British Journal of Nutrition最新文献_第7页

Reproducibility and validity of dietary polyphenols derived from 24-h dietary recalls in the Anhui Lifestyle Validation Study. 安徽生活方式验证研究中24小时膳食回顾中膳食多酚的可重复性和有效性。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-04 DOI: 10.1017/S0007114526108174

Guobing Sun, Meiling Li, Jiawei Zhang, Junyi Zhang, Hongjuan Cao, Young Lyu, Xinghao Ma, Yu Han, Xinsheng Qin, Zhuang Zhang, Wanshui Yang

{"title":"Reproducibility and validity of dietary polyphenols derived from 24-h dietary recalls in the Anhui Lifestyle Validation Study.","authors":"Guobing Sun, Meiling Li, Jiawei Zhang, Junyi Zhang, Hongjuan Cao, Young Lyu, Xinghao Ma, Yu Han, Xinsheng Qin, Zhuang Zhang, Wanshui Yang","doi":"10.1017/S0007114526108174","DOIUrl":"10.1017/S0007114526108174","url":null,"abstract":"While 24-h dietary recalls (24HDR) are increasingly used to assess polyphenol-disease associations, their performance for measuring total dietary polyphenols and their subclasses remains unknown. In the Anhui Lifestyle Validation Study, 432 community-dwelling adults completed 12-d dietary recalls, structured as four seasonal sets of three consecutive 24HDR (2 weekdays and 1 weekend day each) between July 2021 and July 2022. Reproducibility of dietary total polyphenols, flavonoids, lignans and phenolic acids assessed by different number of non-consecutive 24HDR was evaluated by intraclass correlation coefficient (ICC). Relative validity was evaluated by comparing estimates from different numbers of 24HDR with the internal reference using deattenuated Spearman's correlation coefficients (rc). The reproducibility from two 24HDR was weak for these four polyphenol categories (ICC: 0·10-0·39), while three 24HDR yielded a reasonable reproducibility for total polyphenols (ICC: 0·40, 95 % CI 0·31-0·50), flavonoids (ICC: 0·42, 95 % CI 0·33-0·51) and phenolic acids (ICC: 0·45, 95 % CI 0·16-0·66), but not for lignans (ICC: 0·11, 95 % CI 0·01-0·26). Increasing days up to 4-6 seemed not to appreciably improve the reproducibility (ICC range: 0·13-0·17 for lignans, 0·41-0·56 for others). The relative validity against the internal reference of these four polyphenol categories was moderate for two 24HDR (rc: 0·50-0·74) and improved for ≥ 3 24HDR (r c : 0·76-1·00). Older age, female sex and weekend administration were associated with lower reproducibility of three 24HDR-based assessments of phenolic acids or flavonoids. Overall, our results suggest that three non-consecutive 24HDR may have acceptable performance in measuring most dietary polyphenol intake except for lignans.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-9"},"PeriodicalIF":3.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of 3-day turmeric supplementation on fasting and postprandial LPS and chylomicron-related markers in patients with IBS: A randomized crossover trial. 补充3天姜黄对肠易激综合征患者空腹和餐后脂多糖和乳糜微粒相关标志物的影响：一项随机交叉试验

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-03 DOI: 10.1017/S0007114526108101

Maartje van den Belt, Lonneke JanssenDuijghuijsen, Monic Tomassen, Nicole de Roos, Ben Witteman, Pascale Fança-Berthon, Julie Laval, Nicole de Wit

{"title":"Impact of 3-day turmeric supplementation on fasting and postprandial LPS and chylomicron-related markers in patients with IBS: A randomized crossover trial.","authors":"Maartje van den Belt, Lonneke JanssenDuijghuijsen, Monic Tomassen, Nicole de Roos, Ben Witteman, Pascale Fança-Berthon, Julie Laval, Nicole de Wit","doi":"10.1017/S0007114526108101","DOIUrl":"https://doi.org/10.1017/S0007114526108101","url":null,"abstract":"Lipopolysaccharide (LPS) has been implicated in increased gut permeability and low-grade mucosal inflammation, conditions that are linked to the pathophysiology of irritable bowel syndrome (IBS). Because increased dietary fat intake can both trigger IBS symptoms and promote LPS translocation in the gut, this study aimed to better understand how a turmeric formula (TF) affects fasting and postprandial LPS response, after a high-fat challenge in patients with IBS (primary outcome). Secondary outcomes included postprandial ApolipoproteinB48 (Apo-B48) and triglycerides (TG) as markers of chylomicron-mediated LPS translocation, as well as gastrointestinal (GI) symptoms and stool pattern. In this randomized, double-blind, placebo-controlled cross-over trial, eighteen patients with IBS completed two high-fat challenge tests after 3-day supplementation with either 300 mg TF or placebo. Blood was collected in the fasting state and up to 5 hours postprandially. Data were analyzed using repeated measures mixed models. TF did not significantly alter postprandial LPS levels compared with placebo but significantly reduced postprandial Apo-B48 and TG (mean ratios 0.82 and 0.87, p=0.04 and p=0.01, respectively). Fasting LPS and TG showed a non-significant reduction after TF (mean ratios 0.79 and 0.87; both p=0.06, respectively). No differences were observed in gastrointestinal symptoms or stool characteristics. To conclude, TF did not influence dietary fat-mediated LPS translocation, but it reduced postprandial chylomicron markers, indicating a potential attenuation of chylomicron-mediated postprandial inflammation. Together with the observed trend towards reduced fasting LPS levels, these findings suggest that TF might have beneficial effects on low-grade subclinical inflammation, which could be relevant for IBS patients.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-28"},"PeriodicalIF":3.1,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of physical activity and dietary quality with stroke: a population-based observational study. 身体活动和饮食质量与中风的关系：一项基于人群的观察性研究。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-08-03 DOI: 10.1017/S0007114526108125

Mu Yang, Shuangfang Fang, Gareth Ambler, Huapin Huang, Yixian Zhang, Huayao Huang, Nan Liu, Houwei Du

{"title":"Association of physical activity and dietary quality with stroke: a population-based observational study.","authors":"Mu Yang, Shuangfang Fang, Gareth Ambler, Huapin Huang, Yixian Zhang, Huayao Huang, Nan Liu, Houwei Du","doi":"10.1017/S0007114526108125","DOIUrl":"10.1017/S0007114526108125","url":null,"abstract":"Little is known about the combined association of physical activity (PA) and dietary quality (DQ) with stroke and its mortality outcomes. This study aims to investigate the individual and combined association of PA and DQ on odds of prevalent stroke and mortality among stroke survivors. We analysed data from 20 225 adults participating in the 2007-2018 National Health and Nutrition Examination Survey, including 838 stroke survivors. PA was measured by the self-reported metabolic equivalent to task (MET) minutes per week and DQ by Healthy Eating Index 2020 (HEI-2020). Logistic regression models evaluated associations with the odds of prevalent stroke, and Cox proportional hazards regression models assessed mortality risks among stroke survivors. Compared with no PA-lower DQ (reference), low PA-lower DQ (adjusted OR 0·49, 95 % CI 0·32-0·75), low PA-higher DQ (adjusted OR 0·56, 95 % CI 0·34-0·92), high PA-lower DQ (adjusted OR 0·66, 95 % CI 0·44-0·99) and high PA-higher DQ (adjusted OR 0·50, 95 % CI 0·34-0·73) were significantly associated with lower odds of stroke. Among stroke survivors, reduced mortality was observed for low PA-higher DQ (adjusted hazard ratio (HR) 0·43; 95 % CI 0·19-0·95), high PA-lower DQ (HR 0·36; 95 % CI 0·17-0·75) and high PA-higher DQ (HR 0·47; 95 % CI 0·27-0·83). This large observational study showed that a combination of appropriate PA and higher DQ is associated with reduced odds of stroke and mortality among stroke survivors. These findings support lifestyle modification as a strategy for stroke prevention and survivor care.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-16"},"PeriodicalIF":3.1,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional roles and nutritional potential of human milk oligosaccharides in swine gut health. 人乳低聚糖在猪肠道健康中的功能作用和营养潜力。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-30 DOI: 10.1017/S0007114526107776

Romaissaa El Bouhi, Qinfeng Hu, Jie Zhong, Pan Zhou, Yong Zhang, Lingbin Liu, Honglin Yan

{"title":"Functional roles and nutritional potential of human milk oligosaccharides in swine gut health.","authors":"Romaissaa El Bouhi, Qinfeng Hu, Jie Zhong, Pan Zhou, Yong Zhang, Lingbin Liu, Honglin Yan","doi":"10.1017/S0007114526107776","DOIUrl":"https://doi.org/10.1017/S0007114526107776","url":null,"abstract":"Human milk oligosaccharides (HMOs) are a prominent class of bioactive glycans recognized for their pivotal roles as prebiotics, anti-adhesive antimicrobials, and immunomodulators in neonatal development. While traditionally studied in the context of infant nutrition, scalable biotechnological production now allows for their evaluation in swine production to address the relatively lower structural complexity of the porcine milk glycome compared to humans. This review critically evaluates the structural diversity and biosynthesis of HMOs, detailing how specific fucosylated and sialylated structures modulate the porcine gut microbiome and reinforce intestinal barrier integrity. We synthesize current evidence regarding the metabolic fate of these glycans in the piglet and address the translational relevance of using swine as high-fidelity models for human gastrointestinal physiology. Furthermore, the review identifies critical knowledge gaps, specifically the lack of large-scale longitudinal studies and comprehensive cost-benefit analyses required to validate the economic feasibility of HMOs in commercial agriculture. By consolidating these mechanistic insights within the context of global efforts to reduce reliance on antibiotic growth promoters, this work underscores the potential of HMOs as precision nutritional tools to enhance resilience and productivity in sustainable animal production systems.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-44"},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cetoleic acid-rich fish oil increases plasma levels of EPA and DHA in healthy volunteers: a double-blinded, randomised, controlled trial. 富含鲸烯酸的鱼油增加健康志愿者血浆中二十碳五烯酸和二十碳五烯酸的水平：一项双盲、随机、对照试验。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-30 DOI: 10.1017/S0007114526107958

Kirsten B Holven, Tuva B Dahl, Pia Bålsrud, Jacob J Christensen, Inger Ottestad, Amanda Rundblad, Bente Ruyter, Sverre Holm, Pål Aukrust, Ylva Schanke, Iselin S Holen, Vibeke H Telle-Hansen, Kjetil Retterstøl, Stine Marie Ulven, Bente E Halvorsen

{"title":"Cetoleic acid-rich fish oil increases plasma levels of EPA and DHA in healthy volunteers: a double-blinded, randomised, controlled trial.","authors":"Kirsten B Holven, Tuva B Dahl, Pia Bålsrud, Jacob J Christensen, Inger Ottestad, Amanda Rundblad, Bente Ruyter, Sverre Holm, Pål Aukrust, Ylva Schanke, Iselin S Holen, Vibeke H Telle-Hansen, Kjetil Retterstøl, Stine Marie Ulven, Bente E Halvorsen","doi":"10.1017/S0007114526107958","DOIUrl":"10.1017/S0007114526107958","url":null,"abstract":"Intake of fish and supplementation with n-3 PUFA are associated with reduced incidence of CVD. Cetoleic acid promotes n-3 PUFA generation in salmon and human HepG2 cells, but data in humans are scarce. To explore the effect of cetoleic acid on n-3 PUFA levels, we performed a double-blinded randomised controlled trial in healthy adults (thirty-seven females and twelve males) for 4 weeks. The participants were randomised to consume either capsules with mackerel oil, naturally rich in cetoleic acid, or a control oil, both with a similar concentration of n-3 PUFA. Supplements with mackerel oil resulted in higher plasma levels of the n-3 PUFA 20:4n-3 (eicosatetraenoic acid) and 20:5n-3 (EPA) as compared with those receiving control oil. In addition, those who received the cetoleic-rich capsules had higher levels of 20:4n-3 in the erythrocytes membrane and a decrease in expression of elongation of very long-chain fatty acids protein 5 in peripheral blood mononuclear cells. We found no differences in lipid, glucose or C-reactive protein between the two treatment groups, consisting of healthy subjects. Our data suggest that supplementation with cetoleic-rich mackerel oil may result in increased levels of certain n-3 PUFA. Further studies should include patients with or at risk for metabolic and CVD.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between chrononutrition behaviours, anthropometric measurements and body composition in adults with prediabetes. 糖尿病前期成人的时间营养行为、人体测量和身体组成之间的关系。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-28 DOI: 10.1017/S0007114526108095

Guey Yong Chong, Kaur Satvinder, Abd Talib Ruzita, See Ling Loy, Hui Yin Tan, Binti Abdullah Rosmiza, Binti Mahmud Hanisah, Woan Yie Siah, Lay Kim Tan, Chee Cheong Kee, Hui Chin Koo

{"title":"Association between chrononutrition behaviours, anthropometric measurements and body composition in adults with prediabetes.","authors":"Guey Yong Chong, Kaur Satvinder, Abd Talib Ruzita, See Ling Loy, Hui Yin Tan, Binti Abdullah Rosmiza, Binti Mahmud Hanisah, Woan Yie Siah, Lay Kim Tan, Chee Cheong Kee, Hui Chin Koo","doi":"10.1017/S0007114526108095","DOIUrl":"10.1017/S0007114526108095","url":null,"abstract":"Delayed eating is associated with a higher risk of overweight and obesity in the general population, but its relationship with anthropometric measurements and body composition in individuals with prediabetes remains unclear. This study investigated the association between chrononutrition behaviours, anthropometric measurements and body composition in adults with prediabetes. This prospective longitudinal study enrolled 120 participants aged 54 ±15 years, who received standard care at healthcare clinics. Socio-demographic data were collected via an interviewer-administered questionnaire. Anthropometric measurements, body composition metrics and chrononutrition behaviours (assessed with the Malay-translated Chrononutrition Profile Questionnaire) were assessed at baseline and 6 months. Multiple linear regression analyses with adjustment for confounders were conducted. A later last meal was associated with higher body weight (β: 0·68 kg, 95 % CI: 0·31, 1·04) and larger waist circumference (β: 1·38 cm, 95 % CI: 0·57, 2·19). Each hour deviation from eating beyond the 07.00-19.00 time window corresponded to an increase in body weight of 1·41 kg (95 % CI: 0·05, 2·77). Increasing frequency of nighttime snacking was associated with higher BMI (β: 1·61 kg/m2, 95 % CI: 0·43, 2·79). Delaying last meal timing (β: 0·44 %, 95 % CI: 0·14, 0·74) and deviating from solar time were associated with higher body fat percentage (β: 1·36 %, 95 % CI: 0·30, 2·42), while increasing frequency of breakfast skipping was associated with lower muscle mass (β: -0·31 kg, 95 % CI: -0·56, 0·07). These findings highlight the importance of chrononutrition behaviours in influencing anthropometric and body composition outcomes, supporting targeted interventions on meal timing in prediabetes management.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary trace element levels in vegans compared with lacto-ovo-vegetarians and omnivores. 纯素食者与乳蛋素食者和杂食者尿液中微量元素水平的比较。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-20 DOI: 10.1017/S0007114526108071

Christian Koeder, Karin B Michels, Alexander Bauer, Lisa Niederreiter, Stefanie Kowarschik, Luciana Hannibal, Roman Huber, Maximilian Andreas Storz

{"title":"Urinary trace element levels in vegans compared with lacto-ovo-vegetarians and omnivores.","authors":"Christian Koeder, Karin B Michels, Alexander Bauer, Lisa Niederreiter, Stefanie Kowarschik, Luciana Hannibal, Roman Huber, Maximilian Andreas Storz","doi":"10.1017/S0007114526108071","DOIUrl":"10.1017/S0007114526108071","url":null,"abstract":"Studies assessing potential differences in trace element status among vegans, lacto-ovo-vegetarians (LOV) and omnivores (OMN) are largely lacking. In this cross-sectional study, urinary levels of twelve elements were analysed in thirty-eight vegans, thirty-seven LOV and forty OMN. After adjustment for covariates, non-creatinine-adjusted As levels were lower in LOV (-54 %) and vegans (-54 %) compared with OMN (P = 0·009). Compared with OMN, vegans (but not LOV) had lower Hg (-48 %; P = 0·028) and higher Cd levels (+42 %; P = 0·023). Other elements (Al, Co, Cu, Pb, Mo, Ni, Tl, Sn and Zn) were similar between groups. Analyses normalised to urinary creatinine confirmed lower As levels in LOV (-63 %) and vegans (-59 %; P < 0·001), but suggested similar Hg and Cd levels in OMN, LOV and vegans, higher Co in LOV (+53 %; P = 0·035) and higher Cu in vegans (+17 %; P = 0·040). Trends (non-significant after adjustment for multiple testing) were noted for Ni (LOV: +119 %), Co (vegans: +43 %) and Zn (vegans: -26 %; compared with OMN). LOV and vegans had similar urinary levels (P ≥ 0·207). Urinary creatinine levels were similar across all groups (P ≥ 0·912). Eight additional elements were not detected (Bi, Au, In, Ir, Pd and Ag) or were detected only in a few samples (Pt and Zr). Overall, LOV and vegans exhibited a lower As burden than OMN. A higher Cd and lower Hg burden in vegans were not confirmed in creatinine-adjusted analyses. Similar studies are warranted to validate results. Biomonitoring studies may benefit from considering vegetarian status, particularly for As exposure.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of phytosterol-enriched corn-wheat germ blended oil on immune markers and T-cell subsets in Chinese adults with dyslipidaemia: a secondary analysis of a randomised controlled trial. 富含植物甾醇的玉米-小麦胚芽混合油对中国成人血脂异常患者免疫标记物和t细胞亚群的影响：一项随机对照试验的二次分析

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-17 DOI: 10.1017/S0007114526108083

Sikai Dong, Jiayue Xia, Zhiwen Zhang, Tianyu Wu, Rui Zhang, Zhi He, Guo-Fang Shu, Zhiyuan Feng, Junhui Yu, Jiongnan Wang, Shiyu Yin, Ligang Yang, Wang Liao, Hui Xia, Shaokang Wang, Da Pan, Guiju Sun

{"title":"Effects of phytosterol-enriched corn-wheat germ blended oil on immune markers and T-cell subsets in Chinese adults with dyslipidaemia: a secondary analysis of a randomised controlled trial.","authors":"Sikai Dong, Jiayue Xia, Zhiwen Zhang, Tianyu Wu, Rui Zhang, Zhi He, Guo-Fang Shu, Zhiyuan Feng, Junhui Yu, Jiongnan Wang, Shiyu Yin, Ligang Yang, Wang Liao, Hui Xia, Shaokang Wang, Da Pan, Guiju Sun","doi":"10.1017/S0007114526108083","DOIUrl":"10.1017/S0007114526108083","url":null,"abstract":"Dyslipidaemia is associated with chronic low-grade inflammation and immune dysfunction, but the immunological effects of dietary phytosterols in humans remain unclear. We conducted a secondary analysis of an outcome-assessor-blinded, randomised controlled feeding trial to evaluate the effects of a high-phytosterol (HPS) diet, using phytosterol-enriched corn-wheat germ blended oil (CWGO), compared with a low-phytosterol (LPS) diet using peanut oil, on systemic inflammatory markers, humoural immune markers and peripheral blood lymphocyte subsets in Chinese adults with dyslipidaemia. After a 2-week run-in period, 104 participants were randomised to the HPS group (n 52) or the LPS group (n 52) for 12 weeks. In intention-to-treat analyses, the HPS group had a higher CD4+:CD8+ ratio at 12 weeks than the LPS group (adjusted mean difference: 0·561; 95 % CI 0·060, 1·063; P = 0·03) and a lower CD8+ T-cell count (adjusted mean difference: -116·315 cells/μl; 95 % CI -215·781, -16·849; P = 0·02). No significant between-group differences were observed for systemic inflammatory markers, humoral immune markers or most other lymphocyte subset outcomes. In per-protocol analyses, the difference in CD4+:CD8+ ratio remained significant, whereas the reduction in CD8+ T-cell count was attenuated. These exploratory findings suggest that a 12-week phytosterol-enriched CWGO intervention may be associated with changes in T-cell subset balance in adults with dyslipidaemia, although the results should be interpreted cautiously given the exploratory nature of this secondary analysis.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-13"},"PeriodicalIF":3.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary acid load and incident diabetes risk among Japanese adults: findings from the Japan Collaborative Cohort Study. 日本成年人膳食酸负荷与糖尿病发病风险之间的关系：来自日本合作队列研究的发现

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-17 DOI: 10.1017/S000711452610806X

Satoshi Sunohara, Akinori Yaegashi, Hana Wakasa, Takashi Kimura, Akiko Tamakoshi

{"title":"Association between dietary acid load and incident diabetes risk among Japanese adults: findings from the Japan Collaborative Cohort Study.","authors":"Satoshi Sunohara, Akinori Yaegashi, Hana Wakasa, Takashi Kimura, Akiko Tamakoshi","doi":"10.1017/S000711452610806X","DOIUrl":"10.1017/S000711452610806X","url":null,"abstract":"Dietary acid load (DAL), which reflects diet's overall acid-base balance, has been proposed to influence glucose metabolism; however, epidemiological findings on its relationship with diabetes risk remain inconsistent. While Western studies suggest that higher DAL is associated with higher diabetes risk, particularly among women, findings from East Asian populations have been inconsistent, particularly regarding sex-specific associations. The present prospective study examined the association between DAL and 5-year diabetes incidence among Japanese adults, focusing on sex-specific differences. Data were obtained from 19 040 participants (7037 men and 12 003 women) in the Japan Collaborative Cohort Study. DAL was estimated based on the potential renal acid load (PRAL) and net endogenous acid production (NEAP) derived from a validated food-frequency questionnaire. Odds ratios and 95 % confidence intervals for incident diabetes were estimated separately for men and women across PRAL and NEAP quartiles using multivariable logistic regression with multiple imputations for missing covariates. During follow-up, 490 new diabetes cases were identified (245 in each sex). Among women, higher DAL was significantly associated with a higher risk of diabetes; OR (95 % CI) from multivariable-adjusted model, including socio-demographic, lifestyle, health status and macronutrient covariates, comparing the highest with the lowest quartiles were 1·61 (1·09, 2·37) for PRAL and 1·72 (1·18, 2·52) for NEAP. No clear associations were observed among men. The findings provide a foundation for further studies in East Asian populations using more precise dietary assessment methods to clarify the association between DAL and incident diabetes and to inform dietary guidelines and preventive strategies.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-9"},"PeriodicalIF":3.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148469234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between breakfast frequency, forced vital capacity and psychological symptoms: a cross-sectional study of Chinese adolescents. 早餐频率、肺活量和心理症状之间的关系：中国青少年的横断面研究。

IF 3.1 3区医学

British Journal of Nutrition Pub Date : 2026-07-16 DOI: 10.1017/S0007114526108046

Jian Dong, Cunjian Bi, Mengmeng Zhang, Tianyu Zhou, Min Zhang

{"title":"Association between breakfast frequency, forced vital capacity and psychological symptoms: a cross-sectional study of Chinese adolescents.","authors":"Jian Dong, Cunjian Bi, Mengmeng Zhang, Tianyu Zhou, Min Zhang","doi":"10.1017/S0007114526108046","DOIUrl":"10.1017/S0007114526108046","url":null,"abstract":"This cross-sectional study examined the independent and combined associations of breakfast frequency, forced vital capacity (FVC) and psychological symptoms among Chinese adolescents. A total of 2776 adolescents aged 12-17 years were recruited from three regions of Anhui Province using stratified cluster random sampling. Breakfast frequency was self-reported as days per week over the past month and categorised as low, medium or high. FVC was measured with a standardised electronic spirometer (CSTF-FH) following CNSSCH (Chinese National Student Physical Fitness Survey) protocols. Psychological symptoms were assessed using the Multidimensional Subhealth Assessment Questionnaire for Adolescents (MSQA) and dichotomised according to established cut-offs. Covariates included age, height, weight, grip strength, standing long jump, sleep duration and parental education. Binary logistic regression was used, building three models. The overall prevalence of psychological symptoms was 14 %. Breakfast frequency was inversely correlated with psychological symptoms (P < 0·001). Low breakfast frequency (1-2 d/week) was associated with a higher symptom rate (31 %) than high frequency (5-7 d/week, 12 %) and increased odds of symptoms (OR = 3·34, 95 % CI 2·04, 5·60). No independent association was found between FVC and psychological symptoms. However, adolescents with both low breakfast frequency and low FVC had 4·10 times higher odds of psychological symptoms (95 % CI 1·83, 9·21, P < 0·001) than those with high breakfast frequency and high FVC. These findings suggest that low breakfast frequency is a robust correlate of psychological symptoms in adolescents, and that the combination of low breakfast frequency with low FVC identifies a particularly high-risk group.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-11"},"PeriodicalIF":3.1,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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