British Journal of Nutrition最新文献

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Evaluation of serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with rheumatoid arthritis: a case-control study. 成年女性类风湿关节炎患者血清总抗氧化水平、营养状况和地中海饮食依从性的评价:一项病例对照研究
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2025-01-06 DOI: 10.1017/S0007114524003386
Cansu Bekar, Berkan Armagan, Alper Sari, Aylin Ayaz
{"title":"Evaluation of serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with rheumatoid arthritis: a case-control study.","authors":"Cansu Bekar, Berkan Armagan, Alper Sari, Aylin Ayaz","doi":"10.1017/S0007114524003386","DOIUrl":"10.1017/S0007114524003386","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is characterised by chronic inflammation in joints. Obesity, stress, being women and dietary pattern are important in pathogenesis. The joint damage in RA is accelerated by oxidative stress. The aim of this study was to examine the serum total antioxidant level, nutritional status and Mediterranean diet adherence of adult women with RA. Thirty-five adult women RA patients and thirty-five healthy control participated in this study (45·4 ± 11·61 and 42·5 ± 8·50 years, respectively). Nutritional status, physical activity levels and adherence to the Mediterranean diet were questioned. Physicians assessed the disease activity score of patients with RA. Serum total antioxidant and oxidant status were analysed. The serum total antioxidant status of the control group was higher, whereas the oxidative stress index and total oxidant status were lower than that of the RA group. Dietary protein, fibre, EPA, retinol, Fe, Zn and total antioxidant intake in the RA group were lower than in the control group (<i>P</i> < 0·05). Individuals with higher fibre intake showed a significantly lower risk for RA after adjusting for potential confounding factors (OR = 0·845, 95 % CI = 0·773-0·923, <i>P</i> < 0·001). The mean physical activity level of the control group was higher than that of the RA group (1·59 ± 0·10 and 1·53 ± 0·13, respectively) (<i>P</i> = 0·01). In conclusion, serum antioxidant parameters and dietary antioxidant intake are decreased in patients with RA. Therefore, medical treatment for these patients should be supplemented with medical nutrition therapy to achieve optimal nutritional status.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"239-245"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foods provided at shelters during a heavy rain disaster: comparison of weighed food records between different numbers of days. 暴雨灾害中避难所提供的食物:不同天数间称重食物记录的比较。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-11-29 DOI: 10.1017/S0007114524003088
Hiroka Sato, Noriko Sudo, Sayaka Nagao-Sato, Nobuyo Tsuboyama-Kasaoka
{"title":"Foods provided at shelters during a heavy rain disaster: comparison of weighed food records between different numbers of days.","authors":"Hiroka Sato, Noriko Sudo, Sayaka Nagao-Sato, Nobuyo Tsuboyama-Kasaoka","doi":"10.1017/S0007114524003088","DOIUrl":"10.1017/S0007114524003088","url":null,"abstract":"<p><p>Dietitians working at evacuation shelters conduct weighed food records (WFR) for multiple days for dietary assessment. Because the menus in evacuation shelters do not change much from day to day, this study examined whether 1- and 2-d WFR are sufficient for dietary assessment at shelters and identified dietary components that can influence the number of assessment days. Overall, twenty-six WFR were collected from ten shelters in Kumamoto Prefecture, and the amounts of energy; protein; vitamins B<sub>1</sub>, B<sub>2</sub> and C and salt were calculated. Correlation analysis and paired sample tests were conducted to examine significant differences between 'one- and two-consecutive- or non-consecutive-day WFR' and 'three-consecutive-day WFR', which were set as the standard in this study. Additionally, the (CV for the categories by meal and dish were calculated to examine the variables that affected the large variations. As a result, 1-d WFR had significant positive correlations with the standard; thus, it could be used for the triage of shelters requiring nutrition assistance as a substitute for 3-d WFR. Two-consecutive-day and non-consecutive-day WFR showed a stronger correlation with the standard compared with the 1-d WFR. For energy and nutrients and dish categories, ready-to-eat foods had larger CV than boxed meals or foods from hot meal services. Whenever the meals included ready-to-eat foods, a two-non-consecutive-day WFR is recommended considering large between-day variations. Salty soup or beverages affected the variation of some nutrients. Our result would help municipalities to consider the number of WFR during emergency.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"253-261"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of food addiction and its association with type 2 diabetes: a systematic review with meta-analysis.
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 DOI: 10.1017/S000711452500008X
André Eduardo Silva Júnior, Mateus Lima Macena, Nassib Bezerra Bueno
{"title":"The prevalence of food addiction and its association with type 2 diabetes: a systematic review with meta-analysis.","authors":"André Eduardo Silva Júnior, Mateus Lima Macena, Nassib Bezerra Bueno","doi":"10.1017/S000711452500008X","DOIUrl":"https://doi.org/10.1017/S000711452500008X","url":null,"abstract":"<p><p>To determine the prevalence of FA in individuals with type 2 diabetes and to assess the association between FA and type 2 diabetes. MEDLINE, EMBASE, Web of Sciences, Latin American and Caribbean Literature in Health Sciences, ScienceDirect, Scopus, and PsycINFO were searched until November 2024. This study was registered with PROSPERO (CRD42023465903). Cross-sectional studies, case-control, cohorts, and clinical trials that were carried out with individuals with type 2 diabetes, regardless of age and sex, were included. The complete data extracted included the prevalence, odds ratio, and/or risk ratio of FA, the number of individuals evaluated, age, sex, weight, presence of comorbidities, age of participants, and FA symptoms. A pooled prevalence of FA of 30% (95% CI [18; 44] with estimated predictive interval [0; 85]; I<sup>2</sup> = 99.51; 12 studies; 15947 participants) was identified. For the associations between FA and type 2 diabetes, we found a grouped crude odds ratio value of 2.35 (95%CI [1.71; 2.98]). The pooled odds ratio adjusted for age and sex was 2.60 (95% CI [1.77; 3.42]). Finally, the odds ratio adjusted for age, sex, and body mass index (BMI) was 2.01 (95%CI [1.39; 2.64]). The results of the meta-analyses showed a high prevalence of FA in individuals with type 2 diabetes and that the associations between these two conditions remained even after adjustment for age, sex, and BMI, although with a high heterogeneity among individual estimates.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-21"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy'. 评论“头颈癌患者的肌肉减少性肥胖是放疗期间临界体重减轻的预测指标”。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-20 DOI: 10.1017/S0007114524003039
Erkan Topkan, Efsun Somay, Duriye Ozturk, Ugur Selek
{"title":"Comment on 'Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy'.","authors":"Erkan Topkan, Efsun Somay, Duriye Ozturk, Ugur Selek","doi":"10.1017/S0007114524003039","DOIUrl":"10.1017/S0007114524003039","url":null,"abstract":"","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"211-212"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial. 辅酶Q10预处理对子宫切除双侧输卵管切除术妇女卵巢储备的影响:一项随机、双盲、安慰剂对照试验
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-09 DOI: 10.1017/S0007114524003131
Kanockpetch Micaraseth, Siriluk Tantanavipas, Woradej Hongsakorn, Artitaya Singwongsa
{"title":"The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial.","authors":"Kanockpetch Micaraseth, Siriluk Tantanavipas, Woradej Hongsakorn, Artitaya Singwongsa","doi":"10.1017/S0007114524003131","DOIUrl":"10.1017/S0007114524003131","url":null,"abstract":"<p><p>The effect of diminished ovarian reserves after undergoing hysterectomies with bilateral salpingectomies is one of the health concerns among reproductive-age women with benign gynecological diseases. Coenzyme Q10 (CoQ10), an antioxidant, is crucial in mitochondrial energy production, improving oocyte quality and quantity. This study compares the benefit of a 14-d preoperative (CoQ10) <i>v</i>. placebo on ovarian reserve by measuring anti-Müllerian hormone (AMH) in women undergoing hysterectomy with bilateral salpingectomy. A double-blinded, randomised, placebo-controlled trial was conducted. Forty-four women with benign gynecological diseases were randomised to receive either oral CoQ10 300 mg per d or placebo for 14 d before undergoing hysterectomy with bilateral salpingectomy. Serum AMH levels were collected for analysis before taking CoQ10 and 6 weeks postoperatively in each group. The baseline demographic, clinical characteristics and baseline AMH levels were comparable between the groups (1·47 (0·45, 2·49) <i>v</i>. 1·29 (0·47, 2·11), <i>P</i> = 0·763). The serum AMH levels after the surgery were significantly decreased from preoperative levels (median 0·99 (0·37, 1·63) <i>v</i>. 1·34 (0·57, 2·30)), <i>P</i> = 0·001. However, there was no significant difference in the AMH change between the CoQ10 group and the placebo group (AMH per cent change -28·2 % (64·09, -4·81) <i>v</i>. -20·07 % (-61·51, -2·92)), <i>P</i> = 0·99, respectively. Age, gynecological disease, operative time and blood loss were not significantly associated with the AMH change. There were no significant side effects or adverse operative outcomes among CoQ10 users. In conclusion, hysterectomy with bilateral salpingectomy led to a significantly decreased AMH level. However, pretreatment with CoQ10 for 2 weeks was ineffective in protecting an ovarian reserve.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"213-220"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of the Global Leadership Initiative on Malnutrition criteria including systemic inflammation in patients with advanced cancer. 包括系统性炎症在内的GLIM标准在晚期癌症患者中的预后价值。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2025-01-08 DOI: 10.1017/S0007114524003271
Bruna M M Rocha, Josh McGovern, Carlos E Paiva, Ross D Dolan, Bianca S R Paiva, Daniel D Preto, Barry J Laird, Yara C P Maia, Donald C McMillan
{"title":"Prognostic value of the Global Leadership Initiative on Malnutrition criteria including systemic inflammation in patients with advanced cancer.","authors":"Bruna M M Rocha, Josh McGovern, Carlos E Paiva, Ross D Dolan, Bianca S R Paiva, Daniel D Preto, Barry J Laird, Yara C P Maia, Donald C McMillan","doi":"10.1017/S0007114524003271","DOIUrl":"10.1017/S0007114524003271","url":null,"abstract":"<p><p>An assessment of systemic inflammation and nutritional status may form the basis of a framework to examine the prognostic value of cachexia in patients with advanced cancer. The objective of the study was to examine the prognostic value of the Global Leadership Initiative on Malnutrition criteria, including BMI, weight loss (WL) and systemic inflammation (as measured by the modified Glasgow Prognostic Score (mGPS)), in advanced cancer patients. Three criteria were examined in a combined cohort of patients with advanced cancer, and their relationship with survival was examined using Cox regression methods. Data were available on 1303 patients. Considering BMI and the mGPS, the 3-month survival rate varied from 74 % (BMI > 28 kg/m<sup>2</sup>) to 61 % (BMI < 20 kg/m<sup>2</sup>) and from 84 % (mGPS 0) to 60 % (mGPS 2). Considering WL and the mGPS, the 3-month survival rate varied from 81 % (WL ± 2·4 %) to 47 % (WL ≥ 15 %) and from 93 % (mGPS 0) to 60 % (mGPS 2). Considering BMI/WL grade and mGPS, the 3-month survival rate varied from 86 % (BMI/WL grade 0) to 59 % (BMI/WL grade 4) and from 93 % (mGPS 0) to 63 % (mGPS 2). When these criteria were combined, they better predicted survival. On multivariate survival analysis, the most highly predictive factors were BMI/WL grade 3 (HR 1·454, <i>P</i> = 0·004), BMI/WL grade 4 (HR 2·285, <i>P</i> < 0·001) and mGPS 1 and 2 (HR 1·889, HR 2·545, all <i>P</i> < 0·001). In summary, a high BMI/WL grade and a high mGPS as outlined in the BMI/WL grade/mGPS framework were consistently associated with poorer survival of patients with advanced cancer. It can be readily incorporated into the routine assessment of patients.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"246-252"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between the ratio of increase in lean tissue to body weight gain and energy required to gain body weight in growing rats. 生长大鼠瘦组织增加与体重增加之比与体重增加所需能量之关系。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-19 DOI: 10.1017/S000711452400326X
Kiyora Obikawa, Mizuki Kitaguchi, Emi Kondo, Koji Okamura
{"title":"Relationship between the ratio of increase in lean tissue to body weight gain and energy required to gain body weight in growing rats.","authors":"Kiyora Obikawa, Mizuki Kitaguchi, Emi Kondo, Koji Okamura","doi":"10.1017/S000711452400326X","DOIUrl":"10.1017/S000711452400326X","url":null,"abstract":"<p><p>Although the energy stored in the lean tissue (LT) and adipose tissue (AT) is well known, the energy required to synthesise these tissues is obscure. Theoretically, the energy at the point at which ΔLT/Δ body weight (BW) reaches 100 % on a regression line, which indicates the relationship between ΔLT/ΔBW and the energy required for BW gain, is considered to be the energy expended to synthesise LT. Therefore, we investigated this relationship in rats. Rats were fed diets with different ratios of protein, fat and carbohydrates because their ΔLT/ΔBW values were expected to be different. Six-week-old male Sprague-Dawley rats had <i>ad libitum</i> access to normal (N, <i>n</i> 6), high-fat (HF, <i>n</i> 7) or high-protein (HP, <i>n</i> 8) diets for 4 weeks. The ΔLT/ΔBW was 0·77 in the N, 0·70 in the HF and 0·87 in the HP groups, respectively. The average energy required to gain BW was 8·8 kJ/g in the N group, 7·0 kJ/g in the HF group and 11·3 kJ/g in the HP group. We observed a positive correlation between ΔLT/ΔBW and energy required for BW gain. The regression line demonstrated that the energy expended to synthesise LT was 13·9 kJ/g and AT was -7·9 kJ/g. Therefore, combined with the energy stored in LT, the energy required to accumulate LT is approximately 19 kJ/g, whereas the energy to accumulate AT could not be elucidated.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"202-210"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skinny fat model of metabolic syndrome induced by a high-salt/sucrose diet in young male rats. 高盐/蔗糖饮食诱发年轻雄性大鼠代谢综合征的瘦脂肪模型。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-11-14 DOI: 10.1017/S0007114524002927
Keilah Valéria Naves Cavalcante, Marcos Divino Ferreira-Junior, Marina Conceição Dos Santos Moreira, Stefanne Madalena Marques, James Oluwagbamigbe Fajemiroye, Rosiane Aparecida Miranda, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, Carlos Henrique Xavier, Eduardo Colombari, Rodrigo Mello Gomes, Gustavo Rodrigues Pedrino
{"title":"Skinny fat model of metabolic syndrome induced by a high-salt/sucrose diet in young male rats.","authors":"Keilah Valéria Naves Cavalcante, Marcos Divino Ferreira-Junior, Marina Conceição Dos Santos Moreira, Stefanne Madalena Marques, James Oluwagbamigbe Fajemiroye, Rosiane Aparecida Miranda, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, Carlos Henrique Xavier, Eduardo Colombari, Rodrigo Mello Gomes, Gustavo Rodrigues Pedrino","doi":"10.1017/S0007114524002927","DOIUrl":"10.1017/S0007114524002927","url":null,"abstract":"<p><p>Childhood and puberty can affect metabolism, leading to tissue injury and malfunction later in life. The consumption of high-processed foods rich in salt and sugar is increasing in middle- and high-income countries, especially among young people. It is necessary to evaluate the effects of high salt and sugar levels in the youth on most injured organs during metabolic challenges. We aimed to investigate whether high-salt/sucrose intake affects whole-body development and leads to end-organ injury. Weaned male Wistar rats were divided into two groups: a control group fed a standard diet and tap water, and an experimental group (SS) fed a standard diet and a beverage containing 1·8 % NaCl and 20 % sucrose instead of tap water. The animals were treated for 60 d, starting after weaning at 21 d of age, after which the animals were subjected to glucose and insulin tolerance tests, urine collection and heart rate monitoring and euthanised for sample collection at 81 d of age. SS showed reduced body weight gain and increased food intake of sodium/sucrose solution. Interestingly, high-salt/sucrose intake led to increased body adiposity, liver lipid inclusion, heart rate and renal dysfunction. SS exhibits increased levels of PPAR alpha to counterbalance the hypertrophy of brown adipose tissue. Our findings reveal that the SS rat model exhibits non-obvious obesity with end-organ damage and preserved brown adipose tissue function. This model closely parallels human conditions with normal BMI but elevated visceral adiposity, providing a relevant tool for studying atypical metabolic disorders.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"171-181"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of n-3 very-long-chain PUFA on bone mineralisation. n-3超长链多不饱和脂肪酸对骨矿化的影响。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-11-29 DOI: 10.1017/S0007114524003052
Martina Torrissen, Elisabeth Ytteborg, Harald Svensen, Tone-Kari Østbye, Gerd Berge, Sjur Reppe, Aleksei Krasnov, Bente Ruyter
{"title":"Effects of <i>n</i>-3 very-long-chain PUFA on bone mineralisation.","authors":"Martina Torrissen, Elisabeth Ytteborg, Harald Svensen, Tone-Kari Østbye, Gerd Berge, Sjur Reppe, Aleksei Krasnov, Bente Ruyter","doi":"10.1017/S0007114524003052","DOIUrl":"10.1017/S0007114524003052","url":null,"abstract":"<p><p>The present study investigated whether dietary <i>n</i>-3 very-long-chain PUFA (<i>n</i>-3 VLC-PUFA) could increase skin and bone mineralisation in Atlantic salmon (<i>Salmo salar</i>) <i>in vivo</i> and examined their potential effects on human osteoblast proliferation and differentiation <i>in vitro</i>. Atlantic salmon were fed different dietary levels of <i>n</i>-3 VLC-PUFA, and changes in tissue <i>n</i>-3 VLC-PUFA composition, skeletal morphology, skin and bone mineral content, bone mineral density (BMD) and gene expression patterns were examined. Additionally, <i>in vitro</i> experiments using human foetal osteoblast cells were conducted to investigate the potential influence of <i>n</i>-3 VLC-PUFA supplementation on cell proliferation, osteogenic differentiation and cytokine expression. The results demonstrated that increasing the dietary levels of <i>n</i>-3 VLC-PUFA increased the mineral content of vertebrae and BMD in salmon, with subtle yet significant impacts on the expression of genes involved in bone-related processes. Furthermore, <i>in vitro</i> experiments showed a potential contextual influence of <i>n</i>-3 VLC-PUFA supplementation on gene expression of osteogenic markers and cytokine expression. Our findings indicate for the first time that <i>n</i>-3 VLC-PUFA may influence processes related to bone mineralisation.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"145-160"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet quality from mid-life and body composition in older age: findings from a British birth cohort. 中年时期的饮食质量和老年时期的身体组成:来自英国出生队列的研究结果。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-01-28 Epub Date: 2024-12-04 DOI: 10.1017/S0007114524002988
Leo D Westbury, Ruth Durdin, Sian M Robinson, Cyrus Cooper, Rachel Cooper, Kate A Ward
{"title":"Diet quality from mid-life and body composition in older age: findings from a British birth cohort.","authors":"Leo D Westbury, Ruth Durdin, Sian M Robinson, Cyrus Cooper, Rachel Cooper, Kate A Ward","doi":"10.1017/S0007114524002988","DOIUrl":"10.1017/S0007114524002988","url":null,"abstract":"<p><p>We investigated associations between 'healthy dietary pattern' scores, at ages 36, 43, 53 and 60-64 years, and body composition at age 60-64 years among participants from the MRC National Survey of Health and Development (NSHD). Principal component analyses of dietary data (food diaries) at age 60-64 years were used to calculate diet scores (healthy dietary pattern scores) at each age. Higher scores indicated healthier diets (higher consumption of fruit, vegetables and wholegrain bread). Linear regression was used to investigate associations between diet scores at each age and height-adjusted dual-energy X-ray absorptiometry-measured fat and lean mass measures at age 60-64 years. Analyses, adjusting for sex and other potential confounders (age, smoking history, physical activity and occupational class), were implemented among 692 men and women. At age 43, 53 and 60-64 years, higher diet scores were associated with lower fat mass index (FMI) and android:gynoid fat mass ratio; for example, in fully adjusted analyses, a standard deviation (sd) increase in diet score at age 60-64 years was associated with an SD difference in mean FMI of -0·18 (95 % CI: -0·25, -0·10). In conditional analyses, higher diet scores at ages 43, 53 and 60-64 years (than expected from diet scores at younger ages) were associated with lower FMI and android:gynoid fat mass ratio in fully adjusted analyses. Diet scores at age 36 years had weaker associations with the outcomes considered. No associations regarding appendicular lean mass index were robust after full adjustment. This suggests that improvements in diet through adulthood are linked to beneficial effects on adiposity in older age.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"262-268"},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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