Brain Stimulation最新文献

{"title":"Transcranial temporal interference stimulation of the globus pallidus internus ameliorates gait variability in early- to mid-stage Parkinson's disease: A pilot study","authors":"Tingting Li , Chenhao Yang , Yongxin Xu , Yichao Du , Xiaonan Shen , Junhong Zhou , Yu Liu","doi":"10.1016/j.brs.2025.103007","DOIUrl":"10.1016/j.brs.2025.103007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 103007"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing the dialogue: What the 100-ms hippocampo-cortical lag tells us about memory-informed neuromodulation","authors":"Wei Wu , Ning Li , Huiyong Zhang","doi":"10.1016/j.brs.2025.103001","DOIUrl":"10.1016/j.brs.2025.103001","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 103001"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity transcranial ultrasound effects on the ventral intermediate nucleus and zona incerta in Parkinson's disease tremor","authors":"Maggie Q. Vuong ,&nbsp;Varsha Sreenivasan ,&nbsp;Soojin Lee ,&nbsp;Ben Quinn ,&nbsp;Martin S. Keung ,&nbsp;Michael Grundy ,&nbsp;Juana Ayala Castañeda ,&nbsp;Hongchae Baek ,&nbsp;Martin J. McKeown","doi":"10.1016/j.brs.2026.103025","DOIUrl":"10.1016/j.brs.2026.103025","url":null,"abstract":"<div><h3>Background</h3><div>Tremor in Parkinson's disease (PD) is a disabling symptom that often persists despite pharmacological treatment. High-intensity focused ultrasound (HIFU) targeting the ventral intermediate nucleus (VIM) alleviates Essential Tremor, but recent evidence suggests the zona incerta (ZI) may be a superior target for Parkinsonian tremor. This study compared the effects of transcranial ultrasound stimulation (TUS) to the VIM and ZI on postural and rest tremor, and examined related neural correlates using resting-state fMRI (rs-fMRI).</div></div><div><h3>Methods</h3><div>In this within-subject, crossover study, 19 participants with PD and right-hand tremor received both left VIM- and ZI-TUS on the same day in randomized order, separated by a 4-h washout period. Tremor severity and rs-fMRI data were collected before and after each session. Normalized changes in tremor intensity, resting-state functional connectivity (Δrs-FC), and fractional amplitude of low-frequency fluctuations (ΔfALFF) within the cerebello-thalamo-cortical network were analysed.</div></div><div><h3>Results</h3><div>TUS effects differed by target and tremor type. VIM-TUS significantly reduced postural tremor (p &lt; 0.001) but not rest tremor, whereas ZI-TUS improved both postural (p = 0.005) and rest (p = 0.005) tremor. Although no overall group-level rs-FC changes were observed, individual Δrs-FC of the ZI following ZI-TUS correlated with tremor improvement (postural: r = 0.762, p &lt; 0.001; rest: r = 0.586, p = 0.008), with similar findings for ΔfALFF.</div></div><div><h3>Conclusion</h3><div>ZI-TUS modulates tremor more robustly than VIM-TUS, suggesting that ZI may be a promising target for treatment of Parkinsonian tremor.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 103025"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation modulates ventral striatal physiology in children with severe self-injurious behaviour","authors":"Karim Mithani ,&nbsp;Sebastian C. Coleman ,&nbsp;Sara Breitbart ,&nbsp;Alfonso Fasano ,&nbsp;Carolina Gorodetsky ,&nbsp;George M. Ibrahim","doi":"10.1016/j.brs.2026.103026","DOIUrl":"10.1016/j.brs.2026.103026","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 103026"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-pulse interval and motor evoked potential variability: Bridging insights from healthy adults to post-stroke TMS protocols","authors":"Ergi Spiro ,&nbsp;Lei Zhu ,&nbsp;Ziping Huang ,&nbsp;Salman Ikramuddin ,&nbsp;Angel V. Peterchev ,&nbsp;Charalambos C. Charalambous ,&nbsp;Wuwei Feng","doi":"10.1016/j.brs.2025.102987","DOIUrl":"10.1016/j.brs.2025.102987","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 102987"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Brain injury during focused ultrasound neuromodulation for substance use disorder","authors":"Elsa Fouragnan","doi":"10.1016/j.brs.2025.102989","DOIUrl":"10.1016/j.brs.2025.102989","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 102989"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DLPFC TMS suppresses high-frequency neural activity in the human sgACC","authors":"Ethan A. Solomon ,&nbsp;Umair Hassan ,&nbsp;Nicholas T. Trapp ,&nbsp;Aaron D. Boes ,&nbsp;Corey J. Keller","doi":"10.1016/j.brs.2025.11.012","DOIUrl":"10.1016/j.brs.2025.11.012","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 102985"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TI-Toolbox: An open-source software for temporal interference stimulation research","authors":"Ido Haber ,&nbsp;Aksel Jackson ,&nbsp;Axel Thielscher ,&nbsp;Aviad Hai ,&nbsp;Giulio Tononi","doi":"10.1016/j.brs.2025.103016","DOIUrl":"10.1016/j.brs.2025.103016","url":null,"abstract":"<div><h3>Background</h3><div>Temporal interference (TI) stimulation is a novel non-invasive brain stimulation approach that promises selective targeting of deep brain structures while minimizing off-target cortical stimulation. Despite a growing interest in TI applications, there is a need for integrated computational tools that seamlessly connect neuroimaging data preprocessing through montage optimization, field simulation, and analysis within a unified framework designed for translational and clinical research.</div></div><div><h3>Methods</h3><div>We developed TI-Toolbox, an open-source software platform that integrates established neuroimaging tools (dcm2niix, SimNIBS, FreeSurfer) with specialized algorithms for TI research. The platform provides end-to-end workflows encompassing structural MRI preprocessing, volume conduction modeling, montage optimization, electric field simulation, and region-of-interest analysis. Both graphical user interface and command-line interface implementations ensure accessibility across user expertise levels. The platform employs containerized deployment via Docker to ensure reproducibility and cross-platform compatibility.</div></div><div><h3>Results</h3><div>TI-Toolbox successfully automates the complete TI research pipeline, from DICOM conversion through final field analysis. The platform demonstrates robust performance across operating systems and provides standardized workflows that enhance reproducibility. Furthermore, our case studies support the validity of our HD-EEG mapping approach for montage standardization and the need for individualized modeling for exposure assessment.</div></div><div><h3>Conclusions</h3><div>TI-Toolbox addresses critical infrastructure gaps in TI research by providing researchers with a unified, validated platform that reduces technical barriers and accelerates translational research in non-invasive deep brain stimulation.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 1","pages":"Article 103016"},"PeriodicalIF":8.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal asymmetric electric field pulses for selective transcranial magnetic stimulation with minimised power and coil heating","authors":"Ke Ma ,&nbsp;Andrey Vlasov ,&nbsp;Zeynep B. Simsek ,&nbsp;Jinshui Zhang ,&nbsp;Yiru Li ,&nbsp;Boshuo Wang ,&nbsp;David L.K. Murphy ,&nbsp;Jessica Y. Choi ,&nbsp;Maya E. Clinton ,&nbsp;Noreen Bukhari-Parlakturk ,&nbsp;Angel V. Peterchev ,&nbsp;Stephan M. Goetz","doi":"10.1016/j.brs.2025.09.009","DOIUrl":"10.1016/j.brs.2025.09.009","url":null,"abstract":"<div><h3>Background:</h3><div>Transcranial magnetic stimulation (TMS) with asymmetric electric field pulses, such as monophasic, offers directional selectivity for neural activation but requires excessive energy. Previous pulse shape optimisation has been limited to symmetric pulses or heavily constrained variations of conventional waveforms without achieving general optimality in energy efficiency or neural selectivity.</div></div><div><h3>Objective:</h3><div>We sought to develop a minimally constrained optimisation framework for identifying energy-efficient asymmetric TMS pulses with directional selectivity of neural stimulation.</div></div><div><h3>Methods:</h3><div>We implemented a novel optimisation framework that incorporates neuron model activation constraints and flexible control of pulse asymmetry. The optimised waveforms were experimentally validated against conventional and previously optimised pulses. We measured motor thresholds for conventional pulses as well as one of the optimised unidirectional rectangular (OUR) pulses and compared its MEP latency for anterior–posterior (AP) and posterior–anterior (PA) electric field directions in six healthy human subjects.</div></div><div><h3>Results:</h3><div>The optimised electric field waveforms had leading phases with a time constant of (280<!--> <span><math><mo>±</mo></math></span> <!--> <!-->15)<!--> <span><math><mi>μ</mi></math></span>s (mean<!--> <span><math><mo>±</mo></math></span> <!--> <!-->SD) and near-rectangular main stimulation phases. They achieved up to respectively 92<!--> <!-->% and 88<!--> <!-->% reduction in energy loss and thus heating compared to conventional monophasic pulses and previously improved monophasic-equivalent pulses. In the human experiments, OUR pulses demonstrated similar motor thresholds to monophasic pulses in both AP and PA directions whilst achieving significantly lower energy loss, particularly in the AP direction. Moreover, there was a significant MEP latency difference of (1.79<!--> <span><math><mo>±</mo></math></span> <!--> <!-->0.41)<!--> <!-->ms (mean<!--> <span><math><mo>±</mo></math></span> <!--> <!-->SE) between AP and PA direction with OUR pulses, suggesting directional selectivity.</div></div><div><h3>Conclusion:</h3><div>Our framework successfully identified highly energy-efficient asymmetric pulses for directionally-selective neural engagement. These pulses can enable selective rapid-rate repetitive TMS protocols with reduced power consumption and coil heating, with potential benefits for precision and potency of neuromodulation.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 6","pages":"Pages 1918-1929"},"PeriodicalIF":8.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of response to bilateral rTMS in late-life depression","authors":"Erin Adler ,&nbsp;Daniel M. Blumberger ,&nbsp;Xiao Chen ,&nbsp;Hyewon H. Lee ,&nbsp;Sean M. Nestor ,&nbsp;Jonathan Downar ,&nbsp;Benoit Mulsant ,&nbsp;Tarek K. Rajji ,&nbsp;Yoshihiro Noda ,&nbsp;Zafiris J. Daskalakis ,&nbsp;Tyler S. Kaster","doi":"10.1016/j.brs.2025.10.020","DOIUrl":"10.1016/j.brs.2025.10.020","url":null,"abstract":"<div><h3>Background</h3><div>Late-life depression is often resistant to standard treatment (LL-TRD) and presents unique clinical challenges due to comorbidities and cognitive decline. Repetitive transcranial magnetic stimulation (rTMS) is a promising option, yet responses are variable. Identifying trajectories of symptom change in LL-TRD in response to rTMS may clarify this heterogeneity and guide more personalized interventions.</div></div><div><h3>Methods</h3><div>This secondary analysis of a randomized rTMS trial in late-life depression used group-based trajectory modeling to identify depressive symptom response patterns. 172 participants aged 60+ were randomly assigned to one of two protocols: (1) bilateral rTMS, with low-frequency stimulation applied to the right dorsolateral prefrontal cortex (DLPFC) and high-frequency stimulation to the left; or (2) bilateral theta burst stimulation, with continuous TBS on the right DLPFC and intermittent TBS on the left. Multinomial regression identified baseline characteristics associated with trajectory membership.</div></div><div><h3>Results</h3><div>Four symptom trajectories were identified: Nonresponse, Partial Response, Linear Response and Rapid Response. Relative to Partial Response, higher Montgomery-Åsberg Depression Rating Scale (MADRS) scores were associated with lower odds of Rapid (OR = 0.79, 95 %CI:0.69–0.90) and Linear Response (OR = 0.87, 95 %CI:0.78–0.97), and higher odds of Nonresponse (OR = 1.33, 95 %CI:1.16–1.52). Benzodiazepine use was associated with lower odds of Linear Response (OR = 0.22, 95 %CI:0.08–0.56), while higher baseline anxiety was associated with higher odds of Nonresponse (OR = 1.13, 95 %CI:1.01–1.26).</div></div><div><h3>Conclusion</h3><div>This study identified four distinct rTMS response trajectories in LL-TRD and found that greater baseline depression severity and anxiety were associated with worse trajectories. These results support early clinical profiling to identify individuals at risk for nonresponse.</div></div><div><h3>Clinicaltrials</h3><div>gov identifier NCT02998580.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 6","pages":"Pages 2067-2074"},"PeriodicalIF":8.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}