BMC Research Notes最新文献

{"title":"Correction: Analysis of T-DNA alleles of flavonoid biosynthesis genes in Arabidopsis ecotype Columbia.","authors":"Peter A Bowerman, Melissa V Ramirez, Michelle B Price, Richard F Helm, Brenda S J Winkel","doi":"10.1186/s13104-025-07316-x","DOIUrl":"https://doi.org/10.1186/s13104-025-07316-x","url":null,"abstract":"","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"338"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of lipid accumulation product in patients with type 2 diabetes mellitus and heart failure with reduced ejection fraction: a retrospective cohort study.","authors":"Hao Wang, Xiaoli Ma, Dan Zhang, Shunmin Liu, Xiang Ma, Xiang Zhao","doi":"10.1186/s13104-025-07405-x","DOIUrl":"https://doi.org/10.1186/s13104-025-07405-x","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate lipid accumulation product (LAP) as a predictor of all-cause mortality in type 2 diabetes mellitus (T2DM) patients with heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Results: </strong>Among 926 T2DM-HFrEF patients followed for 29.9 months (median), high LAP independently predicted increased mortality risk (adjusted HR: 3.102, 95% CI 2.142-4.491; P < 0.001). LAP exhibited a nonlinear association with mortality (P for Nonlinear < 0.001) and demonstrated moderate predictive accuracy (AUC = 0.643, 95% CI 0.602-0.684).</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"335"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral alveolar macrophages express more ACE2 immunoreactivity than in hilar area in human autopsied lung.","authors":"Makoto Nogami, Hiromi Mutsuro-Aoki, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai, Tadashi Nishio","doi":"10.1186/s13104-025-07292-2","DOIUrl":"https://doi.org/10.1186/s13104-025-07292-2","url":null,"abstract":"","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"336"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time analysis of Delphi panel data to facilitate iterative rating within meetings.","authors":"Julien B Weinstein, Cainnear K Hogan, Taylor Whittington, Jennifer Cano, Sarah M Seelye, Jeremy B Sussman, Steven J Bernstein, Hallie C Prescott","doi":"10.1186/s13104-025-07409-7","DOIUrl":"https://doi.org/10.1186/s13104-025-07409-7","url":null,"abstract":"<p><strong>Objective: </strong>The Modified Delphi panel process involves iterative ratings, often with lengthy lags between rounds to allow time for data analysis. We sought to develop, implement, and evaluate an approach for real-time data analysis and presentation to complete multiple rounds of ratings in a single panel meeting.</p><p><strong>Results: </strong>We developed statistical code in Python to analyze Delphi panel ratings completed in Slido using a 9-point Likert scale. The code generates histograms of panel ratings. The median score is color-coded pink when formal disagreement criteria are met (regardless of median score), and when there is no disagreement, red for median scores of 1-3, yellow for 4-6, and green for 7-9. We implemented this approach for a Delphi panel on sepsis recovery that rated three sets of care practices. Round 1 rating, panel discussion, and round 2 rating all occurred in one day for each set of practices. Round 1 ratings were presented during discussion. This approach avoided \"homework\" outside meetings. All panelists either strongly agreed (57%) or agreed (43%) it was easy to understand the presentation of round 1 ratings. Most panelists either strongly agreed (50%) or agreed (21%) that they liked doing both rounds of rating during the meetings.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"337"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of two types of exercise conditioning on hypothalamic corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GNRH) gene expression response to acute noise stress in rats.","authors":"Mohammadamin Safari, Elaheh Farahbakht, Alireza Sharifabadi, Hosein Sepehri, Maryam Koushkie Jahromi","doi":"10.1186/s13104-025-07365-2","DOIUrl":"https://doi.org/10.1186/s13104-025-07365-2","url":null,"abstract":"<p><p>This study investigated the effect of two types of exercise on the hypothalamic expression of CRH and GnRH genes in response to acute noise stress in young rats. 42 male Wistar rats were divided into 7 groups including control (Con), Control Time (CT), acute noise stress (S), Moderate-intensity Continuous Training (MCT), High-Intensity Interval Training (HIIT), MCT + noise stress (MS), and HIIT + noise stress (HS). Exercise raining was performed for eight weeks. Noise stress was induced for one session. Hippocampus samples were taken 48 h following eight weeks in exercise training groups (MCT and HIIT) as well as CT and just after noise stress in related groups (S, HS, and MS). One-way analysis of variance (ANOVA) was used to compare the groups. CRH expression was significantly higher in the HIIT group while was significantly lower in the MCT group compared to the CT group (P = 0.0001). GnRH expression was significantly lower in the HIIT group than the MCT group; it was significantly higher in MCT group than the CT group (P = 0.0001). CRH expression increased in S group (P = 0.0001); it was significantly lower in HS and MS groups than in S group. CRH expression was significantly higher while, GnRH expression was significantly lower in the MS group compared to MCT group (P = 0.0001). So, HIIT inhibited GnRH and increased CRH while MCT increased GnRH and inhibited CRH gene expression. HIIT and MCT training, in that order, were effective in reducing the effects of noise stress.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"341"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A functional complementation of a cotton MIZU-KUSSEI1 homolog in the hydrotropism response of Arabidopsis thaliana roots.","authors":"Su-Hwan Kwak, Wonkeun John Park","doi":"10.1186/s13104-025-07345-6","DOIUrl":"https://doi.org/10.1186/s13104-025-07345-6","url":null,"abstract":"<p><strong>Objective: </strong>Plants control the direction of root growth toward moisture due to their sessile nature, a phenomenon known as hydrotropism. In Arabidopsis thaliana, the MIZU-KUSSEI1 (MIZ1) protein is essential for the hydrotropic response. To investigate the molecular mechanism of hydrotropism in cotton, we examined the function of GhMIZ1, the closest homolog of Arabidopsis thaliana MIZ1.</p><p><strong>Results: </strong>The GhMIZ1 gene, amplified from Gossypium hirsutum genomic DNA, was introduced into the Arabidopsis thaliana miz1 null mutant genome. Hydrotropism response in the transgenic mutant roots overexpressing GhMIZ1 was tested by using split-agarose plates containing 20% sorbitol. The expression of GhMIZ1 partially restored the hydrotropic response in miz1 mutant roots. This finding suggests that GhMIZ1 is capable of mediating hydrotropism in Arabidopsis thaliana, indicating that it serves as a functional homolog of MIZU-KUSSEI1.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"340"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of dentists' knowledge and awareness of oral manifestations of COVID-19 and the impact of pandemic waves on dental practice in India - an embedded study.","authors":"Swati Bhatnagar, Shushma Rao B, Rahul Srivastava, Niharicka Gopalakrishnan, Ramya Shenoy, Roma Mascarenhas","doi":"10.1186/s13104-025-07367-0","DOIUrl":"https://doi.org/10.1186/s13104-025-07367-0","url":null,"abstract":"<p><strong>Background: </strong>The cross-infection created between dental staff and patients by COVID-19 had no established protocols for the dental problems caused by the pandemic. Hence, the dentists' knowledge regarding the oral symptoms of COVID-19 were assessed.</p><p><strong>Objective: </strong>This study reviewed the knowledge regarding oral manifestations of COVID-19 among dentists and the effect of waves 1 and 2 on dental community.</p><p><strong>Methods: </strong>In phase I, a cross-sectional survey with standardised and validated questionnaire was distributed among dentists using social media. In phase II, a qualitative in-depth interview of 8 dental clinicians (samples due to data saturation) was done to investigate the effects waves 1 and 2 on dentistry. Descriptive data was analysed via chi-square tests and Phase II analysis was carried out via Atlas-Ti software.</p><p><strong>Results: </strong>About 84.4% dental surgeons, 15 (3.7%) BDS, 48 (11.9%) MDS aspirants had good knowledge about the basic details and the oral manifestations of COVID-19, and the results were statistically significant with the participants' knowledge about COVID-19 (p = 0.001), oral manifestations (p = 0), recommended personal prevention (p = 0.01), the necessity of RT‒PCR (p = 0) and disease fatality (p = 0.015). In phase II, four themes were formed from interviews: Source of 1st information, Outlook towards COVID-19, Impact and Self-retrospection.</p><p><strong>Conclusion: </strong>This study highlights the knowledge assessment among dental clinicians on the requirement of educational training programs about infection control practices to be followed in dentistry. The in-depth interviews of the dental clinicians revealed the need for strict infection control protocols following the pandemic.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"342"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of empagliflozin and sitagliptin, as an add-on to metformin, on cardio-metabolic and glycemic parameters of patients with type 2 diabetes mellitus: a randomized, double-blind clinical trial.","authors":"Naimeh Mesri Alamdari, Maryam Barghaman, Neda Roshanravan, Majid Mobasseri, Helda Tutunchi, Amir Baharami, Akbar Aliasgarzadeh, Vahideh Sadra","doi":"10.1186/s13104-025-07214-2","DOIUrl":"https://doi.org/10.1186/s13104-025-07214-2","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of empagliflozin, sitagliptin, and metformin on the glycemic indices and cardiometabolic control of patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Results: </strong>The significant changes in FBS from baseline to week 12 were - 23.1, -16.15, and - 15.25 mg/dl in the empagliflozin, sitagliptin, and metformin arm, respectively. HbA1C decreased significantly from baseline to week 12 in the empagliflozin, sitagliptin, and metformin arm (-1.8, -1.35, -0.69%). The FBS and HbA1C changes were significant in the empagliflozin group compared to the metformin group (P = 0.027, P = 0.037, respectively). The weight changes were substantial in the empagliflozin group relative to the metformin group (-4.1 vs. -0.90 kg; p = 0.044). Compared with the metformin group, the adjusted mean difference in the empagliflozin group was - 12.91 mg/dl (95% CI: 31.82, 6; P = 0.001) for triglyceride (TG) levels and 6.47 mg/dl (95% CI: 2.93, 10.01; P = 0.010) for high-density lipoprotein (HDL-c) levels. Moreover, empagliflozin led to reductions in SBP about - 8.27 mm Hg (95% CI: -13.31, -3.23; P = 0.001) and in DBP about - 13.37 mm Hg (95% CI: -16.42, -10.32; P = 0.001) compared with metformin.</p><p><strong>Trail registration number: </strong>IRCT. ir (IRCT20191231045959N1).</p><p><strong>Trail registration date: </strong>2020-01-19.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"339"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to improve academic motivation in undergraduate nursing students in Iran: a qualitative content analysis.","authors":"Mozhdeh Taheri Afshar, Arash Ziapour, Fakhreddin Chaboksavar, Shakiba Lajmiri, Murat Yıldırım, Fatemeh Mohammadkhah","doi":"10.1186/s13104-025-07322-z","DOIUrl":"10.1186/s13104-025-07322-z","url":null,"abstract":"<p><strong>Background: </strong>Academic motivation of nursing students is a broad and multidimensional concept that is a factor in achieving academic success, better quality of learning, creativity, academic satisfaction, reducing anxiety, continuing education and training competent nurses. The most important barrier to learning in nursing education environments is the lack of interest and motivation among students. This study aimed to explore ways to improve academic motivation in nursing students.</p><p><strong>Methods: </strong>This qualitative study was conducted in Ramsar City in 2023. A conventional qualitative content analysis was followed to collect data using 14 in-depth individual interviews over a period of 12 months with participants selected through purposive sampling. For data analysis, Lundman and Granheim's method was adopted.</p><p><strong>Results: </strong>Data analysis led to the extraction of 143 codes, 14 subcategories, 3 categories, and one theme. Strategies to improve academic motivation in nursing students were found to be a subjective, dynamic and multi-dimensional concept divided into two categories: \"Improving educational conditions and performance\" and \"Improving students' welfare and recreational conditions\".</p><p><strong>Conclusion: </strong>Academic motivation is considered one of the essentials of learning and a tool to achieve educational and training goals. By using the strategies to increase academic motivation resulting from this study, an effective step can be taken in this field. Also Understanding these influential strategies can play a significant role in educational and career planning and decision-making, selecting appropriate educational and clinical measures and facilities in the university and students' future work environment, developing educational and career regulations, effective interaction with learners, ultimately increasing the effectiveness of professors' teaching and better teaching and learning activities.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"334"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Work limitations, business maintenance, and demoralization in self-employed individuals with cardiac diseases.","authors":"Wafaa Sowan, Sabaa Masarwe","doi":"10.1186/s13104-025-07402-0","DOIUrl":"10.1186/s13104-025-07402-0","url":null,"abstract":"<p><strong>Objective: </strong>Self-employed individuals managing chronic illnesses such as cardiac diseases are at heightened risk for psychological distress. This study aimed to examine the relationship between work limitations resulting from cardiac disease and demoralization, and to test whether the perceived difficulty of maintaining one's business mediates this association.</p><p><strong>Results: </strong>Greater work limitations were associated with higher levels of demoralization among self-employed individuals with cardiac disease. This relationship was partially mediated by the perceived difficulty in maintaining one's business. The findings highlight the psychological burden tied to occupational instability in the context of chronic illness. These results suggest the need for targeted support services and policy interventions to address the specific vulnerabilities of self-employed individuals facing health challenges.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"331"},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}