Brazilian oral research最新文献

{"title":"Evaluation of locator versus TITACH attachments for mandibular 2-implant overdentures: a one-year randomized controlled clinical trial.","authors":"Heba Wageh Abozaed, Mohammed Ahmed Eladrosi, Moustafa Abdou Elsyad","doi":"10.1590/1807-3107bor-2026.vol40.005","DOIUrl":"10.1590/1807-3107bor-2026.vol40.005","url":null,"abstract":"<p><p>Implant overdenture attachments serve as the crucial link between dental implants and removable dentures, significantly enhancing the stability, retention, and function of the prosthesis. This study was designed to assess the effectiveness of locator and TITACH attachments in retaining mandibular two-implant overdentures, maximum bite force, and marginal bone loss. The study involved 36 edentulous patients, each receiving new complete dentures (CDs) designed with the bilateral balanced occlusal concept. Two implants were positioned in the mandibular canine regions. Participants were randomly assigned to two equal groups: Group I (LOA) with overdentures using locator attachments, and Group II (TIA) with overdentures using TITACH attachments. Retention and maximum bite forces were measured using a digital force meter and bite force transducers at baseline (T0), and at 6 months (T6), and 12 months (T12) post-insertion. After insertion, marginal bone loss (MBL) was evaluated using digital periapical radiographs at T6 and T12. Retention significantly decreased over time across all groups (p = 0.024 for CD, p < 0.001 for LOA and TIA). Maximum bite forces significantly declined for LOA (p = 0.007) and TIA (p = 0.003) at all measurement intervals. TIA demonstrated the highest retention and bite forces, followed by LOA, while CDs exhibited the lowest retention and bite forces. TIA was associated with significantly greater MBL than LOA (p = 0.002 and p < 0.001 for TIA). TITACH attachments showed superior retention and maximum bite force compared to locator attachments. Both attachment types offered improved retention and maximum bite forces relative to complete dentures. Additionally, locator attachments were associated with less peri-implant bone loss than TITACH attachments.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e005"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of titanium dioxide nanotubes in Ca(OH)2-based intracanal medicaments on odontoblast-like cells.","authors":"Matheus Araújo Brito Santos Lopes, Bruna Carolina Costa, Francisco Humberto Nociti Junior, Paulo Noronha Lisboa Filho, Kamila Rosamilia Kantovitz","doi":"10.1590/1807-3107bor-2026.vol40.002","DOIUrl":"10.1590/1807-3107bor-2026.vol40.002","url":null,"abstract":"<p><p>This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic activity of mouse dental papilla cells (MDPC-23). Five experimental groups were evaluated (n=3 per group): Cells (control), Calen, Calen + 3wt% nTiO2, Ultracal, and Ultracal + 3wt% nTiO2. Cell proliferation, viability, and mitochondrial metabolic activity were assessed using the Trypan Blue exclusion and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays at 24, 48, and 72 h. Data analysis included the Shapiro-Wilk and Levene tests and generalized linear models (p<0.05). At 24 and 48 h, both Ultracal and Ultracal + 3wt% nTiO2 showed significantly higher proliferation than the Calen groups (p<0.0001). The control group (Cells) exhibited the highest viable cell counts (p<0.0005). At 72 h, Calen + 3wt% nTiO2 showed the lowest proliferation compared with both the Cells and the Ultracal groups (p<0.0001). No significant differences were observed in non-viable cell counts or viable/non-viable ratios over time (p>0.05). Furthermore, Calen and Calen + 3 wt% nTiO2 at 24 and 48 h, as well as Calen + 3wt% nTiO2 at 72 h, demonstrated the lowest metabolic activity (p<0.0001), with no significant effect of nTiO2 (p>0.05). No significant intra-group differences over time were observed for the Cells or Ultracal groups (p=0.0608 and p=0.1417, respectively). Overall, the incorporation of nTiO2 did not adversely affect the biological parameters of Ca(OH)2-based ICMs assessed in this study. Further investigations are warranted to elucidate potential clinical implications.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e002"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malocclusions in primary teeth and quality of life: perception of preschoolers and their parents/guardians.","authors":"Laerte José da Silva Coqueiro, Giovanna Vytoria Marinho Silvestre, Cristiane Baccin Bendo, Neusa Barros Dantas Neta, Francisca Aline da Silva Matias, Cacilda Castelo Branco Lima, Marcoeli Silva Moura, Lúcia de Fátima Almeida de Deus Moura, Marina de Deus Moura de Lima","doi":"10.1590/1807-3107bor-2026.vol40.004","DOIUrl":"10.1590/1807-3107bor-2026.vol40.004","url":null,"abstract":"<p><p>Malocclusions in primary teeth affect chewing, speech, and aesthetics. Few studies have assessed their impact on preschoolers' self-reported quality of life. This study aims to determine the association between malocclusions in primary teeth and preschoolers' quality of life based on reports from children and their parents/guardians. A cross-sectional study was conducted Using a stratified, simple, randomly probabilistic sample. Based on sample size estimation, the study included 566 five-year-old preschoolers and their parents/guardians from Teresina, Brazil. Pediatric Quality of Life InventoryTM questionnaire and sociodemographic forms were applied, and clinical examination was performed. The dmft index, modified developmental defects of enamel, and Foster & Hamilton criteria were used for diagnosis. Descriptive analysis and Poisson regression were performed (p < 0.05; 95% CI). Prevalence of malocclusion was 51.2%. Parents/guardians reported edge-to-edge overjet negatively affected physical capacity (RR = 1.11; 95%CI: 1.02-1.20) and social aspects (RR = 1.11; 95%CI: 1.03-1.19). According to children's self-reports, posterior crossbite affected the total score (RR = 1.43; 95%CI: 1.03-1.97) and oral health (RR = 1.08; 95%CI: 1 .04-1.13), whereas reduced overbite was linked to negative effects on the emotional aspect (RR = 1.10; 95%CI: 1.01-1.18) and oral health (RR = 1.08; 95%CI: 1.01-1.16). Malocclusions have a negative impact on the quality of life of preschoolers, as reported by parents and children.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e004"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental tissue fractures and their relationship with deciduous molar hypomineralization, molar incisor hypomineralization, and psychosomatic factors: a cross-sectional study.","authors":"Jaine Viviane Silva, Lucas de Lima Oliveira Barbosa, Isabel Cristina Celerino de Moraes Porto, Valdeci Elias Dos Santos Junior","doi":"10.1590/1807-3107bor-2026.vol40.001","DOIUrl":"10.1590/1807-3107bor-2026.vol40.001","url":null,"abstract":"<p><p>This study aimed to investigate the relationship between post-eruptive dental fractures, hypomineralization, and psychosomatic factors such as anxiety, headache, awake bruxism, and temporomandibular disorder (TMD) in children aged 7 to 12 years. A cross-sectional study involving 274 children was conducted using clinical examinations based on the European Academy of Pediatric Dentistry (EAPD) criteria for the diagnosis of hypomineralization and post-eruptive breakdown. Structured and validated questionnaires were administered through interviews to assess psychosomatic factors such as anxiety, headache, awake bruxism, and TMD. Statistical analysis included descriptive and inferential analyses using Fisher's exact test and the chi-square test. The margin of error was 5%, with a 95% confidence interval. Tissue breakdown was observed in 6.2% of children, with a higher prevalence in posterior teeth. A significant association was found between tissue breakdown and hypomineralization in deciduous (p=0.002) and permanent teeth (p < 0.001), especially when hypomineralization presented as yellow-brown (p < 0.001). Anxiety, awake bruxism, and TMD were not significantly associated with such fractures, but they were significantly associated with headache (p = 0.023). Additionally, dental caries (p = 0.003) and occlusal wear (p < 0.001) were associated with tissue breakdown. Post-eruptive breakages were found to be associated with dental enamel hypomineralization in deciduous and permanent teeth. Furthermore, dental caries and occlusal wear were identified as key contributing factors for these fractures. In conclusion, post-eruptive fractures were associated with enamel hypomineralization in both deciduous and permanent teeth, as well as with dental caries and occlusal wear. Among psychosomatic factors, only headache showed a significant association.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e001"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of dental caries lesions in Costa Rican children under 81 months living in poverty.","authors":"Sylvia Gudiño-Fernandez, Katherine Molina-Chaves, Adrian Gomez-Fernandez","doi":"10.1590/1807-3107bor-2026.vol40.003","DOIUrl":"10.1590/1807-3107bor-2026.vol40.003","url":null,"abstract":"<p><p>Dental caries remains a significant public health issue, particularly among children from low-income areas, where limited access to preventive and restorative care increases the disease burden. In Costa Rica, recent data on the prevalence of caries in children under seven years of age are lacking. This nationwide study aimed to determine the prevalence and severity of dental caries lesions in Costa Rican children aged 12-81 months living in poverty and enrolled in the Centers for Education and Nutrition and Comprehensive Child Nutrition and Care Centers (CEN-CINAI), which are national childcare and nutrition programs. A cross-sectional descriptive study was conducted with 800 children from urban and rural areas. The probability-proportional-to-size (PPS) method was used to select 40 centers, with systematic random sampling of 25 children per center. Clinical examinations were performed by eight calibrated examiners following the International Caries Detection and Assessment System (ICDAS) criteria to assess oral health conditions. The inter- and intraexaminer kappa values ranged from 0.80-0.93. The overall prevalence of caries lesions was 84.81% (ICDAS codes 1-6), with 47.19% of the participants presenting moderate-to-severe carious lesions (ICDAS codes 3-6). The highest prevalence was observed in the 37-48-month age group (91.45%). Differences in the prevalence of caries by sex were more evident in younger age groups and minimal in the older age groups. Only 28.75% of the children with caries had received restorative treatment. The 37-48-month age group presented the highest prevalence of caries, with most lesions being moderate to severe and treatment coverage remaining low.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e003"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of root canal treatment on oral health-related quality of life: a prospective cohort study.","authors":"Ludmila Silva Guimarães, Erlange Andrade Borges da Silva, Fernanda Garcias Hespanhol, Marcelo Levin Cidade D'Amato Tavares, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes","doi":"10.1590/1807-3107bor-2025.vol39.126","DOIUrl":"10.1590/1807-3107bor-2025.vol39.126","url":null,"abstract":"<p><p>The objective of this study was to assess the impact of root canal treatment (RCT) in single-rooted teeth with asymptomatic apical periodontitis on oral health-related quality of life (OHRQoL). As a secondary objective, the impact of factors such as age, gender, ethnicity, tooth groups, arch position, crown destruction, postoperative pain, edema, and use of analgesics after procedure were also noted. A prospective cohort study was designed and enrolled in a sample of 105 patients who needed root canal treatment in single-rooted maxillary or mandibular teeth with asymptomatic apical periodontitis, without preoperative symptoms. RCT was performed in one session. The impact of the OHRQoL was recorded using the Oral Health Impact Profile (OHIP-14) at baseline and after seven and 30 days. Predictor variables were also collected: age, gender, ethnicity, tooth groups, arch position, destruction of the crown, postoperative pain, edema, and the use of analgesics. Data were tabulated and analyzed in SPSS software, with alpha value set at 0.05. All domains of the OHIP-14 questionnaire revealed a statistically significant difference between the times evaluated (p < 0.001), showing the positive impact of the RCT on OHRQoL, with moderate and large effects. There was a significant difference in the total score for gender (p = 0.001), ethnicity (p = 0.010), and crown destruction (p = 0.002). RCT improved OHRQoL scores in all domains assessed by OHIP-14, with moderate and large effects. Factors such as female gender, mixed race and afrodescendant participants, and extensive crown destruction negatively influenced the OHRQoL of patients pre-RCT.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e126"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12683721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145721254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of clinical stage and location of dental caries lesions on oral health-related quality of life.","authors":"Shyrley Díaz, Jenny Abanto, Marcelo Boneckër, J Sebastian Lara, Saul Martins Paiva, Isabel C Olegário","doi":"10.1590/1807-3107bor-2025.vol39.125","DOIUrl":"10.1590/1807-3107bor-2025.vol39.125","url":null,"abstract":"<p><p>Assess the association between dental caries clinical stage, lesion location, and oral health-related quality of life (OHRQoL) in preschool children. A cross-sectional study was conducted with a representative sample of 643 caregiver-child dyads aged 0-5 years. Children underwent oral examinations using the International Caries Detection and Assessment System (ICDAS) and the International Caries Classification and Management System (ICCMS™) criteria to classify caries stage and lesion location. Traumatic dental injuries (TDI) were assessed using Andreasen's classification. Caregivers completed the Early Childhood Oral Health Impact Scale (ECOHIS). Weighted Kappa coefficients assessed intra- and inter-examiner reliability. Negative binomial regression models, adjusted for sociodemographic variables and clinical factors, estimated the association between caries stage/location and ECOHIS scores. The prevalence of dental caries (all stages) was 72.6%, with 27.3% of children caries-free. Overall, 48.2% of caregivers reported at least one oral health impact in their child's life (ECOHIS ≥ 1). Children with extensive lesions (stage C) had significantly worse total and domain ECOHIS scores than caries-free children (p < 0.001), regardless of lesion location. Moderate lesions (stage B) affected OHRQoL only when present in both anterior and posterior teeth (RR = 1.54; p = 0.045). Older age, public school attendance, and household crowding were also associated with poorer OHRQoL. The presence of TDI was independently associated with poorer OHRQoL (RR = 1.63; p < 0.001). These findings highlight the need for targeted, patient-centred interventions to address caries burden effectively.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e125"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12683720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145721275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of CD68, CD4, TNF-α, and COX-2 expression on disease-specific survival in Brazilian patients with OSCC.","authors":"Sibele Nascimento de Aquino, Lucas Lacerda de Souza, Hélen Kaline Farias Bezerra, Daniel Gomes de Alvarenga, Paulo Rogério Ferreti Bonan, Helder Domiciano Dantas Martins, Alan Roger Santos-Silva, Márcio Ajudarte Lopes, Pablo Agustin Vargas","doi":"10.1590/1807-3107bor-2025.vol39.121","DOIUrl":"10.1590/1807-3107bor-2025.vol39.121","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck. Studies on the inflammatory pathways that have evolved during the development of the disease remain controversial. We assessed the expression of inflammatory markers, such as COX (cyclooxygenase)-2, CD68, CD4, and tumor necrosis factor (TNF)-α, based on prognostic variables and disease-specific survival in patients with OSCC. Immunohistochemical analysis of COX-2, TNF-α, CD4, and CD68 was conducted in 72 patients treated surgically. Neural invasion was evaluated based on S100 expression. Disease-specific survival was assessed using Cox regression analysis. Most participants were male, with a mean age of 61 years. A total of 77.5% of patients presented with clinical stages III-IV, and 70% underwent surgery combined with radiotherapy or chemotherapy. The expression of CD68, CD4, and TNF-α was not associated with clinical variables or tumor differentiation. COX-2 expression correlated with tumor size (p = 0.01), whereas high TNF-α expression was noted in moderately/poorly differentiated OSCC. The absence of nodal involvement (hazard ratio [HR]: 0.47, confidence interval [CI]: 0.25-0.87, p = 0.001) was linked to lower death risk, whereas surgery without adjuvant radiotherapy or chemotherapy was associated with a higher risk of death (HR: 2.09, 95%CI: 1.02-4.27, p = 0.043). Multivariate analysis revealed that high COX-2 expression predicted a shorter disease-specific survival. Altogether, high TNF-α expression is prevalent in moderately/poorly differentiated OSCC, and elevated COX-2 expression correlates with larger tumor size and poorer survival in OSCC.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e121"},"PeriodicalIF":1.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12628726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental pain among children aged 8 to 11 and associated factors: a population-based study.","authors":"Taiane Oliveira Souza, Luana Leal Roberto, Nathalia Geovana Corrêa Ruas, Débora Souto-Souza, Paula Cristina Pelli Paiva, Maria Letícia Ramos-Jorge","doi":"10.1590/1807-3107bor-2025.vol39.120","DOIUrl":"10.1590/1807-3107bor-2025.vol39.120","url":null,"abstract":"<p><p>This study aimed to identify factors associated with dental pain among schoolchildren in Diamantina, Minas Gerais, Brazil. A total of 627 children aged 8-11 years were assessed through questionnaires and clinical examinations in both public and private schools. We employed a complex, probabilistic, two-stage cluster sampling method involving schools and classes. The sample size was calculated assuming a 50% prevalence of events or diseases, a 95% confidence level, a 5.0% margin of error, a design effect (deff) of 1.5, and a 15% non-response rate. The dependent variable, dental pain, was assessed by asking: \"Have you ever had a toothache in your life?\" with possible responses of \"No\" or \"Yes.\" The independent variables included sociodemographic factors and dental history. Binary logistic regression was used to estimate the odds ratio (OR). Approximately 70.6% of the children reported having experienced dental pain at least once in their lives. In the final model, the likelihood of having experienced dental pain was higher among children who had either deciduous or permanent teeth restored (OR = 1.99; 95%IC: 1.19-3.29), who had a normative need for dental treatment (OR = 3.00; 95%IC: 1.96-4.58), and whose guardians perceived their oral health negatively (OR = 1.81; 95%IC: 1.19-2.75). Dental pain is a significant oral health issue among children. This pain was associated with both unfavorable normative assessments and subjective perceptions of oral health, underscoring the importance of preventive and promotive strategies for children's oral health.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e120"},"PeriodicalIF":1.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12628737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sugar consumption and early childhood caries: a systematic review and meta-analysis of cohort studies.","authors":"Mariana Silveira Echeverria, Fernanda Burkert Mathias, Helena Silveira Schuch, Maximiliano Sérgio Cenci, Marcos Britto Correa, Marie-Charlotte Huysmans, Flávio Fernando Demarco","doi":"10.1590/1807-3107bor-2025.vol39.122","DOIUrl":"10.1590/1807-3107bor-2025.vol39.122","url":null,"abstract":"<p><p>The aim of this systematic literature review and meta-analysis was to answer the following research question: \"Is sugar consumption associated with early childhood caries among children under 6 years of age in cohort studies?\". The following electronic databases were accessed from December 2020 to May 2025 to identify the existing literature: Bireme, Pubmed/Medline, Scielo, Scopus, and Web of Science. Studies considered eligible for this systematic review were those that investigated sugar consumption as the main exposure and early childhood caries (ECC) as the outcome. Study selection and data extraction were performed independently by two reviewers. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist for cohort studies scale. The search strategy retrieved 718 studies. After title and abstract screening, 59 were selected for full-text review, leading to the inclusion of 17 original studies in this systematic review. Finally, nine studies provided sufficient data for a meta-analysis. The association between sugar consumption and ECC was consistent across most of the cohort studies included in this review, which reported that higher sugar consumption was associated with higher prevalence of dental caries. The pooled effect estimate from the meta-analysis yielded an OR of 1.59 and a 95% CI (1.50-1.68), indicating that children who consumed sugar in early childhood were 59% more likely to develop caries compared to those who did not consume sugar. The included studies had a low risk of bias. Our systematic review and meta-analysis confirmed the association between sugar consumption and ECC in longitudinal cohort studies.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"39 ","pages":"e122"},"PeriodicalIF":1.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12628725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}