Brain Stimulation最新文献

{"title":"Turning up the current – optimizing stimulation parameters with vagus nerve stimulation in a nationwide Norwegian cohort (The NOR-current study)","authors":"Konstantin Hrisimirov Kostov ,&nbsp;Hrisimir Kostov ,&nbsp;Pål Gunnar Larsson ,&nbsp;Oliver Henning ,&nbsp;Arild Egge ,&nbsp;Morten Ingvar Lossius ,&nbsp;Jukka Peltola","doi":"10.1016/j.brs.2025.06.016","DOIUrl":"10.1016/j.brs.2025.06.016","url":null,"abstract":"<div><h3>Background</h3><div>Despite widespread use of vagus nerve stimulation (VNS), evidence regarding optimal stimulation titration and dosing remains limited. Significant inter-practice variability and deviation from guidelines, results in sub-optimal dosing.</div></div><div><h3>Objective</h3><div>Identify optimal stimulation parameters and establish target dosing for VNS therapy in epilepsy.</div></div><div><h3>Methods</h3><div>We linked long-term outcomes with dosing parameters in 415 patients from a VNS registry (median follow-up = 79.0 months). A generalized linear mixed model (GLMM) assessed relationships between stimulation parameters (Output Current (OC), Frequency, Pulse Width (PW), Duty cycle [DC]) and very good clinical response (≥75 % seizure frequency reduction from baseline).</div></div><div><h3>Results</h3><div>Output current was the strongest predictor of seizure reduction (p = 0.001). Increasing OC by 1 mA more than doubled the probability of ≥75 % seizure reduction, peaking at 2.70 mA. Greatest likelihood of ≥50 % seizure reduction was at 2.1 mA. Post-hoc analysis supported GLMM findings, showing significantly more patients (46.3 %) receiving &gt;2.0 mA OC achieved ≥75 % seizure reduction compared with 30.7 % (p = 0.01) among patients using lower OC. Although changes in DC were not significantly associated with seizure reduction, post-hoc analysis suggested benefits from other duty cycles. Standard 250 μs PW and 20 Hz frequency were associated with best effect. Longer follow-up improved seizure control (p &lt; 0.001); intellectual disability negatively impacted response (p = 0.005). Seizure-free patients had significantly lower total charge (122.4 vs. 250.1 mC, p = 0.014) than patients with persistent seizures.</div></div><div><h3>Conclusion</h3><div>Output current should be the primary focus when titrating VNS patients to optimal dose. We suggest a target range of 1.5–2.25 mA with 250 μs PW and 20 Hz frequency. Higher OC should be attempted if tolerated.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1212-1219"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Protective effects of Electroacupuncture on patients with spontaneous severe intraventricular hemorrhage” [Brain Stimul 18 (1) (2025) 606]","authors":"Wusi Qiu ,&nbsp;Mingmin Chen ,&nbsp;Lihong Fu","doi":"10.1016/j.brs.2025.05.124","DOIUrl":"10.1016/j.brs.2025.05.124","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1248"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased variability in response to transcranial direct current stimulation in healthy older compared to young adults: A systematic review and meta-analysis","authors":"Anna Elisabeth Fromm ,&nbsp;Catalina Trujillo-Llano ,&nbsp;Ulrike Grittner ,&nbsp;Marcus Meinzer ,&nbsp;Agnes Flöel ,&nbsp;Daria Antonenko","doi":"10.1016/j.brs.2025.06.005","DOIUrl":"10.1016/j.brs.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>Healthy aging is associated with a decline in cognitive and motor functions, affecting daily activities and quality of life. Combining transcranial direct current stimulation (tDCS) with behavioral training may be a promising intervention against this decline. However, individual response variability may obscure group-level effects and mislead conclusions about tDCS efficacy. Quantifying this variability is crucial for accurately assessing stimulation effects and understanding individual response factors, like age. Yet, no study has quantitatively compared tDCS variability across age groups. This systematic review and meta-analysis examine age-related variability in cognitive and motor responses to tDCS.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we searched PubMed and Cochrane for studies directly comparing young and healthy older adults under similar experimental conditions. Across 19 studies comprising 390 older adults (mean ± SD age: 67 ± 5 years) and 384 young adults (mean ± SD age: 24 ± 3 years) receiving transcranial direct current (tDCS), we quantified behavioral variability using the log-transformed coefficient of variation ratio (lnCVR).</div></div><div><h3>Results</h3><div>Results revealed substantially higher response variability in healthy older compared to young adults during active tES (21 %, lnCVR_active = −0.24 [-0.43, −0.04], p = 0.02), but not during sham conditions (lnCVR_sham = −0.18 [-0.42, 0.05], p = 0.13).</div></div><div><h3>Conclusion</h3><div>These findings provide the first quantitative evidence that advanced age increases behavioral tDCS response variability, highlighting the need to develop personalized tDCS approaches to optimize their efficacy in older populations.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1257-1265"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Reward processing and prediction errors in frontal and basal ganglia signals during decision making” [Brain Stimul 18 (1) (2025) 234]","authors":"Colin Hoy ,&nbsp;Wouter Kool ,&nbsp;Philip Starr ,&nbsp;Simon Little","doi":"10.1016/j.brs.2025.05.131","DOIUrl":"10.1016/j.brs.2025.05.131","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1250"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Magnetoelectric film for wireless low-frequency’ [Brain Stimul 18 (1) (2025) 284]","authors":"Asli Aydin ,&nbsp;Ali Jahanshahi ,&nbsp;Pouria Esmaeili-Dokht ,&nbsp;Mertcan Han ,&nbsp;Gaurav Gardi ,&nbsp;Yasin Temel ,&nbsp;Metin Sitti","doi":"10.1016/j.brs.2025.05.106","DOIUrl":"10.1016/j.brs.2025.05.106","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1241"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Evoked resonant neural activity to guide deep brain stimulation for movement disorders” [Brain Stimulation 18(1) (2025) 286]","authors":"Kara Johnson","doi":"10.1016/j.brs.2025.05.123","DOIUrl":"10.1016/j.brs.2025.05.123","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1237"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Development and in silico validation of innovative technological approaches to improve vagus nerve stimulation protocols” [Brain Stimul 18 (1) (2025) 237]","authors":"Alice Giannotti ,&nbsp;Claudio Verardo ,&nbsp;Angela Braccia ,&nbsp;Outman Akouissi ,&nbsp;Ciro Zinno ,&nbsp;Eugenio Redolfi Riva ,&nbsp;Simone Romeni ,&nbsp;Stephanie Lacour ,&nbsp;Silvestro Micera","doi":"10.1016/j.brs.2025.05.117","DOIUrl":"10.1016/j.brs.2025.05.117","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1251"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-type-specific responses to single-pulse electrical stimulation of the human brain","authors":"Rhiannon L. Cowan ,&nbsp;Tyler S. Davis ,&nbsp;Edward M. Merricks ,&nbsp;Bornali Kundu ,&nbsp;Ben Shofty ,&nbsp;Shervin Rahimpour ,&nbsp;Catherine A. Schevon ,&nbsp;John D. Rolston ,&nbsp;Elliot H. Smith","doi":"10.1016/j.brs.2025.06.017","DOIUrl":"10.1016/j.brs.2025.06.017","url":null,"abstract":"<div><h3>Background</h3><div>Currently approved human brain stimulation therapies, ranging from deep brain stimulation to responsive neuromodulation, use macro electrodes to deliver current to the brain. Despite daily clinical use, it remains fundamentally unknown how human neurons respond to intracranial stimulation.</div></div><div><h3>Objective</h3><div>We address this knowledge gap by characterizing cell-type-specific firing rate (FR) responses to broadly distributed single pulses of electrical stimulation as part of a common clinical procedure for epilepsy patients.</div></div><div><h3>Methods</h3><div>We recorded isolated neurons on microwires implanted into the medial temporal and frontal lobes of 30 epilepsy patients while stimulating macroelectrode contacts.</div></div><div><h3>Results</h3><div>Proportions of units classified as interneurons and principal cells corresponded with those previously reported. To see how stimulation affected neuronal activation, we calculated FR change between pre-stimulation and post-stimulation time windows and observed that from 174 modulated units 91 % showed FR suppression (Cohen's <em>h</em> = 0.77, large effect). We then characterized stimulation-evoked changes in FR to gain insight into cell-type-specific responses. Additionally, we observed that FR responses were modulated by stimulation distance, where local stimulation (within ∼40 mm) could evoke instantaneous firing, while distant stimulation reliably suppressed firing. Finally, we analyzed units within the seizure onset zone, revealing unique waveshapes and FR responses to stimulation.</div></div><div><h3>Conclusions</h3><div>This study bridges a gap in the neuromodulation field by examining the single-unit, cell-type-specific FR responses to direct electrical stimulation of the human brain. We show that low-frequency, single-pulse stimulation broadly elicits suppression, but parameters, such as distance, can have diverse effects on FR. This work informs the neuronal basis of stimulation-evoked potential generation, cell-type-specific responses to stimulation, and has clinical implications for the diagnosis and treatment of drug-resistant epilepsy.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1266-1278"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Subthalamic nucleus deep brain stimulation for patients with Parkinson's disease: comparison of active contact selection by clinical test vs beta band brain sensing” [Brain Stimul 18 (1) (2025) 406]","authors":"Matthias S.C. Chan ,&nbsp;Claire K.Y. Lau ,&nbsp;W.L. Cheung ,&nbsp;X.L. Zhu ,&nbsp;Danny T.M. Chan","doi":"10.1016/j.brs.2025.05.128","DOIUrl":"10.1016/j.brs.2025.05.128","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1249"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Evaluation of microstates and functional connectivity after transcranial direct current stimulation in post-covid syndrome” [Brain Stimul 18 (1) (2025) 503]","authors":"Nina Biačková ,&nbsp;Olga Laskov ,&nbsp;Andrea Adamová ,&nbsp;Václava Piorecká ,&nbsp;Jan Štrobl ,&nbsp;Stanislav Jiříček ,&nbsp;Jan Hubený ,&nbsp;Vlastimil Koudelka ,&nbsp;Monika Klírová","doi":"10.1016/j.brs.2025.05.122","DOIUrl":"10.1016/j.brs.2025.05.122","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1245"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}