Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2024.12.075
Charles Conway
{"title":"Results From A One-Year, Randomized, Sham-Controlled Trial of Vagus Nerve Stimulation In Patients With Treatment-Resistant Depression","authors":"Charles Conway","doi":"10.1016/j.brs.2024.12.075","DOIUrl":"10.1016/j.brs.2024.12.075","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Page 238"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2024.12.073
Mark George
{"title":"A Review of VNS Research and Clinical Findings Up to the Present","authors":"Mark George","doi":"10.1016/j.brs.2024.12.073","DOIUrl":"10.1016/j.brs.2024.12.073","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Page 237"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2024.12.045
Jorge Almeida , Jennifer Siegel-Ramsay , Irving Reti , Nolan Williams , Brandon Bentzley , Kevin Li , Caitlin DuPont , Amy Bichlmeier , Alexa Comfort , Peter Zandi
{"title":"Fast Depressive Symptom Improvement in Bipolar Disorder Type 1 after Stanford Accelerated Intelligent Neuromodulation Therapy: A Two-Site Feasibility and Safety Open Label Trial","authors":"Jorge Almeida , Jennifer Siegel-Ramsay , Irving Reti , Nolan Williams , Brandon Bentzley , Kevin Li , Caitlin DuPont , Amy Bichlmeier , Alexa Comfort , Peter Zandi","doi":"10.1016/j.brs.2024.12.045","DOIUrl":"10.1016/j.brs.2024.12.045","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Page 228"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2025.01.013
Keith Ly , Michael L. Italiano , Mohit N. Shivdasani , David Tsai , Jia-Yi Zhang , Chunhui Jiang , Nigel H. Lovell , Socrates Dokos , Tianruo Guo
{"title":"Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation","authors":"Keith Ly , Michael L. Italiano , Mohit N. Shivdasani , David Tsai , Jia-Yi Zhang , Chunhui Jiang , Nigel H. Lovell , Socrates Dokos , Tianruo Guo","doi":"10.1016/j.brs.2025.01.013","DOIUrl":"10.1016/j.brs.2025.01.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Current brain-based visual prostheses pose significant challenges impeding adoption such as the necessarily complex surgeries and occurrence of more substantial side effects due to the sensitivity of the brain. This has led to much effort toward vision restoration being focused on the more approachable part of the brain - the retina. Here we introduce a novel, parameterised simulation platform that enables study of human retinal degeneration and optimization of stimulation strategies. The platform bears immense potential for patient-specific tailoring and serves to enhance artificial vision solutions for individuals with visual impairments.</div></div><div><h3>Material and method</h3><div>Our virtual retina is developed using the software package, NEURON. This virtual retina platform supports large-scale simulations of over 10,000 neurons whilst upholding strong biological plausibility with multiple important visual pathways and detailed network properties. The comprehensive three-dimensional model includes photoreceptors, horizontal cells, bipolar cells, amacrine cells, and midget and parasol retinal ganglion cells, with comprehensive network connectivity across various eccentricities (1 mm–5 mm from the fovea) in the human retina. The model is constructed using electrophysiology, immunohistology, and optical coherence tomography imaging data from healthy and degenerate human retinas. We validated our model by replicating numerous experimental observations from human and primate retina, with a particular focus on retinal degeneration.</div></div><div><h3>Result</h3><div>We simulated interactions between diseased retinas and state-of-the-art retinal implants, shedding light on the limitations of commercial retinal prostheses. Our results suggested that appropriate stimulation settings with intraretinal prototype devices could leverage network-mediated activation to achieve activation mosaics more alike that of the retina's response to natural light, promoting the prospect of more naturalistic vision. Our study additionally highlights the importance of controlling inhibitory circuits in the retinal network to induce functionally relevant retinal activity.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the potential of this software package and highlights its utility as a valuable tool for engineers, scientists, and clinicians in the design and optimization of retinal stimulation devices for both research and educational applications.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Pages 144-163"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2024.12.048
Andrew Geoly , Afik Faerman , Ian Kratter , John Coetzee , Cammie Rolle , Manish Saggar
{"title":"Temporal Complexity as a Biomarker for Antidepressant Response: Insights from the Distance-Scaled Complexity Index (DSCI) in Stanford Neuromodulation Therapy","authors":"Andrew Geoly , Afik Faerman , Ian Kratter , John Coetzee , Cammie Rolle , Manish Saggar","doi":"10.1016/j.brs.2024.12.048","DOIUrl":"10.1016/j.brs.2024.12.048","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Pages 229-230"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2024.12.039
Natalie Schaworonkow
{"title":"Modeling the Sensorimotor mu-Rhythm: Implications for Corticospinal Excitability and Interpretation of Oscillatory Measures","authors":"Natalie Schaworonkow","doi":"10.1016/j.brs.2024.12.039","DOIUrl":"10.1016/j.brs.2024.12.039","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Page 226"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain StimulationPub Date : 2025-01-01DOI: 10.1016/j.brs.2024.12.026
Hsinju Lee, Fa-Hsuan Lin
{"title":"Personalized targeting cortical locations of the hippocampal network informed by fMRI from a large cohort","authors":"Hsinju Lee, Fa-Hsuan Lin","doi":"10.1016/j.brs.2024.12.026","DOIUrl":"10.1016/j.brs.2024.12.026","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"Page 222"},"PeriodicalIF":7.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}