Brain Stimulation最新文献

{"title":"Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals","authors":"Jasmina Paneva ,&nbsp;Teresa Schuhmann ,&nbsp;Stefanie De Smet ,&nbsp;Terence De Meza ,&nbsp;Felix Duecker ,&nbsp;Alexander T. Sack","doi":"10.1016/j.brs.2025.04.002","DOIUrl":"10.1016/j.brs.2025.04.002","url":null,"abstract":"<div><h3>Introduction</h3><div>High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) targeting the left dorsolateral prefrontal cortex (lDLPFC) is an established, clinically effective treatment for major depressive disorder (MDD). However, evidence of the cognitive effects of lDLPFC HF-rTMS, especially those cognitive functions affected by MDD, is mixed.</div></div><div><h3>Methods</h3><div>We here assessed the cognitive effects of a single, offline, 10Hz rTMS session on task performance in an emotional faces N-back (EFNBACK) task, in both healthy and depressed individuals. We measured response times, accuracy, and sensitivity, in a sham-controlled, pre-post design. Importantly, using the Beck Depression Inventory (BDI-II), we assessed whether the cognitive effects of the stimulation are state-dependent on trait-state depression.</div></div><div><h3>Results</h3><div>We found lDLPFC HF-rTMS enhanced cognitive control over angry distractors. More importantly, these cognitive control effects were state-dependent on trait-state depression. HF-rTMS produced distinct performance changes dependent on baseline BDI-II scores. As a function of BDI-II scores, we observed either increased or decreased response times on the task. Further, we observed improved accuracy and sensitivity only on angry distractor trials as BDI-II scores increased, as a consequence of lDLPFC stimulation.</div></div><div><h3>Conclusion</h3><div>These results underscore the role of HF-rTMS in enhancing executive control over negative emotional information by modulating lDLPFC, with effects varying according to depression state at the moment of the treatment session. HF-rTMS thus not only enhances inhibitory control over emotional stimuli but also exhibits such cognitive effects contingent on depressive state, contributing to our understanding of the state-dependence of therapeutic rTMS.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 745-752"},"PeriodicalIF":7.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to ‘Safety considerations for transcranial ultrasound stimulation: A comment on Nandi et al.’","authors":"Tulika Nandi ,&nbsp;Benjamin R. Kop ,&nbsp;Kim Butts Pauly ,&nbsp;Charlotte J. Stagg ,&nbsp;Lennart Verhagen","doi":"10.1016/j.brs.2025.03.023","DOIUrl":"10.1016/j.brs.2025.03.023","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Page 755"},"PeriodicalIF":7.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability of clinical benefit with Stanford Neuromodulation Therapy (SNT) in treatment-resistant depression","authors":"Andrew D. Geoly,&nbsp;Katy H. Stimpson,&nbsp;Flint M. Espil,&nbsp;Brandon S. Bentzley,&nbsp;Nolan R. Williams","doi":"10.1016/j.brs.2025.04.006","DOIUrl":"10.1016/j.brs.2025.04.006","url":null,"abstract":"<div><h3>Background</h3><div>Depression, the leading cause of disability worldwide, is a chronic disease characterized by a relapsing-remitting course. Acute treatments such as electroconvulsive therapy, ketamine, and repetitive transcranial magnetic stimulation are often effective at initiating remission, but relapse to a major depressive episode is common without ongoing interventions. Stanford Neuromodulation Therapy (SNT) produces high rates of remission after five days of acute treatment; however, the duration of this remission following a single course of SNT in people suffering from treatment-resistant depression is unknown, which poses a significant limit on clinical decision-making.</div></div><div><h3>Methods</h3><div>Forty-six participants with treatment-resistant depression (TRD), received five days of SNT. Functional connectivity derived from resting-state functional MRI (fMRI) was used to individually target the region of the left dorsolateral prefrontal cortex most functionally anticorrelated with the subgenual anterior cingulate cortex. The 6-item Hamilton Depression Rating Scale (HDRS-6) was collected fortnightly for up to 24 weeks. Relapse was defined as two consecutive HDRS-6 scores of 5 or above.</div></div><div><h3>Results</h3><div>Seventy percent (32 of 46) of participants entered remission the week following treatment. After 12 weeks of treatment, 15 of 46 (33 %) participants remained in remission. Of the participants who entered remission, 15 of 32 (47 %) remained in remission.</div></div><div><h3>Conclusions</h3><div>At 12 weeks, a subset of participants remained in remission, suggesting that the durability of SNT warrants further study. Comparisons with conventional rTMS should be interpreted cautiously given differences in study design, populations, and outcome measures.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 875-881"},"PeriodicalIF":7.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on “Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease”","authors":"Amirreza Dastan ,&nbsp;Paulina Skrzypkowska ,&nbsp;Tomasz Szmuda ,&nbsp;Piotr Zieliński","doi":"10.1016/j.brs.2025.04.004","DOIUrl":"10.1016/j.brs.2025.04.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 736-737"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized models of Beam/F3 targeting in transcranial magnetic stimulation for depression: Implications for precision clinical translation","authors":"Divya Rajasekharan ,&nbsp;Michelle R. Madore ,&nbsp;Paul Holtzheimer ,&nbsp;Kelvin O. Lim ,&nbsp;Leanne M. Williams ,&nbsp;Noah S. Philip","doi":"10.1016/j.brs.2025.04.003","DOIUrl":"10.1016/j.brs.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>Clinical transcranial magnetic stimulation (TMS) for depression routinely relies on the scalp-based Beam/F3 targeting method to identify stimulation targets in the dorsolateral prefrontal cortex (dLPFC). Scalp-based targeting offers a low-cost and easily implemented method for TMS coil placement, enhancing treatment availability. However, limited anatomical and functional specificity of the Beam/F3 method may affect treatment outcomes, motivating assessment of the clinical standard.</div></div><div><h3>Methods</h3><div>In a naturalistic clinical trial of TMS conduced at four Veterans Affairs hospitals, the authors evaluate the Beam/F3 method using neuroimaging incorporated before TMS, after five treatment sessions, and after all thirty sessions. Personalized anatomical and electric field (E-field) models were developed to assess target location and network engagement, as well as subsequent effects on clinical outcomes.</div></div><div><h3>Results</h3><div>Anatomical models demonstrate that the Beam/F3 method produced reliable targets in the dLPFC across individuals and repeated treatment sessions. E-field models revealed that baseline anticorrelation between the stimulation center and the sgACC was associated with antidepressant symptom response after five TMS sessions (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.032</mn><mo>,</mo><msup><mi>r</mi><mn>2</mn></msup><mo>=</mo><mn>0.100</mn><mo>,</mo><mi>N</mi><mo>=</mo><mn>46</mn></mrow></math></span>) and at the end of treatment (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.042</mn><mo>,</mo><msup><mi>r</mi><mn>2</mn></msup><mo>=</mo><mn>0.107</mn><mo>,</mo><mi>N</mi><mo>=</mo><mn>39</mn></mrow></math></span>). Relatedly, E-field magnitude at the sgACC-anticorrelated peak in the prefrontal cortex correlated with symptom response throughout treatment (early treatment: <span><math><mrow><mi>p</mi><mo>=</mo><mn>0.001</mn><mo>,</mo><msup><mi>r</mi><mn>2</mn></msup><mo>=</mo><mn>0.220</mn><mo>,</mo><mi>N</mi><mo>=</mo><mn>46</mn></mrow></math></span>; end of treatment: <span><math><mrow><mi>p</mi><mo>=</mo><mn>0.026</mn><mo>,</mo><msup><mi>r</mi><mn>2</mn></msup><mo>=</mo><mn>0.127</mn><mo>,</mo><mi>N</mi><mo>=</mo><mn>39</mn></mrow></math></span>).</div></div><div><h3>Conclusions</h3><div>This work establishes that scalp-based targeting can produce reliable targets in the dLPFC and be successfully evaluated using a combination of neuroimaging and E-field modeling in pragmatic, multisite applications. Importantly, this investigation also found that significant network effects occur early in treatment and that Beam/F3 targets can engage functional mechanisms in TMS.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 829-837"},"PeriodicalIF":7.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aperiodic activity as a biomarker of seizures and neuromodulation","authors":"David Satzer ,&nbsp;Lesley C. Kaye ,&nbsp;Steven G. Ojemann ,&nbsp;Daniel R. Kramer ,&nbsp;John A. Thompson","doi":"10.1016/j.brs.2025.03.022","DOIUrl":"10.1016/j.brs.2025.03.022","url":null,"abstract":"<div><h3>Introduction</h3><div>Mounting evidence suggests the efficacy of neuromodulation for epilepsy is mediated by network remodeling and neural state. Epilepsy network related pathophysiology has been associated with variation in the aperiodic exponent, which describes the inverse relationship between frequency and power and has been linked to synaptic-level processes. This study sought to assess relationships between periodic and aperiodic activity, disease state, and responsive stimulation.</div></div><div><h3>Methods</h3><div>Chronic intracranial EEG was recorded from 13 patients undergoing responsive neurostimulation for epilepsy. Recordings containing clinician-annotated seizures, stimulation triggered by device-detected interictal epileptiform activity (IEA), and stimulation-free interictal periods were analyzed. Multidien IEA cycles were identified, and recordings were classified by cycle phase. Power spectra were parameterized into periodic and aperiodic components using an established algorithm.</div></div><div><h3>Results</h3><div>The aperiodic exponent was larger during seizures and pre-stimulation intervals than stimulation-free interictal recordings, and decreased following stimulation. A rise in aperiodic exponent was observed in the 12 h preceding seizures. Larger aperiodic exponent was observed during the rising phase of multidien IEA cycles. Periodic alpha and beta power were larger during seizures, pre-stimulation intervals, and high-risk (rising and/or peak) IEA cycle phases, whereas periodic theta and gamma power exhibited variable relationships. Periodic power did not change after stimulation or in the hours before seizures for any studied frequency band.</div></div><div><h3>Conclusions</h3><div>The aperiodic exponent was positively related to instantaneous and multidien disease state severity and negatively related to therapeutic stimulation. Aperiodic activity may emerge as a practical biomarker of disease state and treatment response to guide neuromodulation for epilepsy.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 738-744"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation and methylphenidate interact to increase cognitive persistence as a core component of metacontrol: Evidence from aperiodic activity analyses","authors":"Yang Gao ,&nbsp;Anna Helin Koyun ,&nbsp;Veit Roessner ,&nbsp;Ann-Kathrin Stock ,&nbsp;Moritz Mückschel ,&nbsp;Lorenza Colzato ,&nbsp;Bernhard Hommel ,&nbsp;Christian Beste","doi":"10.1016/j.brs.2025.03.024","DOIUrl":"10.1016/j.brs.2025.03.024","url":null,"abstract":"<div><h3>Background</h3><div>Metacontrol is the ability to optimize the balance between cognitive persistence and flexibility. Recent research points to aperiodic EEG activity as a neurophysiological marker for metacontrol and its modulations. However, the causal link between metacontrol and aperiodic activity is still unclear.</div></div><div><h3>Objective</h3><div>We provide mechanistic insights into the neurobiological foundations of metacontrol and the means to enhance it. We evaluated the interplay of anodal transcranial direct current stimulation (atDCS) and Methylphenidate (MPH), both of which are known to alter cortical noise, a factor that can be measured by aperiodic exponents derived from EEG data.</div></div><div><h3>Methods</h3><div>We examined the impact of right inferior frontal (midpoint between electrodes FC4 and F8) 20 min offline atDCS at 2-mA and MPH administration, both separately and combined, on aperiodic EEG activity while healthy adult participants (N = 98) performed a Go/NoGo task. We used the FOOOF (fitting oscillations &amp; one over f) algorithm to examine aperiodic activity.</div></div><div><h3>Results</h3><div>We obtained an interaction between atDCS stimulation and MPH administration, indicating that atDCS is effective in reducing aperiodic neural activity (i.e., increased aperiodic exponents) when being combined with MPH administration.</div></div><div><h3>Conclusion</h3><div>Aperiodic neural activity can be modulated through pharmacology-tuned atDCS. atDCS and MPH rely on overlapping neurobiological mechanisms. Metacontrol depending on aperiodic neural activity can be modulated through combined atDCS-MPH stimulation. Hence, atDCS and MPH are suitable tools to achieve an exogenous modulation of metacontrol bias and aperiodic exponents are indices to demonstrate the effectiveness of such tools.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 720-729"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating brain network dynamics in state-dependent stimulation: A concurrent electroencephalography and transcranial magnetic stimulation study using hidden Markov models","authors":"Saeed Makkinayeri ,&nbsp;Roberto Guidotti ,&nbsp;Alessio Basti ,&nbsp;Mark W. Woolrich ,&nbsp;Chetan Gohil ,&nbsp;Mauro Pettorruso ,&nbsp;Maria Ermolova ,&nbsp;Risto J. Ilmoniemi ,&nbsp;Ulf Ziemann ,&nbsp;Gian Luca Romani ,&nbsp;Vittorio Pizzella ,&nbsp;Laura Marzetti","doi":"10.1016/j.brs.2025.03.020","DOIUrl":"10.1016/j.brs.2025.03.020","url":null,"abstract":"<div><h3>Background</h3><div>Systems neuroscience studies have shown that baseline brain activity can be categorized into large-scale networks (resting-state-networks, RNSs), with influence on cognitive abilities and clinical symptoms. These insights have guided millimeter-precise selection of brain stimulation targets based on RSNs. Concurrently, Transcranial Magnetic Stimulation (TMS) studies revealed that baseline brain states, measured by EEG signal power or phase, affect stimulation outcomes. However, EEG dynamics in these studies are mostly limited to single regions or channels, lacking the spatial resolution needed for accurate network-level characterization.</div></div><div><h3>Objective</h3><div>We aim at mapping brain networks with high spatial and temporal precision and to assess whether the occurrence of specific network-level-states impact TMS outcome. To this end, we will identify large-scale brain networks and explore how their dynamics relates to corticospinal excitability.</div></div><div><h3>Methods</h3><div>This study leverages Hidden Markov Models to identify large-scale brain states from pre-stimulus source space high-density-EEG data collected during TMS targeting the left primary motor cortex in twenty healthy subjects. The association between states and fMRI-defined RSNs was explored using the Yeo atlas, and the trial-by-trial relation between states and corticospinal excitability was examined.</div></div><div><h3>Results</h3><div>We extracted fast-dynamic large-scale brain states with unique spatiotemporal and spectral features resembling major RSNs. The engagement of different networks significantly influences corticospinal excitability, with larger motor evoked potentials when baseline activity was dominated by the sensorimotor network.</div></div><div><h3>Conclusions</h3><div>These findings represent a step forward towards characterizing brain network in EEG-TMS with both high spatial and temporal resolution and underscore the importance of incorporating large-scale network dynamics into TMS experiments.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 800-809"},"PeriodicalIF":7.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced zero-phase synchronization as a potential neural code for optimized visuomotor integration","authors":"Kirstin-Friederike Heise ,&nbsp;Geneviève Albouy ,&nbsp;Nina Dolfen ,&nbsp;Ronald Peeters ,&nbsp;Dante Mantini ,&nbsp;Stephan P. Swinnen","doi":"10.1016/j.brs.2025.03.019","DOIUrl":"10.1016/j.brs.2025.03.019","url":null,"abstract":"<div><h3>Background</h3><div>Goal-directed behavior requires the integration of information from the outside world and internal (somatosensory) sources about our own actions. Expectations (or ‘internal models’) are generated from prior knowledge and constantly updated based on sensory feedback. This optimized information integration (‘predictive coding') results in a global behavioral advantage of anticipated action in the presence of uncertainty. Our goal was to probe the effect of phase entrainment of the sensorimotor mu-rhythm on visuomotor integration.</div></div><div><h3>Methods</h3><div>Participants received transcranial alternating current stimulation over bilateral motor cortices (M1) while performing a visually-guided force adjustment task during functional magnetic resonance imaging.</div></div><div><h3>Results</h3><div>Inter-hemispheric zero-phase entrainment resulted in effector-specific modulation of performance precision and effector-generic minimization of force signal complexity paralleled by BOLD activation changes in bilateral caudate and increased functional connectivity between the right M1 and contralateral putamen, inferior parietal, and medial temporal regions. While effector-specific changes in performance precision were associated with contralateral caudate and hippocampal activation decreases, only the global reduction in force signal complexity was associated with increased functional M1 connectivity with bilateral striatal regions.</div></div><div><h3>Conclusion</h3><div>We propose that zero-phase synchronization represents a neural mode of optimized information integration related to internal model updating within the recursive perception-action continuum associated with predictive coding.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":"Pages 756-767"},"PeriodicalIF":7.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Effects of Spaced Transcranial Direct Current Stimulation in Major Depression","authors":"Véronique Desbeaumes Jodoin ,&nbsp;Emma Bousseau ,&nbsp;Maxime Couture ,&nbsp;Paul Lespérance ,&nbsp;Jean-Philippe Miron","doi":"10.1016/j.brs.2025.03.016","DOIUrl":"10.1016/j.brs.2025.03.016","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 3","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}