Brain Stimulation最新文献

{"title":"Response regarding: Frontal HD-tACS enhances behavioral and EEG biomarkers of vigilance in continuous attention task","authors":"Nigel Gebodh, Marom Bikson","doi":"10.1016/j.brs.2024.11.004","DOIUrl":"10.1016/j.brs.2024.11.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1277-1278"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of accelerated high-dose and low-dose magnetic stimulation for freezing of gait in Parkinson's disease","authors":"Jinmei Sun, Xin Chen, Jinying Han, Mengqi Wang, Ziye Zhao, Lili Hu, Zhenxiong Yuliu, Gong-Jun Ji , Kai Wang , Panpan Hu","doi":"10.1016/j.brs.2024.10.011","DOIUrl":"10.1016/j.brs.2024.10.011","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1247-1249"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evoked resonant neural activity in the pallidal-subthalamic circuit during dual lead deep brain stimulation in DYT-TOR1A dystonia: A case study","authors":"Kara A. Johnson, Filipe P. Sarmento, Joshua K. Wong, Justin D. Hilliard, Kelly D. Foote, Coralie de Hemptinne","doi":"10.1016/j.brs.2024.11.001","DOIUrl":"10.1016/j.brs.2024.11.001","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1253-1255"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and pilot efficacy of self-applied home-based cognitive training and brain stimulation: A randomized-controlled trial","authors":"Merle Rocke, Anna E. Fromm, Nora Jansen, Friederike Thams, Catalina Trujillo-Llano, Ulrike Grittner, Daria Antonenko , Agnes Flöel","doi":"10.1016/j.brs.2024.10.009","DOIUrl":"10.1016/j.brs.2024.10.009","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1241-1243"},"PeriodicalIF":7.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between parameters and effects in transcranial ultrasonic stimulation","authors":"Tulika Nandi ,&nbsp;Benjamin R. Kop ,&nbsp;Kim Butts Pauly ,&nbsp;Charlotte J. Stagg ,&nbsp;Lennart Verhagen","doi":"10.1016/j.brs.2024.10.008","DOIUrl":"10.1016/j.brs.2024.10.008","url":null,"abstract":"<div><div>Transcranial ultrasonic stimulation (TUS) is rapidly gaining traction for non-invasive human neuromodulation, with a pressing need to establish protocols that maximise neuromodulatory efficacy. In this review, we aggregate and examine empirical evidence for the relationship between tunable TUS parameters and <em>in vitro</em> and <em>in vivo</em> outcomes. Based on this multiscale approach, TUS researchers can make better informed decisions about optimal parameter settings. Importantly, we also discuss the challenges involved in extrapolating results from prior empirical work to future interventions, including the translation of protocols between models and the complex interaction between TUS protocols and the brain. A synthesis of the empirical evidence suggests that larger effects will be observed at lower frequencies within the sub-MHz range, higher intensities and pressures than commonly administered thus far, and longer pulses and pulse train durations. Nevertheless, we emphasise the need for cautious interpretation of empirical data from different experimental paradigms when basing protocols on prior work as we advance towards refined TUS parameters for human neuromodulation.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1216-1228"},"PeriodicalIF":7.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards objective, temporally resolved neurobehavioral predictors of emotional state","authors":"Katherine E. Kabotyanski,&nbsp;Han G. Yi,&nbsp;Rahul Hingorani,&nbsp;Brian S. Robinson,&nbsp;Hannah P. Cowley,&nbsp;Matthew S. Fifer,&nbsp;Brock A. Wester,&nbsp;Bishal Lamichhane,&nbsp;Ashutosh Sabharwal,&nbsp;Anusha B. Allawala,&nbsp;Sameer V. Rajesh,&nbsp;Nabeel Diab,&nbsp;Raissa K. Mathura,&nbsp;Victoria Pirtle,&nbsp;Joshua Adkinson,&nbsp;Andrew J. Watrous,&nbsp;Eleonora Bartoli,&nbsp;Jiayang Xiao,&nbsp;Garrett P. Banks,&nbsp;Sanjay J. Mathew,&nbsp;Sameer A. Sheth","doi":"10.1016/j.brs.2024.10.007","DOIUrl":"10.1016/j.brs.2024.10.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":""},"PeriodicalIF":7.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracortical microstimulation of human somatosensory cortex induces natural perceptual biases","authors":"Charles M. Greenspon ,&nbsp;Natalya D. Shelchkova ,&nbsp;Taylor G. Hobbs ,&nbsp;Sliman J. Bensmaia ,&nbsp;Robert A. Gaunt","doi":"10.1016/j.brs.2024.10.005","DOIUrl":"10.1016/j.brs.2024.10.005","url":null,"abstract":"<div><div>Time-order error, a psychophysical phenomenon in which the duration in between successive stimuli alters perception, has been studied for decades by neuroscientists and psychologists. To date, however, the locus of these effects is unknown. We use intracortical microstimulation of somatosensory cortex in three humans with spinal cord injury as a tool to bypass initial stages of processing and restrict the possible locations that signals could be modified. Using a 2-interval forced choice amplitude discrimination paradigm, we first assessed the extent to which order effects are observed. Comparing trials where the standard stimulus was in the first or second interval, we found that systematic biases are exhibited, typically causing the intensity of the second stimulus to be overestimated The degree of this overestimation for individual electrodes was dependent on the perceptual sensitivity to changes in stimulus amplitude. To investigate the role of memory on this phenomenon, we implemented a 2-interval magnitude estimation task in which participants were instructed to ignore the first stimulus and again found that the perceptual intensity of the second stimulus tended to be enhanced by the first in a manner that depended on the amplitude and duration of the first stimulus. Finally, we repeated both paradigms while varying the inter-stimulus interval to examine the timescale over which these effects occur and found that longer inter-stimulus intervals reduced the effect size. These results show that direct activation of primary somatosensory cortex is sufficient to induce time-order errors.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1178-1185"},"PeriodicalIF":7.6,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury","authors":"Thallita K. Rabelo ,&nbsp;Ana Carolina P. Campos ,&nbsp;Thiago H. Almeida Souza ,&nbsp;Faiza Mahmud ,&nbsp;Milos R. Popovic ,&nbsp;Luciene Covolan ,&nbsp;Victor H.C. Betta ,&nbsp;Leodante DaCosta ,&nbsp;Nir Lipsman ,&nbsp;Mustansir Diwan ,&nbsp;Clement Hamani","doi":"10.1016/j.brs.2024.10.006","DOIUrl":"10.1016/j.brs.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Traumatic brain injury (TBI) is a major life-threatening event. In addition to neurological deficits, it can lead to long-term impairments in attention and memory. Deep brain stimulation (DBS) is an established therapy for movement disorders that has been recently investigated for memory improvement in various disorders. In models of TBI, stimulation delivered to different brain targets has been administered to rodents long after the injury with the objective of treating motor deficits, coordination and memory impairment.</div></div><div><h3>Objective</h3><div>To test the hypothesis that DBS administered soon after TBI may prevent the development of memory deficits and exert neuroprotective effects.</div></div><div><h3>Methods</h3><div>Male rats were implanted with DBS electrodes in the anterior nucleus of the thalamus (ANT) one week prior to lateral fluid percussion injury (FPI). Immediately after TBI, animals received active or sham stimulation for 6 h. Four days later, they were assessed in a novel object/novel location recognition test (NOR/NLR) and a Barnes maze paradigm. After the experiments, hippocampal cells were counted. Separate groups of animals were sacrificed at different timepoints after TBI to measure cytokines and brain derived neurotrophic factor (BDNF). In a second set of experiments, TBI-exposed animals receiving active or sham stimulation were injected with the tropomyosin receptor kinase B (TrkB) antagonist ANA-12, followed by behavioural testing.</div></div><div><h3>Results</h3><div>Rats exposed to TBI given DBS had an improvement in several variables of the Barnes maze, but no significant improvements in NOR/NLR compared to Sham DBS TBI animals or non-implanted controls. Animals receiving stimulation had a significant increase in BDNF levels, as well as in hippocampal cell counts in the hilus, CA3 and CA1 regions. DBS failed to normalize the increased levels of TNFα and the proinflammatory cytokine IL1β in the perilesional cortex and the hippocampus of the TBI-exposed animals. Pharmacological experiments revealed that ANA-12 administered alongside DBS did not counter the memory improvement observed in ANT stimulated animals.</div></div><div><h3>Conclusions</h3><div>DBS delivered immediately after TBI mitigated memory deficits, increased the expression of BDNF and the number of hippocampal cells in rats. Mechanisms for these effects were not related to an anti-inflammatory effect or mediated via TrkB receptors.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1186-1196"},"PeriodicalIF":7.6,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain metabolic response to repetitive transcranial magnetic stimulation to lesion network in cervical dystonia","authors":"Aleksi Kokkonen ,&nbsp;Daniel T. Corp ,&nbsp;Juho Aaltonen ,&nbsp;Jussi Hirvonen ,&nbsp;Anna K. Kirjavainen ,&nbsp;Johan Rajander ,&nbsp;Juho Joutsa","doi":"10.1016/j.brs.2024.10.004","DOIUrl":"10.1016/j.brs.2024.10.004","url":null,"abstract":"<div><h3>Background</h3><div>A previous study identified a brain network underlying cervical dystonia (CD) based on causal brain lesions. This network was shown to be abnormal in idiopathic CD and aligned with connections mediating treatment response to deep brain stimulation, suggesting generalizability across etiologies and relevance for treatment. The main nodes of this network were located in the deep cerebellar structures and somatosensory cortex (S1), the latter of which can be easily reached via non-invasive brain stimulation. To date, there are no studies testing brain stimulation to networks identified using lesion network mapping.</div></div><div><h3>Objectives</h3><div>To assess target engagement by stimulating the S1 and testing the brain's acute metabolic response to repetitive transcranial magnetic stimulation in CD patients and healthy controls.</div></div><div><h3>Methods</h3><div>Thirteen CD patients and 14 controls received a single session of continuous theta burst (cTBS) and sham to the right S1. Changes in regional brain glucose metabolism were measured using [¹⁸F]FDG-PET.</div></div><div><h3>Results</h3><div>cTBS increased metabolism at the stimulation site in CD (P = 0.03) but not in controls (P = 0.15; group difference P = 0.01). In subcortical regions, cTBS increased metabolism in the brainstem in CD only (P_FDR = 0.04). The remote activation was positively associated with dystonia severity and efficacy of sensory trick phenomenon in CD patients.</div></div><div><h3>Conclusions</h3><div>Our results provide further evidence of abnormal sensory system function in CD and show that a single session of S1 cTBS is sufficient to induce measurable changes in brain glucose metabolism. These findings support target engagement, motivating therapeutic trials of cTBS to the S1 in CD.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1171-1177"},"PeriodicalIF":7.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced auditory perception and brain response with quiet TMS coil","authors":"David L.K. Murphy ,&nbsp;Lari M. Koponen ,&nbsp;Eleanor Wood ,&nbsp;Yiru Li ,&nbsp;Noreen Bukhari-Parlakturk ,&nbsp;Stefan M. Goetz ,&nbsp;Angel V. Peterchev","doi":"10.1016/j.brs.2024.10.003","DOIUrl":"10.1016/j.brs.2024.10.003","url":null,"abstract":"<div><h3>Background</h3><div>Electromagnetic forces in transcranial magnetic stimulation (TMS) coils generate a loud clicking sound that produces confounding auditory activation and is potentially hazardous to hearing. To reduce this noise while maintaining stimulation efficiency similar to conventional TMS coils, we previously developed a quiet TMS double containment coil (qTMS-DCC).</div></div><div><h3>Objective</h3><div>To compare the stimulation strength, perceived loudness, and EEG response between qTMS-DCC and a commercial TMS coil.</div></div><div><h3>Methods</h3><div>Nine healthy volunteers participated in a within-subject study design. The resting motor thresholds (RMTs) for qTMS-DCC and MagVenture Cool-B65 were measured. Psychoacoustic titration matched the Cool-B65 loudness to qTMS-DCC pulsed at 80, 100, and 120 % RMT. Event-related potentials (ERPs) were recorded for both coils. The psychoacoustic titration and ERPs were acquired with the coils both on and 6 cm off the scalp, the latter isolating the effects of airborne auditory stimulation from body sound and electromagnetic stimulation. The ERP comparisons focused on a centro-frontal region that encompassed peak responses in the global signal while stimulating the primary motor cortex.</div></div><div><h3>Results</h3><div>RMT did not differ significantly between the coils, with or without the EEG cap on the head. qTMS-DCC was perceived to be substantially quieter than Cool-B65. For example, qTMS-DCC at 100 % coil-specific RMT sounded like Cool-B65 at 34 % RMT. The general ERP waveform and topography were similar between the two coils, as were early-latency components, indicating comparable electromagnetic brain stimulation in the on-scalp condition. qTMS- DCC had a significantly smaller P180 component in both on-scalp and off-scalp conditions, supporting reduced auditory activation.</div></div><div><h3>Conclusions</h3><div>The stimulation efficiency of qTMS-DCC matched Cool-B65 while having substantially lower perceived loudness and auditory-evoked potentials.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 6","pages":"Pages 1197-1207"},"PeriodicalIF":7.6,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}