Brain Stimulation最新文献

{"title":"Spinal cord stimulation restores locomotion in a Parkinson's disease patient and rodents.","authors":"Jacob C Slack, Benjamin Rees, Eleonora Borda, Jonah Slack, Miguel A L Nicolelis, S Elizabeth Zauber, Kunal Gupta, Amol P Yadav","doi":"10.1016/j.brs.2025.07.020","DOIUrl":"10.1016/j.brs.2025.07.020","url":null,"abstract":"<p><strong>Introduction: </strong>Dorsal column stimulation (DCS) of the spinal cord is emerging as a promising new technology to treat Parkinson's disease (PD). However, optimal stimulation settings that maximize its therapeutic effect on PD symptoms are yet to be determined. To optimize DCS therapy, it is necessary to understand its impact on pathological brain oscillations and to deliver stimulation triggered by neurophysiological biomarkers of PD.</p><p><strong>Materials and methods: </strong>We developed beta-triggered DCS (BT-DCS), where DCS was triggered by ongoing corticostriatal beta oscillations, and tested it in the bilateral intra-striatal 6-hydroxydopamine (6-OHDA) rat model of PD. To evaluate the translational potential of DCS in humans, we recorded local field potentials (LFPs) from bilateral subthalamic nucleus (STN) electrodes in a sixty-year-old PD subject with freezing of gait (FOG) symptoms before and three days after implantation of DCS leads.</p><p><strong>Results: </strong>DCS triggered by corticostriatal beta oscillations facilitated a pro-locomotion brain state that improved locomotion, reduced akinesia, and desynchronized ongoing oscillations in the rat model. BT-DCS achieved higher efficacy with less overall charge delivery than continuous stimulation. In the PD subject, DCS increased gait velocity and stride length, reduced freezing episodes, and desynchronized subthalamic nucleus (STN) beta oscillations, while modulating phase-amplitude coupling (PAC). When applied simultaneously with deep brain stimulation (DBS), DCS had a combinatory effect on gait improvement.</p><p><strong>Conclusion: </strong>Based on the effective implementation of BT-DCS in modulating supraspinal pathological brain activity in rats, we envision that incorporating a brain biomarker signal in delivering DCS therapy in humans could improve relief from Parkinsonian gait issues.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1407-1422"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing control conditions for entraining neural oscillations using rhythmic TMS.","authors":"Runhao Lu, Isabelle Woods Rogan, Alexandra Woolgar","doi":"10.1016/j.brs.2025.07.002","DOIUrl":"10.1016/j.brs.2025.07.002","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1367-1369"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring GABA-A dysfunction in chronic functional vomiting: An intrinsic case study of TMS-EMG guided precision treatment with etifoxine.","authors":"Sayan Saha, Harsh Pathak, Swarnabuddha Nayok, Vinayaka Hegde, Priyavarshini Boopathy, Vyoma Shah, Pragathi Balasubramani, Vanteemar S Sreeraj, Shivarama Varambally, Ganesan Venkatasubramanian","doi":"10.1016/j.brs.2025.07.015","DOIUrl":"10.1016/j.brs.2025.07.015","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1389-1391"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive magnetic stimulation with iTBS600 induces persistent structural and functional plasticity in mouse organotypic slice cultures.","authors":"Han Lu, Shreyash Garg, Maximilian Lenz, Andreas Vlachos","doi":"10.1016/j.brs.2025.07.008","DOIUrl":"10.1016/j.brs.2025.07.008","url":null,"abstract":"<p><strong>Background: </strong>Repetitive transcranial magnetic stimulation (rTMS) is well known for its ability to induce synaptic plasticity, yet its impact on structural and functional remodeling within stimulated networks remains unclear. This study investigates the cellular and network-level mechanisms of rTMS-induced plasticity using a clinically approved 600-pulse intermittent theta burst stimulation (iTBS600) protocol applied to mouse organotypic brain tissue cultures.</p><p><strong>Methods: </strong>We applied iTBS600 to entorhino-hippocampal organotypic tissue cultures and conducted a 24-hour analysis using c-Fos immunostaining, whole-cell patch-clamp recordings, time-lapse imaging of dendritic spines, and calcium imaging.</p><p><strong>Results: </strong>We observed long-term potentiation (LTP) of excitatory synapses in dentate granule cells, characterized by increased mEPSC frequencies and spine remodeling over time. c-Fos expression in the dentate gyrus was transient and exhibited a clear sensitivity to the orientation of the induced electric field, suggesting a direction-dependent induction of plasticity. Structural remodeling of dendritic spines was temporally linked to enhanced synaptic strength, while spontaneous calcium activity remained stable during the early phase in the dentate gyrus, indicating the engagement of homeostatic mechanisms. Despite the widespread electric field generated by rTMS, its effects were spatially and temporally precise, driving Hebbian plasticity and region-specific spine dynamics.</p><p><strong>Conclusions: </strong>These findings provide mechanistic insights into how rTMS-induced LTP promotes targeted plasticity while preserving network stability. Understanding these interactions may help refine stimulation protocols to optimize therapeutic outcomes.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1392-1402"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial ultrasonic stimulation of cerebellar fastigial nucleus: First-in-Human feasibility study","authors":"Mersedeh Bahr-Hosseini ,&nbsp;Norman M. Spivak ,&nbsp;Amber R. Hopkins ,&nbsp;Stefannia Cisneros ,&nbsp;Christopher Hanuscin ,&nbsp;Angshuman Saha ,&nbsp;Jared Gilbert ,&nbsp;Samantha Schafer ,&nbsp;Mark E. Schafer ,&nbsp;David S. Liebeskind ,&nbsp;Martin M. Monti ,&nbsp;Jeffrey L. Saver","doi":"10.1016/j.brs.2025.08.020","DOIUrl":"10.1016/j.brs.2025.08.020","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1663-1666"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Targeted neural stimulation congruent with immersive reality decreases neuropathic pain","authors":"Giuseppe Valerio Aurucci ,&nbsp;Noemi Gozzi ,&nbsp;Markus Wagner ,&nbsp;Greta Preatoni ,&nbsp;Nicola Brunello ,&nbsp;Andrea Cimolato ,&nbsp;Natalija Secerovic ,&nbsp;Carl Moritz Zipser ,&nbsp;Stanisa Raspopovic","doi":"10.1016/j.brs.2025.08.023","DOIUrl":"10.1016/j.brs.2025.08.023","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1671-1674"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model.","authors":"Kristen M Scheitler, Juan M Rojas-Cabrera, Sara A Vettleson-Trutza, Sheng-Ta Tsai, Guillermo K Pons-Monnier, Mohamed M El-Gohary, Ron Scheer, Youngjong Kwak, Damiano G Barone, Charles D Blaha, Tyler S Oesterle, Hojin Shin, Kendall H Lee, Yoonbae Oh","doi":"10.1016/j.brs.2025.07.007","DOIUrl":"10.1016/j.brs.2025.07.007","url":null,"abstract":"","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1441-1443"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial magnetic vs intracranial electric stimulation: a direct comparison of their effects via scalp EEG recordings.","authors":"Renzo Comolatti, Gabriel Hassan, Ezequiel Mikulan, Simone Russo, Michele A Colombo, Elisabetta Litterio, Giulia Furregoni, Sasha D'Ambrosio, Matteo Fecchio, Sara Parmigiani, Ivana Sartori, Silvia Casarotto, Andrea Pigorini, Marcello Massimini","doi":"10.1016/j.brs.2025.07.016","DOIUrl":"10.1016/j.brs.2025.07.016","url":null,"abstract":"<p><strong>Background: </strong>Single-pulse Transcranial Magnetic Stimulation (TMS) and Intracranial Electrical Stimulation (IES) are widely used to probe cortical excitability and connectivity, but their electrophysiological effects have never been compared.</p><p><strong>Objective: </strong>This study aims to fill this gap by using high-density scalp electroencephalogram (hd-EEG) as a common read-out to compare human brain responses to TMS and IES.</p><p><strong>Methods: </strong>The dataset includes TMS-evoked potentials (TEPs) acquired from healthy subjects (n = 22) and IES-evoked potentials (IEPs) recorded from drug-resistant epileptic patients (n = 31) during wakefulness. In a subset of subjects TEPs (n = 12) and IEPs (n = 13) were also recorded during NREM sleep. Amplitude, spectral, and spatiotemporal features of TMS and IES responses, as well as their estimated electrical fields, were compared.</p><p><strong>Results: </strong>We observed marked differences between TMS and IES responses. During wakefulness, IEPs are considerably larger, slower and associated with a suppression of cortical activity, whereas TEPs are characterized by multiple waves of recurrent activation. These differences are attenuated in NREM, during which both TMS and IES elicit large EEG responses associated with a prominent suppression of cortical activity. At the global level, the spatiotemporal complexity of the responses to both TMS and IES decreases consistently following the transition from wakefulness to NREM sleep.</p><p><strong>Conclusion: </strong>Despite the limitations due to different subject populations (healthy vs pathological), our findings provide a first reference to parallel non-invasive and invasive brain stimulation and to interpret their differential effects. They also offer important insight on how cortical responsiveness is shaped by inhibition and adaptation mechanisms depending on input parameters and brain states.</p>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":" ","pages":"1444-1454"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of atorvastatin-loaded PEGylated liposomes delivered by magnetic stimulation for stroke treatment","authors":"Ji-Hye Kim ,&nbsp;Ja-Hae Kim ,&nbsp;Hafiz Ashfaq Ahmad ,&nbsp;Hohyeon Kim ,&nbsp;Raveena Nagareddy ,&nbsp;Kang-Ho Choi ,&nbsp;Jungwon Yoon ,&nbsp;Yong-Yeon Jeong","doi":"10.1016/j.brs.2025.08.024","DOIUrl":"10.1016/j.brs.2025.08.024","url":null,"abstract":"<div><h3>Background</h3><div>Focused magnetic stimulation (MagStim) can temporarily and safely open the blood-brain barrier (BBB) for target delivery. We investigated whether opening the BBB with MagStim and delivering atorvastatin-loaded PEGylated liposomes (LipoStatin) would work synergistically for subacute post-stroke treatment.</div></div><div><h3>Methods</h3><div>Two weeks after middle cerebral artery occlusion (MCAO), an injection of 15 mg/ml magnetic nanoparticles (MNPs) was performed, followed by 30 min of MagStim, in subacute stroke models. The procedure was conducted over a week, during which MagStim and MNPs were administered three times at two-day intervals, and LipoStatin (10 mg/kg) was injected immediately after each MagStim treatment. We investigated the motor function, BBB integrity, neuroinflammation, and neurogenesis three weeks after stroke (Sham vs. Control vs. LipoStatin vs. MagStim + LipoStatin).</div></div><div><h3>Results</h3><div>The MagStim + LipoStatin group showed improved motor function compared to the Control (<em>p</em> = 0.007) group. The MagStim + LipoStatin group significantly reduced infarct volume and improved BBB integrity compared to the control and LipoStatin groups. In the MagStim + LipoStatin group, the expression of TNF-α was reduced (<em>p</em> = 0.020) compared to the LipoStatin group, and eNOS was enhanced (<em>p =</em> 0.037) compared to the Control group. Markers for neurogenesis were also considerably increased in the MagStim + LipoStatin group compared to the Control and LipoStatin groups (<em>p &lt;</em> 0.0001).</div></div><div><h3>Conclusions</h3><div>Our study demonstrates the beneficial synergistic effects of MagStim and the target delivery of LipoStatin in subacute ischemic stroke. These findings underscore the need for future advancements in promising novel non-invasive MagStim methods and nanotherapeutic hybrid approaches for target drug delivery and treatment in post-stroke recovery.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1620-1631"},"PeriodicalIF":8.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting subcallosal cingulate deep brain stimulation for depression: Long-term safety and effectiveness outcomes from a pooled analysis of 172 implanted patients","authors":"Lyndahl M. Himes ,&nbsp;Helen S. Mayberg ,&nbsp;Mustafa M. Husain ,&nbsp;Paul E. Holtzheimer ,&nbsp;Andres M. Lozano ,&nbsp;Sidney H. Kennedy ,&nbsp;Robert E. Gross ,&nbsp;Brian H. Kopell ,&nbsp;Martijn Figee ,&nbsp;Konstantin V. Slavin ,&nbsp;Julie G. Pilitsis ,&nbsp;Joseph S. Neimat ,&nbsp;Clement Hamani ,&nbsp;Nader Pouratian ,&nbsp;Peter Giacobbe ,&nbsp;Alon Y. Mogilner ,&nbsp;Devyani Nanduri ,&nbsp;Binith J. Cheeran ,&nbsp;Yagna J. Pathak ,&nbsp;Patricio Riva-Posse","doi":"10.1016/j.brs.2025.08.017","DOIUrl":"10.1016/j.brs.2025.08.017","url":null,"abstract":"<div><h3>Objective</h3><div>Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) has been investigated clinically for treatment-resistant depression (TRD). Although the initial BROADEN study, a randomized controlled trial, was halted after an interim futility analysis, observation of long-term follow-up (LTFU) data from this and other cohorts demonstrated sustained improvement in depressive symptoms, prompting further investigation of DBS as a therapeutic option.</div></div><div><h3>Methods</h3><div>Data from 5 studies, including BROADEN, were used to evaluate the long-term safety and effectiveness of SCC DBS for TRD. Effectiveness measures included percent change in HDRS-17 and MADRS, response and partial response rate, and remission rate. Outcomes were assessed through five years post-implant, with primary analyses focused on the first 24 months due to attrition after this point. Sensitivity analyses were performed to evaluate robustness of the results, and adverse events were summarized.</div></div><div><h3>Results</h3><div>172 subjects were implanted in 5 studies across 5 countries. Average age was 47.9 years, 8.1 years in the current depressive episode, and 88 % had received electroconvulsive therapy (ECT). Effectiveness outcomes were analyzed through 24 months; additional data through five years are available in the supplement. Average MADRS reduction was 43 % at 12 months and 53 % at 24 months post-device activation, with response rates of 46 % and 55 %, and partial response rates of 13.3 % and 15.5 %, respectively. Observed case and sensitivity analyses for both MADRS and HDRS-17 showed a significant reduction in depressive symptoms at each follow-up visit. Safety data from four studies included 151 implanted subjects with 523 patient-years. Incidence of suicide was 0.55 per 100 patient-years.</div></div><div><h3>Conclusions</h3><div>Active SCC DBS shows continuous and sustained improvement in depressive symptomatology from the first year onward. While several limitations may impact the validity of these findings, SCC DBS has the possibility to provide a safe and durable treatment for TRD.</div></div>","PeriodicalId":9206,"journal":{"name":"Brain Stimulation","volume":"18 5","pages":"Pages 1632-1640"},"PeriodicalIF":8.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}