Brain Stimulation最新文献

{"title":"A Comparative Analysis of Technical Data: At-Home vs. In-Clinic Application of Transcranial Direct Current Stimulation in Depression.","authors":"Ulrike Vogelmann, Matthias Stadler, Aldo Soldini, Kai-Yen Chang, Miaoxi Chen, Lucia Bulubas, Esther Dechantsreiter, Christian Plewnia, Andreas Fallgatter, Berthold Langguth, Claus Normann, Lukas Frase, Peter Zwanzger, Thomas Kammer, Carlos Schönfeldt-Lecuona, Daniel Kamp, Malek Bajbouj, Alexander Hunold, Severin Schramm, Josef Priller, Ulrich Palm, Leigh Charvet, Daniel Keeser, Gerrit Burkhardt, Frank Padberg","doi":"10.1016/j.brs.2025.05.103","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.103","url":null,"abstract":"<p><strong>Objective: </strong>The application of transcranial direct current stimulation (tDCS) at home for the treatment of depression and other neuropsychiatric disorders presents both significant opportunities and inherent challenges. Ensuring safety and maintaining high-quality stimulation are paramount for the efficacy and safety of at-home tDCS. This study investigates tDCS quality based on its technical parameters as well as safety of at-home and in-clinic tDCS applications comparing the data from two randomized controlled trials in patients with major depressive disorder.</p><p><strong>Methods: </strong>We analyzed 229 active stimulation sessions from the HomeDC study (at-home tDCS) and 835 sessions from the DepressionDC study (in-clinic tDCS). Notably, five adverse events (skin lesions) were reported exclusively in the at-home cohort, highlighting the critical need for enhanced safety protocols in unsupervised environments.</p><p><strong>Results: </strong>The analysis revealed a significant difference in the average variability of impedances between at-home and in-clinic applications (F1,46 = 4.96, p = .031, η² = .097). The at-home tDCS sessions exhibited higher impedance variability (M = 837, SD = 328) compared to in-clinic sessions (M = 579, SD = 309). Furthermore, at-home tDCS sessions resulting in adverse events (AEs) were associated with significantly higher average impedances than sessions without such issues.</p><p><strong>Conclusion: </strong>The study demonstrates that monitoring the technical parameters of at-home tDCS used in this study is essential. However, it may be not sufficient for ensuring safety and promptly detecting or preventing adverse events. Quality control protocols including digital training and monitoring techniques should be systematically developed and tested for a reliable and safe application of at-home tDCS therapies.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Nerve, Two Stories: Low- and High-Frequency External Trigeminal Nerve Stimulation (eTNS) Shape Cortical and Autonomic Sleep Dynamics Differently.","authors":"Chen Cheng, Xiangmiao Peng, Yuchen Sun, Yunyun Jiao, Xiao Zeng, Jin-Bo Sun, Xue-Juan Yang, Wei Qin","doi":"10.1016/j.brs.2025.05.104","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.104","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta-frequency subthalamic nucleus stimulation increases decision threshold.","authors":"Rachel C Cole, Nadja R Ging Jehli, Juan Vivanco Suarez, Jeremy D Greenlee, Jan R Wessel, Arturo I Espinoza, Johnson Zhang, James F Cavanagh, Nandakumar S Narayanan","doi":"10.1016/j.brs.2025.05.105","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.105","url":null,"abstract":"<p><strong>Introduction: </strong>Executive functions are often impaired in patients with Parkinson's disease (PD), and these deficits can be predicted by decreased frontal cortical 4-8 Hz theta activity that is associated with cognitive control. Previous work has shown that stimulating the subthalamic nucleus (STN) at theta frequencies via deep-brain stimulation (DBS) can improve cognitive control. Here we tested the neurocomputational hypothesis that stimulating STN theta activity increases decision thresholds, supporting more deliberate responding and nuanced adaptation under task trials that require cognitive control.</p><p><strong>Methods: </strong>We tested 15 patients with PD receiving STN DBS at standard therapeutic frequencies ∼130 Hz and at 4 Hz while performing a Simon reaction-time task and applying computational diffusion decision modeling analyses to quantify the latent cognitive characteristic of response cautiousness via the well-established model parameter known as the decision threshold. This computational analyses better accounts for the speed-accuracy trade off when making deliberate choices.</p><p><strong>Results: </strong>We found that ∼130-Hz STN DBS decreased decision thresholds in line with our prior work, and we report new results showing that 4-Hz STN DBS increased decision thresholds.</p><p><strong>Conclusions: </strong>These findings extend our knowledge of how the STN controls decision thresholds. Future work will study the STN's role in motor and cognitive control and how stimulating this region may modulate cognition in PD.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated anxiosomatic circuit TMS: An open-label pilot study in Chinese participants with a treatment-resistant anxiety-related disorder.","authors":"Huiru Cui, Ryan D Webler, Lihua Xu, Zhenying Qian, Yingying Tang, Tianhong Zhang, Chunbo Li, Shan H Siddiqi, Jijun Wang","doi":"10.1016/j.brs.2025.05.102","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.102","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Cerebellar TMS Targeting: MRI-Neuronavigation and Landmark-Based Approaches Assessed by E-Field Modeling.","authors":"Vridhi Rohira, Xavier Corominas-Teruel, Salim Ouarab, Traian Popa, Cécile Gallea, Antoni Valero-Cabré, Martina Bracco","doi":"10.1016/j.brs.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pragmatic Accelerated Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder.","authors":"Noah S Philip, F Andrew Kozel, Elizabeth A Walter, Emily K McMillan, Bo Dehm Wicklund, Zachary D Zuschlag, Michelle R Madore","doi":"10.1016/j.brs.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial of Anodal transcranial Direct Current Stimulation (A-tDCS) and Olfactory Training in persistent COVID-19 anosmia.","authors":"Lucilla Vestito, Marta Ponzano, Laura Mori, Carlo Trompetto, Fabio Bandini","doi":"10.1016/j.brs.2025.04.023","DOIUrl":"https://doi.org/10.1016/j.brs.2025.04.023","url":null,"abstract":"<p><strong>Background: </strong>Persistent anosmia due to COVID-19 affects approximately 20 million individuals worldwide, with a serious detrimental effect on their quality of life. Effective treatments remain lacking, with olfactory training (OT) being supported by some evidence of benefit. We implemented a double-blind, randomized, controlled trial (RCT) combining OT with Anodal transcranial Direct Current Stimulation (A-tDCS) with the aim to confirm the encouraging results of a preliminary study by our group. We also evaluated the long-term effectiveness of this intervention at both one- and six-months post-treatment assessments.</p><p><strong>Methods: </strong>This RCT involved 52 patients with persistent hypo/anosmia due to COVID-19. Participants were randomly assigned to undergo OT coupled with either A-tDCS targeting the Prefrontal Cortex (PFC) (experimental group, n=35), or sham stimulation (placebo group, n=17) for two weeks (10 sessions). The end point was the change in smell function from the baseline, as assessed by subjective and objective scores (VAS and Sniffin' Sticks test or SST).</p><p><strong>Results: </strong>The experimental group demonstrated a significant amelioration of both smell measures. Specifically, the mean VAS-smell increased from 2.56 to 4.70 (p < 0.001) and the mean SST from 6.97 to 9.69 (p < 0.001). Seventy-seven percent of patients in the experimental group significantly improved, with 63% achieving a complete recovery. No olfactory amelioration was observed in the placebo group. The significant smell improvement was sustained at both follow-up assessments.</p><p><strong>Conclusion: </strong>This RCT demonstrates that combining A-tDCS with concurrent OT is able to restore the olfactory function in individuals suffering from persistent COVID-19 anosmia, with a durable effect. This safe and inexpensive treatment can therefore represent a suitable and widespread option for millions of individuals. These positive results also support the hypothesis that the brain olfactory networks are involved in the pathophysiology of COVID-19 anosmia.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site-Specific Neuronal and Motor Effects of Short-Term Intermittent Burst Deep Brain Stimulation in Non-Human Primates.","authors":"Sana Amoozegar, Lvpiao Zheng, Ziling Luo, Kit Acedillo, Kanon Nakajima, Adele L DeNicola, Luke A Johnson, Jerrold L Vitek, Aryn H Gittis, Jing Wang","doi":"10.1016/j.brs.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigeminal semilunar ganglion stimulation modulates default mode network connectivity in trigeminal neuralgia.","authors":"Bowen Chang, Jiaming Mei, Chi Xiong, Manli Jiang, Chaoshi Niu","doi":"10.1016/j.brs.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.001","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling deep brain stimulation effects in native patient or template space - Does it matter?","authors":"Julianna Pijar, Lukas L Goede, Konstantin Butenko, Lauren A Hart, Savir Madan, Till A Dembek, Garance M Meyer, Nanditha Rajamani, Ningfei Li, Andrea A Kühn, Andreas Horn, Clemens Neudorfer","doi":"10.1016/j.brs.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}