Brain Stimulation最新文献

{"title":"Transcutaneous vagus nerve stimulation boosts accuracy during perceptual decision-making","authors":"Shiyong Su ,&nbsp;Thomas Vanvoorden ,&nbsp;Pierre Le Denmat ,&nbsp;Alexandre Zénon ,&nbsp;Clara Braconnier ,&nbsp;Julie Duque","doi":"10.1016/j.brs.2025.04.020","DOIUrl":"10.1016/j.brs.2025.04.020","url":null,"abstract":"<div><h3>Background</h3><div>The locus coeruleus-norepinephrine (LC-NE) system is a well-established regulator of behavior, yet its precise role remains unclear. Animal studies predominantly support a “gain” hypothesis, suggesting that the LC-NE system enhances sensory processing. In contrast, human studies have proposed an alternative “urgency” hypothesis, postulating that LC-NE primarily accelerates responses.</div></div><div><h3>Method</h3><div>To address this discrepancy, we administered transcutaneous vagus nerve stimulation (tVNS) in two experiments. In the first experiment (n = 22), we showed that 4-s tVNS trains reliably induced greater pupil dilation compared to SHAM condition, indicating increased LC-NE activity. In the second experiment (n = 21), we applied tVNS during a random dot motion task to assess its impact on perceptual decision-making.</div></div><div><h3>Result</h3><div>tVNS improved accuracy without affecting reaction times, which appears inconsistent with the “urgency” hypothesis. Exploratory drift-diffusion model analyses further support the “gain” hypothesis, revealing that tVNS increased the drift rate, indicative of enhanced evidence accumulation. Both accuracy and drift-rate improvements were most prominent following errors and especially pronounced in participants who exhibited post-error declines in these measures under SHAM.</div></div><div><h3>Conclusion</h3><div>Our findings align with the “gain” hypothesis, with tentative evidence suggesting that the impact of LC-NE activity adapts to task demands. Accordingly, tVNS showed the strongest effects in contexts prone to accuracy declines, possibly reflecting attentional disengagement, which points to a role of LC in mitigating lapses of attention.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 975-986"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous auricular vagus nerve stimulation for acquired immune deficiency syndrome patients with depressive symptoms: a pilot randomized clinical trial","authors":"Ningyi Zou ,&nbsp;Qing Zhou ,&nbsp;Zongshi Qin ,&nbsp;Liqin Ma ,&nbsp;Haibo Wang ,&nbsp;Li Su ,&nbsp;Sheharyar S. Baig ,&nbsp;Na Dong ,&nbsp;Fenxiang Li ,&nbsp;Shiqi Diao ,&nbsp;Jian Wang ,&nbsp;Chengjie Ma ,&nbsp;Peijing Rong ,&nbsp;Guojian Gao ,&nbsp;Shaoyuan Li","doi":"10.1016/j.brs.2025.04.022","DOIUrl":"10.1016/j.brs.2025.04.022","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 987-989"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep transcranial ultrasound stimulation using personalized acoustic metamaterials improves treatment-resistant depression in humans","authors":"David Attali ,&nbsp;Thomas Tiennot ,&nbsp;Thomas J. Manuel ,&nbsp;Maxime Daniel ,&nbsp;Alexandre Houdouin ,&nbsp;Philippe Annic ,&nbsp;Alexandre Dizeux ,&nbsp;Alexandre Haroche ,&nbsp;Ghita Dadi ,&nbsp;Adèle Henensal ,&nbsp;Mylène Moyal ,&nbsp;Alice Le Berre ,&nbsp;Cécile Paolillo ,&nbsp;Sylvain Charron ,&nbsp;Clément Debacker ,&nbsp;Maliesse Lui ,&nbsp;Sabrina Lekcir ,&nbsp;Rosella Mancusi ,&nbsp;Thierry Gallarda ,&nbsp;Tarek Sharshar ,&nbsp;Marion Plaze","doi":"10.1016/j.brs.2025.04.018","DOIUrl":"10.1016/j.brs.2025.04.018","url":null,"abstract":"<div><h3>Background</h3><div>Neuromodulation of deep brain regions has shown promise for treatment-resistant depression (TRD). However, it currently requires neurosurgical electrode implantation, posing significant risks and limiting widespread use while TRD affects around 100 million people worldwide. Low-intensity transcranial ultrasound stimulation (TUS) could allow precise and non-invasive deep neuromodulation, provided that the challenge of the defocusing effects of the skull is tackled.</div></div><div><h3>Objective/hypothesis</h3><div>Here, we present the development of a portable and neuronavigated TUS prototype based on the use of patient-specific metamaterials (metalens) that correct for skull-induced aberrations. We then present the first application of metalens-based Transcranial Ultrasound Stimulation (mTUS) in TRD. The primary objective was to assess the safety and efficacy of mTUS targeting on individual level specific white matter tracts of the subcallosal cingulate involved in TRD.</div></div><div><h3>Methods</h3><div>The safety and precision of this device was addressed through a series of numerical simulations and experimental measurements on <em>ex vivo</em> human skulls. Five participants with TRD were included in this open-label study (ClinicalTrials.gov identifier: NCT06085950) and underwent an intensive 5-day course of mTUS with a total of 25 sessions of 5 min each.</div></div><div><h3>Results</h3><div>No serious adverse events occurred during the study. By day 5 of treatment, depression severity was reduced by an average of 60.9 % (range: [30 %–83.9 %]), and four out of five patients qualified as responders, with two of them in remission.</div></div><div><h3>Conclusions</h3><div>This study provides first-in-human evidence of the potential of mTUS as a precise, safe and effective non-invasive neuromodulation technique for neuropsychiatric disorders involving deep brain regions, offering a safer and more accessible alternative to invasive approaches.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 1004-1014"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prior-information Robbins–Monro sequence for rapid motor thresholding of transcranial magnetic stimulation","authors":"Siwei Liu,&nbsp;Boshuo Wang,&nbsp;Ke Ma,&nbsp;Xuyi Hu,&nbsp;Lari M. Koponen,&nbsp;Angel V. Peterchev,&nbsp;S.M. Mahdi Alavi,&nbsp;Stephan M. Goetz","doi":"10.1016/j.brs.2025.03.017","DOIUrl":"10.1016/j.brs.2025.03.017","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 1015-1018"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations","authors":"Isaac Grennan ,&nbsp;Brook Perry ,&nbsp;Anna Verghese ,&nbsp;Melissa Jones ,&nbsp;Oliver Härmson ,&nbsp;Colin G. McNamara ,&nbsp;Andrew Sharott","doi":"10.1016/j.brs.2025.04.019","DOIUrl":"10.1016/j.brs.2025.04.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Alzheimer's disease (AD) has very limited treatment options and therapies to prevent or reverse neurodegeneration remain elusive. Deep brain stimulation (DBS), whereby high-frequency pulses of electricity are delivered continuously to a specific part of the brain, has been trialled as an experimental treatment for AD. In AD patients, continuous, high frequency DBS targeted to the fornix (fx-DBS) has been shown to be safe, but not reliably effective across patients. In movement disorders, high-frequency DBS is thought to act as a virtual lesion, disrupting pathophysiological activity. In AD, it may be more advantageous to use stimulation to reinforce or rebuild oscillatory activities that are disrupted by the disease process. A primary candidate for such a target is the hippocampal theta oscillation, which provides a temporal framework for mnemonic processing and is altered in rodent models of AD.</div></div><div><h3>Material and methods</h3><div>We applied closed-loop electrical stimulation to the fornix of rats traversing a linear track, triggered by different phases of the ongoing theta oscillation in the hippocampal local field potential (LFP) using the OscillTrack algorithm.</div></div><div><h3>Results</h3><div>Stimulation at different target phases could robustly suppress or amplify the theta oscillation, and these effects were significantly larger than those caused by open-loop replay of the same stimulation pattern. Amplification of the theta oscillation could be achieved irrespective of the locomotor speed of the animal, showing that it did not result from a secondary effect of behavioural change.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that closed-loop fx-DBS is a viable method of modulating the amplitude of hippocampal theta oscillations that could be applied in human devices to provide a constructive intervention with the potential to boost memory circuit function in AD.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 993-1003"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety considerations for transcranial ultrasound stimulation: A comment on Nandi et al.","authors":"Jean-François Nankoo ,&nbsp;Massimo Pascuzzi ,&nbsp;Robert Chen","doi":"10.1016/j.brs.2025.03.018","DOIUrl":"10.1016/j.brs.2025.03.018","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 1019-1020"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dependency of TMS-evoked potentials on electric-field orientation in the cortex","authors":"Ida Granö ,&nbsp;Tuomas P. Mutanen ,&nbsp;Aino E. Nieminen ,&nbsp;Jaakko O. Nieminen ,&nbsp;Victor H. Souza ,&nbsp;Risto J. Ilmoniemi ,&nbsp;Pantelis Lioumis","doi":"10.1016/j.brs.2025.04.021","DOIUrl":"10.1016/j.brs.2025.04.021","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 990-992"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation","authors":"Danielle Lauren Kurtin ,&nbsp;Ketevan Alania ,&nbsp;Edward Rhodes ,&nbsp;Samuel Vincent ,&nbsp;Ines R. Violante ,&nbsp;Nir Grossman","doi":"10.1016/j.brs.2025.04.010","DOIUrl":"10.1016/j.brs.2025.04.010","url":null,"abstract":"<div><h3>Background</h3><div>Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acutely modulate activity or FC traces of preceding cognitive tasks.</div></div><div><h3>Objectives</h3><div>We evaluated whether non-invasive temporal interference (TI) stimulation of the hippocampus can modulate hippocampal resting-state FC traces induced by a preceding hippocampally-dependent task.</div></div><div><h3>Methods</h3><div>We collected resting-state functional magnetic resonance imaging (rsfMRI) in twenty healthy participants before and after the performance of an associative memory task. Theta-band TI stimulation of the medial and anterior hippocampus, and sham stimulation were delivered during post-task resting state. We used permutation tests to assess differences in pairwise mutual information functional connectivity (miFC) between pre-task rsfMRI vs post-task sham. In edges with significantly different pre-vs post-task miFC, permutation tests assessed the effect of TI on post-task miFC.</div></div><div><h3>Results</h3><div>MiFC was significantly lower in several functional networks during post-task sham compared to pre-task baseline, including the hippocampal-connected and task-related Anterior Temporal (AT) and Posterior Medial (PM) networks. TI stimulation of the hippocampus during post-task resting state increased the miFC in the hippocampal AT and PM networks as well as other functional networks.</div></div><div><h3>Conclusions</h3><div>Non-invasive TI stimulation of the hippocampus during the resting state acutely modulated FC traces related to preceding hippocampal-dependent memory tasks.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 937-947"},"PeriodicalIF":7.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging macroscopic and microscopic modeling of electric field by brain stimulation","authors":"Boshuo Wang ,&nbsp;Aman S. Aberra","doi":"10.1016/j.brs.2025.04.009","DOIUrl":"10.1016/j.brs.2025.04.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 897-899"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network-level high definition tDCS in a complex patient presentation","authors":"Alexandru D. Iordan ,&nbsp;Victor Di Rita ,&nbsp;Brett S. Schneider ,&nbsp;Sami J. Barmada ,&nbsp;Benjamin M. Hampstead","doi":"10.1016/j.brs.2025.04.016","DOIUrl":"10.1016/j.brs.2025.04.016","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 882-884"},"PeriodicalIF":7.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}