Brain Stimulation最新文献_第7页

Lesion in the path of current flow to target pericavitational and perilesional brain areas: Acute network-level tDCS findings in chronic aphasia using concurrent tDCS/fMRI 脑空泡周围和病灶周围电流路径上的病变：并发tDCS/fMRI在慢性失语症中的急性网络水平tDCS表现。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-30 DOI: 10.1016/j.brs.2025.01.024

Venkatagiri Krishnamurthy , Serena E. Song , Lisa C. Krishnamurthy , Simone Renée Roberts , Joo H. Han , Amy D. Rodriguez , Samir R. Belagaje , Marcus Meinzer , Bruce A. Crosson

引用次数: 0

Vagal nerve stimulation dynamically alters anxiety-like behavior in rats 迷走神经刺激动态改变大鼠的焦虑样行为。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-30 DOI: 10.1016/j.brs.2025.01.018

A.G. Butler , J.K. Bassi , A.A. Connelly , M.R. Melo , A.M. Allen , S.J. McDougall

{"title":"Vagal nerve stimulation dynamically alters anxiety-like behavior in rats","authors":"A.G. Butler , J.K. Bassi , A.A. Connelly , M.R. Melo , A.M. Allen , S.J. McDougall","doi":"10.1016/j.brs.2025.01.018","DOIUrl":"10.1016/j.brs.2025.01.018","url":null,"abstract":"<div><h3>Background</h3><div>Electrical vagal nerve stimulation (VNS), at currents designed to target sensory, interoceptive neurons, decreases anxiety-like behavior.</div></div><div><h3>Objective/Hypothesis</h3><div>We hypothesized that different VNS current intensities would differentially alter anxiety-like behavior through the activation of distinct brainstem circuits.</div></div><div><h3>Methods</h3><div>Electrodes were implanted to stimulate the left vagus nerve and to record diaphragm muscle and electrocardiogram activity. The VNS current required to elicit the A-fiber-mediated Hering-Breuer Reflex (HBR) was determined for each animal. Based on this threshold, animals received either sham stimulation or VNS at 1.5 (mid-intensity VNS) or 3 (higher-intensity VNS) times the threshold for HBR activation. Anxiety-like behavior was assessed using the elevated plus maze, open field test, and novelty-suppressed feeding test. Additionally, a place preference assay determined whether VNS is rewarding or aversive. Finally, a c-Fos assay was performed to evaluate VNS-driven neuronal activation within the brainstem.</div></div><div><h3>Results</h3><div>Mid-intensity VNS reduced anxiety-like behavior in the elevated plus maze and open field test. Higher-intensity VNS was aversive during the place preference assay, confounding anxiety measures. Both intensities increased overall c-Fos expression in neurons within the nucleus of the solitary tract, but mid-intensity VNS specifically increased c-Fos expression in noradrenergic neurons within the nucleus of the solitary tract while decreasing it in the locus coeruleus. In contrast, higher-intensity VNS had no effect on c-Fos expression in noradrenergic neurons of either the nucleus of the solitary tract or locus coeruleus.</div></div><div><h3>Conclusion</h3><div>Delivery of VNS induced reproducible, current intensity-dependent, effects on anxiety-like and aversive behavior in rats.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 158-170"},"PeriodicalIF":7.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis 经皮耳迷走神经刺激能改变瞳孔扩张吗？一个活生生的贝叶斯元分析。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-28 DOI: 10.1016/j.brs.2025.01.022

Ipek Pervaz , Lilly Thurn , Cecilia Vezzani , Luisa Kaluza , Anne Kühnel , Nils B. Kroemer

{"title":"Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis","authors":"Ipek Pervaz , Lilly Thurn , Cecilia Vezzani , Luisa Kaluza , Anne Kühnel , Nils B. Kroemer","doi":"10.1016/j.brs.2025.01.022","DOIUrl":"10.1016/j.brs.2025.01.022","url":null,"abstract":"<div><h3>Background</h3><div>Transcutaneous vagus nerve stimulation (tVNS) has emerged as a promising technique to modulate autonomic functions, and pupil dilation has been recognized as a promising biomarker for tVNS-induced monoaminergic release. Nevertheless, studies on the effectiveness of various tVNS protocols have produced heterogeneous results on pupil dilation to date.</div></div><div><h3>Methods</h3><div>Here, we synthesize the existing evidence and compare conventional (“continuous”) and pulsed stimulation protocols using a Bayesian meta-analysis. To maintain a living version, we developed a Shiny App with the possibility to incorporate newly published studies in the future. Based on a systematic review, we included 18 studies (N = 771) applying either conventional or pulsed stimulation protocols.</div></div><div><h3>Results</h3><div>Across studies, we found anecdotal evidence for the null hypothesis, showing that taVNS does not increase pupil size (<em>g</em> = 0.15, 95 % CI = [0.03, 0.27], BF<sub>01</sub> = 1.0). Separating studies according to conventional vs. pulsed protocols revealed that studies using pulsed taVNS provide strong evidence for the alternative hypothesis(<em>g</em> = 0.36, 95 % CI = [0.19, 0.53], BF<sub>10</sub> = 50.8) while conventional taVNS studies provide strong evidence for the null hypothesis (<em>g</em> = 0.002, CI = [-0.14, 0.14], BF<sub>01</sub> = 21.9).</div></div><div><h3>Conclusion</h3><div>Our meta-analysis highlights differential effects of conventional and pulsed taVNS protocols on pupil dilation. These findings underscore the relevance of taVNS protocols in optimizing its use for specific applications that may require modulation of tonic vs. phasic monoaminergic responses and might also help to gain mechanistic insights into potential therapeutic effects.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 148-157"},"PeriodicalIF":7.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of pulse amplitude in electroconvulsive therapy on seizure threshold, seizure duration, and time to reorientation 电休克治疗中脉冲振幅对癫痫阈值、癫痫持续时间和重新定向时间的影响。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-28 DOI: 10.1016/j.brs.2025.01.023

Maya Hazimeh , Harold A. Sackeim , Ziad Nahas

引用次数: 0

Bayesian Optimization Of NeuroStimulation (BOONStim) 神经刺激贝叶斯优化（BOONStim）。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-27 DOI: 10.1016/j.brs.2025.01.020

Lindsay D. Oliver , Jerrold Jeyachandra , Erin W. Dickie , Colin Hawco , Salim Mansour , Stephanie M. Hare , Robert W. Buchanan , Anil K. Malhotra , Daniel M. Blumberger , Zhi-De Deng , Aristotle N. Voineskos

引用次数: 0

High intensity transcranial altering current stimulation for cognitive dysfunction in schizophrenia: A pilot trial 高强度经颅改变电流刺激治疗精神分裂症患者的认知功能障碍：一项试点试验。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-27 DOI: 10.1016/j.brs.2025.01.021

Zifan You , Zhangyin He , Luyao Zou , Shanshan Chen , Jinsong Tang

引用次数: 0

Influence of coil orientation on the TMS-induced electric field within the clinically recommended brain region for major depressive disorder 线圈方向对重度抑郁症临床推荐脑区tms诱发电场的影响。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-26 DOI: 10.1016/j.brs.2025.01.017

JianKang Wu , He Wang , Jingna Jin , Xin Wang , Ying Li , Zhipeng Liu , Tao Yin

引用次数: 0

Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease 脑深部刺激治疗酒精使用障碍和酒精性肝病的成本-效果分析。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-24 DOI: 10.1016/j.brs.2025.01.014

Oluwatofunmi A. Abiola , Collin M. Lehmann , Khaled Moussawi , Hawre Jalal

{"title":"Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease","authors":"Oluwatofunmi A. Abiola , Collin M. Lehmann , Khaled Moussawi , Hawre Jalal","doi":"10.1016/j.brs.2025.01.014","DOIUrl":"10.1016/j.brs.2025.01.014","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use disorder (AUD) is a major public health concern and cause of mortality and morbidity. Alcohol-associated liver disease (ALD) is a debilitating complication of AUD, mitigated by abstinence from alcohol use. Deep brain stimulation (DBS) is emerging as a potential treatment for AUD. However, its cost-effectiveness compared to the standard medical treatment is unclear.</div></div><div><h3>Objective</h3><div>To estimate the cost-effectiveness of DBS compared to medical management for patients with AUD and ALD.</div></div><div><h3>Methods</h3><div>We utilized a decision analytic model based on published literature to conduct a cost-effectiveness analysis of costs and health outcomes for DBS and medical management in patients with AUD and ALD. We also carried out a threshold analysis to determine the probability of success necessary for DBS to be cost-effective. Costs were measured in 2024 US dollars and effectiveness in quality-adjusted life years (QALYs). We used a time horizon of 1–2 years and adopted a societal perspective.</div></div><div><h3>Results</h3><div>Our results show that for AUD patients in general, DBS is not cost-effective at any DBS success rate. However, for advanced ALD patients, defined as fibrosis stage 3 or beyond DBS becomes cost-effective. For these patients, DBS is cost-effective over a two-year period at a $100,000 willingness-to-pay threshold at DBS success rates greater than 53 %. For advanced decompensated ALD patients, DBS is cost-effective over a one-year period at DBS success rate greater than 35 %.</div></div><div><h3>Conclusion</h3><div>Should it prove efficacious, DBS may be cost-effective for patients with AUD and ALD. Thus, future randomized controlled trials to evaluate its efficacy are warranted.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 122-131"},"PeriodicalIF":7.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Note of concern regarding the sources of scientific evidence used to justify the Reclassification of Non-Invasive Brain Stimulation (NIBS) Devices without an intended medical purpose into Class III 关于将无预期医疗目的的非侵入性脑刺激（NIBS）设备重新分类为III类的科学证据来源的关注说明。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-21 DOI: 10.1016/j.brs.2025.01.012

Andrea Antal , Alexander T. Sack , Til Ole Bergmann , Jovana Bjekic , Saša R. Filipovic , Ana Ganho-Ávila , Vera Moliadze , Michael A. Nitsche , Simone Rossi , Teresa Schuhmann , Hartwig Siebner , Walter Paulus , Chris Baeken

引用次数: 0

The ENIGMA-Neuromodulation working group – A mission statement enigma -神经调节工作组-使命声明。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-01-10 DOI: 10.1016/j.brs.2024.12.1477

Taylor P. Kuhn , Aprinda Indahlastari , Fidel Vila-Rodriguez , Gregory A. Fonzo

引用次数: 0