Brain Stimulation最新文献

{"title":"Enhancement of temporal processing via transcutaneous vagus nerve stimulation","authors":"Mehrdad Bahadori, Neha Bhutani, Simone Dalla Bella","doi":"10.1016/j.brs.2024.07.006","DOIUrl":"10.1016/j.brs.2024.07.006","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 925-927"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001219/pdfft?md5=de5181a0d70dcecfe1f6ad69535175a7&pid=1-s2.0-S1935861X24001219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical recommendations for non-invasive ultrasound neuromodulation","authors":"Roland Beisteiner ,&nbsp;Andres Lozano ,&nbsp;Vincenzo Di Lazzaro ,&nbsp;Mark S. George ,&nbsp;Mark Hallett","doi":"10.1016/j.brs.2024.07.013","DOIUrl":"10.1016/j.brs.2024.07.013","url":null,"abstract":"<div><p>Non-invasive ultrasound neuromodulation has experienced exponential growth in the neuroscientific literature, recently also including clinical studies and applications. However, clinical recommendations for the secure and effective application of ultrasound neuromodulation in pathological brains are currently lacking. Here, clinical experts with neuroscientific expertise in clinical brain stimulation and ultrasound neuromodulation present initial clinical recommendations for ultrasound neuromodulation with relevance for all ultrasound neuromodulation techniques. The recommendations start with methodological safety issues focusing on technical issues to avoid harm to the brain. This is followed by clinical safety issues focusing on important factors concerning pathological situations.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 890-895"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001293/pdfft?md5=c97214ad2e2c5a0395354a287619c313&pid=1-s2.0-S1935861X24001293-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the effects of rTMS over the dorsolateral prefrontal cortex on pain: An updated systematic review and meta-analysis","authors":"Jie Zhou ,&nbsp;Ying Wang ,&nbsp;Xi Luo ,&nbsp;Paul B. Fitzgerald ,&nbsp;Robin F.H. Cash ,&nbsp;Bernadette M. Fitzgibbon ,&nbsp;Xianwei Che","doi":"10.1016/j.brs.2024.07.011","DOIUrl":"10.1016/j.brs.2024.07.011","url":null,"abstract":"<div><h3>Background</h3><p>Our previous study synthesized the analgesic effects of repetitive Transcranial Magnetic Stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) trials up to 2019. There has been a significant increase in pain trials in the past few years, along with methodological variabilities such as sample size, stimulation intensity, and rTMS paradigms. <em>Objectives/Methods</em>: This study therefore updated the effects of DLPFC-rTMS on chronic pain and quantified the impact of methodological differences across studies.</p></div><div><h3>Results</h3><p>A total of 36 studies were included. Among them, 26 studies were clinical trials (update = 9, 307/711 patients), and 10 (update = 1, 34/249 participants) were provoked pain studies. The updated meta-analysis does not support an effect on neuropathic pain after including the additional trials (p_short-term = 0.20, p_mid-term = 0.50). However, there is medium-to-large analgesic effect in migraine trials extending up to six weeks follow-up (SMD_mid-term = −0.80, SMD_long-term = −0.51), that was not previously reported. Methodological differences wthine the studies were considered. DLPFC-rTMS also induces potential improvement in the emotional aspects of pain (SMD_short-term = −0.28).</p></div><div><h3>Conclusions</h3><p>The updated systematic meta-analysis continues to support analgesic effects for chronic pain overall. However, the updated results no longer support DLPFC-rTMS for pain relief in neuropathic pain, and do supports DLPFC-rTMS in the management of migraine. There is also evidence for DLPFC-rTMS to improve emotional aspects of pain.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 928-937"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001268/pdfft?md5=361526da8c3297f9dfaa994412a1d8f5&pid=1-s2.0-S1935861X24001268-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial magnetic stimulation of primary motor cortex elicits an immediate transcranial evoked potential","authors":"Mikkel Malling Beck ,&nbsp;Lasse Christiansen ,&nbsp;Mads Alexander Just Madsen ,&nbsp;Armita Faghani Jadidi ,&nbsp;Mikkel Christoffer Vinding ,&nbsp;Axel Thielscher ,&nbsp;Til Ole Bergmann ,&nbsp;Hartwig Roman Siebner ,&nbsp;Leo Tomasevic","doi":"10.1016/j.brs.2024.06.008","DOIUrl":"10.1016/j.brs.2024.06.008","url":null,"abstract":"<div><h3>Background</h3><p>Transcranial evoked potentials (TEPs) measured via electroencephalography (EEG) are widely used to study the cortical responses to transcranial magnetic stimulation (TMS). Immediate transcranial evoked potentials (i-TEPs) have been obscured by pulse and muscular artifacts. Thus, the TEP peaks that are commonly reported have latencies that are too long to be caused by direct excitation of cortical neurons.</p></div><div><h3>Methods</h3><p>In 25 healthy individuals, we recorded i-TEPs evoked by a single biphasic TMS pulse targeting the primary motor hand area (M1_HAND) or parietal or midline control sites. Sampling EEG at 50 kHz enabled us to reduce the duration of the TMS pulse artifact to a few milliseconds, while minor adjustments of the TMS coil tilt or position enabled us to avoid cranial muscular twitches during the experiment.</p></div><div><h3>Results</h3><p>We observed an early positive EEG deflection starting after approx. 2 ms followed by a series of superimposed peaks with an inter-peak interval of ∼1.1–1.4 ms in multiple electrodes surrounding the stimulated sensorimotor region. This multi-peak i-TEP response was only evoked by TMS of the M1_HAND region and was modified by changes in stimulation intensity and current direction.</p></div><div><h3>Discussion</h3><p>Single-pulse TMS of the M1_HAND evokes an immediate local multi-peak response at the cortical site of stimulation. Our results suggest that the observed i-TEP patterns are genuine cortical responses evoked by TMS caused by synchronized excitation of pyramidal neurons in the targeted precentral cortex. This notion needs to be corroborated in future studies, including further investigations into the potential contribution of instrumental or physiological artifacts.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 802-812"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001141/pdfft?md5=1d5edd12ef2722d2c9efe9e9da4ed380&pid=1-s2.0-S1935861X24001141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the left inferior frontal gyrus on fear extinction: A transcranial direct current stimulation study","authors":"Yuanbo Ma ,&nbsp;Fujia Jiao ,&nbsp;Giorgi Batsikadze ,&nbsp;Fatemeh Yavari ,&nbsp;Michael A. Nitsche","doi":"10.1016/j.brs.2024.07.004","DOIUrl":"10.1016/j.brs.2024.07.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Fear extinction is a fundamental component of exposure-based therapies for anxiety-related disorders. The renewal of fear in a different context after extinction highlights the importance of contextual factors. In this study, we aimed to investigate the causal role of the left inferior frontal gyrus (LiFG) in the context-dependency of fear extinction learning via administration of transcranial direct current stimulation (tDCS) over this area.</p></div><div><h3>Methods</h3><p>180 healthy subjects were assigned to 9 groups: 3 tDCS conditions (anodal, cathodal, and sham) × 3 context combinations (AAA, ABA, and ABB). The fear conditioning/extinction task was conducted over three consecutive days: acquisition, extinction learning, and extinction recall. tDCS (2 mA, 10min) was administered during the extinction learning phase over the LiFG via a 4-electrode montage. Skin conductance response (SCR) data and self-report assessments were collected.</p></div><div><h3>Results</h3><p>During the extinction learning phase, groups with excitability-enhancing anodal tDCS showed a significantly higher fear response to the threat cues compared to cathodal and sham stimulation conditions, irrespective of contextual factors. This effect was stable until the extinction recall phase. Additionally, excitability-reducing cathodal tDCS caused a significant decrease of the response difference between the threat and safety cues during the extinction recall phase. The self-report assessments showed no significant differences between the conditions throughout the experiment.</p></div><div><h3>Conclusion</h3><p>Independent of the context, excitability enhancement of the LiFG did impair fear extinction, and led to preservation of fear memory. In contrast, excitability reduction of this area enhanced fear extinction retention. These findings imply that the LiFG plays a role in the fear extinction network, which seems to be however context-independent.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 816-825"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001190/pdfft?md5=9a908b2d96391c19f1f182db342cba73&pid=1-s2.0-S1935861X24001190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of rotational field TMS in major depressive disorder – A pilot study","authors":"Shmuel Hess ,&nbsp;Maor Yeshua ,&nbsp;Ami Eisen,&nbsp;Yuri Burnishev,&nbsp;Elsa Sultan,&nbsp;Gaby Pell,&nbsp;Colleen A. Hanlon,&nbsp;Abraham Weizman,&nbsp;Abraham Zangen,&nbsp;Yiftach Roth,&nbsp;Elisha Moses,&nbsp;Dror Weiss","doi":"10.1016/j.brs.2024.07.017","DOIUrl":"10.1016/j.brs.2024.07.017","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 907-910"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001323/pdfft?md5=2c939d011f86b056b4f5ca21ab9e9efc&pid=1-s2.0-S1935861X24001323-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological sweet spot mapping in deep brain stimulation for Parkinson's disease patients","authors":"Jana Peeters ,&nbsp;Tine Van Bogaert ,&nbsp;Alexandra Boogers ,&nbsp;Robin Gransier ,&nbsp;Jan Wouters ,&nbsp;Philippe De Vloo ,&nbsp;Wim Vandenberghe ,&nbsp;Michael T. Barbe ,&nbsp;Veerle Visser-Vandewalle ,&nbsp;Bart Nuttin ,&nbsp;Till A. Dembek ,&nbsp;Myles Mc Laughlin","doi":"10.1016/j.brs.2024.05.013","DOIUrl":"10.1016/j.brs.2024.05.013","url":null,"abstract":"<div><h3>Background</h3><p>Subthalamic deep brain stimulation (STN-DBS) is a well-established therapy to treat Parkinson's disease (PD). However, the STN-DBS sub-target remains debated. Recently, a white matter tract termed the hyperdirect pathway (HDP), directly connecting the motor cortex to STN, has gained interest as HDP stimulation is hypothesized to drive DBS therapeutic effects. Previously, we have investigated EEG-based evoked potentials (EPs) to better understand the neuroanatomical origins of the DBS clinical effect. We found a 3-ms peak (P3) relating to clinical benefit, and a 10-ms peak (P10) suggesting nigral side effects. Here, we aimed to investigate the neuroanatomical origins of DBS EPs using probabilistic mapping.</p></div><div><h3>Methods</h3><p>EPs were recorded using EEG whilst low-frequency stimulation was delivered at all DBS-contacts individually. Next, EPs were mapped onto the patients’ individual space and then transformed to MNI standard space. Using voxel-wise and fiber-wise probabilistic mapping, we determined hotspots/hottracts and coldspots/coldtracts for P3 and P10. Topography analysis was also performed to determine the spatial distribution of the DBS EPs.</p></div><div><h3>Results</h3><p>In all 13 patients (18 hemispheres), voxel- and fiber-wise probabilistic mapping resulted in a P3-hotspot/hottract centered on the posterodorsomedial STN border indicative of HDP stimulation, while the P10-hotspot/hottract covered large parts of the substantia nigra.</p></div><div><h3>Conclusion</h3><p>This study investigated EP-based probabilistic mapping in PD patients during STN-DBS, revealing a P3-hotspot/hottract in line with HDP stimulation and P10-hotspot/hottract related to nigral stimulation. Results from this study provide key evidence for an electrophysiological measure of HDP and nigral stimulation.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 794-801"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24000950/pdfft?md5=0ed7cc9e424d6214720ea35a4915f4d6&pid=1-s2.0-S1935861X24000950-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood trauma and response to electroconvulsive therapy for depression: A pilot study","authors":"Sarah Thompson ,&nbsp;Martha Finnegan ,&nbsp;Toni Galligan,&nbsp;Ana Jelovac,&nbsp;Declan M. McLoughlin","doi":"10.1016/j.brs.2024.07.012","DOIUrl":"10.1016/j.brs.2024.07.012","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 864-866"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X2400127X/pdfft?md5=141ccc059bf617c0af8fef5a538fe2f2&pid=1-s2.0-S1935861X2400127X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Effects of 5 Hz rTMS on post-stroke urinary retention","authors":"Juan Xiao,&nbsp;Yanan Xu,&nbsp;Wenjun Mi,&nbsp;Anming Hu,&nbsp;Xiaoping Kang","doi":"10.1016/j.brs.2024.07.010","DOIUrl":"10.1016/j.brs.2024.07.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 887-889"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001256/pdfft?md5=d6bc408b432a5a5e7e71db9b482f60fc&pid=1-s2.0-S1935861X24001256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the disease and location specificity of evoked resonant neural activity","authors":"Tine Van Bogaert,&nbsp;Alexandra Boogers,&nbsp;Jana Peeters,&nbsp;Wim Vandenberghe,&nbsp;Philippe De Vloo,&nbsp;Bart Nuttin,&nbsp;Myles Mc Laughlin","doi":"10.1016/j.brs.2024.07.003","DOIUrl":"10.1016/j.brs.2024.07.003","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 813-815"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001177/pdfft?md5=39d546cc53f623f809bf315b4e7d8f7c&pid=1-s2.0-S1935861X24001177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}