Brain Stimulation最新文献

{"title":"An open-source user interface for real-time ultra-fast solving of electric fields around segmented deep brain stimulation electrodes.","authors":"Kaylee R Henry, Mark Ingersoll, William Wartman, Fuchang Jiang, Dexuan Tang, Laleh Golestanirad, Sergey N Makaroff","doi":"10.1016/j.brs.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.brs.2024.11.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of white matter variability in TMS neuromodulatory effects","authors":"Mar Martín-Signes ,&nbsp;Pablo Rodríguez-San Esteban ,&nbsp;Cristina Narganes-Pineda ,&nbsp;Alfonso Caracuel ,&nbsp;José Luís Mata ,&nbsp;Elisa Martín-Arévalo ,&nbsp;Ana B. Chica","doi":"10.1016/j.brs.2024.11.006","DOIUrl":"10.1016/j.brs.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial Magnetic Stimulation (TMS) is a widely used tool to explore the causal role of focal brain regions in cognitive processing. TMS effects over attentional processes are consistent and replicable, while at the same time subjected to individual variability. This individual variability needs to be understood to better comprehend TMS effects, and most importantly, its clinical applications.</div></div><div><h3>Objective</h3><div>This study aimed to explore the role of white matter variability in TMS neuromodulatory effects on behavior in healthy participants (N = 50).</div></div><div><h3>Methods</h3><div>Participants completed an attentional task in which orienting and alerting cues preceded near-threshold targets. Continuous Theta Burst Stimulation (cTBS) was applied over the left frontal eye field (FEF) or an active vertex condition. White matter was explored with diffusion-weighted imaging tractography and Tract-Based Spatial Statistics (TBSS).</div></div><div><h3>Results</h3><div>Behaviorally, TMS over the left FEF slowed down reaction times (especially in the alerting task), impaired accuracy in the objective task, and reduced the proportion of seen targets (as compared to the vertex condition). Attentional effects increased, overall, when TMS was applied to the left FEF as compared to the vertex condition. Correlations between white matter and TMS effects showed i) reduced TMS effects associated with the microstructural properties of long-range white matter pathways such as the superior longitudinal fasciculus (SLF), and interhemispheric fibers of the corpus callosum (CC), and ii) increased TMS effects in participants with high integrity of the CC connecting the stimulated region with the opposite hemisphere. Additionally, variability in attentional effects was also related to white matter, showing iii) increased alerting effects in participants with low integrity of association, commissural, and projection fibers, and iv) increased orienting effects in participants with high integrity of the right SLF III.</div></div><div><h3>Conclusion</h3><div>All these observations highlight the importance of taking into account individual variability in white matter for the understanding of cognitive processing and brain neuromodulation effects.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1265-1276"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial temporal interference subthalamic stimulation for treating motor symptoms in Parkinson's disease: A pilot study","authors":"Chenhao Yang ,&nbsp;Yongxin Xu ,&nbsp;Yichao Du,&nbsp;Xiaonan Shen,&nbsp;Tingting Li,&nbsp;Nan Chen,&nbsp;Yulian Zhu,&nbsp;Lu Li,&nbsp;Lingyan Huang,&nbsp;Jiaojiao Lü,&nbsp;Zhenyu Qian,&nbsp;Zhen Wang,&nbsp;Junhong Zhou,&nbsp;Ulf Ziemann,&nbsp;Chencheng Zhang,&nbsp;Yu Liu","doi":"10.1016/j.brs.2024.10.012","DOIUrl":"10.1016/j.brs.2024.10.012","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1250-1252"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent optogenetic motor mapping of multiple limbs in awake mice reveals cortical organization of coordinated movements","authors":"Nischal Khanal ,&nbsp;Jonah A. Padawer-Curry ,&nbsp;Trevor Voss ,&nbsp;Kevin A. Schulte ,&nbsp;Annie R. Bice ,&nbsp;Adam Q. Bauer","doi":"10.1016/j.brs.2024.10.010","DOIUrl":"10.1016/j.brs.2024.10.010","url":null,"abstract":"<div><h3>Background</h3><div>Motor mapping allows for determining the macroscopic organization of motor circuits and corresponding motor movement representations on the cortex. Techniques such as intracortical microstimulation (ICMS) are robust, but can be time consuming and invasive, making them non-ideal for cortex-wide mapping or longitudinal studies. In contrast, optogenetic motor mapping offers a rapid and minimally invasive technique, enabling mapping with high spatiotemporal resolution. However, motor mapping has seen limited use in tracking 3-dimensonal, multi-limb movements in awake animals. This gap has left open questions regarding the underlying organizational principles of motor control of coordinated, ethologically-relevant movements involving multiple limbs.</div></div><div><h3>Objective</h3><div>Our first objective was to develop Multi-limb Optogenetic Motor Mapping (MOMM) to concurrently map motor movement representations of multiple limbs with high fidelity in awake mice. Having established MOMM, our next objective was determine whether maps of coordinated and ethologically-relevant motor output were topographically organized on the cortex.</div></div><div><h3>Methods</h3><div>We combine optogenetic stimulation with a deep learning driven pose-estimation toolbox, DeepLabCut (DLC), and 3-dimensional triangulation to concurrently map motor movements of multiple limbs in awake mice.</div></div><div><h3>Results</h3><div>MOMM consistently revealed cortical topographies for all mapped features within and across mice. Many motor maps overlapped and were topographically similar. Several motor movement representations extended beyond cytoarchitecturally defined somatomotor cortex. Finer articulations of the forepaw resided within gross motor movement representations of the forelimb. Moreover, many cortical sites exhibited concurrent limb coactivation when photostimulated, prompting the identification of several cortical regions harboring coordinated and ethologically-relevant movements.</div></div><div><h3>Conclusions</h3><div>The cortex appears to be topographically organized by motor programs, which are responsible for coordinated, multi-limbed, and behavior-like movements.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1229-1240"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static transcranial magnetic stimulation does not alter cortical excitability in patients with amyotrophic lateral sclerosis on riluzole","authors":"Caspar Stephani,&nbsp;Helena Krämer,&nbsp;Ivan Chakalov,&nbsp;Mathias Bähr,&nbsp;Walter Paulus,&nbsp;Andrea Antal,&nbsp;Jan Christoph Koch","doi":"10.1016/j.brs.2024.10.013","DOIUrl":"10.1016/j.brs.2024.10.013","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1244-1246"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different stimulation targets of rTMS modulate specific triple-network and hippocampal-cortex functional connectivity","authors":"Luyao Wang ,&nbsp;Wenjing Hu ,&nbsp;Huanxin Wang ,&nbsp;Ziyan Song ,&nbsp;Hua Lin ,&nbsp;Jiehui Jiang","doi":"10.1016/j.brs.2024.11.003","DOIUrl":"10.1016/j.brs.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Repetitive transcranial magnetic stimulation (rTMS) is widely applied to treat Alzheimer's disease (AD). Various treatment targets are currently being explored in clinical research. However, target diversity can result in considerable heterogeneity.</div></div><div><h3>Objective</h3><div>This study aimed to investigate whether different rTMS targets can enhance cognitive domains by modulating functional connectivity (FC) of the hippocampus (HIP) and triple network, which comprises the salience network (SN), central executive network (CEN), and default mode network (DMN).</div></div><div><h3>Methods</h3><div>We enrolled 63 patients with AD, of whom 48 and 15 underwent rTMS targeting the left dorsolateral prefrontal cortex (dlPFC) and the bilateral angular gyrus (ANG), respectively. We examined the network-level FC differences within the triple-network before and after treatment. Additionally, we utilized HIP as a seed for voxel-level analysis. We compared the similarities and differences in the effects of dlPFC and ANG rTMS.</div></div><div><h3>Results</h3><div>rTMS targeting the dlPFC primarily influenced the FC of the CEN, whereas rTMS targeting the ANG primarily influenced the SN and DMN. Moreover, the right temporal lobe within the DMN exhibited reduced FC with the left HIP following both therapies. The results of least absolute shrinkage and selection operator (LASSO) analysis indicated that hippocampal-cortex FC played a dominant role in the therapeutic effect. The observed FC changes significantly correlated with improvements in multiple cognitive scales.</div></div><div><h3>Conclusion</h3><div>rTMS targeting different regions affected the FC of specific networks. Both stimulation targets modulate the FC of hippocampal-cortex to influence therapeutic outcomes. Classification of patients based on damaged networks can further inform subsequent treatment strategies.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1256-1264"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response regarding: Frontal HD-tACS enhances behavioral and EEG biomarkers of vigilance in continuous attention task","authors":"Nigel Gebodh,&nbsp;Marom Bikson","doi":"10.1016/j.brs.2024.11.004","DOIUrl":"10.1016/j.brs.2024.11.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1277-1278"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of accelerated high-dose and low-dose magnetic stimulation for freezing of gait in Parkinson's disease","authors":"Jinmei Sun,&nbsp;Xin Chen,&nbsp;Jinying Han,&nbsp;Mengqi Wang,&nbsp;Ziye Zhao,&nbsp;Lili Hu,&nbsp;Zhenxiong Yuliu,&nbsp;Gong-Jun Ji ,&nbsp;Kai Wang ,&nbsp;Panpan Hu","doi":"10.1016/j.brs.2024.10.011","DOIUrl":"10.1016/j.brs.2024.10.011","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1247-1249"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evoked resonant neural activity in the pallidal-subthalamic circuit during dual lead deep brain stimulation in DYT-TOR1A dystonia: A case study","authors":"Kara A. Johnson,&nbsp;Filipe P. Sarmento,&nbsp;Joshua K. Wong,&nbsp;Justin D. Hilliard,&nbsp;Kelly D. Foote,&nbsp;Coralie de Hemptinne","doi":"10.1016/j.brs.2024.11.001","DOIUrl":"10.1016/j.brs.2024.11.001","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1253-1255"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and pilot efficacy of self-applied home-based cognitive training and brain stimulation: A randomized-controlled trial","authors":"Merle Rocke,&nbsp;Anna E. Fromm,&nbsp;Nora Jansen,&nbsp;Friederike Thams,&nbsp;Catalina Trujillo-Llano,&nbsp;Ulrike Grittner,&nbsp;Daria Antonenko ,&nbsp;Agnes Flöel","doi":"10.1016/j.brs.2024.10.009","DOIUrl":"10.1016/j.brs.2024.10.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1241-1243"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}