Brain Stimulation最新文献

{"title":"Transcranial focused ultrasound stimulation enhances cerebrospinal fluid movement: Real-time in vivo two-photon and widefield imaging evidence","authors":"Seunghwan Choi ,&nbsp;Jeungeun Kum ,&nbsp;Seon Young Hyun ,&nbsp;Tae Young Park ,&nbsp;Hyungmin Kim ,&nbsp;Sun Kwang Kim ,&nbsp;Jaeho Kim","doi":"10.1016/j.brs.2024.09.006","DOIUrl":"10.1016/j.brs.2024.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Cerebrospinal fluid (CSF) flow is crucial for brain homeostasis and its dysfunction is highly associated with neurodegenerative diseases. Restoring CSF circulation is proposed as a key strategy for the treatment of the diseases. Among the methods to improve CSF circulation, focused ultrasound (FUS) stimulation has emerged as a promising non-invasive brain stimulation technique, with effectiveness evidenced by <em>ex vivo</em> studies. However, due to technical disturbances in <em>in vivo</em> imaging combined with FUS, direct evidence of real-time <em>in vivo</em> CSF flow enhancement by FUS remains elusive.</p></div><div><h3>Objective</h3><p>To investigate whether FUS administered through the skull base can enhance CSF influx in living animals with various real-time imaging techniques.</p></div><div><h3>Methods</h3><p>We demonstrate a novel method of applying FUS through the skull base, facilitating cortical CSF influx, evidenced by diverse <em>in vivo</em> imaging techniques. Acoustic simulation confirmed effective sonication of our approach through the skull base. After injecting fluorescent CSF tracers into cisterna magna, FUS was administered at the midline of the jaw through the skull base for 30 min, during which imaging was performed concurrently.</p></div><div><h3>Results</h3><p>Enhanced CSF influx was observed in macroscopic imaging, demonstrated by the influx area and intensity of the fluorescent dyes after FUS. In two-photon imaging, increased fluorescence was observed in the perivascular space (PVS) after stimulation. Moreover, particle tracking of microspheres showed more microspheres entering the imaging field, with increased mean speed after FUS.</p></div><div><h3>Conclusion</h3><p>Our findings provide direct real-time <em>in vivo</em> imaging evidence that FUS promotes CSF influx and flow in the PVS.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1119-1130"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001591/pdfft?md5=f6d68ddbe0c81b92aa048d3ed7c57acf&pid=1-s2.0-S1935861X24001591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial magnetic stimulation-associated heart rate decelerations attenuate after a TMS treatment course for depression","authors":"Alexandra A. Alario,&nbsp;Benjamin D. Pace,&nbsp;Mark J. Niciu,&nbsp;Nicholas T. Trapp","doi":"10.1016/j.brs.2024.09.011","DOIUrl":"10.1016/j.brs.2024.09.011","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1155-1156"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of subject motion during TMS via pulsewise coil displacement","authors":"Ole Numssen,&nbsp;Sandra Martin,&nbsp;Kathleen Williams,&nbsp;Thomas R. Knösche ,&nbsp;Gesa Hartwigsen","doi":"10.1016/j.brs.2024.08.009","DOIUrl":"10.1016/j.brs.2024.08.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1045-1047"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001505/pdfft?md5=b99823776f8ca9c81772c1e2e0cbc079&pid=1-s2.0-S1935861X24001505-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive closed-loop modulation of cortical theta oscillations: Insights into the neural dynamics of navigational decision-making","authors":"Farhad Farkhondeh Tale Navi ,&nbsp;Soomaayeh Heysieattalab ,&nbsp;Mohammad Reza Raoufy ,&nbsp;Saied Sabaghypour ,&nbsp;Milad Nazari ,&nbsp;Mohammad Ali Nazari","doi":"10.1016/j.brs.2024.09.005","DOIUrl":"10.1016/j.brs.2024.09.005","url":null,"abstract":"<div><p>Navigational decision-making tasks, such as spatial working memory (SWM), rely highly on information integration from several cortical and sub-cortical regions. Performance in SWM tasks is associated with theta rhythm, including low-frequency oscillations related to movement and memory. The interaction of the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC), reflected in theta synchrony, is essential in various steps of information processing during SWM. We used a closed-loop neurofeedback (CLNF) system to upregulate theta power in the mPFC and investigate its effects on circuit dynamics and behavior in animal models. Specifically, we hypothesized that enhancing the power of the theta rhythm in the mPFC might improve SWM performance. Animals were divided into three groups: closed-loop (CL), random-loop (RL), and OFF (without stimulation). We recorded local field potential (LFP) in the mPFC while electrical reward stimulation contingent on cortical theta activity was delivered to the lateral hypothalamus (LH), which is considered one of the central reward-associated regions. We also recorded LFP in the vHPC to evaluate the related subcortical neural changes. Results revealed a sustained increase in the theta power in both mPFC and vHPC for the CL group. Our analysis also revealed an increase in mPFC-vHPC synchronization in the theta range over the stimulation sessions in the CL group, as measured by coherence and cross-correlation in the theta frequency band. The reinforcement of this circuit improved spatial decision-making performance in the subsequent behavioral results. Our findings provide direct evidence of the relationship between specific theta upregulation and SWM performance and suggest that theta oscillations are integral to cognitive processes. Overall, this study highlights the potential of adaptive CLNF systems in investigating neural dynamics in various brain circuits.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1101-1118"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001608/pdfft?md5=e6e386dcb782540ba3a796c365e4d0ff&pid=1-s2.0-S1935861X24001608-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events with concurrent cannabis use during transcranial magnetic stimulation therapy for major depressive disorder: A case series analysis","authors":"Gian M. DePamphilis,&nbsp;Eric Tirrell,&nbsp;E. Frances Kronenberg,&nbsp;Joshua C. Brown,&nbsp;Andrew M. Fukuda,&nbsp;Linda L. Carpenter","doi":"10.1016/j.brs.2024.09.008","DOIUrl":"10.1016/j.brs.2024.09.008","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1140-1141"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001633/pdfft?md5=b2f9c77ff9b9651345e73fdfafef0420&pid=1-s2.0-S1935861X24001633-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetra codes: A precise, concise notation system for scalp-based neuronavigation","authors":"Yiru Li,&nbsp;Angel V. Peterchev,&nbsp;Jonathan Downar","doi":"10.1016/j.brs.2024.09.012","DOIUrl":"10.1016/j.brs.2024.09.012","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1142-1144"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory study of short-term treatment with adaptive neurostimulation in children with drug-resistant epilepsy","authors":"Tinghong Liu ,&nbsp;Hanlei Li ,&nbsp;Suhui Kuang ,&nbsp;Liu Yuan,&nbsp;Weixing Feng,&nbsp;Hua Li,&nbsp;Ping Ding,&nbsp;Zhirong Wei,&nbsp;Shuli Liang","doi":"10.1016/j.brs.2024.09.013","DOIUrl":"10.1016/j.brs.2024.09.013","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1167-1169"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction and stabilization of delta frequency brain oscillations by phase-synchronized rTMS and tACS","authors":"Kuri Takahashi ,&nbsp;Benedikt Glinski ,&nbsp;Mohammed Ali Salehinejad ,&nbsp;Asif Jamil ,&nbsp;Acer Yu-Chan Chang ,&nbsp;Min-Fang Kuo ,&nbsp;Michael A. Nitsche","doi":"10.1016/j.brs.2024.09.003","DOIUrl":"10.1016/j.brs.2024.09.003","url":null,"abstract":"<div><h3>Background</h3><p>Brain oscillations in the delta frequency band have been linked with deep sleep and consolidation of declarative memory during sleep. However, the causal relationship of these associations remains not competely clarified, primarily due to constraints by technical limitations of brain stimulation approaches suited to induce and stabilize respective oscillatory activity in the human brain. The objective of this study was to establish a non-invasive brain stimulation protocol capable of reliably inducing, and stabilizing respective oscillatory activity in the delta frequency range.</p></div><div><h3>Hypothesis</h3><p>We aimed to develop an efficient non-invasive brain stimulation (NIBS) protocol for delta frequency induction and stabilization via concurrent, phase-locked repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS). We hypothesized that rTMS induces oscillatory resting-state activity in the delta frequency and that tACS stabilizes this effect, as has been shown before for alpha and theta frequencies.</p></div><div><h3>Methods</h3><p>19 healthy participants took part in a repeated-measures experimental protocol. We applied rTMS pulses synchronized with the peak or trough phase of 0.75Hz tACS over the bilateral prefrontal cortex. Resting state EEG in eyes-open (EO) and eyes-closed (EC) conditions was recorded before, immediately after and every 10 min for up to 1 h after intervention.</p></div><div><h3>Results</h3><p>rTMS phase-synchronized to the trough of the tACS waveform significantly increased delta frequency activity for up to 60 min in both EO and EC conditions after stimulation. The effects extended from frontal to temporal regions and this enhancement of oscillatory activity was shown to be specific for the delta frequency range.</p></div><div><h3>Conclusion</h3><p>Concurrent, trough-synchronized 0.75 Hz rTMS combined with tACS may be a reliable protocol to induce long-lasting oscillatory activity in the delta frequency range. The results of the current study might perspectively be relevant for clinical treatment of sleep disturbances which are accompanied by pathologically altered brain oscillations, and enhancement of memory consolidation.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1086-1097"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001578/pdfft?md5=d45c2d39befc51eb1228e15eb4daccfd&pid=1-s2.0-S1935861X24001578-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-cardiac coupling predicts heart rate regulation effects of neuro-cardiac-guided transcranial magnetic stimulation (TMS)","authors":"Chen Cheng ,&nbsp;Yunyun Jiao ,&nbsp;Mengnan Jia,&nbsp;Jiajie Jin,&nbsp;Xiangmiao Peng,&nbsp;Mengkai Zhang,&nbsp;Xiaoyu Song,&nbsp;Zhaoyang Chu,&nbsp;Xiao Zeng,&nbsp;Jin-Bo Sun,&nbsp;Xue-Juan Yang,&nbsp;Wei Qin","doi":"10.1016/j.brs.2024.09.007","DOIUrl":"10.1016/j.brs.2024.09.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1134-1136"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X2400161X/pdfft?md5=644d14c441d93f09811897ce5a6fb61d&pid=1-s2.0-S1935861X2400161X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early symptom improvement as a predictor of TMS treatment outcomes in posttraumatic stress disorder","authors":"Miriam A. Goldberg,&nbsp;Michelle R. Madore,&nbsp;F. Andrew Kozel,&nbsp;Noah S. Philip,&nbsp;Yosef A. Berlow","doi":"10.1016/j.brs.2024.09.009","DOIUrl":"10.1016/j.brs.2024.09.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1137-1139"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001621/pdfft?md5=da7399a970c9374e6210bee03e4f9d57&pid=1-s2.0-S1935861X24001621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}