Brain Stimulation最新文献

{"title":"Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial.","authors":"A John Rush, Charles R Conway, Scott T Aaronson, Mark S George, Patricio Riva-Posse, David L Dunner, John Zajecka, Mark T Bunker, João Quevedo, Rebecca M Allen, Gustavo Alva, Heather Luing, Ziad Nahas, Lucian Manu, Jeffrey I Bennett, Brian J Mickey, Jonathan Becker, Yvette Sheline, Cristina Cusin, James W Murrough, Kevin Reeves, Peter B Rosenquist, Ying-Chieh Lisa Lee, Shannon Majewski, Jeffrey Way, Bryan Olin, Harold A Sackeim","doi":"10.1016/j.brs.2024.12.1187","DOIUrl":"https://doi.org/10.1016/j.brs.2024.12.1187","url":null,"abstract":"<p><strong>Background: </strong>Depression treatments aim to minimize symptom burden and optimize quality of life (QoL) and psychosocial function.</p><p><strong>Objective: </strong>Compare the effects of adjunctive versus sham vagus nerve stimulation (VNS) on QoL and function in markedly treatment-resistant depression (TRD).</p><p><strong>Methods: </strong>In this multicenter, double-blind, sham-controlled trial, 493 adults with TRD and ≥4 adequate but unsuccessful antidepressant treatment trials (current episode) were randomized to active (n = 249) or sham (n = 244) VNS (plus treatment as usual) over a 12-month observation period. Quarterly outcomes included QoL with the Q-LES-Q, Mini-Q-LES-Q, and EQ-5D-5L, and function with the WHODAS 2.0 and Work Productivity and Activity Impairment Questionnaire (WPAI) item 6. Differences between treatment groups in change in scores from baseline and percentage of time with a meaningful response in Q-LES-Q, Mini-Q-LES-Q, and WPAI item 6 scores were analyzed.</p><p><strong>Results: </strong>Active VNS was superior to sham in mean change in scores from baseline in the Mini-Q-LES-Q (P = 0.050) and WPAI item 6 (health condition's effect on regular activities [P = 0.050]) used as continuous variables, with a similar trend for Q-LES-Q (P = 0.061). Active VNS was superior to sham in time spent in clinically meaningful benefit (categorical analyses) using the Q-LES-Q (P = 0.029), Mini-Q-LES-Q (P = 0.011), and WPAI item 6 (P = 0.039). The WHODAS 2.0 (P = 0.304) and EQ-5D visual analog scale (P = 0.125) failed to reveal between-group differences.</p><p><strong>Conclusion: </strong>Active VNS was superior to sham VNS in improving QoL and psychosocial function in patients with TRD. VNS has a broader therapeutic impact than symptom improvement alone in patients with marked psychosocial impairment.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound neuromodulation - How deep can we stimulate?","authors":"Roland Beisteiner, Eva Matt","doi":"10.1016/j.brs.2024.12.1189","DOIUrl":"10.1016/j.brs.2024.12.1189","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"15-18"},"PeriodicalIF":7.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of non-invasive brain stimulation over the supplementary motor area on motor function in Parkinson's disease: A systematic review and meta-analysis.","authors":"Yawen Chen, Hanhong Jiang, Yixin Wei, Saiqing Ye, Jiaxin Jiang, Margaret Mak, Marco Y C Pang, Qiang Gao, Meizhen Huang","doi":"10.1016/j.brs.2024.12.005","DOIUrl":"10.1016/j.brs.2024.12.005","url":null,"abstract":"<p><strong>Background: </strong>Motor dysfunction profoundly affects individuals with Parkinson's disease (PD). Non-invasive brain stimulation (NIBS) targeting the supplementary motor area (SMA), a critical region for movement-related processing, offers a promising approach to enhance motor function for PD.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aims to evaluate the efficacy of NIBS over the SMA (SMA-NIBS) in alleviating motor symptoms in PD.</p><p><strong>Methods: </strong>We conducted literature searches in MEDLINE, EMBASE, Physiotherapy Evidence Database, Web of Science, the Chinese National Knowledge Infrastructure, and Scopus. The meta-analysis utilized an inverse variance method and a random-effects model. Subgroup analyses were performed based on stimulation types (e.g., TMS and tDCS), stimulation protocols (e.g., facilitatory and inhibitory stimulation), and medication status during stimulation.</p><p><strong>Results: </strong>Twenty randomized control trials involving 442 individuals with PD were included. Compared to sham stimulation, SMA-NIBS significantly improved motor function as measured by the motor section of Unified Parkinson's Disease Rating Scale (UPDRS-III) (mean differences [MD]: -3.45, 95 % confidence interval [CI]: -5.65 to -1.26). Subgroup analysis revealed that only TMS (MD: -3.62, 95%CI: -6.15 to -1.08), not tDCS (MD: -2.47, 95 % CI: -5.03 to 0.08), has significant effect on motor function. Both facilitatory (MD: -2.59, 95 % CI: -3.37 to -1.82) and inhibitory stimulation (MD: -4.98, 95 % CI: -9.29 to -0.66) significantly improved the UPDRS-III score. Effectiveness was observed only during ON medication. Statistically significant effects of SMA-NIBS were reported on Freezing of Gait Questionnaire, not timed up and go test and walking speed.</p><p><strong>Conclusion: </strong>SMA-NIBS is a promising approach to enhance motor function in PD.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1-14"},"PeriodicalIF":7.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Brain Stimulation of the Medial Forebrain Bundle: Effects on Anhedonia and Behavioral Activation in Treatment-Resistant Depression.","authors":"Andrea Boscutti, Bashar Asir, Isabela Moura, Albert Fenoy, João Quevedo, Jair C Soares","doi":"10.1016/j.brs.2024.12.1186","DOIUrl":"https://doi.org/10.1016/j.brs.2024.12.1186","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open-source toolbox for EEG-based Stimulation Monitoring (EStiMo) of brain states during TMS burst delivery.","authors":"Armita Faghani Jadidi, Adam Ryszczuk, Domenico Voso, Angela Mastropasqua, Leo Tomasevic, Hartwig Roman Siebner","doi":"10.1016/j.brs.2024.12.001","DOIUrl":"10.1016/j.brs.2024.12.001","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"22-24"},"PeriodicalIF":7.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing cortical reactivity before and after brain tumor resection: A TMS-EEG case.","authors":"Giulia Meneghini, Melina Engelhardt, Milena Burzlaff, Aleksandra Zaykova, Peter Vajkoczy, Pantelis Lioumis, Mario Rosanova, Thomas Picht","doi":"10.1016/j.brs.2024.12.004","DOIUrl":"10.1016/j.brs.2024.12.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"19-21"},"PeriodicalIF":7.6,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of white matter variability in TMS neuromodulatory effects","authors":"Mar Martín-Signes ,&nbsp;Pablo Rodríguez-San Esteban ,&nbsp;Cristina Narganes-Pineda ,&nbsp;Alfonso Caracuel ,&nbsp;José Luís Mata ,&nbsp;Elisa Martín-Arévalo ,&nbsp;Ana B. Chica","doi":"10.1016/j.brs.2024.11.006","DOIUrl":"10.1016/j.brs.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial Magnetic Stimulation (TMS) is a widely used tool to explore the causal role of focal brain regions in cognitive processing. TMS effects over attentional processes are consistent and replicable, while at the same time subjected to individual variability. This individual variability needs to be understood to better comprehend TMS effects, and most importantly, its clinical applications.</div></div><div><h3>Objective</h3><div>This study aimed to explore the role of white matter variability in TMS neuromodulatory effects on behavior in healthy participants (N = 50).</div></div><div><h3>Methods</h3><div>Participants completed an attentional task in which orienting and alerting cues preceded near-threshold targets. Continuous Theta Burst Stimulation (cTBS) was applied over the left frontal eye field (FEF) or an active vertex condition. White matter was explored with diffusion-weighted imaging tractography and Tract-Based Spatial Statistics (TBSS).</div></div><div><h3>Results</h3><div>Behaviorally, TMS over the left FEF slowed down reaction times (especially in the alerting task), impaired accuracy in the objective task, and reduced the proportion of seen targets (as compared to the vertex condition). Attentional effects increased, overall, when TMS was applied to the left FEF as compared to the vertex condition. Correlations between white matter and TMS effects showed i) reduced TMS effects associated with the microstructural properties of long-range white matter pathways such as the superior longitudinal fasciculus (SLF), and interhemispheric fibers of the corpus callosum (CC), and ii) increased TMS effects in participants with high integrity of the CC connecting the stimulated region with the opposite hemisphere. Additionally, variability in attentional effects was also related to white matter, showing iii) increased alerting effects in participants with low integrity of association, commissural, and projection fibers, and iv) increased orienting effects in participants with high integrity of the right SLF III.</div></div><div><h3>Conclusion</h3><div>All these observations highlight the importance of taking into account individual variability in white matter for the understanding of cognitive processing and brain neuromodulation effects.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1265-1276"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of stimulation intensity- and cortical activity-dependent TMS-evoked reactivity in poststroke primary motor cortex","authors":"Zhongfei Bai ,&nbsp;Jack Jiaqi Zhang ,&nbsp;Eden Chun Hang Ti ,&nbsp;Minxia Jin,&nbsp;Feifei Zhu,&nbsp;Shan Liang,&nbsp;Jing Zhang,&nbsp;Yefang Yang,&nbsp;Ronghua Hong,&nbsp;Danmei Lan,&nbsp;Raymond Kai Yu Tong,&nbsp;Ulf Ziemann,&nbsp;Lingjing Jin","doi":"10.1016/j.brs.2024.11.009","DOIUrl":"10.1016/j.brs.2024.11.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1286-1289"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex","authors":"Areej Ennasr ,&nbsp;Gabriel Isaac ,&nbsp;Andrew Strohman ,&nbsp;Wynn Legon","doi":"10.1016/j.brs.2024.11.005","DOIUrl":"10.1016/j.brs.2024.11.005","url":null,"abstract":"<div><h3>Background</h3><div>Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by a rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect and interaction of these parameters to affect human brain activity is poorly understood. A better understanding of how parameters interact is critical to advance LIFU as a potential therapeutic.</div></div><div><h3>Objective/hypothesis</h3><div>To determine how intensity, duration, and duty cycle interact to produce neuromodulation effects in the human motor cortex. Further, this study assesses the effect of pulsing versus continuous ultrasound. We hypothesize that higher duty cycles will confer excitation. Increasing intensity or duration will increase the magnitude of effect. Pulsing LIFU will not be more effective than continuous wave ultrasound.</div></div><div><h3>Methods</h3><div>N = 18 healthy human volunteers underwent 20 different parameter combinations that included a fully parametrized set of two intensities (I_SPPA: 6 &amp; 24 W/cm²), five duty cycles (1, 10, 30, 50, 70 %) and two durations (100, 500 msec) with a constant pulse repetition frequency of 1 kHz delivered concurrently with transcranial magnetic stimulation (TMS) to the primary motor cortex (M1). Four of these parameter combinations were also delivered continuously, matched on the number of cycles. Motor-evoked potential (MEP) amplitude was the primary outcome measure. All parameter combinations were collected time-locked to MEP generation.</div></div><div><h3>Results</h3><div>There was no evidence of excitation from any parameter combination. 3 of the 24 parameter sets resulted in significant inhibition. The parameter set that resulted in the greatest inhibition (∼30 %) was an intensity of 6W/cm² with a duty cycle of 30 % and a duration of 500 msec. A three-way ANOVA revealed an interaction of intensity and duty cycle. The analysis of continuous versus pulsed ultrasound revealed a 3-way interaction of intensity, pulsing, and the number of cycles such that under the 6W/cm² condition higher cycles of pulsed ultrasound resulted in inhibition whereas lower number of cycles using continuous LIFU resulted in inhibition.</div></div><div><h3>Conclusions</h3><div>LIFU to M1 in humans, in the range employed, either conferred inhibition or had no effect. Significant excitation was not observed. In general, lower intensity looks to be more efficacious for inhibition that depends on duration. In addition, pulsed ultrasound looks to be more effective for inhibition as compared to continuous wave after controlling for total energy delivered. Non-specific auditory effects may contribute to these results.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1293-1306"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the hypotensive effect of focused ultrasound neuromodulation and barbiturate-loaded nanodroplets in healthy and hypertensive rats.","authors":"Harriet Lea-Banks, Neha Chauhan, Kullervo Hynynen","doi":"10.1016/j.brs.2024.12.002","DOIUrl":"10.1016/j.brs.2024.12.002","url":null,"abstract":"<p><strong>Background: </strong>Current strategies for reducing blood pressure (BP) are ineffective and unsafe for many patient populations, including drug-resistant hypertension and during pregnancy. Stimulating the periaqueductal grey (PAG) region has shown promise in treating drug-resistant hypertension in patients using deep brain stimulation.</p><p><strong>Objective: </strong>To develop a minimally invasive neuromodulation technique for the sustained treatment of hypertension.</p><p><strong>Methods: </strong>We have investigated BP reduction using focused ultrasound (FUS) (540 kHz) and anesthetic-loaded ultrasound-responsive nanodroplets to deliver pentobarbital to the PAG in normotensive (N = 27) and hypertensive (N = 20) male and female rats. BP, heart rate and plasma hormone content were collected before and after FUS exposure, and neuronal activity was mapped in the PAG using C-Fos and neuron subtype staining. Cavitation activity was monitored by detecting acoustic emissions from vaporizing nanodroplets, and neuromodulation was verified with immunohistochemistry.</p><p><strong>Results: </strong>Systolic and diastolic BP were reduced for 6 h following a single sonication of the PAG (-37/-28 mmHg systolic/diastolic), and the offline effect was extended to 4 days with consecutive sonications combined with systemically injected pentobarbital-loaded nanodroplets. In contrast, FUS applied to the frontal cortex had no effect on BP. Immunohistochemistry revealed stimulation of inhibitory neurons in the PAG region, indicating that the hypotensive effect was associated with a GABAergic pathway. The acoustic emissions from vaporizing droplets were found to correlate with neuron activity and change in BP, offering the potential for real-time treatment monitoring using ultrasound.</p><p><strong>Conclusions: </strong>This work has implications for developing a new treatment for hypertension that has greater safety and broader applicability for vulnerable patient populations.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1317-1327"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}