta-analysis identified a significant association between dietary total antioxidant capacity (TAC), measured in vitamin C equivalents, and breast cancer, revealing that women with the disease had a lower dietary TAC due to reduced antioxidant intake. Mixed results were found for endometrial cancer, while higher TAC levels were associated with a lower risk of PCOS and infertility. Among postmenopausal women, higher TAC correlated with fewer symptoms such as sleep issues and anxiety. In gestational conditions, higher dietary TAC was linked to a lower risk of miscarriage, GDM, and PE. Twelve of the nineteen studies demonstrated significant associations between dietary TAC and the outcomes of interest.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-29"},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of the dietary advanced glycation end products with functional gastrointestinal disorders: The Isfahan functional disorders (ISFUN) cohort study.","authors":"Fahimeh Haghighatdoost, Awat Feizi, Tiffany K Gill, Parisa Hajihashemi, Hassan Shahoon, Alireza Ani, Hamidreza Roohafza, Peyman Adibi","doi":"10.1017/S0007114525000388","DOIUrl":"https://doi.org/10.1017/S0007114525000388","url":null,"abstract":"<p><p>High intake of dietary advanced glycation end products (AGEs), could induce oxidative stress, inflammation, and the gut microbiota dysbiosis, processes that play a major role in the development of functional gastrointestinal disorders (FGIDs). There is limited data on the association between AGEs intake and FGIDs. Therefore, the current study aimed to examine the association of AGEs with FGIDs in Iranian adults. In a cross-sectional analysis under the framework of the Isfahan functional disorders (ISFUN) study, data on 1892 Iranian apparently healthy adults, aged 18 to 65 years were examined. Participants' dietary intakes were collected using a validated dish-based, 106- item food frequency questionnaire. Dietary AGEs content of 72 food items were measured for all participants. FGIDs was assessed using ROME IV criteria. In total, 38% of subjects had one of the most prevalent upper or lower FGIDs. The mean of AGEs intake was 14690.10±8797.25 (kU/gr). In the fully adjusted model, being in the highest versus lowest tertile of AGEs intake was associated with increased odds of FGIDs (OR= 1.78; 95% CI: 1.01, 3.36). In stratified analysis by sex, males in the highest tertile of AGEs intake showed higher odds of FGIDs than those in the lowest tertile (OR= 2.15; 95% CI: 1.04, 4.45). However, in females, the AGEs intake was not significantly associated with the risk of FGIDs in the fully adjusted model. Higher AGEs intake was significantly associated with increased risk of FGIDs, particularly in men. Further prospective studies are warranted to confirm these findings.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-22"},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional associations between healthy and unhealthy plant-based diets and metabolic syndrome in three distinct French populations, a meta-analysis.","authors":"Clémentine Prioux, Sandra Wagner, Léopold K Fézeu, Valérie Deschamps, Charlotte Verdot, Julia Baudry, Mathilde Touvier, Serge Herberg, Julie-Anne Nazare, Axelle Hoge, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd, Sopio Tatulashvili, Emmanuelle Kesse-Guyot, Benjamin Allès","doi":"10.1017/S0007114525000376","DOIUrl":"https://doi.org/10.1017/S0007114525000376","url":null,"abstract":"<p><p>Prior studies have shown that plant-based diets are associated with lower cardiovascular risk. However, these diets encompass a large diversity of foods with contrasted nutritional quality that may differentially impact health. We aimed to investigate the pooled cross-sectional association between metabolic syndrome (MetS), its components, and healthy and unhealthy plant-based diet indices (hPDI and uPDI), using data from two French cohorts and one representative study from the French population. This study included 16,358 participants from the NutriNet-Santé study, 1,769 participants from the Esteban study and 1,565 participants from the STANISLAS study who underwent a clinical visit. The MetS was defined according to the International Diabetes Federation definition. The associations between these plant-based diet indices and MetS were estimated by multivariable Poisson and logistic regression models, stratified by gender. Meta-analysis enabled the computation of a pooled Prevalence Ratio. A higher contribution of healthy plant foods (higher hPDI) was associated with a lower probability of having MetS (PR_men: 0.85; 95% CI: 0.75-0.94, PR_women: 0.72; 95% CI: 0.67-0.77), elevated waist circumferences and elevated blood pressure. In women, a higher hPDI was associated with a lower probability of having elevated triglycerides, low HDL-cholesterolemia and hyperglycemia; and a higher contribution of unhealthy plant foods was associated with a higher prevalence of MetS (PR_women: 1.13; 95% CI: 1.01-1.26) and elevated triglycerides. A greater contribution of healthy plant floods was associated with protective effects on metabolic syndrome, especially in women. Gender differences should be further investigated in relation to the current sustainable nutrition transition.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-48"},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of cognitive task scores with energy intake measurement error from technology-assisted 24 hr recalls.","authors":"Clare Whitton, Barbara A Mullan, Satvinder S Dhaliwal, Richard Norman, Carol J Boushey, Clare E Collins, Megan E Rollo, Deborah A Kerr","doi":"10.1017/S000711452500042X","DOIUrl":"https://doi.org/10.1017/S000711452500042X","url":null,"abstract":"<p><p>Measurement error undermines the accuracy of dietary intake data. The 24-hour dietary recall (24HR) is the standard data collection method in nutrition surveillance. Several neurocognitive processes underpin the act of recall, and individuals differ in their performance of these processes. This study aimed to investigate whether variation in neurocognitive processes, measured using four cognitive tasks, was associated with variation in measurement error of 24HRs. Participants (n 139) completed the Trail Making Test, the Wisconsin Card Sorting Test, the Visual Digit Span, and the Vividness of Visual Imagery questionnaire. During a controlled feeding study, participants completed three technology-assisted 24HR; the Automated Self-Administered Dietary Assessment Tool (ASA24), Intake24, and an Interviewer-Administered Image-Assisted 24HR (IA-24HR) one week apart. Percentage error between reported and true energy intakes was calculated. Using linear regression, the association between cognitive task scores and absolute percentage error in estimated energy intake was assessed. Longer time spent completing the Trail Making Test, an indicator of visual attention and executive functioning, was associated with greater error in energy intake estimation using ASA24 (B 0.13, 95% CI 0.04, 0.21) and Intake24 (B 0.10, 95% CI 0.02, 0.19). Regression models explained 13.6% (ASA24) and 15.8% (Intake24) of the variance in energy estimation error. No cognitive task scores were associated with error using IA-24HR. This study demonstrates that variation between individuals in neurocognitive processes explains some of the variation in 24HR error. Further investigation into the role of neurocognitive processes in 24HR and their role in the reliability of dietary intake data is warranted.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-26"},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient intake variability and number of days needed to estimate usual intake in children and adolescents with autism spectrum disorder.","authors":"Eduarda Silva, Laura Hoffmann, Kamila Castro, Eliseu Verly Junior, Sandra Valle, Juliana Vaz","doi":"10.1017/S0007114525000200","DOIUrl":"https://doi.org/10.1017/S0007114525000200","url":null,"abstract":"<p><p>Children and adolescents diagnosed with autism spectrum disorder (ASD) present feeding problems that may influence food acceptance and refusal. However, data regarding dietary intake variability in this population are either not available in the literature or not well-known. This cross-sectional study aimed to identify the within-person and between-person variability, and the number of days needed for a 24-hour recall (24HR) to estimate the usual intake of children and adolescents with ASD. Data were collected from 284 patients assisted at a public neuropediatric health service in the city of Pelotas, Southern Brazil. Food consumption was assessed using three non-consecutive 24HR. Within-person (S²_w) and between-person (S²_b) variances, the variance ratio (VR), and the distribution of energy, macronutrients, and micronutrients were obtained using the Multiple Source Method® (version 1.0.1). The number of days of 24HR needed was calculated for correlation coefficients of 0.7, 0.8, and 0.9. For most nutrients, S²_w was greater than S²_b, resulting in RV>1, except for age-group analyses where children up to 5 years old showed VR<1. Two to three days of 24HR were estimated for most nutrients, considering a correlation coefficient of 0.8. Differences were observed according to sex and age group, with adolescents requiring more days of 24HR. These findings indicate the need to assess dietary variability among individuals with ASD according to the characteristics of this investigated population.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-24"},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Association Between the Mediterranean, DASH, and MIND Dietary Patterns, Structural Connectivity, and Cognitive Function.","authors":"Lizanne Arnoldy, Sarah Gauci, Lauren M Young, Helen Macpherson, Oren Civier, Andrew Scholey, Andrew Pipingas, David J White","doi":"10.1017/S0007114525000406","DOIUrl":"https://doi.org/10.1017/S0007114525000406","url":null,"abstract":"<p><p>The rising incidence of neurodegenerative diseases in an ageing global population has shifted research focus toward modifiable risk factors, such as diet. Despite potential links between dietary patterns and brain health, inconsistencies in neuroimaging outcomes underscore a gap in understanding how diet impacts brain ageing. This study explores the relationship between three dietary patterns-Mediterranean (MeDi), Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND)-and cognitive outcomes as well as brain connectivity. The study aimed to assess the association of these diets with brain structure and cognitive function, involving a middle-aged healthy group and an older cohort with subjective cognitive decline (SCD). The study included cognitive assessments and diffusion-weighted MRI data to analyse white matter microstructural integrity. Participants comprised 55 older individuals with SCD (54.5% female, mean age = 64) and 52 healthy middle-aged individuals (48.1% female, mean age = 53). Age inversely correlated with certain cognitive functions and global brain metrics, across both cohorts. Adherence to the MeDi, DASH, and MIND diets showed no significant cognitive or global brain metric improvements after adjusting for covariates (age, education, BMI). Network-based statistics (NBS) analysis revealed differences in brain subnetworks based on DASH diet adherence levels in the SCD cohort. In the healthy cohort, lower white matter connectivity was associated with reduced adherence to MIND and DASH diets. Ultimately, the study found no strong evidence connecting dietary patterns to cognitive or brain connectivity outcomes. Future research should focus on longitudinal studies and refine dietary assessments.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-49"},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased costs associated with greater adherence to the EAT-Lancet Commission reference diet in the province of Québec: The PREDISE study.","authors":"Gabrielle Rochefort, Marie-Claude Paquette, Julie Robitaille, Simone Lemieux, Véronique Provencher, Benoît Lamarche","doi":"10.1017/S0007114525000364","DOIUrl":"https://doi.org/10.1017/S0007114525000364","url":null,"abstract":"<p><p>The diet proposed by the EAT-Lancet Commission has faced criticism concerning its affordability. This study aimed to investigate the cost associated with a greater alignment to the EAT-Lancet reference diet in the province of Québec, Canada. The dietary habits of 1147 French-speaking adults were assessed using repeated Wed-based 24-hour recall data collected between 2015 and 2017 in the cross-sectional PRÉDicteurs Individuels, Sociaux et Environnementaux (PREDISE) study. Diet costs were calculated using a Nielsen food price database. Usual dietary intakes and diet costs were estimated using the National Cancer Institute's multivariate Markov Chain Monte Carlo method. Adherence to the EAT-Lancet diet was assessed using the EAT-Lancet dietary index (EAT-I). Associations between diet costs and EAT-I scores were evaluated using linear regression models with restricted cubic splines. After adjustment for energy intake, a higher EAT-I score (75th vs. 25th percentiles) was associated with a 1.0 $CAD increase in daily diet costs (95%CI, 0.7 to 1.3). This increase in diet costs was mostly driven by the following component scores of the EAT-I (75th vs. 25th percentiles, higher scores reflecting greater adherence): Vegetables (1.6$CAD/day, 95%CI: 1.2, 2.1), Free sugars (1.6$CAD/day, 95%CI: 1.3, 1.9), Fish and plant-based proteins (1.4$CAD/day, 95%CI: 1.0, 1.8), Fruits (0.9$CAD/day, 95%CI: 0.4, 1.3), and Whole-grains (0.4$CAD/day, 95%CI: 0.0, 0.8). Inversely, greater scores for the Poultry and eggs component were associated with reduced diet costs (-1.2$CAD/day, 95%CI: -1.7, -0.7). This study suggests that adhering to the EAT-Lancet diet may be associated with an increase in diet costs in the province of Québec.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-21"},"PeriodicalIF":3.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial Effects of Okra (<i>Abelmoschus esculentus L.</i>) Consumption on Anthropometric Measures, Blood Pressure, Glycemic Control, Lipid Profile, and Liver Function Tests in Randomized Controlled Trials: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis.","authors":"Ali Jafari, Helia Mardani, Bahare Parsi Nezhad, Alireza Alaghi, Amirhossein Sahebkar","doi":"10.1017/S0007114525000303","DOIUrl":"https://doi.org/10.1017/S0007114525000303","url":null,"abstract":"<p><p>This review aimed to assess the impact of okra (<i>Abelmoschus esculentus L.</i>) consumption on cardiovascular disease risk factors. Relevant studies were identified through electronic searches of databases including PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to January 2025. Twelve trials involving 770 participants with interventions ranging from 2 to 12 weeks and doses varying from 125 to 40,000 mg/day, were included. Okra supplementation significantly reduced body mass index (BMI) (Standardized Mean Difference [SMD] = -0.70; 95% Confidence Interval [CI]: -1.23, -0.16; P = 0.011), fat mass (FM) (SMD = -0.74; 95% CI: -1.13, -0.36; P < 0.001), hip circumference (HC) (SMD = -0.85; 95% CI: -1.41, -0.28; P = 0.003), weight (SMD = -0.77; 95% CI: -1.42, -0.11; P = 0.022), fasting insulin (SMD = -0.35; 95% CI: -0.63, -0.07; P = 0.013), fasting plasma glucose (FPG) (SMD = -1.07; 95% CI: -1.75, -0.38; P = 0.002), hemoglobin A1c (HbA1c) (SMD = -0.38; 95% CI: -0.71, -0.05; P = 0.023), homeostatic model assessment of insulin resistance (HOMA-IR) (SMD = -0.56; 95% CI: -0.84, -0.29; P < 0.001), low-density lipoprotein cholesterol (LDL-C) (SMD = -0.32; 95% CI: -0.52, -0.11; P = 0.003), total cholesterol (TC) (SMD = -0.45; 95% CI: -0.74, -0.16; P = 0.003), and aspartate aminotransferase (AST) (SMD = -0.45; 95% CI: -0.73, -0.17; P = 0.002). Okra supplementation demonstrated significant benefits in improving anthropometric measures, glycemic control, lipid profiles, and liver function tests, suggesting its potential as an adjunct therapy for improving cardiovascular disease risk factors.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-87"},"PeriodicalIF":3.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}