BMC Research Notes最新文献

Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. 小细胞肺癌肿瘤和肿瘤微环境的成像细胞计数数据集。

IF 1.7

BMC Research Notes Pub Date : 2025-09-08 DOI: 10.1186/s13104-025-07460-4

France Rose, Olta Ibruli, Luca Lichius, Martha Kiljan, Gokcen Gozum, Manoela Iannicelli Caiaffa, Jiali Cai, Li-Na Niu, Jan M Herter, Holger Grüll, Reinhard Büttner, Filippo Beleggia, Graziella Bosco, Julie George, Grit S Herter-Sprie, Hans Christian Reinhardt, Katarzyna Bozek

{"title":"Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments.","authors":"France Rose, Olta Ibruli, Luca Lichius, Martha Kiljan, Gokcen Gozum, Manoela Iannicelli Caiaffa, Jiali Cai, Li-Na Niu, Jan M Herter, Holger Grüll, Reinhard Büttner, Filippo Beleggia, Graziella Bosco, Julie George, Grit S Herter-Sprie, Hans Christian Reinhardt, Katarzyna Bozek","doi":"10.1186/s13104-025-07460-4","DOIUrl":"10.1186/s13104-025-07460-4","url":null,"abstract":"Objectives: Small cell lung cancer (SCLC) accounts for approximately 15% of lung tumors and is marked by aggressive growth and early metastatic spread. In this study, we used two SCLC mouse models with differing tumor mutation burdens (TMB). To investigate tumor composition, spatial architecture, and interactions with the surrounding microenvironment, we acquired multiplexed images of mouse lung tumors using imaging mass cytometry (IMC). These data build upon a previously published characterization of the mouse model.Data description: After tumor detection, mice were assigned to one of five treatment groups. Lung tumor tissues were imaged with a 37-marker IMC panel designed to identify major cell types-tumor, immune, and structural-as well as their functional states. When possible, each tumor was sampled both at its center and border regions. Tumor masks in the form of binary images are provided to delineate tumor areas. Additional metadata include tumor onset and endpoint dates to support downstream correlation or predictive analyses based on the image data. This dataset offers a valuable resource for studying the histological and cellular complexity of SCLC in a genetically controlled mouse model across multiple therapeutic conditions.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"385"},"PeriodicalIF":1.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Randomized controlled trial to assess the effectiveness of apnoeic oxygenation in adults using a low-flow or high-flow nasal cannula with head side elevation during endotracheal intubation in the emergency department. 纠正：随机对照试验，以评估在急诊科气管插管期间使用低流量或高流量头侧抬高鼻插管的成人呼吸暂停氧合的有效性。

IF 1.7

BMC Research Notes Pub Date : 2025-09-08 DOI: 10.1186/s13104-025-07412-y

Shahan Waheed, Nazir Najeeb Kapadia, Rida Jawed, Ahmed Raheem, Muhammad Faisal Khan

引用次数: 0

Correction: Neuroathletic training in stroke rehabilitation? A single-blind randomized controlled pilot study on the potential of neuroathletic training for balance ability in stroke outpatient rehabilitation. 纠正：脑卒中康复中的神经运动训练？脑卒中门诊康复中神经运动训练对平衡能力潜力的单盲随机对照试验研究。

IF 1.7

BMC Research Notes Pub Date : 2025-09-04 DOI: 10.1186/s13104-025-07415-9

Judith Evers, Isabel Stolz, Marilena Klein

引用次数: 0

Metal profiling of Hass avocados: a cross-sectional study using ICP-MS and pXRF. 哈斯鳄梨的金属剖面分析：使用ICP-MS和pXRF的横断面研究。

IF 1.7

BMC Research Notes Pub Date : 2025-09-02 DOI: 10.1186/s13104-025-07430-w

Michael Anastario, Delaney Watkins, Aaron J Specht, Ashlyn Zilch, Cynthia Armendáriz Arnez, Courtney Roper

{"title":"Metal profiling of Hass avocados: a cross-sectional study using ICP-MS and pXRF.","authors":"Michael Anastario, Delaney Watkins, Aaron J Specht, Ashlyn Zilch, Cynthia Armendáriz Arnez, Courtney Roper","doi":"10.1186/s13104-025-07430-w","DOIUrl":"10.1186/s13104-025-07430-w","url":null,"abstract":"Objective: Metals in agricultural products can vary substantially based on numerous factors. This pilot study aimed to quantify metal concentrations in the mesocarp and exocarp of Hass avocados available to U.S. consumers using inductively coupled plasma mass spectrometry (ICP-MS), and to evaluate the feasibility of portable X-ray fluorescence (pXRF) as a rapid screening tool for elemental analysis.Results: Twenty-four elements were assessed across 24 avocado samples stratified by country of origin and agricultural practice. ICP-MS detected multiple metals-including K, Mg, Ca, Fe, Co, Ni, Zn, and Hg-with higher concentrations generally observed in the exocarp. Several elements exhibited strong co-occurrence patterns, such as Co-Ni in mesocarp and Mg-Fe-Mo-Hg in exocarp, with notable variation by source and farming method. Principal components and K-means clustering identified distinct metal mixture profiles. pXRF element counts correlated moderately with ICP-MS concentrations for K, Ca, Fe, and Zn, supporting its potential as a field-based prescreening method. These findings provide baseline data for environmental monitoring of avocados and illustrate the value of pXRF for future field-based biosocial and agricultural research.Clinical trial number: Not applicable.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"379"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Small Rubber Particle Protein 1 promoter from guayule (Parthenium argentatum). 银胶菊小橡胶颗粒蛋白1启动子的表征。

IF 1.7

BMC Research Notes Pub Date : 2025-09-02 DOI: 10.1186/s13104-025-07448-0

Grisel Ponciano, Niu Dong, Chen Dong, Kumiko Johnson, Tina Williams, Delilah F Wood, Grace Chen

引用次数: 0

Isolation and molecular characterization of bacteriophages isolated from lake water and their application in foods against Bacillus cereus. 湖水中噬菌体的分离、分子特性及其在食品中抗蜡样芽孢杆菌的应用。

IF 1.7

BMC Research Notes Pub Date : 2025-09-02 DOI: 10.1186/s13104-025-07436-4

Denny Rizkinata, Vania Clarissa Kusnadi, Diana Elizabeth Waturangi, Adi Yulandi

{"title":"Isolation and molecular characterization of bacteriophages isolated from lake water and their application in foods against Bacillus cereus.","authors":"Denny Rizkinata, Vania Clarissa Kusnadi, Diana Elizabeth Waturangi, Adi Yulandi","doi":"10.1186/s13104-025-07436-4","DOIUrl":"10.1186/s13104-025-07436-4","url":null,"abstract":"Objectives: Bacteriophages are viruses that specifically target and kill bacteria. Bacteriophages are considered safe for humans, making them suitable for use in food applications Therefore, this study was conducted to isolate, characterize, and apply bacteriophages from the environment to control food spoilage bacteria.Results: Bacteriophages were isolated by using Bacillus cereus (B. cereus) as reference host. We found bacteriophage BC-VP titers (1.16 ± 0.18 × 109 PFU/mL) and BC-AJ (1.72 ± 0.19 × 108 PFU/mL). Both bacteriophages were polyvalent, targeting not only B. cereus, but also lysing enteropathogenic Escherichia coli (EPEC) and enterotoxigenic Escherichia coli (ETEC) with different efficiencies. Bacteriophage BC-VP and BC-AJ miMOI were determined to be 0.01 and 1, respectively. Bacteriophage BC-VP morphology was analyzed using Transmission Electron Microscope (TEM) and categorized as Myoviridae family from the order of Caudovirales. Both bacteriophages showed significant bacterial reduction when applied to artificially contaminated cooked rice and pasteurized milk. The reduction number was higher in pasteurized milk at 28℃ for BC-VP (93%) and BC-AJ (90%). Molecular characterizations were performed and showed that BC-VP was 96.88% a virulent bacteriophage. Also, no sign of antibiotic resistance gene in BC-VP and genes related to lytic cycle such as putative tail lysin and tail fiber, were annotated.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"364"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring perceptions of vitamin D deficiency and cultural influences in people from minority ethnic groups aged 60 + in East London: a qualitative study. 探索东伦敦60岁以上少数民族人群对维生素D缺乏症的认知和文化影响：一项定性研究。

IF 1.7

BMC Research Notes Pub Date : 2025-09-01 DOI: 10.1186/s13104-025-07439-1

Charlotte Zheng, Ashlee Teakle, Rashpal Gill, Oyinlola Oyebode

{"title":"Exploring perceptions of vitamin D deficiency and cultural influences in people from minority ethnic groups aged 60 + in East London: a qualitative study.","authors":"Charlotte Zheng, Ashlee Teakle, Rashpal Gill, Oyinlola Oyebode","doi":"10.1186/s13104-025-07439-1","DOIUrl":"10.1186/s13104-025-07439-1","url":null,"abstract":"Objective: To explore the perceptions and attitudes of vitamin D deficiency (VDD) and cultural influences in people from minority ethnic groups aged 60 + in East London through thematic analysis of qualitative semi-structured interviews.Results: Nine participants were interviewed (7 in-person, 2 by phone). Participants were recruited by purposive and snowball sampling through East London organisations, local council authorities and website email contacts. A total of 4 themes were generated: vitamin D knowledge, sources of knowledge, barriers to vitamin D intake, and solutions to improve vitamin D intake. Solutions included 2 sub-themes: food fortification and supplementation, and education - further divided into (i) community and (ii) women as targets for education. There was some knowledge of vitamin D, however this was limited as few could name dietary sources of vitamin D. Barriers included cost of supplementation, accessibility to sunshine, and cultural factors (e.g. dietary behaviour, perceptions of sun exposure). Attitudes towards vitamin D supplementation were largely positive, whereas food fortification was more polarising. Targeted education was a suggested key solution, particularly within the community and amongst women - identified as a central figure in most families. Policy makers should engage communities and develop approaches that reflect the needs and characteristics of the population.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"378"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recruitment, retention and recouperation: lessons learned from a study aimed at assessing burnout mitigation in physician learners. 招聘、保留和补偿：从一项旨在评估医师学习者缓解职业倦怠的研究中获得的经验教训。

IF 1.7

BMC Research Notes Pub Date : 2025-09-01 DOI: 10.1186/s13104-025-07435-5

Jacqueline Pflaum-Carlson, Ashley Redding, Dana Murphy, Lisa MacLean, Julie Hamilton, Sara Santarossa

引用次数: 0

CD4 cell count and viral load count association and its joint risk factors among adult TB/HIV co-infected patients: a retrospective follow-up study. 成人TB/HIV合并感染患者CD4细胞计数和病毒载量计数的相关性及其联合危险因素：一项回顾性随访研究

IF 1.7

BMC Research Notes Pub Date : 2025-09-01 DOI: 10.1186/s13104-025-07428-4

Nurye Seid Muhie, Awoke Seyoum Tegegne

{"title":"CD4 cell count and viral load count association and its joint risk factors among adult TB/HIV co-infected patients: a retrospective follow-up study.","authors":"Nurye Seid Muhie, Awoke Seyoum Tegegne","doi":"10.1186/s13104-025-07428-4","DOIUrl":"10.1186/s13104-025-07428-4","url":null,"abstract":"Objective: The aim of this study was to determine CD4 cell count and viral load count association and its joint clinical risk factors among adult TB/HIV co-infected patients. The purpose of this research was leads to contribute improved planning and execution of screening programs, regular follow-ups, and prevention measures.Result: The baseline variability for viral load ([Formula: see text]) was higher than CD4 cell (819.797). Furthermore, the correlation matrix (R) shows that the baseline subject-specific CD4 cell and viral load were negatively correlated (- 0.[Formula: see text]). There was also a negative relationship between the subject-specific change CD4 cell and baseline viral load (-[Formula: see text]), subject-specific baseline CD4 cell, and the patient-specific change of viral load (-0.6513), longitudinal trajectory (association of evolution) for the two random slopes [Formula: see text]-0.9413). Then, there was very strong negative relationship between subject-specific change CD4 cell and viral load over time. Visit time[Formula: see text], white blood cell[Formula: see text], good[Formula: see text] and fair[Formula: see text]) adherence, hemoglobin ≥ 11 g/dl[Formula: see text], baseline CD4 cell ≥ 200 cells/mm3[Formula: see text], and baseline viral load < 10,000 copies/mL[Formula: see text]hematocrit[Formula: see text]and monocytes of patients[Formula: see text] were a joint determinates for viral load and CD4 cell, respectively.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"377"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart thin porous calcium phosphate coatings for local antibiotic delivery. 智能薄多孔磷酸钙涂层局部抗生素输送。

IF 1.7

BMC Research Notes Pub Date : 2025-09-01 DOI: 10.1186/s13104-025-07453-3

Long-Quan R V Le, Maria Carolina Lanzino, Anika Höppel, Mirjam Rech, Sofia Dembski, Andreas Killinger, Bianca Riedel, Michael Seidenstuecker

{"title":"Smart thin porous calcium phosphate coatings for local antibiotic delivery.","authors":"Long-Quan R V Le, Maria Carolina Lanzino, Anika Höppel, Mirjam Rech, Sofia Dembski, Andreas Killinger, Bianca Riedel, Michael Seidenstuecker","doi":"10.1186/s13104-025-07453-3","DOIUrl":"10.1186/s13104-025-07453-3","url":null,"abstract":"Objective: Implant failure after arthroplasty, primarily due to aseptic loosening or periprosthetic joint infection, remains a significant clinical problem. Bioactive ceramic coatings, such as β-tricalcium phosphate (β-TCP), enhance osseointegration and may reduce the risk of aseptic loosening. At the same time, localized antibiotic release from the implant surface represents a promising strategy to prevent early bacterial colonization. The aim of this study was to evaluate the feasibility of incorporating the heat-sensitive antibiotic vancomycin (VAN) into β-TCP coatings using high-velocity suspension flame spraying (HVSFS).Results: We successfully embedded VAN into β-TCP coatings by preparing suspensions containing VAN-loaded supraparticles as feedstock for the HVSFS process. High-performance liquid chromatography analysis confirmed that VAN maintained its chemical integrity during spraying, with spectra comparable to untreated controls, indicating no thermal degradation. The resulting multifunctional coatings therefore combined the osteoconductive potential of β-TCP with the antibacterial activity of VAN. These findings demonstrate that HVSFS is a viable technique for producing bioactive coatings that simultaneously promote bone integration and enable local antibiotic delivery, offering a potential strategy to mitigate both aseptic loosening and infection risks in arthroplasty.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"375"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0