Brazilian oral research最新文献

{"title":"Tissue response and expression of interleukins (IL)-1ß, IL-6, IL-10 after pulp capping with bioglasses in mice.","authors":"Hebertt Gonzaga Dos Santos Chaves, Barbara Figueiredo, Caroline Andrade Maia, Alexandre Henrique Dos Reis-Prado, Maísa Mota Antunes, Ricardo Alves de Mesquita, Warley Luciano Fonseca Tavares, Gustavo Batista Menezes, Ivana Márcia Alves Diniz, Murilo Camuri Crovace, Gleide Fernandes de Avelar, Francine Benetti","doi":"10.1590/1807-3107bor-2024.vol38.0096","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0096","url":null,"abstract":"<p><p>This study aimed to evaluate the pulp response to F18 and cobalt-doped F18 bioglass (F18Co) in comparison with calcium hydroxide (CH) after pulp capping. The maxillary first molars of 48 rats were divided into F18, F18Co, CH, and control (no intervention) groups. The pulp was exposed, the materials were placed, and the teeth were capped. After 7 and 15 days, the animals were euthanized for pulp evaluation and interleukin (IL) expression determination. Statistical analysis was carried out using the SigmaPlot® program (Systat Software Inc., for Windows, version 12.0). The data obtained in the analyses were subjected to the non-parametric Kruskal-Wallis test, followed by Dunn's test. For all tests, statistical significance was set at p < 0.05. The CH group exhibited mild to moderate inflammation, whereas the bioglass groups displayed moderate to severe inflammation, indicating a notable difference between the control and bioglass groups. At 7 days, both the CH and most of the bioglass specimens showed moderate disorganization. On day 15, CH displayed mildto-moderate disorganization, whereas F18 and F18Co exhibited significantly more moderate-to-severe disorganization. There were no significant differences in IL-6 and IL-10 expressions between groups at 7 days, but a noteworthy increase in IL-1β was observed in both CH and F18. After 15 days, there was a greater expression of IL-6 and IL-1β in the bioglass groups. No significant IL-10 expression was observed. Bioglass performed less effectively than CH when in direct contact with the pulp tissue.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e096"},"PeriodicalIF":1.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mouth breathing is associated with a higher prevalence of anterior dental caries in preschool children.","authors":"Maria Eliza da Consolação Soares, Joana Ramos-Jorge, Laura Jordana Santos Lima, Luana Viviam Moreira, Izabella Barbosa Fernandes, Maria Letícia Ramos-Jorge, Rodrigo Galo","doi":"10.1590/1807-3107bor-2024.vol38.0057","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0057","url":null,"abstract":"<p><p>This cross-sectional study aimed to investigate the association between anterior dental caries and the predominant type of breathing in preschoolers. The research involved a sample of 257 children aged between 3 and 5 years, who were enrolled in public daycare centers and preschools in the city of Diamantina, MG, Brazil. A questionnaire was applied to parents/guardians to collect sociodemographic data, habits, oral health, and a dietary diary used to calculate the Sucrose Consumption Index. The predominant type of breathing, whether nasal or through the mouth, was determined through direct observation. Dental caries was assessed using the International Caries Detection and Assessment System (ICDAS). Descriptive analyses and the Poisson regression were conducted to analyze the data. The results revealed a higher prevalence of anterior dental caries among children who predominantly breathed through the mouth (PR = 1.57; 95%CI: 1.01-2.46; p = 0.047), who exhibited a higher frequency of sucrose consumption (PR = 4.02; 95%CI: 2.03-7.95; p < 0.001), and had mothers with lower educational levels (PR = 1.53; 95%CI: 1.01-2.32; p = 0.043). Pacifier use was associated with a lower prevalence of anterior dental caries (PR = 0.57; 95%CI: 0.34-0.96; p = 0.035). In conclusion, this investigation demonstrated an association between carious lesions in the anterior teeth and predominantly mouth breathing in preschoolers.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e057"},"PeriodicalIF":1.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue behavior of sintered, glazed and glass-infiltrated surfaces of 5Y-PSZ bonded plates.","authors":"Ana Carolina da Silva, Laura Patrícia Nadal Ortiz, Larissa Márcia Martins Alves, Kiara Serafini Dapieve, Tiago Moreira Bastos Campos, Marco Antonio Bottino, Gilmar Patrocínio Thim, Luiz Felipe Valandro, Renata Marques de Melo Marinho","doi":"10.1590/1807-3107bor-2024.vol38.0027","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0027","url":null,"abstract":"<p><p>This study evaluated the effect of different occlusal surface finishes (glaze and silica glass infiltration) on surface characteristics and fatigue behavior of partially stabilized zirconia (PSZ) plates adhesively bonded onto epoxy resin discs. PSZ disc specimens (n = 15; Katana blocks STML, Kuraray Noritake Dental) were produced (Ø = 10 mm; thickness = 1.2 mm) and allocated into 3 groups: As sintered (S), silica glass infiltration (SGI), and glaze application (G). The PSZ intaglio surface was air-abraded with 50-µm alumina powder followed by bonding agent application. All produced PSZ were adhesively cemented onto dentin analogue discs made of epoxy resin material (Ø = 10 mm; thickness = 2 mm). Step stress fatigue test was performed (load ranging from 200 to 1800 N; step size 100 N and 10,000 cycles; 20 Hz). The topographic, microstructural, and fractographic analyses were performed by scanning electron microscopy. Results: No statistically significant difference in fatigue behavior was detected among the groups. All failures started at the bonding surface. Silica glass-infiltration and glaze layer application provided a smoothing effect, while the sintered group had a surface with grooves. The occlusal surface finishing method (silica glass infiltration or glazing) had no deleterious effect on fatigue behavior of adhesively bonded PSZ plates.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e027"},"PeriodicalIF":1.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoral appliance treatment modulates inflammatory markers and oxidative damage in elderly with sleep apnea.","authors":"Alessandra Peres, João Carlos Fraga da Rosa, Joane Severo Ribeiro, Sofia de Lima Silva, Cristiane Bündchen, Gilson Pires Dornelles, Vania Fontanella","doi":"10.1590/1807-3107bor-2024.vol38.0084","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0084","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) causes intermittent hypoxia, increased production of reactive oxygen species, and inflammation, which may elevate morbidity and mortality from cardiovascular disease. The objective of the present study was to investigate the effect of the intraoral appliance (IOA) as a treatment for OSA when it comes to the modulation of inflammatory markers and oxidative damage in elderly individuals. This \"before and after\" clinical trial included 9 patients diagnosed with OSA recruited from a multicenter randomized clinical trial study that evaluated the treatment with IOA for 60 days. Demographic and anthropometric variables, apnea and hypopnea index (AHI), and oxygen desaturation index (ODI) were collected by type III polysomnography, Epworth Sleepiness Scale, and inflammatory and oxidative damage markers (interleukin 6 (1L-6); tumor necrosis factor α (TNF-α); interleukin 10 (IL-10); thiobarbituric acid reactive substances (TBARS); total thiols; advanced oxidation protein products (AOPP), and nitric oxide (NO)). Shapiro-Wilk test, paired t-test and Pearson's correlation tests were used to analyze the results, respectively (α=0.05). The sample had a mean age of 71.86 ± 4.63 years, the majority were women (55.55%), and had a significant reduction in AHI (p=0.003), ODI (p=0.038), IL-10 (p=0.0001), AOPP (p=0.038) and TBARS levels (p=0.0001). There was a significant correlation between IL-10 and NO (r=0.855) and between TBARS and IL-6 (r=0.669), both after treatment. This study demonstrated that treating elderly patients with OSA using an IOA for 60 days reduces oxidative damage through the modulation of AOPP and TBARS.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e084"},"PeriodicalIF":1.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro reduction of enamel erosion by sugarcane-derived cystatin associated with sodium trimetaphosphate.","authors":"Carolina Ruis Ferrari, Karolyne Sayuri de Araujo Kitamoto, Vinicius Taioqui Pelá, Éven Akemi Taira, Tamara Teodoro Araújo, Larissa Tercilia Grizzo Thomassian, Flávio Henrique-Silva, Juliano Pelim Pessan, Marília Afonso Rabelo Buzalaf","doi":"10.1590/1807-3107bor-2024.vol38.0124","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0124","url":null,"abstract":"<p><p>The objective of this in vitro study was to assess the efficacy of CaneCPI-5, either alone or in combination with various concentrations of sodium trimetaphosphate (TMP) in protecting against initial enamel erosion. A total of 135 bovine enamel specimens were prepared and categorized into nine groups (n/group=15) according to the following treatments: Deionized water; Commercial solution (Elmex Erosion ProtectionTM); 0.1 mg/mL CaneCPI-5; 0.5% TMP; 1.0% TMP; 3.0% TMP; 0.1 mg/mL CaneCPI-5+0.5% TMP; 0.1 mg/mL CaneCPI-5+1.0%TMP; and 0.1 mg/mL CaneCPI-5+3.0%TMP. The specimens were treated with the respective solutions for 2 h, followed by acquired enamel pellicle formation for 2 h and exposure to 0.65% citric acid (CA) for 1 min. These procedures were repeated once a day for three consecutive days. Demineralization was assessed by the percentage change in surface hardness (%CSH) and calcium release into CA, analyzed by the Arsenazo III method. The data were evaluated using Kruskal-Wallis/Dunn's tests. Regarding %CSH, CaneCPI-5+3.0%TMP was the most effective treatment when compared to the CaneCPI-5 group alone. As for calcium release into CA, the CaneCPI-5+0.5% TMP and CaneCPI-5 groups (both with lower calcium release) did not significantly differ from the commercial solution. In conclusion, combination of CaneCPI-5 with TMP enhances the protective potential against initial enamel erosion in vitro.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e124"},"PeriodicalIF":1.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Municipality-level characteristics associated with very good quality water fluoridation in Brazil in 2018.","authors":"Lorrayne Belotti, Camila de Moraes Paulino, Paulo Frazão","doi":"10.1590/1807-3107bor-2024.vol38.0082","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0082","url":null,"abstract":"<p><p>The aim of this study was to analyze factors associated with the quality of fluoridation in water supply systems in Brazil in 2018. An ecological study was conducted using official data sources on fluoridation provision and fluoride concentration surveillance in 2018. Inclusion criteria were municipalities with a water supply system and accurate data. Municipalities meeting the quality standard, defined as having 80% or more of water samples within the optimal level for caries prevention were classified as \"very good\" fluoridation quality. Independent variables encompassed structural aspects, socioeconomic factors, and indicators of managerial and technical capabilities in water surveillance. Prevalence ratios were estimated using Poisson regression with robust variance. A total of 58.9% of municipalities with water supply systems had fluoride-adjusted water, with 65.3% adequately contributing to the surveillance data system. Among these, 42.2% exhibited \"very good\" fluoridation quality. Quality was higher in larger municipalities with elevated socioeconomic indexes and per capita expenditure on sanitary surveillance above the median. Additionally, municipalities with a conformity rate of free residual chlorine concentration of 75% or higher had better fluoridation quality. After adjusting for all variables, fluoridation quality was lower in municipalities with above-median per capita gross domestic product, higher socioeconomic inequality, and below-median monthly household per capita income. Fluoridation quality was linked to municipality-level characteristics concerning structural aspects, socioeconomic factors, and managerial and technical factors in water surveillance. The information generated regarding the coverage features of surveillance and fluoridation strategies can be highly valuable for redirecting inter-sectoral public policy management.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e082"},"PeriodicalIF":1.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial.","authors":"Karla Pinheiro de Alencar, Daniel Fernandes Peixoto, Fábio do Nascimento Máximo, Isabela Albuquerque Passos Farias, Fábio Correia Sampaio","doi":"10.1590/1807-3107bor-2024.vol38.0107","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0107","url":null,"abstract":"<p><p>The aim of this study was to evaluate in vivo dental biofilm acidogenicity induced by nine long-term pediatric oral liquid medications (OLMs). A double-blind crossover randomized clinical trial was conducted with 12 individuals aged 18 to 22 years who had good oral hygiene (OSI < 1.1) and a DMFT index of less than 12. Each participant was exposed to nine OLMs and a 10% sucrose solution (positive control) as part of the crossover design. The pH of the dental biofilm was measured with a Beetrode® microelectrode at 0, 5, 10, 15, 20, 25, and 30 min. Statistical analysis was performed to determine the minimum pH and the area under the curve (AUC). One-way ANOVA was utilized, and the significance level was set at 0.05. Pediatric OLMs caused a sucrose-like decrease in biofilm pH, regardless of therapeutic class (p > 0.05). The mean ± standard deviation of the AUC ranged from 16.26 ± 11.59 (cetirizine) to 39.22 ± 20.81 (azithromycin), with no statistically significant difference compared to sucrose (25.22 ± 6.97) (p > 0.05). The findings suggest that pediatric OLMs contribute to dental biofilm acidogenicity, with a more pronounced effect induced by medications used for respiratory diseases and also by antibiotics.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e107"},"PeriodicalIF":1.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial morphology analysis of Caucasian Brazilian adult women using stereophotogrammetry.","authors":"Maria Gabriela Robles Mengoa, Amanda Aparecida Maia Neves Garcia, Karolyn Sales Fioravanti, Karin Hermana Neppelenbroek, Thaís Marchini Oliveira, Chiarella Sforza, Simone Soares","doi":"10.1590/1807-3107bor-2024.vol38.0105","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0105","url":null,"abstract":"<p><p>This cross-sectional observational study aimed to evaluate and compare facial metrics in women aged 20-65 years using a three-dimensional (3D) stereophotogrammetry system and to establish standardized values for facial metric variations in different age subgroups. This study included 84 Caucasian women divided into two groups based on their age: group 1 (G1) included women aged 20-40 years and group 2 (G2) included women aged 41-65 years. Twenty-one morphometric points on the face were identified, and the facial images were captured using a 3D stereophotogrammetry system, Twenty-three linear measures and 12 angular measures were evaluated, revealing statistically significant differences in 11 linear and 5 angular measures between the groups. In the G2 group, nasal and mouth width, lip philtrum height, Tragus-Nasion and Tragus-Pronasale lengths were increased, along with increased nasofrontal angle, decreased palpebral fissure inclination, and lip vermilion angles. However, palpebral fissure width and height, binocular width, and lip vermilion height were reduced. The aging process in women causes substantial changes in facial features, particularly in the middle and lower thirds of the face. Conversely, no major changes were observed in the upper third of the face. Our study findings provide potential insights for clinicians in developing facial rejuvenation procedures as well as for forensic purposes and surgical planning. The standardized facial metrics values in different age subgroups can guide clinicians in determining appropriate treatment plans for patients seeking facial rejuvenation.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e105"},"PeriodicalIF":1.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the analgesic efficacy of spray and tablet flurbiprofen for pain after soft tissue surgery.","authors":"Cennet Neslihan Eroglu, Mehmet Nuri Yuksek, Sadi Elasan, Yusuf Rodi Mizrak, Busra Karaca","doi":"10.1590/1807-3107bor-2024.vol38.0108","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0108","url":null,"abstract":"<p><p>The aim of this randomized clinical study was to assess the comparative efficacy of flurbiprofen in tablet and spray formulations for postoperative pain management in oral soft tissue wounds undergoing primary closure while investigating the feasibility of achieving optimal analgesia with reduced dosage and risk. Forty patients who underwent epulis fissuratum and frenulum excision for pre-prosthetic surgery were randomly assigned to receive either tablet or spray forms of flurbiprofen. The lesion dimensions were measured preoperatively, followed by excision and primary closure. The tablet group received oral tablets containing 100 mg of flurbiprofen twice daily, whereas the spray group received an oral spray containing 0.25% flurbiprofen, administered as two sprays thrice daily. Postoperative pain was assessed using the Numerical Rating Scale (NRS) until the 7th day. Lesion size, drug consumption, and rescue analgesic use were compared between the groups. There were no statistically significant differences in the lesion size between the groups. However, the mean NRS score in the spray group was significantly lower in the spray group compared to than that in the tablet group at 6th hour postoperatively (p = 0.037). Significant differences favoring the tablet group were observed in the first three doses of the drug (p = 0.001). No patients required rescue analgesics. The spray formulation of flurbiprofen demonstrated effective and safe pain relief in oral soft tissue wounds undergoing primary closure, with no reported adverse effects.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e108"},"PeriodicalIF":1.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Brazilian hospital and healthcare service infrastructure for cleft lip and palate patients.","authors":"Raquel Souto Silva, Rosa Núbia Vieira de Moura, Daniele Lopes Leal, Soraia Macari, Marcos Azeredo Furquim Werneck, Rafaela da Silveira Pinto","doi":"10.1590/1807-3107bor-2024.vol38.0103","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0103","url":null,"abstract":"<p><p>Cleft lip and palate (CLP) represent the most frequently reported congenital anomaly affecting the craniofacial region. The aim of this study was to assess the output (in number of procedures) of the Brazilian hospitals accredited for the treatment of CLP patients, examine the referral flow of patients requiring this type of care, and ascertain the adequacy of the corresponding infrastructure of these healthcare facilities. Methodologically, the study used an observational, cross-sectional, and ecological design. Output data, categorized by state and macro-region, and patient referral flow records were accessible through the Outpatient Information System (SIA, in its Portuguese acronym) and the Hospital Information System (SIH, in Portuguese), respectively. Infrastructure assessment relied on data sourced from the National Register of Health Establishments (CNES, in Portuguese). Analysis encompassed data from 28 accredited hospitals. Concerning output metrics, the state of São Paulo ranked first in the number of procedures conducted. The establishments exhibiting the lowest output performance comprised six hospitals located in the Southeast region and two in the Center-West region. Examination of patient referral flow corroborated the concentration of procedures predominantly conducted in the Southeast, notably within São Paulo state. Infrastructure evaluation encompassed the following categories: physical facilities, diagnostic and therapeutic support services, equipment, and comprehensive multidisciplinary care services. The data showed that roughly 61% of the hospitals surveyed possessed less than half of the recommended items. The primary deficiency identified pertained to inadequacies in equipment availability. Conversely, the best outcomes were associated with diagnostic and therapeutic support services. It was concluded that enhancing hospital infrastructure is imperative for the amelioration of care provision to patients with CLP across all Brazilian states.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e103"},"PeriodicalIF":1.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}