Brain Stimulation最新文献

{"title":"A shift towards more precision: Addressing the profound implications of brain shift in model-based planning for ultrasonic brain stimulation.","authors":"Franz Roman Schmid, Julia Sophia Crone","doi":"10.1016/j.brs.2025.02.013","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.013","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of noninvasive neuromodulation combined with rapid, short-duration self-image stimuli in body dysmorphic disorder.","authors":"Wan-Wa Wong, D Rangaprakash, Joel P Diaz-Fong, Hayden J Peel, Reza Tadayonnejad, Andrew F Leuchter, Jamie D Feusner","doi":"10.1016/j.brs.2025.02.016","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.016","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards accredited clinical training in brain stimulation: Proceedings from the Brain Stimulation Subspecialty Summits.","authors":"Shan H Siddiqi, Leo Chen, Nicholas T Trapp, Noreen Bukhari-Parlakturk, Joseph J Taylor, Aaron D Boes, Joshua C Brown, Tracy Barbour, Joan A Camprodon, Michael D Fox, Brian H Kopell, Carlene MacMillan, Alfonso Fasano, Robert S Fisher, Ziad Nahas, Gonzalo J Revuelta, Patricio Riva-Posse, John D Rolston, Katherine Scangos, Mouhsin M Shafi, Andrew H Smith, Joshua Wong, Casey H Halpern, Helen S Mayberg, Nolan R Williams","doi":"10.1016/j.brs.2025.02.012","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.012","url":null,"abstract":"<p><p>The rapid development and clinical use of brain stimulation has renewed debates about whether to define and accredit a pathway for clinical subspecialty training. To address this, the Brain Stimulation Subspecialty Summits (BraSSS) were convened in 2023 and 2024, featuring international leaders in brain stimulation across psychiatry, neurology, neurosurgery, psychology, and neuroscience. Both meetings included two days of lectures and debates focused on clinical content, emerging science, and educational standards. The 2023 meeting was held at Brigham & Women's Hospital and Harvard University, where 54 attendees reached a consensus that the subspecialty is adequately developed to warrant formal recognition and initiated debates regarding the name and scope of the subspecialty. The 2024 meeting was held at Stanford University, where 56 attendees developed a content outline, organized committees, and reached a consensus to form an independent society focused on developing and maintaining unbiased accreditation standards. \"Brain stimulation\" was chosen democratically as the name of the subspecialty. Clinicians from multiple primary specialties may enter this subspecialty training track. While individual programs may have a specific area of focus (e.g. interventional psychiatry or epilepsy), our expectation is that accredited brain stimulation programs will provide training experiences that cross specialties and stimulation modalities. Several potential unintended consequences were discussed, and plans were developed to address them. Overall, subspecialty recognition was deemed to be beneficial to the brain stimulation field, with a goal to launch an associated society and start the process of accrediting existing US and Canadian programs in 2025.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Ultra-ultrabrief and Ultrabrief Pulse Widths in right unilateral Electroconvulsive Therapy: A Randomized Trial.","authors":"Jana Žaludová Heidingerová, Jakub Albrecht, Martin Anders, Daniel Divácký, Gabriela Jirečková, Thai Le Hong, Tadeáš Mareš, Václav Čapek, Harold A Sackeim, Jozef Buday","doi":"10.1016/j.brs.2025.02.017","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.017","url":null,"abstract":"<p><strong>Background: </strong>Ultrabrief stimulation in electroconvulsive therapy (ECT) using a 0.25 or 0.30 ms pulse width markedly reduces the charge required to reach the seizure threshold (ST) and cognitive side effects. It is not known whether further reduction of pulse width to 0.15 ms is advantageous.</p><p><strong>Methods: </strong>Thirty-seven patients were randomized to ST titration at the first session applying right unilateral (RUL) ECT with either a 0.15 or 0.30 ms pulse width and were titrated again in the second session using the alternative pulse width. All subsequent treatments used the pulse width applied in the second titration session, administering RUL ECT, starting at 6xST. The primary outcome was difference between the pulse widths in ST at the two titration sessions. Exploratory analyses examined differences in seizure duration and postictal time to recover orientation (TRO), averaged across all ECT sessions from the third onwards. Other exploratory analyses examined clinical improvement and retrograde amnesia for autobiographical information and other neuropsychological functions following the ECT course.</p><p><strong>Results: </strong>In the first titration session, ST was significantly lower with the 0.15 ms than 0.30 ms pulse width. ST significantly increased when re-titrating with the 0.30 ms pulse width and significantly decreased when re-titrating with a 0.15 ms pulse width. There were no differences between the pulse width groups in clinical improvement, TRO, or neuropsychological measures.</p><p><strong>Conclusions: </strong>Ultra-ultrabrief stimulation with a 0.15 ms pulse width is more efficient in seizure induction than a 0.30 ms pulse width. Comprehensive studies should determine whether ultra-ultrabrief stimulation replaces ultrabrief stimulation as a default parameter for ECT.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big non-invasive brain stimulation data (Big NIBS data): An open-access platform and repository for NIBS data.","authors":"Daniel T Corp, Hannah G K Bereznicki, Michael P Barham, Gillian M Clark, Benjamin J Chadwick, Saksham Jain, Hourieh Khalajzadeh, Alvaro Pascual-Leone, Peter G Enticott","doi":"10.1016/j.brs.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.011","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEP Status Revisited: Potential Value of the MEP Trichotomy to Distinguish Arm Motor Behavior.","authors":"Isha Vora, Baothy P Huynh, David J Lin, Teresa J Kimberley","doi":"10.1016/j.brs.2025.02.014","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.014","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed inhibition of corticospinal excitability by the thalamocortical sleep spindle.","authors":"Umair Hassan, Prince Okyere, Milad Amini Masouleh, Christoph Zrenner, Ulf Ziemann, Til Ole Bergmann","doi":"10.1016/j.brs.2025.02.015","DOIUrl":"https://doi.org/10.1016/j.brs.2025.02.015","url":null,"abstract":"<p><p>Thalamocortical sleep spindles, i.e., oscillatory bursts at ∼12-15 Hz of waxing and waning amplitude, are a hallmark feature of non-rapid eye movement (NREM) sleep and believed to play a key role in memory reactivation and consolidation. Generated in the thalamus and projecting to neocortex and hippocampus, they are phasically modulated by neocortical slow oscillations (<1 Hz) and in turn phasically modulate hippocampal sharp-wave ripples (>80 Hz). This hierarchical cross-frequency nesting, where slower oscillations group faster ones into certain excitability phases, may enable phase-dependent plasticity in the neocortex, and spindles have thus been considered windows of plasticity in the sleeping brain. However, the assumed phasic excitability modulation had not yet been demonstrated for spindles. Utilizing a recently developed real-time spindle detection algorithm, we applied spindle phase-triggered transcranial magnetic stimulation (TMS) to the primary motor cortex (M1) hand area to characterize the corticospinal excitability profile of spindles via motor evoked potentials (MEP). MEPs showed net suppression during spindles, driven by a \"pulse of inhibition\" during its falling flank with no inhibition or facilitation during its peak, rising flank, or trough. This unidirectional (\"asymmetric\") modulation occurred on top of the general sleep-related inhibition during spindle-free NREM sleep and did not extend into the refractory post-spindle periods. We conclude that spindles exert \"asymmetric pulsed inhibition\" on corticospinal excitability. These findings and the developed real-time spindle targeting methods enable future studies to investigate the causal role of spindles in phase-dependent synaptic plasticity and systems memory consolidation during sleep by repetitively targeting relevant spindle phases.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of vagus nerve stimulation in children with drug resistant epilepsy are driven by early benefit","authors":"Karim Mithani ,&nbsp;Farbod Niazi ,&nbsp;Hosni Abu Alhasan ,&nbsp;Hrishikesh Suresh ,&nbsp;Leeor Yefet ,&nbsp;Ivanna Yau ,&nbsp;Lyndsey McRae ,&nbsp;James T. Rutka ,&nbsp;Ayako Ochi ,&nbsp;Hiroshi Otsubo ,&nbsp;Elizabeth Donner ,&nbsp;Vann Chau ,&nbsp;Puneet Jain ,&nbsp;George M. Ibrahim","doi":"10.1016/j.brs.2025.02.010","DOIUrl":"10.1016/j.brs.2025.02.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 246-248"},"PeriodicalIF":7.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of high-dose and personalized TBS on post-stroke cognitive impairment: A randomized controlled trial","authors":"Jianxun Ren ,&nbsp;Wenlong Su ,&nbsp;Ying Zhou ,&nbsp;Kaiyue Han ,&nbsp;Ruiqi Pan ,&nbsp;Xinyu Duan ,&nbsp;Jiajie Liu ,&nbsp;Haitao Lu ,&nbsp;Ping Zhang ,&nbsp;Wei Zhang ,&nbsp;Jian Sun ,&nbsp;Mengying Ding ,&nbsp;Yafei Zhu ,&nbsp;Wuxiang Xie ,&nbsp;Jianting Huang ,&nbsp;Hao Zhang ,&nbsp;Hesheng Liu","doi":"10.1016/j.brs.2025.02.009","DOIUrl":"10.1016/j.brs.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairments are prevalent among stroke patients, impacting independent living. While intermittent theta burst stimulation (iTBS) shows potential for rehabilitation, the efficacy of the commonly-used doses remains unsatisfactory.</div></div><div><h3>Objective</h3><div>To investigate the efficacy, dose-dependent effect, and safety of high-dose iTBS targeting the individualized frontoparietal cognitive network (FCN) for post-stroke cognitive recovery.</div></div><div><h3>Methods</h3><div>In a randomized, sham-controlled, three-arm trial, patients with post-stroke cognitive impairment (PSCI) received 15 days of high-dose (3600 pulses/day), standard low-dose (1200 pulses/day) as an active control, or sham iTBS targeting the individualized FCN, alongside cognitive training. Primary outcome measured changes in global cognition via the Montreal Cognitive Assessment (MoCA). Secondary measures included MoCA response rates and score changes in the Wechsler Memory Scale, Wechsler Adult Intelligence Scale, and Mini-Mental State Examination.</div></div><div><h3>Results</h3><div>Of forty-five randomized participants, forty-one (8 women; mean [SD] age, 58.63 [8.64] years) were analyzed. Personalized targeting improved focality by 33.0 % over the standard F3 target in E-field analysis. Both high-dose and standard low-dose groups showed significant improvements in MoCA. Importantly, the high-dose group demonstrated superior cognitive recovery over both the active control group (estimated difference = 2.50, <em>p</em> = 0.0339, 95 % CI = 0.15–4.84) and the sham control group (estimated difference = 4.29, <em>p</em> = 0.0001, 95 % CI = 1.99–6.60), indicating a superior effect of high-dose stimulation for cognitive recovery. Similar high-dose and dose-dependent effects were observed in other secondary outcomes, suggesting consistent effects on the memory, intelligence, and mental state. No serious adverse events occurred.</div></div><div><h3>Conclusions</h3><div>This study highlights the efficacy and safety of high-dose iTBS targeting the individualized FCN for post-stroke cognitive recovery.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Pages 249-258"},"PeriodicalIF":7.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Low-intensity focused ultrasound (LIFU) for the treatment of post-traumatic headache (PTH) in veterans: A feasibility study” [Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, vol. 17 (2024), pg. 1290–1292/No. 6]","authors":"Byung C. Yoon ,&nbsp;John P. Coetzee ,&nbsp;Xiaojian Kang ,&nbsp;Rajenpreet Brar ,&nbsp;Molly Timmerman ,&nbsp;Odette Harris ,&nbsp;Esmeralda Madrigal ,&nbsp;Maheen M. Adamson","doi":"10.1016/j.brs.2025.01.019","DOIUrl":"10.1016/j.brs.2025.01.019","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 2","pages":"Page 211"},"PeriodicalIF":7.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}