Brazilian oral researchPub Date : 2025-03-31eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.008
Joana Leticia Schorr, Felippe José Almeida Loureiro, Lauren Frenzel Schuch, Vivian Petersen Wagner, Vinicius Coelho Carrard, Matheus Neves, Marco Antonio Trevizani Martins, Manoela Domingues Martins
{"title":"Oral adverse effects of head and neck radiotherapy with/without chemotherapy in a southern Brazil hospital.","authors":"Joana Leticia Schorr, Felippe José Almeida Loureiro, Lauren Frenzel Schuch, Vivian Petersen Wagner, Vinicius Coelho Carrard, Matheus Neves, Marco Antonio Trevizani Martins, Manoela Domingues Martins","doi":"10.1590/1807-3107bor-2025.vol39.008","DOIUrl":"10.1590/1807-3107bor-2025.vol39.008","url":null,"abstract":"<p><p>The aim of this study was to evaluate the main oral adverse effects and their relationship with dental care before radiotherapy (RT) and combined RT and chemotherapy (RT+CT). Additionally, we assessed the association of other risk factors with the development of these adverse effects. This paper is a retrospective cross-sectional analytical study of data from medical records of patients with head and neck cancer (HNC) who underwent RT or RT+CT attended at the stomatology unit in a southern Brazil hospital. The records of 78 patients with HNC were accessed. Demographic data, tumor characteristics, cancer treatment, follow-up data, adverse effects, and dental treatment prior to RT were evaluated individually for descriptive analysis. Kaplan-Meier survival curves were plotted. Risk factors were assessed using chi-square or Mann-Whitney test. The results showed that most patients were male (88.3%) in their 6th decade of life. Tumors were mostly located in the oral cavity (52.6%) and squamous cell carcinoma was the main diagnosis (94.8%). Most cases were diagnosed in advanced stages (67.9%). RT was of 2D or 3D types in 93.6% of patients. Oral adverse effects were observed in 94.7% of patients treated with RT or RT+CT. Osteoradionecrosis (ORN), oral mucositis (OM), candidiasis, and xerostomia were the main complications. Patients who received 2D RT had higher risk of developing ORN and xerostomia compared to those who received 3D RT. The risk of developing ORN was higher in smokers compared to non-smokers and in patients who had not previously consulted a dentist. This study showed that patients who underwent RT for HNC have a high occurrence of oral complications. Dentists play a key role in the management of these oral side effects.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e008"},"PeriodicalIF":1.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-03-10eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.029
Patrícia Correia de Siqueira, Lorrayne da Costa Cassimiro Soares, Keryda Ramos Di Machado Wanderley, Lara Borges de Deus, Higor Venâncio de Melo, Maria Paula Andrade Ávila, Lucas Rodrigues de Araújo Estrela, Cyntia Rodrigues de Araújo Estrela
{"title":"The impact of intracanal medicaments on crown color, pH, and antimicrobial activity: a comparative study.","authors":"Patrícia Correia de Siqueira, Lorrayne da Costa Cassimiro Soares, Keryda Ramos Di Machado Wanderley, Lara Borges de Deus, Higor Venâncio de Melo, Maria Paula Andrade Ávila, Lucas Rodrigues de Araújo Estrela, Cyntia Rodrigues de Araújo Estrela","doi":"10.1590/1807-3107bor-2025.vol39.029","DOIUrl":"10.1590/1807-3107bor-2025.vol39.029","url":null,"abstract":"<p><p>This study aimed to compare the effects of intracanal medication pastes Bio-C Temp® (BC), UltraCal XS® (UC), and Pure Calcium Hydroxide (CH) on crown color change, pH, and antimicrobial activity. Color change was assessed using the CIEL*a*b* color space system parameter. pH values were measured at 3, 24, 72, and 168 hours. Antimicrobial activity was evaluated using agar diffusion and direct exposure tests. Statistical analyses were conducted using ANOVA, Kruskal-Wallis, and Friedman tests (α = 0.05). After 15 days, BC exhibited significantly greater color variation than the control, and higher L* values at 60 days compared to baseline (p < 0.05). BC demonstrated lower pH values than UC and CH at 3 and 72 hours (p < 0.05). In the agar diffusion test, BC produced a smaller microbial inhibition halo than UC and CH. In the direct exposure test, CH completely inhibited microbial growth, whereas BC showed microbial growth at all evaluated time points. In conclusion, BC resulted in greater crown color change, lower pH, and reduced antimicrobial activity compared to UC and CH.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e029"},"PeriodicalIF":1.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Educational strategies on tooth avulsion for teachers: an intervention study.","authors":"Thaíssa Chagas Fochi, Simone Tuchtenhagen, Juliane Carla Taufer, Fernanda Ruffo Ortiz","doi":"10.1590/1807-3107bor-2025.vol39.031","DOIUrl":"10.1590/1807-3107bor-2025.vol39.031","url":null,"abstract":"<p><p>Tooth avulsion is an emergency dentoalveolar trauma, and knowledge of this condition can improve the prognosis of trauma. This study aimed to assess and improve elementary school teachers' knowledge of tooth avulsion using two educational intervention methods. Data were obtained through a parallel, blinded educational intervention study involving 116 teachers from public and private schools. They participated and completed a structured questionnaire regarding the immediate measures required for dentoalveolar trauma to permanent teeth, storage methods, and the ideal time for the dental element to remain outside the socket. After randomly assigning teachers to the leaflet and video groups, they were provided guidance on dentoalveolar trauma and completed the questionnaire again. Comparison tests, namely chi-square and logistic regression, were performed to assess the post-intervention responses and compare the differences between the groups. The results were interpreted with a significance level of 5% and a 95% confidence interval. Most responses showed a statistically significant difference (p < 0.05), indicating that the interventions improved teachers' knowledge, except for questions on time and immediate management after dentoalveolar trauma (p > 0.05). There was no statistical difference between the intervention methods, demonstrating that both the leaflets and videos improved teachers' knowledge (p > 0.05). The results revealed that teachers' knowledge of tooth avulsion improved regardless of the format of the educational intervention.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e031"},"PeriodicalIF":1.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-03-10eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.030
Daniel Henrique Koga, Marcos Martins Curi, Joel Ferreira Santiago Junior, Aldieris Alves Pesqueira, Wagner José Sousa Carvalho, Márcio Campaner, Camila Lopes Cardoso
{"title":"Pterygoid implant: extensometric and photoelastic analysis of a maxillary rehabilitation model.","authors":"Daniel Henrique Koga, Marcos Martins Curi, Joel Ferreira Santiago Junior, Aldieris Alves Pesqueira, Wagner José Sousa Carvalho, Márcio Campaner, Camila Lopes Cardoso","doi":"10.1590/1807-3107bor-2025.vol39.030","DOIUrl":"10.1590/1807-3107bor-2025.vol39.030","url":null,"abstract":"<p><p>Pterygoid implants have been demonstrated to have a high success rate. Nevertheless, there are few biomechanical tests to evaluate the tensile forces induced by force dissipation in peri-implant tissues. This study employed photoelasticity and extensometry to demonstrate and compare the biomechanical behavior of non-axial implants in a pterygoid model and a conventional model of oral rehabilitation, thus allowing for qualitative and quantitative analysis. Two models received an implant measuring 3.75 x 13 mm in the canine pillar at a 90 ° angle to the Frankfurt plane. In the control group, an implant with a diameter of 3.75 mm and a length of 11 mm was placed in the maxillary tuberosity parallel the medial implant. In the study group, an implant with a diameter of 3.75 mm and a length of 11 mm was installed with an angulation of 45 degrees in the antero-posterior direction and 15 degrees in the buccal-palatal direction, with apical anchorage in the pterygoid process of the sphenoid bone. In the extensometric analysis, the models were subjected to five cycles of repeated axial tensile loading (100 N) at a rate of 0.5 mm/min. A computer was connected to the amplifier in order to record the output signal of the polyurethane surface, and the acquisition system software was employed to record the data. The data were analyzed in accordance with data distribution, as determined by the Shapiro-Wilk test and equality of variance. Subsequently, the data were classified according to the variables. The Student's t-test was employed when normal distribution of variances was identified, whereas the Mann-Whitney U test was utilized for data with non-normal distribution. A 5% significance level was employed. In the photoelastic analysis, replicas of both configurations were produced using photoelastic resin. The models were subjected to a single axial loading cycle, with a load of 100 N applied at a rate of 0.5 mm/min, and the resulting stress was observed under a circular polariscope. Photographs were taken at two time points: before and after loading. These images were then processed by the same operator using a computer graphics program, allowing for a more straightforward analysis of stress distribution. This was achieved by the formation of isochromatic fringes. The results of the strain gauge analysis revealed no statistically significant differences between the two groups (p = 0.37) or between the anterior (p = 0.08) and posterior (p = 0.74) implants. The photoelasticity analysis revealed the presence of high-intensity isochromatic fringes at the apex of the axial implant in the control model, as well as in the cervical-distal and apical regions of the pterygoid implant, where a high concentration was also observed. Although no statistically significant results were obtained from the quantitative analysis, our findings suggest that the favorable outcomes observed in the clinical studies are due to the high force dissipation observed in the pterygoid","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e030"},"PeriodicalIF":1.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-02-24eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.026
Julio Cesar Ramos Cadilho, Paôla Caroline da Silva Mira, Jéssica Peixoto Bem, Penélope Swerts Rodrigues, Francisco José de Queiroz Thomé, Harley Francisco de Oliveira, Fernando Marin Torres, Francisco Wanderley Garcia Paula-Silva, Paulo Nelson-Filho, Alexandra Mussolino de Queiroz
{"title":"Effects of radiation therapy on the morphology and composition of root dentin and cementum in primary teeth.","authors":"Julio Cesar Ramos Cadilho, Paôla Caroline da Silva Mira, Jéssica Peixoto Bem, Penélope Swerts Rodrigues, Francisco José de Queiroz Thomé, Harley Francisco de Oliveira, Fernando Marin Torres, Francisco Wanderley Garcia Paula-Silva, Paulo Nelson-Filho, Alexandra Mussolino de Queiroz","doi":"10.1590/1807-3107bor-2025.vol39.026","DOIUrl":"10.1590/1807-3107bor-2025.vol39.026","url":null,"abstract":"<p><p>The aim of this study was to evaluate, in vitro, the effects of radiation therapy on the morphology and chemical composition of root dentin and cementum of primary teeth. Roots of human primary teeth were exposed to varying doses of irradiation using a linear accelerator: Group 1 = irradiation dose of up to 30 Gy (n= 6); Group 2 = irradiation dose of up to 42 Gy (n= 6); and Group 3 = irradiation dose of up to 54 Gy (n= 6). Non-irradiated human deciduous teeth were used as controls (n= 3). Energy-dispersive X-ray spectroscopy (EDX) data were analyzed using the chi-square test (alpha = 5%). The morphological evaluation was performed using scanning electron microscopy (SEM). In the cementum, radiation increased inorganic composition and decreased oxygen levels. However, no morphological changes were observed. In the root dentin, obliterated dentinal tubules were observed in specimens irradiated with 54 Gy, with no changes in composition. Thus, radiation therapy significantly altered the morphology and composition of important tooth structures such as dentin and cementum, in primary teeth.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e026"},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caries risk factors among Indonesian adults: insights from the national health survey.","authors":"Yuanita Lely Rachmawati, Agustine Hanafi Putri, Rahmavidyanti Priyanto, Khansa Catraliya Nabilah, Ananda Dhea Salsabila Gani, Tuti Ningseh Mohd-Dom","doi":"10.1590/1807-3107bor-2025.vol39.025","DOIUrl":"10.1590/1807-3107bor-2025.vol39.025","url":null,"abstract":"<p><p>Although caries is a preventable disease, it is still a health burden in all countries in all age categories. This study aimed to identify the determinants associated with caries risk factors in Indonesian adults. This secondary analysis used 2018 National Health Survey data, which included 37,057 respondents aged ≥ 15 years. The sampling design was based on census blocks selected using linear systematic sampling with probability proportional to size (PPS). The survey included an interview to collect data on sociodemographic characteristics, oral health practice, and health behavior. An oral examination was conducted to measure the DMFT (decayed, missing, filled- teeth) index. Multivariable models were generated to estimate the odds ratio (OR) and confidence intervals (95% CI) using caries as the dependent variable. The highest average DMFT index was seen in those respondents aged over 45 years, those from rural areas, individuals with low formal education, those who consumed sweets and sugary beverages at least once a day, those who did not brush their teeth regularly, and those who smoked. The multivariable analysis showed the potential risk of caries: risk of 19.51 times for older adults, 74% for male, 94% for those living in rural areas, 1.62 times for those with lower formal education, 78% for those with no dental visits, 1.18 times for those who eat sweets often, 1.37 times for those who drink sugary beverages often, 1.48 times for those who do not brush their teeth regularly, and 1.3 times for those who smoke. The multifaceted nature of caries in the Indonesian adult population highlights the influence of various factors, ranging from lifestyle habits and oral hygiene practices to access to dental services, age, and educational level.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e025"},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-02-21eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.024
Mariane Cintra Mailart, Ilirida Berisha, Ana Sofia Arana Reinales, Samira Helena Niemeyer, Alessandra Bühler Borges, Tommy Baumann, Thiago Saads Carvalho
{"title":"Effect of pellicle modification with polyphenol-rich solutions on enamel erosion and abrasion.","authors":"Mariane Cintra Mailart, Ilirida Berisha, Ana Sofia Arana Reinales, Samira Helena Niemeyer, Alessandra Bühler Borges, Tommy Baumann, Thiago Saads Carvalho","doi":"10.1590/1807-3107bor-2025.vol39.024","DOIUrl":"10.1590/1807-3107bor-2025.vol39.024","url":null,"abstract":"<p><p>The aim of the study was to compare the effect of salivary pellicle modification with polyphenol-rich solutions containing fluoride on enamel erosion and abrasion. Human enamel specimens (n = 14/group) were assigned to five pellicle-modifying groups: GSE+F (grape seed extract +500 ppm F-); CRA+F (cranberry extract +500 ppm F-); NaF (sodium fluoride solution -5 00ppm F-); Sn+F (commercial solution, SnCl2/NaF/AmF); and DW (deionized water, negative control). The specimens were submitted to 5 cycles, each one consisting of pellicle formation (120μl, 30 min, 37°C, no agitation), followed by pellicle modification with the experimental solutions (5 ml, 2 min, 25ºC, 70 rpm), and subsequent salivary pellicle formation (120 μl, 60 min, 37°C, no agitation). The specimens were then submitted to erosion (1% citric acid, 10 ml, 1 min, pH 3.6, 70 rpm, 25ºC). Subsequently, they were submitted to abrasion with a fluoride-based toothpaste slurry in a toothbrushing machine (50 strokes, 200 g load, 2 min exposed to slurry). The enamel surface was evaluated with an optical profilometer at baseline and after the 5 cycles to assess the surface loss. Data were submitted to Kruskal-Wallis followed by a multiple comparisons test (α = 0.05). Significant differences were found between the tested solutions (p <0.001). The highest surface loss was verified in the DW group (p < 0.001). The other tested solutions (GSE+F, CRA+F, Sn+F, NaF) promoted significant enamel protection against the erosive-abrasive challenges with no differences between them. In conclusion, the modification of salivary pellicle with both polyphenol-rich, commercial solution and fluoride solutions were able to protect the enamel surface from erosion and abrasion.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e024"},"PeriodicalIF":1.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-02-21eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.021
Larissa Chaves Morais de Lima, Érick Tássio Barbosa Neves, Matheus França Perazzo, Veruska Medeiros Martins Bernardino, Samara Ellen da Silva, Saul Martins de Paiva, Fernanda de Morais Ferreira, Ana Flávia Granville-Garcia
{"title":"Structural equation modeling of the association between oral health literacy and dental caries in children.","authors":"Larissa Chaves Morais de Lima, Érick Tássio Barbosa Neves, Matheus França Perazzo, Veruska Medeiros Martins Bernardino, Samara Ellen da Silva, Saul Martins de Paiva, Fernanda de Morais Ferreira, Ana Flávia Granville-Garcia","doi":"10.1590/1807-3107bor-2025.vol39.021","DOIUrl":"10.1590/1807-3107bor-2025.vol39.021","url":null,"abstract":"<p><p>The aim of this study was to explore the association between oral health literacy (OHL) and dental caries in children, evaluating the direct and indirect effects of brushing frequency, obesity, and socioeconomic factors. A cross-sectional study was conducted with 739 schoolchildren aged eight to ten years and their parents/caregivers who answered a questionnaire addressing sociodemographic characteristics and oral hygiene habits as well as the OHL - Adult Questionnaire. Cavitated dental caries in the schoolchildren was evaluated using International Caries Detection and Assessment System criteria. Descriptive analysis was performed, followed by structural equation modeling into the theoretical model (95% CI). Goodness-of-fit indices were considered satisfactory (root mean square error of approximation < 0.06; comparative fit index > 0.90-0.95; standardized root mean square residual < 0.10 and Tucker-Lewis Index > 0.90-0.95). Mother's age (standardized coefficient [SC]: -0.08; p < 0.01), caregiver's schooling (SC: -0.22; p < 0.01), obesity (SC: 0.13; p < 0.01), and brushing frequency (SC: -0.09; p < 0.01) had a direct effect on dental caries, whereas OHL had an indirect influence on the outcome. Mother's age, caregiver's schooling, brushing frequency, and obesity directly affected the occurrence of cavitated carious lesions in children in the mixed dentition phase, whereas OHL had an indirect effect on this clinical outcome.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e021"},"PeriodicalIF":1.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-02-21eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.023
Alessandra Figueiredo de Souza, Sâmila Gonçalves Barra, Amanda Leal Rocha, Larissa Marques Bemquerer, Sicilia Rezende Oliveira, Larissa Nayane Carvalho, Tânia Mara Pimenta Amaral, Claudia Borges Brasileiro, Fernando Oliveira Costa, Leandro Napier Souza, Bruno Muzzi Camargos, Enaldo Melo de Lima, Adaliene Versiani Matos Ferreira, Joyce Elisa Heredia, Marina Chaves de Oliveira, Soraia Macari, Lucas Guimarães Abreu, Ricardo Alves Mesquita, Tarcília Aparecida Silva
{"title":"Bone mineral density in patients using aromatase inhibitors: a clinical, nutritional, and quality of life assessment.","authors":"Alessandra Figueiredo de Souza, Sâmila Gonçalves Barra, Amanda Leal Rocha, Larissa Marques Bemquerer, Sicilia Rezende Oliveira, Larissa Nayane Carvalho, Tânia Mara Pimenta Amaral, Claudia Borges Brasileiro, Fernando Oliveira Costa, Leandro Napier Souza, Bruno Muzzi Camargos, Enaldo Melo de Lima, Adaliene Versiani Matos Ferreira, Joyce Elisa Heredia, Marina Chaves de Oliveira, Soraia Macari, Lucas Guimarães Abreu, Ricardo Alves Mesquita, Tarcília Aparecida Silva","doi":"10.1590/1807-3107bor-2025.vol39.023","DOIUrl":"10.1590/1807-3107bor-2025.vol39.023","url":null,"abstract":"<p><p>The use of aromatase inhibitors (AIs) leads to an imbalance in bone remodeling and can cause osteoporosis. This study aimed to identify clinical, periodontal, nutritional, and biochemical determinants of bone mineral density (BMD) changes in patients using AIs. The sample consisted of 40 women using AIs and 32 controls. BMD was assessed by dual X-ray absorptiometry (DXA). Data on nutritional, anthropometric, oral and periodontal status, and oral health-related quality of life (OHRQoL) were collected. Cytokines and adipokines were quantified in saliva and serum. Thirty-nine of the 72 women had low BMD, with a similar distribution in the control and AIs groups. BMD was lower in older women using AIs (p = 0.009) and in smokers (p = 0.034). Anthropometric assessment demonstrated that women with low BMD who used AIs had lower weight (p = 0.028). Although the frequency of periodontitis was similar in all groups, higher IL-6 (p = 0.004), IL-1β (p = 0.002), and IL-33 (p = 0.006) levels were associated with poor periodontal status. Women who used AIs were 1.18 times more likely to report better OHRQoL than controls. While advanced age, smoking, and lower weight are factors associated with low BMD, the use of antiresorptive agents was a protective factor for maintaining BMD in women using AIs.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e023"},"PeriodicalIF":1.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brazilian oral researchPub Date : 2025-02-21eCollection Date: 2025-01-01DOI: 10.1590/1807-3107bor-2025.vol39.019
Leandro Edgar Pacheco, Fernanda Balestrero Cassiano, Vitor de Toledo Stuani, Isabela Sanches Pompeo da Silva, Larissa Alamo, Matheus de Castro Costa, Marcella Fernandes Lovison, Sergio Kyioshi Ishikiriama, Rafael Francisco Lia Mondelli, Diana Gabriela Soares
{"title":"Properties of 3D-Printed resins for interim restorations: effects of printing and post-curing protocols.","authors":"Leandro Edgar Pacheco, Fernanda Balestrero Cassiano, Vitor de Toledo Stuani, Isabela Sanches Pompeo da Silva, Larissa Alamo, Matheus de Castro Costa, Marcella Fernandes Lovison, Sergio Kyioshi Ishikiriama, Rafael Francisco Lia Mondelli, Diana Gabriela Soares","doi":"10.1590/1807-3107bor-2025.vol39.019","DOIUrl":"10.1590/1807-3107bor-2025.vol39.019","url":null,"abstract":"<p><p>This study analyzed the properties of three-dimensional (3D)-printed resins designed for interim restorations and subjected to different printing and post-curing protocols. Specimens were manufactured with two 3D-printed resins for interim restorations at varying exposure times per layer, in accordance with the manufacturer's recommendations (Tm) or using a calibrator (Tc). Subsequently, the specimens were post-cured for 5, 10, or 15 min. Trueness, surface roughness, and color analyses were performed. For biological characterization, the specimens were incubated for up to 72 h in a culture medium, and the extracts were applied at 24-h intervals to keratinocyte cells (NOK-Si). Cellular metabolism was evaluated after 1 and 3 days. Leaching of residual monomers from the extracts was evaluated. Data were analyzed using two-way analysis of variance (ANOVA) and Tukey's honestly significant difference (HSD) test (α = 5%). The exposure time beyond Tc resulted in specimens with increased trueness and smoother surfaces. Color stability was also influenced by the type of resin and post-curing time; the longer the time, the greater the color change, allowing for brighter and clearer specimens. The resins were cytocompatible with NOK-Si, regardless of the printing and post-curing parameters, although residual monomer leaching was affected by the parameters tested. The evaluated resins were cytocompatible; however, variations in the exposure times per layer and post-curing duration affected their roughness, leaching, trueness, and color stability.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e019"},"PeriodicalIF":1.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}