British Journal of Nutrition最新文献

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The effects of small-quantity lipid-based nutrient supplements on adolescent physical activity and sedentary behaviour: a follow-up of the International Lipid-Based Nutrient Supplements-DYAD-Ghana trial. 少量脂质营养补充剂对青少年身体活动和久坐行为的影响:iLiNS-DYAD加纳试验的随访。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-19 DOI: 10.1017/S0007114525105126
Jonnatan Fajardo, Charles D Arnold, Mavis O Mensah, Ebenezer Adjetey, Maku E Demuyakor, Xiuping Tan, Brietta M Oaks, Seth Adu-Afarwuah, Amanda E Guyer, Kathryn G Dewey, Paul D Hastings, Elizabeth L Prado, Christine P Stewart
{"title":"The effects of small-quantity lipid-based nutrient supplements on adolescent physical activity and sedentary behaviour: a follow-up of the International Lipid-Based Nutrient Supplements-DYAD-Ghana trial.","authors":"Jonnatan Fajardo, Charles D Arnold, Mavis O Mensah, Ebenezer Adjetey, Maku E Demuyakor, Xiuping Tan, Brietta M Oaks, Seth Adu-Afarwuah, Amanda E Guyer, Kathryn G Dewey, Paul D Hastings, Elizabeth L Prado, Christine P Stewart","doi":"10.1017/S0007114525105126","DOIUrl":"10.1017/S0007114525105126","url":null,"abstract":"<p><p>Few studies have examined the effects of early-life nutrition interventions on adolescent physical activity (PA). We aimed to examine the long-term effects of small-quantity lipid-based nutrient supplements (SQ-LNS) on adolescent PA and sedentary behaviour (SB) and to describe current adolescent PA and SB levels in this cohort. In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, 1320 mothers were enrolled and randomly assigned to one of three conditions: (1) daily iron and folic acid during pregnancy and placebo (calcium) from birth to 6 months postpartum (IFA), (2) multiple micronutrient supplements during pregnancy to 6 months postpartum (MMN) or (3) SQ-LNS during pregnancy to 6 months postpartum (LNS). Infants from mothers in the LNS group received SQ-LNS designed for children from 6 to 18 months. We recruited 11-13-year-old adolescents of mothers enrolled in the iLiNS-DYAD-G trial for a 7-d PA and SB assessment using accelerometers (<i>n</i> 305) and self-reported PA and SB (<i>n</i> 508). We compared the LNS with non-LNS (IFA+MMN) groups using ANCOVA models for the following outcomes: mean vector magnitude counts per minute, PAQ-C score and percentage of time in SB, light PA and moderate-to-vigorous PA (MVPA). There were no significant differences between the LNS and non-LNS groups in any PA outcome in minimally or fully adjusted models. Only approximately 50 % of adolescents met the PA recommendation of 60 min/d MVPA, with males more active than females; however, there is room for improvement. SQ-LNS in early life does not appear to have a sustained impact on PA or SB.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: comment on 'Associations between maternal diet quality in pregnancy and infant feeding practices'. 致编辑的信:评论“孕期母亲饮食质量与婴儿喂养方法之间的关系”。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-19 DOI: 10.1017/S0007114525105163
Maria Daniele Teixeira Beltrão de Lemos, Raul Manhães de Castro, Erika Vanesa Cadena-Burbano, Ana Elisa Toscano
{"title":"Letter to the editor: comment on 'Associations between maternal diet quality in pregnancy and infant feeding practices'.","authors":"Maria Daniele Teixeira Beltrão de Lemos, Raul Manhães de Castro, Erika Vanesa Cadena-Burbano, Ana Elisa Toscano","doi":"10.1017/S0007114525105163","DOIUrl":"10.1017/S0007114525105163","url":null,"abstract":"","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caffeine enhances performance regardless of fueling strategy; however, high carbohydrate availability is associated with improved training speeds compared with ketogenic diet. 无论燃料策略如何,咖啡因都能提高表现,然而与生酮饮食相比,高CHO可用性与提高训练速度有关。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-18 DOI: 10.1017/S0007114525105084
Louise M Burke, Lucy Merrell, Ida A Heikura, Rita Civil, Avish P Sharma, Jill J Leckey, Alannah K A McKay
{"title":"Caffeine enhances performance regardless of fueling strategy; however, high carbohydrate availability is associated with improved training speeds compared with ketogenic diet.","authors":"Louise M Burke, Lucy Merrell, Ida A Heikura, Rita Civil, Avish P Sharma, Jill J Leckey, Alannah K A McKay","doi":"10.1017/S0007114525105084","DOIUrl":"10.1017/S0007114525105084","url":null,"abstract":"<p><p>The purpose of this study was to confirm reduced training metrics previously associated with a ketogenic low-carbohydrate (CHO) high-fat diet (LCHF) and investigate their attenuation with caffeine supplementation. At baseline, <i>n</i> 21 elite race-walkers followed a high CHO availability (HCHO) diet and performed a tempo hill session (14 km with a 450 m elevation gain). Athletes were then assigned to either the HCHO or LCHF in a parallel groups design for 3 weeks, where the 14 km tempo hill session was repeated each week. On weeks 2 and 3, in a randomised crossover allocation, all participants received 3 mg/kg caffeine or placebo (gum), 20 min before the session. Race-walking speed, heart rate, ratings of perceived exertion, blood metabolites and Stroop word-colour test metrics were collected. Although LCHF athletes walked faster at baseline compared with HCHO (<i>P</i> = 0·049), the HCHO group improved by week 2 (<i>P</i> = 0·009) and week 3 (<i>P</i> = 0·007), whereas the LCHF group was significantly slower in Week 1 (<i>P</i> < 0·001) and Week 2 (<i>P</i> = 0·026) compared with baseline. During the 14 km hill session, within-group analysis shows that athletes walked significantly faster (<i>P</i> = 0·010) and at a higher percentage of vVO<sub>2</sub>max (<i>P</i> = 0·007) when using caffeine compared with a placebo. Between-group differences remained present, with HCHO athletes walking at a higher percentage of vVO<sub>2</sub>max than those adhering to the LCHF diet (<i>P</i> = 0·035). No interaction between supplement treatment and dietary group occurred (<i>P</i> = 0·640). Caffeine supplementation partially reversed the performance impairment associated with an LCHF diet, but training quality remained lower than the combination of caffeine and high CHO availability.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cold and hot consumption and health outcomes among US Asian and White populations. 美国亚裔和白人人群的冷热消费与健康结果
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-18 DOI: 10.1017/S000711452510514X
Tianying Wu, Neeraja Ramesh, Cassie Doyle, Fang-Chi Hsu
{"title":"Cold and hot consumption and health outcomes among US Asian and White populations.","authors":"Tianying Wu, Neeraja Ramesh, Cassie Doyle, Fang-Chi Hsu","doi":"10.1017/S000711452510514X","DOIUrl":"10.1017/S000711452510514X","url":null,"abstract":"<p><p>This study examined the associations between cold and hot food and beverage consumption and various health outcomes among Asians and Whites in the USA. Data were drawn from 212 Asian and 203 White adults (aged 18-65 years) in the Healthy Ageing Survey. Participants reported their frequency of cold and hot drink and meal intake, along with symptoms of depression, anxiety, insomnia and gastrointestinal issues (e.g. gas, abdominal fullness). Multivariable analyses adjusted for confounders were used to assess these associations. Among Asians, higher cold consumption in summer was associated with increased anxiety (<i>β</i> = 0·24, 95 % CI: 0·05, 0·44) and abdominal fullness (<i>β</i> = 0·05, 95 % CI: 0·01, 0·86). In contrast, among Whites, higher winter hot drink intake was linked to lower insomnia (<i>β</i> = -0·23, 95 % CI: -0·42, -0·04) and gas symptoms (<i>β</i> = -0·05, 95 % CI: -0·09, -0·01). Tertile analyses showed that, compared with tertile 1, Asians in the highest tertile of summer cold drink intake had higher insomnia scores (<i>β</i> = 1·26, 95 % CI: 0·19, 2·33), while Whites in the highest tertile of winter hot drink intake had lower depression scores (<i>β</i> = -1·73, 95 % CI: -3·28, -0·18). These associations were stronger among individuals with cold hands but not observed in those without. Findings suggest that the temperature of foods and beverages may influence mental and gut health, underscoring the need to consider temperature-related dietary habits in public health and nutrition strategies, particularly across diverse populations.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High consumption of ultra-processed food and risk of colorectal cancer: the Norwegian Women and Cancer cohort study. 过量食用超加工食品与结直肠癌风险:挪威妇女和癌症队列研究
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-16 DOI: 10.1017/S0007114525105114
Rie Mols, Inge Huybrechts, Guri Skeie
{"title":"High consumption of ultra-processed food and risk of colorectal cancer: the Norwegian Women and Cancer cohort study.","authors":"Rie Mols, Inge Huybrechts, Guri Skeie","doi":"10.1017/S0007114525105114","DOIUrl":"10.1017/S0007114525105114","url":null,"abstract":"<p><p>Norway exhibits one of the highest rates of colorectal cancer (CRC) in the world, and several dietary factors have been associated with the risk of CRC. With higher consumption of ultra-processed foods (UPF), a better understanding of how food processing affects CRC might be a new approach for prevention. The current findings are contradictory, and new findings indicate that CRC risk factors might affect colorectal subsites differently. We wanted to study the association between intake of UPF and CRC risk in Norwegian women. In this prospective cohort analysis encompassing 77 100 women (1625 cases) from the Norwegian Women and Cancer study, dietary intakes were collected using validated semi-quantitative FFQ and categorised using the Nova classification system. Multivariable Cox proportional hazard models were used to assess the association between intake of UPF and CRC risk. The average follow-up time was 17·4 years. A high UPF intake (fourth quartile), compared with a low UPF intake (first quartile), was statistically significantly associated with increased total CRC risk after adjusting for all covariates and energy intake (hazard ratio (HR) = 1·24; 95 % CI 1·04, 1·49, <i>P</i><sub>for trend</sub> = 0·02). Furthermore, a high UPF intake, compared with a low UPF intake, was statistically significantly associated with right-sided colon cancer (HR = 1·58; 95 % CI 1·19, 2·09, <i>P</i><sub>for trend</sub> < 0·001). More research is needed to understand the associations between UPF, UPF subgroups and total CRC as well as cancer in colorectal subsites.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The need and strategies for increasing whole-grain intake: a narrative review focused on the UK and Ireland. 增加全谷物摄入量的需要和策略——以英国和爱尔兰为重点的叙述性回顾。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-16 DOI: 10.1017/S0007114525105059
Neil Bernard Boyle, Louise Dye, Chris J Seal
{"title":"The need and strategies for increasing whole-grain intake: a narrative review focused on the UK and Ireland.","authors":"Neil Bernard Boyle, Louise Dye, Chris J Seal","doi":"10.1017/S0007114525105059","DOIUrl":"10.1017/S0007114525105059","url":null,"abstract":"<p><p>Consuming whole grains (processed cereal grains containing all the bran, germ and endosperm), and whole-grain foods such as bread, porridge and pasta made from them, is universally recognised as beneficial for health. This is consistently shown through reduced risk and incidence of chronic diseases such as CVD, type 2 diabetes and some cancers with higher whole grain and whole-grain food intakes. Despite this, and the promotion of whole-grain foods in many food-based dietary guidelines, their consumption by the majority of global populations remains below levels predicted to improve health, particularly in the UK and Ireland. This paper (a) describes how whole grains and whole-grain foods can be better identified by consumers and food manufacturers through adoption of standard definitions and food-labelling processes, (b) summarises predicted benefits associated with higher whole-grain consumption and (c) discusses how developing population-based strategies to increase whole-grain consumption can beneficially affect dietary fibre intake, using the Danish Whole-Grain Campaign as a model for success. We suggest that the forthcoming ISO definition of whole grains as a food ingredient together with conditions of use should be adopted as soon as possible in the UK and Ireland. The health benefits of consuming more whole grain are unequivocal and should be recognised by including whole grains in dietary guidance, preferably with a minimum intake level for improved health. Public Health Agencies in the UK and Ireland should work in partnership with academics, industry and retailers to raise the profile of whole grains and whole-grain foods to improve population health.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese healthy diet and cardiometabolic multimorbidity risks: a prospective cohort study from the China Health and Nutrition Survey. 中国健康饮食与心血管代谢多病风险:来自中国健康与营养调查的前瞻性队列研究
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-15 DOI: 10.1017/S0007114525105011
Xiaofan Zhang, Huijun Wang, Yuna He, Jiguo Zhang, Xiaofang Jia, Feifei Huang, Yifei Ouyang, Bing Zhang, Xiong Xiao, Qiqi Wang, Ning Zhang, Hongmei Zhang, Fangxu Guan, Yanli Wei, Yuan Zhang, Xing Zhao, Chang Su
{"title":"Chinese healthy diet and cardiometabolic multimorbidity risks: a prospective cohort study from the China Health and Nutrition Survey.","authors":"Xiaofan Zhang, Huijun Wang, Yuna He, Jiguo Zhang, Xiaofang Jia, Feifei Huang, Yifei Ouyang, Bing Zhang, Xiong Xiao, Qiqi Wang, Ning Zhang, Hongmei Zhang, Fangxu Guan, Yanli Wei, Yuan Zhang, Xing Zhao, Chang Su","doi":"10.1017/S0007114525105011","DOIUrl":"10.1017/S0007114525105011","url":null,"abstract":"<p><p>To explore the longitudinal associations between a Chinese healthy diet and the progression of cardiometabolic multimorbidity (CMM) development among Chinese adults. A prospective analysis was conducted utilising data from 18 720 participants in the China Health and Nutrition Survey, spanning from 1997 to 2018. Dietary data were collected by three consecutive 24-h dietary recalls combined with the weighing method. A Chinese healthy diet score was developed by assigning scores to various food components. CMM was defined as the coexistence of two or more cardiometabolic diseases (CMD), including myocardial infarction, stroke and type 2 diabetes, diagnosed through blood indicators and clinical diagnosis. We employed a multistate model to examine the associations between the Chinese healthy diet and the longitudinal progression from being free of CMD to first CMD and then to CMM. Quantile G-computation was utilised to evaluate the relative contribution of each food component. Over a median follow-up period of 7·3 years, 2214 (11·8 %) participants developed first CMD, and 156 (0·83 %) progressed to CMM. Comparing participants in the highest quintile of dietary scores with those in the lowest, we observed a 55 % lower risk of transitioning from baseline to CMM (HR = 0·45, 95 % CI: 0·23, 0·87) and a 60 % lower risk of transition from first CMD to CMM (HR = 0·40, 95 % CI: 0·20, 0·81). Fresh fruits contributed to 42·8 and 43·0 % for delaying CMM and transition from first CMD to CMM, respectively. Our study revealed that greater adherence to the Chinese healthy diet is negatively associated with the risk of CMM.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between food security status and suicidal ideation: a comprehensive analysis of NHANES 2007-2016. 食品安全状况与自杀意念之间的关系:NHANES 2007-2016的综合分析。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-15 DOI: 10.1017/S0007114525105072
Wenwei Zuo, Xuelian Yang
{"title":"Associations between food security status and suicidal ideation: a comprehensive analysis of NHANES 2007-2016.","authors":"Wenwei Zuo, Xuelian Yang","doi":"10.1017/S0007114525105072","DOIUrl":"10.1017/S0007114525105072","url":null,"abstract":"<p><p>Suicidal ideation not only indicates severe psychological distress but also significantly raises the risk of suicide, whereas food insecurity may further increase this risk. To examine the relationship between food insecurity and suicidal ideation, we used the NHANES (National Health and Nutrition Examination Survey) data from 2007 to 2016. The association between the risk of suicidal ideation and food security status was examined using multivariate logistic regression models. To ensure the robustness of our findings, we also conducted subgroup and sensitivity analyses, which were crucial for assessing the consistency and precision of the research findings. This study included 22 098 participants, of whom 50·30 % were female and 49·70 % were male. In the comprehensive analysis of the population, after full adjustment, the OR were 1·14 (95 % CI 0·89, 1·46) for marginal food security, 1·40 (95 % CI 1·12, 1·76) for low food security and 1·59 (95 % CI 1·27, 1·99) for very low food security. In the subgroup analysis, we identified a significant interaction between depression and food security (<i>P</i> = 0·004). Additionally, the results of the sensitivity analysis were consistent with previous findings. Our study revealed that food insecurity significantly increased the risk of suicidal ideation, emphasising the importance of addressing food security to improve mental health. These findings support the need for national food assistance programmes integrated with mental health services. More longitudinal studies are needed to validate the long-term impact of food insecurity on suicidal ideation to optimise intervention measures and policy adjustments.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updating the Scientific Advisory Committee on Nutrition's Framework for the evaluation of evidence - CORRIGENDUM. 更新营养科学咨询委员会的证据评估框架-勘误表。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-12 DOI: 10.1017/S0007114525105060
Mamta Singh, Rachel Elsom, Adrienne Cullum, Russell J de Souza, Darren C Greenwood, David J Mela, Ken K Ong, Ian S Young, Julie A Lovegrove
{"title":"Updating the Scientific Advisory Committee on Nutrition's Framework for the evaluation of evidence - CORRIGENDUM.","authors":"Mamta Singh, Rachel Elsom, Adrienne Cullum, Russell J de Souza, Darren C Greenwood, David J Mela, Ken K Ong, Ian S Young, Julie A Lovegrove","doi":"10.1017/S0007114525105060","DOIUrl":"https://doi.org/10.1017/S0007114525105060","url":null,"abstract":"","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1"},"PeriodicalIF":3.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Ginseng Supplementation on Cardiovascular Disease Risk Factors: A Comprehensive Systematic Review and Dose-Response Meta-Analysis. 人参补充剂对心血管疾病危险因素的影响:一项综合系统评价和剂量-反应荟萃分析。
IF 3 3区 医学
British Journal of Nutrition Pub Date : 2025-09-09 DOI: 10.1017/S0007114525103607
Ali Jafari, Helia Mardani, Maryam Abbastabar, Fatemeh Mehdipoor, Bahare Parsi Nezhad, Kosar Kordkatuli, Pardis Bakhtiari Jami, Amir Hossein Faghfouri, Vali Musazadeh, Alireza Alaghi
{"title":"The Effect of Ginseng Supplementation on Cardiovascular Disease Risk Factors: A Comprehensive Systematic Review and Dose-Response Meta-Analysis.","authors":"Ali Jafari, Helia Mardani, Maryam Abbastabar, Fatemeh Mehdipoor, Bahare Parsi Nezhad, Kosar Kordkatuli, Pardis Bakhtiari Jami, Amir Hossein Faghfouri, Vali Musazadeh, Alireza Alaghi","doi":"10.1017/S0007114525103607","DOIUrl":"https://doi.org/10.1017/S0007114525103607","url":null,"abstract":"<p><p>Although numerous clinical studies suggest that ginseng supplementation may benefit cardiovascular disease (CVD) risk factors, results remain inconclusive. This systematic review and meta-analysis evaluated the effects of ginseng supplementation on CVD-related risk factors. Relevant studies were identified through electronic searches in Embase, Web of Science, Scopus, PubMed, and CENTRAL up to August 2024. Statistical analyses, including a random-effects model, meta-regression, and non-linear modeling, were used to assess heterogeneity, dose-response relationships, and the overall effects of ginseng supplementation. A total of 70 studies, published between 1998 and 2024 and involving 4,506 participants, were included. Ginseng supplementation significantly affected several biochemical markers, including high-sensitivity C-reactive protein (hs-CRP) (SMD: -0.23; 95% CI: -0.38, -0.08; P = 0.002), gamma-glutamyl transferase (GGT) (SMD: -0.20; 95% CI: -0.36, -0.04; P = 0.015), glutathione reductase (GSH-Rd) (SMD: 0.90; 95% CI: 0.38, 1.42; P = 0.001), reactive oxygen species (ROS) (SMD: -0.94; 95% CI: -1.27, -0.60; P < 0.001), and superoxide dismutase (SOD) (SMD: 0.48; 95% CI: 0.10, 0.87; P = 0.014). Meta-regression analysis showed significant linear associations between ginseng dosage and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (P = 0.044), and between supplementation duration and malondialdehyde (MDA) (P = 0.007). Dose-response analysis revealed significant associations between ginseng dose and fasting blood glucose (FBG) (P < 0.001), hs-CRP (P = 0.043), Interleukin-6 (IL-6) (P = 0.041), diastolic blood pressure (DBP) (P = 0.022), Interleukin-10 (IL-10) (P = 0.048), fasting insulin (P = 0.012), and total protein (P = 0.010). Supplementation duration was positively associated with MDA levels (P = 0.008). Ginseng supplementation was associated with improvements in inflammatory markers, liver function, and oxidative stress parameters. No significant effects were observed on anthropometric indices, blood pressure, glycemic profile, lipid profile, adipokines, or heart rate.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-107"},"PeriodicalIF":3.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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