Brain Stimulation最新文献

{"title":"tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats","authors":"Alireza Majdi ,&nbsp;Liyi Chen ,&nbsp;Lars E. Larsen ,&nbsp;Robrecht Raedt ,&nbsp;Myles Mc Laughlin","doi":"10.1016/j.brs.2025.01.025","DOIUrl":"10.1016/j.brs.2025.01.025","url":null,"abstract":"<div><h3>Background</h3><div>The effects of transcranial direct current stimulation (tDCS) are generally thought to result from the polarization of cortical neurons by the weak electric fields it creates. However, recent evidence suggests that some tDCS effects may be mediated through co-stimulation of peripheral or cranial nerves, particularly the trigeminal nerve (TN). The TN projects to key brainstem nuclei that regulate neurotransmitter release throughout the central nervous system, but the specific pathways involved are not yet well understood.</div></div><div><h3>Methods</h3><div>In this study, we examined the effects of acute transcutaneous TN direct current stimulation (TN-DCS) on tonic (i.e. mean spike rate) and phasic (number of bursts, spike rate per burst, burst duration, and inter-burst interval) activities while simultaneously recording single-neuron activity across three brainstem nuclei in rats: the locus coeruleus (LC; phasic and tonic activities), dorsal raphe nucleus (DRN; tonic activity), and median raphe nucleus (MnRN; tonic activity).</div></div><div><h3>Results</h3><div>TN-DCS significantly modulated tonic activity in the LC and DRN, with interactions between amplitude, polarity, and time affecting mean spike rates. It also influenced phasic activity in the LC, altering burst number, duration, and inter-burst intervals. In contrast, MnRN tonic activity was unchanged. Blocking TN with xylocaine eliminated the effects on tonic activity in both the LC and DRN.</div></div><div><h3>Conclusions</h3><div>These results suggest that tDCS may modulate the TN, altering DRN and LC activity. Differential changes in tonic and phasic LC activity highlight their roles in TN-DCS effects on the cortex. This research offers insights to improve tDCS efficacy and understanding. <strong>Keywords</strong>: tDCS; trigeminal nerve; locus coeruleus; Dorsal raphe nucleus; median raphe nucleus.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 171-184"},"PeriodicalIF":7.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease","authors":"Maria Olaru ,&nbsp;Amelia Hahn ,&nbsp;Maria Shcherbakova ,&nbsp;Simon Little ,&nbsp;Wolf-Julian Neumann ,&nbsp;Reza Abbasi-Asl ,&nbsp;Philip A. Starr","doi":"10.1016/j.brs.2025.01.011","DOIUrl":"10.1016/j.brs.2025.01.011","url":null,"abstract":"<div><h3>Background</h3><div>In Parkinson's disease, invasive brain recordings show that dopaminergic medication can induce narrowband gamma rhythms in the motor cortex and subthalamic nucleus, which co-fluctuate with dyskinesia scores. Deep brain stimulation can entrain these gamma oscillations to a subharmonic stimulation frequency. However, the incidence of entrainment during chronic therapeutic stimulation, its relationship to the basal ganglia stimulation site, and its effect on dyskinesia remain unknown.</div></div><div><h3>Objective</h3><div>Determine whether the behavioral effects and statistical properties of levodopa-induced gamma oscillations are altered when entrained with deep brain stimulation.</div></div><div><h3>Methods</h3><div>We used a sensing-enabled deep brain stimulator system, attached to both motor cortex and subthalamic (<em>n</em> = 15) or pallidal (<em>n</em> = 5) leads, to record 993 h of multisite field potentials, with 656 h recorded prior to initiating stimulation. 13 subjects (20 hemispheres) with Parkinson's disease (1/13 female, mean age 59 ± 9 years) streamed data while at home on their usual antiparkinsonian medication. Recordings during stimulation occurred at least five months after initiating stimulation.</div></div><div><h3>Results</h3><div>Cortical entrained gamma oscillations were detected in 4/5 hemispheres undergoing pallidal stimulation and 12/15 hemispheres undergoing subthalamic stimulation. Entraining levodopa-induced gamma oscillations at either site reduced their prodyskinetic effects. Cortical entrained gamma oscillations had reduced variance in peak frequency, increased spectral power, and higher variance in spectral power than levodopa-induced gamma oscillations.</div></div><div><h3>Conclusion</h3><div>Stimulation-entrained gamma oscillations are functionally and physiologically distinct from levodopa-induced gamma oscillations that occur in the absence of deep brain stimulation. Understanding the discrepancies between types of gamma oscillations may improve programming protocols.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 132-141"},"PeriodicalIF":7.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion in the path of current flow to target pericavitational and perilesional brain areas: Acute network-level tDCS findings in chronic aphasia using concurrent tDCS/fMRI","authors":"Venkatagiri Krishnamurthy ,&nbsp;Serena E. Song ,&nbsp;Lisa C. Krishnamurthy ,&nbsp;Simone Renée Roberts ,&nbsp;Joo H. Han ,&nbsp;Amy D. Rodriguez ,&nbsp;Samir R. Belagaje ,&nbsp;Marcus Meinzer ,&nbsp;Bruce A. Crosson","doi":"10.1016/j.brs.2025.01.024","DOIUrl":"10.1016/j.brs.2025.01.024","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 145-147"},"PeriodicalIF":7.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vagal nerve stimulation dynamically alters anxiety-like behavior in rats","authors":"A.G. Butler ,&nbsp;J.K. Bassi ,&nbsp;A.A. Connelly ,&nbsp;M.R. Melo ,&nbsp;A.M. Allen ,&nbsp;S.J. McDougall","doi":"10.1016/j.brs.2025.01.018","DOIUrl":"10.1016/j.brs.2025.01.018","url":null,"abstract":"<div><h3>Background</h3><div>Electrical vagal nerve stimulation (VNS), at currents designed to target sensory, interoceptive neurons, decreases anxiety-like behavior.</div></div><div><h3>Objective/Hypothesis</h3><div>We hypothesized that different VNS current intensities would differentially alter anxiety-like behavior through the activation of distinct brainstem circuits.</div></div><div><h3>Methods</h3><div>Electrodes were implanted to stimulate the left vagus nerve and to record diaphragm muscle and electrocardiogram activity. The VNS current required to elicit the A-fiber-mediated Hering-Breuer Reflex (HBR) was determined for each animal. Based on this threshold, animals received either sham stimulation or VNS at 1.5 (mid-intensity VNS) or 3 (higher-intensity VNS) times the threshold for HBR activation. Anxiety-like behavior was assessed using the elevated plus maze, open field test, and novelty-suppressed feeding test. Additionally, a place preference assay determined whether VNS is rewarding or aversive. Finally, a c-Fos assay was performed to evaluate VNS-driven neuronal activation within the brainstem.</div></div><div><h3>Results</h3><div>Mid-intensity VNS reduced anxiety-like behavior in the elevated plus maze and open field test. Higher-intensity VNS was aversive during the place preference assay, confounding anxiety measures. Both intensities increased overall c-Fos expression in neurons within the nucleus of the solitary tract, but mid-intensity VNS specifically increased c-Fos expression in noradrenergic neurons within the nucleus of the solitary tract while decreasing it in the locus coeruleus. In contrast, higher-intensity VNS had no effect on c-Fos expression in noradrenergic neurons of either the nucleus of the solitary tract or locus coeruleus.</div></div><div><h3>Conclusion</h3><div>Delivery of VNS induced reproducible, current intensity-dependent, effects on anxiety-like and aversive behavior in rats.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 158-170"},"PeriodicalIF":7.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis","authors":"Ipek Pervaz ,&nbsp;Lilly Thurn ,&nbsp;Cecilia Vezzani ,&nbsp;Luisa Kaluza ,&nbsp;Anne Kühnel ,&nbsp;Nils B. Kroemer","doi":"10.1016/j.brs.2025.01.022","DOIUrl":"10.1016/j.brs.2025.01.022","url":null,"abstract":"<div><h3>Background</h3><div>Transcutaneous vagus nerve stimulation (tVNS) has emerged as a promising technique to modulate autonomic functions, and pupil dilation has been recognized as a promising biomarker for tVNS-induced monoaminergic release. Nevertheless, studies on the effectiveness of various tVNS protocols have produced heterogeneous results on pupil dilation to date.</div></div><div><h3>Methods</h3><div>Here, we synthesize the existing evidence and compare conventional (“continuous”) and pulsed stimulation protocols using a Bayesian meta-analysis. To maintain a living version, we developed a Shiny App with the possibility to incorporate newly published studies in the future. Based on a systematic review, we included 18 studies (N = 771) applying either conventional or pulsed stimulation protocols.</div></div><div><h3>Results</h3><div>Across studies, we found anecdotal evidence for the null hypothesis, showing that taVNS does not increase pupil size (<em>g</em> = 0.15, 95 % CI = [0.03, 0.27], BF₀₁ = 1.0). Separating studies according to conventional vs. pulsed protocols revealed that studies using pulsed taVNS provide strong evidence for the alternative hypothesis(<em>g</em> = 0.36, 95 % CI = [0.19, 0.53], BF₁₀ = 50.8) while conventional taVNS studies provide strong evidence for the null hypothesis (<em>g</em> = 0.002, CI = [-0.14, 0.14], BF₀₁ = 21.9).</div></div><div><h3>Conclusion</h3><div>Our meta-analysis highlights differential effects of conventional and pulsed taVNS protocols on pupil dilation. These findings underscore the relevance of taVNS protocols in optimizing its use for specific applications that may require modulation of tonic vs. phasic monoaminergic responses and might also help to gain mechanistic insights into potential therapeutic effects.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 148-157"},"PeriodicalIF":7.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of pulse amplitude in electroconvulsive therapy on seizure threshold, seizure duration, and time to reorientation","authors":"Maya Hazimeh ,&nbsp;Harold A. Sackeim ,&nbsp;Ziad Nahas","doi":"10.1016/j.brs.2025.01.023","DOIUrl":"10.1016/j.brs.2025.01.023","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 116-118"},"PeriodicalIF":7.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian Optimization Of NeuroStimulation (BOONStim)","authors":"Lindsay D. Oliver ,&nbsp;Jerrold Jeyachandra ,&nbsp;Erin W. Dickie ,&nbsp;Colin Hawco ,&nbsp;Salim Mansour ,&nbsp;Stephanie M. Hare ,&nbsp;Robert W. Buchanan ,&nbsp;Anil K. Malhotra ,&nbsp;Daniel M. Blumberger ,&nbsp;Zhi-De Deng ,&nbsp;Aristotle N. Voineskos","doi":"10.1016/j.brs.2025.01.020","DOIUrl":"10.1016/j.brs.2025.01.020","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 112-115"},"PeriodicalIF":7.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High intensity transcranial altering current stimulation for cognitive dysfunction in schizophrenia: A pilot trial","authors":"Zifan You ,&nbsp;Zhangyin He ,&nbsp;Luyao Zou ,&nbsp;Shanshan Chen ,&nbsp;Jinsong Tang","doi":"10.1016/j.brs.2025.01.021","DOIUrl":"10.1016/j.brs.2025.01.021","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 119-121"},"PeriodicalIF":7.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of coil orientation on the TMS-induced electric field within the clinically recommended brain region for major depressive disorder","authors":"JianKang Wu ,&nbsp;He Wang ,&nbsp;Jingna Jin ,&nbsp;Xin Wang ,&nbsp;Ying Li ,&nbsp;Zhipeng Liu ,&nbsp;Tao Yin","doi":"10.1016/j.brs.2025.01.017","DOIUrl":"10.1016/j.brs.2025.01.017","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 109-111"},"PeriodicalIF":7.6,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease","authors":"Oluwatofunmi A. Abiola ,&nbsp;Collin M. Lehmann ,&nbsp;Khaled Moussawi ,&nbsp;Hawre Jalal","doi":"10.1016/j.brs.2025.01.014","DOIUrl":"10.1016/j.brs.2025.01.014","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use disorder (AUD) is a major public health concern and cause of mortality and morbidity. Alcohol-associated liver disease (ALD) is a debilitating complication of AUD, mitigated by abstinence from alcohol use. Deep brain stimulation (DBS) is emerging as a potential treatment for AUD. However, its cost-effectiveness compared to the standard medical treatment is unclear.</div></div><div><h3>Objective</h3><div>To estimate the cost-effectiveness of DBS compared to medical management for patients with AUD and ALD.</div></div><div><h3>Methods</h3><div>We utilized a decision analytic model based on published literature to conduct a cost-effectiveness analysis of costs and health outcomes for DBS and medical management in patients with AUD and ALD. We also carried out a threshold analysis to determine the probability of success necessary for DBS to be cost-effective. Costs were measured in 2024 US dollars and effectiveness in quality-adjusted life years (QALYs). We used a time horizon of 1–2 years and adopted a societal perspective.</div></div><div><h3>Results</h3><div>Our results show that for AUD patients in general, DBS is not cost-effective at any DBS success rate. However, for advanced ALD patients, defined as fibrosis stage 3 or beyond DBS becomes cost-effective. For these patients, DBS is cost-effective over a two-year period at a $100,000 willingness-to-pay threshold at DBS success rates greater than 53 %. For advanced decompensated ALD patients, DBS is cost-effective over a one-year period at DBS success rate greater than 35 %.</div></div><div><h3>Conclusion</h3><div>Should it prove efficacious, DBS may be cost-effective for patients with AUD and ALD. Thus, future randomized controlled trials to evaluate its efficacy are warranted.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 122-131"},"PeriodicalIF":7.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}