Brain Stimulation最新文献

{"title":"Aperiodic activity as a biomarker of seizures and neuromodulation.","authors":"David Satzer, Lesley C Kaye, Steven G Ojemann, Daniel R Kramer, John A Thompson","doi":"10.1016/j.brs.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.022","url":null,"abstract":"<p><strong>Introduction: </strong>Mounting evidence suggests the efficacy of neuromodulation for epilepsy is mediated by network remodeling and neural state. Epilepsy network related pathophysiology has been associated with variation in the aperiodic exponent, which describes the inverse relationship between frequency and power and has been linked to synaptic-level processes. This study sought to assess relationships between periodic and aperiodic activity, disease state, and responsive stimulation.</p><p><strong>Methods: </strong>Chronic intracranial EEG was recorded from 13 patients undergoing responsive neurostimulation for epilepsy. Recordings containing clinician-annotated seizures, stimulation triggered by device-detected interictal epileptiform activity (IEA), and stimulation-free interictal periods were analyzed. Multidien IEA cycles were identified, and recordings were classified by cycle phase. Power spectra were parameterized into periodic and aperiodic components using an established algorithm.</p><p><strong>Results: </strong>The aperiodic exponent was larger during seizures and pre-stimulation intervals than stimulation-free interictal recordings, and decreased following stimulation. A rise in aperiodic exponent was observed in the 12 hours preceding seizures. Larger aperiodic exponent was observed during the rising phase of multidien IEA cycles. Periodic alpha and beta power were larger during seizures, pre-stimulation intervals, and high-risk (rising and/or peak) IEA cycle phases, whereas periodic theta and gamma power exhibited variable relationships. Periodic power did not change after stimulation or in the hours before seizures for any studied frequency band.</p><p><strong>Conclusions: </strong>The aperiodic exponent was positively related to instantaneous and multidien disease state severity and negatively related to therapeutic stimulation. Aperiodic activity may emerge as a practical biomarker of disease state and treatment response to guide neuromodulation for epilepsy.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Direct Current Stimulation and Methylphenidate interact to increase Cognitive Persistence as a Core Component of Metacontrol: Evidence from aperiodic activity analyses.","authors":"Yang Gao, Anna Helin Koyun, Veit Roessner, Ann-Kathrin Stock, Moritz Mückschel, Lorenza Colzato, Bernhard Hommel, Christian Beste","doi":"10.1016/j.brs.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.024","url":null,"abstract":"<p><strong>Background: </strong>Metacontrol is the ability to optimize the balance between cognitive persistence and flexibility. Recent research points to aperiodic EEG activity as a neurophysiological marker for metacontrol and its modulations. However, the causal link between metacontrol and aperiodic activity is still unclear.</p><p><strong>Objective: </strong>We provide mechanistic insights into the neurobiological foundations of metacontrol and the means to enhance it. We evaluated the interplay of anodal transcranial direct current stimulation (atDCS) and Methylphenidate (MPH), both of which are known to alter cortical noise, a factor that can be measured by aperiodic exponents derived from EEG data.</p><p><strong>Methods: </strong>We examined the impact of right inferior frontal (midpoint between electrodes FC4 and F8) 20 minutes offline atDCS at 2-mA and MPH administration, both separately and combined, on aperiodic EEG activity while healthy adult participants (N=98) performed a Go/NoGo task. We used the FOOOF (fitting oscillations & one over f) algorithm to examine aperiodic activity.</p><p><strong>Results: </strong>We obtained an interaction between atDCS stimulation and MPH administration, indicating that atDCS is effective in reducing aperiodic neural activity (i.e., increased aperiodic exponents) when being combined with MPH administration.</p><p><strong>Conclusion: </strong>Aperiodic neural activity can be modulated through pharmacology-tuned atDCS. atDCS and MPH rely on overlapping neurobiological mechanisms. Metacontrol depending on aperiodic neural activity can be modulated through combined atDCS-MPH stimulation. Hence, atDCS and MPH are suitable tools to achieve an exogenous modulation of metacontrol bias and aperiodic exponents are indices to demonstrate the effectiveness of such tools.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating brain network dynamics in state-dependent stimulation: a concurrent Electroencephalography and Transcranial Magnetic Stimulation study using Hidden Markov Models.","authors":"Saeed Makkinayeri, Roberto Guidotti, Alessio Basti, Mark W Woolrich, Chetan Gohil, Mauro Pettorruso, Maria Ermolova, Risto J Ilmoniemi, Ulf Ziemann, Gian Luca Romani, Vittorio Pizzella, Laura Marzetti","doi":"10.1016/j.brs.2025.03.020","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.020","url":null,"abstract":"<p><strong>Background: </strong>Systems neuroscience studies have shown that baseline brain activity can be categorized into large-scale networks (resting-state-networks, RNSs), with influence on cognitive abilities and clinical symptoms. These insights have guided millimeter-precise selection of brain stimulation targets based on RSNs. Concurrently, Transcranial Magnetic Stimulation (TMS) studies revealed that baseline brain states, measured by EEG signal power or phase, affect stimulation outcomes. However, EEG dynamics in these studies are mostly limited to single regions or channels, lacking the spatial resolution needed for accurate network-level characterization.</p><p><strong>Objective: </strong>We aim at mapping brain networks with high spatial and temporal precision and to assess whether the occurrence of specific network-level-states impact TMS outcome. To this end, we will identify large-scale brain networks and explore how their dynamics relates to corticospinal excitability.</p><p><strong>Methods: </strong>This study leverages Hidden Markov Models to identify large-scale brain states from pre-stimulus source space high-density-EEG data collected during TMS targeting the left primary motor cortex in twenty healthy subjects. The association between states and fMRI-defined RSNs was explored using the Yeo atlas, and the trial-by-trial relation between states and corticospinal excitability was examined.</p><p><strong>Results: </strong>We extracted fast-dynamic large-scale brain states with unique spatiotemporal and spectral features resembling major RSNs. The engagement of different networks significantly influences corticospinal excitability, with larger motor evoked potentials when baseline activity was dominated by the sensorimotor network.</p><p><strong>Conclusions: </strong>These findings represent a step forward towards characterizing brain network in EEG-TMS with both high spatial and temporal resolution and underscore the importance of incorporating large-scale network dynamics into TMS experiments.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced zero-phase synchronization as a potential neural code for optimized visuomotor integration.","authors":"Kirstin-Friederike Heise, Geneviève Albouy, Nina Dolfen, Ronald Peeters, Dante Mantini, Stephan P Swinnen","doi":"10.1016/j.brs.2025.03.019","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.019","url":null,"abstract":"<p><strong>Background: </strong>Goal-directed behavior requires the integration of information from the outside world and internal (somatosensory) sources about our own actions. Expectations (or 'internal models') are generated from prior knowledge and constantly updated based on sensory feedback. This optimized information integration ('predictive coding') results in a global behavioral advantage of anticipated action in the presence of uncertainty. Our goal was to probe the effect of phase entrainment of the sensorimotor mu-rhythm on visuomotor integration.</p><p><strong>Methods: </strong>Participants received transcranial alternating current stimulation over bilateral motor cortices (M1) while performing a visually-guided force adjustment task during functional magnetic resonance imaging.</p><p><strong>Results: </strong>Inter-hemispheric zero-phase entrainment resulted in effector-specific modulation of performance precision and effector-generic minimization of force signal complexity paralleled by BOLD activation changes in bilateral caudate and increased functional connectivity between the right M1 and contralateral putamen, inferior parietal, and medial temporal regions. While effector-specific changes in performance precision were associated with contralateral caudate and hippocampal activation decreases, only the global reduction in force signal complexity was associated with increased functional M1 connectivity with bilateral striatal regions.</p><p><strong>Conclusion: </strong>We propose that zero-phase synchronization represents a neural mode of optimized information integration related to internal model updating within the recursive perception-action continuum associated with predictive coding.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Effects of Spaced Transcranial Direct Current Stimulation in Major Depression.","authors":"Véronique Desbeaumes Jodoin, Emma Bousseau, Maxime Couture, Paul Lespérance, Jean-Philippe Miron","doi":"10.1016/j.brs.2025.03.016","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.016","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): a role for microglia.","authors":"Paolo d'Errico, Iris Früholz, Melanie Meyer-Luehmann, Andreas Vlachos","doi":"10.1016/j.brs.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.012","url":null,"abstract":"<p><p>Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to modulate neocortical excitability, with expanding applications in neurological and psychiatric disorders. However, the cellular and molecular mechanisms underlying its effects, particularly the role of microglia-the resident immune cells of the central nervous system-remain poorly understood. This review synthesizes recent findings on how different rTMS protocols influence microglial function under physiological conditions and in disease models. Emerging evidence indicates that rTMS modulates microglial activation, promoting neuroprotective and plasticity-enhancing processes not only in models of brain disorders, such as Alzheimer's and Parkinson's disease, but also in healthy neural circuits. While much of the current research has focused on the inflammatory profile of microglia, critical aspects such as activity-dependent synaptic remodeling, phagocytic activity, and process motility remain underexplored. Given the substantial heterogeneity of microglial responses across brain regions, age, and sex, as well as their differential roles in health and disease, a deeper understanding of their involvement in rTMS-induced plasticity is essential. Future studies should integrate selective microglial manipulation and advanced structural, functional, and molecular profiling techniques to clarify their causal involvement. Addressing these gaps will be pivotal in optimizing rTMS protocols and maximizing its therapeutic potential across a spectrum of neurological and neuropsychiatric conditions.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated iTBS with a personalised targeting method to treat negative symptoms of schizophrenia: A randomized controlled trial.","authors":"Yunyi Han, Fang Jin, Jimmy Lee, Wenpeng Hou, Xue Yang, Yiming Zhang, Yueying Zhang, Xuefeng Lu, Zhimin Wang, Qijing Bo, Zhengyi Yang, Fuchun Zhou, Tianzi Jiang, Chuanyue Wang","doi":"10.1016/j.brs.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.014","url":null,"abstract":"<p><strong>Background: </strong>The efficacy of non-invasive brain stimulation in ameliorating schizophrenia's negative symptoms remains to be validated. The mesocortical pathway, mostly comprising the ventral tegmental area (VTA) and prefrontal cortex, is the core neural circuit underlying negative symptoms. This study aimed to assess the clinical and biological effects of accelerated intermittent theta burst stimulation (iTBS) targeted to the dorsolateral prefrontal cortex (dlPFC), guided by personalised dlPFC-VTA functional connectivity (FC).</p><p><strong>Methods: </strong>Eighty schizophrenia patients with predominant negative symptoms received 40 sessions of either active (n = 40) or sham (n = 40) accelerated iTBS (1800 pulses) in two weeks, targeting the region of the left dlPFC most functionally correlated with the VTA. Clinical and cognitive follow-ups occurred at week 4, 8, and 12. The primary outcome was the alteration in PANSS negative symptom (PANSS-NS) scores at week 4, while secondary outcomes included additional clinical, cognitive assessments and neuroimaging alterations.</p><p><strong>Results: </strong>At week 4, the active group showed a significant reduction in PANSS-NS compared to the sham group, with a significant group × time interaction effect (P < 0.001, mean difference = 4.10, Cohen's d = 0.83). At week 2, compared to the sham group, the active group exhibited reduced left temporal middle gyrus (TMG) (r = -0.29, p = 0.01) activation and FC between the VTA and left TMG (r = -0.34, p = 0.003), and both were negatively correlated with PANSS-NS changes in both groups.</p><p><strong>Conclusion: </strong>Accelerated iTBS targeting the personalised region determined by dlPFC-VTA FC is an effective intervention to alleviate negative symptoms of schizophrenia.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor treating fields may improve the prognosis of patients with lung cancer brain metastases.","authors":"Junsong Peng, Liyang Zhang, Yinghua Wu, Ling Chen, Zhixiong Liu, Fangkun Liu, Yu Zeng","doi":"10.1016/j.brs.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.003","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing analgesic effects of temporal interference stimulation on ventral posterolateral thalamus and high-definition transcranial alternating current stimulation on sensorimotor cortex during sustained experimental pain.","authors":"Tianzhe Jia, Jiahui Xia, Chuan Zhang, Baijintao Sun, Kai Yuan, Tian Liu, Xiaoxue Xu, Jixin Liu","doi":"10.1016/j.brs.2025.03.013","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.013","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case evidence of connectivity-guided intermittent theta burst stimulation for the treatment of autism spectrum disorder.","authors":"Li-Xia Yuan, Dan-Dan Chen, Wen-Qiang Dong, Chen Yang, Hong-Fei Zhang, Yi-Bing Wang, Jing-Song Tang, Xian-Wei Che, Robin F H Cash, Yu-Feng Zang, Wei Chen","doi":"10.1016/j.brs.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.brs.2025.03.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}