BMC Research Notes最新文献

{"title":"HIV prevalence in pregnant women attending antenatal consultations in Senegal in 2021.","authors":"Abou Abdallah Malick Diouara, Sarbanding Sané, Sophie Deli Tene, Seynabou Coundoul, Fatou Thiam, Habibou Sarr, Halimatou Diop Ndiaye, Ousseynou Ndiaye, Seynabou Lo, Fodé Danfakha, Marie Edouard Faye Diéme, Babacar Biaye, Noel Magloire Manga, Cheikh Momar Nguer, Coumba Toure Kane, Martine Peeters, Ahidjo Ayouba","doi":"10.1186/s13104-025-07491-x","DOIUrl":"10.1186/s13104-025-07491-x","url":null,"abstract":"<p><p>HIV/AIDS infection is a significant public health issue, particularly among vulnerable populations like pregnant women. Despite progress in prevention, diagnosis, early management and treatment, there is still a need to strengthen efforts toward eliminating mother-to-child transmission (eMTCT). This study aimed to update the seroprevalence of HIV in pregnant women attending antenatal consultations in Senegal. Blood samples from 1,227 participants were collected from March to July 2021. The plasma samples were processed within 2 h after collection and were frozen at - 80 °C or stored at - 20 °C on site until processing. Serological tests were carried out using national diagnostic algorithms. Rapid diagnostic tests (RDTs) were used at all screening stages, starting with the DetermineTM HIV-1/2 Abott test. Positive samples were confirmed with the SD bioline HIV-1/2 3.0 test and Multisure^® MP diagnostics typing test, following the manufacturer's instructions. Statistical tests were conducted using JMP^® Pro Version 15.0.0 software. The HIV prevalence found was 1.05% [95% CI: 0.69-1.80], with variations by locality: Kédougou at 2.2% [95% CI: 1.20-4.25] and Ziguinchor at 1.5% [95% CI: 0.59-3.83]. No HIV cases were found in Dakar and Saint-Louis. Considering the national HIV prevalence and the risk of mother-to-child transmission, these results remain concerning for Senegal and stress the need to continued awareness-raising and targeted interventions in the South and South-East regions are necessary.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"399"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HIV disclosure and related predictors on CD4 cell count among adults under first-line ART regimen at Felege Hiwot comprehensive specialized referral hospital, North West Ethiopia.","authors":"Abdela Assefa Bekele, Awoke Seyoum Tegegne, Nurye Seid Muhie","doi":"10.1186/s13104-025-07477-9","DOIUrl":"10.1186/s13104-025-07477-9","url":null,"abstract":"<p><strong>Background: </strong>Disclosure of HIV status potentially leads patients aware of their infection and accelerates access to timely care. The main objective of the current study was to investigate the impact of disclosure and related predictors on CD4 cell count among HIV positive adults under first-line ART Regimen at Felege Hiwot Comprehensive specialized Hospital, North West Ethiopia.</p><p><strong>Methods: </strong>A hospital based retrospective study design was conducted to investigate the impact of disclosure and related predictors on CD4 cell count. Independent samples t-test was conducted to compare the magnitude of CD4 cell count between adults disclosed and those who did not. A negative Binomial regression model was conducted to investigate the predictors of CD4 cell count.</p><p><strong>Result: </strong>Out of 300 adult participants, about 76% of the patients disclosed their disease status to their family members. The correlation for CD4 cell count and disclosure of disease status was about 0.4607 which indicates that disclosure had a positive impact on the progress of CD4 cell count for HIV-adults under treatment. The current study indicates that among the predictor variables, age of patients (β= -0.0744, p-value = 0.0017), Visiting time (β = 0.005296, p-value = 0.0017), baseline CD4 cell count (β = 0.00526, p-value < 0.0001), disclosure of HIV disease (β = 0.5084, p-value < 0.0001), non-educated patients (β = -0.3720, p-value < 0.00009), employed patients (β = 0.2062, p-value < 0.0001), adherent patients (β = 0.1339, p-value < 0.0001), WHO stage I (β = 0.5712; p-value < 0.0001), TB infected HIV positive adult (β= -0.2035, p-value < 0.0008), HIV positive adults without opportunistic infection (β = 0.3001, p-value < 0.0001), Social support (β=- 0.1981, p-value < 0.0004) had significant effect for the variation of CD4 cell count.</p><p><strong>Conclusion: </strong>The result of this study concluded that, disclosure of HIV disease status had positive significant impact for CD4 cell count among the patients under treatment at first line regimen. Especial attention should be given for HIV positive adults with TB and other opportunistic infection and for aged HIV patients. In addition, health staff should conduct health related education for individuals regard to use of medication adherence and use of disclosing HIV status for treatment outcomes.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"403"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an antibiotic and a probiotic on phage communities in the swine gut microbiota.","authors":"Éléonore Lemieux, Xavier C Monger, Linda Saucier, Steve J Charette, Frédéric Guay, Éric Pouliot, Sylvain Fournaise, Antony T Vincent","doi":"10.1186/s13104-025-07484-w","DOIUrl":"10.1186/s13104-025-07484-w","url":null,"abstract":"<p><strong>Objective: </strong>The impact of dietary treatments on the phage community of porcine intestinal microbiota is not well understood. An antibiotic (tylvalosin), a probiotic (Pediococcus acidilactici), and a combination of these were given to six cannulated pigs in a double crossover design study. Samples of ileal digesta and feces were collected and whole genome shotgun sequencing was performed. The variations in phage and bacterial communities were compared for each treatment and sample type.</p><p><strong>Results: </strong>The bacteriophages present in the gut microbiome exhibited greater variations in both α- and β-diversity between sample types (digesta, feces) than between treatments. β-diversity and differential abundance showed that the effect of the combined antibiotic and probiotic treatment was the same as with the antibiotic alone. However, the effects of the probiotic and antibiotic treatments were statistically significantly different in the fecal samples. β-diversity was different in those two treatments, and differential abundance analysis identified multiple phages as markers for each treatment. No significant variations in relative abundance were found in phage lifestyle (i.e., virulent, temperate) between treatments.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"402"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violence against housemaids and associated factors in Jimma town, Southwest Ethiopia, 2023.","authors":"Hiwot Aynalem, Misra Abdulahi, Tujuba Diribsa","doi":"10.1186/s13104-025-07271-7","DOIUrl":"10.1186/s13104-025-07271-7","url":null,"abstract":"<p><strong>Background: </strong>Violence against women is a pervasive public health problem that remains hidden and largely underreported. Although all women are vulnerable to violence, the probability of experiencing violence against housemaids seems to be particularly high. However, evidence on the prevalence of violence against housemaids and associated factors is scarce.</p><p><strong>Objectives: </strong>To assess the prevalence and factors associated with violence against housemaids in Jimma town, southwestern Ethiopia, in 2023.</p><p><strong>Methods: </strong>A community-based cross-sectional study design of 422 housemaids living in Jimma town. Simple random sampling was used to select participants. To collect the data, a questionnaire administered during a pretested structured interview was used. Quantitative data were collected using an open data kit and then exported to SPSS version 26. Bivariate analysis was performed to select candidate variables with P values < 0.25. Then, multivariable logistic regression was used to determine factors associated with P values less than 0.05 with their respective AORs and 95% CIs. Finally, a report was presented.</p><p><strong>Results: </strong>The work lifetime prevalence of violence against housemaids was 61.7%. Violence against housemaids during their work lifetime was associated with having no formal education (AOR = 3.7; 95% CI: 1.22-11.33), having a duration of work greater than four years (AOR = 2.6; 95% CI:1.44-4.99), having two to four durations of work (AOR = 2.4; 95% CI:1.29-4.61), having a job by broker (AOR = 2.8; 95% CI:1.72-4.62), lacking a specific task (AOR = 1.8: 95% CI:1.07-2.90), no social support (AOR = 4.5; 95% CI:1.56-12.89), and having more than six families (AOR = 5.4; 95% CI,2.19-13.49).</p><p><strong>Conclusion and recommendation: </strong>The prevalence of violence against housemaids was relatively high. Over one-third (46.7%) of them experienced at least one incident of physical, psychological, or sexual violence. Educational status, duration of work, having a job with a broker, lack of specific tasks, social support, and family size were factors associated with violence against housemaids.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"390"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic near peer mentoring: evaluating its effects on satisfaction and learning among medical education graduate students.","authors":"Somaye Sohrabi, Masume Najarian, Masomeh Kalantarion","doi":"10.1186/s13104-025-07462-2","DOIUrl":"10.1186/s13104-025-07462-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the feasibility, satisfaction, and learning outcomes associated with an electronic near-peer mentoring (ENPM) program for master's students in medical education. The program leveraged existing digital infrastructure to provide academic and psychosocial support through structured interactions between senior mentors and junior mentees.</p><p><strong>Results: </strong>The program demonstrated high feasibility and was well-received. Satisfaction levels were notably high among both mentees (80%) and mentors (100%). Mentees reported significant academic (75%) and psychosocial (50%) benefits. However, perceived shared values (70% neutral) and structural support (40% agreed) were identified as areas for improvement. While mentors highly valued the supportive experience, a majority (57%) found it time-consuming. Academic performance, as measured by GPA, was high overall (18.14 ± 0.72), but no significant statistical correlation was found between satisfaction levels and GPA (ρ = 0.18, p = 0.31). The findings suggest ENPM is a promising model for scalable academic support in digital graduate education, with sustainability hinging on addressing time demands for mentors and enhancing structural support for mentees.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"391"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a patient-ventilator asynchrony (PVA) management protocol on treatment outcomes in ICU patients: a randomized controlled trial.","authors":"Mayam Roze Ahvazi, Mohammad Adineh, Mohsen Savaie, Saeed Ghanbari","doi":"10.1186/s13104-025-07467-x","DOIUrl":"10.1186/s13104-025-07467-x","url":null,"abstract":"<p><strong>Background: </strong>Mechanical ventilation is a critical life support for ICU patients. However, this intervention can be associated with complications such as patient-ventilator asynchrony (PVA) and subsequent adverse events. This study aimed to investigate the impact of implementing a PVA management protocol on clinical outcomes in ICU patients.</p><p><strong>Methods: </strong>In this single-blind randomized controlled trial conducted from January to August 2024, a total of 66 mechanically ventilated patients admitted to the ICU of a hospital affiliated with Ahvaz Jundishapur University of Medical Sciences (Ahvaz, Iran) were randomly allocated to either an intervention or control group using a permuted block randomization method. Patients in the intervention group were evaluated for patient-ventilator asynchrony (PVA) every two hours throughout their ICU stay, as long as they remained on mechanical ventilation. If PVA was detected, appropriate interventions were implemented in accordance with the protocol of PVA management. The control group received routine care without a specific PVA management protocol. Data were collected using a structured checklist and analyzed using SPSS version 22. This study registered in the Iranian Registry of Clinical Trials (IRCT20231001059572N1).</p><p><strong>Results: </strong>There was a significant difference between the intervention and control groups in terms of duration of mechanical ventilation (p < 0.001), length of ICU stay (p < 0.001), and successful weaning from the ventilator (p < 0.001). In all three dimensions, the intervention group showed better outcomes. However, there was no significant difference between the two groups in terms of ICU mortality (p = 0.202) and self-extubation (p = 0.787). Being in the intervention group was the strongest predictive factor for length of ICU stay (β = -8.268, p < 0.001) and duration of mechanical ventilation (β = -3.906, p = 0.003). No major harms or unintended adverse effects were reported related to the intervention.</p><p><strong>Conclusion: </strong>Implementation of a PVA management protocol was associated with improved clinical outcomes, including reduced duration of mechanical ventilation, shorter ICU stays, and higher rates of successful weaning. Given its simplicity, cost-effectiveness, and the favorable results observed, broader adoption of this protocol in ICU settings is recommended. Further studies are warranted to confirm these findings and examine their generalizability across different clinical contexts.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"396"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and effects of pulmonary embolism on hospital outcomes among COVID-19 patients.","authors":"Akash Nijhawan, Jiana Baker, Munir Adamo, Rafey Khan, Shebin George, Mukesh Roy, Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Sandeep Appunni, Peter McGranaghan, Javier Jimenez, Sandra Chaparro","doi":"10.1186/s13104-025-07295-z","DOIUrl":"10.1186/s13104-025-07295-z","url":null,"abstract":"","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"405"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of plasmid-mediated quinolone resistant genes among uropathogenic Escherichia coli isolates in Bushehr, south of Iran.","authors":"Matin Aref, Javad Fathi, Parisa Ghazanfari, Yalda Malekzadegan, Behdokht Jamali","doi":"10.1186/s13104-025-07463-1","DOIUrl":"10.1186/s13104-025-07463-1","url":null,"abstract":"<p><strong>Objectives: </strong>Uropathogenic Escherichia coli (UPEC) is important in urinary tract infection (UTI). Quinolones and fluoroquinolones are broad-spectrum antibiotics for the treatment of UTI, although some of UPEC are resistant to these antibiotics. This study aims to investigate phenotypic and genotypic characterization of plasmid-mediated quinolone resistance UPEC isolated from patients with UTI in Bushehr. In this study, 105 isolates of UPEC were identified by standard microbiological tests and the susceptibility pattern of quinolone and fluoroquinolone were determined by the disc diffusion method. PCR was used to check the presence of plasmid-mediated quinolone resistance genes.</p><p><strong>Results: </strong>Pattern of antibiotic susceptibility showed that more than 50% and 75% of isolates were resistant to fluoroquinolones and quinolones, respectively. The frequencies of qnrS and qnrB genes were 49.5% and 23.8%, respectively. Based on analysis, there was a significant relationship between the presence of the qnrB gene and resistance to ciprofloxacin, norfloxacin, ofloxacin and levofloxacin. There was a significant relationship between the presence of qnrS gene and resistance to the tested antibiotics. Our results showed a high level of resistance to fluoroquinolones. Therefore, it is necessary to treat and prevent UTI so that physicians can use alternative antibiotics to treatment of patients based on laboratory results.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"404"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human platelets support Semliki Forest virus replication.","authors":"Cameron J Stockwell, Matthew S Hindle","doi":"10.1186/s13104-025-07470-2","DOIUrl":"10.1186/s13104-025-07470-2","url":null,"abstract":"","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"406"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decisional conflicts of male patients undergoing Assisted Reproductive Technology: a qualitative study.","authors":"Kyoko Asazawa, Mina Jitsuzaki, Akiko Mori, Tomohiko Ichikawa","doi":"10.1186/s13104-025-07493-9","DOIUrl":"10.1186/s13104-025-07493-9","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the decisional conflicts of men undergoing Assisted Reproductive Technology (ART). We used a qualitative descriptive research design. The participants were 10 men who had received ART. Data were collected from June to August 2023 by conducting semistructured interviews using a guide. The inclusion criteria were male patients who have experienced various infertility treatments and are currently receiving ART and within 5 years of their infertility treatment.</p><p><strong>Results: </strong>The participants were 10 men undergoing outpatient infertility treatment at two infertility treatment facilities in Tokyo. Four categories of decisional conflicts were extracted: \"Uncertainty whether ART is the best treatment\", \"Lack of clarity as to what is the most important considering the risks and benefits of ART\", \"No information on the benefits and risks of ART to decide whether to continue or terminate ART\", and \"Insufficient information on other male infertile patients' therapeutic decisions\". Men undergoing ART experienced different decisional conflicts as specified above. Identification of the main categories and subcategories of these decisional conflicts may be useful for the future development of decision-making support for men undergoing ART.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"407"},"PeriodicalIF":1.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}