Brain Stimulation最新文献

{"title":"TMS-associated auditory evoked potentials can be effectively masked: Evidence from intracranial EEG","authors":"Nicholas T. Trapp , Eric W. Tsang , Joel Bruss, Simone Russo, Phillip E. Gander, Joel I. Berger, Kirill V. Nourski, Mario Rosanova, Corey J. Keller, Hiroyuki Oya, Matthew A. Howard III, Aaron D. Boes","doi":"10.1016/j.brs.2024.05.002","DOIUrl":"10.1016/j.brs.2024.05.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 616-618"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000846/pdfft?md5=771d4385adb7c8f5460f10872dda9b62&pid=1-s2.0-S1935861X24000846-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External stimulation of the trigeminal nerve causes pupil dilation in healthy volunteers, suggesting locus coeruleus modulation","authors":"Nina Seminck, Ahmad Khatoun, Silke Kerstens, Bart Nuttin, Myles Mc Laughlin","doi":"10.1016/j.brs.2024.05.008","DOIUrl":"10.1016/j.brs.2024.05.008","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 678-680"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000901/pdfft?md5=3a2a57ce0a3124cc50be9cdfc77326da&pid=1-s2.0-S1935861X24000901-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensity-dependent effects of tDCS on motor learning are related to dopamine","authors":"Li-Ann Leow ,&nbsp;Jiaqin Jiang ,&nbsp;Samantha Bowers ,&nbsp;Yuhan Zhang ,&nbsp;Paul E. Dux ,&nbsp;Hannah L. Filmer","doi":"10.1016/j.brs.2024.03.015","DOIUrl":"https://doi.org/10.1016/j.brs.2024.03.015","url":null,"abstract":"<div><p>Non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), are popular methods for inducing neuroplastic changes to alter cognition and behaviour. One challenge for the field is to optimise stimulation protocols to maximise benefits. For this to happen, we need a better understanding of <em>how</em> stimulation modulates cortical functioning/behaviour. To date, there is increasing evidence for a dose-response relationship between tDCS and brain excitability, however how this relates to behaviour is not well understood. Even less is known about the neurochemical mechanisms which may drive the dose-response relationship between stimulation intensities and behaviour. Here, we examine the effect of three different tDCS stimulation intensities (1 mA, 2 mA, 4 mA anodal motor cortex tDCS) administered during the explicit learning of motor sequences. Further, to assess the role of dopamine in the dose-response relationship between tDCS intensities and behaviour, we examined how pharmacologically increasing dopamine availability, via 100 mg of levodopa, modulated the effect of stimulation on learning. In the absence of levodopa, we found that 4 mA tDCS improved and 1 mA tDCS impaired acquisition of motor sequences relative to sham stimulation. Conversely, levodopa reversed the beneficial effect of 4 mA tDCS. This effect of levodopa was no longer evident at the 48-h follow-up, consistent with previous work characterising the persistence of neuroplastic changes in the motor cortex resulting from combining levodopa with tDCS. These results provide the first direct evidence for a role of dopamine in the intensity-dependent effects of tDCS on behaviour.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 553-560"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000512/pdfft?md5=2b5366658698bacfd8a980c96f7d95f6&pid=1-s2.0-S1935861X24000512-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140825526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITRUSST consensus on standardised reporting for transcranial ultrasound stimulation","authors":"Eleanor Martin ,&nbsp;Jean-François Aubry ,&nbsp;Mark Schafer ,&nbsp;Lennart Verhagen ,&nbsp;Bradley Treeby ,&nbsp;Kim Butts Pauly","doi":"10.1016/j.brs.2024.04.013","DOIUrl":"10.1016/j.brs.2024.04.013","url":null,"abstract":"<div><p>As transcranial ultrasound stimulation (TUS) advances as a precise, non-invasive neuromodulatory method, there is a need for consistent reporting standards to enable comparison and reproducibility across studies. To this end, the International Transcranial Ultrasonic Stimulation Safety and Standards Consortium (ITRUSST) formed a subcommittee of experts across several domains to review and suggest standardised reporting parameters for low intensity TUS, resulting in the guide presented here. The scope of the guide is limited to reporting the ultrasound aspects of a study. The guide and supplementary material provide a simple checklist covering the reporting of: (1) the transducer and drive system, (2) the drive system settings, (3) the free field acoustic parameters, (4) the pulse timing parameters, (5) <em>in situ</em> estimates of exposure parameters in the brain, and (6) intensity parameters. Detailed explanations for each of the parameters, including discussions on assumptions, measurements, and calculations, are also provided.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 607-615"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000718/pdfft?md5=a31474b71d1d918ebee5fef1285878e2&pid=1-s2.0-S1935861X24000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation alters cerebrospinal fluid-interstitial fluid exchange in mouse brain","authors":"Yan Wang,&nbsp;Hiromu Monai","doi":"10.1016/j.brs.2024.04.009","DOIUrl":"10.1016/j.brs.2024.04.009","url":null,"abstract":"<div><h3>Background</h3><p>Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has gained prominence recently. Clinical studies have explored tDCS as an adjunct to neurologic disease rehabilitation, with evidence suggesting its potential in modulating brain clearance mechanisms. The glymphatic system, a proposed brain waste clearance system, posits that cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange aids in efficient metabolic waste removal. While some studies have linked tDCS to astrocytic inositol trisphosphate (IP₃)/Ca²⁺ signaling, the impact of tDCS on CSF-ISF exchange dynamics remains unclear.</p></div><div><h3>Hypothesis</h3><p>tDCS influences the dynamics of CSF-ISF exchange through astrocytic IP₃/Ca²⁺ signaling.</p></div><div><h3>Methods</h3><p>In this study, we administered tDCS (0.1 mA for 10 min) to C57BL/6N mice anesthetized with ketamine-xylazine (KX). The anode was positioned on the cranial bone above the cortex, and the cathode was inserted into the neck. Following tDCS, we directly assessed brain fluid dynamics by injecting biotinylated dextran amine (BDA) as a CSF tracer into the cisterna magna (CM). The brain was then extracted after either 30 or 60 min and fixed. After 24 h, the sectioned brain slices were stained with Alexa 594-conjugated streptavidin (SA) to visualize BDA using immunohistochemistry. We conducted Electroencephalography (EEG) recordings and aquaporin 4 (AQP4)/CD31 immunostaining to investigate the underlying mechanisms of tDCS. Additionally, we monitored the efflux of Evans blue, injected into the cisterna magna, using cervical lymph node imaging. Some experiments were subsequently repeated with inositol trisphosphate receptor type 2 (IP₃R2) knockout (KO) mice.</p></div><div><h3>Results</h3><p>Post-tDCS, we observed an increased CSF tracer influx, indicating a modulation of CSF-ISF exchange by tDCS. Additionally, tDCS appeared to enhance the brain's metabolic waste efflux. EEG recordings showed an increase in delta wave post-tDCS. But no significant change in AQP4 expression was detected 30 min post-tDCS. Besides, we found no alteration in CSF-ISF exchange and delta wave activity in IP₃R2 KO mice after tDCS.</p></div><div><h3>Conclusion</h3><p>Our findings suggest that tDCS augments the glymphatic system's influx and efflux. Through astrocytic IP₃/Ca²⁺ signaling, tDCS was found to modify the delta wave, which correlates positively with brain clearance. This study underscores the potential of tDCS in modulating brain metabolic waste clearance.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 620-632"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000676/pdfft?md5=cb908e1fe9de4108c30e076d05855fb3&pid=1-s2.0-S1935861X24000676-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decomposing the effects of α-tACS on brain oscillations and aperiodic 1/f activity","authors":"Florian H. Kasten ,&nbsp;René Lattmann ,&nbsp;Daniel Strüber,&nbsp;Christoph S. Herrmann","doi":"10.1016/j.brs.2024.05.015","DOIUrl":"10.1016/j.brs.2024.05.015","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 721-723"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000974/pdfft?md5=240461f55f320f5b640ed46e4f0f1603&pid=1-s2.0-S1935861X24000974-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial electric stimulation modulates firing rate at clinically relevant intensities","authors":"Forouzan Farahani ,&nbsp;Niranjan Khadka ,&nbsp;Lucas C. Parra ,&nbsp;Marom Bikson ,&nbsp;Mihály Vöröslakos","doi":"10.1016/j.brs.2024.04.007","DOIUrl":"10.1016/j.brs.2024.04.007","url":null,"abstract":"<div><h3>Background</h3><p>Notwithstanding advances with low-intensity transcranial electrical stimulation (tES), there remain questions about the efficacy of clinically realistic electric fields on neuronal function.</p></div><div><h3>Objective</h3><p>To measure electric fields magnitude and their effects on neuronal firing rate of hippocampal neurons in freely moving rats, and to establish calibrated computational models of current flow.</p></div><div><h3>Methods</h3><p>Current flow models were calibrated on electric field measures in the motor cortex (n = 2 anesthetized rats) and hippocampus. A Neuropixels 2.0 probe with 384 channels was used in an in-vivo rat model of tES (n = 4 freely moving and 2 urethane anesthetized rats) to detect effects of weak fields on neuronal firing rate. High-density field mapping and computational models verified field intensity (1 V/m in hippocampus per 50 μA of applied skull currents).</p></div><div><h3>Results</h3><p>Electric fields of as low as 0.35 V/m (0.25–0.47) acutely modulated average firing rate in the hippocampus. At these intensities, firing rate effects increased monotonically with electric field intensity at a rate of 11.5 % per V/m (7.2–18.3). For the majority of excitatory neurons, firing increased for soma-depolarizing stimulation and diminished for soma-hyperpolarizing stimulation. While more diverse, the response of inhibitory neurons followed a similar pattern on average, likely as a result of excitatory drive.</p></div><div><h3>Conclusion</h3><p>In awake animals, electric fields modulate spiking rate above levels previously observed in vitro. Firing rate effects are likely mediated by somatic polarization of pyramidal neurons. We recommend that all future rodent experiments directly measure electric fields to insure rigor and reproducibility.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 561-571"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000652/pdfft?md5=8e6a4059e976008e9e020a797aca6b86&pid=1-s2.0-S1935861X24000652-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson's disease","authors":"Chien-Hung Yeh ,&nbsp;Yifan Xu ,&nbsp;Wenbin Shi ,&nbsp;James J. Fitzgerald ,&nbsp;Alexander L. Green ,&nbsp;Petra Fischer ,&nbsp;Huiling Tan ,&nbsp;Ashwini Oswal","doi":"10.1016/j.brs.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.brs.2024.04.006","url":null,"abstract":"<div><h3>Background</h3><p>Gait impairment has a major impact on quality of life in patients with Parkinson's disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15–30 Hz) may contribute to gait impairment, but the precise dynamics of this oscillatory activity during gait remain unclear. Additionally, auditory cues are known to lead to improvements in gait kinematics in PD. If the neurophysiological mechanisms of this cueing effect were better understood they could be leveraged to treat gait impairments using adaptive Deep Brain Stimulation (aDBS) technologies.</p></div><div><h3>Objective</h3><p>We aimed to characterize the dynamics of subthalamic nucleus (STN) oscillatory activity during stepping movements in PD and to establish the neurophysiological mechanisms by which auditory cues modulate gait.</p></div><div><h3>Methods</h3><p>We studied STN local field potentials (LFPs) in eight PD patients while they performed stepping movements. Hidden Markov Models (HMMs) were used to discover transient states of spectral activity that occurred during stepping with and without auditory cues.</p></div><div><h3>Results</h3><p>The occurrence of low and high β bursts was suppressed during and after auditory cues. This manifested as a decrease in their fractional occupancy and state lifetimes. Interestingly, α transients showed the opposite effect, with fractional occupancy and state lifetimes increasing during and after auditory cues.</p></div><div><h3>Conclusions</h3><p>We show that STN oscillatory activity in the α and β frequency bands are differentially modulated by gait-promoting oscillatory cues. These findings suggest that the enhancement of α rhythms may be an approach for ameliorating gait impairments in PD.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 501-509"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000640/pdfft?md5=736a97618065d4196262b2c3fd007b88&pid=1-s2.0-S1935861X24000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining trauma script exposure with tDCS to alleviate symptoms of posttraumatic stress disorder: A two-arm randomized sham-controlled multicenter trial","authors":"Noémie Eyraud ,&nbsp;Pierre Poupin ,&nbsp;Marc Legrand,&nbsp;Agnès Caille,&nbsp;Anne Sauvaget,&nbsp;Samuel Bulteau,&nbsp;Bénédicte Gohier,&nbsp;Ghina Harika-Germaneau,&nbsp;Dominique Drapier,&nbsp;Nematollah Jaafari,&nbsp;Olivier Bodic,&nbsp;Bruno Brizard,&nbsp;Valérie Gissot,&nbsp;Catherine Belzung,&nbsp;Jean-Baptiste Courtine,&nbsp;Wissam El-Hage","doi":"10.1016/j.brs.2024.04.018","DOIUrl":"https://doi.org/10.1016/j.brs.2024.04.018","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 591-593"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000809/pdfft?md5=6a5a93977947f47c301a29341e1de906&pid=1-s2.0-S1935861X24000809-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140825527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained reduction of essential tremor with low-power non-thermal transcranial focused ultrasound stimulations in humans","authors":"Thomas Bancel ,&nbsp;Benoît Béranger ,&nbsp;Maxime Daniel ,&nbsp;Mélanie Didier ,&nbsp;Mathieu Santin ,&nbsp;Itay Rachmilevitch ,&nbsp;Yeruham Shapira ,&nbsp;Mickael Tanter ,&nbsp;Eric Bardinet ,&nbsp;Sara Fernandez Vidal ,&nbsp;David Attali ,&nbsp;Cécile Galléa ,&nbsp;Alexandre Dizeux ,&nbsp;Marie Vidailhet ,&nbsp;Stéphane Lehéricy ,&nbsp;David Grabli ,&nbsp;Nadya Pyatigorskaya ,&nbsp;Carine Karachi ,&nbsp;Elodie Hainque ,&nbsp;Jean-François Aubry","doi":"10.1016/j.brs.2024.05.003","DOIUrl":"10.1016/j.brs.2024.05.003","url":null,"abstract":"<div><h3>Background</h3><p>Transcranial ultrasound stimulation (TUS) is a non-invasive brain stimulation technique; when skull aberrations are compensated for, this technique allows, with millimetric accuracy, circumvention of the invasive surgical procedure associated with deep brain stimulation (DBS) and the limited spatial specificity of transcranial magnetic stimulation.</p></div><div><h3>Objective</h3><p>/hypothesis: We hypothesize that MR-guided low-power TUS can induce a sustained decrease of tremor power in patients suffering from medically refractive essential tremor.</p></div><div><h3>Methods</h3><p>The dominant hand only was targeted, and two anatomical sites were sonicated in this exploratory study: the ventral intermediate nucleus of the thalamus (VIM) and the dentato-rubro-thalamic tract (DRT). Patients (N = 9) were equipped with MR-compatible accelerometers attached to their hands to monitor their tremor in real-time during TUS.</p></div><div><h3>Results</h3><p>VIM neurostimulations followed by a low-duty cycle (5 %) DRT stimulation induced a substantial decrease in the tremor power in four patients, with a minimum of 89.9 % reduction when compared with the baseline power a few minutes after the DRT stimulation. The only patient stimulated in the VIM only and with a low duty cycle (5 %) also experienced a sustained reduction of the tremor (up to 93.4 %). Four patients (N = 4) did not respond. The temperature at target was 37.2 ± 1.4 °C compared to 36.8 ± 1.4 °C for a 3 cm away control point.</p></div><div><h3>Conclusions</h3><p>MR-guided low power TUS can induce a substantial and sustained decrease of tremor power. Follow-up studies need to be conducted to reproduce the effect and better to understand the variability of the response amongst patients. MR thermometry during neurostimulations showed no significant thermal rise, supporting a mechanical effect.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 3","pages":"Pages 636-647"},"PeriodicalIF":7.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000858/pdfft?md5=a8567af6f6e82ab8fd5e4427a057c77a&pid=1-s2.0-S1935861X24000858-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140907760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}