BMC Research Notes最新文献

{"title":"The general health status and its relationship with life skills among service recipients of comprehensive health service centers in Iranian setting: a descriptive-analytical study.","authors":"Yalda Mousazadeh, Parvin Sarbakhsh, Azizollah Arbabisarjou, Mohaddeseh Tolouei, Heydar Mousavi, Esmail Najafi","doi":"10.1186/s13104-025-07201-7","DOIUrl":"10.1186/s13104-025-07201-7","url":null,"abstract":"<p><strong>Objective: </strong>Enhancing a community's health is essential for societal growth and development. Life skills and a healthy lifestyle can improve mental health and overall well-being. This study investigates the relationship between life skills and general health status among service recipients of comprehensive health service centers in Khalkhal County, northwest Iran.</p><p><strong>Results: </strong>A total of 365 participants were included in the study. The mean life skills score was 123.63 (SD = 29.32) and the mean general health score was 30.52 (SD = 15.43). A significant negative correlation was found between life skills and general health (r = -0.55, P < 0.001). Factors such as marital status, age, economic status, type of basic insurance, supplementary insurance, and underlying diseases were identified as predictors of general health. The relationship between life skills and all dimensions of general health was statistically significant (P < 0.001).</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"140"},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and determinants of potentially harmful first aid practices in children with acute poisoning.","authors":"Kavinda Dayasiri","doi":"10.1186/s13104-025-07234-y","DOIUrl":"10.1186/s13104-025-07234-y","url":null,"abstract":"<p><strong>Objective: </strong>To assess the patterns and determinants of harmful first aid practices in children with acute poisoning, and identify factors influencing caregivers' pre-hospital management.</p><p><strong>Results: </strong>This study included 384 children under 12 years, with 29.4% receiving harmful first aid measures. The most common poisoning agents were household chemicals (31.5%), followed by medicines (29.2%). First aid was provided to 29.4% of children, with water and coconut milk being the most common remedies. Harmful first aid was more likely in household chemical poisoning (p = 0.046). Univariate analysis revealed associations between harmful practices and factors such as low maternal education (p = 0.002), remote healthcare access (p = 0.0001), and cultural beliefs (p = 0.003). Multivariate analysis identified remote healthcare access (p = 0.001), low socio-economic status (p = 0.001), low maternal education (p = 0.03), and cultural beliefs (p = 0.05) as significant determinants. Qualitative findings revealed knowledge gaps, financial constraints, and cultural beliefs influencing first aid decisions, highlighting the need for targeted interventions.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"141"},"PeriodicalIF":1.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De Novo transcriptome assembly and annotation of the wild service tree Sorbus torminalis (L.) Crantz.","authors":"Sara Pinosio, Camilla Avanzi, Francesca Bagnoli, Ilaria Spanu, Giovanni Giuseppe Vendramin, Andrea Piotti","doi":"10.1186/s13104-025-07163-w","DOIUrl":"10.1186/s13104-025-07163-w","url":null,"abstract":"<p><strong>Objectives: </strong>The wild service tree, Sorbus torminalis (L.) Crantz, is a sub-Mediterranean forest tree species native to Europe, Asia Minor, Caucasus and north-western Africa. Despite its ecological and societal importance, publicly available molecular resources for this species are scarce, limited to the chloroplast genome. Within the European Project FORGENIUS (Improving access to FORest GENetic resources Information and services for end-Users, Grant Agreement ID: 862221) we assembled the transcriptome of the wild service tree with the aim to use it as reference to develop new genetic markers and perform a large-scale population genetics study in this species.</p><p><strong>Data description: </strong>An RNA-seq library was generated from pooled RNA extracted from four different tissues (young leaves, mature leaves, stems and roots) of a single S. torminalis sapling and sequenced on the Illumina HiSeq 2500 platform. This dataset was used to produce and annotate the first transcriptome assembly for S. torminalis, paving the way for future genomic research and applications in this species. For example, this study will facilitate the development of molecular markers such as SSRs and SNPs, useful for genetic studies, breeding programs, and conservation efforts and will serve as a reference for future differential expression studies, providing a deeper understanding of the species' biology.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"139"},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-rater disagreement in manual scoring of intensive care unit sleep data.","authors":"Laurens Reinke, Esther M van der Heide, Pedro Fonseca, Anthony R Absalom, Jaap E Tulleken","doi":"10.1186/s13104-025-07198-z","DOIUrl":"10.1186/s13104-025-07198-z","url":null,"abstract":"<p><strong>Objective: </strong>Severe sleep disruption is common among intensive care unit (ICU) patients. However, the applicability of standard sleep scoring guidelines by the American Academy of Sleep Medicine (AASM) has been questioned, with most polysomnography (PSG) studies in critically ill patients reporting difficulties in setting up and processing and scoring the recordings. The present study explores human inter-rater agreement in sleep stage scoring following the AASM guidelines, within a heterogenous ICU patient cohort.</p><p><strong>Results: </strong>Two human experts independently scored a total of 51,454 epochs in 20 PSG recordings acquired at the ICU. Epoch-per-epoch comparison of scored stages revealed a Cohen's κ coefficient of agreement of 0.36 for standard 5-stage scoring. Highest agreement occurred in Wake (κ = 0.46), while REM showed the lowest (κ = 0.12). Significant correlations were found between inter-rater agreement, and Simplified Acute Physiology Score (SAPS II, r = - 0.506, p = 0.038), and 12-month mortality (r = - 0.524, p = 0.031). Comparison with similar studies underscore challenges in applying AASM criteria to ICU patients. Despite accounting for artifacts, disparities persisted, emphasizing the need for a nuanced exploration of factors influencing scoring inconsistencies in critically ill patients.</p><p><strong>Trial registration: </strong>Trial was registered as \"Sleep and biorhythm in the ICU\", in the Centrale Commissie Mensgebonden Onderzoek register, with number NL-OMON43659 ( https://onderzoekmetmensen.nl/nl/trial/43659 ), on registration date august 4th 2015.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"138"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling of childbearing progression among women living with HIV in Ibadan, Nigeria.","authors":"Ahmed Olagunju, Joshua O Akinyemi, Rotimi Afolabi, Olutosin A Awolude","doi":"10.1186/s13104-025-07193-4","DOIUrl":"10.1186/s13104-025-07193-4","url":null,"abstract":"<p><strong>Background: </strong>Childbearing is a major concern for women living with HIV especially in low-middle income countries. There are fears about access to care, risk of vertical transmission, health challenges, maternal and child morbidity/mortality. Investigation of childbearing progression and its associated factors among these women will be useful for design of reproductive healthcare services of these women and ultimately address their multifaceted concerns. This study examined childbearing progression and its correlates another among women living with HIV in Ibadan.</p><p><strong>Method: </strong>The study used a dataset from a cross-sectional study on childbearing progression among 933 respondents aged (18-49) receiving HIV care at the University College Hospital, Ibadan. Synthetic Relational Gompertz method was used to estimate fertility rate in the study population while a multistate model was developed to identify the factors associated with progression from one birth to the next.</p><p><strong>Results: </strong>The average age of participants was 38 years, with majority being Yoruba tribe (80.5%). Nearly all had at least basic education (93%), and about half had 1-2 children at the time of their HIV diagnosis (47.6%). The likelihood of progressing from the first to a second birth was 77%, though no specific factors were statistically significant. However, progression to a third birth was significantly less likely (86% lower), and associated with factors such as: Having 1-2 children at HIV diagnosis (59% less likely to progress). Having more than 2 children at HIV diagnosis (94% more likely to progress), marital status (widowed women were 36% more likely to progress), partner's education (secondary education increased the likelihood by 23%), partner's employment status (unemployed partners increased the likelihood by 40%), desire for more children, partner's HIV-negative status. Progression to fourth and subsequent births showed a continued decline, with the likelihood of a fourth birth being 82% lower and a fifth or sixth birth 85% lower. Women with secondary education were significantly less likely to progress to fifth births.</p><p><strong>Conclusion: </strong>Overall, the corrected total fertility rate is 3.54, it's below the national estimates and Southwest region which implies fertility is declining among women living with HIV in Ibadan. The findings revealed the relevance of socio-economic and demographic factors in childbearing progression among women living with HIV. Focused interventions should aim to provide better family planning support and integrate reproductive health counseling into HIV care programs.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"137"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of association of the calpain-10 Indel-19 variant with chronic diseases in a Mexican population.","authors":"Juan Pablo Meza-Espinoza, Juan de Dios Zavala-Rubio, Evelia Leal-Ugarte, Verónica Judith Picos-Cárdenas, José Alfredo Contreras-Gutiérrez, Jesús Madueña-Molina, Josué Camberos-Barraza, Salvador Cervín-Serrano, María Lourdes Varela Germán","doi":"10.1186/s13104-025-07184-5","DOIUrl":"10.1186/s13104-025-07184-5","url":null,"abstract":"<p><strong>Objective: </strong>The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic disorders, mainly obesity. This study aimed to investigate the association between the CAPN10 Indel-19 variant and some clinical parameters in a Mexican population sample. We recruited 426 apparently healthy individuals over 30 years of age. We obtained anthropometric data, arterial pressure, fasting biochemical parameters, and genotyping for CAPN10 Indel-19.</p><p><strong>Results: </strong>The frequency of overweight and obesity was 82.9%, hypertension 8%, hypercholesterolemia 14.8%, hypertriglyceridemia 31.9%, impaired plasma glucose 23.9%, and diabetes 4.7%. The genotype frequencies were 13.1%, 47.9%, and 39% for del/del, del/ins, and ins/ins, respectively; the allele frequencies were 37.1% for the del allele and 62.9% for the ins allele. The analysis of the continuous parameters according to the genotypes showed no significant differences. However, when these parameters were dichotomized (reference group versus high-level group), the ins allele was associated with a protective effect against high arterial pressure (prehypertension and hypertension). It is unclear whether the CAPN10 Indel-19 variant increases the risk of chronic diseases, so further studies are needed to confirm or refute this issue.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"135"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer brain metastasis: evaluating the effectiveness of alginate-based organoids in metastasis modeling to replace matrigel.","authors":"Sepehr Zamani, Fateme Sadat Bitaraf, Mohammad Kamalabadi-Farahani","doi":"10.1186/s13104-025-07154-x","DOIUrl":"10.1186/s13104-025-07154-x","url":null,"abstract":"<p><strong>Background: </strong>One of the most important and devastating side effects of breast cancer is brain metastasis. Our understanding of cancer heterogeneity is revolutionized by tumoral organoids and seems promising for personalized medicine. This study aimed to generate a hydrogel-based brain metastasis organoid.</p><p><strong>Methods: </strong>Mouse brain metastatic tumor cells (4T1B) were isolated and cultured from the brain metastasis lesions of mice with breast cancer. Different hydrogels, including alginate, carboxymethylcellulose, gelatin, collagen, and matrigel, were prepared. Pre-coated hydrogels in 96-well plates were treated with 4T1B cells. The morphology and viability of metastatic organoids were analyzed after 7 days.</p><p><strong>Results: </strong>According to our results, 4T1B cells formed semi-regular cluster structures in alginate hydrogel. In this group, the cell survival rate and formation of three-dimensional structures were significantly higher than in other groups.</p><p><strong>Conclusion: </strong>For organoid cultures, there's a lot of research on natural and synthetic scaffolds that are chemically or mechanically well-designed. In the present study, we used highly brain metastatic tumor cells and detected that alginate hydrogel is the best choice for organoid formation and breast cancer brain metastasis modeling.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"134"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of preservative and preservation methods on physical, chemical and microbiological properties of nipa palm (Nypa fructicans) sap.","authors":"Dayang Nur Athirah, Mohd Razip Asaruddin, Showkat Ahmad Bhawani, Aldrin Felix Simbas, Kho Swen Jack","doi":"10.1186/s13104-024-07039-5","DOIUrl":"10.1186/s13104-024-07039-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the effectiveness of the E' food grade preservative - potassium sorbate (E202) and sodium metabisulfite (E223) in an aqueous form, and impact of the timing of preservative addition on the shelf-life, sugar and reducing sugars levels, organic acids content and microbial growth of nipa palm sap.</p><p><strong>Results: </strong>The pH, sugar and reducing sugars levels, organic acids content, total bacterial count (TBC) and sensory characteristics of the sample were determined. The results showed that the treated samples were able to slow down the pH and sucrose content from dropping during storage. Sample A had lactic acid at 0.93 ± 0.01 g/L and acetic acid at 0.05 ± 0.0.1 g/L, while Sample B had 0.97 ± 0.02 g/L and 0.07 ± 0.01 g/L, respectively, both lower than the control (1.10 ± 0.01 g/L and 0.09 ± 0.02 g/L). Sample A with TBC of 1.03 (± 0.08) x 10⁵ CFU/mL was able to inhibit microbial growth better than Sample B, 1.14 (± 0.13) x 10⁵ CFU/mL. Preservative application prior to tapping was shown to be more successful in preserving the quality and shelf-life of nipa palm sap. This approach is likely preventing early microbial activity and fermentation without the need of proper packaging, preserving the freshness and quality of the sap more effectively than adding the preservative after collection.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"136"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of influenza A of pandemic potential and MERS-Coronavirus in humans in Cameroon.","authors":"Chavely Gwladys Monamele, Ripa Mohamadou Njankouo, Christian Nsangou Yogne, Loique Landry Messanga Essengue, Chanceline Ndongo Bilounga, Desmon Toutou Tsafack, Hermann Landry Munshili Njifon, Ubald Tamoufe, Ronald Perraut, Richard Njouom","doi":"10.1186/s13104-025-07179-2","DOIUrl":"10.1186/s13104-025-07179-2","url":null,"abstract":"<p><strong>Objective: </strong>According to the World Health Organization, surveillance for respiratory viruses with pandemic potential should be included in routine surveillance to be on alert for zoonotic transmission. This study reports on data from the surveillance of influenza A/H5, influenza A/H7 and MERS-Coronavirus in Cameroon.</p><p><strong>Results: </strong>A total of 855 participants were enrolled. Of these, 11.7% were positive for influenza A and none were positive for influenza A/H5, A/H7 and MERS-Coronavirus. Most participants (77.1%) were enrolled within 5 days of illness onset and the younger population under 2 years of age (31.4%) was the most represented. In terms of clinical manifestations, the majority had flu-like symptoms including fever, cough, rhinorrhoea, asthenia, shortness of breath, noisy breathing and headache. These results are important to fill the knowledge gap on the epidemiology of influenza A/H5, A/H7 and MERS-Coronavirus in humans, for which information is lacking in several countries.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"133"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the variability of temperature on the population dynamics of Anopheles arabiensis.","authors":"Ademe Kebede Gizaw, Temesgen Erena, Eba Alemayehu Simma, Dawit Kechine Menbiko, Dinka Tilahun Etefa, Delenasaw Yewhalaw, Chernet Tuge Deressa","doi":"10.1186/s13104-025-07153-y","DOIUrl":"10.1186/s13104-025-07153-y","url":null,"abstract":"<p><p>Mosquitoes, notorious vectors of numerous diseases transmitted through bites, pose a significant public health threat, particularly in tropical and subtropical regions. Climate change may affect the risk of mosquito-borne diseases. This study investigated how temperature affects the population dynamics of all stages of Anopheles arabiensis mosquitoes, including eggs, larvae, pupae, and adults. We developed and analyzed a mathematical model that incorporates logistic growth and temperature. The well-posedness of the proposed model was proved. We demonstrated that if the non-autonomous basic reproduction number is less than unity, the disease-free equilibrium is locally asymptotically stable. Conversely, if it is greater than unity, there exists at least one positive periodic solution, as established by applying the comparison theorem and the theory of uniform persistence. Furthermore, the model parameters were fitted to real-world data conducted in the Tropical and Infectious Diseases Research Center (TIDRC) in Sekoru, Jimma University. The model presents the population dynamics of both immature and adult An. Arabiensis, which is similar to the observed experimental data obtained from TIDRC. Therefore, our model suggests that using the results obtained, it can be used to predict the impact of various intervention strategies on An. arabiensis distribution.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"132"},"PeriodicalIF":1.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}