Brain Stimulation最新文献

{"title":"Thermal bioeffects considerations for transcranial focused ultrasound associated neurodegeneration","authors":"Alon Gilad , Shy Shoham","doi":"10.1016/j.brs.2026.103102","DOIUrl":"10.1016/j.brs.2026.103102","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103102"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From nerve to brain: External trigeminal stimulation as a novel neuroprotective strategy for acute ischemic stroke","authors":"Rui Zhao , Chen Cheng , Xingyu Liu , Jiale Li , Rui Zhao , Jiaxin Ye , Xiao Zeng , Jin-Bo Sun , Peng Liu , Hui Qiao , Xue-Juan Yang","doi":"10.1016/j.brs.2026.103112","DOIUrl":"10.1016/j.brs.2026.103112","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103112"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dithering suppresses half-harmonic neural synchronisation to photic stimulation in humans","authors":"Benoit Duchet ,&nbsp;Samini Subramaniam ,&nbsp;Alexander Greenway ,&nbsp;Shenghong He ,&nbsp;Nicholas Shackle ,&nbsp;Alek Pogosyan ,&nbsp;Timothy Denison ,&nbsp;Andrew Sharott ,&nbsp;Huiling Tan ,&nbsp;Rafal Bogacz","doi":"10.1016/j.brs.2026.103111","DOIUrl":"10.1016/j.brs.2026.103111","url":null,"abstract":"<div><h3>Background:</h3><div>While entraining neural rhythms using brain stimulation has been suggested as a therapeutic mechanism to normalise brain activity in conditions such as depression, chronic pain, or Alzheimer’s disease, periodic stimulation can also inadvertently entrain brain rhythms at sub- and superharmonics of the stimulation frequency, which could lead to deleterious effects. Slightly jittering stimulation pulses (called “dithering”) was previously proposed on the basis of mathematical modelling to selectively entrain a target neural rhythm while avoiding harmonic entrainment. In this study, we investigated the potential of dithering in humans.</div></div><div><h3>Methods:</h3><div>We recorded EEG in healthy adults during photic stimulation (light flicker) under periodic, dithered, reduced-strength, and control conditions. Synchronisation was quantified using spectral power and the phase-locking value.</div></div><div><h3>Results:</h3><div>We showed that dithering suppresses half-harmonic synchronisation relative to perfectly periodic flicker, and that dithering affects synchronisation at the stimulation frequency less than at the half-harmonic. This was also the case for a periodic condition with reduced stimulation strength, as predicted by theory. Furthermore, we demonstrated using synthetic data and modelling that the half-harmonic responses observed in participants cannot be explained by the superposition of evoked responses (even when modulated at the half-harmonic frequency), and are better matched by a minimal oscillator model.</div></div><div><h3>Conclusion:</h3><div>Our findings are consistent with half-harmonic EEG synchronisation in response to photic stimulation predominantly reflecting half-harmonic entrainment rather than the summation of evoked responses, and with dithering being an effective strategy to suppress subharmonic entrainment without reducing the energy delivered.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103111"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circuit-informed targeting for psychiatric comorbidity in depression: An accelerated TMS pilot study","authors":"Lauren L. Sanderson ,&nbsp;Anjali Chandra ,&nbsp;Emma Jones ,&nbsp;Leanna Bomer ,&nbsp;Natalie Hall ,&nbsp;Marina R. Kare ,&nbsp;David Lawson ,&nbsp;Nicole Chiulli ,&nbsp;Ryan D. Webler ,&nbsp;Sheena R. Baratono ,&nbsp;Irene Gonsalvez ,&nbsp;Stanley Lyndon ,&nbsp;Michael D. Fox ,&nbsp;Shan H. Siddiqi ,&nbsp;Joseph J. Taylor","doi":"10.1016/j.brs.2026.103106","DOIUrl":"10.1016/j.brs.2026.103106","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103106"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Just a caffeine-blocker? Questioning new proposed core mechanisms of ECT","authors":"Johannes Knabbe ,&nbsp;Alexander Sartorius","doi":"10.1016/j.brs.2026.103108","DOIUrl":"10.1016/j.brs.2026.103108","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103108"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epileptic spike and waves induce transient lapses of neural excitability","authors":"G. Furregoni ,&nbsp;F.M. Zauli ,&nbsp;S. Valenzano ,&nbsp;E.P. Mikulan ,&nbsp;M. Rosanova ,&nbsp;M. Massimini ,&nbsp;A. Pigorini ,&nbsp;S. Russo","doi":"10.1016/j.brs.2026.103100","DOIUrl":"10.1016/j.brs.2026.103100","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103100"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No seizures observed with 100-Hz intermittent theta burst TMS applied to the dorsolateral prefrontal cortex","authors":"Aaron D. Boes ,&nbsp;Benjamin D. Pace ,&nbsp;Holly Van Den Beldt ,&nbsp;Yasser El-Hattab ,&nbsp;Andrew Foster ,&nbsp;Anthony Pugianto ,&nbsp;Nicholas T. Trapp","doi":"10.1016/j.brs.2026.103107","DOIUrl":"10.1016/j.brs.2026.103107","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103107"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lack of efficacy of high-definition transcranial direct current stimulation in the five-day training of a difficult visual search task","authors":"Gorana Pobric,&nbsp;Stephen Ball,&nbsp;Mica Komarnyckyj,&nbsp;Jason R. Taylor,&nbsp;Johan Hulleman","doi":"10.1016/j.brs.2026.103110","DOIUrl":"10.1016/j.brs.2026.103110","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103110"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driving theta-gamma oscillations modulates short interval intracortical inhibition: a tACS-TMS study","authors":"Camille Lasbareilles ,&nbsp;Valentina Mancini ,&nbsp;Alek Pogosyan ,&nbsp;Helen Zhang ,&nbsp;Charlotte Austin ,&nbsp;Huiling Tan ,&nbsp;Charlotte J. Stagg","doi":"10.1016/j.brs.2026.103115","DOIUrl":"10.1016/j.brs.2026.103115","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103115"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A minimally invasive floating-wire interface for transcranial deep brain stimulation","authors":"Vishal Jain ,&nbsp;Mats Forssell ,&nbsp;Pulkit Grover ,&nbsp;Maysamreza Chamanzar","doi":"10.1016/j.brs.2026.103096","DOIUrl":"10.1016/j.brs.2026.103096","url":null,"abstract":"<div><h3>Background</h3><div>Noninvasive neuromodulation technologies have advanced considerably. Yet, precise and focal activation of deep brain regions remains challenging due to the rapid attenuation of electric fields through the scalp, skull and brain tissue.</div></div><div><h3>Objective</h3><div>We present FLOATES (FLOAting Transcranial Electrical Stimulation), a novel approach that employs an untethered wire implanted in the brain which passively relays currents injected transcranially from the brain surface to deep brain regions, achieving focused stimulation deep within the brain.</div></div><div><h3>Methods</h3><div>We validated FLOATES through a combination of simulations, benchtop testing, and in vivo rodent studies. The benchtop experiments confirmed the ability to relay the field across the floating wire. Rodent studies demonstrated capability to stimulate deep brain regions in vivo.</div></div><div><h3>Results</h3><div>Our simulation and benchtop testing results indicate that FLOATES can deliver significantly higher electric fields to subcortical regions compared to conventional transcranial stimulation approaches. Further in vivo results demonstrate stimulation of the deep subthalamic nucleus to evoke motor responses in limbs and demonstrate a significantly lower motor threshold compared to transcranial stimulation. Finite element simulations reveal that the efficiency of FLOATES depends on several key parameters including input field strength, wire length and diameter, exposed electrode area, electrode impedance, and tip geometry. Simulations using a human-sized head model suggest that strong enough electric fields for deep brain stimulation can be achieved with safe current levels injected through the scalp.</div></div><div><h3>Conclusion</h3><div>Together, these results establish a theoretical and experimental foundation for FLOATES as a minimally invasive and spatially precise brain stimulation platform for modulating deep neural circuits implicated in neuropsychiatric and movement disorders.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"19 3","pages":"Article 103096"},"PeriodicalIF":8.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}