Brazilian oral research最新文献

{"title":"Evidence-based approaches for advancing clinical research and practice: dentistry beyond the myth.","authors":"Lucianne Cople Maia","doi":"10.1590/1807-3107bor-2026.vol40suppl1057","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1057","url":null,"abstract":"","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e057"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than a trend: the rationale for using bioactive materials in clinical practice.","authors":"Igor Paulino Mendes Soares, Maria Luiza Barucci Araújo Pires, Juliana Rios de Oliveira, Lídia de Oliveira Fernandes, Carlos Alberto de Souza Costa, Marco Cícero Bottino, Josimeri Hebling","doi":"10.1590/1807-3107bor-2026.vol40suppl1060","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1060","url":null,"abstract":"<p><p>The concept of bioactivity in restorative dentistry has evolved beyond the traditional expectation of inert materials designed solely to replace lost tooth structure. Contemporary restorative systems are increasingly engineered to interact with the dentin-pulp complex by modulating mineral dynamics, matrix stability, and cellular responses. However, misconceptions remain regarding what restorative \"bioactivity\" can realistically achieve in clinical practice. This review critically discusses the biological basis and clinical relevance of bioactive materials in restorative dentistry, emphasizing dentin-pulp preservation and the distinction between validated bioactivity and laboratory observations. Bioactivity may arise through physicochemical mechanisms, such as ion release, pH modulation, and mineral precipitation, which may contribute to mineral recovery and dentin-pulp preservation, although many proposed effects remain insufficiently validated clinically. In parallel, biological mechanisms involve modulation of odontogenic signaling, pulp cell differentiation, and extracellular matrix dynamics. Strategies targeting collagen stability, including cross-linking, protease inhibition, and intrafibrillar mineralization, may also improve hybrid-layer durability and interfacial longevity. Beyond dentin-focused interventions, pulp-directed bioactivity includes clinically established vital pulp therapy materials and emerging scaffold-based regenerative systems that remain largely investigational. However, important translational questions remain regarding the clinical functionality of current materials. Clinically relevant restorative bioactivity should not be defined by ion release or surface mineral deposition alone, but by the ability of materials to preserve dentin-pulp homeostasis and long-term restorative stability. Moving beyond the \"bioactive\" label requires evidence-based strategies that sustain dentin-pulp homeostasis rather than merely replacing lost structure.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e060"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation in the management of oral lesions: a targeted, evidence-based approach.","authors":"Valesca Sander Koth, Amanda de Farias Gabriel, Iohanna Deckmann, Rogerio Moraes Castilho, Felipe Nor, Marcelo Lazzaron Lamers, José Antonio Poli de Figueiredo, Manoela Domingues Martins","doi":"10.1590/1807-3107bor-2026.vol40suppl1059","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1059","url":null,"abstract":"<p><p>This review synthesizes current literature on laser applications in dentistry, with particular emphasis on the biological mechanisms of photobiomodulation (PBM), dosimetric considerations, tissue interactions, and the clinical management of the most prevalent oral lesions. The oral disorders most frequently investigated for the therapeutic use of PBM were: a) oral pain conditions: trigeminal neuralgia, temporomandibular disorders, and burning mouth syndrome; b) oncology-related conditions: oral mucositis and hyposalivation; c) immune-mediated disorders: recurrent aphthous stomatitis and oral lichen planus; and d) viral infections: herpes labialis. A wide range of laser parameters has shown clinical benefits in the treatment of these disorders. These outcomes are attributed to the anti-inflammatory, analgesic, and tissue repair effects of PBM, which may occur immediately and cumulatively over repeated sessions. PBM therapy is a valuable therapeutic resource in contemporary dentistry and may be successfully applied in a wide range of clinical conditions. Clinical effectiveness of PBM depends on appropriate dosimetry and irradiation parameters according to the biological characteristics of each condition and therapeutic target. Therefore further well-designed randomized clinical trials and protocol standardization are still required to strengthen clinical recommendations and optimize reproducibility.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e059"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of panoramic radiography, periapical radiography, and CBCT in diagnosing apical root resorption.","authors":"Francieli Regina Bortoli, Filipe Colombo Vitali, Marcio Correa, Roberto Rocha, Fabrício Augusto Menegon, Leticia Fernanda Haas, Lucas da Fonseca Roberti Garcia, Cleonice da Silveira Teixeira","doi":"10.1590/1807-3107bor-2026.vol40.069","DOIUrl":"10.1590/1807-3107bor-2026.vol40.069","url":null,"abstract":"<p><p>This study evaluated the accuracy of digital panoramic radiography, digital periapical radiography, and cone-beam computed tomography (CBCT) in diagnosing apical root resorption (ARR) using 85 extracted teeth from dry human skulls and mandibles. Four ARR levels were simulated: mild, moderate, severe, and extreme. CBCT scans, panoramic radiographs, and periapical radiographs were obtained before and after ARR simulation. Three examiners independently evaluated all images to determine ARR and, when present, to classify its severity level. Inter- and intra-observer agreement was calculated using Cohen's kappa, and sensitivity, specificity, and accuracy were determined for each method. Receiver operating characteristic (ROC) curve analysis was performed to obtain the area under the curve (AUC). AUCs were compared using the DeLong test. All imaging methods showed substantial inter- and intra-examiner agreement (κ > 0.60). CBCT demonstrated the highest sensitivity, specificity, and accuracy, followed by periapical and panoramic radiography. CBCT was significantly superior (p < 0.01) in detecting mild (AUC = 0.939) and moderate (AUC = 0.947) ARR compared with the other methods (AUC < 0.877). For severe ARR, CBCT (AUC = 0.953) and periapical radiography (AUC = 0.921) performed similarly (p > 0.05) and were superior (p=0.03) to panoramic radiography (AUC = 0.874). For extreme ARR, no significant difference was observed among the methods. In conclusion, CBCT showed high accuracy in detecting ARR, particularly at milder levels (< 2 mm). Periapical radiography was comparable to CBCT for severe resorption (one-third of the root), while all methods performed similarly for extreme resorption (half of the root). Thus, CBCT appears most suitable for early ARR detection, whereas periapical and panoramic radiography are adequate for diagnosing advanced stages.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e069"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key concepts for clinical management of Molar Incisor Hypomineralization.","authors":"Aline de Almeida Neves, Lourdes Santos-Pinto, Daniela Rios, Vera Mendes Soviero","doi":"10.1590/1807-3107bor-2026.vol40suppl1061","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1061","url":null,"abstract":"<p><p>Clinical management of patients with molar incisor hypomineralization (MIH) requires a comprehensive and multidimensional assessment that integrates clinical, behavioral, radiographic, functional, and psychosocial parameters. This article discusses key aspects of MIH management, including diagnosis and severity grading; non-invasive strategies aimed at preventing enamel breakdown; restorative management of severely affected molars, including the role of timed extractions; esthetic treatment to mask opacities in anterior teeth; and desensitizing approaches for the management of hypersensitivity. The literature for this narrative review was identified through targeted searches in PubMed for classic and recent publications on the clinical management of MIH. Reference lists of relevant articles were also hand-searched to identify additional relevant studies. Finally, future perspectives and emerging directions in MIH management are discussed.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e061"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between TMD signs and symptoms, condyle alterations and joint effusion: an MRI retrospective study.","authors":"Jhonatan Thiago Lacerda-Santos, Gélica Lima Granja, Gabriela Dias Prado, Janaina Araújo Dantas, Paulo Sérgio Flores Campos, Patrícia Meira Bento, Daniela Pita de Melo","doi":"10.1590/1807-3107bor-2026.vol40.070","DOIUrl":"10.1590/1807-3107bor-2026.vol40.070","url":null,"abstract":"<p><p>This study aimed to assess whether signs, symptoms, and condylar changes are associated with temporomandibular joint (TMJ) effusion. An observational, cross-sectional, retrospective study was carried out on 1,182 TMJ magnetic resonance imaging (MRI) scans from 591 patients. Images of patients who underwent MRIs of the temporomandibular joints were included. The MRIs were obtained from the records of a private radiology clinic and were acquired in 2018. Two calibrated observers assessed effusion and condylar changes. The evaluated signs and symptoms were joint pain, crepitation, clicking, irregular mouth opening movement, and limited mouth opening. Descriptive statistics were performed, followed by unadjusted and adjusted binary logistic regression analyses to calculate the odds ratio (OR) and 95% confidence interval (95%CI), with a significance level of p ≤ 0.05. The analysis of the variables was performed using the individual as the unit of grouping, with clustered robust standard errors (using the Huber-White estimator) adjusted at the patient level. The prevalence of effusion was over 51% in the studied sample (51.6% right TMJ; 52.8% left TMJ). The most prevalent condylar alterations were condylar erosion and limited condyle width. In the final model, patients aged 50 to 59 years (OR: 2.54; 95%CI: 1.17-5.50), those with clicking (OR: 1.59; 95%CI: 1.07-2.37) and those with condylar erosion (OR: 2.84; 95%CI: 1.56-5.28) were more likely to have joint effusion. It is concluded that joint effusion has a high prevalence in individuals aged 50-59 years, followed by those aged 20 to 29 years, and may be associated with the presence of clicking and condylar erosion.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e070"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domains of Miswak practice among Malaysian Dental Educators: insights from a focus group discussion.","authors":"Muhd Firdaus Che Musa, Noorhazayti Ab Halim, Farah Natashah Mohd, Widya Lestari, Galvin Sim Siang Lin, Mohamad Shafiq Mohd Ibrahim","doi":"10.1590/1807-3107bor-2026.vol40.071","DOIUrl":"10.1590/1807-3107bor-2026.vol40.071","url":null,"abstract":"<p><p>This study aimed to explore dental educators' perceptions of the domains influencing the practice of miswak among dental educators. Dental educators from the International Islamic University Malaysia, representing diverse socio-religious backgrounds, participated in focus group discussions (FGDs) guided by a pre-tested topic framework. The discussions were audio-recorded, transcribed, and analyzed using the framework analysis approach. A total of 11 dental educators participated in four FGD sessions conducted. The analysis identified four interrelated domains influencing miswak practice: self-care, conventional teaching, research evidence, and political or policy context. Participants described miswak primarily as a culturally and religiously embedded oral hygiene practice, while also highlighting uncertainties regarding its integration into the dental education due to limited curriculum guidance and perceived gaps in evidence dissemination. Some participants argued that their Western-oriented dental training also influenced how miswak is perceived within the education system. Overall, the findings suggest that educators' education and training background, together with their levels of knowledge and awareness, shape perceptions of miswak and influence its acceptance within dental education and practice. Further research may help inform educational guidance to support the appropriate integration of Miswak as a complementary oral hygiene practice.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e071"},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative endodontics: current concepts, clinical challenges, and emerging therapies.","authors":"Patricia de Andrade Risso, Ana Paula Portes-Zeno, Alexandre Guimarães Dos Santos, Alice Corrêa Silva-Sousa, Rodrigo Arruda-Vasconcelos, Emmanuel João Nogueira Leal Silva, Carla Renata Sipert","doi":"10.1590/1807-3107bor-2026.vol40suppl1063","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1063","url":null,"abstract":"<p><p>Regenerative endodontics has transformed the management of immature necrotic teeth by offering the potential to improve root structure rather than merely induce apical closure. Over the past two decades, considerable progress has been made in case selection, disinfection protocols, irrigation strategies, intracanal medicaments, scaffold design, and biologically based tissue engineering approaches. Despite these advances, key challenges remain, including protocol standardization, variability in clinical outcomes, limited high-quality clinical evidence, and the gap between promising laboratory findings and routine clinical implementation. This narrative review summarizes the recent literature on regenerative endodontics, focusing on contemporary clinical protocols and their limitations, prognostic factors, treatment outcomes, and emerging therapeutic strategies. Current evidence supports regenerative procedures that involve careful case selection, appropriate scaffold formation, well-sealed coronal restorations, and effective disinfection that preserves stem cell viability. While these protocols promote infection control, periapical healing, and tooth survival, continued root maturation remains variable, and existing therapies primarily result in tissue repair rather than true regeneration of a functional pulp-dentin complex. Additionally, there are several limitations to the widespread clinical adoption of advanced regenerative therapies, including outcome measures, alongside regulatory, manufacturing, and logistical challenges. Bridging the gap between innovation and clinical practice will require continued advances in tissue engineering, as well as more robust clinical evidence and standardized treatment protocols.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e063"},"PeriodicalIF":1.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-cigarettes and periodontal health: current evidence and research gaps.","authors":"Claudio Mendes Pannuti, Thaís Emilia da Silva, Sabrina Garcia de Aquino, João Paulo Steffens, Gustavo Giacomelli Nascimento, Fabio Renato Manzolli Leite","doi":"10.1590/1807-3107bor-2026.vol40suppl1064","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1064","url":null,"abstract":"<p><p>Cigarette smoking is a well-established risk factor for periodontitis, contributing to increased clinical attachment loss (CAL), alveolar bone loss, and impaired treatment response. As electronic cigarettes (ECs) are increasingly used as alternatives to combustible tobacco, questions remain regarding their adverse effects on oral and periodontal health. This critical review integrated evidence from experimental, cross-sectional, longitudinal and interventional studies to evaluate the relationship between EC use and periodontal health. Experimental and molecular studies supported biological plausibility for periodontal harm, indicating that aerosols can induce oxidative stress, upregulate pro-inflammatory mediators, and disrupt host-microbial interactions. Cross-sectional studies generally reported poorer periodontal conditions among EC users compared with never-smokers, including higher plaque index and periodontal probing depth, although results for CAL and alveolar bone loss were inconsistent. Comparisons between EC users and cigarette smokers often showed more favorable clinical parameters among EC users. Longitudinal evidence continued to be limited. The only prospective cohort study reported higher CAL among EC users than never-smokers and observed an increase in CAL over time exclusively in EC users. Interventional studies assessing response to periodontal therapy have yielded inconsistent results, with some suggesting a poorer treatment response among EC users and others finding no significant differences. Overall, there were Well-designed longitudinal studies with clearly defined exposure groups, standardized periodontal outcomes, and longer follow-up are needed to clarify whether EC use independently contributes to periodontal deterioration.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e064"},"PeriodicalIF":1.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical myths in dental bleaching: an evidence-based structured narrative review.","authors":"Alessandra Reis, Bianca Medeiros Maran, Deisy Cristina Ferreira Cordeiro, Laryssa Mylenna Madruga Barbosa, Renata Maria Oleniki Terra, Alessandro Dourado Loguercio, Michael Willian Favoreto","doi":"10.1590/1807-3107bor-2026.vol40suppl1062","DOIUrl":"10.1590/1807-3107bor-2026.vol40suppl1062","url":null,"abstract":"<p><p>This narrative review critically examines common myths in dental bleaching that are often presented as strategies to improve efficacy or reduce adverse effects, despite limited, inconsistent, or context-dependent clinical support. The review integrates evidence from clinical trials and systematic reviews identified through searches, with priority given to higher-level clinical evidence when available. In addition, concepts from Evidence-Based Practice and Cognitive Psychology are used to contextualize why weakly supported protocols may persist in clinical decision-making. The analysis addressed frequently disseminated beliefs in clinical practice and led to the following conclusions: a) dietary restriction does not improve bleaching outcomes; b) preventive use of analgesics and/or anti-inflammatory drugs does not reduce tooth sensitivity (TS); c) higher peroxide concentrations may accelerate early bleaching but increase adverse effects and do not enhance final efficacy; d) prolonged gel exposure beyond recommended times does not produce perceptible additional color change and may increase TS; e) tray scalloping does not consistently reduce patient-perceived gingival irritation; f) increasing gel volume or contact area does not improve final bleaching efficacy and may increase biological cost; g) light-activation does not provide additional clinical benefit; h) gel agitation does not enhance bleaching outcomes; i) over-the-counter products do not replace professionally supervised bleaching in terms of predictability and magnitude of color change; and j) desensitizing toothpastes show inconsistent efficacy in preventing TS. Overall, bleaching protocols should be selected according to clinically meaningful benefits, adverse effects, patient-centered outcomes, and the strength and consistency of the available evidence, rather than tradition, intuition, or commercial appeal.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 suppl 1","pages":"e062"},"PeriodicalIF":1.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}