Brain Stimulation最新文献

{"title":"Anodic stimulation of the subthalamic nucleus rescues cathodic stimulation-induced mood symptoms in Parkinson disease.","authors":"Alexander J Baumgartner, Lisa Hirt, Drew S Kern, John A Thompson","doi":"10.1016/j.brs.2025.05.005","DOIUrl":"10.1016/j.brs.2025.05.005","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemogenetic modulation in stroke recovery: A promising stroke therapy Approach.","authors":"Xinyuan Yu, Zhihong Jian, Lihong Dang, Xu Zhang, Peibang He, Xiaoxing Xiong, Yanping Feng, Ata Ur Rehman","doi":"10.1016/j.brs.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.003","url":null,"abstract":"<p><p>Stroke remains a leading cause of long-term disability and mortality worldwide, necessitating novel therapeutic strategies to enhance recovery. Traditional rehabilitation approaches, including physical therapy and pharmacological interventions, often provide limited functional improvement. Neuromodulation has emerged as a promising strategy to promote post-stroke recovery by enhancing neuroplasticity and functional reorganization. Among various neuromodulatory techniques, chemogenetics, particularly Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), offers precise, cell-type-specific, and temporally controlled modulation of neuronal and glial activity. This review explores the mechanisms and therapeutic potential of chemogenetic modulation in stroke recovery. Preclinical studies have demonstrated that activation of excitatory DREADDs (hM3Dq) in neurons located within the peri-infarct area or contralateral M1 has been shown to enhance neuroplasticity, facilitate axonal sprouting, and lead to improved behavioral recovery following stroke. Conversely, stimulation of inhibitory DREADDs (hM4Di) suppresses stroke-induced excitotoxicity, mitigates peri-infarct spreading depolarizations (PIDs), and modulates neuroinflammatory responses. By targeting specific neuronal and glial populations, chemogenetics enables phase-specific interventions-early inhibition to minimize damage during the acute phase and late excitation to promote plasticity during the recovery phase. Despite its advantages over traditional neuromodulation techniques, such as optogenetics and deep brain stimulation, several challenges remain before chemogenetics can be translated into clinical applications. These include optimizing viral vector delivery, improving ligand specificity, minimizing off-target effects, and ensuring long-term receptor stability. Furthermore, integrating chemogenetics with existing stroke rehabilitation strategies, including brain-computer interfaces and physical therapy, may enhance functional recovery by facilitating adaptive neuroplasticity. Future research should focus on refining chemogenetic tools to enable clinical application. By offering a highly selective, reversible, and minimally invasive approach, chemogenetics holds great potential for revolutionizing post-stroke therapy and advancing personalized neuromodulation strategies.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of dopaminergic transmission and brain activity by frontotemporal tDCS: A multimodal PET-MR imaging study.","authors":"Clara Fonteneau, Inés Merida, Jérome Redoute, Frédéric Haesebaert, Sophie Lancelot, Nicolas Costes, Marine Mondino, Jerome Brunelin","doi":"10.1016/j.brs.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.brs.2025.05.006","url":null,"abstract":"<p><strong>Background: </strong>Transcranial Direct Current Stimulation (tDCS) is a promising noninvasive intervention for schizophrenia, particularly when applied using a frontotemporal montage. Although significant clinical benefits have been reported, the variability in individual responses underscores the need for a more comprehensive understanding of its underlying neurophysiological mechanisms. Here, we used a simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) approach (PET-MR) to investigate the effects of frontotemporal tDCS on dopamine transmission, cerebral perfusion, and white matter microstructural integrity in healthy individuals.</p><p><strong>Methods: </strong>In a double-blind, two-arm, parallel group study, 30 healthy volunteers were randomly allocated to receive a single session of either active (n = 15) or sham (n = 15) frontotemporal tDCS. The stimulation session was delivered during simultaneous multimodal PET-MR imaging, which combined PET with the [¹¹C]raclopride radiotracer, Arterial Spin Labeling (ASL), and Diffusion Weighted Imaging.</p><p><strong>Results: </strong>PET [¹¹C]raclopride analysis revealed a significant reduction in Non-Displaceable Binding Potential in the left executive striatal subregion 15 min after tDCS in the active group, compared to both baseline and the sham group. This finding suggests that frontotemporal tDCS may induce an increase in dopamine release. ASL analysis showed that active tDCS may reduce cerebral blood flow in the precuneus compared to sham stimulation. No significant effects of tDCS were observed on white matter microstructural integrity.</p><p><strong>Conclusion: </strong>This study provides new insights into the neurophysiological mechanisms of frontotemporal tDCS, paving the way for the optimization of therapeutic strategies for patients with dysregulated cortico-subcortical dopamine systems.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated iTBS-Induced changes in resting-state functional connectivity correspond with cognitive improvement in amnestic MCI","authors":"Stephanie Aghamoosa ,&nbsp;Sara A. Nolin ,&nbsp;Andrew A. Chen ,&nbsp;Kevin A. Caulfield ,&nbsp;James Lopez ,&nbsp;Katrina Rbeiz ,&nbsp;Holly H. Fleischmann ,&nbsp;Olivia Horn ,&nbsp;Katrina Madden ,&nbsp;Michael Antonucci ,&nbsp;Gonzalo Revuelta ,&nbsp;Lisa M. McTeague ,&nbsp;Andreana Benitez","doi":"10.1016/j.brs.2025.04.012","DOIUrl":"10.1016/j.brs.2025.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Published results of our Phase I safety and feasibility trial of accelerated intermittent theta burst stimulation (a-iTBS) in mild cognitive impairment (MCI) due to Alzheimer's disease showed a large effect-size improvement in cognition.</div></div><div><h3>Objective</h3><div>Further demonstrate target engagement by identifying whether changes in local and network-level functional connectivity relate to the observed cognitive improvement.</div></div><div><h3>Methods</h3><div>Eighteen patients with MCI received 3-day a-iTBS (8 sessions/day) to the left dorsolateral prefrontal cortex at Beam F3 (14,400 total pulses) and completed MRI and cognitive testing at pre- and post-treatment. Based on electric field models, we selected 3 stimulated target regions of interest (ROIs) which belonged to the frontoparietal (FPN), default mode (DMN), and ventral attention (VAT) networks (3 target networks). Metrics of resting-state functional connectivity were computed at the ROI level (within-network degree: number of connections) and network level (segregation: strength of connectivity within-network relative to other networks). We correlated changes in cognition and connectivity of the target ROIs and networks; off-target ROI (primary visual) and networks served as negative controls.</div></div><div><h3>Results</h3><div>Improvements in cognition were associated with connectivity changes in the target ROIs and networks, but not in off-target negative controls. Positive associations were observed for degree of the l-DMN and segregation of target networks overall, with significant effects for DMN and VAT.</div></div><div><h3>Conclusion</h3><div>Cognitive improvement following a-iTBS in MCI may be attributable to local and network-level reconfigurations in functional connectivity. These findings will inform larger trials designed to further evaluate the neural mechanisms of a-iTBS for cognition in MCI.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 957-964"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low intensity rTMS in adolescent mice affects visuomotor behaviour with no impact on visual topography","authors":"Maitri Tomar ,&nbsp;Joseph JF Pow ,&nbsp;Marissa A Penrose-Menz ,&nbsp;Jamie L Beros ,&nbsp;Aleksandra Miljevic ,&nbsp;Bruno Meloni ,&nbsp;Jennifer Rodger","doi":"10.1016/j.brs.2025.04.017","DOIUrl":"10.1016/j.brs.2025.04.017","url":null,"abstract":"<div><h3>Background</h3><div>Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used as a therapeutic and experimental tool. It is FDA-approved for treating major depressive disorder in adults and has an excellent safety profile. rTMS is less well characterised in children but was recently approved as an augmentative treatment in adolescents (15–21 years). However, the adolescent brain is still undergoing structural and functional changes and the effect of rTMS on neurodevelopment is not understood.</div></div><div><h3>Objective</h3><div>In the present study we used a mouse model to assess the impact of low intensity (perifocal) rTMS (LI-rTMS) in the developing brain on visual system organisation and associated behavioural outcomes.</div></div><div><h3>Methods</h3><div>We used miniature coils to deliver LI-rTMS to the primary visual cortex (V1) in mice aged 28 days (∼12 human years), every day for two weeks (biomimetic high frequency stimulation, 10 min). We measured anatomical organisation of the corticocollicular and geniculocortical visual pathways, visuomotor behaviour, as well as V1 expression of markers of inhibition, excitation and inflammation (astrocytes and microglia) in LI-rTMS and sham treated groups.</div></div><div><h3>Results</h3><div>LI-rTMS did not alter the organisation of visual pathways, excitatory/inhibitory balance or cause overt inflammation in the brain but did result in a mild deficit in visuomotor behaviour. Our results suggest that LI-rTMS delivered during development may have network-wide effects impacting sensorimotor integration.</div></div><div><h3>Conclusion</h3><div>While we cannot rule out that changes in functional connectivity might be transient and/or beneficial in a disease context, our findings highlight that more clinical and preclinical studies are needed to validate the safety and mechanism of action of rTMS for children and adolescents.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 965-974"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous vagus nerve stimulation boosts accuracy during perceptual decision-making","authors":"Shiyong Su ,&nbsp;Thomas Vanvoorden ,&nbsp;Pierre Le Denmat ,&nbsp;Alexandre Zénon ,&nbsp;Clara Braconnier ,&nbsp;Julie Duque","doi":"10.1016/j.brs.2025.04.020","DOIUrl":"10.1016/j.brs.2025.04.020","url":null,"abstract":"<div><h3>Background</h3><div>The locus coeruleus-norepinephrine (LC-NE) system is a well-established regulator of behavior, yet its precise role remains unclear. Animal studies predominantly support a “gain” hypothesis, suggesting that the LC-NE system enhances sensory processing. In contrast, human studies have proposed an alternative “urgency” hypothesis, postulating that LC-NE primarily accelerates responses.</div></div><div><h3>Method</h3><div>To address this discrepancy, we administered transcutaneous vagus nerve stimulation (tVNS) in two experiments. In the first experiment (n = 22), we showed that 4-s tVNS trains reliably induced greater pupil dilation compared to SHAM condition, indicating increased LC-NE activity. In the second experiment (n = 21), we applied tVNS during a random dot motion task to assess its impact on perceptual decision-making.</div></div><div><h3>Result</h3><div>tVNS improved accuracy without affecting reaction times, which appears inconsistent with the “urgency” hypothesis. Exploratory drift-diffusion model analyses further support the “gain” hypothesis, revealing that tVNS increased the drift rate, indicative of enhanced evidence accumulation. Both accuracy and drift-rate improvements were most prominent following errors and especially pronounced in participants who exhibited post-error declines in these measures under SHAM.</div></div><div><h3>Conclusion</h3><div>Our findings align with the “gain” hypothesis, with tentative evidence suggesting that the impact of LC-NE activity adapts to task demands. Accordingly, tVNS showed the strongest effects in contexts prone to accuracy declines, possibly reflecting attentional disengagement, which points to a role of LC in mitigating lapses of attention.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 975-986"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous auricular vagus nerve stimulation for acquired immune deficiency syndrome patients with depressive symptoms: a pilot randomized clinical trial","authors":"Ningyi Zou ,&nbsp;Qing Zhou ,&nbsp;Zongshi Qin ,&nbsp;Liqin Ma ,&nbsp;Haibo Wang ,&nbsp;Li Su ,&nbsp;Sheharyar S. Baig ,&nbsp;Na Dong ,&nbsp;Fenxiang Li ,&nbsp;Shiqi Diao ,&nbsp;Jian Wang ,&nbsp;Chengjie Ma ,&nbsp;Peijing Rong ,&nbsp;Guojian Gao ,&nbsp;Shaoyuan Li","doi":"10.1016/j.brs.2025.04.022","DOIUrl":"10.1016/j.brs.2025.04.022","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 987-989"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep transcranial ultrasound stimulation using personalized acoustic metamaterials improves treatment-resistant depression in humans","authors":"David Attali ,&nbsp;Thomas Tiennot ,&nbsp;Thomas J. Manuel ,&nbsp;Maxime Daniel ,&nbsp;Alexandre Houdouin ,&nbsp;Philippe Annic ,&nbsp;Alexandre Dizeux ,&nbsp;Alexandre Haroche ,&nbsp;Ghita Dadi ,&nbsp;Adèle Henensal ,&nbsp;Mylène Moyal ,&nbsp;Alice Le Berre ,&nbsp;Cécile Paolillo ,&nbsp;Sylvain Charron ,&nbsp;Clément Debacker ,&nbsp;Maliesse Lui ,&nbsp;Sabrina Lekcir ,&nbsp;Rosella Mancusi ,&nbsp;Thierry Gallarda ,&nbsp;Tarek Sharshar ,&nbsp;Marion Plaze","doi":"10.1016/j.brs.2025.04.018","DOIUrl":"10.1016/j.brs.2025.04.018","url":null,"abstract":"<div><h3>Background</h3><div>Neuromodulation of deep brain regions has shown promise for treatment-resistant depression (TRD). However, it currently requires neurosurgical electrode implantation, posing significant risks and limiting widespread use while TRD affects around 100 million people worldwide. Low-intensity transcranial ultrasound stimulation (TUS) could allow precise and non-invasive deep neuromodulation, provided that the challenge of the defocusing effects of the skull is tackled.</div></div><div><h3>Objective/hypothesis</h3><div>Here, we present the development of a portable and neuronavigated TUS prototype based on the use of patient-specific metamaterials (metalens) that correct for skull-induced aberrations. We then present the first application of metalens-based Transcranial Ultrasound Stimulation (mTUS) in TRD. The primary objective was to assess the safety and efficacy of mTUS targeting on individual level specific white matter tracts of the subcallosal cingulate involved in TRD.</div></div><div><h3>Methods</h3><div>The safety and precision of this device was addressed through a series of numerical simulations and experimental measurements on <em>ex vivo</em> human skulls. Five participants with TRD were included in this open-label study (ClinicalTrials.gov identifier: NCT06085950) and underwent an intensive 5-day course of mTUS with a total of 25 sessions of 5 min each.</div></div><div><h3>Results</h3><div>No serious adverse events occurred during the study. By day 5 of treatment, depression severity was reduced by an average of 60.9 % (range: [30 %–83.9 %]), and four out of five patients qualified as responders, with two of them in remission.</div></div><div><h3>Conclusions</h3><div>This study provides first-in-human evidence of the potential of mTUS as a precise, safe and effective non-invasive neuromodulation technique for neuropsychiatric disorders involving deep brain regions, offering a safer and more accessible alternative to invasive approaches.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 1004-1014"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prior-information Robbins–Monro sequence for rapid motor thresholding of transcranial magnetic stimulation","authors":"Siwei Liu,&nbsp;Boshuo Wang,&nbsp;Ke Ma,&nbsp;Xuyi Hu,&nbsp;Lari M. Koponen,&nbsp;Angel V. Peterchev,&nbsp;S.M. Mahdi Alavi,&nbsp;Stephan M. Goetz","doi":"10.1016/j.brs.2025.03.017","DOIUrl":"10.1016/j.brs.2025.03.017","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 1015-1018"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations","authors":"Isaac Grennan ,&nbsp;Brook Perry ,&nbsp;Anna Verghese ,&nbsp;Melissa Jones ,&nbsp;Oliver Härmson ,&nbsp;Colin G. McNamara ,&nbsp;Andrew Sharott","doi":"10.1016/j.brs.2025.04.019","DOIUrl":"10.1016/j.brs.2025.04.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Alzheimer's disease (AD) has very limited treatment options and therapies to prevent or reverse neurodegeneration remain elusive. Deep brain stimulation (DBS), whereby high-frequency pulses of electricity are delivered continuously to a specific part of the brain, has been trialled as an experimental treatment for AD. In AD patients, continuous, high frequency DBS targeted to the fornix (fx-DBS) has been shown to be safe, but not reliably effective across patients. In movement disorders, high-frequency DBS is thought to act as a virtual lesion, disrupting pathophysiological activity. In AD, it may be more advantageous to use stimulation to reinforce or rebuild oscillatory activities that are disrupted by the disease process. A primary candidate for such a target is the hippocampal theta oscillation, which provides a temporal framework for mnemonic processing and is altered in rodent models of AD.</div></div><div><h3>Material and methods</h3><div>We applied closed-loop electrical stimulation to the fornix of rats traversing a linear track, triggered by different phases of the ongoing theta oscillation in the hippocampal local field potential (LFP) using the OscillTrack algorithm.</div></div><div><h3>Results</h3><div>Stimulation at different target phases could robustly suppress or amplify the theta oscillation, and these effects were significantly larger than those caused by open-loop replay of the same stimulation pattern. Amplification of the theta oscillation could be achieved irrespective of the locomotor speed of the animal, showing that it did not result from a secondary effect of behavioural change.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that closed-loop fx-DBS is a viable method of modulating the amplitude of hippocampal theta oscillations that could be applied in human devices to provide a constructive intervention with the potential to boost memory circuit function in AD.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 993-1003"},"PeriodicalIF":7.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}