Brain Stimulation最新文献

{"title":"Long-term outcomes of vagus nerve stimulation in children with drug resistant epilepsy are driven by early benefit","authors":"Karim Mithani , Farbod Niazi , Hosni Abu Alhasan , Hrishikesh Suresh , Leeor Yefet , Ivanna Yau , Lyndsey McRae , James T. Rutka , Ayako Ochi , Hiroshi Otsubo , Elizabeth Donner , Vann Chau , Puneet Jain , George M. Ibrahim","doi":"10.1016/j.brs.2025.02.010","DOIUrl":"10.1016/j.brs.2025.02.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 246-248"},"PeriodicalIF":7.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of high-dose and personalized TBS on post-stroke cognitive impairment: A randomized controlled trial","authors":"Jianxun Ren ,&nbsp;Wenlong Su ,&nbsp;Ying Zhou ,&nbsp;Kaiyue Han ,&nbsp;Ruiqi Pan ,&nbsp;Xinyu Duan ,&nbsp;Jiajie Liu ,&nbsp;Haitao Lu ,&nbsp;Ping Zhang ,&nbsp;Wei Zhang ,&nbsp;Jian Sun ,&nbsp;Mengying Ding ,&nbsp;Yafei Zhu ,&nbsp;Wuxiang Xie ,&nbsp;Jianting Huang ,&nbsp;Hao Zhang ,&nbsp;Hesheng Liu","doi":"10.1016/j.brs.2025.02.009","DOIUrl":"10.1016/j.brs.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairments are prevalent among stroke patients, impacting independent living. While intermittent theta burst stimulation (iTBS) shows potential for rehabilitation, the efficacy of the commonly-used doses remains unsatisfactory.</div></div><div><h3>Objective</h3><div>To investigate the efficacy, dose-dependent effect, and safety of high-dose iTBS targeting the individualized frontoparietal cognitive network (FCN) for post-stroke cognitive recovery.</div></div><div><h3>Methods</h3><div>In a randomized, sham-controlled, three-arm trial, patients with post-stroke cognitive impairment (PSCI) received 15 days of high-dose (3600 pulses/day), standard low-dose (1200 pulses/day) as an active control, or sham iTBS targeting the individualized FCN, alongside cognitive training. Primary outcome measured changes in global cognition via the Montreal Cognitive Assessment (MoCA). Secondary measures included MoCA response rates and score changes in the Wechsler Memory Scale, Wechsler Adult Intelligence Scale, and Mini-Mental State Examination.</div></div><div><h3>Results</h3><div>Of forty-five randomized participants, forty-one (8 women; mean [SD] age, 58.63 [8.64] years) were analyzed. Personalized targeting improved focality by 33.0 % over the standard F3 target in E-field analysis. Both high-dose and standard low-dose groups showed significant improvements in MoCA. Importantly, the high-dose group demonstrated superior cognitive recovery over both the active control group (estimated difference = 2.50, <em>p</em> = 0.0339, 95 % CI = 0.15–4.84) and the sham control group (estimated difference = 4.29, <em>p</em> = 0.0001, 95 % CI = 1.99–6.60), indicating a superior effect of high-dose stimulation for cognitive recovery. Similar high-dose and dose-dependent effects were observed in other secondary outcomes, suggesting consistent effects on the memory, intelligence, and mental state. No serious adverse events occurred.</div></div><div><h3>Conclusions</h3><div>This study highlights the efficacy and safety of high-dose iTBS targeting the individualized FCN for post-stroke cognitive recovery.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 249-258"},"PeriodicalIF":7.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Low-intensity focused ultrasound (LIFU) for the treatment of post-traumatic headache (PTH) in veterans: A feasibility study” [Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, vol. 17 (2024), pg. 1290–1292/No. 6]","authors":"Byung C. Yoon ,&nbsp;John P. Coetzee ,&nbsp;Xiaojian Kang ,&nbsp;Rajenpreet Brar ,&nbsp;Molly Timmerman ,&nbsp;Odette Harris ,&nbsp;Esmeralda Madrigal ,&nbsp;Maheen M. Adamson","doi":"10.1016/j.brs.2025.01.019","DOIUrl":"10.1016/j.brs.2025.01.019","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Page 211"},"PeriodicalIF":7.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the hemodynamic response to iTBS of the left DLPFC: A concurrent iTBS/fNIRS study","authors":"Adam W.L. Xia ,&nbsp;Minxia Jin ,&nbsp;Bella B.B. Zhang ,&nbsp;Rebecca L.D. Kan ,&nbsp;Tim T.Z. Lin ,&nbsp;Penny P. Qin ,&nbsp;Xiao Wang ,&nbsp;Wanda M.W. Chau ,&nbsp;Nancy M.X.Y. Shi ,&nbsp;Priya Kannan ,&nbsp;Erin Y. Lu ,&nbsp;Tifei Yuan ,&nbsp;Jack Jiaqi Zhang ,&nbsp;Georg S. Kranz","doi":"10.1016/j.brs.2025.02.008","DOIUrl":"10.1016/j.brs.2025.02.008","url":null,"abstract":"<div><h3>Background</h3><div>Intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) is an established treatment regimen for major depressive disorder, but its instantaneous effects on neural excitability during and immediately after the stimulation remain unclear. This study aimed to investigate the hemodynamic response in the bilateral DLPFC during and immediately after iTBS and explored factors that may modulate iTBS-induced excitability.</div></div><div><h3>Methods</h3><div>We measured the prefrontal hemodynamic response before, during, and after iTBS using concurrent iTBS/functional near-infrared spectroscopy (fNIRS) in healthy participants across multiple sessions (3–11 visits, ≥48 hours apart). We investigated the moderating effect of several inter- and intra-individual variables. To this end, we analyzed the average change of oxygenated (HbO) and deoxygenated hemoglobin (HbR) in the stimulated and contralateral DLPFC and used generalized linear mixed models (GLMMs) to test for potential moderators.</div></div><div><h3>Results</h3><div>Twenty participants completed 157 concurrent iTBS/fNIRS sessions in total. HbR increased significantly during iTBS (0.247 ± 0.032, <em>p</em> &lt; 0.001) in the stimulated DLPFC, while the contralateral DLPFC showed significant decreases in HbR during (−0.046 ± 0.017, <em>p</em> = 0.024) and after the stimulation (−0.05 ± 0.018, <em>p</em> = 0.015). No significant change in HbO was observed. GLMM revealed that age (β = 0.033, <em>p</em> = 0.004), sex (β = −0.248, <em>p</em> = 0.004), education years (β = −0.094, <em>p</em> &lt; 0.001), the personality trait agreeableness (β = −0.013, <em>p</em> = 0.005), and positive affect (β = −0.032, <em>p</em> = 0.012) significantly influenced local HbR response during iTBS, and sex (β = 0.305, <em>p</em> = 0.012) significantly influenced local HbO response during iTBS.</div></div><div><h3>Conclusion</h3><div>This study revealed a pronounced increase in HbR during iTBS in the stimulated DLPFC, alongside decreased HbR contralaterally both during and post-stimulation. Furthermore, our study highlights the importance of individual factors in understanding iTBS effects on cortical excitability.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 235-245"},"PeriodicalIF":7.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of HD-tDCS on temporal discounting behavior: An ERP evidence","authors":"Jingzhen He ,&nbsp;Shuangyu Gou ,&nbsp;Jia Shi ,&nbsp;Yawei Qi ,&nbsp;Shaoyu Tu ,&nbsp;Qinghua He","doi":"10.1016/j.brs.2025.02.006","DOIUrl":"10.1016/j.brs.2025.02.006","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 212-214"},"PeriodicalIF":7.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locating activation sites of TMS with opposite current directions using probabilistic modelling and biophysical axon models","authors":"Ilkka Laakso ,&nbsp;Juhani Kataja ,&nbsp;Noora Matilainen ,&nbsp;Timo Roine ,&nbsp;Thomas Tarnaud ,&nbsp;Yoshikazu Ugawa","doi":"10.1016/j.brs.2025.02.003","DOIUrl":"10.1016/j.brs.2025.02.003","url":null,"abstract":"<div><h3>Background:</h3><div>Motor responses evoked by transcranial magnetic stimulation (TMS) using posterior–anterior (PA) and anterior–posterior (AP) current directions have distinct latencies and thresholds. However, the underlying reasons for these differences remain unclear.</div></div><div><h3>Objective:</h3><div>To quantify the differences in activation sites between PA- and AP-TMS.</div></div><div><h3>Methods:</h3><div>Motor evoked potentials (MEPs) were recorded from five hand and arm muscles in nine healthy participants using both PA- and AP-TMS. Active motor thresholds were determined at 11 magnetic coil positions on the scalp. Probabilistic modelling was used to combine the measured threshold data with calculated electric field data from individual MRI-based models. This approach constructed 70 probability distributions of the activation site, dependent on the muscle and TMS direction.</div></div><div><h3>Results:</h3><div>Modelling indicated that both PA- and AP-TMS more likely activated structures in white matter than in grey matter. PA-TMS activation sites were primarily in the white or grey matter in the precentral gyrus, while the AP-TMS activations were deeper and more posterior and lateral, likely within white matter under the postcentral and/or precentral gyri. Tractography and biophysical axon models provided a potential explanation on the location of activation sites: AP-TMS may activate the bends of white matter axons farther from M1 than PA-TMS, such that the conduction velocity along the neural tract could potentially explain the longer MEP latency of AP-TMS. The differences in activation sites among the five hand and arm muscles were small.</div></div><div><h3>Conclusion:</h3><div>While a direct experimental confirmation of the activation sites is still needed, the results suggest that electric field analysis combined with tractography and biophysical axon modelling could be a useful computational tool for analysing and optimizing TMS.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 215-224"},"PeriodicalIF":7.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling the local extracellular electric field can suppress the generation and propagation of seizures and spikes in the hippocampus","authors":"Muthumeenakshi Subramanian,&nbsp;Chia-Chu Chiang,&nbsp;Cedric Levi,&nbsp;Dominique M. Durand","doi":"10.1016/j.brs.2025.02.001","DOIUrl":"10.1016/j.brs.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>Neural activity such as theta waves, epileptic spikes and seizures can cross a physical transection using electric fields thus propagating by ephaptic coupling and independently of synaptic transmission. Recruitment of neurons in epilepsy occurs in part due to electric field coupling in addition to synaptic mechanisms. Hence, controlling the local electric field could suppress or cancel the generation of these epileptic events.</div></div><div><h3>Methods</h3><div>4-aminopyridine (4-AP) was used to induce spontaneous epileptic spikes and seizures in longitudinal hippocampal slices in-vitro. Two extracellular recording electrodes were placed in the tissue, one at the edge of the slice on the temporal side at the focus of the epileptic activity and the other on the septal side to record the propagation. Two stimulating electrodes were placed outside the slice at the edge of the focal zone. An extracellular voltage clamp circuit maintained the voltage within the focus at 0V with respect to the bath ground.</div></div><div><h3>Results</h3><div>Experiments showed that 100 % of the epileptic activity originated at the temporal region and propagated to the septal region of the slices thereby establishing the existence of a focus in the temporal end of the tissue. The clamp achieved 100 % suppression of all seizure activity in the tissue with current amplitudes between 70 and 250 nA. No spikes or seizures were observed in either the focus or the septal region when the clamp was “on”. When the clamp was turned off, both the spikes and seizure events recovered immediately.</div></div><div><h3>Conclusions</h3><div>The experiments show that controlling the extracellular voltage within a focus can prevent the generation and the propagation of epileptiform activity from the focus with very low amplitudes currents.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 225-234"},"PeriodicalIF":7.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing accelerated iTBS in treatment-resistant melancholic depression: Doubling the number of pulses per session does not double the response rates","authors":"S. De Witte ,&nbsp;R. De Raedt ,&nbsp;Gr Wu ,&nbsp;S. De Smet ,&nbsp;J. Dedoncker ,&nbsp;D. Klooster ,&nbsp;H. Tandt ,&nbsp;N. Van De Velde ,&nbsp;N. De Schrijver ,&nbsp;S. Herremans ,&nbsp;I. Debruyckere ,&nbsp;A. Nobels ,&nbsp;E.H.W. Koster ,&nbsp;G. Lemmens ,&nbsp;M.A. Vanderhasselt ,&nbsp;C. Baeken","doi":"10.1016/j.brs.2025.02.004","DOIUrl":"10.1016/j.brs.2025.02.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 195-197"},"PeriodicalIF":7.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia","authors":"Noreen Bukhari-Parlakturk ,&nbsp;Patrick J. Mulcahey ,&nbsp;Michael W. Lutz ,&nbsp;Rabia Ghazi ,&nbsp;Ziping Huang ,&nbsp;Moritz Dannhauer ,&nbsp;Pichet Termsarasab ,&nbsp;Burton Scott ,&nbsp;Zeynep B. Simsek ,&nbsp;Skylar Groves ,&nbsp;Mikaela Lipp ,&nbsp;Michael Fei ,&nbsp;Tiffany K. Tran ,&nbsp;Eleanor Wood ,&nbsp;Lysianne Beynel ,&nbsp;Chris Petty ,&nbsp;James T. Voyvodic ,&nbsp;Lawrence G. Appelbaum ,&nbsp;Hussein R. Al-Khalidi ,&nbsp;Simon W. Davis ,&nbsp;Nicole Calakos","doi":"10.1016/j.brs.2025.02.005","DOIUrl":"10.1016/j.brs.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Writer's cramp (WC) dystonia is an involuntary movement disorder with distributed abnormalities in the brain's motor network. Prior studies established the potential for repetitive transcranial magnetic stimulation (rTMS) to either premotor cortex (PMC) or primary somatosensory cortex (PSC) to modify symptoms. However, clinical effects have been modest with limited understanding of the neural mechanisms hindering therapeutic advancement of this promising approach.</div></div><div><h3>Objective</h3><div>This study aimed to understand the motor network effects of rTMS in WC that correspond with behavioral efficacy. We hypothesized that behavioral efficacy is associated with modulation of cortical and subcortical regions of the motor network.</div></div><div><h3>Methods</h3><div>In a double-blind, cross-over design, twelve WC participants underwent rTMS in one of three conditions (Sham-TMS, 10 Hz PSC-rTMS, 10 Hz PMC-rTMS) while engaged in a writing task to activate dystonic movements and measure writing fluency. Brain connectivity was evaluated using task-based fMRI after each TMS session.</div></div><div><h3>Results</h3><div>10 Hz rTMS to PSC, but not PMC, significantly improved writing dysfluency. PSC-TMS also significantly weakened cortico-basal ganglia, cortico-cerebellum, and intra-cerebellum functional connectivity (FC), and strengthened striatal FC relative to Sham. Change in PSC and SPC BOLD activity were associated with reduced dysfluent writing behavior.</div></div><div><h3>Conclusions</h3><div>10 Hz rTMS to PSC improved writing dysfluency by redistributing motor network connectivity and strengthening somatosensory-parietal connectivity. A key signature for effective stimulation at PSC and improvement in writing dysfluency may be strengthening of intra-cortical connectivity between primary somatosensory and superior parietal cortices. These findings offer mechanistic hypotheses to advance the therapeutic application of TMS for dystonia.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 198-210"},"PeriodicalIF":7.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal forebrain activation improves working memory in senescent monkeys","authors":"Kendyl R. Pennington ,&nbsp;Luca Debs ,&nbsp;Sophia Chung ,&nbsp;Janki Bava ,&nbsp;Clément M. Garin ,&nbsp;Fernando L. Vale ,&nbsp;Sarah K. Bick ,&nbsp;Dario J. Englot ,&nbsp;Alvin V. Terry Jr. ,&nbsp;Christos Constantinidis ,&nbsp;David T. Blake","doi":"10.1016/j.brs.2025.02.002","DOIUrl":"10.1016/j.brs.2025.02.002","url":null,"abstract":"<div><div>Brain aging contributes to cognitive decline and risk of dementia. Degeneration of the basal forebrain cholinergic system parallels these changes in aging, Alzheimer's dementia, Parkinson's dementia, and Lewy body dementia, and thus is a common element linked to executive function across the lifespan and in disease states. Here, we tested the potential of one-hour daily intermittent basal forebrain stimulation to improve cognition in senescent Rhesus monkeys, and its mechanisms of action. Stimulation in five animals improved working memory duration in each animal over 8–12 weeks, with peak improvements observed in the first four weeks. In an ensuing three month period without stimulation, improvements were retained. With additional stimulation, performance remained above baseline throughout the 15 months of the study. Studies with a cholinesterase inhibitor in five animals produced inconsistent improvements in behavior. One of five animals improved significantly. Manipulating the stimulation pattern demonstrated selectivity for both stimulation and recovery period duration in two animals. Brain stimulation led to acute increases in cerebrospinal fluid levels of tissue plasminogen activator, which is an activating element for two brain neurotrophins, Nerve Growth Factor (NGF) and Brain-Derived Growth Factor (BDNF), in four animals. Stimulation also led to improved glucose utilization in stimulated hemispheres relative to contralateral in three animals. Glucose utilization also consistently declines with aging and some dementias. Together, these findings suggest that intermittent stimulation of the nucleus basalis of Meynert improves executive function and reverses some aspects of brain aging.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 185-194"},"PeriodicalIF":7.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}