BMC Research Notes最新文献

Production of functional recombinant antibodies in Dictyostelium discoideum. 盘状盘基架菌功能重组抗体的产生。

IF 1.6

BMC Research Notes Pub Date : 2025-06-04 DOI: 10.1186/s13104-025-07314-z

Cyril Guilhen, Tania Jauslin

引用次数: 0

A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia. 在埃塞俄比亚阿姆哈拉农村，单次假定的驱虫可能不足以减轻怀孕期间肠道寄生虫感染的负担。

IF 1.6

BMC Research Notes Pub Date : 2025-06-03 DOI: 10.1186/s13104-025-07309-w

Kalkidan Yibeltal, Firehiwot Workneh, Nebiyou Fasil, Estifanos Baye, Yunhee Kang, Workagegnhu Tarekegn Kidane, Sitota Tsegaye, Yoseph Yemane Berhane, Bethlehem Haymanot, Ingrid E Olson, Mulatu Melese Derebe, Rose L Molina, Blair J Wylie, Grace J Chan, Parul Christian, Alemayehu Worku, Anne Cc Lee, Yemane Berhane

{"title":"A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara, Ethiopia.","authors":"Kalkidan Yibeltal, Firehiwot Workneh, Nebiyou Fasil, Estifanos Baye, Yunhee Kang, Workagegnhu Tarekegn Kidane, Sitota Tsegaye, Yoseph Yemane Berhane, Bethlehem Haymanot, Ingrid E Olson, Mulatu Melese Derebe, Rose L Molina, Blair J Wylie, Grace J Chan, Parul Christian, Alemayehu Worku, Anne Cc Lee, Yemane Berhane","doi":"10.1186/s13104-025-07309-w","DOIUrl":"10.1186/s13104-025-07309-w","url":null,"abstract":"Objective: This study aimed to assess the prevalence of intestinal parasitic infections among pregnant women in the third trimester who received prior presumptive deworming in 12 health centers in the Amhara region, Ethiopia. This sub-study was part of the parent Enhancing Nutrition and Antenatal Infection Treatment (ENAT) study; a randomized clinical effectiveness study conducted to determine the effectiveness of packages of antenatal interventions to enhance maternal nutrition and infection management on birth outcomes.Results: Three hundred fifty women provided a stool sample in their 3rd trimester for screening using wet mount microscopy. All women had previously received 500 mg of presumptive mebendazole in the 2nd trimester. One in three women (109/350, 31.0%) were found to have a parasitic stool infection after prior deworming and 15% of women reported gastrointestinal symptoms. The most common infections were Giardia lamblia (n = 43, 37.4%), Entamoeba histolytica (n = 40, 34.8%), and Hookworm (n = 25, 21.7%). Six mothers had co-infections with at least two parasites with trophozoites of Giardia lamblia and Entamoeba histolytica co-infection being dominant.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"245"},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A psychometric evaluation of the parent version of the children's revised impact of event scale (CRIES): screening for post-traumatic stress disorder in Dutch children aged 3 to 7 years. 父母版儿童事件影响量表（哭声）的心理测量学评价：3 - 7岁荷兰儿童创伤后应激障碍筛查。

IF 1.6

BMC Research Notes Pub Date : 2025-06-03 DOI: 10.1186/s13104-025-07310-3

Mia P Kösters, Eva Verlinden, Maj R Gigengack, Hans M Koot

{"title":"A psychometric evaluation of the parent version of the children's revised impact of event scale (CRIES): screening for post-traumatic stress disorder in Dutch children aged 3 to 7 years.","authors":"Mia P Kösters, Eva Verlinden, Maj R Gigengack, Hans M Koot","doi":"10.1186/s13104-025-07310-3","DOIUrl":"10.1186/s13104-025-07310-3","url":null,"abstract":"Background: For the prevention and reduction of potentially harmful effects of childhood trauma, systematic screening for PTSD is a useful first step. Recently, the parent-reported versions of the widely used Children's Revised Impact of Event Scale (CRIES-P13/8) were evaluated with promising results in children aged 8-18 years. The present study psychometrically evaluated these tools as screeners for PTSD in 96 very young children (3-7 years) in the Netherlands.Methods: In addition to the CRIES-P13/8, the Diagnostic Infant and Preschool Assessment (DIPA) was administered to the parents of children exposed to trauma. Psychometric evaluation of the CRIES-P13/8 comprised structural validity, reliability, and criterion validity.Results: The bi-factor confirmatory factor analyses yielded generally poor fit, unidimensionality was established (≥ 0.87), internal consistency was sufficient (≥ 0.85). The demonstrated screening characteristics show that the CRIES-P13/8 differentiates reliably between children with and without (sub-threshold) PTSD as assessed by the Diagnostic Infant and Preschool Assessment (DIPA).Conclusions: The CRIES-P13/8 are adequate screeners, also in young children. In addition to the small number of items, this makes the CRIES-P13/8 a practical screener in the clinical and research setting. For each version, three cut-off scores are suggested, for full PTSD as well as subthreshold PTSD.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"244"},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals. 评估CometChip技术在非模式物种DNA损伤研究中的应用：海龟和哺乳动物不同的紫外线诱导反应。

IF 1.6

BMC Research Notes Pub Date : 2025-06-02 DOI: 10.1186/s13104-025-07285-1

Stephanie E Bulls, Elijah Finn, Peter Sykora, Vincent J Lynch, Paramahansa Pramanik, Scott Glaberman, Ylenia Chiari

{"title":"Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals.","authors":"Stephanie E Bulls, Elijah Finn, Peter Sykora, Vincent J Lynch, Paramahansa Pramanik, Scott Glaberman, Ylenia Chiari","doi":"10.1186/s13104-025-07285-1","DOIUrl":"10.1186/s13104-025-07285-1","url":null,"abstract":"Objective: We evaluated the feasibility of using the high-throughput CometChip to assess DNA damage in non-model species. Specifically, we measured UVA-induced damage in fibroblasts from five turtle and four mammalian species with diverse life histories and cancer rates.Results: Turtles exhibited significantly higher endogenous DNA damage than mammals but showed lower UVA-induced damage after both 2-min and 5-min exposures. At 5 min, bats exhibited the most DNA damage (21.3%), followed by mice (11.3%). Elephants showed intermediate responses (Asian: 6.49%, African: 3.58%), while all turtles remained below 3%, suggesting resilience to oxidative stress. Despite the assay's ability to detect DNA damage across species, several challenges emerged. Endogenous damage varied widely both within and between species. Differences in culture requirements between turtles and mammals limited experimental standardization. Additionally, characterizing species-specific responses is challenging, as multiple cell lines per species are often unavailable for non-model organisms, making it difficult to account for intraspecific variation. Addressing these limitations will be crucial for conducting robust comparative studies of DNA damage responses in future research.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"243"},"PeriodicalIF":1.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome. rs7041多态性与伊朗多囊卵巢综合征妇女不孕和复发性妊娠丢失的关系

IF 1.6

BMC Research Notes Pub Date : 2025-05-31 DOI: 10.1186/s13104-025-07312-1

Hediyeh Hamidi, Asma Kheirollahi, Akram Vatannejad

引用次数: 0

Barriers and facilitators to Parkinson's disease research participation amongst underrepresented groups. 在代表性不足的群体中参与帕金森病研究的障碍和促进因素。

IF 1.6

BMC Research Notes Pub Date : 2025-05-29 DOI: 10.1186/s13104-025-07293-1

Jennifer Adrissi, Anabel Marre, Maxwell Edwin Shramuk, Emily Zivin, Karen Williams, Danielle Larson

{"title":"Barriers and facilitators to Parkinson's disease research participation amongst underrepresented groups.","authors":"Jennifer Adrissi, Anabel Marre, Maxwell Edwin Shramuk, Emily Zivin, Karen Williams, Danielle Larson","doi":"10.1186/s13104-025-07293-1","DOIUrl":"10.1186/s13104-025-07293-1","url":null,"abstract":"Objective: Even though the growing prevalence of Parkinson's disease (PD) is inclusive of ethnic and racial minority groups, these populations remain underrepresented in PD clinical research. This community-based study seeks to add to the limited knowledge on barriers and facilitators to underrepresented group (URG) enrollment in PD trials by assessing minority community members' PD and research knowledge, trust in medical researchers, and likelihood to participate in research based on various study design factors.Results: Of the 97 total workshop participants, 80 completed demographic information, with the majority female (71%) and from minority racial groups -- African American/Black (37.5%) and East/Southeast Asian (45%). Levels of trust in medical researchers were generally high and improved post-workshop. Most respondents were likely to participate in trials requiring DNA or cognitive testing, and unlikely if requiring intravenous infusion or lumbar puncture. Facilitators to trial participation included offering transportation and financial incentives, while longer study visits and study duration were barriers.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"240"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial factors driving common substances used among Ghanaian senior high school students. 社会心理因素对加纳高中生常用药物使用的影响。

IF 1.6

BMC Research Notes Pub Date : 2025-05-29 DOI: 10.1186/s13104-025-07307-y

Rachael Asantewaa Darko, Franklin N Glozah

{"title":"Psychosocial factors driving common substances used among Ghanaian senior high school students.","authors":"Rachael Asantewaa Darko, Franklin N Glozah","doi":"10.1186/s13104-025-07307-y","DOIUrl":"10.1186/s13104-025-07307-y","url":null,"abstract":"Objective: Substance use among adolescents poses a significant public health challenge, particularly in low- and middle-income countries like Ghana. This study investigates the prevalence of substance use and its psychosocial correlates among in-school adolescents in Ghana, with the goal of identifying key risk and protective factors to inform culturally appropriate prevention and intervention strategies.Results: The findings revealed distinct patterns of substance use linked to social and familial influences. Male students, those living with relatives, and those with peers who drank alcohol had a higher likelihood of alcohol use. Students who engaged in part-time work or had family members who smoked were more likely to use cigarettes. Older adolescents and those with friends who used shisha showed increased shisha consumption. Notably, limited social media exposure and living with parents or siblings were associated with reduced marijuana use. Furthermore, students who reported substance use exhibited signs of potential substance use disorder. The study underscores the strong influence of peer and family substance use behaviours on adolescent substance uptake. These findings highlight the need for targeted, context-specific interventions that address psychosocial risk factors while reinforcing protective family and social dynamics to promote adolescent well-being in Ghana and similar settings.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"241"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gap in neurodegenerative disease care: a needs assessment for a Master's program in Sri Lanka. 弥合神经退行性疾病护理的差距：斯里兰卡硕士课程的需求评估。

IF 1.6

BMC Research Notes Pub Date : 2025-05-28 DOI: 10.1186/s13104-025-07305-0

Nirmala Rathnayake, Thamudi Sundarapperuma, Pramudika Nirmani, Bimba Wickramarachchi, Kumari De Silva, Prasanna Herath, Damayanthi Dassanayake, Sudath Warnakulasuriya, Martin Persson

{"title":"Bridging the gap in neurodegenerative disease care: a needs assessment for a Master's program in Sri Lanka.","authors":"Nirmala Rathnayake, Thamudi Sundarapperuma, Pramudika Nirmani, Bimba Wickramarachchi, Kumari De Silva, Prasanna Herath, Damayanthi Dassanayake, Sudath Warnakulasuriya, Martin Persson","doi":"10.1186/s13104-025-07305-0","DOIUrl":"10.1186/s13104-025-07305-0","url":null,"abstract":"Objective: Sri Lanka's aging population is contributing to a rising burden of neurodegenerative diseases (NDDs), exacerbated by limited care infrastructure and a shortage of trained professionals. To address this, Sri Lankan universities, through the EU-funded \"nEUROcare\" project, aim to develop a Master's program in NDD care. This mixed-method study surveyed 150 healthcare professionals and students, alongside Focus Group Discussions (FGDs) with 18 professionals, using pre-tested tools to assess knowledge, perceptions, and conduct a SWOT analysis.Results: Over half of the participants rated their knowledge of NDDs as above average, and 77.4% endorsed the need for a Master's program. Key motivators included career advancement and enhanced social recognition. Identified strengths were institutional and government support and the capacity of existing universities. Weaknesses included a lack of national policy, inadequate infrastructure, and insufficient trained teaching staff. Opportunities were seen in the demographic shift toward an aging population and the potential for economic and academic benefits. Threats included limited stakeholder awareness and funding constraints. The study clearly demonstrates the urgent need for specialized training in NDD care. Establishing a Master's program would significantly bridge current gaps in care, empower professionals, and improve outcomes for patients and their caregivers in Sri Lanka.Clinical trial number: Not applicable.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"238"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of radiology professionals' awareness of CT head artifacts. 放射科专业人员对CT头部伪影认知的调查。

IF 1.6

BMC Research Notes Pub Date : 2025-05-28 DOI: 10.1186/s13104-025-07300-5

Moawia Gameraddin, Awadia Gareeballah, Abdulaziz A Qurashi, Abdullah Fahad Alshamrani, Osama Ahmed Alasiri, Maher Mosfer Aljohani, Amel F Alzain, Omar Adel Almutairi, Abdulmalik Basheer Alenezi, Renad Albadrani, Awatif Omer, Maisa Elzaki, Abdalrahim Tagelsir Elsayed, Emadeldin Mohamed Mukhtar

{"title":"Investigation of radiology professionals' awareness of CT head artifacts.","authors":"Moawia Gameraddin, Awadia Gareeballah, Abdulaziz A Qurashi, Abdullah Fahad Alshamrani, Osama Ahmed Alasiri, Maher Mosfer Aljohani, Amel F Alzain, Omar Adel Almutairi, Abdulmalik Basheer Alenezi, Renad Albadrani, Awatif Omer, Maisa Elzaki, Abdalrahim Tagelsir Elsayed, Emadeldin Mohamed Mukhtar","doi":"10.1186/s13104-025-07300-5","DOIUrl":"10.1186/s13104-025-07300-5","url":null,"abstract":"Objective: Computerized tomography (CT) artifacts can happen for various causes. It is critical to understand these artifacts because they can mimic disease or reduce image quality to non-diagnostic levels. CT artifacts can be characterized according to their underlying cause. This study aims to evaluate and compare the understanding of CT head artifacts between radiographers and radiography interns, supplemented by insights from a select group of participating radiologists.Results: A cross-sectional survey study included 150 participants. All participants' average knowledge score of CT head artifact was good (77.81%). The most correctly identified CT head artifacts were the metal artifact (86%), ring artifact (84.7%), and motion artifact (81.3%). The beam hardening artifact was correctly identified less frequently (62%). There is significant difference in the recognition of motion artifacts among the participants (P = 0.001) knowledge of CT head image artifacts improved significantly with more experienced participants (P = 0.001), where participants with less than 10 months of experience had a higher rate of incorrect responses (85 incorrect vs. 31 correct). The recognition of these artifacts improves with experience and advanced age. Understanding these artifacts is essential to avoid misdiagnosis of various diseases.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"239"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of weighted low rank approximations: outlier detection in a data matrix. 加权低秩近似的应用：数据矩阵中的离群值检测。

IF 1.6

BMC Research Notes Pub Date : 2025-05-27 DOI: 10.1186/s13104-025-07284-2

Marisol García-Peña, Sergio Arciniegas-Alarcón, Kaye E Basford

{"title":"Application of weighted low rank approximations: outlier detection in a data matrix.","authors":"Marisol García-Peña, Sergio Arciniegas-Alarcón, Kaye E Basford","doi":"10.1186/s13104-025-07284-2","DOIUrl":"10.1186/s13104-025-07284-2","url":null,"abstract":"Objective: A mandatory step in the exploratory analysis of any rectangular database is the identification of possible outliers. The presence of these defines what type of explanatory and/or predictive modeling should be used subsequently. This paper presents strategies to identify outliers in any data set using weighted approximations of a matrix. The strategies are evaluated through artificial contamination in sixteen real data sets, of which two have multivariate characteristics and fourteen come from multi-environment trials. As an evaluation criterion, a statistic is proposed such that its value is small when the detection method is good and it is large when false positives or false negatives appear.Results: Six criteria for identifying outliers from weighted approximations were considered, including simple residuals, squared residuals with differential weights, Jackknife and their corresponding iterative versions, and they were compared with the gold standard one based on limits from a bias-adjusted boxplot. All methods are applicable to any numerical data set written in matrix form, e.g. experiments with genotype-by-environment interaction. It was found that in the presence of random outliers in a matrix with numerical entries, the identification of outliers using weighted approximations is more effective than detection based on limits from a bias-adjusted boxplot.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"234"},"PeriodicalIF":1.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0