Brazilian oral research最新文献

The role of social cohesion in gingival bleeding levels among adolescents: a cross-sectional study. 社会凝聚力在青少年牙龈出血水平中的作用：一项横断面研究。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.019

Raiélli Pivetta Moletta, Vitória Baroni, Eduarda da Silveira Borstmann, Jessica Klöckner Knorst, Camila Silveira Sfreddo, Thiago Machado Ardenghi

{"title":"The role of social cohesion in gingival bleeding levels among adolescents: a cross-sectional study.","authors":"Raiélli Pivetta Moletta, Vitória Baroni, Eduarda da Silveira Borstmann, Jessica Klöckner Knorst, Camila Silveira Sfreddo, Thiago Machado Ardenghi","doi":"10.1590/1807-3107bor-2026.vol40.019","DOIUrl":"10.1590/1807-3107bor-2026.vol40.019","url":null,"abstract":"This study aimed to evaluate the relationship between social cohesion and gingival bleeding levels in adolescents from Santa Maria, southern Brazil. This cross-sectional study was nested within a cohort study initiated in 2010 with a representative sample of preschool children aged 1 to 5 years in the city. Participants were re-evaluated at ages 11 and 15 years, resulting in a 10-year follow-up period. The current study used data from this follow-up. Social cohesion was assessed at an individual level through questions about perceptions of neighborhood relationships and the frequency of participation in neighborhood gatherings. Gingival bleeding was evaluated clinically using the Community Periodontal Index (CPI). Sociodemographic and clinical variables were considered as potential confounders. Multilevel adjusted Poisson regression was used to assess associations, and results were expressed as rate ratios (RR) with 95% confidence intervals (95%CI). A total of 429 adolescents were included. In the adjusted model, poor perception of neighborhood relationships was associated with higher gingival bleeding levels (RR = 1.08; 95%CI: 1.03-1.13). Adolescents who did not attend local gatherings had even higher bleeding levels (RR = 1.45; 95%CI: 1.34-1.47). Additionally, non-white adolescents, those with lower income, irregular dental visits, and higher plaque levels also showed greater bleeding. Girls had lower gingival bleeding levels compared to boys. Lower social cohesion, reflected by negative neighborhood perceptions and lack of community participation, was associated with higher gingival bleeding in adolescents. Public health strategies aiming to improve adolescent oral health should focus on strengthening neighborhood relationships and promoting active community engagement as key social determinants.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e019"},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of bioactive restorative materials on cell viability using direct and extract methods. 采用直接法和提取法评价生物活性修复材料对细胞活力的影响。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.017

Zeynep Ekin Kilinc, Vahdi Umut Bengi, Selcuk Savas, Ebru Kucukyilmaz

{"title":"Evaluation of bioactive restorative materials on cell viability using direct and extract methods.","authors":"Zeynep Ekin Kilinc, Vahdi Umut Bengi, Selcuk Savas, Ebru Kucukyilmaz","doi":"10.1590/1807-3107bor-2026.vol40.017","DOIUrl":"10.1590/1807-3107bor-2026.vol40.017","url":null,"abstract":"The biological response of gingival fibroblasts to restorative materials is a key factor in determining the clinical success. This study aimed to evaluate the effects of four restorative materials on the viability of gingival fibroblast cell cultures using a real-time cell analysis system with direct extract methods. Four different restorative materials with bioactive properties were used in this study: Glasiosite (VOCO GmbH, Cuxhaven, Germany), BEAUTIFIL-Bulk Restorative (Shofu Inc., Kyoto, Japan), EQUIA Forte™ HT Fil (GC Corporation, Tokyo, Japan), and Activa BioACTIVE Restorative® (Pulpdent Corporation, Watertown, USA). Disc-shaped specimens were prepared for each material group (n = 18 and n = 9 for each test method). The effects of the materials on gingival fibroblast viability were determined using both direct and extract methods with a real-time cell analysis system (xCELLigence) at two different time periods (24 h and 48 h). A significance level of α = 0.05 was adopted for all statistical analyses. The control group exhibited the highest cell viability, and the differences between the groups were statistically significant at both 24 h and 48 h (p < 0.05). At both 24 h and 48 h, Glasiosite showed the highest cell viability among the tested materials, whereas the BEAUTIFIL-Bulk Restorative exhibited the lowest cell viability (p < 0.05). Cell viability was significantly higher with the extract method than with the direct contact method across all materials, except for the control (p < 0.05). This study revealed that the cell viability varied significantly depending on the material type, exposure time, and test method. Glasiosite showed the highest biocompatibility, while the BEAUTIFIL-Bulk Restorative exhibited the lowest value.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e017"},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of bovine-teeth nanoparticles and its effect on BMP-2 expression in periodontitis rat model. 牛牙纳米颗粒的表征及其对牙周炎大鼠模型BMP-2表达的影响。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.018

Desi Sandra Sari, Shierin Velly Fiolita, Millenieo Martin, Syafika Nuring Fadiyah, Herniyati, Fourier Dzar Eljabbar Latief, Peni Pujiastuti, Yuliana Mahdiyah Da'at Arina, Ernie Maduratna, Haslinda Ramli

{"title":"Characterization of bovine-teeth nanoparticles and its effect on BMP-2 expression in periodontitis rat model.","authors":"Desi Sandra Sari, Shierin Velly Fiolita, Millenieo Martin, Syafika Nuring Fadiyah, Herniyati, Fourier Dzar Eljabbar Latief, Peni Pujiastuti, Yuliana Mahdiyah Da'at Arina, Ernie Maduratna, Haslinda Ramli","doi":"10.1590/1807-3107bor-2026.vol40.018","DOIUrl":"10.1590/1807-3107bor-2026.vol40.018","url":null,"abstract":"Bovine teeth-derived nanoparticles show strong potential in regenerating alveolar bone tissue damaged by periodontitis. They possess osteoinductive and osteoconductive properties that stimulate cell differentiation, proliferation, and extracellular matrix formation. This study characterized nanoparticles from bovine teeth and evaluated their potential for alveolar bone regeneration via particle size analysis, transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray fluorescence (XRF), Brunauer-Emmett-Teller (BET) analysis, micro-computed tomography, and Fourier-transform infrared spectroscopy (FTIR). Twenty Wistar rats were divided into four groups: one control and three treatment groups, which were observed on days 7, 14, and 28. The rats were injected with lipopolysaccharides from Porphyromonas gingivalis to create a model of periodontitis model. Bovine teeth nanoparticles were applied to the periodontal pockets and covered with a periodontal dressing. The particle sizes ranged from 3.67 to 36.75 nm. TEM images revealed that the particles were spherical, while XRD analysis showed that the components consisted of 63% hydroxyapatite and 37% whitlockite. XRF analysis showed that the mineral content was highest in calcium (81.96%) and phosphorus (15.90%). BET analysis indicated that the characteristics of the nanoparticle material were similar to those of commercial bovine bone material. FTIR analysis revealed the presence of hydroxyapatite groups, including -OH, H2O, and P-4. BMP-2 expression levels were notably higher in the repaired bone on day 28 than on days 7 and 14. In conclusion, bovine teeth-derived nanoparticles demonstrate significant potential as biomaterials for alveolar bone regeneration in periodontitis therapy.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e018"},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brightness and contrast adjustments influence proximal caries detection on handheld X-ray radiographs. 亮度和对比度调整影响手持x光片近端龋齿检测。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.016

Débora Costa Ruiz, Marcyele Natane da Silva Morais, Hugo Gaêta-Araujo, Matheus Lima Oliveira, Deborah Queiroz Freitas, Francisco Haiter-Neto

{"title":"Brightness and contrast adjustments influence proximal caries detection on handheld X-ray radiographs.","authors":"Débora Costa Ruiz, Marcyele Natane da Silva Morais, Hugo Gaêta-Araujo, Matheus Lima Oliveira, Deborah Queiroz Freitas, Francisco Haiter-Neto","doi":"10.1590/1807-3107bor-2026.vol40.016","DOIUrl":"10.1590/1807-3107bor-2026.vol40.016","url":null,"abstract":"This study evaluated the influence of brightness and contrast adjustments on the diagnosis of proximal caries lesions in radiographs acquired with a handheld X-ray device. A complementary metal oxide semiconductor sensor (SnapShot, Instrumentarium Imaging, Milwaukee, WI, USA) and a handheld Eagle X-ray device (Alliage, São Paulo, Brazil) were used to acquire radiographs of 20 mandibular molars and 20 mandibular premolars randomly arranged in 20 phantoms. The device settings were 60 kVp, 2.5 mA, and 0.45 seconds of exposure. Brightness and contrast of the resulting radiographs were modified in four combinations: a) -30% brightness and +30% contrast; b) -15% brightness and +15% contrast; c) +15% brightness and -15% contrast; and d) +30% brightness and -30% contrast. After randomization, the original radiographs and the four modified versions were individually assessed by five oral and maxillofacial radiologists to detect proximal caries lesions. The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity were calculated from the examiners' responses and compared with one-way analysis of variance (p<0.05). Intra- and inter-examiner agreement for radiographic diagnosis was assessed using the weighted kappa index. Sensitivity values for detecting proximal caries lesions on radiographs with increased brightness and decreased contrast (+ 30% brightness and -30% contrast) were significantly lower compared with the other combinations (p < 0.05), whereas AUC and specificity values were not influenced by the adjustments tested (p > 0.05). Therefore, increasing brightness and decreasing contrast on radiographs acquired with a handheld X-ray device is not recommended, since it may impair diagnostic accuracy for proximal caries lesions.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e016"},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multicenter study of oral and maxillofacial thrombi: analysis of 187 cases. 口腔颌面部血栓的多中心研究：附187例分析。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.020

Weslay Rodrigues da Silva, Caroline Augusta Belo Faria, Jonathan França da Silva Cavalcanti, Hannah Gil de Farias Morais, Danielle Machado Farias, Isadora Vilas Boas Cepeda, Daniel Augusto Barnabé Nobre, Victor Zanetti Drumond, Bertine Mota Malta Brandão Nunes, Caio César da Silva Barros, Glória Maria de França, Elismauro Francisco de Mendonça, Diego Antonio Costa Arantes, George João Ferreira do Nascimento, Leorik Pereira da Silva, Cyntia Helena Pereira de Carvalho, Jefferson da Rocha Tenório, José Alcides Almeida de Arruda, Bruno Augusto Benevenuto de Andrade, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, Lucas Guimarães Abreu, Elaine Judite de Amorim Carvalho, Danyel Elias da Cruz Perez, Ricardo Alves Mesquita, Hébel Cavalcanti Galvão, Roseana de Almeida Freitas, Ana Paula Veras Sobral

{"title":"Multicenter study of oral and maxillofacial thrombi: analysis of 187 cases.","authors":"Weslay Rodrigues da Silva, Caroline Augusta Belo Faria, Jonathan França da Silva Cavalcanti, Hannah Gil de Farias Morais, Danielle Machado Farias, Isadora Vilas Boas Cepeda, Daniel Augusto Barnabé Nobre, Victor Zanetti Drumond, Bertine Mota Malta Brandão Nunes, Caio César da Silva Barros, Glória Maria de França, Elismauro Francisco de Mendonça, Diego Antonio Costa Arantes, George João Ferreira do Nascimento, Leorik Pereira da Silva, Cyntia Helena Pereira de Carvalho, Jefferson da Rocha Tenório, José Alcides Almeida de Arruda, Bruno Augusto Benevenuto de Andrade, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, Lucas Guimarães Abreu, Elaine Judite de Amorim Carvalho, Danyel Elias da Cruz Perez, Ricardo Alves Mesquita, Hébel Cavalcanti Galvão, Roseana de Almeida Freitas, Ana Paula Veras Sobral","doi":"10.1590/1807-3107bor-2026.vol40.020","DOIUrl":"10.1590/1807-3107bor-2026.vol40.020","url":null,"abstract":"This study aimed to investigate the clinicopathological characteristics of thrombi in the oral and maxillofacial region. A cross-sectional study was conducted in nine reference centers for oral and maxillofacial pathology diagnosis in Brazil, from which biopsy records were obtained. The data were analyzed descriptively. A total of 93,036 biopsies from the oral and maxillofacial region were evaluated, 187 (0.2%) of which were diagnosed as thrombi. The highest occurrence was in females, with a mean age of 52.4 ± 17.7 years. The lip was the most frequently affected anatomical location. A clinical diagnostic hypothesis of thrombus was considered in 4.2% of cases. Oral thrombi were uncommon lesions in the studied population, with a higher occurrence among females in the seventh decade of life. This study provides a clinicopathological profile of oral and maxillofacial thrombi and offers information that may assist clinicians in establishing a diagnosis.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e020"},"PeriodicalIF":1.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between sense of coherence and dental attendance patterns among Brazilian adolescents. 巴西青少年连贯感与牙科就诊模式的关系。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-20 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.006

Leonardo Essado Rios, Maria do Carmo Matias Freire

{"title":"Relationship between sense of coherence and dental attendance patterns among Brazilian adolescents.","authors":"Leonardo Essado Rios, Maria do Carmo Matias Freire","doi":"10.1590/1807-3107bor-2026.vol40.006","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2026.vol40.006","url":null,"abstract":"This study aimed to investigate if sense of coherence (SOC) is associated with dental attendance (DA) patterns among Brazilian adolescent students. A cross-sectional study was conducted in the midwestern region of Brazil. A total of 2,905 adolescents aged 13 to 19 years from 14 public schools in 13 towns/cities in the state of Goiás were included in the study. Data on oral health-related behaviors and psychosocial factors were collected using self-administered questionnaires completed by students during regular school hours. The dependent variables were DA in the past year (yes/no) and the reason for DA (toothache/preventive check-up). SOC was assessed using the Antonovsky's Orientation to Life questionnaire (SOC-13). Adjusted odds ratios (OR) and 95% confidence intervals were estimated using binary logistic regression. Results showed that 56.2% of the students had visited a dentist within the past year, most commonly for a preventive check-up (38.7%). SOC scores ranged from 13 to 91 (mean = 49.3; SD = 12.1). In the regression model adjusted for adolescents' sociodemographic characteristics (age, sex, skin color or race, and maternal education), higher prevalence rates of DA in the past year (OR = 1.02; p < 0.001) and DA motivated by preventive check-ups (OR = 1.02; p < 0.001) were found among those with higher SOC scores. In conclusion, a significant association was found between higher SOC levels and healthier DA patterns among adolescents, regardless of socioeconomic characteristics.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e006"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental anomalies and medical history: prematurity as a risk factor for agenesis. 牙齿异常和病史：早产是发育不全的危险因素。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-20 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.010

Amanda Craveiro Carvalho Dib, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Francisco Wanderley Garcia de Paula E Silva, Paulo Nelson-Filho, Giuliana de Campos Chaves, Gabriela Reis Alves, Marília Pacífico Lucisano

{"title":"Dental anomalies and medical history: prematurity as a risk factor for agenesis.","authors":"Amanda Craveiro Carvalho Dib, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Francisco Wanderley Garcia de Paula E Silva, Paulo Nelson-Filho, Giuliana de Campos Chaves, Gabriela Reis Alves, Marília Pacífico Lucisano","doi":"10.1590/1807-3107bor-2026.vol40.010","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2026.vol40.010","url":null,"abstract":"The aims of this retrospective radiographic study were to assess the occurrence of dental anomalies in children and patients with disabilities and to investigate the association of these anomalies with pre-, peri-, and post-natal medical history. A total of 289 panoramic radiographs of children (0-14 years) and patients with disabilities (including all age groups) were used to identify developmental dental anomalies, and information was collected from medical records for statistical analysis. Data were expressed as relative frequency (percentage). The chi-square test, Fisher's exact test, relative risk calculation, and the Mann-Whitney test were used for statistical comparisons with a significance level of 5%. Occurrence of dental alterations was 50.34% in children and 37.50% in patients with disabilities. Agenesis was the most common alteration (24.14% in children and 30.55% in patients with disabilities). The study found a relative risk of 2.6 for agenesis in children with a history of prematurity (p = 0.02). The variable \"performing medical treatment\" was a risk factor for the presence of dental alterations in children. The age and the medical conditions of the patients with disabilities varied greatly, with neurological diseases being the most prevalent disability. However, the health history of mothers during pregnancy was not associated with dental alterations in patients with disabilities (p > 0.05). Developmental dental anomalies were frequently observed in both groups, with agenesis being the most common condition. Prematurity was identified as a predictive factor for agenesis.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e010"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower dental pulp oxygen saturation in children with molar incisor hypomineralization: a cross-sectional study. 磨牙切牙矿化儿童低牙髓氧饱和度：一项横断面研究。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-20 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.009

Jade de Souza Cavalcante, Carlos Estrela, Fabrício Kitazono de Carvalho, Francisco Wanderley Garcia de Paula-Silva, Manoel Damião de Sousa-Neto, Kelly Fernanda Molena, Alexandra Mussolino de Queiroz

{"title":"Lower dental pulp oxygen saturation in children with molar incisor hypomineralization: a cross-sectional study.","authors":"Jade de Souza Cavalcante, Carlos Estrela, Fabrício Kitazono de Carvalho, Francisco Wanderley Garcia de Paula-Silva, Manoel Damião de Sousa-Neto, Kelly Fernanda Molena, Alexandra Mussolino de Queiroz","doi":"10.1590/1807-3107bor-2026.vol40.009","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2026.vol40.009","url":null,"abstract":"This study evaluated the oxygen saturation of pulp tissue (SaO2) in first primary molars (FPM) with and without molar incisor hypomineralization (MIH) and explored the correlations between MIH severity and pulp SaO2 levels. The cross-sectional design involved 29 children (16 girls and 13 boys, aged 7-11 years), yielding 116 FPM. The FPM were categorized into groups based on the presence or absence of MIH: Group 1 (G1) included teeth without MIH (n = 48); Group 2 (G2), mild MIH cases (n = 30); and Group 3 (G3), severe MIH cases (n = 38). Pulse oximetry was used to assess SaO2, with measurements conducted twice for each tooth, each lasting 30 seconds. Significant variations in the SaO2 levels were observed relative to the severity of MIH. The median SaO2 in G1 was 94% (IQR 90-98%), while MIH cases showed lower levels: 79% (IQR 71.5-83.5%) for mild MIH (G2) and 68% (IQR 55-75%) for severe MIH (G3) (p < 0.001). The FPM affected by MIH (G2 and G3) demonstrated lower SaO2 levels than those in G1, with severe cases exhibiting even lower levels than mild cases. This study provides important insights into the relationship between MIH severity and pulp SaO2 and suggests significant implications for clinical management strategies.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e009"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of preoperative coagulation scoring system in patients with oral squamous cell carcinoma. 术前凝血评分系统对口腔鳞状细胞癌患者预后的价值。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-20 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.007

Xuming Wang, Xiaoli Ji

{"title":"Prognostic value of preoperative coagulation scoring system in patients with oral squamous cell carcinoma.","authors":"Xuming Wang, Xiaoli Ji","doi":"10.1590/1807-3107bor-2026.vol40.007","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2026.vol40.007","url":null,"abstract":"Abnormal coagulation function is closely associated with the prognosis of patients with malignant tumors. In this study, we aimed to explore the prognostic value of preoperative coagulation scoring system in patients with oral squamous cell carcinoma (OSCC). A total of 267 patients with OSCC who were treated at the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University between January 2016 and December 2019 were included. Survival prediction values for fibrinogen level and international normalized ratio (INR) were identified according to receiver operating characteristic (ROC) cut-off analysis. Patients were divided into three groups based on the F-INR score combined with fibrinogen and INR: score 2 group (both high fibrinogen and high INR), score 1 group (either elevated fibrinogen or INR), and score 0 group (neither abnormality). The association between F-INR score and clinicopathological parameters was evaluated. The clinical risk factors were evaluated using univariate and multivariate Cox regression analyses. Kaplan-Meier analysis was used to estimate the survival of patients with OSCC. The predictive value of preoperative F-INR in OSCC was better than that of fibrinogen and INR alone (area under the curve, (AUC): 0.766 vs. 0.704 vs. 0.611). Multivariate Cox regression analysis showed that F-INR may be an independent predictor of cancer-specific survival (CSS) in OSCC (F-INR 1, hazard ratio [HR] = 8.210, 95%CI: 1.156-58.282, p = 0.035; F-INR 2, HR = 2.475, 95%CI: 1.284-4.772, p = 0.007). Kaplan-Meier analysis indicated that patients with high fibrinogen levels or F-INR had a poor prognosis (p < 0.05). Preoperative F-INR may be an independent prognostic factor in patients with OSCC.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e007"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytocompatibility and bioactive potential of Pentaclethra macroloba extract and Ca(OH)2 as intracanal medication. 大叶五甲草提取物和Ca(OH)2作为内源性药物的细胞相容性和生物活性潜力。

IF 1.3 4区医学

Brazilian oral research Pub Date : 2026-03-20 eCollection Date: 2026-01-01 DOI: 10.1590/1807-3107bor-2026.vol40.008

Maria Luiza Gioster-Ramos, Patricia Milagros Maquera-Huacho, Natalia da Ponte Leguizamon, Denise Palomari Spolidorio, Roberto Messias, Milton Carlos Kuga, Luis Geraldo Vaz

{"title":"Cytocompatibility and bioactive potential of Pentaclethra macroloba extract and Ca(OH)2 as intracanal medication.","authors":"Maria Luiza Gioster-Ramos, Patricia Milagros Maquera-Huacho, Natalia da Ponte Leguizamon, Denise Palomari Spolidorio, Roberto Messias, Milton Carlos Kuga, Luis Geraldo Vaz","doi":"10.1590/1807-3107bor-2026.vol40.008","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2026.vol40.008","url":null,"abstract":"Alternative therapies using plant-derived extracts are currently being studied due to their beneficial properties. This study investigated the Amazonian extract of Pentaclethra macroloba, pure and in combination with calcium hydroxide, regarding its biological properties in endodontics. Osteoblast Saos-2 and Fibroblast L929 cell lines were used for evaluation of cell viability/metabolism by MTT (48h), cell proliferation with Alamar blue (1, 3, 5 and 7 days), mineralization with Alizarin Red (7 days) and alkaline phosphatase activity (7 days). In Saos-2, lower concentrations of the medications were less cytotoxic in the MTT assay. There was cell proliferation on days 3 and 5. Mineralization nodules were observed in the 3 groups. In L929 cells, the lowest concentrations were not cytotoxic in the MTT assay, and there was cell proliferation on days 3, 5, and 7. Pentaclethra macroloba extract was not cytotoxic, it induced cell proliferation, and was able to form mineralization nodules, essential characteristics for endodontic medications.","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e008"},"PeriodicalIF":1.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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