Brain Stimulation最新文献

{"title":"Note of concern regarding the sources of scientific evidence used to justify the Reclassification of Non-Invasive Brain Stimulation (NIBS) Devices without an intended medical purpose into Class III.","authors":"Andrea Antal, Alexander T Sack, Til Ole Bergmann, Jovana Bjekić, Saša R Filipović, Ana Ganho, Vera Moliadze, Michael A Nitsche, Simone Rossi, Teresa Schuhmann, Hartwig Siebner, Walter Paulus, Chris Baeken","doi":"10.1016/j.brs.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.brs.2025.01.012","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of electroconvulsive therapy in adolescents with a depressive episode (depressive, bipolar disorders): a naturalistic retrospective cohort study.","authors":"Xuequan Zhu, YuanZhen Wu, Xiongying Chen, Zizhao Feng, Jingjie Xu, Ling Zhang, Xu Chen, Gang Wang","doi":"10.1016/j.brs.2025.01.016","DOIUrl":"https://doi.org/10.1016/j.brs.2025.01.016","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Intensity Focused Ultrasound Stimulation in Stroke: A Phase I Safety & Feasibility Trial.","authors":"Ziping Huang, Charalambos C Charalambous, Mengyue Chen, Taewon Kim, Estate Sokhadze, Allen Song, Sin-Ho Jung, Shashank Shekhar, Jody A Feld, Xiaoning Jiang, Wuwei Feng","doi":"10.1016/j.brs.2025.01.015","DOIUrl":"https://doi.org/10.1016/j.brs.2025.01.015","url":null,"abstract":"<p><strong>Objective: </strong>We aim to determine the maximum safe spatial-peak pulse-average intensity (I_SPPA) of low-intensity focused ultrasound stimulation (LIFUS) in stroke patients and explore its effect on motor learning and corticospinal excitability.</p><p><strong>Methods: </strong>We adopted the classic 3+3 design to escalate I_SPPA (estimated in-vivo transcranial value) from 0, 1, 2, 4, 6, to 8 W/cm². Stopping rules were pre-defined: 2^nd-degree scalp burn, clinical seizure, new lesion on diffusion-weighted imaging or major reduction in apparent diffusion coefficient, and participant discontinuation due to any reason. We applied 12-minute LIFUS over the ipsilesional motor cortex while participants were concurrently practicing 3 blocks of a motor sequence learning (MSL) task using the affected hand. We measured MSL (response time) and corticospinal excitability (motor evoked potential) pre- and post-stimulation and compared MSL and corticospinal excitability between the LOW (0, 1, and 2 W/cm²) and HIGH (4, 6, and 8 W/cm²) groups.</p><p><strong>Results: </strong>I_SPPA was escalated to 8 W/cm² with 18 stroke participants without meeting the stopping rules. Compared to the LOW, more participants in the HIGH performed better on MSL (6/9 vs. 0/9, p = 0.009) and showed a sign of greater corticospinal excitability (7/9 vs. 5/9, p = 0.62).</p><p><strong>Interpretation: </strong>Our phase-I safety study suggests that one session of LIFUS up to 8 W/cm² I_SPPA is safe and feasible in stroke patients, and high intensity induces positive changes on both MSL and corticospinal excitability. The next logical step is to conduct a phase-II trial testing the efficacy of LIFUS and continuously monitoring its safety profiles.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous electrical stimulation enhances episodic memory encoding via a noradrenaline-attention network, with associated neuroinflammatory changes.","authors":"Elva Arulchelvan, Sven Vanneste","doi":"10.1016/j.brs.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.brs.2025.01.008","url":null,"abstract":"<p><strong>Background: </strong>Attention plays a central role in learning and memory processes. Prior research has demonstrated how goal-directed attention influences successful performance on both attention and working memory tasks. However, an important question remains about whether long-term memory outcomes can be reliably enhanced by targeting attention processes.</p><p><strong>Objective: </strong>To test the hypothesis that 40 Hz Non-invasive Transcutaneous Electrical Stimulation of the Greater Occipital Nerve (NITESGON) would enhance long-term memory encoding by upregulating theta activity in the dorsal attention network. We also hypothesized that this would be in association with upregulated noradrenaline activity and downregulated cytokine activity.</p><p><strong>Methods: </strong>In two double-blinded experiments, learning and memory were tested via a Swahili-English word-association task completed on 2 visits (separated by 1 week). 60 individuals were randomized to assess 40 Hz NITESGON's effect compared to active-control (1 Hz) or sham conditions. Before and after stimulation, rs-EEG assessed theta activity in the dorsal attention network, and saliva measures were collected incl. salivary alpha amylase (sAA; a proxy for noradrenaline activity) and cytokines (IL-6, IL-1β and TNF-α).</p><p><strong>Results: </strong>Participants receiving 40 Hz NITESGON learned and remembered more words than control or sham groups. There were no significant differences in consolidation between the groups. 40 Hz NITESGON was associated with increased theta activity in the dorsal attention network, and this activation was associated with enhanced learning but not memory performance. The 40 Hz NITESGON group had significantly upregulated sAA post-stimulation, with this associated with learning and memory (supporting a LC-NA mechanism). Modulation of IL-1β and TNF-α were not frequency specific. However, modulation of IL-6 was specific to 40 Hz and was associated with memory outcomes.</p><p><strong>Conclusion: </strong>40 Hz NITESGON can activate a noradrenaline - dorsal attention network, to facilitate goal-directed attention during encoding stages of a long-term memory task, in association with neuroinflammatory changes.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual Human Retina: Simulating Neural Signalling, Degeneration, and Responses to Electrical Stimulation.","authors":"Keith Ly, Michael L Italiano, Mohit N Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H Lovell, Socrates Dokos, Tianruo Guo","doi":"10.1016/j.brs.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.brs.2025.01.013","url":null,"abstract":"<p><strong>Introduction: </strong>Current brain-based visual prostheses pose significant challenges impeding adoption such as the necessarily complex surgeries and occurrence of more substantial side effects due to the sensitivity of the brain. This has led to much effort toward vision restoration being focused on the more approachable part of the brain - the retina. Here we introduce a novel, parameterized simulation platform that enables study of human retinal degeneration and optimization of stimulation strategies. The platform bears immense potential for patient-specific tailoring and serves to enhance artificial vision solutions for individuals with visual impairments.</p><p><strong>Material and method: </strong>Our virtual retina is developed using the software package, NEURON. This virtual retina platform supports large-scale simulations of over 10,000 neurons whilst upholding strong biological plausibility with multiple important visual pathways and detailed network properties. The comprehensive three-dimensional model includes photoreceptors, horizontal cells, bipolar cells, amacrine cells, and midget and parasol retinal ganglion cells, with comprehensive network connectivity across various eccentricities (1 mm to 5 mm from the fovea) in the human retina. The model is constructed using electrophysiology, immunohistology, and optical coherence tomography imaging data from healthy and degenerate human retinas. We validated our model by replicating numerous experimental observations from human and primate retina, with a particular focus on retinal degeneration.</p><p><strong>Result: </strong>We simulated interactions between diseased retinas and state-of-the-art retinal implants, shedding light on the limitations of commercial retinal prostheses. Our results suggested that appropriate stimulation settings with intraretinal prototype devices could leverage network-mediated activation to achieve activation mosaics more alike that of the retina's response to natural light, promoting the prospect of more naturalistic vision. Our study additionally highlights the importance of controlling inhibitory circuits in the retinal network to induce functionally relevant retinal activity.</p><p><strong>Conclusion: </strong>This study demonstrates the potential of this software package and highlights its utility as a valuable tool for engineers, scientists, and clinicians in the design and optimisation of retinal stimulation devices for both research and educational applications.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional MRI reveals brain activation patterns associated with optimization of spinal cord stimulation parameters in treating chronic pain.","authors":"Artur Vetkas, Cletus Cheyuo, Ajmal Zemmar, Brendan Santyr, Clement T Chow, Sriranga Kashyap, Benson Yang, Mia Mojica, Alexandre Boutet, Can Sarica, Jürgen Germann, Stefan Lang, Mohammad M Hajiabadi, Andrew Z Yang, Simon J Graham, Kâmil Uludağ, Anuj Bhatia, Andres M Lozano","doi":"10.1016/j.brs.2025.01.009","DOIUrl":"10.1016/j.brs.2025.01.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"173-175"},"PeriodicalIF":7.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sham response of schizophrenia and depression in intermittent theta burst stimulation trials: A meta-analysis.","authors":"Taro Kishi, Kenji Sakuma, Masakazu Hatano, Nakao Iwata","doi":"10.1016/j.brs.2025.01.010","DOIUrl":"10.1016/j.brs.2025.01.010","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"176-178"},"PeriodicalIF":7.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive transcranial magnetic stimulation for the treatment of suicidal ideation in a naturalistic setting.","authors":"Noah Stapper, Jordan Kohn, Lindsay Benster, Hadley Daniels, Vanessa Tello, Aashi Patel, Vidhi Oswal, Louise Stolz, Mohsen Poorganji, Yinming Sun, Zafiris J Daskalakis, Lawrence G Appelbaum, Cory R Weissman","doi":"10.1016/j.brs.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.brs.2025.01.005","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 1","pages":"141-143"},"PeriodicalIF":7.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-species characterization of transcranial ultrasound propagation.","authors":"Zhiwei Li, Hanwen Wang, Xiaoyu Zhang, Chengbiao Lu, Shouyang Yu, Bin Yu, Yingwei Li, Ke Zeng, Xiaoli Li","doi":"10.1016/j.brs.2025.01.007","DOIUrl":"10.1016/j.brs.2025.01.007","url":null,"abstract":"<p><strong>Background: </strong>Transcranial ultrasound stimulation (TUS) has shown promising prospects as a non-invasive neuromodulation technique for both animals and humans. However, ultrasonic propagation characteristics within the brain differ significantly from those in free space. There is currently a lack of comprehensive studies on the effects of skull thickness on focal point position, full width at half maximum (FWHM), and acoustic intensity.</p><p><strong>Objective: </strong>This study investigates the transcranial acoustic field characteristics of 500 kHz focused ultrasound, with a focus on the impact of skull thickness.</p><p><strong>Methods: </strong>The study combined finite element simulations to evaluate the effects of skull thickness on 500 kHz focused ultrasound with experimental investigations across multiple species (mouse, rat, pig, and human).</p><p><strong>Results: </strong>The simulation and experimental results indicate that the skull changes focal length (-4.4-4.7 mm) and axial focal region (-7.93-7.59 mm), and the skull causes significant attenuation of acoustic intensity, which increases with skull thickness. The attenuation rate of human skulls is greater than 80 %. We found that the skull thickness has little effect on focal point position (<0.9 mm) and focal region (<1.44 mm) in lateral and vertical directions.</p><p><strong>Conclusion: </strong>Skull thickness has great influence on focal length, axial focal region and acoustic intensity, but has little effect on focal point position and focal region in lateral and vertical directions. And improving axial spatial resolution is a potential method to reduce changes of axial focal region.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"164-172"},"PeriodicalIF":7.6,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprogramming of updated neurostimulators in chronically implanted patients with Parkinson's disease: A double-blind randomized controlled trial.","authors":"Alexandra Boogers, Maria Belen Justich, Marcela Montiel, Ibrahim Alhashyan, Sara Naghdlou, Srdjan Sumarac, Luka Milosevic, Andres M Lozano, Suneil K Kalia, Renato P Munhoz, Alfonso Fasano","doi":"10.1016/j.brs.2025.01.006","DOIUrl":"10.1016/j.brs.2025.01.006","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"138-140"},"PeriodicalIF":7.6,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}