Megan Turner, Deborah N Ashtree, Melissa M Lane, Kim Anastasiou, Michalis Hadjikakou, Samantha L Dawson, Mark Lawrence, Laura Jennings, Ozge Geyik, Felice N Jacka, Vincent L Versace, Mary Lou Chatterton, Pilvikki Absetz, Marita Bryan, Barbara Brayner, Sophie Mahoney, Dean Saunders, Tayla John, Lauren M Young, Adrienne O'Neil
{"title":"Environmental co-benefits of a Mediterranean-style dietary intervention for reducing depressive symptoms in adults: results from the Curbing Anxiety and Depression using Lifestyle Medicine randomised controlled trial.","authors":"Megan Turner, Deborah N Ashtree, Melissa M Lane, Kim Anastasiou, Michalis Hadjikakou, Samantha L Dawson, Mark Lawrence, Laura Jennings, Ozge Geyik, Felice N Jacka, Vincent L Versace, Mary Lou Chatterton, Pilvikki Absetz, Marita Bryan, Barbara Brayner, Sophie Mahoney, Dean Saunders, Tayla John, Lauren M Young, Adrienne O'Neil","doi":"10.1017/S0007114525103942","DOIUrl":"10.1017/S0007114525103942","url":null,"abstract":"<p><p>This study explored whether lifestyle therapy that promoted adherence to a Mediterranean-style diet as a treatment for depression led to environmental co-benefits. Participants (<i>n</i> 75 complete case) were Australian adults in the Curbing Anxiety and Depression using Lifestyle Medicine non-inferiority, randomised controlled trial, which showed that lifestyle therapy was non-inferior to psychotherapy in reducing depressive symptoms, when delivered in group format via video conferencing over an 8-week treatment period. In this secondary analysis, we hypothesised that the lifestyle arm would be superior to the psychotherapy arm in reducing the environmental impact of self-reported diet over time. Dietary intake derived from FFQ at baseline and 8 weeks was transformed into environmental impact scores by calculating global warming potential (GWP)*. GWP* was calculated for total dietary intake and distinct food groups (Australian Dietary Guidelines and NOVA classifications). Within-arm changes in GWP* over time were calculated using the median difference. Neither arm showed significant changes. Between-arm differences in percentage change in GWP* scores over time were analysed using generalised estimating equations models. No between-arm difference for total GWP* score was found (<i>β</i> = 11·06 (-7·04, 29·15)). When examining distinct food groups, results were mixed. These novel findings contribute to the sparse evidence base that has measured the environmental impact of diets in a clinical trial context. Whilst lifestyle therapy that reduced depressive symptoms did not have clear environmental benefits relative to psychotherapy, nutritional counselling that focuses on the environmental impact of food choices may drive more pronounced planetary co-benefits.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"115-123"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karishma Hosein, Taniya S Nagpal, Roberta Bgeginski, Harry Prapavessis, Isabelle Giroux, Michelle F Mottola
{"title":"A cross-sectional comparison of the functionality of the short-form FFQ to a 3-day food intake record completed early in the second trimester of pregnancy.","authors":"Karishma Hosein, Taniya S Nagpal, Roberta Bgeginski, Harry Prapavessis, Isabelle Giroux, Michelle F Mottola","doi":"10.1017/S0007114525103966","DOIUrl":"10.1017/S0007114525103966","url":null,"abstract":"<p><p>Using a behavioural intervention to target nutrition during pregnancy may be key in meeting recommendations for healthy eating. The aim was to assess the use of a short-term dietary intake measurement tool (3-day food intake record) to infer long-term habitual dietary intake during pregnancy (using a short-form FFQ). A convenience sample (<i>n</i> 90) between 12- and 18-weeks' gestation was recruited from a larger randomised controlled trial for cross-sectional analysis. Participants completed a forty-four-item FFQ and 3-day food intake record. Using the participant food intake record, the investigator blindly completed a second frequency questionnaire. The frequency questionnaires were scored using dietary quality scores (DQS) and compared. Aggregate data were evaluated using a Wilcoxon signed rank test, and individual-level data were evaluated using a Bland-Altman plot. No significant difference was observed in the scores (<i>Z</i> = -1·88, <i>P</i> = 0·06), with small effect size (<i>r</i>= 0·19). The Bland-Altman plot showed that comparing the DQS derived from the two different dietary assessments underestimated scores by a mean difference of 0·4 points (95 % limits of agreement: -3·50 to 4·26). The data points were evenly spread suggesting no systematic variation for over- or underestimation of scores. Minimal difference was observed between the functionality of the two assessment instruments. However, the food intake record can be completed by pregnant individuals to estimate short-term nutrient intake and then scored by the investigator to estimate long-term dietary quality. Combining these two instruments may best capture the most accurate representation of dietary habits over time.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"156-160"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inverse association between fruit juice consumption and type 2 diabetes among individuals with high genetic risk on type 2 diabetes: the Japan Multi-Institutional Collaborative Cohort (J-MICC) study.","authors":"Tomoki Kawahara, Nobutoshi Nawa, Isao Oze, Hiroaki Ikezaki, Megumi Hara, Yoko Kubo, Mako Nagayoshi, Hidemi Ito, Nobuaki Michihata, Rie Ibusuki, Sadao Suzuki, Etusko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Sakurako Katsuura-Kamano, Masahiro Nakatochi, Yukihide Momozawa, Takashi Tamura, Takeo Fujiwara, Keitaro Matsuo","doi":"10.1017/S0007114525103863","DOIUrl":"10.1017/S0007114525103863","url":null,"abstract":"<p><p>Previous studies on the association between fruit juice consumption and type 2 diabetes remain controversial, which might be due to heterogeneity in the polygenic risk score (PRS) for type 2 diabetes. We examined the association between fruit juice and type 2 diabetes by PRS for type 2 diabetes. We investigated whether fruit juice influences type 2 diabetes risk differently among individuals with varying genetic risks. Data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, a cross-sectional study of 13 769 Japanese individuals was used for our analysis. The primary exposure was the frequency of fruit juice, categorised as do not drink, less than 1 cup per day or more than 1 cup per day. We selected PGS002379, a PRS for type 2 diabetes developed using East Asian populations. The primary outcome was physician-diagnosed type 2 diabetes, reported by participants. The consumption of fruit juice was significantly inversely associated with type 2 diabetes in the group with a high PRS for type 2 diabetes (OR: 0·78, 95 % CI: 0·65, 0·93 for < 1 cup/d and OR: 0·54, 95 % CI: 0·30, 0·96 for > 1/d), but this association was not observed in the low PRS group. Fruit juice consumption was inversely associated with type 2 diabetes, especially in genetically high-risk populations for type 2 diabetes.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"89-96"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coverage of vitamin A supplementation among under-five children in India and its relationship with childhood mortality: insights from multiple rounds of a nationally representative survey from 2005-2006 to 2019-2021.","authors":"Trishna Bora, Kaustubh Bora","doi":"10.1017/S0007114525104017","DOIUrl":"10.1017/S0007114525104017","url":null,"abstract":"<p><p>We investigated the coverage of childhood vitamin A supplementation (VAS) across India from 2005-2006 to 2019-2021 and further explored how it related to childhood mortality. Data collected from mothers through standard questionnaires during the latest three rounds of the National Family Health Survey (2005-2006, 2015-2016 and 2019-2021) were used. Information on VAS in children aged 9-35 months was available from 2015-2016 to 2019-2021. Information on VAS among children aged 9-59 months was available from 2005-2006 to 2015-2016. Childhood VAS coverage was determined nationally and subnationally (viz. individual states, geography, socio-demographic index and developmental groups). Nearly 40 % eligible children aged 9-59 months and 30 % eligible children aged 9-35 months missed VAS during recent times. But improvements in VAS coverage were noticed over the years: from 18·6 % (2005-2006) to 60·5 % (2015-2016) among children aged 9-59 months and from 64·5 % (2015-2016) to 71·2 % (2019-2021) among children aged 9-35 months. There were coverage disparities, with Western India documenting the highest and Northeastern India documenting the lowest coverage values. During simple linear regression analysis, childhood mortality between 1 and 5 years of age varied inversely as a function of VAS coverage among children aged 9-59 months, with the association being less pronounced in 2015-2016 (<i>β</i> = -0·47) than in 2005-2006 (<i>β</i> = -0·40). However, this relationship disappeared when we accounted for potential confounders (viz. childhood immunisation and socio-economic factors) through multivariate analysis, suggesting that the role of VAS in promoting childhood survival may be limited during present times.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"161-168"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fusta Azupogo, Karin J Borgonjen-van den Berg, Richmond Aryeetey, Inge D Brouwer
{"title":"Nutrient gaps and dietary adequacy among adolescent girls in rural North-Eastern Ghana: the role of local food-based approaches, school lunch and multiple-micronutrient fortified biscuits.","authors":"Fusta Azupogo, Karin J Borgonjen-van den Berg, Richmond Aryeetey, Inge D Brouwer","doi":"10.1017/S0007114525103929","DOIUrl":"10.1017/S0007114525103929","url":null,"abstract":"<p><p>A local food-based approach, including school lunch with multiple-micronutrient fortified biscuits (MMB) as supplementary snacks, may enhance dietary adequacy, although current evidence remains limited. This study assessed nutrient inadequacies and developed food-based dietary recommendations (FBR) incorporating school lunch from the Ghana School Feeding Programme (GSFP) and MMB. Data from 292 girls aged 10-17 years, enrolled in the Ten2Twenty-Ghana study was analysed. Dietary intake was assessed via a quantitative 24-h dietary recall. Usual intakes were estimated using the National Cancer Institute method. Linear programming with Optifood was used to develop FBRs based on commonly consumed foods (≥5% of participants) and their median serving sizes, intake frequency, nutrient content, and cost per 100 g. Constraints included estimated energy needs and harmonised average nutrient requirements. The mean usual energy intake was 2351 (sd 66) kcal/d. Ca (99·8 %), vitamin B<sub>12</sub> (99·8 %), riboflavin (96·2 %), vitamin A (91·5 %), vitamin C (87·6 %), Fe (73·7 %), folate (49·3 %) and Zn (8·5 %) inadequacies were prevalent. Optimised diets achieved adequacy for protein and most micronutrients, except Ca and vitamin B<sub>12</sub>, besides vitamin A for 15-17-year-old girls. School lunch from the GSFP did not enhance micronutrient levels when added to the daily diet. Adding MMB to the daily diet ensured adequacy for vitamin C, riboflavin and Fe, although marginal for Fe. Ca and vitamin A improved substantially with MMB for girls aged 15-17 but remained below the harmonised average requirements. Integrating regular school lunch with specialised fortified foods may be a cost-effective strategy to enhance dietary adequacy for adolescent girls in rural areas.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"134-146"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of vitamin D supplementation for major adverse cardiovascular events: a meta-analysis based on randomised controlled trials.","authors":"Xiaoqing Cheng, Zhenghao Chen, Yingying Fang, Qiufeng Zhang, Bangsheng Chen, Wang Xi, Ziqiao Pan, Luyong Guo","doi":"10.1017/S0007114525103954","DOIUrl":"10.1017/S0007114525103954","url":null,"abstract":"<p><p>This meta-analysis assesses the relationship between vitamin D supplementation and incidence of major adverse cardiovascular events (MACE). PubMed, Web of science, Ovid, Cochrane Library and Clinical Trials were used to systematically search from their inception until July 2024. Hazard ratios (HR) and 95 % CI were employed to assess the association between vitamin D supplementation and MACE. This analysis included five randomised controlled trials (RCT). Pooled results showed no significant difference in the incidence of MACE (HR: 0·96; <i>P</i> = 0·77) and expanded MACE (HR: 0·96; <i>P</i> = 0·77) between the vitamin D intervention group and the control group. Further, the vitamin D intervention group had a lower incidence of myocardial infarction (MI), but the difference was not statistically significant (HR: 0·88, 95 % CI: 0·77, 1·01; <i>P</i> = 0·061); nevertheless, vitamin D supplementation had no effect on the reduced incidence of stroke (<i>P</i> = 0·675) or cardiovascular death (<i>P</i> = 0·422). Among males (<i>P</i> = 0·109) and females (<i>P</i> = 0·468), vitamin D supplementation had no effect on the reduced incidence of MACE. For participants with a BMI < 25 kg/m<sup>2</sup>, the difference was not statistically significant (<i>P</i> = 0·782); notably, the vitamin D intervention group had a lower incidence of MACE for those with BMI ≥ 25 kg/m<sup>2</sup> (HR: 0·91, 95 % CI: 0·83, 1·00; <i>P</i> = 0·055). Vitamin D supplementation did not significantly contribute to the risk reduction of MACE, stroke and cardiovascular death in the general population, but may be helpful for MI. Notably, the effect of vitamin D supplementation for MACE was influenced by BMI. Overweight/obese people should be advised to take vitamin D to reduce the incidence of MACE.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"124-133"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liangyu Yin, Ning Tong, Na Li, Jie Liu, Wei Li, Jiuwei Cui, Zengqing Guo, Qinghua Yao, Fuxiang Zhou, Ming Liu, Zhikang Chen, Huiqing Yu, Tao Li, Zengning Li, Pingping Jia, Chunhua Song, Hongxia Xu, Hanping Shi
{"title":"Explainable deep learning model WAL-net for individualised assessment of potentially reversible malnutrition in patients with cancer: a multicentre cohort study.","authors":"Liangyu Yin, Ning Tong, Na Li, Jie Liu, Wei Li, Jiuwei Cui, Zengqing Guo, Qinghua Yao, Fuxiang Zhou, Ming Liu, Zhikang Chen, Huiqing Yu, Tao Li, Zengning Li, Pingping Jia, Chunhua Song, Hongxia Xu, Hanping Shi","doi":"10.1017/S000711452510384X","DOIUrl":"10.1017/S000711452510384X","url":null,"abstract":"<p><p>Persistent malnutrition is associated with poor clinical outcomes in cancer. However, assessing its reversibility can be challenging. The present study aimed to utilise machine learning (ML) to predict reversible malnutrition (RM) in patients with cancer. A multicentre cohort study including hospitalised oncology patients. Malnutrition was diagnosed using an international consensus. RM was defined as a positive diagnosis of malnutrition upon patient admission which turned negative one month later. Time-series data on body weight and skeletal muscle were modelled using a long short-term memory architecture to predict RM. The model was named as WAL-net, and its performance, explainability, clinical relevance and generalisability were evaluated. We investigated 4254 patients with cancer-associated malnutrition (discovery set = 2977, test set = 1277). There were 2783 men and 1471 women (median age = 61 years). RM was identified in 754 (17·7 %) patients. RM/non-RM groups showed distinct patterns of weight and muscle dynamics, and RM was negatively correlated to the progressive stages of cancer cachexia (<i>r</i> = -0·340, <i>P</i> < 0·001). WAL-net was the state-of-the-art model among all ML algorithms evaluated, demonstrating favourable performance to predict RM in the test set (AUC = 0·924, 95 % CI = 0·904, 0·944) and an external validation set (<i>n</i> 798, AUC = 0·909, 95 % CI = 0·876, 0·943). Model-predicted RM using baseline information was associated with lower future risks of underweight, sarcopenia, performance status decline and progression of malnutrition (all <i>P</i> < 0·05). This study presents an explainable deep learning model, the WAL-net, for early identification of RM in patients with cancer. These findings might help the management of cancer-associated malnutrition to optimise patient outcomes in multidisciplinary cancer care.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"97-114"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autoimmune thyroid diseases, Celiac disease and Gluten-free diet: a Mendelian randomization study.","authors":"Yue-Heng Pu, Cai-Yi Long, Ren-Song Yue, Bo-Xun Zhang, Ya-Yi Jiang, Zi-Han Li","doi":"10.1017/S0007114525103917","DOIUrl":"https://doi.org/10.1017/S0007114525103917","url":null,"abstract":"<p><p>Previous studies have reported comorbidities of autoimmune thyroid disorders (AITD), including Hashimoto's disease (HT) and Graves' disease (GD), and celiac disease (CeD), as well as the possible beneficial effects of a gluten-free diet (GFD) on AITD. Nonetheless, it remains uncertain whether there is a genetic causal relationship between AITD and CeD, while the beneficial effects on a GFD are controversial. This study aim to explore the causal relationship between CeD and AITD, particularly with HT, and to determine whether a GFD is beneficial for AITD. We performed a two-sample Mendelian Randomization (MR) analysis on data from the largest meta-analysis summary statistics of AITD, CeD and GFD. Genetic instrumental variables were established by pinpointing single nucleotide polymorphisms (SNPs) that relate to corresponding factors. In assessing sensitivity and heterogeneity, we conducted examinations of MR Egger, weighted median, simple mode, weighted mode, and MR Egger intercept tests. HT was found to play a pathogenic role in increasing the risk of CeD (OR<sub>IVW</sub> = 1.544 [95%CI 1.153-2.068], <i>p</i> = 0.00355), and our Mendelian randomization study does not support genetic liability related to CeD with GD (Graves' disease) and GFD with AITD. This study supports the positive correlation between HT risk and CeD risk, while GFD has no protective effect on AITD and may exert its effect through other mechanisms. These findings provide valuable insights into potential targets for disease intervention and treatment at the genetic level.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-27"},"PeriodicalIF":3.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Misko Milev, Boris Roglev, Maria Kondeva Rogleva, Milena Georgieva, George Miloshev, Tatjana Ruskovska
{"title":"Impact of (poly)phenol-rich dietary sources on DNA damage: insights from human intervention studies using the Comet assay - a review and perspective.","authors":"Misko Milev, Boris Roglev, Maria Kondeva Rogleva, Milena Georgieva, George Miloshev, Tatjana Ruskovska","doi":"10.1017/S000711452500073X","DOIUrl":"10.1017/S000711452500073X","url":null,"abstract":"<p><p>(Poly)phenols are plant-derived food bioactives abundantly present in human diet. They exert positive effects on various aspects of human health and in particular in reducing the risk of chronic non-communicable diseases. Dietary (poly)phenols have been reported to improve vascular function, blood lipids, insulin sensitivity and to decrease systemic inflammation. Evidence also suggests that (poly)phenols may exert protective effects on DNA, by reducing the extent of its damage. In recent years, advanced analytical methods, including transcriptomics, metabolomics, proteomics and metagenomics, have been employed to unravel the complex impact of (poly)phenols in health and disease. Advances in bioinformatics enable an integrated multi-omics approach to data analysis, opening avenues for discovering new, previously unknown molecular mechanisms of action. Innovative solutions and automation of the Comet assay offer new opportunities for more in-depth analysis of the impact of (poly)phenols on DNA damage and its inclusion in integrative bioinformatic models. Such an approach has the potential to uncover new multi-level interactions and to reveal previously unknown factors underlying inter-individual variabilities in health-promoting effects of (poly)phenols. This review provides an insight into the application of the Comet assay in human intervention studies using (poly)phenol-rich dietary sources. Recent advancements in the Comet assay technology and the prospects for more extensive use of this method in future human intervention studies with (poly)phenols could contribute to the development of personalized dietary recommendations for these plant-derived food bioactives.</p>","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}