Brain Stimulation最新文献

{"title":"Epidural spinal cord stimulation for the management of orthostatic hypotension in Parkinson's disease: A case report.","authors":"Xue Zhu, Yuyan Tan, Zhuokun Gu, Yuchao Yang, Ningyuan Wang, Qianyi Yin, Sijia Huang, Zhengyu Lin, Peng Huang, Dianyou Li, Andrei Krassioukov, Jun Liu","doi":"10.1016/j.brs.2025.07.011","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.011","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Integrated MRI-Guided rTMS Protocol for Motor and Language Recovery.","authors":"Ye Zhang, Wencong Liang, Nan Zhou, Hongzhe Pan, Yufeng Zang, Ruochen Zhao, Yeyun Lu, Daming Wang","doi":"10.1016/j.brs.2025.07.010","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of stimulation artifacts in high-density Neuropixels recordings using sample clock-synchronized stimulation pulses.","authors":"Kantapon Pum Wiboonsaksakul, Dale C Roberts, Kathleen E Cullen","doi":"10.1016/j.brs.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Application of a Human Stereotactic System for Image-Guided Deep Brain Stimulation Neurosurgery in a Swine Model.","authors":"Kristen M Scheitler, Juan M Rojas-Cabrera, Sara A Vettleson-Trutza, Sheng-Ta Tsai, Guillermo K Pons-Monnier, Mohamed M El-Gohary, Ron Scheer, Youngjong Kwak, Damiano G Barone, Charles D Blaha, Tyler S Oesterle, Hojin Shin, Kendall H Lee, Yoonbae Oh","doi":"10.1016/j.brs.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigeminal Nerve Stimulation as a Semi-Active Control Condition in TMS Clinical Trials: Evidence From Heart-Brain Coupling and Clinical Outcomes.","authors":"Martijn Arns, Nolan Williams, Jonathan Downar, Aleksandra Dojnov, John Coetzee, Roberto Goya-Maldonado","doi":"10.1016/j.brs.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.004","url":null,"abstract":"<p><p>The inertness of sham controls in transcranial magnetic stimulation (TMS) studies, particularly those involving Transcutaneous Electrical Nerve Stimulation (TENS), remains controversial. Using heart-brain coupling (HBC) as a frontal-vagal engagement measure, we analyzed pilot data and data from two placebo-controlled accelerated intermittent theta burst stimulation (aiTBS) trials (combined N=100). Active-TMS induced significantly stronger HBC compared to sham in both studies, with the effect size for TENS-sham considerably attenuated, and significantly stronger HBC for TENS-sham relative to SAINT-sham (d=0.9). HBC in the TENS-sham group was associated with clinical improvement (d=1.12), reflecting antidepressant effects of trigeminal nerve stimulation. These findings suggest TENS-sham should be seen as a semi-active control condition, also controlling for trigeminal nerve stimulation, resulting in downstream vagal and cortical engagement and thus controlling for this non-specific effect of TMS. Future studies should be aware of this semi-active effect and conduct power-analyses accordingly, modifying the expected effect size. Furthermore, HBC could be used to titrate the intensity of TENS-stimulation to minimize semi-active effects.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the need of individually optimizing temporal interference stimulation of human brains due to inter-individual variability.","authors":"Tapasi Brahma, Alexander Guillen, Jeffrey Moreno, Abhishek Datta, Yu Huang","doi":"10.1016/j.brs.2025.07.006","DOIUrl":"10.1016/j.brs.2025.07.006","url":null,"abstract":"<p><strong>Introduction: </strong>Transcranial temporal interference stimulation (TI, TIS, or tTIS), also known as interferential stimulation (IFS), is able to focally stimulate deep brain regions, provided it is properly optimized. We previously presented an algorithm for optimizing TI using two arrays of electrodes and showed that it can achieve more focal stimulation compared to optimized high-definition transcranial electrical stimulation (HD-TES) and conventional optimized TI using two pairs of electrodes, especially in the deep brain areas such as the hippocampus. However, those modeling studies were only performed on an averaged head (MNI152 template) and three individual heads without exploring inter-individual variability. Existing TI works in the literature mostly utilize a common (possibly optimized) montage of two pairs of electrodes on different individual heads without considering inter-individual variability.</p><p><strong>Material and method: </strong>Here we aim to study the inter-individual variability of optimized TI by applying the same optimization algorithms on N = 25 heads using their individualized head models. Specifically, we compared the focality achieved by different stimulation techniques at six different regions of interest (ROI; right hippocampus, left dorsolateral prefrontal cortex, left motor cortex, right amygdala, right caudate, and left thalamus) under both individually optimized and unoptimized montages. We also conducted numerical sensitivity analysis on the individual optimization and performed phantom recordings to test our models.</p><p><strong>Results: </strong>As expected, there is a variability in focality achieved by TI of up to 1.2 cm at the same ROI across subjects due to inter-individual differences in the head anatomy and tissue conductivity. We show that optimized TI using two arrays of electrodes achieves higher focality than that from optimized HD-TES at the same level of modulation intensity at 5 of the 6 ROIs. Compared to using a common montage either optimized from the MNI152 template or from the literature, individually optimized TI using two pairs of electrodes improves the focality by up to 4.4 cm, and by up to 1.1 cm if using two arrays of electrodes. Focality achieved by the individual optimization is sensitive to random changes and can vary up to 9.3 cm due to the non-lienarity of TI physics. Experimental recordings on a head phantom confirms the drop in TI stimulation strength when using unoptimized montages as predicted by our in silico models.</p><p><strong>Conclusion: </strong>This work demonstrates the need of individually optimizing TI to target deep brain areas, and advocates against using a common head model and montage for TI modeling and experimental studies.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing control conditions for entraining neural oscillations using rhythmic TMS.","authors":"Runhao Lu, Isabelle Woods Rogan, Alexandra Woolgar","doi":"10.1016/j.brs.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral metabolic rate of oxygen is correlated to treatment effect of electroconvulsive therapy in patients with depression.","authors":"Christoffer Cramer Lundsgaard, André Beyer Mathiassen, Henrik Bo Wiberg Larsson, Poul Videbech, Krzysztof Gbyl, Mark Bitsch Vestergaard","doi":"10.1016/j.brs.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.005","url":null,"abstract":"<p><strong>Background: </strong>Neurobiological understanding of the antidepressant mechanisms of electroconvulsive therapy (ECT) is important to advance the treatment. ECT may work by improving depression-related alterations in the cerebral oxygen metabolism.</p><p><strong>Methods: </strong>21 in-patients with depression treated with an ECT series were examined 1) within two days before, and 2) a few days (median = 4 days) after the last ECT session. Depression severity was assessed by the six-item Hamilton Depression Rating Scale (HDRS-6). Magnetic resonance imaging (MRI) was used to measure 1) global cerebral blood flow (CBF) by phase contrast mapping technique and 2) global cerebral metabolic rate of oxygen (CMRO₂) by measuring cerebral extraction of oxygen (A-V.O₂) using susceptibility-based oximetry. Statistical analyses were performed using multiple linear regression, adjusting for age and gender.</p><p><strong>Results: </strong>ECT relieved depressive symptoms from HDRS-6 = 13.9 to 5.2 (p < 0.001), as expected. A larger increase in CMRO₂ after ECT was correlated with a better treatment effect (0.5% reduction in HDRS-6 per 1 % increase in CMRO₂, adjusted R² = 0.24, p = 0.026). The effect was driven by both higher A-V.O₂ and increased CBF. Before ECT, an abnormal decoupling between CMRO₂ and CBF was observed, which was normalized after the treatment (adjusted R² = 0.17, p = 0.03).</p><p><strong>Conclusions: </strong>The treatment effect of ECT for depression was associated with increased CMRO₂. Furthermore, ECT restored the normal coupling between CBF and CMRO₂. The results suggest that the cerebral oxygen metabolism may be abnormally altered in patients with depression and ECT restores such dysfunction.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-Optical Mapping Reveals Distributed Suppression of Cortical Sensory Responses After Optogenetic Silencing.","authors":"Ambrosone Manuel, Montagni Elena, Resta Francesco, Ulivi Tommaso, Curti Lorenzo, Polverini Federica, Mazzamuto Giacomo, Mannaioni Guido, Masi Alessio, Pavone Francesco Saverio, Allegra Mascaro Anna Letizia","doi":"10.1016/j.brs.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.brs.2025.07.003","url":null,"abstract":"<p><strong>Significance: </strong>We designed a novel all-optical tool to simultaneously silence neuronal activity at arbitrary sites on the dorsal cortex, and monitor the consequences of the manipulation. Optogenetic inhibition of primary sensory regions determined short and long-term dampening of the sensory response across a distributed cortical network.</p><p><strong>Introduction: </strong>Many fundamental processes of brain computation, such as sensory perception and motor control, heavily rely on the mesoscopic dynamics of activity across the cerebral cortex. Manipulating mesoscale activity and observing its effects across multiple brain regions is crucial for understanding the causal link between cortical dynamics and behavior.</p><p><strong>Objective: </strong>The goal of this study was to develop a novel all-optical system that allows inhibition of excitatory neurons while simultaneously monitoring cortical responses at arbitrary sites across the entire dorsal cortex of mice.</p><p><strong>Methods: </strong>We combined wide-field imaging and optogenetics to create a mesoscale all-optical approach, enabling simultaneous monitoring and manipulation of cortical activity using light. Intravenous injection of two PHP.eB AAVs enabled the whole-brain co-expression of the red-shifted calcium indicator jRCaMP1b and the inhibitory actuator stGtACR2, with stable expression over several weeks. This system was calibrated, and the effects of inhibition on sensory responses were tested.</p><p><strong>Results: </strong>Increasing laser power progressively reduced spontaneous activity at the site of irradiation. A single 5-second pulse on the barrel field cortex significantly decreased the amplitude of sensory-evoked responses, not only in the stimulated region but across the entire stimulated hemisphere.</p><p><strong>Conclusions: </strong>This novel all-optical system enables targeted inhibition while concurrently monitoring mesoscale cortical activity. It provides insights into the dynamics of cortical circuits and offers a milestone for investigating the causal links between neuronal activity and behavior. Future research can use this tool to address sensory responsiveness impairments in neurological and neuropsychiatric disorders.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Relating TMS measures of GABAergic and Cholinergic signalling to attention” [Brain Stimul 18 (1) (2025) 507–508]","authors":"Polytimi Frangou ,&nbsp;Lauryn Foster ,&nbsp;Fabio Ferrandes ,&nbsp;Shea Heaney ,&nbsp;Barbara Robinson ,&nbsp;Naqib Rahimi ,&nbsp;Yasmin Ratcliffe ,&nbsp;Charlotte Stagg","doi":"10.1016/j.brs.2025.05.110","DOIUrl":"10.1016/j.brs.2025.05.110","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 4","pages":"Page 1240"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}