Brain Stimulation最新文献

{"title":"Transcranial magnetic stimulation improves language and language network functional connectivity in a patient with logopenic primary progressive aphasia","authors":"Alexandra Touroutoglou , Yuta Katsumi , Neguine Rezaii, Thiago Paranhos, Amelia Jones, Daisy Hochberg, Megan Quimby, Shalom K. Henderson, Bonnie Wong, Michael Brickhouse, Joan A. Camprodon, Bradford C. Dickerson , Mark C. Eldaief","doi":"10.1016/j.brs.2024.10.002","DOIUrl":"10.1016/j.brs.2024.10.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1213-1215"},"PeriodicalIF":7.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of theta-gamma tACS on motor skill acquisition in young individuals and stroke survivors: A double-blind, randomized, sham-controlled study","authors":"L.S. Grigutsch ,&nbsp;B. Haverland ,&nbsp;L.S. Timmsen ,&nbsp;L. Asmussen ,&nbsp;H. Braaß ,&nbsp;S. Wolf ,&nbsp;T.V. Luu ,&nbsp;C.J. Stagg ,&nbsp;R. Schulz ,&nbsp;F. Quandt ,&nbsp;B.C. Schwab","doi":"10.1016/j.brs.2024.09.001","DOIUrl":"10.1016/j.brs.2024.09.001","url":null,"abstract":"<div><h3>Background</h3><p>Theta-gamma transcranial alternating current stimulation (tACS) was recently found to enhance thumb acceleration in young, healthy participants, suggesting a potential role in facilitating motor skill acquisition. Given the relevance of motor skill acquisition in stroke rehabilitation, theta-gamma tACS may hold potential for treating stroke survivors.</p></div><div><h3>Objective</h3><p>We aimed to examine the effects of theta-gamma tACS on motor skill acquisition in young, healthy participants and stroke survivors.</p></div><div><h3>Methods</h3><p>In a pre-registered, double-blind, randomized, sham-controlled study, 78 young, healthy participants received either theta-gamma peak-coupled (TGP) tACS, theta-gamma trough-coupled (TGT) tACS or sham stimulation. 20 individuals with a chronic stroke received either TGP or sham. TACS was applied over motor cortical areas while participants performed an acceleration-dependent thumb movement task. Stroke survivors were characterized using standardized testing, with a subgroup receiving additional structural brain imaging.</p></div><div><h3>Results</h3><p>Neither TGP nor TGT tACS significantly modified general motor skill acquisition in the young, healthy cohort. In contrast, in the stroke cohort, TGP diminished motor skill acquisition compared to sham. Exploratory analyses revealed that, independent of general motor skill acquisition, healthy participants receiving TGP or TGT exhibited greater peak thumb acceleration than those receiving sham.</p></div><div><h3>Conclusion</h3><p>Although theta-gamma tACS increased thumb acceleration in young, healthy participants, consistent with previous reports, it did not enhance overall motor skill acquisition in a more complex motor task. Furthermore, it even had detrimental effects on motor skill acquisition in stroke survivors.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1076-1085"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001554/pdfft?md5=44af66a15652499afccf0ce4f7f5d9e5&pid=1-s2.0-S1935861X24001554-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidural magnetic stimulation of the motor cortex using an implantable coil","authors":"Kyeong Jae Lee ,&nbsp;Jae-Won Jang ,&nbsp;June Sic Kim ,&nbsp;Sohee Kim","doi":"10.1016/j.brs.2024.10.001","DOIUrl":"10.1016/j.brs.2024.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Magnetic stimulation, represented by transcranial magnetic stimulation (TMS), is used to treat neurological diseases. Various strategies have been explored to improve the spatial resolution of magnetic stimulation. While reducing the coil size is the most impactful approach for increasing the spatial resolution, it decreases the stimulation intensity and increases heat generation.</div></div><div><h3>Objective</h3><div>We aim to demonstrate the feasibility of magnetic stimulation using an epidurally implanted millimeter-sized coil and that it does not damage the cortical tissue via heating even when a repetitive stimulation protocol is used.</div></div><div><h3>Methods</h3><div>A coil with dimensions of 3.5 × 3.5 × 2.6 mm³ was epidurally implanted on the left motor cortex of rat, corresponding to the right hindlimb. Before and after epidural magnetic stimulation using a quadripulse stimulation (QPS) protocol, changes in the amplitude of motor evoked potentials (MEPs) elicited by a TMS coil were compared.</div></div><div><h3>Results</h3><div>The experimental group showed an average increase of 88 % in MEP amplitude in the right hindlimb after QPS, whereas the MEP amplitude in the left hindlimb increased by 18 % on average. The control group showed no significant change in MEP amplitude after QPS in either hindlimb. The temperature changes at the coil surface remained &lt;2 °C during repetitive stimulation, meeting the thermal safety limit for implantable medical devices.</div></div><div><h3>Conclusion</h3><div>These results demonstrate the feasibility of epidural magnetic stimulation using an implantable coil to induce neuromodulation effects. This novel method is expected to be a promising alternative for focal magnetic stimulation with an improved spatial resolution and lowered stimulus current than previous magnetic stimulation methods.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1157-1166"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling action potentials with magnetoelectric nanoparticles","authors":"Elric Zhang ,&nbsp;Max Shotbolt ,&nbsp;Chen-Yu Chang ,&nbsp;Aidan Scott-Vandeusen ,&nbsp;Shawnus Chen ,&nbsp;Ping Liang ,&nbsp;Daniela Radu ,&nbsp;Sakhrat Khizroev","doi":"10.1016/j.brs.2024.08.008","DOIUrl":"10.1016/j.brs.2024.08.008","url":null,"abstract":"&lt;div&gt;&lt;p&gt;Non-invasive or minutely invasive and wireless brain stimulation that can target any region of the brain is an open problem in engineering and neuroscience with serious implications for the treatment of numerous neurological diseases. Despite significant recent progress in advancing new methods of neuromodulation, none has successfully replicated the efficacy of traditional wired stimulation and improved on its downsides without introducing new complications. Due to the capability to convert magnetic fields into local electric fields, MagnetoElectric NanoParticle (MENP) neuromodulation is a recently proposed framework based on new materials that can locally sensitize neurons to specific, low-strength alternating current (AC) magnetic fields (50Hz 1.7 kOe field). However, the current research into this neuromodulation concept is at a very early stage, and the theoretically feasible game-changing advantages remain to be proven experimentally. To break this stalemate phase, this study leveraged understanding of the non-linear properties of MENPs and the nanoparticles' field interaction with the cellular microenvironment. Particularly, the applied magnetic field's strength and frequency were tailored to the M − H hysteresis loop of the nanoparticles. Furthermore, rectangular prisms instead of the more traditional “spherical” nanoparticle shapes were used to: (i) maximize the magnetoelectric effect and (ii) improve the nanoparticle-cell-membrane surface interface. Neuromodulation performance was evaluated in a series of exploratory in vitro experiments on 2446 rat hippocampus neurons. Linear mixed effect models were used to ensure the independence of samples by accounting for fixed adjacency effects in synchronized firing. Neural activity was measured over repeated 4-min segments, containing 90 s of baseline measurements, 90 s of stimulation measurements, and 60 s of post stimulation measurements. 87.5 % of stimulation attempts produced statistically significant (P &lt; 0.05) changes in neural activity, with 58.3 % producing large changes (P &lt; 0.01). In negative controls using either zero or 1.7 kOe-strength field without nanoparticles, no experiments produced significant changes in neural activity (P &gt; 0.05 and P &gt; 0.15 respectively). Furthermore, an exploratory analysis of a direct current (DC) magnetic field indicated that the DC field could be used with MENPs to inhibit neuron activity (P &lt; 0.01). These experiments demonstrated the potential for magnetoelectric neuromodulation to offer a near one-to-one functionality match with conventional electrode stimulation without requiring surgical intervention or genetic modification to achieve success, instead relying on physical properties of these nanoparticles as “On/Off” control mechanisms.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;One-sentence summary&lt;/h3&gt;&lt;p&gt;This in vitro neural cell culture study explores how to exploit the non-linear and anisotropic properties of magnetoelectric nanoparticles for wirel","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1005-1017"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001499/pdfft?md5=cd88f13ce2ebb019e822e9ae8e7047d9&pid=1-s2.0-S1935861X24001499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused magnetic stimulation for motor recovery after stroke","authors":"Ja-Hae Kim ,&nbsp;Minhee Jeong ,&nbsp;Hohyeon Kim ,&nbsp;Ji-Hye Kim ,&nbsp;Ji Woong Ahn ,&nbsp;Boyoung Son ,&nbsp;Kang-Ho Choi ,&nbsp;Seungsoo Chung ,&nbsp;Jungwon Yoon","doi":"10.1016/j.brs.2024.08.011","DOIUrl":"10.1016/j.brs.2024.08.011","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The effects of noninvasive focused magnetothermal brain stimulation using magnetic nanoparticles (MNPs) on post-stroke motor deficits and metabolic dormancy in subacute ischemic injury are not well-established. This study examined if magnetothermal brain stimulation using magnetic nanoparticles (Nano-MS) enhances motor recovery after stroke.</p></div><div><h3>Methods</h3><p>We randomly distributed rats into Sham, Control, MNP injection only, and Nano-MS groups. We administered focused magnetic stimulation for 30 min daily following an MNP injection (15 mg/mL) into the targeted motor cortex via the carotid artery three weeks after the transient (90 min) middle cerebral artery occlusion. We assessed motor functionality via behavioral tests and conducted positron emission tomography (PET) imaging to verify cerebral metabolic activity. We assessed neuronal excitability, neuroinflammation, blood-brain barrier (BBB) integrity, and neurogenesis four weeks post-stroke.</p></div><div><h3>Results</h3><p>The Nano-MS group exhibited significantly improved motor deficits and cerebral metabolic activity compared to the Control and MNP groups (<em>p</em> &lt; 0.05). Focused Nano-MS modulated neuronal excitability, evident by a depolarized action potential threshold for spike initiation and reduced firing frequency post-stroke. The Nano-MS group demonstrated markedly decreased inflammatory markers, such as IL-1β, IL-6, TNF-α, MCP-1, and ICAM-1, compared to the Control and MNP groups. BBB integrity and immunofluorescence for neurogenesis markers were substantially improved in the Nano-MS group.</p></div><div><h3>Conclusions</h3><p>Focused Nano-MS facilitates the recovery of motor deficits and metabolic inactivity in the brain by effectively modulating excitability, reducing neuroinflammation, enhancing BBB stability, and promoting neurogenesis. Nano-MS is a potential novel, noninvasive therapy for stroke rehabilitation. Further investigation is warranted.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1048-1059"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001529/pdfft?md5=d2028cb91901cf1cee4cd35e4d6711b1&pid=1-s2.0-S1935861X24001529-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial focused ultrasound stimulation enhances cerebrospinal fluid movement: Real-time in vivo two-photon and widefield imaging evidence","authors":"Seunghwan Choi ,&nbsp;Jeungeun Kum ,&nbsp;Seon Young Hyun ,&nbsp;Tae Young Park ,&nbsp;Hyungmin Kim ,&nbsp;Sun Kwang Kim ,&nbsp;Jaeho Kim","doi":"10.1016/j.brs.2024.09.006","DOIUrl":"10.1016/j.brs.2024.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Cerebrospinal fluid (CSF) flow is crucial for brain homeostasis and its dysfunction is highly associated with neurodegenerative diseases. Restoring CSF circulation is proposed as a key strategy for the treatment of the diseases. Among the methods to improve CSF circulation, focused ultrasound (FUS) stimulation has emerged as a promising non-invasive brain stimulation technique, with effectiveness evidenced by <em>ex vivo</em> studies. However, due to technical disturbances in <em>in vivo</em> imaging combined with FUS, direct evidence of real-time <em>in vivo</em> CSF flow enhancement by FUS remains elusive.</p></div><div><h3>Objective</h3><p>To investigate whether FUS administered through the skull base can enhance CSF influx in living animals with various real-time imaging techniques.</p></div><div><h3>Methods</h3><p>We demonstrate a novel method of applying FUS through the skull base, facilitating cortical CSF influx, evidenced by diverse <em>in vivo</em> imaging techniques. Acoustic simulation confirmed effective sonication of our approach through the skull base. After injecting fluorescent CSF tracers into cisterna magna, FUS was administered at the midline of the jaw through the skull base for 30 min, during which imaging was performed concurrently.</p></div><div><h3>Results</h3><p>Enhanced CSF influx was observed in macroscopic imaging, demonstrated by the influx area and intensity of the fluorescent dyes after FUS. In two-photon imaging, increased fluorescence was observed in the perivascular space (PVS) after stimulation. Moreover, particle tracking of microspheres showed more microspheres entering the imaging field, with increased mean speed after FUS.</p></div><div><h3>Conclusion</h3><p>Our findings provide direct real-time <em>in vivo</em> imaging evidence that FUS promotes CSF influx and flow in the PVS.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1119-1130"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001591/pdfft?md5=f6d68ddbe0c81b92aa048d3ed7c57acf&pid=1-s2.0-S1935861X24001591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial magnetic stimulation-associated heart rate decelerations attenuate after a TMS treatment course for depression","authors":"Alexandra A. Alario,&nbsp;Benjamin D. Pace,&nbsp;Mark J. Niciu,&nbsp;Nicholas T. Trapp","doi":"10.1016/j.brs.2024.09.011","DOIUrl":"10.1016/j.brs.2024.09.011","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1155-1156"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of subject motion during TMS via pulsewise coil displacement","authors":"Ole Numssen,&nbsp;Sandra Martin,&nbsp;Kathleen Williams,&nbsp;Thomas R. Knösche ,&nbsp;Gesa Hartwigsen","doi":"10.1016/j.brs.2024.08.009","DOIUrl":"10.1016/j.brs.2024.08.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1045-1047"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001505/pdfft?md5=b99823776f8ca9c81772c1e2e0cbc079&pid=1-s2.0-S1935861X24001505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive closed-loop modulation of cortical theta oscillations: Insights into the neural dynamics of navigational decision-making","authors":"Farhad Farkhondeh Tale Navi ,&nbsp;Soomaayeh Heysieattalab ,&nbsp;Mohammad Reza Raoufy ,&nbsp;Saied Sabaghypour ,&nbsp;Milad Nazari ,&nbsp;Mohammad Ali Nazari","doi":"10.1016/j.brs.2024.09.005","DOIUrl":"10.1016/j.brs.2024.09.005","url":null,"abstract":"<div><p>Navigational decision-making tasks, such as spatial working memory (SWM), rely highly on information integration from several cortical and sub-cortical regions. Performance in SWM tasks is associated with theta rhythm, including low-frequency oscillations related to movement and memory. The interaction of the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC), reflected in theta synchrony, is essential in various steps of information processing during SWM. We used a closed-loop neurofeedback (CLNF) system to upregulate theta power in the mPFC and investigate its effects on circuit dynamics and behavior in animal models. Specifically, we hypothesized that enhancing the power of the theta rhythm in the mPFC might improve SWM performance. Animals were divided into three groups: closed-loop (CL), random-loop (RL), and OFF (without stimulation). We recorded local field potential (LFP) in the mPFC while electrical reward stimulation contingent on cortical theta activity was delivered to the lateral hypothalamus (LH), which is considered one of the central reward-associated regions. We also recorded LFP in the vHPC to evaluate the related subcortical neural changes. Results revealed a sustained increase in the theta power in both mPFC and vHPC for the CL group. Our analysis also revealed an increase in mPFC-vHPC synchronization in the theta range over the stimulation sessions in the CL group, as measured by coherence and cross-correlation in the theta frequency band. The reinforcement of this circuit improved spatial decision-making performance in the subsequent behavioral results. Our findings provide direct evidence of the relationship between specific theta upregulation and SWM performance and suggest that theta oscillations are integral to cognitive processes. Overall, this study highlights the potential of adaptive CLNF systems in investigating neural dynamics in various brain circuits.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1101-1118"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001608/pdfft?md5=e6e386dcb782540ba3a796c365e4d0ff&pid=1-s2.0-S1935861X24001608-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events with concurrent cannabis use during transcranial magnetic stimulation therapy for major depressive disorder: A case series analysis","authors":"Gian M. DePamphilis,&nbsp;Eric Tirrell,&nbsp;E. Frances Kronenberg,&nbsp;Joshua C. Brown,&nbsp;Andrew M. Fukuda,&nbsp;Linda L. Carpenter","doi":"10.1016/j.brs.2024.09.008","DOIUrl":"10.1016/j.brs.2024.09.008","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1140-1141"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001633/pdfft?md5=b2f9c77ff9b9651345e73fdfafef0420&pid=1-s2.0-S1935861X24001633-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}