Brain Stimulation最新文献

{"title":"Tetra codes: A precise, concise notation system for scalp-based neuronavigation","authors":"Yiru Li, Angel V. Peterchev, Jonathan Downar","doi":"10.1016/j.brs.2024.09.012","DOIUrl":"10.1016/j.brs.2024.09.012","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1142-1144"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory study of short-term treatment with adaptive neurostimulation in children with drug-resistant epilepsy","authors":"Tinghong Liu , Hanlei Li , Suhui Kuang , Liu Yuan, Weixing Feng, Hua Li, Ping Ding, Zhirong Wei, Shuli Liang","doi":"10.1016/j.brs.2024.09.013","DOIUrl":"10.1016/j.brs.2024.09.013","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1167-1169"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction and stabilization of delta frequency brain oscillations by phase-synchronized rTMS and tACS","authors":"Kuri Takahashi ,&nbsp;Benedikt Glinski ,&nbsp;Mohammed Ali Salehinejad ,&nbsp;Asif Jamil ,&nbsp;Acer Yu-Chan Chang ,&nbsp;Min-Fang Kuo ,&nbsp;Michael A. Nitsche","doi":"10.1016/j.brs.2024.09.003","DOIUrl":"10.1016/j.brs.2024.09.003","url":null,"abstract":"<div><h3>Background</h3><p>Brain oscillations in the delta frequency band have been linked with deep sleep and consolidation of declarative memory during sleep. However, the causal relationship of these associations remains not competely clarified, primarily due to constraints by technical limitations of brain stimulation approaches suited to induce and stabilize respective oscillatory activity in the human brain. The objective of this study was to establish a non-invasive brain stimulation protocol capable of reliably inducing, and stabilizing respective oscillatory activity in the delta frequency range.</p></div><div><h3>Hypothesis</h3><p>We aimed to develop an efficient non-invasive brain stimulation (NIBS) protocol for delta frequency induction and stabilization via concurrent, phase-locked repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS). We hypothesized that rTMS induces oscillatory resting-state activity in the delta frequency and that tACS stabilizes this effect, as has been shown before for alpha and theta frequencies.</p></div><div><h3>Methods</h3><p>19 healthy participants took part in a repeated-measures experimental protocol. We applied rTMS pulses synchronized with the peak or trough phase of 0.75Hz tACS over the bilateral prefrontal cortex. Resting state EEG in eyes-open (EO) and eyes-closed (EC) conditions was recorded before, immediately after and every 10 min for up to 1 h after intervention.</p></div><div><h3>Results</h3><p>rTMS phase-synchronized to the trough of the tACS waveform significantly increased delta frequency activity for up to 60 min in both EO and EC conditions after stimulation. The effects extended from frontal to temporal regions and this enhancement of oscillatory activity was shown to be specific for the delta frequency range.</p></div><div><h3>Conclusion</h3><p>Concurrent, trough-synchronized 0.75 Hz rTMS combined with tACS may be a reliable protocol to induce long-lasting oscillatory activity in the delta frequency range. The results of the current study might perspectively be relevant for clinical treatment of sleep disturbances which are accompanied by pathologically altered brain oscillations, and enhancement of memory consolidation.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1086-1097"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001578/pdfft?md5=d45c2d39befc51eb1228e15eb4daccfd&pid=1-s2.0-S1935861X24001578-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-cardiac coupling predicts heart rate regulation effects of neuro-cardiac-guided transcranial magnetic stimulation (TMS)","authors":"Chen Cheng ,&nbsp;Yunyun Jiao ,&nbsp;Mengnan Jia,&nbsp;Jiajie Jin,&nbsp;Xiangmiao Peng,&nbsp;Mengkai Zhang,&nbsp;Xiaoyu Song,&nbsp;Zhaoyang Chu,&nbsp;Xiao Zeng,&nbsp;Jin-Bo Sun,&nbsp;Xue-Juan Yang,&nbsp;Wei Qin","doi":"10.1016/j.brs.2024.09.007","DOIUrl":"10.1016/j.brs.2024.09.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1134-1136"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X2400161X/pdfft?md5=644d14c441d93f09811897ce5a6fb61d&pid=1-s2.0-S1935861X2400161X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early symptom improvement as a predictor of TMS treatment outcomes in posttraumatic stress disorder","authors":"Miriam A. Goldberg,&nbsp;Michelle R. Madore,&nbsp;F. Andrew Kozel,&nbsp;Noah S. Philip,&nbsp;Yosef A. Berlow","doi":"10.1016/j.brs.2024.09.009","DOIUrl":"10.1016/j.brs.2024.09.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1137-1139"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001621/pdfft?md5=da7399a970c9374e6210bee03e4f9d57&pid=1-s2.0-S1935861X24001621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where is the exit? The ethical importance of exit plans in clinical trials with neural implants","authors":"Franziska Britta Schönweitz ,&nbsp;Anja Kathrin Ruess ,&nbsp;Stuart McLennan ,&nbsp;Alena Buyx ,&nbsp;Marcello Ienca","doi":"10.1016/j.brs.2024.09.010","DOIUrl":"10.1016/j.brs.2024.09.010","url":null,"abstract":"<div><h3>Background</h3><div>As clinical trials involving implantable neural devices (INDs) increase in frequency and attract greater public attention, it is paramount to ensure they are conducted in alignment with fundamental ethical guidelines. Particular focus must be placed on the often underexplored aspect of trial termination for INDs.</div></div><div><h3>Objective</h3><div>To systematically review the ethical challenges encountered in clinical trials for INDs at the juncture of trial termination.</div></div><div><h3>Methods</h3><div>We conducted a rapid review using PubMed with two specific search queries, including all publications addressing ethical issues in the context of IND clinical trials. Priority was given to publications focusing on the end of treatment or the discontinuation of clinical studies or trials.</div></div><div><h3>Results</h3><div>We identified three primary groups of ethical challenges: patient-centric challenges, challenges faced by the research and physician team, and manufacturer-related issues. Further analysis highlights the importance of initiating early, transparent discussions regarding trial cessation protocols, ensuring that all stakeholders—patients, healthcare providers, researchers, and manufacturers—are equitably considered. Additionally, we found a discrepancy between current discontinuation strategies and international ethical guidelines. To address this, we emphasize the ethical obligation to establish comprehensive exit strategies that align with the principles in the Declaration of Helsinki and the CIOMS/WHO guidelines.</div></div><div><h3>Conclusion</h3><div>Our findings highlight the need for increased attention to the ethical and practical aspects of exit strategies and encourage further empirical research to address gaps in current practices. This would ensure that the discontinuation of IND trials is handled with ethical rigor, prioritizing the interests and well-being of all stakeholders involved.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1145-1154"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thalamic transcranial ultrasound stimulation in treatment resistant depression","authors":"Joline M. Fan,&nbsp;Kai Woodworth,&nbsp;Keith R. Murphy,&nbsp;Leighton Hinkley,&nbsp;Joshua L. Cohen,&nbsp;Joanne Yoshimura,&nbsp;Inhauck Choi,&nbsp;Alexandra G. Tremblay-McGaw,&nbsp;Joncarmen Mergenthaler,&nbsp;Cameron H. Good,&nbsp;Peter A. Pellionisz,&nbsp;A.Moses Lee,&nbsp;Tommaso Di Ianni,&nbsp;Leo P. Sugrue,&nbsp;Andrew D. Krystal","doi":"10.1016/j.brs.2024.08.006","DOIUrl":"10.1016/j.brs.2024.08.006","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1001-1004"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001475/pdfft?md5=c49533fc33c6274921bdc4bbdf1f4230&pid=1-s2.0-S1935861X24001475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic deep brain modulation: Enhancing neuronal activation and neurogenesis","authors":"Hwichan Ham ,&nbsp;Kyu Sik Kim ,&nbsp;Jee-Hwan Lee ,&nbsp;Do-Nyun Kim ,&nbsp;Hyung-Jin Choi ,&nbsp;Jack J. Yoh","doi":"10.1016/j.brs.2024.08.012","DOIUrl":"10.1016/j.brs.2024.08.012","url":null,"abstract":"<div><h3>Background</h3><p>Non-invasive deep brain modulation (DBM) stands as a promising therapeutic avenue to treat brain diseases. Acoustic DBM represents an innovative and targeted approach to modulate the deep brain, employing techniques such as focused ultrasound and shock waves. Despite its potential, the optimal mechanistic parameters, the effect in the brain and behavioral outcomes of acoustic DBM remains poorly understood.</p></div><div><h3>Objective</h3><p>To establish a robust protocol for the shock wave DBM by optimizing its mechanistic profile of external stimulation, and to assess its efficacy in preclinical settings.</p></div><div><h3>Methods</h3><p>We used shockwaves due to their capacity to leverage a broader spectrum of peak intensity (10–127 W/mm²) in contrast to ultrasound (0.1–5.0 W/mm²), thereby enabling a more extensive range of neuromodulation effects. We established various types of shockwave pressure profiles of DBM and compared neural and behavioral responses. To ascertain the anticipated cause of the heightened neural activity response, numerical analysis was employed to examine the mechanical dynamics within the brain.</p></div><div><h3>Results</h3><p>An optimized profile led to an enhancement in neuronal activity within the hypothalamus of mouse models. The optimized profile in the hippocampus elicited a marked increase in neurogenesis without neuronal damage. Behavioral analyses uncovered a noteworthy reduction in locomotion without significant effects on spatial memory function.</p></div><div><h3>Conclusions</h3><p>The present study provides an optimized shock wave stimulation protocol for non-invasive DBM. Our optimized stimulation profile selectively triggers neural functions in the deep brain. Our protocol paves the way for new non-invasive DBM devices to treat brain diseases.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1060-1075"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001530/pdfft?md5=1a24b63a995cebb49b792cc6bde1ed5b&pid=1-s2.0-S1935861X24001530-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient alteration of Awareness triggered by direct electrical stimulation of the brain","authors":"Julie Lévi-Strauss ,&nbsp;Julia Makhalova ,&nbsp;Samuel Medina Villalon ,&nbsp;Romain Carron ,&nbsp;Christian G. Bénar ,&nbsp;Fabrice Bartolomei","doi":"10.1016/j.brs.2024.08.013","DOIUrl":"10.1016/j.brs.2024.08.013","url":null,"abstract":"<div><h3>Background</h3><p>Awareness is a state of consciousness that enables a subject to interact with the environment. Transient alteration of awareness (AA) is a disabling sign of many types of epileptic seizures. The brain mechanisms of awareness and its alteration are not well known.</p></div><div><h3>Objective/Hypothesis</h3><p>Transient and isolated AA induced by electrical brain stimulation during a stereoelectroencephalography (SEEG) recording represents an ideal model for studying the associated modifications of functional connectivity and locating the hubs of awareness networks.</p></div><div><h3>Methods</h3><p>We investigated the SEEG signals-based brain functional connectivity (FC) changes vs background occurring during AA triggered by three thalamic and two insular stimulations in three patients explored by SEEG in the frame of presurgical evaluation for focal drug-resistant epilepsy. The results were compared to the stimulations of the same sites that did not induce clinical changes (negative stimulations).</p></div><div><h3>Results</h3><p>We observed decreased node strength in the pulvinar, insula, and parietal associative cortices during the thalamic and insular stimulations that induced AA. The link strengths characterizing functional coupling between the thalamus and the insular, prefrontal, temporal, or parietal associative cortices were also decreased. In contrast, there was an increased synchronization between the precuneus and the temporal lateral cortex. These FC changes were absent during the negative stimulations.</p></div><div><h3>Conclusion</h3><p>Our study highlights the role of the pulvinar, insular, and parietal hubs in maintaining the awareness networks and paves the way for invasive or non-invasive neuromodulation protocols to reduce AA manifestations during epileptic seizures.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1024-1033"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001542/pdfft?md5=ab805e1122237ec8c74b20c7571fdfe0&pid=1-s2.0-S1935861X24001542-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated deep TMS in alcohol use disorder: A preliminary pilot trial targeting the dorsal anterior cingulate cortex increases neural target engagement and abstinence","authors":"Claudia B. Padula ,&nbsp;Lea-Tereza Tenekedjieva ,&nbsp;Daniel M. McCalley,&nbsp;Jairelisse Morales Morales,&nbsp;Michelle R. Madore","doi":"10.1016/j.brs.2024.09.002","DOIUrl":"10.1016/j.brs.2024.09.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1098-1100"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001566/pdfft?md5=4e2073e3cf1b59f2ac8b6fc6d3275bc0&pid=1-s2.0-S1935861X24001566-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}