British Journal of Nutrition最新文献

{"title":"Effect of moderate wine consumption on the activity of enzymes involved in platelet-activating factor metabolism and thrombotic biomarkers: a randomised, single-blind, parallel, clinical study in CHD men patients.","authors":"Elizabeth Fragopoulou, Chrysa Argyrou, Eleni Matalliotaki, Christos Pafilas, Maria Detopoulou, Smaragdi Antonopoulou, Genovefa Kolovou, Petros Kalogeropoulos","doi":"10.1017/S0007114525000273","DOIUrl":"10.1017/S0007114525000273","url":null,"abstract":"<p><p>A randomised parallel intervention study was conducted with male patients diagnosed with CHD. Participants were assigned to three groups: Group A abstained from alcohol (<i>n</i> 20), Group B consumed red wine (<i>n</i> 21) and Group C (<i>n</i> 16) consumed an alcoholic beverage without wine micro-constituents. Biological samples were collected at baseline, 4 and 8 weeks. Enzyme activities of acetyl-CoA:lyso-platelet-activating factor (PAF) acetyltransferase, cytidine 5'-diphospho (CDP)-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-cholinephosphotransferase), PAF-acetylhydrolase in leukocyte homogenates, serum lipoprotein-associated phospholipase-A₂ and plasma markers of thrombosis were measured. PAF-, ADP- and collagen-induced platelet aggregation was measured in human platelet-rich plasma. Red wine consumption led to a 15·3 % reduction in LysoPAF-acetyltransferase activity at 4 weeks (<i>P</i>= 0·008) compared with baseline and Group A (<i>P</i>= 0·01). PAF-cholinephosphotransferase activity was reduced by 11·1 % at 8 weeks (<i>P</i>= 0·04) compared with baseline and by 24·9 % compared with Group C (<i>P</i>= 0·02). PAF-acetylhydrolase activity was reduced by 36·2 % at 8 weeks compared with baseline (<i>P</i>= 0·001) and compared with Group A (<i>P</i>< 0·000) and Group C (<i>P</i>= 0·009). Fibrinogen levels in Group B reduced by 6-9 % at 4 (<i>P</i>= 0·04) and 8 weeks (<i>P</i>= 0·01) compared with baseline while D-dimer in Group C increased by 16·1 % at 8 weeks (<i>P</i>= 0·005) compared with baseline. Platelet aggregation against PAF and collagen was reduced in Group B (82·6 and 35·4 %, respectively), and in Group C (158·4 and 37·1 %, respectively) compared with baseline and Group A (<i>P</i>< 0·05). In conclusion, moderate wine consumption improved the activity of PAF-metabolism enzymes regardless of ethanol and reduced platelet aggregation, probably through mechanisms different from those of ethanol.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the understanding of dietary total antioxidant capacity and skeletal muscle mass: addressing key limitations and future directions.","authors":"Zhongxing Liu, Mengzhe Tian, Lincheng Duan","doi":"10.1017/S0007114525000285","DOIUrl":"10.1017/S0007114525000285","url":null,"abstract":"","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-2"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment on 'Effects of Black Chokeberry (<i>Aronia melanocarpa</i>) Supplementation on Oxidative Stress, Inflammation, and Gut Microbiota'.","authors":"Sabina Kaczmarczyk, Hanna Dziewiecka, Anna Kasperska, Marta Pasek, Joanna Ostapiuk-Karolczuk, Anna Skarpańska-Stejnborn","doi":"10.1017/S0007114525000145","DOIUrl":"10.1017/S0007114525000145","url":null,"abstract":"","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-2"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of wasting and overweight in Brazilian children between 6 and 59 months: Brazilian National Survey on Child Nutrition (ENANI-2019).","authors":"Dayana Rodrigues Farias, Luiz Antonio Anjos, Talita Lelis Berti, Nadya Helena Alves-Santos, P G Andrade, Maiara Brusco de Freitas, J Lepsch, Natália Oliveira, Elisa M A Lacerda, Letícia Barroso V Carneiro, Raquel Machado Schincaglia, P Normando, Ines Rugani Ribeiro de Castro, Gilberto Kac","doi":"10.1017/S0007114525000297","DOIUrl":"10.1017/S0007114525000297","url":null,"abstract":"<p><p>Understanding the determinants of malnutrition is pivotal for public health interventions. This study aimed to identify socio-economic, demographic, dietary and maternal determinants of wasting and overweight among Brazilian children between 6 and 59 months. Data from the Brazilian National Survey on Child Nutrition were analysed (<i>n</i> 11 789). Children's weight-for-height Z-scores were calculated according to the WHO growth standard and classified as wasting (Z < -2), normal weight (-2 ≤ Z ≤ 1), overweight risk (1 < Z ≤ 2) and overweight (Z > 2). Socio-economic, demographic, dietary and maternal covariables were considered. Adjusted multinomial logistic regression (OR and 95 % CI) was employed. The prevalence of overweight and wasting was 9·5 and 2·6 %, respectively. In the adjusted model, younger age (6-23 months: OR: 1·7; 95 % CI: 1·3, 2·2), consumption of ≥ 5 ultra-processed food groups (OR: 1·8; 95 % CI: 1·1, 3·1), maternal underweight (OR: 0·4; 95 % CI: 0·2, 0·9), overweight (OR: 1·5; 95 % CI: 1·2, 1·9) and mild food insecurity (OR: 0·8; 95 % CI: 0·6, 1·0) were associated with child overweight. The Brazilian Northeast (OR: 4·9; 95 % CI: 2·1, 11·3), Southeast (OR: 7·1; 95 % CI: 3·0, 16·6), South (OR: 4·7; 95 % CI: 1·8, 12·1), Midwest regions (OR: 2·7; 95 % CI: 1·2, 6·2) and maternal underweight (OR: 5·4; 95 % CI: 2·7, 10·7) were associated with wasting. Overweight in Brazil is prevalent among children between 6 and 59 months, while wasting is not a major public health problem. The main determinants of these Brazilian children's nutritional status were age, ultra-processed food consumption and maternal nutritional status.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum insulin-like growth factor 1 in young children with moderate acute malnutrition: secondary analysis of a randomised trial in Burkina Faso.","authors":"Thora W Helt, Bernardette Cichon, Christian Fabiansen, Ann-Sophie Iuel-Brockdorff, Charles W Yaméogo, Christian Ritz, André Briend, Kim F Michaelsen, Suzanne Filteau, Henrik Friis, Vibeke B Christensen, Benedikte Grenov","doi":"10.1017/S0007114525000212","DOIUrl":"10.1017/S0007114525000212","url":null,"abstract":"<p><p>Insulin-like growth factor 1 (IGF-1) is an important growth factor in childhood. We aimed to investigate the impact of food supplements for the treatment of moderate acute malnutrition (MAM) on serum IGF-1 (sIGF-1). Secondary analysis of a randomised 2 × 2 × 3 factorial nutrition trial was performed. Children aged 6-23 months with MAM received 2093 kJ/d as lipid-based nutrient supplement (LNS) or corn soy blend (CSB), containing either dehulled soya or soya isolate and different quantities of dried skimmed milk (0 %, 20 % or 50 % of total protein) for 12 weeks. The trial was double-blind with regard to soya and milk but not to matrix (LNS <i>v</i>. CSB). sIGF-1 was measured at inclusion and after 12 weeks of supplementation. Of 1609 children enrolled, 1455 (90 %) had sIGF-1 measured at both time points. During supplementation, sIGF-1 increased 6·7 (95 % CI 6·1, 7·3) ng/ml compared with an expected age-dependent decrease of 0·3 (95 % CI 0·2, 0·4) ng/ml. Children who received LNS <i>v</i>. CSB had a lower increase in sIGF-1 (-8 %, 95 % CI - 12, -3). The effect of LNS was partly attenuated when sIGF-1 was corrected for inflammation. Children who received soya isolate compared with dehulled soya had a higher increase in sIGF-1 (6 %, 95 % CI 1, 12). Milk content did not affect sIGF-1. Overall, sIGF-1 increased during supplementation. The lower increase with LNS <i>v</i>. CSB was only partly explained by increased inflammation with LNS and needs further investigation. Isolate <i>v</i>. dehulled soya led to a higher increase which may be due to antinutrients in dehulled soya.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary glycaemic index and insulin index in association with incident type 2 diabetes mellitus in adults.","authors":"Peyman Sarsangi, Mohammad Mohammadi, Azadeh Nadjarzadeh, Amin Salehi-Abargouei, Ahmad Esmaillzadeh, Masoud Mirzaei","doi":"10.1017/S0007114524002307","DOIUrl":"10.1017/S0007114524002307","url":null,"abstract":"<p><p>There is a lack of information from Middle Eastern countries regarding diet-disease associations. We examined dietary glycaemic and insulinemic potential in relation to risk of incident diabetes among a large group of Iranian adults. The present study was carried out using data from Yazd Health Study-Taghzieh Mardom Yazd, a prospective cohort study on adults aged 20-70 years in Yazd Greater Area, Iran. This study was initiated in 2014-2016 (baseline examination), and data are collected prospectively at one 5-year intervals. Data on demographic characteristics, dietary intakes and potential confounders were gathered by interview. During the follow-up phase of the study, diabetes incidence was confirmed by laboratory tests and physician diagnoses. This study included a total of 6178 participants in the cross-sectional analysis and 5105 subjects in the prospective phase. Examining the cross-sectional phase, we failed to find any significant association between dietary glycaemic index (GI) and glycaemic load (GL) as well as dietary insulin index (DII) or dietary insulin load (DIL) and prevalence of diabetes. No significant relationship was also seen between DII/DIL and risk of T2DM in the prospective phase; however, in the stratified analysis by BMI status, there was an inverse significant association between DII and risk of type 2 diabetes mellitus (hazard ratio for T3 <i>v</i>. T1: 0·19; 95 % CI: 0·04, 0·92; <i>P</i> = 0·03) in non-obese (BMI ≥ 25 kg/m²) and overweight (BMI < 25 kg/m²) participants. No significant association was found between dietary GI/ dietary GL/ DII/ or DIL with risk of T2DM. More research, particularly with a longer follow-up duration, is needed to confirm these findings.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.","authors":"Isabelle Durocher, Daniel S Grant, Marc R Bomhof","doi":"10.1017/S0007114525000194","DOIUrl":"10.1017/S0007114525000194","url":null,"abstract":"<p><p>The influence of appetite and energy intake (EI) on energy compensation in response to chronic exercise remains poorly understood. This study examined the temporal impact of habitual exercise on EI and the homeostatic appetite regulators that influence energy compensation. Twelve-week-old male Sprague Dawley rats (<i>n</i> 30) fed an AIN-93M diet were randomised into one of three groups: (1) sedentary control (SED); (2) voluntary wheel exercise (EX) and (3) sedentary, weight-matched to aerobic exercise (SED-WM) for 8 weeks. Measures of EI, body weight and adiposity were assessed. Appetite-regulating hormones acyl ghrelin, active glucagon-like peptide (GLP)-1, leptin and insulin were measured in response to an oral glucose tolerance test. Rats with running wheels completed an average of 192 km over 8 weeks. While EI was initially reduced in EX, EI gradually increased with exercise training after week 1 (<i>P</i> < 0·05). Body weight was lower in EX relative to SED from weeks 3 to 5 but did not differ at the end of the study. Fat mass and long-term satiety hormones leptin and insulin were lower in EX (<i>P</i> < 0·05). No differences were observed in concentrations of the satiety hormone active GLP-1 or the orexigenic hormone acyl ghrelin. Short-term homeostatic regulators of appetite do not appear to be altered with exercise training. The reduction in adiposity and associated decrease in tonic satiety hormones leptin and insulin are likely contributors to the coupling of energy expenditure with EI over time with voluntary exercise.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of probiotic supplementation on intestinal flora, brain-gut peptides and clinical outcomes in children with anorexia nervosa.","authors":"Xiaoyan Lu, Yali Liu, Longxia Hao, Junqiong Li, Linjuan Hua","doi":"10.1017/S0007114525000169","DOIUrl":"10.1017/S0007114525000169","url":null,"abstract":"<p><p>This study aims to assess the therapeutic effects of probiotic oral therapy in paediatric patients with anorexia nervosa (AN) and to investigate its impact on intestinal flora composition, brain-gut peptide levels and overall clinical outcomes. A retrospective study was conducted involving 100 children diagnosed with AN at Xingtang County People's Hospital between January 2023 and June 2024. Patients were divided into two groups: a control group (<i>n</i> 50) receiving zinc gluconate oral solution alone and an observation group (<i>n</i> 50) receiving zinc gluconate plus probiotics. Outcome measures included intestinal flora analysis, brain-gut peptide levels (somatostatin (SS) and nitric oxide (NO)), clinical efficacy, serum trace element levels (Ca, Zn and Fe) and prognosis, including recurrence rates 6 months post-treatment. Baseline characteristics were similar between the two groups (<i>P</i> > 0·05). After treatment, the observation group showed significantly higher levels of Bifidobacterium and Lactobacillus and lower levels of Enterobacter compared with the control group (<i>P</i> < 0·05). Additionally, the observation group had lower levels of SS and NO (<i>P</i> < 0·05), indicating improved brain-gut communication. Clinical efficacy was significantly higher in the observation group (<i>P</i> < 0·05), with improved serum trace element levels (<i>P</i> < 0·05 for Ca, Zn and Fe). Furthermore, the recurrence rate 6 months post-treatment was significantly lower in the observation group compared with the control group (<i>P</i> < 0·05). Probiotic supplementation in children with AN effectively modulates intestinal flora, improves brain-gut peptide levels and enhances clinical outcomes.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Children's adherence to a healthy and environmentally sustainable dietary pattern based on the EAT-Lancet recommendations: the role of the family environment.","authors":"Beatriz Teixeira, Cláudia Afonso, Andreia Oliveira","doi":"10.1017/S0007114525000157","DOIUrl":"10.1017/S0007114525000157","url":null,"abstract":"<p><p>This study aimed to investigate the association between family characteristics and adherence to the EAT-Lancet dietary recommendations in 7-year-old children. This is a prospective birth cohort study with 2125 children from Generation XXI (Porto, Portugal), who provided 3-day food diaries at age 7, used to assess habitual food consumption. At the age of 4, maternal diet was assessed using a Food Frequency Questionnaire, and a diet quality score was calculated (higher scores indicating a better maternal diet), and parental-child feeding practices were assessed with the Child Feeding Questionnaire. Adherence to the EAT-Lancet dietary recommendations was evaluated using the World Index for Sustainability and Health (WISH) at the age of 7 years, previously adapted to paediatric age. Hierarchical linear regression models (consecutive addition of blocks of variables based on a theoretical framework) were employed to evaluate the associations between family characteristics and adherence to the WISH at age 7 (<i>β</i> regression coefficients and the respective 95 % confidence intervals (95 % CI)). Higher maternal age and education at child's birth were associated with increased adherence to the WISH at age 7 (<i>β</i> = 0·018, 95 % CI 0·005, 0·031; <i>β</i> = 0·038, 95 % CI 0·024, 0·053, respectively). A better maternal diet quality and using more restrictive practices on child's diet, at 4 years old, were both associated with higher scoring in the WISH at 7 years old (<i>β</i> = 0·033, 95 % CI 0·018, 0·049; <i>β</i> = 0·067, 95 % CI 0·009, 0·125, respectively). Early maternal sociodemographic and diet quality play a significant role in influencing the adherence to a healthy and environmentally sustainable dietary pattern at school-age.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'effects of black chokeberry (<i>Aronia melanocarpa</i>) supplementation on oxidative stress, inflammation and gut microbiota'.","authors":"Shubham Kumar, Ahmad Neyazi, Rachana Mehta, Ranjana Sah","doi":"10.1017/S0007114525000133","DOIUrl":"10.1017/S0007114525000133","url":null,"abstract":"","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-2"},"PeriodicalIF":3.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}