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Predicting the effect of ethical climate and spiritual well-being of nurses on respecting the patients' privacy in intensive care units: an analytical study.
IF 1.6
BMC Research Notes Pub Date : 2025-03-13 DOI: 10.1186/s13104-025-07174-7
Roya Dokoohaki, Elham Afshari, Masoume Rambod, Mahdi Salmanpour
{"title":"Predicting the effect of ethical climate and spiritual well-being of nurses on respecting the patients' privacy in intensive care units: an analytical study.","authors":"Roya Dokoohaki, Elham Afshari, Masoume Rambod, Mahdi Salmanpour","doi":"10.1186/s13104-025-07174-7","DOIUrl":"10.1186/s13104-025-07174-7","url":null,"abstract":"<p><strong>Background: </strong>Ethical climate, observance of patients' privacy and nurses' spiritual well-being are of great importance in intensive care units (ICU). In addition, it is essential to identify spiritual and ethical predictors of patients' privacy. Thus, this study aimed to determine the predictive effects of ethical climate and nurses' spiritual well-being on patients' privacy in ICU.</p><p><strong>Methods: </strong>In this analytical cross-sectional study, 250 out of 500 ICU nurses were recruited using proportionate allocation stratified sampling. Data were collected using a demographic characteristics form, Patient Privacy Scale, Hospital Ethical Climate Survey, and Spiritual Well-Being Scale. The data were analyzed using Pearson correlation coefficient and hierarchical linear regression analysis.</p><p><strong>Results: </strong>The results showed that patients' privacy was associated with the hospital's ethical climate and nurses' spiritual well-being (P < 0.001). The hierarchical linear regression analysis indicated that, in step 1, patients (β = 0.22, P = 0.03) and managers' (β = 0.41, P < 0.001) subscales of ethical climate had a significant proportion of the variance of patients' privacy. In step 2, patients (β = 0.25, P = 0.01), managers' (β = 0.34, P < 0.001) subscales of ethical climate, and nurses' spiritual well-being (β = 0.17, P = 0.01) had a significant proportion of the variance of patients' privacy. According to step 2, these variables explained 40% of the changes in patients' privacy.</p><p><strong>Conclusion: </strong>The results of the present study showed that the ethical climate and nurses' spiritual well-being were the predictors of patients' privacy. Given that 40% of the variance of the patients' privacy was recognized by these variables, it is suggested that further research should be conducted to determine other predictors.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"111"},"PeriodicalIF":1.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PrOsteoporosis: predicting osteoporosis risk using NHANES data and machine learning approach.
IF 1.6
BMC Research Notes Pub Date : 2025-03-11 DOI: 10.1186/s13104-025-07089-3
Zebing Si, Di Zhang, Huajun Wang, Xiaofei Zheng
{"title":"PrOsteoporosis: predicting osteoporosis risk using NHANES data and machine learning approach.","authors":"Zebing Si, Di Zhang, Huajun Wang, Xiaofei Zheng","doi":"10.1186/s13104-025-07089-3","DOIUrl":"10.1186/s13104-025-07089-3","url":null,"abstract":"<p><strong>Objectives: </strong>Osteoporosis, prevalent among the elderly population, is primarily diagnosed through bone mineral density (BMD) testing, which has limitations in early detection. This study aims to develop and validate a machine learning approach for osteoporosis identification by integrating demographic data, laboratory and questionnaire data, offering a more practical and effective screening alternative.</p><p><strong>Methods: </strong>In this study, data from the National Health and Nutrition Examination Survey were analyzed to explore factors linked to osteoporosis. After cleaning, 8766 participants with 223 variables were studied. Minimum Redundancy Maximum Relevance and SelectKBest were employed to select the import features. Four Machine learning algorithms (RF, NN, LightGBM and XGBoost.) were applied to examine osteoporosis, with performance comparisons made. Data balancing was done using SMOTE, and metrics like F1 score, and AUC were evaluated for each algorithm.</p><p><strong>Results: </strong>The LightGBM model outperformed others with an F1 score of 0.914, an MCC of 0.831, and an AUC of 0.970 on the training set. On the test set, it achieved an F1 score of 0.912, an MCC of 0.826, and an AUC of 0.972. Top predictors for osteoporosis were height, age, and sex.</p><p><strong>Conclusions: </strong>This study demonstrates the potential of machine learning models in assessing an individual's risk of developing osteoporosis, a condition that significantly impacts quality of life and imposes substantial healthcare costs. The superior performance of the LightGBM model suggests a promising tool for early detection and personalized prevention strategies. Importantly, identifying height, age, and sex as top predictors offers critical insights into the demographic and physiological factors that clinicians should consider when evaluating patients' risk profiles.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"108"},"PeriodicalIF":1.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference intervals for CD4 and hemoglobin among apparently healthy pregnant women in Addis Ababa, Ethiopia.
IF 1.6
BMC Research Notes Pub Date : 2025-03-11 DOI: 10.1186/s13104-025-07171-w
Dinkenesh Chalchisa, Yohannes Belay, Melkitu Kassaw, Endalkachew Befekadu, Letebrhan G/Egzeabher, Gebremedhin Gebremicael, Boki Lengiso, Dawit Chala, Zewdineh Sahlemariam, Estifanos Kebede, Ebba Abate, Aster Tsegaye
{"title":"Reference intervals for CD4 and hemoglobin among apparently healthy pregnant women in Addis Ababa, Ethiopia.","authors":"Dinkenesh Chalchisa, Yohannes Belay, Melkitu Kassaw, Endalkachew Befekadu, Letebrhan G/Egzeabher, Gebremedhin Gebremicael, Boki Lengiso, Dawit Chala, Zewdineh Sahlemariam, Estifanos Kebede, Ebba Abate, Aster Tsegaye","doi":"10.1186/s13104-025-07171-w","DOIUrl":"10.1186/s13104-025-07171-w","url":null,"abstract":"<p><strong>Background: </strong>Most African countries, including Ethiopia, have not developed local well-defined reference intervals (RIs) for immuno-hematological testes in terms of pregnant women. As a result, we were using reference intervals derived from non-Africans. This is not appropriate because CD4 + T cell counts (CD4 count) are affected by several factors including ethnic and environmental factors. Therefore, this study aimed to develop reference interval for CD4 count for apparently healthy pregnant women in Addis Ababa, Ethiopia.</p><p><strong>Results: </strong>After excluding six pregnant women who did not pass the screening tests, 156 apparently healthy pregnant women who were 18-49 years old were included in the final analysis. The medians of CD4 absolute counts and CD4% with inter-quartile ranges [IQR] were 757.5 [611.3-925.5] cells/µL and 43.6% [39.9-47.3] respectively while the median and IQR hemoglobin values were 14.3 g/dL [13.4-15.1]. The respective reference intervals for absolute CD4 cell count and % CD4 were 416.9-1218.4 cells/µL and 32.1-57.3%, respectively. Significant changes were observed in hemoglobin level between trimesters (P < 0.05).</p><p><strong>Conclusion: </strong>The results of this study showed a decrease in both percentage and absolute CD4 + T cell counts when compared to those of non-African and African countries. Establishing local reference values for diverse groups is therefore crucial.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"106"},"PeriodicalIF":1.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of leadership and professional behavior of educational managers in the complex and post-crisis era: perspectives of educators.
IF 1.6
BMC Research Notes Pub Date : 2025-03-11 DOI: 10.1186/s13104-025-07166-7
Sara Jambarsang, Amir Houshang Mehrparvar, Fatemeh Keshmiri
{"title":"Assessment of leadership and professional behavior of educational managers in the complex and post-crisis era: perspectives of educators.","authors":"Sara Jambarsang, Amir Houshang Mehrparvar, Fatemeh Keshmiri","doi":"10.1186/s13104-025-07166-7","DOIUrl":"10.1186/s13104-025-07166-7","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate educational managers from the viewpoints of stakeholders (educators and faculty officials) during two years of the COVID-19 pandemic and two years of the post-COVID era. This was a longitudinal study conducted from 2018 to 2023 in two phases: the first phase consisted of compiling and psychometric assessment of the tools for evaluation of educational managers in the two domains of leadership and professional behavior, and the second phase included evaluation of leadership behavior and professional behavior of university educational managers during four years. Descriptive indices were used to summarize the data. Exploratory factor analysis was used to extract the priority components in the two domains of professional behavior and leadership behavior of educational managers.</p><p><strong>Results: </strong>The validity of the tools was confirmed in the first step. Adherence to the principles of professionalism such as honesty and responsibility, and the use of management principles including constructive communication, monitoring, and evaluation during the crisis and post-crisis were highlighted by the educational managers. Implementing evaluation and providing feedback in complex and critical times in educational systems facilitates the achievement of the goals of the system and responding to the needs of the system.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"107"},"PeriodicalIF":1.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.
IF 1.6
BMC Research Notes Pub Date : 2025-03-11 DOI: 10.1186/s13104-025-07165-8
Negin Kamali, Amin Talebi Bezmin Abadi, Farid Rahimi, Mojgan Forootan
{"title":"Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.","authors":"Negin Kamali, Amin Talebi Bezmin Abadi, Farid Rahimi, Mojgan Forootan","doi":"10.1186/s13104-025-07165-8","DOIUrl":"10.1186/s13104-025-07165-8","url":null,"abstract":"<p><strong>Objective: </strong>Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.</p><p><strong>Results: </strong>Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included. One hundred and eighty (60%) patients were negative and 120 (40%) positive for H. pylori. Associations between the presence of H. pylori and age, gender, or other demographics were statistically insignificant (p > 0.05). The prevalence of F. nucleatum infection was determined for the two patient categories: 215 patients (72%) were positive for F. nucleatum; of these cases, 95 showed evidence of, and 120 lacked, concomitant H. pylori infection. Gastric biopsies obtained from patients with gastric cancer but negative for H. pylori revealed a significant prevalence of F. nucleatum infection.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"109"},"PeriodicalIF":1.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic resistance and molecular characterization of clinical Shigella spp. isolated from hospitals located in Tehran and Qazvin cities, Iran.
IF 1.6
BMC Research Notes Pub Date : 2025-03-11 DOI: 10.1186/s13104-025-07113-6
Termeh Raoufian, Babak Pakbin, Akram Sadat Tabatabaee Bafroee
{"title":"Antibiotic resistance and molecular characterization of clinical Shigella spp. isolated from hospitals located in Tehran and Qazvin cities, Iran.","authors":"Termeh Raoufian, Babak Pakbin, Akram Sadat Tabatabaee Bafroee","doi":"10.1186/s13104-025-07113-6","DOIUrl":"10.1186/s13104-025-07113-6","url":null,"abstract":"<p><strong>Objective: </strong>This research aims to investigate the epidemiology and genetic changes of Shigella species in the cities of Qazvin and Tehran from 2003 to 2023, with a focus on assessing antibiotic resistance among the isolates. This study is based on the analysis of 80 Shigella isolates, which were obtained from patients' feces.</p><p><strong>Results: </strong>Using pulsed-field gel electrophoresis (PFGE) as the primary typing method, the isolates were classified into 13 distinct clusters, revealing a dominant pattern that has persisted for over twenty years. This persistence may be attributed to factors such as poor hygiene, personal contact, immigration, and antibiotic resistance. Genetic analysis indicated clonal expansion among the isolates over the two-decade period. Notably, the highest resistance was observed against amoxicillin, with several isolates exhibiting multidrug resistance.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"110"},"PeriodicalIF":1.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare research and education: actively constructed research knowledge-a model for online systematic reviews and meta-analyses courses. 医疗保健研究与教育:积极构建研究知识--在线系统综述和荟萃分析课程的模式。
IF 1.6
BMC Research Notes Pub Date : 2025-03-10 DOI: 10.1186/s13104-025-07111-8
Walid El Ansari, Kareem El-Ansari, Mohamed Hany
{"title":"Healthcare research and education: actively constructed research knowledge-a model for online systematic reviews and meta-analyses courses.","authors":"Walid El Ansari, Kareem El-Ansari, Mohamed Hany","doi":"10.1186/s13104-025-07111-8","DOIUrl":"10.1186/s13104-025-07111-8","url":null,"abstract":"<p><p>Employing a mixed-methods approach, this study: (a) scoped the literature for desirable characteristics of online learning environments; (b) analyzed and compared the available online systematic review and meta-analysis (SR/MA) courses; and (c) proposed an outline for a model online systematic review SR/MA course that is aligned with PRISMA principles, and (d) charted learning outcomes, module contents, interactive elements, feedback and module assessment, and course evaluation of the proposed course. The findings highlight the many distinctive aspects and design of the proposed model course, including its comprehensiveness, alignment with PRISMA principles, self-pace and self-direction, with high interactivity levels, augmented by the expert trainer guidance ('human' factor), and individualized feedback, and its conclusion with the incorporation of the learners in virtual research teams undertaking real SR/MA. The proposed model course integrates principles of problem-based learning, where in addition to the provided resources (interactive assignments and video tutorials), trainees will be actively conducting their own real SR/MA as part of the course, while receiving expert feedback to enhance learning outcomes. Assignments' scores will be used to evaluate the learners' proficiency levels, and to pinpoint strengths and areas requiring enhancement. Overall, the proposed model course stands out as an innovative initiative in online SR/MA training, offering a valuable and comprehensive online learner-centered, expert-guided, 'hands-on' educational approach to SR/MA training. This sets a benchmark for future online courses in research synthesis methodology within health, medical, surgical and related fields.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"103"},"PeriodicalIF":1.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time and cost involved in measuring access to medicines: the case of Albania.
IF 1.6
BMC Research Notes Pub Date : 2025-03-10 DOI: 10.1186/s13104-025-07168-5
E Petro, I R Joosse, A C M Siebers, T Martopullo, R P M Hart, A K Mantel-Teeuwisse, H A van den Ham, F Suleman
{"title":"Time and cost involved in measuring access to medicines: the case of Albania.","authors":"E Petro, I R Joosse, A C M Siebers, T Martopullo, R P M Hart, A K Mantel-Teeuwisse, H A van den Ham, F Suleman","doi":"10.1186/s13104-025-07168-5","DOIUrl":"10.1186/s13104-025-07168-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the resources involved in collecting data for both the WHO/Health Action International (HAI) methodology and the Sustainable Development Goal 3.b.3 indicator to determine the availability and affordability of medicines. Medicines from the WHO Global Core List (GCL) and a basket of pediatric medicines were chosen to reflect a comprehensive range of medicines. The objective was to analyze the time, financial, and human resource investments required to conduct such research in an upper-middle-income country like Albania.</p><p><strong>Results: </strong>Data collection, including travel required approximately 3.5 h per survey area, with a total of 36 h estimated across six areas, not including data analysis. Each survey area was visited by four data collectors. Although collecting this type of data was initially perceived as laborious, our findings revealed that this was primarily due to the pre-survey preparation rather than the data collection process itself. Transportation costs were calculated by including car rental and fuel costs and totaled 120 euro. This exploratory assessment offers valuable insights into the practical challenges of evaluating access to medicines, which can help improve data collection strategies and inform evidence-based policy development to enhance medicine availability and affordability in the future.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"104"},"PeriodicalIF":1.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of an educational discharge program based on Orem's self-care model on lifestyle, hope, and treatment adherence in coronary angioplasty patients: a randomized controlled clinical trial.
IF 1.6
BMC Research Notes Pub Date : 2025-03-10 DOI: 10.1186/s13104-025-07164-9
Zahra Mohebi, Mostafa Bijani, Abdulhakim Alkamel, Azizallah Dehghan, Shahnaz Karimi
{"title":"The impact of an educational discharge program based on Orem's self-care model on lifestyle, hope, and treatment adherence in coronary angioplasty patients: a randomized controlled clinical trial.","authors":"Zahra Mohebi, Mostafa Bijani, Abdulhakim Alkamel, Azizallah Dehghan, Shahnaz Karimi","doi":"10.1186/s13104-025-07164-9","DOIUrl":"10.1186/s13104-025-07164-9","url":null,"abstract":"<p><strong>Objective: </strong>Patient education at the time of discharge using models which aim to improve self-care behaviors can significantly contribute to patients' adoption of a healthy lifestyle and treatment adherence. This is a randomized controlled clinical trial with no blinding in which we tested two groups of intervention control. 90 patients having undergone coronary angioplasty were allocated to an intervention (N = 45) and a control group randomly (N = 45). Data were collected from January to October 2022. The data collection instruments comprised angioplasty patients' treatment adherence questionnaire, Walker's health-promoting lifestyle profile questionnaire, and Snyder's Hope Scale. Data analysis was performed using SPSS version 23. To analyze the data, we used descriptive statistics. Accordingly, inferential statistics applied included chi-square, independent-samples t-test, and repeated measures (ANOVA). Significance level was considered as p < 0.05.</p><p><strong>Results: </strong>The mean scores of lifestyle, hope, and treatment adherence in the intervention group were significantly higher than those of the control group as measured immediately and three months after the intervention (p < 0.05). The study results revealed that using discharge program based on Orem's self-care model positively impacted the lifestyle, hope, and treatment adherence of patients having experienced coronary angioplasty.</p><p><strong>Iranian registry of clinical trials: </strong>IRCT registration number: IRCT20190917044802N5.</p><p><strong>Registration date: </strong>17/7/2022.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"105"},"PeriodicalIF":1.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal irisin is inversely related to the term placental telomere length.
IF 1.6
BMC Research Notes Pub Date : 2025-03-08 DOI: 10.1186/s13104-025-07118-1
Farzaneh Abasnezhad Kasrineh, Ozra Sadat Esmaeili, Tayyebeh Tavakoli, Parvin Khalili, Zohreh Rajabi, Hajar Vatankhah, Mohammad Reza Hajizadeh, Mehdi Mahmoodi, Hamid Hakimi, Zahra Jalali
{"title":"Prenatal irisin is inversely related to the term placental telomere length.","authors":"Farzaneh Abasnezhad Kasrineh, Ozra Sadat Esmaeili, Tayyebeh Tavakoli, Parvin Khalili, Zohreh Rajabi, Hajar Vatankhah, Mohammad Reza Hajizadeh, Mehdi Mahmoodi, Hamid Hakimi, Zahra Jalali","doi":"10.1186/s13104-025-07118-1","DOIUrl":"10.1186/s13104-025-07118-1","url":null,"abstract":"<p><p>Irisin is a myokine mainly produced by skeletal muscle that impacts the body's systemic metabolism. It is connected to aging, telomere length, and oxidative stress markers in human adults and in vitro. The serum irisin concentration increases during pregnancy and has been linked to some birth outcomes like macrosomia. On the other hand, its inverse relation with the chance of pregnancy disorders like preeclampsia and gestational diabetes suggests a protective role for this myokine in pregnancy. It is suggested that irisin may exert its impact on pregnancy by affecting the placenta, which has not been studied yet. Here, we questioned whether prenatal serum irisin is related to placental markers, including telomere length and antioxidant activity. Research has shown that the status of these markers at birth can predict the predisposition to some chronic diseases later in life. We included 80 pregnant mothers (17-41 years old) and newborn dyads randomly selected from the enrolled participants of the Rafsanjan Birth Cohort Study (one of the five district areas of the PERSIAN birth cohort studies), who delivered at the Nik-Nafs Maternity Hospital in Rafsanjan in 2022. Irisin levels were measured in the mother's blood serum in pregnancy using ELISA. The relative telomere length and the GPX and SOD enzyme activities were measured in the term placenta using real-time PCR and colorimetric assays, respectively. We found an inverse relationship between the serum irisin levels during pregnancy and relative telomere length in the term placenta. Irisin level was not significantly associated with the activity of SOD and GPX enzymes. Therefore, our data does not support the protective role of prenatal irisin on the placental telomere shortening and oxidative stress. Future studies are warranted to assess more placental markers in relation to pregnancy irisin levels.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"102"},"PeriodicalIF":1.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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