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The abnormally increased functional connectivity of the locus coeruleus in migraine without aura patients. 无先兆偏头痛患者的小脑位置功能连接异常增强。
IF 1.6
BMC Research Notes Pub Date : 2024-11-06 DOI: 10.1186/s13104-024-06991-6
Bangli Shen, Jinming Cheng, Xi Zhang, Xiaoyuan Wu, Zhihong Wang, Xiaozheng Liu
{"title":"The abnormally increased functional connectivity of the locus coeruleus in migraine without aura patients.","authors":"Bangli Shen, Jinming Cheng, Xi Zhang, Xiaoyuan Wu, Zhihong Wang, Xiaozheng Liu","doi":"10.1186/s13104-024-06991-6","DOIUrl":"10.1186/s13104-024-06991-6","url":null,"abstract":"<p><strong>Background: </strong>The neurovascular theory is thought to be one of the main pathological mechanisms of migraine. Locus coeruleus (LC) is a major node in the neurovascular pathway. Exploring the functional network characteristics of LC in migraine without aura (MwoA) patients can help us gain insight into the underlying neural mechanisms in MwoA patients.</p><p><strong>Methods: </strong>In this study, we used resting-state functional magnetic resonance imaging (rsfMRI) and a functional connectivity (FC) approach to explore the functional characteristics of LC in MwoA patients. 17 healthy controls (HCs) and 28 MwoA patients were included in the study. FC was calculated based on rsfMRI data collected by a 3T MRI scanner. General linear model were used to compare whether there were differences in LC brain networks between the two groups. We also utilized logistic regression to explore the role of LC functional networks in the clinical diagnosis of MwoA.</p><p><strong>Results: </strong>After general linear analysis, MwoA patients displayed increased FC from right LC to the left lingual and calcarine sulcus, as well as to the right frontal medial gyrus/orbit part, when compared with HCs. The results of the logistic regression showed that the LC FC signals were 81% accurate in distinguishing MwoA from the HCs.</p><p><strong>Conclusion: </strong>Our results demonstrated that patients with MwoA exhibited significant LC FC differences in the brain areas associated with visual and cognitive function. Understanding the changes in the LC brain network in MwoA patients can provide us with new ideas to understand the pathological mechanisms of MwoA.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The bone Gla protein osteocalcin is expressed in cranial neural crest cells. 骨 Gla 蛋白骨钙素在颅神经嵴细胞中表达。
IF 1.6
BMC Research Notes Pub Date : 2024-11-05 DOI: 10.1186/s13104-024-06990-7
Rotem Kalev-Altman, Veatriki Fraggi-Rankis, Efrat Monsonego-Ornan, Dalit Sela-Donenfeld
{"title":"The bone Gla protein osteocalcin is expressed in cranial neural crest cells.","authors":"Rotem Kalev-Altman, Veatriki Fraggi-Rankis, Efrat Monsonego-Ornan, Dalit Sela-Donenfeld","doi":"10.1186/s13104-024-06990-7","DOIUrl":"10.1186/s13104-024-06990-7","url":null,"abstract":"<p><strong>Background: </strong>Osteocalcin is a small protein abundant in the bone extracellular-matrix, that serves as a marker for mature osteoblasts. To become activated, osteocalcin undergoes a specific post-translational carboxylation. Osteocalcin is expressed at advanced stages of embryogenesis and after birth, when bone formation takes place. Neural crest cells (NCCs) are a unique cell population that evolves during early stages of development. While initially NCCs populate the dorsal neural-tube, later they undergo epithelial-to-mesenchymal-transition and migrate throughout the embryo in highly-regulated manner. NCCs give rise to multiple cell types including neurons and glia of the peripheral nervous system, chromaffin cells and skin melanocytes. Remarkably, in the head region, NCCs give rise to cartilage and bone.</p><p><strong>Finding: </strong>Here we report that osteocalcin is detected in cranial NCCs. Analysis of chick embryos at stages of cranial NCC migration revealed that osteocalcin mRNA and protein is expressed in pre-migratory and migratory NCCs in-vivo and ex-vivo. Addition of warfarin, an inhibitor of osteocalcin carboxylation, onto neural-tube explants, reduced the amount of NCC migration. These results provide the first evidence of osteocalcin presence in cranial NCCs, much before they give rise to craniofacial skeleton, and propose its possible involvement in the regulation of NCC migration.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria patients from a Ghanaian case-control study. 加纳病例对照研究中无并发症疟疾儿科患者的白细胞介素-4 及其受体α。
IF 1.6
BMC Research Notes Pub Date : 2024-10-31 DOI: 10.1186/s13104-024-06984-5
Patrick Diaba-Nuhoho
{"title":"Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria patients from a Ghanaian case-control study.","authors":"Patrick Diaba-Nuhoho","doi":"10.1186/s13104-024-06984-5","DOIUrl":"10.1186/s13104-024-06984-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated gene polymorphisms in the interleukin-4 (IL-4) and its receptor alpha (IL-4Rα) gene regions in human hosts with uncomplicated malaria.</p><p><strong>Data description: </strong>Blood samples were obtained from a case-control study conducted at the Sogakope district hospital in the Volta region of Ghana. Thick blood films were made and used to detect the presence and levels of parasitaemia in the patient samples. Genotyping of IL-4 (150 C/T) and the IL-4Rα (Pro-478-Ser) polymorphisms in the promoter regions and receptor gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) after DNA extraction. The data are useful in determining genetic polymorphisms (allele and genotypic frequencies) of IL-4 and its alpha receptor. In addition, they are useful when comparing levels of parasite density and haematological parameters between genotypic variants of IL-4 and IL-4Rα. These data contribute to our understanding of the genetic basis of malaria susceptibility, particularly in the population of the Volta region of Ghana.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Starch granules in algal cells play an inherent role to shape the popular SSC signal in flow cytometry. 藻类细胞中的淀粉粒在流式细胞仪中对形成流行的 SSC 信号起着固有的作用。
IF 1.6
BMC Research Notes Pub Date : 2024-10-29 DOI: 10.1186/s13104-024-06983-6
Michael Sandmann, Michael Rading
{"title":"Starch granules in algal cells play an inherent role to shape the popular SSC signal in flow cytometry.","authors":"Michael Sandmann, Michael Rading","doi":"10.1186/s13104-024-06983-6","DOIUrl":"10.1186/s13104-024-06983-6","url":null,"abstract":"<p><strong>Objective: </strong>Flow cytometry (FC) is probably the most important technique for single-cell analysis. It's precisely, rapid, and suitable for multidimensional single-cell analysis. The commonly used side scatter (SSC) intensity determined by FC is often interpreted as a measure of the internal cellular complexity of cells. In simple terms, the more structured a cell is, the higher the SSC intensity quantified by FC. Nevertheless, most of the studies that support this interpretation are based on data derived from animal or human cell lines and while it is assumed that the results can also be transferred to plant or algal cell lines, the details remain unclear. The objective of the recent work is to clarify the interpretation of the SSC signal from algal cells.</p><p><strong>Results: </strong>Algal lipid droplets and their starch play an inherent role to shape the popular SSC signal derived from FC. This was shown by a theoretical approach based on Lorenz-Mie theory. These results were supported by experiments with different model cultures of Chlamydomonas reinhardtii in which a high linear correlation was observed between the SSC signal and the 'physical' starch quantity.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population structure of Desmophyllum pertusum found along the United States eastern continental margin. 美国东部大陆边缘发现的 Desmophyllum pertusum 的种群结构。
IF 1.6
BMC Research Notes Pub Date : 2024-10-29 DOI: 10.1186/s13104-024-06977-4
Alexis M Weinnig, Aaron W Aunins, Veronica Salamone, Andrea M Quattrini, Martha S Nizinski, Cheryl L Morrison
{"title":"Population structure of Desmophyllum pertusum found along the United States eastern continental margin.","authors":"Alexis M Weinnig, Aaron W Aunins, Veronica Salamone, Andrea M Quattrini, Martha S Nizinski, Cheryl L Morrison","doi":"10.1186/s13104-024-06977-4","DOIUrl":"10.1186/s13104-024-06977-4","url":null,"abstract":"<p><strong>Objective: </strong>The connectivity and genetic structuring of populations throughout a region influence a species' resilience and probability of recovery from anthropogenic impacts. By gaining a comprehensive understanding of population connectivity, more effective management can be prioritized. To assess the connectivity and population genetic structure of a common cold-water coral species, Desmophyllum pertusum (Lophelia pertusa), we performed Restriction-site Associated DNA Sequencing (RADseq) on individuals from nine sites ranging from submarine canyons off New England to the southeastern coast of the United States (SEUS) and the Gulf of Mexico (GOM). Fifty-seven individuals and 3,180 single-nucleotide polymorphisms (SNPs) were used to assess genetic differentiation.</p><p><strong>Results: </strong>High connectivity exists among populations along the SEUS, yet these populations were differentiated from those to the north off New England and in Norfolk Canyon along the North Atlantic coast of the United States, as well as those in the GOM. Interestingly, Norfolk Canyon, located just north of North Carolina, and GOM populations exhibited low levels of genetic differentiation, corroborating previous microsatellite analyses and signifying gene flow between these populations. Increasing sample sizes from existing populations and including additional sampling sites over a larger geographic range would help define potential source populations and reveal fine-scale connectivity patterns among D. pertusum populations.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empirical dietary inflammatory pattern could increase the odds of breast cancer: a case-control study. 经验性膳食炎症模式可增加乳腺癌发病几率:一项病例对照研究。
IF 1.6
BMC Research Notes Pub Date : 2024-10-28 DOI: 10.1186/s13104-024-06985-4
Masoud Amini Kahrizsangi, Pegah Hadi Sichani, Zainab Shateri, Ava Mashoufi, Mehran Nouri, Hossein Firoozbakht, Bahram Rashidkhani
{"title":"Empirical dietary inflammatory pattern could increase the odds of breast cancer: a case-control study.","authors":"Masoud Amini Kahrizsangi, Pegah Hadi Sichani, Zainab Shateri, Ava Mashoufi, Mehran Nouri, Hossein Firoozbakht, Bahram Rashidkhani","doi":"10.1186/s13104-024-06985-4","DOIUrl":"10.1186/s13104-024-06985-4","url":null,"abstract":"<p><strong>Background: </strong>It has been shown that chronic inflammation is a significant factor in cancer development and progression. The current study aimed to investigate whether a higher score on the empirical dietary inflammatory pattern (EDIP), which indicates a more pro-inflammatory diet, is related to higher odds of breast cancer in Iranian women.</p><p><strong>Methods: </strong>In the present case-control study, subjects in the case (n = 133) and control (n = 265) groups were chosen from the hospitals in Tehran, Iran. The cases consisted of women with newly diagnosed breast cancer, while the controls were selected from other parts of the same hospital and had no history of cancer or hormone therapy. Individuals whose reported energy intake deviated by three standard deviations above or below the mean energy intake of the population were excluded from the study. A reliable and valid semi-quantitative food frequency questionnaire was used to determine the participants' dietary intake. Additionally, the association between breast cancer and EDIP was evaluated by logistic regression analysis in both crude and adjusted models.</p><p><strong>Results: </strong>The median scores of EDIP in the case and control groups were 0.65 and 0.61, respectively. The findings also indicated that, in the adjusted model, the odds of developing breast cancer significantly increased in the last tertile of EDIP compared to the first tertile (odds ratio (OR) = 1.859; 95% confidence interval (CI): 1.059-3.265; P = 0.031). Additionally, after adjusting for potential confounders, higher odds of breast cancer were observed in the last tertile of EDIP compared to the first tertile in postmenopausal women (OR = 2.516; 95% CI: 1.081-5.856; P = 0.033).</p><p><strong>Conclusions: </strong>The current study indicated that individuals with a higher pro-inflammatory diet score were more likely to develop breast cancer.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19. 无声的预测因子:探索 galectin-3 和 Irisin 在严重 COVID-19 中的作用。
IF 1.6
BMC Research Notes Pub Date : 2024-10-27 DOI: 10.1186/s13104-024-06978-3
Valentina N Nikolic, Višeslav Popadic, Slobodan M Jankovic, Nenad Govedarović, Stevan Vujić, Jelica Andjelković, Lazar S Stosic, Nikola Č Stevanović, Marija Zdravkovic, Zoran Todorovic
{"title":"The silent predictors: exploring galectin-3 and Irisin's tale in severe COVID-19.","authors":"Valentina N Nikolic, Višeslav Popadic, Slobodan M Jankovic, Nenad Govedarović, Stevan Vujić, Jelica Andjelković, Lazar S Stosic, Nikola Č Stevanović, Marija Zdravkovic, Zoran Todorovic","doi":"10.1186/s13104-024-06978-3","DOIUrl":"10.1186/s13104-024-06978-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the roles of galectin-3 and irisin as biomarkers in predicting severe outcomes in COVID-19 patients.</p><p><strong>Results: </strong>We analyzed serum levels of galectin-3 and irisin in 59 patients with severe COVID-19 and 30 healthy controls. Elevated galectin-3 levels were associated with increased risks of mortality, need for intensive care, and severe acute respiratory distress syndrome. The optimal cut-off value for galectin-3 was 13.47 ng/ml, with a sensitivity of 72.7% and specificity of 76.6%. Irisin levels did not differ significantly between survivors and non-survivors at admission or on the 3rd day post-admission, but approached significance on the 7th day. These findings suggest that galectin-3 could be a valuable prognostic biomarker for severe COVID-19 outcomes, while irisin's role remains to be clarified in further studies.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological analysis of pediculosis and the distribution of kdr mutation frequency in head lice populations in Torbat Heydarieh city of Khorasan Razavi Province, Northeastern Iran. 伊朗东北部呼罗珊拉扎维省 Torbat Heydarieh 市头虱病流行病学分析及 kdr 变异频率分布。
IF 1.6
BMC Research Notes Pub Date : 2024-10-25 DOI: 10.1186/s13104-024-06940-3
Mohammad Taheri, Fereshteh Ghahvechi Khaligh, Ahmad Ali Hanafi-Bojd, Hamid Reza Khalkhali, Kamal Dashti, Mehdi Badakhshan, Saber Gholizadeh
{"title":"Epidemiological analysis of pediculosis and the distribution of kdr mutation frequency in head lice populations in Torbat Heydarieh city of Khorasan Razavi Province, Northeastern Iran.","authors":"Mohammad Taheri, Fereshteh Ghahvechi Khaligh, Ahmad Ali Hanafi-Bojd, Hamid Reza Khalkhali, Kamal Dashti, Mehdi Badakhshan, Saber Gholizadeh","doi":"10.1186/s13104-024-06940-3","DOIUrl":"10.1186/s13104-024-06940-3","url":null,"abstract":"<p><p>Head lice infestations are the most prominent ectoparasitic infection in the world, including Iran, particularly among school children. Recently, numerous cases of infestation have been reported in various provinces of the country. This study aimed to investigate the prevalence of head louse infestations and analyze kdr gene sequences in terms of resistance mutations in the Torbat-e Heydarieh, Mahvelat, and Zaveh cities of Khorasan Razavi Province, Northeast Iran. The data related to the epidemiological and demographic history of head lice populations were extracted from their medical records and analyzed in Excel software. After extracting the genomic DNA, the kdr fragment was amplified using specific primers. The sequences were also analyzed using bioinformatics software. The prevalence of head louse infestations was 1.59% and 1.7% during 2016 and 2017, respectively. Sequence analysis revealed the frequency distribution of two kdr haplotypes, I and V, in the study areas. The increase in head louse infestations in recent years and the simultaneous presence of kdr mutations indicate the need for new treatments and monitoring/controlling resistance to head louse insecticides.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic burden of sarcopenia-related disability in the elderly population: a study in Iran. 老年人因肌肉疏松症而致残的经济负担:伊朗的一项研究。
IF 1.6
BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06975-6
Ali Darvishi, Adeleh Nikkhah, Gita Shafiee, Rajabali Daroudi, Ramin Heshmat
{"title":"Economic burden of sarcopenia-related disability in the elderly population: a study in Iran.","authors":"Ali Darvishi, Adeleh Nikkhah, Gita Shafiee, Rajabali Daroudi, Ramin Heshmat","doi":"10.1186/s13104-024-06975-6","DOIUrl":"10.1186/s13104-024-06975-6","url":null,"abstract":"<p><strong>Objective: </strong>Sarcopenia is linked to escalating health costs, heightened risk of physical disability, diminished quality of life and an increased demand for care services. This study aimed to assess the economic impact of sarcopenia-related disability in Iran. A prevalence-based economic burden study was conducted utilizing the Population Attributable Risk (PAR) method, based on 2022 price index. Prevalence data for sarcopenia, categorized by gender and disease severity, were extracted from recent comprehensive studies. The relative risk of sarcopenia disability was determined from the most robust available evidence. Subsequently, direct medical costs, direct non-medical costs, and indirect costs for each individual with sarcopenia were computed and adjusted to 2022 values to estimate disability costs.</p><p><strong>Results: </strong>Taking into account the prevalence of sarcopenia and the Iranian population across various age groups, 2,192,168 adults aged ≥ 60 years with sarcopenia in Iran were included. The total PAR of sarcopenia for men and women was estimated at 49% and 28%, respectively. The cumulative direct medical costs, direct non-medical costs, and indirect costs amounted to $215.1 million, $7.76 million, and $34.1 million, respectively. Additionally, the average total economic burden of sarcopenia-related disability in Iranian population aged ≥ 60 years was estimated at $257.1 million.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lack of Candida africana in Ugandan pregnant women: results from a pilot study using MALDI-ToF. 乌干达孕妇体内缺乏非洲念珠菌:使用 MALDI-ToF 进行试点研究的结果。
IF 1.6
BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06973-8
Bwambale Jonani, Herman Roman Bwire, Charles Emmanuel Kasule, Gerald Mboowa
{"title":"Lack of Candida africana in Ugandan pregnant women: results from a pilot study using MALDI-ToF.","authors":"Bwambale Jonani, Herman Roman Bwire, Charles Emmanuel Kasule, Gerald Mboowa","doi":"10.1186/s13104-024-06973-8","DOIUrl":"https://doi.org/10.1186/s13104-024-06973-8","url":null,"abstract":"<p><strong>Background: </strong>Candida africana is an emergent variant that has been listed as a new species or variety within the Candida albicans complex since 2001. It has a worldwide intra-albicans complex pooled prevalence of 1.67% and varies between 0 and 8% depending on geographical region. We present the results of a pilot study on its prevalence in Uganda.</p><p><strong>Methodology: </strong>We conducted a cross-sectional study between March and June 2023. We recruited 4 pregnant women from Mulago Specialized Women and Neonatal Hospital, 102 from Kawempe National Referral Hospital, and 48 from Sebbi Hospital. Vaginal swabs were tested using microscopy, culture and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF).</p><p><strong>Results: </strong>The prevalence of C. africana was zero. Out of the 103 isolates, the majority (81.553%) were identified as Candida albicans, followed by Nakeseomyces glabrata (13.592%) and Pichia kudriavzevii (1.942%). Cyberlindnera jadinii, Candida tropicalis, and Candida parapsilosis each accounted for 0.971% of the isolates.</p><p><strong>Conclusion: </strong>The prevalence of C. africana in Uganda is zero. However, large-scale cross-sectional studies, including studies involving the collection of vaginal samples from both urban and rural settings in Uganda and the use of both MALDI-TOF- and PCR-based laboratory methods, are needed to fully describe the public health burden of C. africana infections.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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