Brain Stimulation最新文献

Cognitive Effects of Spaced Transcranial Direct Current Stimulation in Major Depression.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-25 DOI: 10.1016/j.brs.2025.03.016

Véronique Desbeaumes Jodoin, Emma Bousseau, Maxime Couture, Paul Lespérance, Jean-Philippe Miron

引用次数: 0

Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): a role for microglia.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-19 DOI: 10.1016/j.brs.2025.03.012

Paolo d'Errico, Iris Früholz, Melanie Meyer-Luehmann, Andreas Vlachos

{"title":"Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): a role for microglia.","authors":"Paolo d'Errico, Iris Früholz, Melanie Meyer-Luehmann, Andreas Vlachos","doi":"10.1016/j.brs.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.012","url":null,"abstract":"Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to modulate neocortical excitability, with expanding applications in neurological and psychiatric disorders. However, the cellular and molecular mechanisms underlying its effects, particularly the role of microglia-the resident immune cells of the central nervous system-remain poorly understood. This review synthesizes recent findings on how different rTMS protocols influence microglial function under physiological conditions and in disease models. Emerging evidence indicates that rTMS modulates microglial activation, promoting neuroprotective and plasticity-enhancing processes not only in models of brain disorders, such as Alzheimer's and Parkinson's disease, but also in healthy neural circuits. While much of the current research has focused on the inflammatory profile of microglia, critical aspects such as activity-dependent synaptic remodeling, phagocytic activity, and process motility remain underexplored. Given the substantial heterogeneity of microglial responses across brain regions, age, and sex, as well as their differential roles in health and disease, a deeper understanding of their involvement in rTMS-induced plasticity is essential. Future studies should integrate selective microglial manipulation and advanced structural, functional, and molecular profiling techniques to clarify their causal involvement. Addressing these gaps will be pivotal in optimizing rTMS protocols and maximizing its therapeutic potential across a spectrum of neurological and neuropsychiatric conditions.","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerated iTBS with a personalised targeting method to treat negative symptoms of schizophrenia: A randomized controlled trial.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-19 DOI: 10.1016/j.brs.2025.03.014

Yunyi Han, Fang Jin, Jimmy Lee, Wenpeng Hou, Xue Yang, Yiming Zhang, Yueying Zhang, Xuefeng Lu, Zhimin Wang, Qijing Bo, Zhengyi Yang, Fuchun Zhou, Tianzi Jiang, Chuanyue Wang

{"title":"Accelerated iTBS with a personalised targeting method to treat negative symptoms of schizophrenia: A randomized controlled trial.","authors":"Yunyi Han, Fang Jin, Jimmy Lee, Wenpeng Hou, Xue Yang, Yiming Zhang, Yueying Zhang, Xuefeng Lu, Zhimin Wang, Qijing Bo, Zhengyi Yang, Fuchun Zhou, Tianzi Jiang, Chuanyue Wang","doi":"10.1016/j.brs.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.014","url":null,"abstract":"Background: The efficacy of non-invasive brain stimulation in ameliorating schizophrenia's negative symptoms remains to be validated. The mesocortical pathway, mostly comprising the ventral tegmental area (VTA) and prefrontal cortex, is the core neural circuit underlying negative symptoms. This study aimed to assess the clinical and biological effects of accelerated intermittent theta burst stimulation (iTBS) targeted to the dorsolateral prefrontal cortex (dlPFC), guided by personalised dlPFC-VTA functional connectivity (FC).Methods: Eighty schizophrenia patients with predominant negative symptoms received 40 sessions of either active (n = 40) or sham (n = 40) accelerated iTBS (1800 pulses) in two weeks, targeting the region of the left dlPFC most functionally correlated with the VTA. Clinical and cognitive follow-ups occurred at week 4, 8, and 12. The primary outcome was the alteration in PANSS negative symptom (PANSS-NS) scores at week 4, while secondary outcomes included additional clinical, cognitive assessments and neuroimaging alterations.Results: At week 4, the active group showed a significant reduction in PANSS-NS compared to the sham group, with a significant group × time interaction effect (P < 0.001, mean difference = 4.10, Cohen's d = 0.83). At week 2, compared to the sham group, the active group exhibited reduced left temporal middle gyrus (TMG) (r = -0.29, p = 0.01) activation and FC between the VTA and left TMG (r = -0.34, p = 0.003), and both were negatively correlated with PANSS-NS changes in both groups.Conclusion: Accelerated iTBS targeting the personalised region determined by dlPFC-VTA FC is an effective intervention to alleviate negative symptoms of schizophrenia.","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor treating fields may improve the prognosis of patients with lung cancer brain metastases.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-18 DOI: 10.1016/j.brs.2025.03.003

Junsong Peng, Liyang Zhang, Yinghua Wu, Ling Chen, Zhixiong Liu, Fangkun Liu, Yu Zeng

引用次数: 0

Comparing analgesic effects of temporal interference stimulation on ventral posterolateral thalamus and high-definition transcranial alternating current stimulation on sensorimotor cortex during sustained experimental pain.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-18 DOI: 10.1016/j.brs.2025.03.013

Tianzhe Jia, Jiahui Xia, Chuan Zhang, Baijintao Sun, Kai Yuan, Tian Liu, Xiaoxue Xu, Jixin Liu

引用次数: 0

Case evidence of connectivity-guided intermittent theta burst stimulation for the treatment of autism spectrum disorder.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-17 DOI: 10.1016/j.brs.2025.03.010

Li-Xia Yuan, Dan-Dan Chen, Wen-Qiang Dong, Chen Yang, Hong-Fei Zhang, Yi-Bing Wang, Jing-Song Tang, Xian-Wei Che, Robin F H Cash, Yu-Feng Zang, Wei Chen

引用次数: 0

Evaluating the Efficacy of Repetitive Anodal Transcranial Direct Current Stimulation on Cognitive Fatigue in Long COVID: A Randomized Controlled Trial.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-17 DOI: 10.1016/j.brs.2025.03.011

Magdalene Mischke, Tino Zaehle

引用次数: 0

Vagus Nerve Stimulation Therapy for Treatment-Resistant PTSD.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-15 DOI: 10.1016/j.brs.2025.03.007

M B Powers, Hays Sa, Rosenfield D, Porter Al, Gallaway Hl, Chauvette Gv, Smits Jaj, A M Warren, Douglas M, R Naftalis, Wigginton Jg, Foreman M, Kilgard Mp, Rennaker Rl

{"title":"Vagus Nerve Stimulation Therapy for Treatment-Resistant PTSD.","authors":"M B Powers, Hays Sa, Rosenfield D, Porter Al, Gallaway Hl, Chauvette Gv, Smits Jaj, A M Warren, Douglas M, R Naftalis, Wigginton Jg, Foreman M, Kilgard Mp, Rennaker Rl","doi":"10.1016/j.brs.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.007","url":null,"abstract":"Background: Posttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. This approach is premised on coupling prolonged exposure therapy, a first-line evidence-based cognitive behavioral therapy that directs changes within fear networks, with concurrent delivery of short bursts of vagus nerve stimulation (VNS), which enhance synaptic plasticity.Methods: We performed a first-in-human prospective open-label early feasibility study (EFS) using a next-generation miniaturized system to deliver VNS therapy in nine individuals with moderate to severe treatment-resistant PTSD. All individuals received a standard 12-session course of prolonged exposure therapy combined with VNS. Assessments were performed before, 1 week after, and 1, 3, and 6 months after the completion of therapy.Clinicaltrials: gov registration: NCT04064762.Results: VNS therapy resulted in significant, clinically-meaningful improvements in multiple metrics of PTSD symptoms and severity compared to baseline (CAPS-5, PCL-5, and HADS all p < 0.001 after therapy). These benefits persisted at 6 months after the cessation of therapy, suggesting lasting improvements. All participants showed loss of PTSD diagnosis after completing treatment. No serious or unexpected device-related adverse events were observed.Conclusions: These findings provide a demonstration of the safety and feasibility of VNS therapy for PTSD and highlight the potential of this approach. Collectively, these support the validation of VNS therapy for PTSD in a rigorous randomized controlled trial.","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optogenetic stimulation of cell bodies versus axonal terminals generate comparable activity and functional connectivity patterns in the brain.

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-14 DOI: 10.1016/j.brs.2025.03.006

Li-Ming Hsu, Domenic H Cerri, Regina M Carelli, Yen-Yu Ian Shih

引用次数: 0

MRgFUS pallidothalamic tractotomy following GPi DBS in a patient with refractory hemichorea: A case report. MRgFUS 苍白球丘脑束切开术治疗难治性偏盲患者的 GPi DBS：病例报告。

IF 7.6 1区医学

Brain Stimulation Pub Date : 2025-03-13 DOI: 10.1016/j.brs.2025.03.009

Kyoungwon Baik, Seongwoo Lee, Chan-Nyoung Lee, Kun-Woo Park, Jin Woo Chang

引用次数: 0