Brain Stimulation最新文献

{"title":"Strategies to mitigate scalp discomfort during repetitive transcranial magnetic stimulation","authors":"Jennifer I. Lissemore, Derrick M. Buchanan, Jean-Marie Batail, Irakli Kaloiani, Clive Veerapal, Gregory L. Sahlem, Nolan R. Williams","doi":"10.1016/j.brs.2024.09.004","DOIUrl":"10.1016/j.brs.2024.09.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1131-1133"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X2400158X/pdfft?md5=ce09f7224f4628bd4d8ecca8ce4b012c&pid=1-s2.0-S1935861X2400158X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How conductivity boundaries influence the electric field induced by transcranial magnetic stimulation in in vitro experiments","authors":"Padmavathi Sundaram ,&nbsp;Chunling Dong ,&nbsp;Sergey Makaroff ,&nbsp;Yoshio Okada","doi":"10.1016/j.brs.2024.08.003","DOIUrl":"10.1016/j.brs.2024.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Although transcranial magnetic stimulation (TMS) has become a valuable method for non-invasive brain stimulation, the cellular basis of TMS activation of neurons is still not fully understood. <em>In vitro</em> preparations have been used to understand the biophysical mechanisms of TMS, but in many cases these studies have encountered substantial difficulties in activating neurons.</p></div><div><h3>Objective/hypothesis</h3><p>The hypothesis of this work is that conductivity boundaries can have large effects on the electric field in commonly used <em>in vitro</em> preparations. Our goal was to analyze the resulting difficulties in <em>in vitro</em> TMS using a simulation study, using a charge-based boundary element model.</p></div><div><h3>Methods</h3><p>We decomposed the total electric field into the sum of the primary electric field, which only depends on coil geometry and current, and the secondary electric field arising from conductivity boundaries, which strongly depends on tissue and chamber geometry. We investigated the effect of the conductivity boundaries on the electric field strength for a variety of <em>in vitro</em> experimental settings to determine the sources of difficulty.</p></div><div><h3>Results</h3><p>We showed that conductivity boundaries can have large effects on the electric field in in vitro preparations. Depending on the geometry of the air-saline and the saline-tissue interfaces, the secondary electric field can significantly enhance, or attenuate the primary electric field, resulting in a much stronger or weaker total electric field inside the tissue; we showed this using a realistic preparation. Submerged chambers are generally much more efficient than interface chambers since the secondary field due to the thin film of saline covering the tissue in the interface chamber opposes the primary field and significantly reduces the total field in the tissue placed in the interface chamber. The relative dimensions of the chamber and the TMS coil critically determine the total field; the popular setup with a large coil and a small chamber is particularly sub-optimal because the secondary field due to the air-chamber boundary opposes the primary field, thereby attenuating the total field. The form factor (length vs width) of the tissue in the direction of the induced field can be important since a relatively narrow tissue enhances the total field at the saline-tissue boundary.</p></div><div><h3>Conclusions</h3><p>Overall, we found that the total electric field in the tissue is higher in submerged chambers, higher if the chamber size is larger than the coil and if the shorter tissue dimension is in the direction of the electric field. Decomposing the total field into the primary and secondary fields is useful for designing <em>in vitro</em> experiments and interpreting the results.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1034-1044"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001402/pdfft?md5=d2bf92663a048e0444cdf459d4ff06cc&pid=1-s2.0-S1935861X24001402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organotypic culture of post-mortem adult human brain explants exhibits synaptic plasticity","authors":"Yukiko Iwasaki ,&nbsp;Corentin Bernou ,&nbsp;Barbara Gorda ,&nbsp;Sophie Colomb ,&nbsp;Gowrishankar Ganesh ,&nbsp;Raphael Gaudin","doi":"10.1016/j.brs.2024.08.010","DOIUrl":"10.1016/j.brs.2024.08.010","url":null,"abstract":"<div><h3>Background</h3><p>Synaptic plasticity is an essential process encoding fine-tuned brain functions, but models to study this process in adult human systems are lacking.</p></div><div><h3>Objective</h3><p>We aim to test whether <em>ex vivo</em> organotypic culture of <em>post-mortem</em> adult brain explants (OPABs) retain synaptic plasticity.</p></div><div><h3>Methods</h3><p>OPABs were seeded on 3D microelectrode arrays to measure local field potential (LFP). Paired stimulation of distant electrodes was performed over three days to investigate our capacity to modulate specific neuronal connections.</p></div><div><h3>Results</h3><p>Long-term potentiation (LTP) or depression (LTD) did not occur within a single day. In contrast, after two and three days of training, OPABs showed a significant modulation of the paired electrodes’ response compared to the non-paired electrodes from the same array. This response was alleviated upon treatment with dopamine.</p></div><div><h3>Conclusion</h3><p>Our work highlights that adult human brain explants retain synaptic plasticity, offering novel approaches to neural circuitry in animal-free models.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 1018-1023"},"PeriodicalIF":7.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001517/pdfft?md5=78b4072b693d4ee334322844bbe9ae18&pid=1-s2.0-S1935861X24001517-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic labeling of the nucleus of tractus solitarius neurons associated with electrical stimulation of the cervical or auricular vagus nerve in mice","authors":"Md Sams Sazzad Ali ,&nbsp;Ghazaal Parastooei ,&nbsp;Swarnalakshmi Raman ,&nbsp;Jalen Mack ,&nbsp;Yu Shin Kim ,&nbsp;Man-Kyo Chung","doi":"10.1016/j.brs.2024.08.007","DOIUrl":"10.1016/j.brs.2024.08.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Vagus nerve stimulation (VNS) is clinically useful for treating epilepsy, depression, and chronic pain. Currently, cervical VNS (cVNS) treatment is well-established, while auricular VNS (aVNS) is under development. Vagal stimulation regulates functions in diverse brain regions; therefore, it is critical to better understand how electrically-evoked vagal inputs following cVNS and aVNS engage with different brain regions.</p></div><div><h3>Objective</h3><p>As vagus inputs are predominantly transmitted to the nucleus of tractus solitarius (NTS), we directly compared the activation of NTS neurons by cVNS or aVNS and the brain regions directly projected by the activated NTS neurons in mice.</p></div><div><h3>Methods</h3><p>We adopted the targeted recombination in active populations method, which allows for the activity-dependent, tamoxifen-inducible expression of mCherry—a reporter protein—in neurons specifically associated with cVNS or aVNS.</p></div><div><h3>Results</h3><p>cVNS and aVNS induced comparable bilateral mCherry expressions in neurons within the NTS, especially in its caudal section (cNTS). However, the numbers of mCherry-expressing neurons within different subdivisions of cNTS was distinctive. In both cVNS and aVNS, anterogradely labeled mCherry-expressing axonal terminals were similarly observed across different areas of the forebrain, midbrain, and hindbrain. These terminals were enriched in the rostral ventromedial medulla, parabrachial nucleus, periaqueductal gray, thalamic nuclei, central amygdala, and the hypothalamus. Sex difference of cVNS- and aVNS-induced labeling of NTS neurons was modest.</p></div><div><h3>Conclusion</h3><p>The central projections of mCherry-expressing cNTS terminals are comparable between aVNS and cVNS, suggesting that cVNS and aVNS activate distinct but largely overlapping projections into the brain through the cNTS.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 987-1000"},"PeriodicalIF":7.6,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001487/pdfft?md5=d254ac45e846a22c61872ecb8827d3f9&pid=1-s2.0-S1935861X24001487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic reorganization of the somatomotor network in multiple sclerosis - Evidence from edge-centric functional connectivity analysis","authors":"Gabriel Gonzalez-Escamilla,&nbsp;Vinzenz Fleischer,&nbsp;Neus Mongay-Ochoa,&nbsp;Maren Person,&nbsp;Marie Martschenko,&nbsp;Dumitru Ciolac,&nbsp;Angela Radetz,&nbsp;Yaroslav Winter,&nbsp;Julia Schiffer,&nbsp;Felix Luessi,&nbsp;Marianne Hahn,&nbsp;Stefan Bittner,&nbsp;Frauke Zipp,&nbsp;Sven Meuth,&nbsp;Sergiu Groppa","doi":"10.1016/j.brs.2024.08.005","DOIUrl":"10.1016/j.brs.2024.08.005","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 980-982"},"PeriodicalIF":7.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001463/pdfft?md5=71c520aafbd30bfc2fe65f0144636379&pid=1-s2.0-S1935861X24001463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mise en abyme of post-traumatic stress disorder and infantile regression revealed by intracranial electrical stimulation in epilepsy","authors":"Alexis Robin,&nbsp;Emmanuel J. Barbeau,&nbsp;Marie Denuelle,&nbsp;Abel Guillen,&nbsp;Amaury De Barros,&nbsp;Jean Christophe Sol,&nbsp;Helene Mirabel,&nbsp;Jean Albert Lotterie,&nbsp;Antoine Yrondi,&nbsp;Florence Rulquin,&nbsp;Luc Valton,&nbsp;Jonathan Curot","doi":"10.1016/j.brs.2024.08.004","DOIUrl":"10.1016/j.brs.2024.08.004","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 983-986"},"PeriodicalIF":7.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001451/pdfft?md5=f8fbacae5d3325abb0e6e47a5c358842&pid=1-s2.0-S1935861X24001451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrographic seizures during low-current thalamic deep brain stimulation in mice","authors":"Francisco J. Flores ,&nbsp;Isabella Dalla Betta ,&nbsp;John Tauber ,&nbsp;David R. Schreier ,&nbsp;Emily P. Stephen ,&nbsp;Matthew A. Wilson ,&nbsp;Emery N. Brown","doi":"10.1016/j.brs.2024.08.002","DOIUrl":"10.1016/j.brs.2024.08.002","url":null,"abstract":"<div><h3>Background:</h3><p>Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).</p></div><div><h3>Objectives:</h3><p>To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.</p></div><div><h3>Methods:</h3><p>Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.</p></div><div><h3>Results:</h3><p>In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 <span><math><mi>μ</mi></math></span>A.</p></div><div><h3>Conclusion:</h3><p>Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 5","pages":"Pages 975-979"},"PeriodicalIF":7.6,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001396/pdfft?md5=4a5031ea12fd19ee626e0f7c60987f5a&pid=1-s2.0-S1935861X24001396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain","authors":"Alexander In ,&nbsp;Andrew Strohman ,&nbsp;Brighton Payne ,&nbsp;Wynn Legon","doi":"10.1016/j.brs.2024.07.020","DOIUrl":"10.1016/j.brs.2024.07.020","url":null,"abstract":"<div><h3>Background</h3><p>The insula and dorsal anterior cingulate cortex (dACC) are core brain regions involved in pain processing and central sensitization, a shared mechanism across various chronic pain conditions. Methods to modulate these regions may serve to reduce central sensitization, though it is unclear which target may be most efficacious for different measures of central sensitization.</p><p>Objective/Hypothesis: Investigate the effect of low-intensity focused ultrasound (LIFU) to the anterior insula (AI), posterior insula (PI), or dACC on conditioned pain modulation (CPM) and temporal summation of pain (TSP).</p></div><div><h3>Methods</h3><p>N = 16 volunteers underwent TSP and CPM pain tasks pre/post a 10 min LIFU intervention to either the AI, PI, dACC or Sham stimulation. Pain ratings were collected pre/post LIFU.</p></div><div><h3>Results</h3><p>Only LIFU to the PI significantly attenuated pain ratings during the TSP protocol. No effects were found for the CPM task for any of the LIFU targets. LIFU pressure modulated group means but did not affect overall group differences.</p></div><div><h3>Conclusions</h3><p>LIFU to the PI reduced temporal summation of pain. This may, in part, be due to dosing (pressure) of LIFU. Inhibition of the PI with LIFU may be a future potential therapy in chronic pain populations demonstrating central sensitization. The minimal effective dose of LIFU for efficacious neuromodulation will help to translate LIFU for therapeutic options.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 911-924"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001359/pdfft?md5=b89bd51689517283aee816a8dcdff808&pid=1-s2.0-S1935861X24001359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Model-based navigation of transcranial focused ultrasound neuromodulation in humans: Application to targeting the amygdala and thalamus","authors":"Mohammad Daneshzand ,&nbsp;Bastien Guerin ,&nbsp;Parker Kotlarz ,&nbsp;Tina Chou ,&nbsp;Darin D. Dougherty ,&nbsp;Brian L. Edlow ,&nbsp;Aapo Nummenmaa","doi":"10.1016/j.brs.2024.07.019","DOIUrl":"10.1016/j.brs.2024.07.019","url":null,"abstract":"<div><h3>Background</h3><p>Transcranial focused ultrasound (tFUS) neuromodulation has shown promise in animals but is challenging to translate to humans because of the thicker skull that heavily scatters ultrasound waves.</p></div><div><h3>Objective</h3><p>We develop and disseminate a model-based navigation (MBN) tool for acoustic dose delivery in the presence of skull aberrations that is easy to use by non-specialists.</p></div><div><h3>Methods</h3><p>We pre-compute acoustic beams for thousands of virtual transducer locations on the scalp of the subject under study. We use the hybrid angular spectrum solver mSOUND, which runs in ∼4 s per solve per CPU yielding pre-computation times under 1 h for scalp meshes with up to 4000 faces and a parallelization factor of 5. We combine this pre-computed set of beam solutions with optical tracking, thus allowing real-time display of the tFUS beam as the operator freely navigates the transducer around the subject’ scalp. We assess the impact of MBN versus line-of-sight targeting (LOST) positioning in simulations of 13 subjects.</p></div><div><h3>Results</h3><p>Our navigation tool has a display refresh rate of ∼10 Hz. In our simulations, MBN increased the acoustic dose in the thalamus and amygdala by 8–67 % compared to LOST and avoided complete target misses that affected 10–20 % of LOST cases. MBN also yielded a lower variability of the deposited dose across subjects than LOST.</p></div><div><h3>Conclusions</h3><p>MBN may yield greater and more consistent (less variable) ultrasound dose deposition than transducer placement with line-of-sight targeting, and thus could become a helpful tool to improve the efficacy of tFUS neuromodulation.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 958-969"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X24001347/pdfft?md5=ad9fd2206dcd2a63f944adbc60c6c58d&pid=1-s2.0-S1935861X24001347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the local field potential signal from the subthalamic nucleus for phase-targeted auditory stimulation in Parkinson's disease","authors":"Elena Krugliakova ,&nbsp;Artyom Karpovich ,&nbsp;Lennart Stieglitz ,&nbsp;Stephanie Huwiler ,&nbsp;Caroline Lustenberger ,&nbsp;Lukas Imbach ,&nbsp;Bartosz Bujan ,&nbsp;Piotr Jedrysiak ,&nbsp;Maria Jacomet ,&nbsp;Christian R. Baumann ,&nbsp;Sara Fattinger","doi":"10.1016/j.brs.2024.06.007","DOIUrl":"10.1016/j.brs.2024.06.007","url":null,"abstract":"<div><h3>Background</h3><p>Enhancing slow waves, the electrophysiological (EEG) manifestation of non-rapid eye movement (NREM) sleep, could potentially benefit patients with Parkinson's disease (PD) by improving sleep quality and slowing disease progression. Phase-targeted auditory stimulation (PTAS) is an approach to enhance slow waves, which are detected in real-time in the surface EEG signal.</p></div><div><h3>Objective</h3><p>We aimed to test whether the local-field potential of the subthalamic nucleus (STN-LFP) can be used to detect frontal slow waves and assess the electrophysiological changes related to PTAS.</p></div><div><h3>Methods</h3><p>We recruited patients diagnosed with PD and undergoing Percept™ PC neurostimulator (Medtronic) implantation for deep brain stimulation of STN (STN-DBS) in a two-step surgery. Patients underwent three full-night recordings, including one between-surgeries recording and two during rehabilitation, one with DBS+ (on) and one with DBS- (off). Surface EEG and STN-LFP signals from Percept PC were recorded simultaneously, and PTAS was applied during sleep in all three recording sessions.</p></div><div><h3>Results</h3><p>Our results show that during NREM sleep, slow waves of the cortex and STN are time-locked. PTAS application resulted in power and coherence changes, which can be detected in STN-LFP.</p></div><div><h3>Conclusion</h3><p>Our findings suggest the feasibility of implementing PTAS using solely STN-LFP signal for slow wave detection, thus without a need for an external EEG device alongside the implanted neurostimulator. Moreover, we propose options for more efficient STN-LFP signal preprocessing, including different referencing and filtering to enhance the reliability of cortical slow wave detection in STN-LFP recordings.</p></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"17 4","pages":"Pages 769-779"},"PeriodicalIF":7.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1935861X2400113X/pdfft?md5=c10762022136b21c2c7948bb844b468d&pid=1-s2.0-S1935861X2400113X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}