Kyoko Asazawa, Mina Jitsuzaki, Akiko Mori, Tomohiko Ichikawa
{"title":"Decisional conflicts of male patients undergoing Assisted Reproductive Technology: a qualitative study.","authors":"Kyoko Asazawa, Mina Jitsuzaki, Akiko Mori, Tomohiko Ichikawa","doi":"10.1186/s13104-025-07493-9","DOIUrl":"10.1186/s13104-025-07493-9","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the decisional conflicts of men undergoing Assisted Reproductive Technology (ART). We used a qualitative descriptive research design. The participants were 10 men who had received ART. Data were collected from June to August 2023 by conducting semistructured interviews using a guide. The inclusion criteria were male patients who have experienced various infertility treatments and are currently receiving ART and within 5 years of their infertility treatment.</p><p><strong>Results: </strong>The participants were 10 men undergoing outpatient infertility treatment at two infertility treatment facilities in Tokyo. Four categories of decisional conflicts were extracted: \"Uncertainty whether ART is the best treatment\", \"Lack of clarity as to what is the most important considering the risks and benefits of ART\", \"No information on the benefits and risks of ART to decide whether to continue or terminate ART\", and \"Insufficient information on other male infertile patients' therapeutic decisions\". Men undergoing ART experienced different decisional conflicts as specified above. Identification of the main categories and subcategories of these decisional conflicts may be useful for the future development of decision-making support for men undergoing ART.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"407"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daynia E Ballot, Rossella Bandini, Tanusha D Ramdin
{"title":"A retrospective study to determine whether there is an association between maternal HIV infection and neonatal hypoxic-ischaemic encephalopathy in a tertiary hospital in Johannesburg, South Africa.","authors":"Daynia E Ballot, Rossella Bandini, Tanusha D Ramdin","doi":"10.1186/s13104-025-07488-6","DOIUrl":"10.1186/s13104-025-07488-6","url":null,"abstract":"<p><p>Hypoxic ischaemic encephalopathy (HIE) due to perinatal asphyxia is prevalent in South Africa. Almost one-third of mothers in South Africa are HIV-positive. This secondary analysis of an existing database sought to determine the association between maternal HIV status and neonatal HIE. There were 5846 neonates weighing more than 1800 g, and 824 (14.1%) had HIE. According to univariate analysis, more neonates without HIE than neonates with HIE were born to HIV-positive mothers (26.2% vs 22.6%, p 0.026). However, according to the binary logistic regression, the variables significantly associated with neonatal HIE were maternal age, vaginal delivery, maternal diabetes, and place of birth. There was no association between maternal HIV and neonatal HIE. This negative finding may be due to the high rate of prevention of mother-to-child transmission in the present study 95.2% of mothers received antiretroviral therapy during pregnancy. This study was a secondary analysis of an existing database from a single centre, so the results may not be generalizable. Factors such as maternal CD4 count, viral load, type and duration of antiretroviral therapy were not available for analysis.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"398"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hani Mohamed Mohamud, Charles Idehen, Bot Yakubu Sunday, Yibala Ibor Oboma, Mirna Batista, Idania Hidalgo, Maria Ali Mudei, Mustfe Ahmed Awil, Yahya Ahmed Abdi, Shafie Ali Omar, Eliah Kwizera
{"title":"Effect of codeine administration on histopathology of brain and liver, in adult albino rats.","authors":"Hani Mohamed Mohamud, Charles Idehen, Bot Yakubu Sunday, Yibala Ibor Oboma, Mirna Batista, Idania Hidalgo, Maria Ali Mudei, Mustfe Ahmed Awil, Yahya Ahmed Abdi, Shafie Ali Omar, Eliah Kwizera","doi":"10.1186/s13104-025-07461-3","DOIUrl":"10.1186/s13104-025-07461-3","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the histopathological effects of codeine on brain and liver tissues in 24 adult albino rats. The rats were divided into four groups: a control group and three experimental groups that received oral codeine at 5 mg/kg, 10 mg/kg, and 20 mg/kg for 14 and 28 days. At each time point, animals were sacrificed, and histological examination of the brain (hippocampus and cerebral cortex) and liver was performed using hematoxylin and eosin staining.</p><p><strong>Results: </strong>A dose-dependent neuronal degeneration in the hippocampus and cerebral cortex, with higher doses causing severe neurodegeneration, was demonstrated. Liver histology revealed inflammatory infiltration, fatty degeneration, and hepatocyte necrosis in codeine-treated groups. Despite comparable histological injury at both durations, a statistically significant increase in body weight was observed at 28 days. Codeine administration leads to dose- and duration-dependent neurotoxic, and hepatotoxic changes, likely mediated by mechanisms involving neuroinflammation, glutamate excitotoxicity, and mitochondrial dysfunction.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"393"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Azizkhani, Mohammad Ali Yadgary, Soheila Rabie Siahkali, Kamyar Mansori
{"title":"Clinical and hemodynamic outcomes of hemoperfusion therapy for COVID-19 patients: a historical cohort study.","authors":"Leila Azizkhani, Mohammad Ali Yadgary, Soheila Rabie Siahkali, Kamyar Mansori","doi":"10.1186/s13104-025-07483-x","DOIUrl":"10.1186/s13104-025-07483-x","url":null,"abstract":"<p><strong>Background: </strong>Inflammation exacerbates COVID-19. Hemoperfusion removes toxins and inflammatory elements from the circulation; however, its effect on COVID-19 is uncertain. The clinical and hemodynamic outcomes of COVID-19 patients after hemoperfusion are the focus of this study.</p><p><strong>Methods: </strong>This historical cohort study was conducted on a group of 320 individuals diagnosed with COVID-19 between March 2020 and June 2022 in Zanjan, Iran. The required variables were extracted from the patient's hospital records using a pre-established checklist. The chi-square test, Fisher's exact test, the Mann-Whitney test, and the repeated measure ANOVA test were employed. The data analysis programme employed was SPSS version 26.</p><p><strong>Results: </strong>Participants in the study had a mean age of 64.82 ± 12.46 years. The association between exposure to hemoperfusion and clinical status, degree of lung involvement, and intubation was found to be statistically significant (P-value < 0.05). There were statistically significant differences between the two groups in the mean GCS, platelet count, WBC, hemoglobin level, breaths per minute, systolic blood pressure, the number of neutrophils and lymphocytes and SPO2 at different time points (P-value group*time < 0.05).</p><p><strong>Conclusion: </strong>Patients with severe COVID-19 who undergo hemoperfusion treatment appear to experience improvements in both their clinical and hemodynamic status. We need to conduct additional research in order to verify this.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"397"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Millawage Supun Dilara Wijesinghe, Nissanka Achchi Kankanamalage Ayoma Iroshanee Nissanka, Gayani Sandeepika Dissanayake, Upeksha Gayani Karawita, Balangoda Muhamdiramlage Indika Gunawardana, Weerasinghe Mudiyanselage Prasad Chathuranga Weerasinghe, Rathnayaka Mudiyanselage Madushani Shiyamala Rathnayaka, Kanchana Lanka Kumari Mahagamage, Rajapaksha Pathirage Manjula Sandamali, Rajan Thavaseelan, Ranjith Batuwanthudawe, A M A A P Alagiyawanna
{"title":"Community-based interventions to improve child nutrition knowledge, attitudes and practices: a pilot study in three nutritionally vulnerable Sri Lankan districts.","authors":"Millawage Supun Dilara Wijesinghe, Nissanka Achchi Kankanamalage Ayoma Iroshanee Nissanka, Gayani Sandeepika Dissanayake, Upeksha Gayani Karawita, Balangoda Muhamdiramlage Indika Gunawardana, Weerasinghe Mudiyanselage Prasad Chathuranga Weerasinghe, Rathnayaka Mudiyanselage Madushani Shiyamala Rathnayaka, Kanchana Lanka Kumari Mahagamage, Rajapaksha Pathirage Manjula Sandamali, Rajan Thavaseelan, Ranjith Batuwanthudawe, A M A A P Alagiyawanna","doi":"10.1186/s13104-025-07489-5","DOIUrl":"10.1186/s13104-025-07489-5","url":null,"abstract":"<p><strong>Objective: </strong>Child malnutrition remains a critical public health challenge in Sri Lanka and is exacerbated by socioeconomic disparities and gaps in community-based educational interventions. This mixed-methods study evaluated the effectiveness of a structured educational program delivered through mothers' support groups on maternal knowledge, attitudes, and practices related to child nutrition and well-being. This study was conducted across three districts (Nuwara Eliya, Trincomalee, and Puttalam), and the quasi-experimental design included pre- and postintervention surveys (n = 208) and focus group discussions with the mothers' support group members. A three-day interactive intervention covered nutrition-related topics, with knowledge, attitudes, and practices assessed via validated questionnaires and thematic analysis of qualitative data.</p><p><strong>Results: </strong>The quantitative results revealed slight non-statistically significant improvements in knowledge (10.77 ± 2.18-11.04 ± 2.38, p = 0.064), attitudes (29.12 ± 4.06-29.70 ± 3.85, p = 0.095), and practices (19.59 ± 3.48-20.46 ± 3.09, p = 0.051). The qualitative findings were more promising, revealing enhanced awareness of balanced diets, strengthened peer networks, and improved childcare practices. Key barriers include financial constraints, logistical challenges, and initial resistance, which can be mitigated through community engagement and multisectoral collaboration. This study demonstrates the potential of mothers' support group-led interventions to foster incremental behavioral changes and social cohesion, despite its limited, statistically significant findings. Scaling such programs requires addressing structural barriers, integrating sustained reinforcement, and leveraging partnerships with local stakeholders. These findings advocate for future research on sustainable, equity-focused nutrition interventions on a much larger scale.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"400"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The NAC transcription factor ATAF2 enhances Arabidopsis biomass and chlorophyll a accumulations at the early growth stage.","authors":"Hao Peng, Ying Zhai, Michael M Neff","doi":"10.1186/s13104-025-07421-x","DOIUrl":"10.1186/s13104-025-07421-x","url":null,"abstract":"<p><strong>Objective: </strong>The Arabidopsis thaliana NAC-family transcription factor ATAF2 plays extensive regulatory roles in plant disease resistance, abiotic stress tolerance, leaf senescence, hormone metabolism, and seedling photomorphogenesis. Using Arabidopsis seedlings as the investigation platform, we previously demonstrated that ATAF2 overexpression can increase the endogenous levels of the growth-promoting hormone brassinosteroids (BRs) and suppress the expression of the chlorophyll b (Chl-b) reductase NYC1, which catalyzes the initial step of the degradation of light-harvesting chlorophyll a/b-protein complex of photosystem II (LHCII). ATAF2 also promotes the expression of NIT2, which is involved in the biosynthesis of the auxin indole-3-acetic acid (IAA). Here, we further examined the effects of elevated BR/IAA levels and reduced NYC1 expression on biomass and Chl-a/b accumulations, respectively.</p><p><strong>Results: </strong>Twelve-day-old plants were harvested for biomass and Chl-a/b measurements. While no significant difference of biomass or Chl-a/b accumulations was observed between the wild-type Col-0 and the loss-of-function ataf2-1/2 plants, all three ATAF2 overexpression lines (ATAF2ox-1/2/3) exhibited much higher biomass and Chl-a accumulations as compared to Col-0 and ataf2-1/2, which can at least be partially interpreted as the consequences of higher endogenous BR/IAA levels and reduced NYC1 expression, respectively. The results demonstrate the positive regulatory role of ATAF2 in biomass and Chl-a accumulations. Notably, ATAF2 overexpression does not increase Arabidopsis biomass accumulation at later growth stages, indicating its functional nature of developmental timing acceleration.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"388"},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manfredo A Turcios-Casco, Alexandre Schiavetti, Pablo Teta
{"title":"The records from citizen science of an \"endemic\" agouti are not thoroughly evaluated nor examined.","authors":"Manfredo A Turcios-Casco, Alexandre Schiavetti, Pablo Teta","doi":"10.1186/s13104-025-07404-y","DOIUrl":"10.1186/s13104-025-07404-y","url":null,"abstract":"<p><strong>Objective: </strong>Citizen science supports conservation by contributing species occurrence data and promoting environmental education. However, the accuracy of these data remains a concern, particularly for endemic and poorly studied species. This study evaluates the spatial accuracy of citizen science records for the Roatán agouti (Dasyprocta ruatanica), an insular mammal endemic to the Bay Islands of Honduras. We specifically analysed geographic records sourced from the Global Biodiversity Information Facility (GBIF), mainly contributed through iNaturalist, to assess georeferencing quality and discuss potential misidentifications with the more widespread D. punctata.</p><p><strong>Results: </strong>Of 181 georeferenced records analysed, 80.11% were incorrectly placed-many located in the Atlantic Ocean rather than on Roatán-with a mean distance was 8.15 km (SD = 20.9 km), although the distribution was highly skewed due to a few extreme misplaced records. Furthermore, potential confusion between D. ruatanica and D. punctata was noted, likely due to morphological similarities and photographic limitations. These findings highlight the importance of careful precise geolocation and species identification when using citizen science data for conservation purposes, especially for insular endemics. Improved validation protocols and expert oversight are necessary to enhance the reliability of such records in biodiversity monitoring.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"389"},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Indicator bacteria taxa reveal breeding site origins of Aedes aegypti mosquitoes.","authors":"Katherine D Mosquera, Olle Terenius","doi":"10.1186/s13104-025-07482-y","DOIUrl":"10.1186/s13104-025-07482-y","url":null,"abstract":"","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"387"},"PeriodicalIF":1.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Predicting the effect of ethical climate and spiritual well-being of nurses on respecting the patients' privacy in intensive care units: an analytical study.","authors":"Roya Dokoohaki, Elham Afshari, Masoume Rambod, Mahdi Salmanpour","doi":"10.1186/s13104-025-07416-8","DOIUrl":"10.1186/s13104-025-07416-8","url":null,"abstract":"","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"386"},"PeriodicalIF":1.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}