British Journal of Nutrition最新文献_第9页

Associations between inflammation-related dietary patterns and obesity: A cohort study among Tibetan adults.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-24 DOI: 10.1017/S0007114524003337

Xiaomin Sun, Wenxiu Jian, Xiao Tang, Rui Li, Bin Zhang, Yingxin Chen, Haijing Wang, Lei Zhao, Yangrui Zhang, Tanisawa Kumpei, Zumin Shi, Youfa Wang, Wen Peng

{"title":"Associations between inflammation-related dietary patterns and obesity: A cohort study among Tibetan adults.","authors":"Xiaomin Sun, Wenxiu Jian, Xiao Tang, Rui Li, Bin Zhang, Yingxin Chen, Haijing Wang, Lei Zhao, Yangrui Zhang, Tanisawa Kumpei, Zumin Shi, Youfa Wang, Wen Peng","doi":"10.1017/S0007114524003337","DOIUrl":"https://doi.org/10.1017/S0007114524003337","url":null,"abstract":"Substantial changes resulting from the interaction of environmental and dietary factors contribute to an increased risk of obesity, while their specific associations with obesity remain unclear. Identify inflammation-related dietary patterns (DPs) and explore their associations with obesity among urbanized Tibetan adults under significant environmental and dietary changes.Totally, 1826 subjects from the suburbs of Golmud City were enrolled in an open cohort study, of which 514 were followed up. Height, weight, and waist circumference were used to define overweight and obesity. DPs were derived using reduced rank regression with 41 food groups as predictors and hs-CRP and prognostic nutritional index as inflammatory response variables. Altitude was classified as high or ultra-high. Two DPs were extracted. DP-1 was characterized by having high consumptions of sugar-sweetened beverages, savory snacks, and poultry, and a low intake of tsamba. DP-2 had high intakes of poultry, pork, animal offal, and fruits, and a low intake of butter tea. Participants in the highest tertiles (T3) of DPs had increased risks of overweight and obesity (DP-1: OR=1.37, 95% CI: 1.07, 1.77; DP-2: OR=1.48, 95% CI: 1.18, 1.85) than those in the lowest tertiles (T1). Participants in T3 of DP-2 had an increased risk of central obesity (OR=2.25, 95% CI: 1.49, 3.39) than those in T1. The positive association of DP-1 with overweight and obesity was only significant at high altitudes, while no similar effect was observed for DP-2. Inflammation-related DPs were associated with increased risks of overweight and/or obesity.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-26"},"PeriodicalIF":3.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of seven-strain probiotic supplementation on cell adhesion molecules, oxidative stress, and antioxidant parameters in patients with traumatic brain injury: a randomized controlled clinical trial.

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-23 DOI: 10.1017/S0007114524003234

Nooshin Noshadi, Seyedeh Sana Sabet, Sarvin Sanaie, Ata Mahmoodpoor, Helda Tutunchi, Sina Naghshi, Seyed Rafie Arefhosseini, Mehrangiz Ebrahimi-Mameghani

{"title":"The effects of seven-strain probiotic supplementation on cell adhesion molecules, oxidative stress, and antioxidant parameters in patients with traumatic brain injury: a randomized controlled clinical trial.","authors":"Nooshin Noshadi, Seyedeh Sana Sabet, Sarvin Sanaie, Ata Mahmoodpoor, Helda Tutunchi, Sina Naghshi, Seyed Rafie Arefhosseini, Mehrangiz Ebrahimi-Mameghani","doi":"10.1017/S0007114524003234","DOIUrl":"https://doi.org/10.1017/S0007114524003234","url":null,"abstract":"The therapeutic effects of probiotics in patients with traumatic brain injury (TBI) remain unclear. This study aimed to investigate the effects of probiotic supplementation on cell adhesion molecules, oxidative stress, and antioxidant parameters in TBI patients. This randomized, double-blind, placebo-controlled trial included 46 TBI patients who were randomly assigned to receive either a probiotic supplement (n = 23) or a placebo (n = 23) for 14 days. The probiotic capsule contained four strains of Lactobacillus (L. casei, L. bulgaricus, L. rhamnosus, L. acidophilus), two strains of Bifidobacterium (B. longum, B. breve), and Streptococcus thermophilus. Serum levels of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, pro-oxidant antioxidant balance (PAB), malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC), and arylesterase (ARE) activity were measured at the beginning and end of the trial. Dietary intakes of patients were also recorded at the beginning and end of the trial. At the end of the study, there were no significant changes in ICAM-1, VCAM-1, PAB, MDA, NO, TAC, and ARE levels. However, patients who received probiotic supplements had significantly increased dietary intakes of energy, macronutrients, vitamin E, zinc, copper, and selenium compared with the placebo group. This study provides evidence that probiotic supplementation for 14 days in TBI patients has beneficial effects on dietary intake. However, it did not affect serum levels of cell adhesion molecules, oxidative stress, or antioxidant parameters. These findings should be considered preliminary, and further research is needed to evaluate long-term and clinical outcomes.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-25"},"PeriodicalIF":3.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The development and evaluation of multiple regression equations based on four common nutritional analysis packages to predict the metabolisable energy density of diets fed to grower/finisher and adult pigs and their use for rat and mouse diets. 基于4种常用营养分析软件包建立多元回归方程并进行评价，以预测生长/育肥猪和成年猪饲粮的代谢能密度及其在大鼠和小鼠饲粮中的应用。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-17 DOI: 10.1017/S0007114525000042

Graham Tobin, Annette Schuhmacher, Tomasz Górecki, Łukasz Smaga

{"title":"The development and evaluation of multiple regression equations based on four common nutritional analysis packages to predict the metabolisable energy density of diets fed to grower/finisher and adult pigs and their use for rat and mouse diets.","authors":"Graham Tobin, Annette Schuhmacher, Tomasz Górecki, Łukasz Smaga","doi":"10.1017/S0007114525000042","DOIUrl":"10.1017/S0007114525000042","url":null,"abstract":"We have used multiple regression analyses to develop a series of metabolisable energy prediction equations from chemical analyses of pig diets that can be extended to murine diets. We compiled four datasets from an extensive range of published metabolism studies with grower/finisher and adult pigs. The analytes in the datasets were increasingly complex, comprising (1) the proximate or Weende analysis, (2) the previous analysis but with neutral detergent fibre replacing crude fibre, (3) the neutral detergent fibre package plus starch and (4) the neutral detergent fibre package plus starch and sugars. Diet manufacturers routinely provide most of the analytes for batches of murine diet, or they are easily obtainable. The study uniquely compares the four analytical packages side by side. The number of records in the datasets varies from 367 to 827. With increasing analytical complexity, adjusted R2 values for metabolisable energy prediction improved from 0·751 to 0·869 and the mean absolute error from 0·422 to 0·289 kJ/g. Overall, the models' prediction interval improved from 1 to 0·7 kJ/g, which is ± 7 to 5 % for a typical dietary metabolisable energy density of 14·8 kJ/g. Although prediction accuracy increases as one extends the range and complexity of the analytes measured, the improvement is slight and may not justify the substantial increase in analytical cost. The equations were validated for use on future datasets by k-fold analysis. Although the equations are developed from pig data, they are suitable for rat and mouse diets, based on comparable digestibility measurements, and substantially improve existing methods.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-23"},"PeriodicalIF":3.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor: response to 'Meat Intake and Type 2 Diabetes among Japanese Workers' published online in British Journal of Nutrition on 23 September 2024. 致编辑的信：对“日本工人的肉类摄入与2型糖尿病”的回应，发表在2024年9月23日的英国《营养》杂志上。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-17 DOI: 10.1017/S0007114524003118

Shawn Joseph, Sheena Christy

引用次数: 0

Population attributable fractions for risk factors for childhood anaemia: Findings from the 2017 Togo Malaria Indicator Survey. 儿童贫血危险因素的人口归因分数：2017年多哥疟疾指标调查结果

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-16 DOI: 10.1017/S0007114524003313

Phyllis Ohene-Agyei, Aude Laetitia Ndoadoumgue, Essossimna Bana-Ewai, Issifou Yaya, Aboubakari Nambiema

{"title":"Population attributable fractions for risk factors for childhood anaemia: Findings from the 2017 Togo Malaria Indicator Survey.","authors":"Phyllis Ohene-Agyei, Aude Laetitia Ndoadoumgue, Essossimna Bana-Ewai, Issifou Yaya, Aboubakari Nambiema","doi":"10.1017/S0007114524003313","DOIUrl":"https://doi.org/10.1017/S0007114524003313","url":null,"abstract":"Anaemia continues to be a major public health challenge in developing countries, particularly in Sub-Saharan Africa. This study estimated the proportion of anaemia cases that could be potentially prevented among children aged 6-59 months in Togo. Data from the 2017 national Malaria Indicator survey in Togo, the last one conducted to date, was used for this study. Maternal, child and household data were collected using a standard questionnaire administered face-to-face by trained interviewers. Haemoglobin tests were conducted for children and their mothers. A total of 2796 children were included in the analyses. The prevalence of anaemia was 75.0% (95% confidence interval, CI: 72.5-88.0). Factors associated with childhood anaemia were: age [(adjusted prevalence ratio, aPR=1.46 (CI: 1.37-1.56) for 6-23 months and aPR=1.23 (1.14-1.32) for 24-42 months, ref: 43-59 months], a later birth order (≥4th position) [aPR=1.11 (1.03-1.19), ref: 1st-2nd position], malaria in children [aPR=1.30 (1.22-1.38)], maternal age ≤25 [aPR=1.17 (1.08-1.27), ref: ≥35 years], maternal anaemia [aPR=1.13 (1.07-1.19)], lack of maternal education [aPR=1.10 (1.02-1.18), ref: ≥secondary], number of children under 5 in household [aPR=1.07 (1.00-1.14) for ≥3, ref: 0-1], unimproved sanitation facilities [aPR=1.12 (1.02-1.22)] and low/middle household incomes [aPR=1.16 (1.04-1.30) and aPR=1.13 (1.01-1.26), respectively, ref: high]. The population-attributable fraction was estimated at 8.2% (6.3-10.1%) for child-related modifiable factors, 11.1% (5.7-16.3%) for maternal-related factors, 15.8% (8.6-22.5%) for household-related factors, and 30.9% (24.0-37.2%) for the combination of all modifiable factors. This study highlighted a high prevalence of childhood anaemia in Togo and showed that a high proportion of this could be prevented.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-27"},"PeriodicalIF":3.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between skeletal muscle mass and elevated blood pressure are independent of body fat: a cross-sectional study in young adult women of African ancestry. 骨骼肌质量和血压升高之间的关联与体脂无关：一项针对非洲裔年轻成年女性的横断面研究。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-16 DOI: 10.1017/S0007114525000029

Siphiwe N Dlamini, Shane A Norris, Lisa K Micklesfield

{"title":"Associations between skeletal muscle mass and elevated blood pressure are independent of body fat: a cross-sectional study in young adult women of African ancestry.","authors":"Siphiwe N Dlamini, Shane A Norris, Lisa K Micklesfield","doi":"10.1017/S0007114525000029","DOIUrl":"10.1017/S0007114525000029","url":null,"abstract":"Although research on the relationship between lean body mass and blood pressure (BP) has been inconsistent, most studies reported that measures of lean body mass are associated with a higher risk of hypertension. We explored relationships between body composition (fat and skeletal muscle mass) and BP in 1162 young adult African women. Dual-energy X-ray absorptiometry-derived measures of whole-body, central and arm fat mass were associated with higher systolic and diastolic BP, while leg fat percentage was associated with lower systolic and diastolic BP. However, only the associations with diastolic BP remained after adjusting for appendicular skeletal muscle mass (ASM). ASM was associated with higher systolic and diastolic BP, before and after adjusting for whole-body fat percentage and visceral adipose tissue. While there was no overlap in targeted proteomics of BP and body composition, REN was lower in the elevated BP than the normal BP group and was inversely associated with diastolic BP (false rate discovery adjusted P< 0·050). Several proteins were positively associated with both visceral adipose tissue and ASM (LEP, FABP4, IL6 and GGH) and negatively associated with both visceral adipose tissue and ASM (ACAN, CELA3A, PLA2G1B and NCAM1). NOTCH3, ART3, COL1A1, DKK3, ENG, NPTXR, AMY2B and CNTN1 were associated with lower visceral adipose tissue only, and IGFBP1 was associated with lower ASM only. While the associations between body fat and BP were not independent of skeletal muscle mass, the associations between muscle mass and BP were independent of overall and central adiposity in young adult African women. Future interventions targeting muscle mass should also monitor BP in this population.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-15"},"PeriodicalIF":3.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender differences in the association between adherence to healthy diet principles and adherence to cardiopreventive medication among adults from Québec (Canada). 来自魁北克（加拿大）的成年人坚持健康饮食原则和坚持心脏预防药物之间关系的性别差异。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-16 DOI: 10.1017/S0007114525000030

Lise Leblay, Jacob Lessard-Lord, Jean-Sébastien Paquette, Line Guénette, Jean-Philippe Drouin-Chartier

{"title":"Gender differences in the association between adherence to healthy diet principles and adherence to cardiopreventive medication among adults from Québec (Canada).","authors":"Lise Leblay, Jacob Lessard-Lord, Jean-Sébastien Paquette, Line Guénette, Jean-Philippe Drouin-Chartier","doi":"10.1017/S0007114525000030","DOIUrl":"10.1017/S0007114525000030","url":null,"abstract":"Adherence to healthy diet principles and to cardiopreventive medication, both key behaviours in CVD prevention, is known to differ between women and men. Whether these adherence behaviours are differentially related among women and men has never been thoroughly assessed. The objective was to assess gender differences in the association between adherence to healthy diet principles and to cardiopreventive medication in adults free of CVD. This cross-sectional study included 268 women and 204 men from the CARTaGENE cohort (Québec, Canada) who were using antihypertensive and/or cholesterol-lowering medication. Adherence to healthy diet principles was assessed using the Alternate Healthy Eating Index (AHEI, %), calculated from a validated FFQ assessing diet in the 12-month preceding its completion. Medication adherence was assessed using the daily pharmacotherapy possession rate (DPPR, %), calculated from prescription claim data over the same 12-month period. In multivariable-adjusted analyses, an inverse association between AHEI and DPPR was observed among men (βAHEI for 10 % increment in DPPR = -0·65 %; 95 % CI -1·28 %, -0·03 %; P = 0·04), while it tended to be positive among women (β = 0·44 %; 95 % CI -0·11 %, 1·00 %; P = 0·12; Pgender×DPPR = 0·01). The negative association between AHEI and DPPR was stronger among men who never smoked or used cholesterol-lowering medication only. Among women, the positive association was stronger and statistically significant among those with obesity or using ≥ 3 medications simultaneously. Association between adherence to healthy diet principles and to cardiopreventive medication differs between women and men, with men potentially facing greater challenges in achieving optimal complementarity between these two behaviours.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-11"},"PeriodicalIF":3.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of folate deficiency and different doses of folic acid supplementation on liver diseases. 叶酸缺乏和不同剂量叶酸补充剂对肝病的影响。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-14 Epub Date: 2024-11-13 DOI: 10.1017/S000711452400285X

Huan Ma, Hui Liu, Yu-Ting Yang, Mei Han, Chun-Meng Jiang

引用次数: 0

Exercise combined with vitamin D supplementation has additive health effects on short physical performance battery and stair climbing in older adults: a scope review of randomised controlled trials. 运动结合维生素 D 补充剂对老年人的 SPPB 和爬楼梯有额外的保健作用：随机对照试验的范围回顾。

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-14 Epub Date: 2024-11-20 DOI: 10.1017/S0007114524002320

Jinghua Zhang, Zheng Zhu, YanJun Niu, Zhen-Bo Cao

{"title":"Exercise combined with vitamin D supplementation has additive health effects on short physical performance battery and stair climbing in older adults: a scope review of randomised controlled trials.","authors":"Jinghua Zhang, Zheng Zhu, YanJun Niu, Zhen-Bo Cao","doi":"10.1017/S0007114524002320","DOIUrl":"10.1017/S0007114524002320","url":null,"abstract":"This scoping review aimed to evaluate the effect of exercise combined with vitamin D supplementation on skeletal muscle health in older individuals. We implemented a systematic search of electronic databases, including PubMed, the Cochrane Library, Web of Science and Embase, which was conducted from the time of library construction to January 2024. Eligible studies were randomised controlled trials including men and women aged ≥ 65 years or mean age ≥ 65 years; exercise training and vitamin D supplementation; outcomes of muscular strength, function, muscular power, body composition and quality of life; and results compared with those of exercise intervention alone. The results showed thirteen studies including 1483 participants were identified. The proportions of male and female sex were 22·05 and 77·95 %, respectively. Exercise intervention methods included resistance exercises and multimodal exercise training. All vitamin D interventions involved supplementation with vitamin D3. A significant increase was identified in short physical performance battery and stair climbing but not in skeletal muscle mass, skeletal strength, the timed up and go test and gait speed in older adults after exercise combined with vitamin D supplementation. In conclusion, exercise combined with vitamin D supplementation has additive health effects on short physical performance battery and stair climbing. Furthermore, when vitamin D was deficient at baseline, the combined effect of exercise and vitamin D intervention significantly increased the timed up and go test and gait speed in older adults. In future randomised controlled trials on this topic, baseline vitamin D nutritional status, health condition and sex should be considered.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"48-57"},"PeriodicalIF":3.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Butyrate attenuates high-fat diet-induced glomerulopathy through GPR43-Sirt3 pathway. 丁酸盐通过GPR43-Sirt3途径减轻高脂饮食诱发的肾小球病变

IF 3 3区医学

British Journal of Nutrition Pub Date : 2025-01-14 Epub Date: 2024-11-22 DOI: 10.1017/S0007114524002964

Ying Shi, Lin Xing, Ruoyi Zheng, Xin Luo, Fangzhi Yue, Xingwei Xiang, Anqi Qiu, Junyan Xie, Ryan Russell, Dongmei Zhang

{"title":"Butyrate attenuates high-fat diet-induced glomerulopathy through GPR43-Sirt3 pathway.","authors":"Ying Shi, Lin Xing, Ruoyi Zheng, Xin Luo, Fangzhi Yue, Xingwei Xiang, Anqi Qiu, Junyan Xie, Ryan Russell, Dongmei Zhang","doi":"10.1017/S0007114524002964","DOIUrl":"10.1017/S0007114524002964","url":null,"abstract":"The incidence of obesity-related glomerulopathy (ORG) is rising worldwide with very limited treatment methods. Paralleled with the gut–kidney axis theory, the beneficial effects of butyrate, one of the short-chain fatty acids (SCFA) produced by gut microbiota, on metabolism and certain kidney diseases have gained growing attention. However, the effects of butyrate on ORG and its underlying mechanism are largely unexplored. In this study, a mice model of ORG was established with a high-fat diet feeding for 16 weeks, and sodium butyrate treatment was initiated at the 8th week. Podocyte injury, oxidative stress and mitochondria function were evaluated in mice kidney and validated in vitro in palmitic acid-treated-mouse podocyte cell lines. Further, the molecular mechanisms of butyrate on podocytes were explored. Compared with controls, sodium butyrate treatment alleviated kidney injuries and renal oxidative stress in high-fat diet-fed mice. In mouse podocyte cell lines, butyrate ameliorated palmitic acid-induced podocyte damage and helped maintain the structure and function of the mitochondria. Moreover, the effects of butyrate on podocytes were mediated via the GPR43-Sirt3 signal pathway, as evidenced by the diminished effects of butyrate with the intervention of GPR43 or Sirt3 inhibitors. In summary, we conclude that butyrate has therapeutic potential for the treatment of ORG. It attenuates high-fat diet-induced ORG and podocyte injuries through the activation of the GPR43-Sirt3 signalling pathway.","PeriodicalId":9257,"journal":{"name":"British Journal of Nutrition","volume":" ","pages":"1-10"},"PeriodicalIF":3.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0