British Journal of Nutrition最新文献_第2页

Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-10 DOI: 10.1017/S0007114525000194

Isabelle Durocher, Daniel S Grant, Marc R Bomhof

{"title":"Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.","authors":"Isabelle Durocher, Daniel S Grant, Marc R Bomhof","doi":"10.1017/S0007114525000194","DOIUrl":"https://doi.org/10.1017/S0007114525000194","url":null,"abstract":"The influence of appetite and energy intake on energy compensation in response to chronic exercise remains poorly understood. This study examined the temporal impact of habitual exercise on energy intake and the homeostatic appetite regulators that influence energy compensation. Twelve-week-old male Sprague Dawley rats (n=30) fed an AIN-93M diet were randomised into 1 of 3 groups: 1) sedentary control (SED); 2) voluntary wheel exercise (EX); and 3) sedentary, weight-matched to aerobic exercise (SED-WM) for 8 weeks. Measures of energy intake, body weight, and adiposity were assessed. Appetite-regulating hormones acyl-ghrelin, active GLP-1, leptin, and insulin were measured in response to an oral glucose tolerance test. Rats with running wheels completed an average of 192kms over 8 weeks. While energy intake was initially reduced in EX, energy intake gradually increased with exercise training after week 1 (P<0.05). Body weight was lower in EX relative to SED from weeks 3-5, but did not differ at the end of the study. Fat mass and long-term satiety hormones leptin and insulin were lower in EX (P<0.05). No differences were observed in concentrations of the satiety hormone active GLP-1 or the orexigenic hormone acyl-ghrelin. Short-term homeostatic regulators of appetite do not appear to be altered with exercise training. The reduction in adiposity and associated decrease in tonic satiety hormones leptin and insulin are likely contributors to the coupling of energy expenditure with energy intake over time with voluntary exercise.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-29"},"PeriodicalIF":3.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Probiotic Supplementation on Intestinal Flora, Brain-Gut Peptides, and Clinical Outcomes in Children with Anorexia Nervosa.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-07 DOI: 10.1017/S0007114525000169

Xiaoyan Lu, Yali Liu, Longxia Hao, Junqiong Li, Linjuan Hua

{"title":"Effects of Probiotic Supplementation on Intestinal Flora, Brain-Gut Peptides, and Clinical Outcomes in Children with Anorexia Nervosa.","authors":"Xiaoyan Lu, Yali Liu, Longxia Hao, Junqiong Li, Linjuan Hua","doi":"10.1017/S0007114525000169","DOIUrl":"https://doi.org/10.1017/S0007114525000169","url":null,"abstract":"To assess the therapeutic effects of probiotic oral therapy in pediatric patients with anorexia nervosa and to investigate its impact on intestinal flora composition, brain-gut peptide levels, and overall clinical outcomes. A retrospective study was conducted involving 100 children diagnosed with anorexia nervosa at Xingtang County People's Hospital between January 2023 and June 2024. Patients were divided into two groups: a control group (n=50) receiving zinc gluconate oral solution alone and an observation group (n=50) receiving zinc gluconate plus probiotics. Outcome measures included intestinal flora analysis, brain-gut peptide levels (SS, NO), clinical efficacy, serum trace element levels (calcium, zinc, iron), and prognosis, including recurrence rates six months post-treatment. Baseline characteristics were similar between the two groups (P>0.05). After treatment, the observation group showed significantly higher levels of Bifidobacterium and Lactobacillus and lower levels of Enterobacter compared to the control group (P<0.05). Additionally, the observation group had lower levels of SS and NO (P<0.05), indicating improved brain-gut communication. Clinical efficacy was significantly higher in the observation group (P<0.05), with improved serum trace element levels (P<0.05 for calcium, zinc, and iron). Furthermore, the recurrence rate six months post-treatment was significantly lower in the observation group compared to the control group (P<0.05). Probiotic supplementation in children with anorexia nervosa effectively modulates intestinal flora, improves brain-gut peptide levels, and enhances clinical outcomes.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Children's adherence to a healthy and environmentally sustainable dietary pattern based on the EAT-Lancet recommendations: the role of the family environment.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-06 DOI: 10.1017/S0007114525000157

Beatriz Teixeira, Cláudia Afonso, Andreia Oliveira

{"title":"Children's adherence to a healthy and environmentally sustainable dietary pattern based on the EAT-Lancet recommendations: the role of the family environment.","authors":"Beatriz Teixeira, Cláudia Afonso, Andreia Oliveira","doi":"10.1017/S0007114525000157","DOIUrl":"https://doi.org/10.1017/S0007114525000157","url":null,"abstract":"This study aimed to investigate the association between family characteristics and adherence to the EAT-Lancet dietary recommendations in 7-year-old children. This is a prospective birth cohort study with 2062 children from Generation XXI (Porto, Portugal), who provided 3-day food diaries at age 7, used to assess habitual food consumption. At the age of 4, maternal diet was assessed using a Food Frequency Questionnaire, and a diet quality score was calculated (higher scores indicating a better maternal diet), and parental-child feeding practices were assessed with the Child-Feeding Questionnaire. Adherence to the EAT-Lancet recommendations was evaluated using the World Index for Sustainability and Health (WISH) at 7, previously adapted to pediatric age. Hierarchical linear regression models (consecutive addition of blocks of variables based on a theoretical framework) were employed to evaluate the associations between family characteristics and adherence to the WISH at age 7 [β regression coefficients and the respective 95% confidence intervals (95%CI)]. Higher maternal age and education at child's birth were associated with increased adherence to the WISH at age 7 (β=0.018, 95%CI: 0.005, 0.031; β=0.038, 95%CI: 0.024, 0.053, respectively). A better maternal diet quality, and using more restrictive practices on child's diet, at 4 years old, were both associated with higher scoring in the WISH at 7 years old (β=0.033, 95%CI: 0.018, 0.049; β=0.067, 95%CI: 0.009, 0.125, respectively). Early maternal sociodemographic and diet quality play a significant role in influencing the adherence to a healthy and environmentally sustainable dietary pattern at school-age.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-30"},"PeriodicalIF":3.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Effects of Black Chokeberry (Aronia melanocarpa) Supplementation on Oxidative Stress, Inflammation, and Gut Microbiota". 关于 "补充黑刺李（Aronia melanocarpa）对氧化应激、炎症和肠道微生物群的影响 "的评论

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-05 DOI: 10.1017/S0007114525000133

Shubham Kumar, Ahmad Neyazi, Rachana Mehta, Ranjana Sah

引用次数: 0

The association between dietary inflammatory potential and risk of total and site-specific colorectal cancer: a systematic review and meta-analysis of observational studies.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-02-03 DOI: 10.1017/S0007114525000121

Ali Nikparast, Elahe Etesami, Mahshad Shafiee, Fatemeh Javaheri-Tafti, Arefeh Mohajerani, Matin Ghanavati

{"title":"The association between dietary inflammatory potential and risk of total and site-specific colorectal cancer: a systematic review and meta-analysis of observational studies.","authors":"Ali Nikparast, Elahe Etesami, Mahshad Shafiee, Fatemeh Javaheri-Tafti, Arefeh Mohajerani, Matin Ghanavati","doi":"10.1017/S0007114525000121","DOIUrl":"https://doi.org/10.1017/S0007114525000121","url":null,"abstract":"In the last decades, it has been well known that low grade inflammation plays a potential role in the pathogenesis of different cancers. The aim of this systematic review and meta-analysis of observational studies was to evaluate the association between inflammatory potential of diet measured through the Dietary Inflammatory Index (DII), energy-adjusted DII (E-DII), empirical dietary inflammatory pattern (EDIP) and inflammatory score of the diet (ISD) and risk of colorectal cancer (CRC) and site-specific colon cancer. A systematic electronic search of PubMed/Medline, Scopus, the Web of Sciences, and reference lists up to November 21, 2023, was performed. Data were pooled by the generic inverse variance method using random effect model. To assess the heterogeneity of included studies, the I2 index was used. A total of 28 original studies, comprising 2,287,836 participants, were selected to include in this meta-analysis. Pooled results showed a significant association between higher adherence to proinflammatory diet and increased risk of CRC (ES:1.39;95%CI:1.29-1.51;I2=82.9%), colon (ES:1.40;95%CI:1.26-1.55; I²= 73.3%, p<0.01), proximal colon (ES:1.28; 95% CI:1.17-1.40;I²=29.1%), distal (ES:1.50;95%CI:1.30-1.74;I²= 63.5%) and rectal (ES:1.46;95%CI:1.23-1.74;I²=80%). Stratified analysis by type of dietary indices noted that greater adherence to the DII, E-DII, and EDIP were related to significant increase in risk of overall CRC and site-specific colon cancers. Our results highlighted the proposed role of inflammatory protentional of diet as important risk factor for CRC. Adherence to an anti-inflammatory dietary pattern should be recommended to reduce incidence of CRC, globally.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-35"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-30 DOI: 10.1017/S000711452500011X

Kelly Pozzer Zucatti, Aline Cattani, Flávia Moraes Silva

{"title":"Reporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).","authors":"Kelly Pozzer Zucatti, Aline Cattani, Flávia Moraes Silva","doi":"10.1017/S000711452500011X","DOIUrl":"https://doi.org/10.1017/S000711452500011X","url":null,"abstract":"Studies have demonstrated that the quality and transparency of reporting Clinical Practice Guidelines (CPGs) in healthcare are low. This meta-research aimed to evaluate the adherence of nutrition CPGs for critically ill adults to the reporting RIGHT checklist and its association with the methodological quality assessed by AGREE II, along with other potential publication-related factors. A systematic search for CPGs until December 2024 was conducted. RIGHT and AGREE II were applied. Reporting completeness score was created using the data from the evaluations of whether each broken-down item of the RIGHT. Eleven CPGs were identified, none demonstrated adherence greater than 60% to the RIGHT checklist, and the mean of RIGHT score was 33.5±15.5%. There was a strong correlation between the RIGHT score and AGREE II (r=0.886). A development CPGs team including methodologist and/or statistician was associated with a higher RIGHT score (48.9±4.5 versus 27.2±11.0) and it was higher in CPGs recommended or recommended with modifications by AGREE II in comparison to those not recommended (50.1±4.6 versus 37.7±8.1 versus 17.0±6.8), and in those with acceptable and moderate compared to those with low methodological quality (50.1±4.6 versus 32.2±14.5 versus 19.3±6.2). It was also related to the language of publication, being higher in those published in English. The reporting completeness in CPGs for critically ill adults was low, with a strong correlation with the methodological quality. High values of reporting completeness scores were observed between CPGs recommended by AGREE II (with moderate or acceptable quality) and in those including a methodologist/statistician in the development team.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-38"},"PeriodicalIF":3.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal dependency on maternal fatty acids: a pilot study in human pregnancies using the natural abundance variation of ¹³C. 胎儿对母体脂肪酸的依赖性：利用13C的自然丰度变化在人类妊娠中的初步研究。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-16 DOI: 10.1017/S0007114524003222

Simonato Manuela, Verlato Giovanna, Visentin Silvia, Erich Cosmi, Anna Sartori, Pieter Sauer, Alessio Correani, Cogo Paola, Carnielli Virgilio

{"title":"Fetal dependency on maternal fatty acids: a pilot study in human pregnancies using the natural abundance variation of 13C.","authors":"Simonato Manuela, Verlato Giovanna, Visentin Silvia, Erich Cosmi, Anna Sartori, Pieter Sauer, Alessio Correani, Cogo Paola, Carnielli Virgilio","doi":"10.1017/S0007114524003222","DOIUrl":"10.1017/S0007114524003222","url":null,"abstract":"The extent of de-novo biosynthesis of non-essential fatty acids (FA) and the endogenous biosynthesis of long chain PUFA in human fetuses remain largely unknown. We used natural variations in the 13C:12C (δ 13C) of plasma phospholipids of the woman at delivery and of cord blood to infer fetal biosynthesis of FA. We studied thirty-nine mother-fetus pairs with uncomplicated pregnancies and term delivery. Eighteen women were supplemented with DHA, from pregnancy week 20 until delivery, sourced from an algae (n 13) or fish oil (n 5), each with slightly different 13C content. Twenty-one women did not receive DHA supplementation. We measured the δ 13C value of selected phospholipid FA (C16:0, C18:0, C18:1n-9, C18:2n-6, C20:4n-6 and C22:6n-3) in maternal and cord plasma samples at delivery using isotope ratio MS. We found significant linear correlations for δ 13C values of FA between mothers and their fetuses (C16:0, r = 0·8535; C18:0, r = 0·9099; C18:1n-9, r = 0·8079; C18:2n-6, r = 0·9466; C20:4n-6, r = 0·9257 and C22:6n-3, r = 0·9706). Women supplemented with algal DHA had significantly lower DHA δ 13C values in their plasma phospholipids than those supplemented with fish DHA or those who did not receive DHA supplementation (P < 0·001). There was no significant difference in δ 13C values of FA between women at delivery and their fetuses. These findings strongly suggest that the human fetus is highly dependent on the placental transport of maternal plasma FA, particularly DHA. The limited fetal biosynthesis of major FA emphasises the crucial role of maternal nutrition and placental well-being in fetal development.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"194-201"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tryptophan regulates food intake in growing pigs by modulating hypothalamic AMPK-mTOR signalling pathway. 色氨酸通过调节下丘脑AMPK-mTOR信号通路调节生长猪的摄食。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-13 DOI: 10.1017/S0007114524003210

Juexin Fan, Yuezhou Yao, Leli Wang, Feiyue Chen, Zhenguo Hu, Kaihuan Xie, Shuzhong Jiang, Xiongzhuo Tang

{"title":"Tryptophan regulates food intake in growing pigs by modulating hypothalamic AMPK-mTOR signalling pathway.","authors":"Juexin Fan, Yuezhou Yao, Leli Wang, Feiyue Chen, Zhenguo Hu, Kaihuan Xie, Shuzhong Jiang, Xiongzhuo Tang","doi":"10.1017/S0007114524003210","DOIUrl":"10.1017/S0007114524003210","url":null,"abstract":"Tryptophan (Trp) is an essential amino acid acting as a key nutrition factor regulating animal growth and development. But how Trp modulates food intake in pigs is still not well known. Here, we investigated the effect of dietary supplementation of Trp with different levels on food intake of growing pigs. The data showed that dietary Trp supplementation with the standardised ileal digestibility (SID) Trp to lysine (Lys) ratio at both 0·18 and 0·20 significantly increased the food intake by activating the expression of orexigenic gene agouti-related peptide (AgRP) and inhibiting the expression of anorexigenic gene pro-opiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART) and melanocortin receptor 4 (MC4R) in the hypothalamus. Meanwhile, the level of anorexigenic hormones appetite-regulating peptide YY (PYY) in the duodenum and serum and leptin receptor in the duodenum were also significantly decreased. Importantly, both the kynurenine and serotonin metabolic pathways were activated upon dietary Trp supplementation to downregulate MC4R expression in the hypothalamus. Further mechanistic studies revealed that the reduced MC4R expression activated the hypothalamic AMP-activated protein kinase (AMPK) pathway, which in turn inhibited the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) activity to stimulate food intake. Together, our study unravels the orexigenic effect of dietary Trp supplementation in pigs and expands its potential application in developing nutrition intervention strategy in pig production.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"269-276"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrient digestion efficiency: a comparison between broiler chickens and growing pigs fed maize, barley and oats-based diets with an emphasis on starch. 营养物质消化效率：以玉米、大麦和燕麦为基础，以淀粉为重点的饲粮的肉鸡和生长猪的比较

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-13 DOI: 10.1017/S0007114524003167

Lucas S Bassi, Marcin Hejdysz, Ewa Pruszyńska-Oszmałek, Paweł A Kołodziejski, Aaron J Cowieson, Sebastian A Kaczmarek, Birger Svihus

{"title":"Nutrient digestion efficiency: a comparison between broiler chickens and growing pigs fed maize, barley and oats-based diets with an emphasis on starch.","authors":"Lucas S Bassi, Marcin Hejdysz, Ewa Pruszyńska-Oszmałek, Paweł A Kołodziejski, Aaron J Cowieson, Sebastian A Kaczmarek, Birger Svihus","doi":"10.1017/S0007114524003167","DOIUrl":"10.1017/S0007114524003167","url":null,"abstract":"We investigated the hypotheses that broilers and pigs have distinct starch digestion capacities and that different cereals could trigger diet-species interactions. Ten replicates of two broilers (14 d old) or one pig (50 d old) each were distributed into a 3 × 2 randomised factorial design with three pelleted diets (maize, barley or oat-based) and the two species. Nutritional composition was equal for both species. Diets were fed for 10 d, and then the pancreas and organs from the stomach region and small intestine were collected with contents. It was observed that both species were similarly efficient at digesting starch but differed in some digestive aspects. Broilers had higher ileal digestibility coefficients (P < 0·001) of DM (0·69) and crude protein (0·75) than pigs (0·66 and 0·67), presented a higher volume of particles < 0·1 mm in duodenal digesta (P < 0·001) and had a lower gizzard pH (3·68) than pig stomach (4·48; P < 0·05). Conversely, pigs had lower ileal viscosity (1·44 v. 2·77 cP; P < 0·05) and higher pancreatic lipase activity (27 v. 5·9 U/g of pancreas; P < 0·05) compared with broilers. In the jejunum, oat led to higher starch digestibility (0·96; P < 0·05) than maize and barley regardless of species. In the ileum, starch digestibility was higher for broilers fed oats (0·99) than broilers fed barley (0·94; P < 0·05), establishing that oats provided, in general, a superior starch availability. The results imply that starch utilisation capacity is more related to its dietary source than to the species to which it is fed.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"182-193"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with rheumatoid arthritis: a case-control study. 成年女性类风湿关节炎患者血清总抗氧化水平、营养状况和地中海饮食依从性的评价：一项病例对照研究

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2025-01-06 DOI: 10.1017/S0007114524003386

Cansu Bekar, Berkan Armagan, Alper Sari, Aylin Ayaz

{"title":"Evaluation of serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with rheumatoid arthritis: a case-control study.","authors":"Cansu Bekar, Berkan Armagan, Alper Sari, Aylin Ayaz","doi":"10.1017/S0007114524003386","DOIUrl":"10.1017/S0007114524003386","url":null,"abstract":"Rheumatoid arthritis (RA) is characterised by chronic inflammation in joints. Obesity, stress, being women and dietary pattern are important in pathogenesis. The joint damage in RA is accelerated by oxidative stress. The aim of this study was to examine the serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with RA. Thirty-five adult women RA patients and thirty-five healthy control participated in this study (45·4 ± 11·61 and 42·5 ± 8·50 years, respectively). Nutritional status, physical activity levels and adherence to the Mediterranean diet were questioned. Physicians assessed the disease activity score of patients with RA. Serum total antioxidant and oxidant status were analysed. The serum total antioxidant status of the control group was higher, whereas the oxidative stress index and total oxidant status were lower than that of the RA group. Dietary protein, fibre, EPA, retinol, Fe, Zn and total antioxidant intake in the RA group were lower than in the control group (P < 0·05). Individuals with higher fibre intake showed a significantly lower risk for RA after adjusting for potential confounding factors (OR = 0·845, 95 % CI = 0·773-0·923, P < 0·001). The mean physical activity level of the control group was higher than that of the RA group (1·59 ± 0·10 and 1·53 ± 0·13, respectively) (P = 0·01). In conclusion, serum antioxidant parameters and dietary antioxidant intake are decreased in patients with RA. Therefore, medical treatment for these patients should be supplemented with medical nutrition therapy to achieve optimal nutritional status.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"239-245"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0