Brain Stimulation最新文献

{"title":"Transcutaneous auricular vagus nerve stimulation accelerates postoperative ileus recovery by enhancing gastric motility complexity: A clinical study","authors":"Chih-Hsu Huang, Chun-Hsien Wu, Ren-Hao Chan, Chian-Hui Chen, Bo-Wen Lin, Chou-Ching K. Lin","doi":"10.1016/j.brs.2025.05.002","DOIUrl":"10.1016/j.brs.2025.05.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1091-1093"},"PeriodicalIF":7.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left inferior parietal lobe and auditory cortex jointly contribute to sound knowledge retrieval","authors":"Philipp Kuhnke ,&nbsp;Ole Numssen ,&nbsp;Johannah Voeller ,&nbsp;Vincent K.M. Cheung ,&nbsp;Konstantin Weise ,&nbsp;Markus Kiefer ,&nbsp;Gesa Hartwigsen","doi":"10.1016/j.brs.2025.05.113","DOIUrl":"10.1016/j.brs.2025.05.113","url":null,"abstract":"<div><h3>Background</h3><div>Conceptual knowledge is central to human cognition. Neuroimaging studies suggest that conceptual processing relies on the joint contribution of modality-specific perceptual-motor and multimodal brain regions. In particular, the multimodal left inferior parietal lobe (IPL) couples with auditory association cortex during sound knowledge retrieval and with somatomotor cortex during action feature retrieval. However, it remains unknown whether the interaction between modality-specific and multimodal cortices is causally relevant for conceptually-guided behavior.</div></div><div><h3>Methods</h3><div>To tackle this issue, we applied offline transcranial magnetic stimulation (TMS) over modality-specific cortex (somatomotor, auditory, or sham), before 24 healthy participants received online TMS over multimodal cortex (IPL, or sham) during action and sound knowledge tasks on written words. For the first time in a TMS study on higher cognition, TMS targeting and dosing were optimized using individual <em>a priori</em> computational electric field simulations.</div></div><div><h3>Results</h3><div>We found that combined stimulation of auditory association cortex and multimodal IPL selectively impaired sound judgments, but not action judgments, on low sound–low action words (BF₁₀ = 5.316). Unifocal TMS over auditory cortex or IPL alone did not disrupt behavior, suggesting adaptive compensatory plasticity.</div></div><div><h3>Conclusions</h3><div>These results indicate that the joint contribution of multimodal IPL and auditory cortex is causally relevant for sound knowledge retrieval: The functional relevance of left IPL depends on the integrity of the auditory cortex, and vice versa, as single perturbation of either region did not disrupt performance. Our findings support “hybrid theories” of conceptual processing, which propose that task-dependent functional interactions between modality-specific and multimodal regions are crucial.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1037-1047"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical artifacts during transcranial focused ultrasound mimic biologically evoked responses","authors":"Duc T Nguyen ,&nbsp;Elisa E Konofagou ,&nbsp;Jacek P Dmochowski","doi":"10.1016/j.brs.2025.05.114","DOIUrl":"10.1016/j.brs.2025.05.114","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1094-1096"},"PeriodicalIF":7.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of transcranial direct-current stimulation as a therapeutic option for the control of cortical tremor in Benign adult familial myoclonic epilepsy","authors":"Chiaki Takahashi ,&nbsp;Takashi Asahi ,&nbsp;Ichiro Takumi ,&nbsp;Isao Matsushita","doi":"10.1016/j.brs.2025.05.112","DOIUrl":"10.1016/j.brs.2025.05.112","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1056-1058"},"PeriodicalIF":7.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of technical data: At-home vs. in-clinic application of transcranial direct current stimulation in depression","authors":"Ulrike Vogelmann ,&nbsp;Matthias Stadler ,&nbsp;Aldo Soldini ,&nbsp;Kai-Yen Chang ,&nbsp;Miaoxi Chen ,&nbsp;Lucia Bulubas ,&nbsp;Esther Dechantsreiter ,&nbsp;Christian Plewnia ,&nbsp;Andreas Fallgatter ,&nbsp;Berthold Langguth ,&nbsp;Claus Normann ,&nbsp;Lukas Frase ,&nbsp;Peter Zwanzger ,&nbsp;Thomas Kammer ,&nbsp;Carlos Schönfeldt-Lecuona ,&nbsp;Daniel Kamp ,&nbsp;Malek Bajbouj ,&nbsp;Alexander Hunold ,&nbsp;Severin Schramm ,&nbsp;Josef Priller ,&nbsp;Frank Padberg","doi":"10.1016/j.brs.2025.05.103","DOIUrl":"10.1016/j.brs.2025.05.103","url":null,"abstract":"<div><h3>Objective</h3><div>The application of transcranial direct current stimulation (tDCS) at home for the treatment of depression and other neuropsychiatric disorders presents both significant opportunities and inherent challenges. Ensuring safety and maintaining high-quality stimulation are paramount for the efficacy and safety of at-home tDCS. This study investigates tDCS quality based on its technical parameters as well as safety of at-home and in-clinic tDCS applications comparing the data from two randomized controlled trials in patients with major depressive disorder.</div></div><div><h3>Methods</h3><div>We analyzed 229 active stimulation sessions from the HomeDC study (at-home tDCS) and 835 sessions from the DepressionDC study (in-clinic tDCS). Notably, five adverse events (skin lesions) were reported exclusively in the at-home cohort, highlighting the critical need for enhanced safety protocols in unsupervised environments.</div></div><div><h3>Results</h3><div>The analysis revealed a significant difference in the average variability of impedances between at-home and in-clinic applications (F1,46 = 4.96, p = .031, η² = .097). The at-home tDCS sessions exhibited higher impedance variability (M = 837, SD = 328) compared to in-clinic sessions (M = 579, SD = 309). Furthermore, at-home tDCS sessions resulting in adverse events (AEs) were associated with significantly higher average impedances than sessions without such issues.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that monitoring the technical parameters of at-home tDCS used in this study is essential. However, it may be not sufficient for ensuring safety and promptly detecting or preventing adverse events. Quality control protocols including digital training and monitoring techniques should be systematically developed and tested for a reliable and safe application of at-home tDCS therapies.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1097-1105"},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One nerve, two Stories: Low- and high-frequency external trigeminal nerve stimulation (eTNS) shape cortical and autonomic sleep dynamics differently","authors":"Chen Cheng ,&nbsp;Xiangmiao Peng ,&nbsp;Yuchen Sun ,&nbsp;Yunyun Jiao ,&nbsp;Xiao Zeng ,&nbsp;Jin-Bo Sun ,&nbsp;Xue-Juan Yang ,&nbsp;Wei Qin","doi":"10.1016/j.brs.2025.05.104","DOIUrl":"10.1016/j.brs.2025.05.104","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1049-1051"},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta-frequency subthalamic nucleus stimulation increases decision threshold","authors":"Rachel C. Cole ,&nbsp;Nadja R. Ging-Jehli ,&nbsp;Juan Vivanco Suarez ,&nbsp;Jeremy D. Greenlee ,&nbsp;Jan R. Wessel ,&nbsp;Arturo I. Espinoza ,&nbsp;Johnson Zhang ,&nbsp;James F. Cavanagh ,&nbsp;Nandakumar S. Narayanan","doi":"10.1016/j.brs.2025.05.105","DOIUrl":"10.1016/j.brs.2025.05.105","url":null,"abstract":"<div><h3>Introduction</h3><div>Executive functions are often impaired in patients with Parkinson's disease (PD), and these deficits can be predicted by decreased frontal cortical 4–8 Hz theta activity that is associated with cognitive control. Previous work has shown that stimulating the subthalamic nucleus (STN) at theta frequencies via deep-brain stimulation (DBS) can improve cognitive control. Here we tested the neurocomputational hypothesis that stimulating STN theta activity increases decision thresholds, supporting more deliberate responding and nuanced adaptation under task trials that require cognitive control.</div></div><div><h3>Methods</h3><div>We tested 15 patients with PD receiving STN DBS at standard therapeutic frequencies ∼130 Hz and at 4 Hz while performing a Simon reaction-time task and applied computational diffusion decision modeling analyses to quantify the latent cognitive characteristic of response cautiousness via the well-established model parameter known as the decision threshold. This computational analysis better accounts for the speed-accuracy trade off when making deliberate choices.</div></div><div><h3>Results</h3><div>We found that ∼130-Hz STN DBS decreased decision thresholds in line with our prior work, and we report new results showing that 4-Hz STN DBS increased decision thresholds.</div></div><div><h3>Conclusions</h3><div>These findings extend our knowledge of how the STN controls decision thresholds. Future work will study the STN's role in motor and cognitive control and how stimulating this region may modulate cognition in PD.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1021-1027"},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated anxiosomatic circuit TMS: An open-label pilot study in Chinese participants with a treatment-resistant anxiety-related disorder","authors":"Huiru Cui ,&nbsp;Ryan D. Webler ,&nbsp;Lihua Xu ,&nbsp;Zhenying Qian ,&nbsp;Yingying Tang ,&nbsp;Tianhong Zhang ,&nbsp;Chunbo Li ,&nbsp;Shan H. Siddiqi ,&nbsp;Jijun Wang","doi":"10.1016/j.brs.2025.05.102","DOIUrl":"10.1016/j.brs.2025.05.102","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1062-1064"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving cerebellar TMS targeting: MRI-neuronavigation and landmark-based approaches assessed by E-field modeling","authors":"Vridhi Rohira ,&nbsp;Xavier Corominas-Teruel ,&nbsp;Salim Ouarab ,&nbsp;Traian Popa ,&nbsp;Cecile Gallea ,&nbsp;Antoni Valero-Cabré ,&nbsp;Martina Bracco","doi":"10.1016/j.brs.2025.05.010","DOIUrl":"10.1016/j.brs.2025.05.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1052-1055"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pragmatic accelerated transcranial magnetic stimulation for posttraumatic stress disorder","authors":"Noah S. Philip ,&nbsp;F Andrew Kozel ,&nbsp;Elizabeth A. Walter ,&nbsp;Emily K. McMillan ,&nbsp;Bo Dehm Wicklund ,&nbsp;Zachary D. Zuschlag ,&nbsp;Michelle R. Madore","doi":"10.1016/j.brs.2025.05.007","DOIUrl":"10.1016/j.brs.2025.05.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Pages 1059-1061"},"PeriodicalIF":7.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}