British Journal of Nutrition最新文献

{"title":"Associations of subjective sleep patterns and social jet lag with weight loss and dietary intake in bariatric surgery patients: a 1-year follow-up study.","authors":"Aline Cunha Carvalho, Luisa Pereira Marot, Luis Augusto Mattar, José Américo Gomides de Sousa, Ana Cristina Tomaz Araújo, Camila Thais da Costa Assis, Maria Carliana Mota, Cibele Aparecida Crispim","doi":"10.1017/S0007114525000352","DOIUrl":"10.1017/S0007114525000352","url":null,"abstract":"<p><p>Current literature has shown that poor sleep patterns and social jet lag (SJL) are associated with obesity and weight gain. However, this area remains underexplored in patients who have undergone bariatric surgery. We hypothesised that higher levels of SJL and poorer sleep patterns are associated with lower weight loss, greater caloric/nutrient intake and poorer metabolic outcomes following surgery. This study aims to assess the associations of SJL and subjective sleep with anthropometric, metabolic and dietary parameters during the first year following bariatric surgery. SJL, sleep quality and daytime sleepiness were measured in 122 patients (77 % women; median age 33·0 [28·0 - 41·7]). SJL was estimated by the absolute difference between the midpoint of sleep and wake times on weekdays and weekends. Daytime sleepiness and sleep quality were evaluated using the Epworth Sleepiness Scale (Epworth) and the Pittsburgh Sleep Quality Index, respectively. Multiple linear regressions were employed to evaluate the associations of SJL, sleep quality and daytime sleepiness with weight loss, metabolic and dietary outcomes. Independent variables were negatively associated with weight loss after surgery: SJL at 6 months and 1 year; sleep quality at all time points and sleepiness after one year (<i>P</i> < 0·05). SJL was positively associated with calorie and protein intake after 1-year post-surgery (<i>P</i> < 0·05). Our results show that higher SJL and poorer sleep patterns are associated with worse anthropometric, metabolic and dietary outcomes after bariatric surgery. These findings reinforce the importance of addressing variables related to biological rhythms to optimise post-surgical outcomes in bariatric patients.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet, glutathione S-transferases M1 and T1 gene polymorphisms and cancer risk: a systematic review of observational studies.","authors":"Elham Karimi, Shalaleh Abbasnezhad, Sheida Zeraattalab-Motlagh, Reza Amiri Khosroshahi, Seyed Reza Beh-Afarin, Hamed Mohammadi, Marjan Yaghmaie","doi":"10.1017/S0007114525000327","DOIUrl":"10.1017/S0007114525000327","url":null,"abstract":"<p><p>Understanding the correlation between genes and diet holds significance in formulating tailored nutritional guidance and enhancing public health initiatives. Consequently, a thorough examination is undertaken to clarify the interplay between varying nutrient intake, glutathione S-transferases Mu1 and Theta 1 (GSTM1 & T1) gene variants and susceptibility to cancer development. In this study, we conducted a comprehensive search on MEDLINE/PubMed, Scopus and Web of Science databases up to 30 April 2023. The review included observational studies that explored the relationship between dietary consumption of acrylamide, fruits, vegetables, plant-based foods, total meat, red meat, coffee and green tea, as well as the presence of GSTM1 and T1 gene polymorphisms, and the risk of cancer in adult populations. The review findings indicated that high levels of risk factors, particularly red meat, have been linked to a higher chance of developing colorectal cancer risk among individuals with the GSTM1 null genotype. In contrast, heightened levels of protective factors, such as cruciferous vegetables, green tea, coffee and fruit, have been associated with a decreased risk of lung cancer, adult leukaemia, cutaneous melanoma and lung cancer in individuals exhibiting GST polymorphisms. There is a scarcity of comprehensive studies examining different types of cancer due to various dietary patterns and genetic variations. Research has illuminated the complex interplay among dietary factors, gene polymorphisms and cancer risk, further comprehensive studies are needed to understand and validate these findings fully. More robust investigations across diverse populations are crucial to developing personalised nutritional interventions and strengthening public health strategies.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-14"},"PeriodicalIF":3.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between diet quality indices and psoriasis severity: results from the Asking People with Psoriasis about Lifestyle and Eating (APPLE) cross-sectional study.","authors":"Sylvia Zanesco, Thiviyani Maruthappu, Christopher E M Griffiths, Kathryn V Dalrymple, Rachel Gibson, Wendy L Hall","doi":"10.1017/S0007114525000340","DOIUrl":"10.1017/S0007114525000340","url":null,"abstract":"<p><p>Psoriasis is a chronic immune-inflammatory skin disease. Cross-sectional research examining diet quality indices in psoriasis has focused on the Mediterranean diet and is confined to Mediterranean populations, thereby lacking generalisability to other populations. We explored associations between diet quality indices and the likelihood of reporting a higher psoriasis severity. This was an online cross-sectional study recruiting adult volunteers with psoriasis (<i>n</i> 257). A 147-item FFQ evaluated adherence to the Mediterranean diet score, the Dietary Approaches to Stop Hypertension score and the Plant-based Diet Index (PDI), including its original (oPDI), healthy (hPDI) and unhealthy (uPDI) subtypes. Psoriasis severity was determined with the self-assessed Simplified Psoriasis Index. When adjusted for age, sex, smoking, alcohol overconsumption, energy intake and psychological morbidity, multinomial logistic regression analyses revealed an increased likelihood of reporting a higher psoriasis severity in participants with a very low adherence to Dietary Approaches to Stop Hypertension (OR = 3·75; 95 % CI 1·313, 10·700; <i>P</i> = 0·01) and hPDI (OR = 4·04; 95 % CI 1·251, 13·064; <i>P</i> = 0·02) patterns. A reduced likelihood of reporting a higher psoriasis severity was shown in participants with low adherence to the uPDI (OR = 0·25; 95 % CI 0·085, 0·716; <i>P</i> = 0·01). With further adjustment for BMI, a very low adherence to the oPDI was significantly associated with an increased likelihood of reporting a higher psoriasis severity (OR = 3·46; 95 % CI 1·029, 11·656; <i>P</i> = 0·05). Dietary interventions and assessment should be introduced in the care pathway for psoriasis management.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dietary recommendations for reducing free sugar intakes, on free sugar intakes, dietary profiles and anthropometry: a randomised controlled trial.","authors":"Lucy R Boxall, Emily Arden-Close, Janet James, Katherine M Appleton","doi":"10.1017/S0007114525000339","DOIUrl":"10.1017/S0007114525000339","url":null,"abstract":"<p><p>Free sugar intakes are currently higher than recommended for health, yet effective strategies for reducing consumption are yet to be elucidated. This work investigated the effects of different dietary recommendations for reducing free sugar (FS) intakes, on relevant outcomes, in UK adults consuming > 5 % of total energy intake (TEI) from FS. Using a randomised controlled parallel-group design, 242 adults received nutrient-based (<i>n</i> 61), nutrient- and food-based (<i>n</i> 60), nutrient-, food- and food-substitution-based (<i>n</i> 63) or no (<i>n</i> 58) recommendations for reducing FS at a single timepoint, with effects assessed for the following 12 weeks. Primary outcomes were FS intakes as a percentage of TEI (%FS) and adherence to the recommendations at week 12. Secondary outcomes included TEI, diet composition, sugar-rich and low-calorie-sweetened food consumption and anthropometry. In intention-to-treat analyses adjusted for baseline measures, %FS reduced in intervention groups (%FS_change = -2·5 to -3·3 %) compared with control (%FS_change = -1·2 %) (smallest B = -0·573, <i>P</i> = 0·03), with effects from week 1 until week 12 and no differences between interventions (largest B = 0·352, <i>P</i> = 0·42). No effects of the interventions were found in dietary profiles, but change in %FS was associated with change in %TEI from non-sugar carbohydrate (B = 0·141, <i>P</i> < 0·01) and from protein (B = -0·171, <i>P</i> = 0·02). Body weight was also lower at week 12 in intervention groups compared with control (B = -0·377, <i>P</i> < 0·05), but associations with %FS were weak. Our findings demonstrate the benefit of dietary recommendations for reducing FS intakes in UK adults. Limited advantages were found for the different dietary recommendations, but variety may offer individual choice.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal intake of dairy products is inversely associated with birth weight in women with gestational diabetes mellitus: a prospective cohort study.","authors":"Cuiling Xie, Qing Xiang Zheng, Xiumin Jiang, Yanping Liao, Xiaoxia Gao, Yu Zhu, Jianing Li, Rulin Liu","doi":"10.1017/S0007114525000224","DOIUrl":"10.1017/S0007114525000224","url":null,"abstract":"<p><p>This study aimed to investigate the intake of dairy products during pregnancy in women with gestational diabetes mellitus (GDM) and its impacts on neonatal birth weight and pregnancy outcomes. A total of 386 women with GDM during the second trimester pregnancy participated in this prospective cohort study. We evaluated dairy products intake through the FFQ. Pregnancy outcomes were obtained from the delivery data. Participants were divided into insufficient and sufficient intake of milk and dairy products groups (< 300 g/d and ≥ 300 g/d, respectively). The average intake of dairy products during the second trimester pregnancy in women with GDM was 317·8 ± 179·5 g/d, and the total energy intake was 1635·4 ± 708·7 kcal/d. However, 76·68 % of them did not meet the recommended total energy intake of women with GDM. After adjusting for confounding factors, women with GDM who consumed ≥ 300 g/d of dairy products had an average reduction in birth weight of 93·1 g compared with women who consumed < 300 g/d of dairy products (95 % CI -171·343, -14·927). Women with GDM in sufficient intake group was also associated with lower risk of macrosomia (95 % CI 0·043, 0·695) and caesarean section (95 % CI 0·387, 0·933) and not related to low birth weight infant (95 % CI 0·617, 14·502) and preterm birth (95 % CI 0·186, 1·510) when compared with participants in insufficient intake group. Under the premise of insufficient total energy intake, the intake of dairy products during the second trimester pregnancy in women with GDM might be related to the decrease of neonatal birth weight.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absorption, accumulation and metabolism of cetoleic acid from dietary herring oil in tissues of male Zucker Diabetic Sprague Dawley rats.","authors":"Eira V Rimmen, Svein Are Mjøs, Eirik Søfteland, Oddrun A Gudbrandsen","doi":"10.1017/S0007114525000236","DOIUrl":"10.1017/S0007114525000236","url":null,"abstract":"<p><p>Accumulation of exogenous fatty acids such as the long-chain <i>n</i>-11 MUFA cetoleic acid (CA, C22:1<i>n</i>-11) may induce functional changes, through direct effects or by affecting the amounts of other fatty acids through changes in catabolic and anabolic processes including desaturation of fatty acids or by other processes. The primary aim of this study was to investigate if dietary CA was absorbed and accumulated in a TAG-rich tissue for storage (white adipose tissue), a stable phospholipid-rich tissue (brain), metabolically active tissues (liver and skeletal muscle) or circulating in the blood (blood cells) and metabolised. Secondary aims included investigating any effects on the levels of EPA and DHA. Eighteen male Zucker diabetic Sprague Dawley (ZDSD) rats were fed diets with herring oil (HERO) containing 0·70 % CA or anchovy oil (ANCO) devoid of CA, or a control diet with soyabean oil for 5 weeks. The HERO and ANCO diets contained 0·35 and 0·37 wt% EPA + DHA, respectively. Data were analysed using one-way ANOVA. CA from dietary HERO was absorbed, and CA and two chain-shortened metabolites were found in blood cells, liver, white adipose tissue (WAT) and muscle, but <i>n</i>-11 MUFAs were not found in the brain. The concentrations of EPA and DHA were similar in liver lipids (TAG, cholesteryl esters and NEFA) as well as in WAT, muscle and brain from rats fed the HERO or ANCO diets. To conclude, CA was taken up by tissues but did not affect levels of EPA and DHA in this diabetic rat model.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of breakfast consumption timing <i>v</i>. breakfast omission on post-lunch glycaemia and insulinaemia in adolescent girls: a randomised crossover trial.","authors":"Sahar Afeef, Julia K Zakrzewski-Fruer, Alice E Thackray, Laura A Barrett, Keith Tolfrey","doi":"10.1017/S0007114525000248","DOIUrl":"10.1017/S0007114525000248","url":null,"abstract":"<p><p>Adolescent girls often skip breakfast due to time constraints and reduced morning appetite. This study examined the acute impact of breakfast consumption timing <i>v</i>. breakfast omission (BO) on glycaemic and insulinaemic responses to lunch in infrequent breakfast-consuming girls. Fifteen girls (13·1 (sd 0·8) years) completed three conditions in a randomised crossover design: early-morning breakfast consumption (EM-BC; 08.30), mid-morning breakfast consumption (MM-BC; 10.30) and BO. A standardised lunch was provided at 12.30, followed by a 2-h post-lunch observation period. Blood and expired gas samples were collected periodically. Linear mixed models with Cohen's <i>d</i> effect sizes compared outcomes between conditions. Pre-lunch glucose and insulin incremental AUC (iAUC) were higher in the breakfast conditions <i>v</i>. BO (<i>P</i> ≤ 0·009), with no differences between breakfast conditions. MM-BC reduced post-lunch glucose iAUC by 36 % and 25 % compared with BO and EM-BC, respectively (<i>P</i> < 0·001, <i>d</i> = 0·92-1·44). A moderate, non-significant 15 % reduction in post-lunch glucose iAUC was seen with EM-BC <i>v</i>. BO (<i>P</i> = 0·077, <i>d</i> = 0·52). These reductions occurred without changes in post-lunch insulinemia (<i>P</i> ≥ 0·323) and were accompanied by increased post-lunch carbohydrate oxidation compared with BO (<i>P</i> ≤ 0·018, <i>d</i> = 0·58-0·75); with no differences between EM-BC and MM-BC. MM-BC lowered glycaemic response over the experimental period compared with BO (<i>P</i> = 0·033, <i>d</i> = 0·98) and EM-BC (<i>P</i> = 0·123, <i>d</i> = 0·93), with no difference between EM-BC and BO. Compared with BO, both breakfast conditions lowered post-lunch glycaemic responses with mid-morning breakfast eliciting a greater second-meal effect than early-morning breakfast. These findings indicate the breakfast-to-lunch meal interval may be a crucial factor affecting postprandial glycaemia in infrequent breakfast-consuming girls.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal diet quality in pregnancy and infant feeding practices.","authors":"Meaghan J Sexton-Dhamu, Katherine M Livingstone, Ewa A Szymlek-Gay, Li Ming Wen, Miaobing Zheng","doi":"10.1017/S000711452500025X","DOIUrl":"10.1017/S000711452500025X","url":null,"abstract":"<p><p>Postpartum maternal diet quality has been linked with optimal infant feeding practices. However, whether maternal diet quality during pregnancy influences infant feeding practices remains unclear. The present study explored the relationship between maternal diet quality in pregnancy and infant feeding practices in Australian women. A brief 15-item FFQ was used to collect maternal dietary data (<i>n</i> 469). Diet quality was calculated using a modified 2013 Dietary Guideline Index (DGI). Multivariable linear and logistic regressions with adjustment for covariates were used to examine associations between maternal diet quality in pregnancy and infant feeding practices: infant feeding mode, breast-feeding duration and timing of solids introduction. Higher DGI score during pregnancy was associated with higher odds of breast-feeding than formula/mixed feeding (adjusted OR (AOR) 1·03, 95 % CI 1·00, 1·07), longer breast-feeding duration (adjusted <i>β</i> 0·09, 95 % CI 0·03, 0·15) and higher odds of breast-feeding for ≥ 6 months (AOR 1·04, 95 % CI 1·02, 1·07) than for < 6 months. Associations between maternal DGI score and breast-feeding variables were moderated by maternal country of birth, with significant associations observed in Australian-born mothers only. No association was found between maternal DGI score and timing of solids introduction. Higher maternal diet quality was associated with better infant feeding practices, and the association was moderated by country of birth. Our findings provide evidence to support the initiation of dietary interventions to promote diet quality during pregnancy, particularly among Australian-born women. Further research could explore underlying mechanisms linking maternal diet quality and infant feeding practices.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of vitamin K (phylloquinone and menaquinones 4-10) in various shellfish.","authors":"Amalie Moxness Reksten, Kari Elin Rød, Inger Aakre, Lise Madsen, Kristin Holvik, Sigrun Henjum, Eystein Oveland, Lisbeth Dahl","doi":"10.1017/S0007114525000261","DOIUrl":"10.1017/S0007114525000261","url":null,"abstract":"<p><p>Vitamin K exists naturally in foods as phylloquinone (vitamin K₁, PK) and as a range of menaquinones (vitamin K₂, MK). There is scarce information on the occurrence and distribution of PK and MK in dietary sources, particularly in seafood. This study aimed to comprehensively analyse the contents of vitamin K_1, dihydro-K₁, and MK-4 to MK-10 in various species, tissue types and processing degrees of shellfish. Additionally, seasonal differences in the vitamin K content of blue mussels (<i>Mytilus edulis</i>) were explored. Most shellfish products had low contents of total vitamin K (< 10 µg/100 g). The highest content of total vitamin K was found in the hepatopancreas of snow crab (170 µg/100 g), the brown meat of brown crab (35 µg/100 g), pre-packaged blue mussels (20 µg/100 g), stuffed brown crab shells (15 µg/100 g) and blue mussels in brine (12 µg/100 g). In general, the hepatopancreas of crustaceans contained considerably higher contents of vitamin K than their white meat counterparts. MK contributed most to total vitamin K contents, whereas most shellfish products contained low contents of PK, thus making only a minor contribution to the adequate intake established for adults. No statistically significant differences were observed in PK and MK contents of blue mussels sampled during spring <i>v</i>. late summer (<i>P</i> < 0·005). Nevertheless, a non-significant trend of increasing vitamin K content was observed towards the autumn months. This study presents novel vitamin K data for shellfish, an unexplored food group, and adds to the scarce vitamin K composition data worldwide.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of moderate wine consumption on the activity of enzymes involved in platelet-activating factor metabolism and thrombotic biomarkers: a randomised, single-blind, parallel, clinical study in CHD men patients.","authors":"Elizabeth Fragopoulou, Chrysa Argyrou, Eleni Matalliotaki, Christos Pafilas, Maria Detopoulou, Smaragdi Antonopoulou, Genovefa Kolovou, Petros Kalogeropoulos","doi":"10.1017/S0007114525000273","DOIUrl":"10.1017/S0007114525000273","url":null,"abstract":"<p><p>A randomised parallel intervention study was conducted with male patients diagnosed with CHD. Participants were assigned to three groups: Group A abstained from alcohol (<i>n</i> 20), Group B consumed red wine (<i>n</i> 21) and Group C (<i>n</i> 16) consumed an alcoholic beverage without wine micro-constituents. Biological samples were collected at baseline, 4 and 8 weeks. Enzyme activities of acetyl-CoA:lyso-platelet-activating factor (PAF) acetyltransferase, cytidine 5'-diphospho (CDP)-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-cholinephosphotransferase), PAF-acetylhydrolase in leukocyte homogenates, serum lipoprotein-associated phospholipase-A₂ and plasma markers of thrombosis were measured. PAF-, ADP- and collagen-induced platelet aggregation was measured in human platelet-rich plasma. Red wine consumption led to a 15·3 % reduction in LysoPAF-acetyltransferase activity at 4 weeks (<i>P</i>= 0·008) compared with baseline and Group A (<i>P</i>= 0·01). PAF-cholinephosphotransferase activity was reduced by 11·1 % at 8 weeks (<i>P</i>= 0·04) compared with baseline and by 24·9 % compared with Group C (<i>P</i>= 0·02). PAF-acetylhydrolase activity was reduced by 36·2 % at 8 weeks compared with baseline (<i>P</i>= 0·001) and compared with Group A (<i>P</i>< 0·000) and Group C (<i>P</i>= 0·009). Fibrinogen levels in Group B reduced by 6-9 % at 4 (<i>P</i>= 0·04) and 8 weeks (<i>P</i>= 0·01) compared with baseline while D-dimer in Group C increased by 16·1 % at 8 weeks (<i>P</i>= 0·005) compared with baseline. Platelet aggregation against PAF and collagen was reduced in Group B (82·6 and 35·4 %, respectively), and in Group C (158·4 and 37·1 %, respectively) compared with baseline and Group A (<i>P</i>< 0·05). In conclusion, moderate wine consumption improved the activity of PAF-metabolism enzymes regardless of ethanol and reduced platelet aggregation, probably through mechanisms different from those of ethanol.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}