Brain Stimulation最新文献

{"title":"Transcranial direct current stimulation plus cognitive training for cognitive symptoms in patients with post-acute sequelae of SARS-CoV-2 infection: A randomized, double-blind, sham-controlled trial","authors":"Kallene Summer Vidal ,&nbsp;Beatriz Araújo Cavendish ,&nbsp;Stephan Goerigk ,&nbsp;Mariana Pita Batista ,&nbsp;Alisson Rafael Oliveira Lima ,&nbsp;Bianca Silva Pinto ,&nbsp;Adriano Augusto Neto Domingos ,&nbsp;Juliana Pereira de Sousa ,&nbsp;Rebeca Pelosof ,&nbsp;Laiss Bertola ,&nbsp;Valquiria Silva ,&nbsp;Claudia Kimie Suemoto ,&nbsp;Lais Boralli Razza ,&nbsp;Marom Bikson ,&nbsp;Giuseppina Pilloni ,&nbsp;Leigh Charvet ,&nbsp;Pedro H.R. Silva ,&nbsp;Andre R. Brunoni","doi":"10.1016/j.brs.2025.08.018","DOIUrl":"10.1016/j.brs.2025.08.018","url":null,"abstract":"<div><h3>Background</h3><div>Post-acute sequelae of SARS-CoV-2 infection (PASC) is characterized by persistent cognitive deficits alongside anxiety and depression symptoms that adversely affect quality of life. Cognitive training (CT) programs and non-invasive neuromodulation, specifically transcranial direct current stimulation (tDCS), have each shown promise for alleviating similar deficits in non-clinical populations. However, their combined efficacy has not yet been evaluated in PASC patients. Therefore, this study aimed to determine whether the combination of CT and tDCS produces benefits for cognitive and mood-related symptoms in individuals with PASC.</div></div><div><h3>Methods</h3><div>We conducted a double-blind, randomized, sham-controlled clinical trial in adults aged 18–75 with confirmed SARS-CoV-2 infection within the past six months and persisting cognitive complaints. They were randomized to a 4-week in-person intervention of 20 weekday sessions of either active (2 mA anodal-left, cathodal-right prefrontal stimulation) or sham tDCS paired with an app-based CT program. Primary outcomes were six standardized neuropsychological tests assessing verbal memory, working memory, executive functioning, attention, and language, administered at baseline and immediately post-intervention. As secondary outcomes, we assessed changes in depression and anxiety symptoms over the treatment period.</div></div><div><h3>Results</h3><div>Sixty participants (mean age 43.8 ± 13.2 years, 71.7 % women) were randomized to active tDCS + CT or sham tDCS + CT groups, and 52 finished the trial. Compared to sham, tDCS + CT resulted in significantly greater improvement in tests evaluating inhibitory control (effect size [ES] = 0.07, 95 % CI 0 to 0.23, <em>p</em> = 0.046), processing speed (ES = 0.08, 95 % CI 0 to 0.25, <em>p</em> = 0.034), and divided attention (ES = 0.08, 95 % CI 0 to 0.24, <em>p</em> = 0.039), but not in tests evaluating other domains. Both groups improved similarly in depression and anxiety symptoms. Participant's and rater's active guess rates did not differ between groups (<em>p</em>s &gt; 0.20).</div></div><div><h3>Conclusion</h3><div>An intervention with prefrontal targeted tDCS + CT in patients with PASC with cognitive complaints might be effective in improving attention, processing speed and inhibitory control, although further studies are warranted to prospectively confirm these findings.</div></div><div><h3>Clinicaltrials.gov</h3><div>NCT05389592.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1608-1616"},"PeriodicalIF":8.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transcranial alternating current stimulation (tACS) on neural oscillations in speech perception are replicable and predictable","authors":"Florian H. Kasten ,&nbsp;Zoé Darrasse ,&nbsp;Quentin Busson ,&nbsp;Jules Erkens ,&nbsp;Mathieu Marx ,&nbsp;Benedikt Zoefel","doi":"10.1016/j.brs.2025.08.016","DOIUrl":"10.1016/j.brs.2025.08.016","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1617-1619"},"PeriodicalIF":8.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between concomitant anticonvulsants and clinical and cognitive outcomes of electroconvulsive therapy for depression","authors":"Kevin McDonnell ,&nbsp;Ana Jelovac ,&nbsp;Christopher Mohan ,&nbsp;Emma Whooley ,&nbsp;Anna Igoe ,&nbsp;Cathal McCaffrey ,&nbsp;Sarah Thompson ,&nbsp;Declan M. McLoughlin","doi":"10.1016/j.brs.2025.08.015","DOIUrl":"10.1016/j.brs.2025.08.015","url":null,"abstract":"<div><h3>Background</h3><div>The impact of concomitant anticonvulsant medications on electroconvulsive therapy (ECT) outcomes is not firmly established, with previous studies yielding inconsistent results. This study examined associations between concomitant anticonvulsant use and clinical and cognitive outcomes of ECT for depression.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted in 511 adult inpatients who initiated an acute ECT course for an ICD-10 unipolar or bipolar depressive episode between December 2016 and June 2024. Outcomes included Clinical Global Impression – Improvement (CGI-I) after final ECT, time to reorientation after each session, and electroencephalographic (EEG) and motor seizure duration after each session. Data were analysed using ordinal logistic regression, mixed-effects parametric survival models, and linear mixed-effects models.</div></div><div><h3>Results</h3><div>Of the 511 participants, 107 (20.9 %) were receiving anticonvulsants at pre-ECT baseline. Concomitant anticonvulsant use was associated with a significantly less favourable therapeutic outcome on the CGI-I (adjusted odds ratio = 1.60, 95 % CI: 1.05–2.44, p = 0.028). Conversely, patients on anticonvulsants reoriented significantly faster (adjusted hazard ratio = 1.42, 95 % CI: 1.12–1.80, p = 0.004), as did those whose nighttime dose of anticonvulsant was withheld before ECT (adjusted hazard ratio = 1.24, 95 % CI: 1.02–1.51, p = 0.028), compared to those not on anticonvulsants. Anticonvulsant use was not significantly associated with EEG or motor seizure duration in non-titration sessions.</div></div><div><h3>Conclusions</h3><div>Concomitant use of anticonvulsants in patients treated with ECT for depression was associated with worse clinical response, despite a marginally faster recovery of orientation immediately after treatment sessions. Use of anticonvulsants during ECT requires careful clinical consideration.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1600-1607"},"PeriodicalIF":8.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus","authors":"William W. Watts ,&nbsp;Benjamin Clennell ,&nbsp;James K. Jiang ,&nbsp;Konoha Izaki-Lee ,&nbsp;Abhishek Binodh ,&nbsp;Robyn Cuthell ,&nbsp;Deniz Tonyali ,&nbsp;Jon Crompton ,&nbsp;Rosie Taaffe ,&nbsp;Alanoud Alqahtani ,&nbsp;Anna Andrieu ,&nbsp;Igino Rafael Besinga ,&nbsp;Kate Heesom ,&nbsp;Tom G.J. Steward ,&nbsp;Kwangwook Cho ,&nbsp;Bruce W. Drinkwater ,&nbsp;Elek Molnár ,&nbsp;Daniel J. Whitcomb","doi":"10.1016/j.brs.2025.08.014","DOIUrl":"10.1016/j.brs.2025.08.014","url":null,"abstract":"<div><h3>Background</h3><div>Brief transcranial focused ultrasound stimulation (tFUS) is used in cognitive mapping, where it is assumed that the intervention itself does not cause lasting modifications to the underlying networks being targeted. However, how so-called ‘offline’ effects impact the dynamic function of neural circuits is largely unknown.</div></div><div><h3>Objectives</h3><div>To determine the persistent effects of ultrasound stimulation on hippocampal circuit function.</div></div><div><h3>Methods</h3><div>Acute rat hippocampal slices <em>in vitro</em>, and rat hippocampi <em>in vivo</em>, were exposed to 40 s, 5 Hz pulsed ultrasound or sham stimulation. The effects of ultrasound on the dynamic synaptic and circuit function of the hippocampus were assessed through quantitative proteomics and extracellular field electrophysiology.</div></div><div><h3>Results</h3><div>We find that ultrasound stimulation induces persistent and differential changes in protein expression and kinase activity in the hippocampus. This occurs concurrently with an enhancement of basal synaptic transmission and modifications to the susceptibility for the hippocampal circuit to undergo synaptic plasticity. These effects occur via a canonical Akt-dependent metaplastic process.</div></div><div><h3>Conclusion</h3><div>The results indicate that tFUS can fundamentally modulate key signalling mechanisms that are responsible for determining the synaptic efficacy in a neural circuit. Importantly, these effects last beyond the duration of the stimulus. These findings provide a mechanistic insight into the sustained impact of tFUS on network function, and emphasise the importance of considering such effects in animal and human studies.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1587-1599"},"PeriodicalIF":8.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PlanTUS: A heuristic tool for prospective planning of transcranial ultrasound transducer placements","authors":"Maximilian Lueckel ,&nbsp;Suhas Vijayakumar ,&nbsp;Til Ole Bergmann","doi":"10.1016/j.brs.2025.08.013","DOIUrl":"10.1016/j.brs.2025.08.013","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1563-1565"},"PeriodicalIF":8.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-site beta transcranial alternating current stimulation during a bimanual coordination task modulates functional connectivity between motor areas","authors":"Mareike A. Gann ,&nbsp;Ilenia Paparella ,&nbsp;Catharina Zich ,&nbsp;Ioana-Florentina Grigoras ,&nbsp;Silvana Huertas-Penen ,&nbsp;Sebastian W. Rieger ,&nbsp;Axel Thielscher ,&nbsp;Andrew Sharott ,&nbsp;Charlotte J. Stagg ,&nbsp;Bettina C. Schwab","doi":"10.1016/j.brs.2025.08.011","DOIUrl":"10.1016/j.brs.2025.08.011","url":null,"abstract":"<div><h3>Background</h3><div>Communication within brain networks depends on functional connectivity. One promising approach to modulate such connectivity between cortical areas is dual-site transcranial alternating current stimulation (tACS), which non-invasively applies weak alternating currents to two brain areas.</div></div><div><h3>Objectives</h3><div>In the current study, we aimed to modulate inter-regional functional connectivity with dual-site tACS to bilateral primary motor cortices (M1s) during bimanual coordination and, in turn, alter behaviour.</div></div><div><h3>Methods</h3><div>Using functional magnetic resonance imaging (fMRI), we recorded participants’ brain responses during a bimanual coordination task in a concurrent tACS-fMRI design. While performing a slow and fast version of the task, participants received one of three types of beta (20 Hz) dual-site tACS over both M1s: zero-phase, jittered-phase or sham, in a within-participant, repeated measures design.</div></div><div><h3>Results</h3><div>While we did not observe any significant tACS effects on behaviour, the study revealed an attenuation effect of zero-phase tACS on interhemispheric connectivity. Additionally, the two active types of tACS (zero-phase and jittered-phase) differed in the task-related M1 connectivity with other motor cortical regions, such as premotor cortex and supplementary motor area. Furthermore, individual E-field strengths were related to functional connectivity in the zero-phase condition.</div></div><div><h3>Conclusions</h3><div>Dual-site beta tACS over both M1s altered functional connectivity between motor areas. However, this effect did not translate significantly to the behavioural level in the presence of a restricted sample size. Future studies may thus integrate mechanistic measures, such as measures of interhemispheric inhibition, to strengthen causal interpretations.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1566-1578"},"PeriodicalIF":8.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.","authors":"Ilya Demchenko, Ishaan Tailor, Sina Chegini, Haochen Yu, Fatemeh Gholamali Nezhad, Alice Rueda, Anne Kever, Sridhar Krishnan, Abhishek Datta, Jed A Meltzer, Simon J Graham, Tom A Schweizer, Sumientra Rampersad, Edward S Boyden, Ines R Violante, Robert Chen, Andres M Lozano, Venkat Bhat","doi":"10.1016/j.brs.2025.08.010","DOIUrl":"https://doi.org/10.1016/j.brs.2025.08.010","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the editor due to an error in the publishing process. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies-and-standards/article-withdrawal.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of non-invasive brain stimulation on cognitive performance in patients treated for chronic pain syndrome","authors":"Jean-Pascal Lefaucheur","doi":"10.1016/j.brs.2025.08.007","DOIUrl":"10.1016/j.brs.2025.08.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1561-1562"},"PeriodicalIF":8.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subthalamic nucleus deep brain stimulation for cranial-cervical dystonia: optimal stimulation sites and networks","authors":"Hutao Xie ,&nbsp;Jiansong Huang ,&nbsp;Ningfei Li ,&nbsp;Houyou Fan ,&nbsp;Shihang Yang ,&nbsp;Zixiao Yin ,&nbsp;Zhaoting Zheng ,&nbsp;Zehua Zhao ,&nbsp;Yin Jiang ,&nbsp;Lin Shi ,&nbsp;Anchao Yang ,&nbsp;Fangang Meng ,&nbsp;Guanyu Zhu ,&nbsp;Quan Zhang ,&nbsp;Jianguo Zhang","doi":"10.1016/j.brs.2025.08.003","DOIUrl":"10.1016/j.brs.2025.08.003","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory cranial-cervical dystonia (CCD or Meige syndrome). However, clinical responses vary substantially across individuals, likely due to differences in electrode placement and modulation of target neural circuits.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 51 patients with CCD treated with STN-DBS at a single center. Pre- and postoperative imaging was used to reconstruct electrode locations and model patient-specific electric fields. We then performed (i) voxel-wise sweet spot mapping to identify optimal stimulation sites, (ii) fiber filtering using normative tractography to determine white matter pathways associated with clinical improvement, and (iii) network mapping based on resting-state fMRI to identify functional connectivity patterns predictive of DBS response.</div></div><div><h3>Results</h3><div>Voxel-wise correlation analysis revealed that the optimal stimulation localized to the STN motor subregion (<em>R</em> = 0.52, <em>p</em> &lt; 0.001). Normative structural connectivity analysis showed that symptom improvement correlated strongly with modulation of fibers projecting to the cranial and cervical regions of sensorimotor cortex (<em>R</em> = 0.52, <em>p</em> &lt; 0.001) and sensorimotor-associated basal ganglia pathways (<em>R</em> = 0.62, <em>p</em> &lt; 0.001). Functional network mapping further revealed connectivity to the sensorimotor cortex as significantly associated with clinical improvement (<em>R</em> = 0.43, <em>p</em> = 0.002).</div></div><div><h3>Conclusion</h3><div>These findings inform refinement of STN targeting strategies in DBS for CCD. The involvement of cranial and cervical sensorimotor regions highlights the importance of symptom-based dystonia classification for individualized neuromodulation approaches.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1539-1550"},"PeriodicalIF":8.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of acute neuroplastic response to taVNS in treatment outcome in persistent abdominal pain: A concurrent taVNS-EEG trial","authors":"Suping Cai ,&nbsp;Qihan Li ,&nbsp;Lina Liu ,&nbsp;Qingchuan Zhao ,&nbsp;Qinxian Huang ,&nbsp;Kai Yuan","doi":"10.1016/j.brs.2025.08.009","DOIUrl":"10.1016/j.brs.2025.08.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1511-1513"},"PeriodicalIF":8.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}