BMC Research Notes最新文献

{"title":"Designing and implementing a self-learning game with a problem-solving approach to improve students' personal health and healthy nutrition behavior.","authors":"Hossein Ajam Noroozi, Nader Sharifi, Hamid Joveini, Mohammad Hassan Rakhshani, Mansoureh Alipour Anbrani","doi":"10.1186/s13104-025-07244-w","DOIUrl":"10.1186/s13104-025-07244-w","url":null,"abstract":"<p><strong>Objective: </strong>This research is a quasi-experimental study conducted on male students from six elementary schools ranging from third to sixth grade in three regions of Shahrood city from March 2023 to February 2024. This study aimed to designing, implementing and evaluating a health-oriented self-learning game with a problem-solving approach in order to improve behavior in the field of personal health and healthy nutrition in elementary school students.</p><p><strong>Results: </strong>There was a significant difference between the knowledge (p = 0.01), attitude (p > 0.001) and behavior (p = 0.01) in the control and intervention groups, after the intervention, while there was no significant difference between the two groups in these variables before the intervention. The utilization of health-oriented self-learning games proved to be effective in enhancing the knowledge, attitude, and behavior of elementary school students regarding personal health and healthy nutrition.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"212"},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical sensitivity questionnaire for nursing students: psychometric properties of the Persian version.","authors":"Amir Jalali, Azam Sharifi, Behrouz Soltany, Amirhossein Naghibzadeh, Jalal Karimi, Hooman Ghasemi, Parnia Kalhory, Khalil Moradi","doi":"10.1186/s13104-025-07276-2","DOIUrl":"https://doi.org/10.1186/s13104-025-07276-2","url":null,"abstract":"<p><strong>Objective: </strong>Nursing students' ethical sensitivity is crucial for providing high-quality patient care. Assessing this sensitivity using standardized tools is essential for both students and professional nurses. This study aimed to determine the properties of cultural adaptation and the psychometric evaluation of the Ethical Sensitivity Questionnaire for Nursing Students (ESQ-NS).</p><p><strong>Results: </strong>This methodological study, conducted between April and November 2023, involved 480 nursing students who were selected through convenience sampling. The ESQ-NS was translated into Persian following the method described by Wild et al. (2005). The data were analyzed using SPSS (version 27) and LISREL (version 8.8) software. The EFA and CFA validated a three-factor, 13-item structure for the assessment tool. The Pearson correlation coefficient demonstrated a positive and significant correlation between the items and their respective subscales of the overall scale. The reliability of the Persian version of the ESQ-NS was confirmed with a Cronbach's alpha of 0.781, a MacDonald's Omega coefficient of 0.78, and an Intraclass Correlation Coefficient (ICC) of 0.78 (CI: 0.743- 0.816). The Persian version of the ESQ-NS demonstrates acceptable reliability and validity, making it a suitable tool for evaluating the ethical sensitivity of nursing students in Iran.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"209"},"PeriodicalIF":1.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meteorological factors association with under-five children diarrhea incidence in central Gondar zone, Northwest Ethiopia. A time series study.","authors":"Gelila Yitageasu, Hailemariam Feleke, Zewudu Andualem, Lidetu Demoze, Kidist Asrat, Zemichael Gizaw","doi":"10.1186/s13104-025-07270-8","DOIUrl":"https://doi.org/10.1186/s13104-025-07270-8","url":null,"abstract":"<p><strong>Background: </strong>Under 5 children diarrhea has been one of the major public health concerns in countries with limited resources such as Ethiopia. Understanding the association between under-5 diarrhea and meteorological factors will contribute to safeguarding children from adverse health effects through early warning mechanisms. Thus, this study aimed to explore the association between under-5 diarrhea and meteorological factors to reduce health risks.</p><p><strong>Methods: </strong>A time-series ecological study was used to explore the association between meteorological factors and under-5 diarrhea incidence. Spearman's correlation was computed to test the correlation and a negative binomial regression model was fitted to determine the associations of meteorological factors with under-5 diarrhea incidence. The multicollinearity was checked using the variance inflation factor (VIF) before the multivariable regression analysis and the value was 5. aIRRs with 95% CIs and a significance level of 0.05 were used for all the statistical tests. Statistical analyses were conducted using STATA 14.2 software.</p><p><strong>Results: </strong>The highest under-5 diarrhea incidence morbidities was 180.9 per 1000 per year for under-five children. This study revealed a positive and negative correlation between the count of under-5 diarrhea and average monthly temperature and rainfall at 0 and 2 lag months with RRs of 1.0209 (95% CI: 1.0034-1.0387), RR 1.0202(95% CI:1.0022-1.0385), RR 0.999(95% CI:0.9985-0.9996), and RR 0.9992(95% CI:0.9987-0.9997) respectively.</p><p><strong>Conclusion: </strong>There was an association between under 5 diarrhea incidence and meteorological factors in the Central Gondar Zone. The mean monthly temperature and rainfall were positively and negatively related to the incidence of diarrhea in children under 5 years old. The results showed that the observed association between meteorological factors and under-5 diarrhea incidence could be used as evidence for the use of early warning systems for the prevention of childhood diarrhea.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"208"},"PeriodicalIF":1.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are AudioviSual maTERials disseminated via sOcIal meDia effective to improve evidence-based rehabilitation implementation for physiotherapists (ASTEROID trial)? A feasibility study.","authors":"Myllena M G Fernandes, Anna Carolina O Machado, Maurício S Fanfa, Ada C M Silveira, Rafaela A Schreiner, Anna Julia Meireles Dangui, Maitê M Pellenz, Daniela Rigo, Luiza Marx Matte, Emilly Renk Mello, Ane Priscila Diel, Brenda D Guterres, Lucas Dos Santos Costa, Bruna Wageck, Inaihá Laureano Benincá, Carolina Holz Nonnenmacher, Nadine Carneiro Tura, Laura Bortolozzo Leitão, Alessandro Haupenthal, Guilherme S Nunes","doi":"10.1186/s13104-025-07259-3","DOIUrl":"https://doi.org/10.1186/s13104-025-07259-3","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to evaluate the feasibility of an educational program disseminated via social media to improve the scientific and technical knowledge of physiotherapists.</p><p><strong>Results: </strong>In this single-group interventional feasibility study, practicing physiotherapists participated in a 10-week Instagram-based program, which included 20 infographics posted twice weekly. Feasibility was evaluated using the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance). After the intervention, semi-structured interviews were conducted to gather feedback on participant experiences. Of the 30 physiotherapists recruited, 15 initiated the program, and 8 (53%) completed it. No significant differences were observed between pre- and post-program scores on effectiveness outcomes related to perceptions, utilization, and understanding of scientific information for clinical practice. While 63% of participants reported that the program helped them overcome barriers to EBP, overall perceptions and behaviors showed minimal change. Nonetheless, all participants recognized a positive impact on their clinical practice, with 50% reporting that they applied program content to their work. Although 63% indicated they would maintain their approach to studying technical content, all participants affirmed their intention to use resources that facilitate knowledge acquisition. Feedback from interviews indicated positive attitudes towards social media-based educational programs.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"207"},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seedling growth rate and root traits in the maize Nested Association Mapping (NAM) panel.","authors":"Maya Montoya-Pimolwatana, Tai McClellan Maaz, Michael Kantar, Michael Muszynski, Yuriy Mileyko, Rishi Prasadh, Ishwora Dhungana, Kenneth Kiehl, Abigail H Ana, Alanna Nguyen, Alycia Tausaga, Amanda Godfrey, Amanda K Nitta, Bryceson Tugade, D JadenYamagata-Santos, Elizabeth Swantek, Ethan S Morrell, G'Voni Kalaiwaa, Germaine Lindsay Juan, Gunnar Larsen, India Kawelolani Ching, Jesse Mikasobe-Kealiinohomoku, Jessica Araszewski, Joseph Carmelo M Averion, Katie Strachan, Kayla-Marie A Torres, Keara Botanes, Keilah C Wilkes, Lydia Rigge, Malisa Lo, Nicholas Carr, Noa Brenner, Olivia Johnson, Roma Amor B Malasarte, Ruby Noland, Stefano Naldini, Stephenie Andriana Santos, Tomas Pierce, Urban Halpern, Zeus Gean Paul Miguel, Zhuocheng Gan, Nhu H Nguyen","doi":"10.1186/s13104-025-07279-z","DOIUrl":"https://doi.org/10.1186/s13104-025-07279-z","url":null,"abstract":"<p><p>This paper characterizes variation in shoot and root traits collected from the founders of the Maize Nested Association Mapping panel, which was designed to maximize genetic diversity while ensuring appropriate flowering in eastern North America. Here, we present a detailed account of greenhouse experiments conducted by four cohorts of undergraduate research interns at the University of Hawai'i at Mānoa. We summarize data collection, data cleaning procedures, and present data for 38 phenotypic variables for 24 genotypes with the number of plant replicates ranging from 3 to 20. The genotype B73 served as our experimental control to enable comparison over the four years. We also grew a subset of genotypes under different abiotic stress treatments to assess the phenotypic plasticity. These data can be used to predict the potential for different lines to function and capacity to adapt to different environments. Data are published on GitHub repositories, and have large reuse potential by the scientific community, as well as educators of undergraduate and graduate instruction.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"206"},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease.","authors":"Zahra Parker, M Taariq Salie, Kélin Engel, Liesl J Zühlke, Mark E Engel, Timothy F Spracklen","doi":"10.1186/s13104-025-07251-x","DOIUrl":"https://doi.org/10.1186/s13104-025-07251-x","url":null,"abstract":"<p><strong>Objective: </strong>Ficolin-3 is a crucial protein for the activation of the complement system. Previous work has indicated this protein may play a role in the pathogenesis of rheumatic heart disease (RHD), and it has been hypothesised that ficolin-3 has potential as a biomarker for early identification of patients with suspected RHD. This study investigated FCN3 gene polymorphisms rs532781899 (c.349del) and rs4494157 (c.658 + 250 C > A) and ficolin-3 serum concentrations in an ethnically diverse cohort of 53 RHD cases and 45 healthy controls from across Africa.</p><p><strong>Results: </strong>Ficolin-3 was found to be increased by 16% in RHD patients (p = 0.03) compared to controls, but polymorphisms did not associate with the risk of developing RHD nor with ficolin-3 concentrations. Carriers of the c.349del haploinsufficiency locus had normal levels of ficolin-3, while the previously described c.658 + 250 C > A RHD susceptibility locus was found equally in cases and controls. The higher serum ficolin-3 in RHD supports the potential role of this protein in RHD pathogenesis. However, these results suggest that rs532781899 and rs4494157 are not risk factors for the development of RHD in patients from sub-Saharan Africa and would not be reliable as early-stage markers of RHD susceptibility.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"205"},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intronomics-MIP: a snakemake pipeline for analyzing multilocus intron polymorphisms in species identification and population genomics.","authors":"A Scapolatiello, E Boscari, L Schiavon, N Vitulo, L Congiu","doi":"10.1186/s13104-025-07264-6","DOIUrl":"https://doi.org/10.1186/s13104-025-07264-6","url":null,"abstract":"<p><p>In this Research Note, we introduce Intronomics-MIP, a snakemake-based pipeline for the automated analysis of multi-locus intron polymorphisms (MIPs) using intron-targeted amplicon sequencing. Building on established methodologies, our pipeline integrates tools such as Cutadapt, FLASH, and SeekDeep to efficiently process and analyze highly variable intron regions. These MIPs serve as powerful multiple-allelic markers, primarily useful for distinguishing species, identifying cryptic species, disentangling species complexes and detecting hybridization, but can also be informative for assessing population structure without prior species knowledge. Our pipeline enhances reproducibility and scalability, making it adaptable to a wide range of taxa, with a specific demonstration on teleost species. We provide a comprehensive overview of the pipeline's design, along with performance assessments using representative datasets.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"203"},"PeriodicalIF":1.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter's Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study.","authors":"Ekram Mohammed Siraj, Tilahun Bizuayehu Demass, Ayenew Molla Lakew, Lake Yazachew Amogne, Mulat Addis Beshaw","doi":"10.1186/s13104-025-07268-2","DOIUrl":"https://doi.org/10.1186/s13104-025-07268-2","url":null,"abstract":"<p><strong>Objective: </strong>This study was aimed to assess the impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in Alert and St. Peter's Specialized Hospitals, Addis Ababa, Ethiopia.</p><p><strong>Results: </strong>Our study included 344 RR/MDR-TB patients, of which 43.3% were undernourished. The overall unsuccessful treatment outcome was 22.1% (95% CI 0.18, 0.27). Patients with undernutrition were over eight times more likely to develop unsuccessful treatment outcomes [AOR = 8.32 (95% CI 4.48, 15.46)] compared to normal/ overweight individuals. After we computed the binary logistic regression analysis separately for patients with undernutrition and normal/ overweight nutritional status, age, residence, occupation, chest x-ray, anemia, co-morbidities, cigarette smoking, and alcohol drinking were significantly associated with unsuccessful treatment outcomes among undernourished patients, while age, HIV, and smoking were significantly associated with unsuccessful treatment outcomes among patients with normal/overweight individuals.</p><p><strong>Conclusions: </strong>In this study, undernutrition had a remarkable impact on unsuccessful treatment outcomes. Therefore, further researches need to be conducted to integrate the management of undernutrition with the DR-TB treatment program.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"204"},"PeriodicalIF":1.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density.","authors":"Sajad Monjezi, Vahid Soleimani, Maryam Cheraghzadeh, Saeed Ghanbari, Maryam Adelipour","doi":"10.1186/s13104-025-07265-5","DOIUrl":"https://doi.org/10.1186/s13104-025-07265-5","url":null,"abstract":"<p><strong>Objective: </strong>Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD).</p><p><strong>Results: </strong>The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"202"},"PeriodicalIF":1.6,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological analysis of Lassa fever control using novel mathematical modeling and a dual-dosage vaccination approach.","authors":"Akeem Olarewaju Yunus, Morufu Oyedunsi Olayiwola","doi":"10.1186/s13104-025-07218-y","DOIUrl":"https://doi.org/10.1186/s13104-025-07218-y","url":null,"abstract":"<p><p>Lassa fever is a serious health issue in West Africa that requires deeper understanding in order to be effectively controlled. Compared to conventional integer-order methods, this study presents an improved analysis of disease dynamics, including vaccine efficacy, by utilizing fractional-order models and the Laplace Adomian Decomposition methods. This research highlights the critical role of fractional-order dynamics and vaccination impact in understanding Lassa fever transmission and evaluating control strategies. It employs stability and sensitivity analyses, as well as the next-generation matrix method, to assess the basic reproduction number. The study offers novel insights into the importance of expanded vaccination coverage, setting it apart from previous works. The study demonstrated that preventive strategies, particularly double-dose vaccinations, are extremely efficient in controlling Lassa fever and lowering infection rates. It emphasizes the significance of increasing vaccination efforts to safeguard groups that are susceptible. The findings offer important epidemiological insights, boosting efforts to eradicate the disease and improve public health in West Africa and beyond.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"199"},"PeriodicalIF":1.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}