BMC Women's Health最新文献

{"title":"A rare case of malignant transformation: squamous cell carcinoma arising on the basis of an ovarian mature cystic teratoma.","authors":"Furkan Özdem, Sümeyya Duran Kaymak, Berna Turhan, Candost Hanedan, Sezgi Barlas, Özge Demirsoy, Rasime Pelin Kavak","doi":"10.1186/s12905-025-03755-7","DOIUrl":"https://doi.org/10.1186/s12905-025-03755-7","url":null,"abstract":"<p><strong>Background: </strong>Ovarian mature cystic teratomas (MCTs) are the most prevalent benign ovarian tumors, with rare potential for malignant transformation, most commonly into squamous cell carcinoma. Accurate diagnosis is crucial for optimal management and prognosis.</p><p><strong>Case presentation: </strong>A 27-year-old woman presented with a year-long history of intermittent abdominal and groin pain. Imaging studies, including contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI), revealed a mixed solid-cystic lesion in the left adnexal region, consistent with an MCT exhibiting radiologic signs of malignancy. The patient underwent unilateral salpingo-oophorectomy, and intraoperative frozen section analysis suggested a mature cystic teratoma. However, definitive histopathological examination confirmed squamous cell carcinoma arising from the MCT. This case highlights the limitations of frozen section analysis in detecting malignancy.</p><p><strong>Conclusion: </strong>Malignant transformation of MCTs, though rare, poses significant diagnostic and therapeutic challenges. Comprehensive preoperative imaging and meticulous postoperative histopathological evaluation are essential for accurate diagnosis and effective management. This case underscores the importance of interdisciplinary collaboration in addressing complex gynecologic pathologies.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"213"},"PeriodicalIF":2.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of social determinants of health on feminicide in the second-largest state of the Brazilian Amazon: a spatial epidemiological analysis.","authors":"Ana Karoline Souza da Silva, Iaron Leal Seabra, Euriane Castro Costa, Mary Elizabeth de Santana, Vera Lúcia de Azevedo Lima, Glenda Roberta Oliveira Naiff Ferreira, Eliã Pinheiro Botelho","doi":"10.1186/s12905-025-03747-7","DOIUrl":"https://doi.org/10.1186/s12905-025-03747-7","url":null,"abstract":"<p><strong>Introduction: </strong>Despite global advancements in gender equality and legal frameworks, feminicide remains a persistent issue worldwide. Spatial analysis is a powerful tool to use in obtaining evidence-based recommendations for more effective policies to fight it. In Brazil the state of Pará was highlighted with the sixth highest increase in the feminicide rate between 2019 and 2022. In this study, we spatially analyzed feminicide rates in Pará, from 2016 to 2021, employing spatial distribution and autocorrelation, spatio-temporal, and geographically weighted regression (GWR) techniques.</p><p><strong>Methods: </strong>Annual number of feminicide incidents from all municipalities in Pará were provided by Secretariat of Intelligence and Criminal Analysis of Pará. Municipalities crude feminicide rates were calculated and analyzed using spatial distribution and spatial autocorrelation (Getis-Ord G analysis) to identify areas with a high burden of feminicide. Spatio-temporal risk analysis was employed to assess the influences of policies and social factors on feminicide trends over space and time. GWR was used to evaluate the influence of social determinants of health in the spatial variability of feminicide rates.</p><p><strong>Results: </strong>During the study period, feminicide rates expanded spatially in Pará, with municipalities in Belem metropolitan area and in the northeast, southeast and southwest mesoregions of Pará being the most affected. Between 2016 and 2018, there was a hotspot cluster (neighbor municipalities sharing high feminicide rates) located in southwest and southeast of Pará. From 2019 to 2021, this hotspot contracted, and a new one appeared in the northeast. The spatio-temporal risk zone comprised municipalities situated in the northeast, southeast, and southwest mesoregions of Pará from 2018 to 2021. The spatial variability of feminicide was promoted by the \"high school pass rate,\" the \"youth homicide rate,\" and \"primary healthcare services coverage.\"</p><p><strong>Conclusion: </strong>Our findings highlight the need for policy interventions, including increased investment in women's shelters, expanded access to legal and psychological support for victims of gender-based violence, and the integration of gender equality education into school.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"212"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Women's Empowerment in Fertility Preferences and Outcomes: Analysis of the 2017 Indonesia Demographic and Health Survey.","authors":"Sitta Fiakhsani Taqwim, Masoud Vaezghasemi, Sara Castel-Feced, Fatwa Sari Tetra Dewi, Julia Schröders","doi":"10.1186/s12905-025-03748-6","DOIUrl":"https://doi.org/10.1186/s12905-025-03748-6","url":null,"abstract":"<p><strong>Background: </strong>With a population of 275 million, Indonesia is the world's fourth most populous country and has made considerable efforts to reduce its Total Fertility Rate from 5.6 in 1971 to a target of 2.1 by 2024. Women's empowerment has been identified as a critical factor influencing fertility dynamics, gender equality, reproductive autonomy, and broader socioeconomic development. This study examines the association between four dimensions of women's empowerment and three fertility-related outcomes among married women aged 22 years and older in Indonesia.</p><p><strong>Methods: </strong>We used cross-sectional data from 34,017 married women participating in the 2017 Indonesia Demographic and Health Survey (IDHS). An outcome-wide analytical approach was adopted to explore three outcomes: total number of children ever born, ideal number of children, and fertility preference alignment, i.e. whether actual fertility matched stated preferences. Four empowerment domains were assessed: household decision-making, attitudes toward wife beating, attitudes toward refusing sex, and labour force participation. Stepwise multivariate Poisson regression modelling was applied, adjusting for key demographic and socioeconomic covariates.</p><p><strong>Results: </strong>Our study found that the association between each type of women's empowerment and fertility-related outcomes varied, reinforcing the notion that empowerment does not uniformly affect reproductive behaviour. Among the four empowerment indicators, rejecting all justifications for wife beating emerged as the most consistent and significant predictor across all fertility outcomes. It was association with fewer children ever born (β = 0.03), a lower ideal number of children (β = 0.04), and a higher likelihood of meeting fertility preferences (PR = 1.02). Attitudes toward refusing sex were also significantly associated with fewer children (β = 0.02) and lower fertility ideals (β = 0.07). However, participation in decision-making and labour force participation showed mixed or non-significant associations, indicating that different empowerment dimensions may influence reproductive behaviour in diverse ways.</p><p><strong>Conclusions: </strong>Women's empowerment - particularly in the domains of gender-based violence and sexual autonomy - is closely linked to fertility preferences and behaviours. The findings underscore that empowerment is a multidimensional construct, with varying influences across its domains. Strengthening women's autonomy and addressing gender-based violence are essential steps toward enhancing reproductive rights and achieving Sustainable Development Goal 5 in Indonesia. Gender-sensitive data systems and interventions tailored to different aspects of empowerment are urgently needed.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"211"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasminogen activator inhibitor 1 is a novel predictor in human serum/follicular fluid for diminished ovarian reserve.","authors":"Xinshu Li, Xue Chen, Hua Guo","doi":"10.1186/s12905-025-03710-6","DOIUrl":"https://doi.org/10.1186/s12905-025-03710-6","url":null,"abstract":"<p><strong>Background: </strong>Diminished ovarian reserve (DOR) is a common female reproductive aging disease, which showed significant impacts on the quality of life and fertility in women. Plasminogen activator inhibitor 1 (PAI-1) is considered to be a major profibrotic factor. The development of DOR is closely related to ovarian fibrosis. The aim of the study was to investigate the expression of PAI-1,which is clinically relevant to DOR.</p><p><strong>Methods: </strong>This case-control study included 40 infertile women with DOR and 40 infertile women with normal ovarian function. PAI-1 and reproductive hormones in serum and follicle fluid were determined in all subjects. Receiver operating characteristic curve (ROC) was applied to evaluate PAI-1 in prediction and diagnosis of DOR. The mRNA and protein expression of PAI-1 in KGN cells induced by cyclophosphamide (CTX) were observed by Western blot (WB) and quantitative real-time PCR (qRT-PCR).</p><p><strong>Results: </strong>The sensitivity and specificity of PAI-1 levels in serum/follicular fluid for predicting DOR were 90%/97.5% and 70%/82.5%, respectively. The AUC of PAI-1 in follicular fluid was 0.955(95% CI 0.913-0.997), which cutoff level and Youden index were 68.58 ng/mL and 0.825 for DOR. PAI-1 in serum and follicle fluid showed negative association with Anti-Müllerian hormone (AMH) and antral follicle count (AFC) (serum r= -0.391,r= -0.453;follicle fluid r= -0.486,r= -0.534;p < 0.01), however, they were positively correlated with follicle-stimulating hormone (FSH) and follicle-stimulating hormone/luteinizing hormone (FSH/LH) (serum r = 0.307,r = 0.388;follicle fluid r = 0.300,r = 0.384;p < 0.05). The ROC analysis indicated that serum PAI-1 has great prediction of DOR, with an AUC of 0.841, a sensitivity of 90%, and a specificity of 70%. Additionally, the qRT-PCR results demonstrated that the mRNA levels of PAI-1 increased in the CTX-induced cells (P < 0.05). The western blot results were consistent with qRT-PCR results.</p><p><strong>Conclusion: </strong>Our study reveals that the expression of PAI-1 is higher in serum and follicular fluid of DOR patients. And it is positively correlated with FSH, FSH/LH and negatively correlated with AMH/AFC, which is necessary to investigate the role of PAI-1 in regulating the growth and development of follicles and the pathogenesis of DOR in future.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"210"},"PeriodicalIF":2.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-operative expectations in patients with endometriosis - a qualitative interview study.","authors":"Nina Hirsing, Yvonne Nestoriuc, Olaf Buchweitz, Ann-Katrin Meyrose","doi":"10.1186/s12905-025-03686-3","DOIUrl":"https://doi.org/10.1186/s12905-025-03686-3","url":null,"abstract":"<p><strong>Background: </strong>Expectations determine treatment outcomes in several medical conditions. The significance of expectations for treatment outcomes in patients with endometriosis remains unknown. Endometriosis is a painful and debilitating disease that negatively affects quality of life. Up to 30% of surgically treated patients report persistent post-operative complaints and pain disability without sufficient medical explanation, indicating the impact of non-medical factors on treatment outcomes.</p><p><strong>Aim: </strong>The present qualitative study aimed to describe and understand pre-operative patient expectations, facilitators of and barriers to positive treatment outcomes.</p><p><strong>Method: </strong>As part of a large mixed-method cohort study, a subsample of N = 33 patients with endometriosis were interviewed before laparoscopy. Structured content analysis was performed.</p><p><strong>Results: </strong>Positive expectations included significant improvement or absence of complaints, receiving a diagnosis, and subsequently improved health-related quality of life. However, patients also reported negative expectations such as invalidation of their experience, persistence of complaints, or post-operative side effects. Patients perceived positive expectations as facilitators for positive treatment outcomes. Further facilitators included enhanced patient and treatment information, gynaecologists specialized in endometriosis, and greater awareness of endometriosis. Perceived barriers to good post-operative quality of life included post-operative pain and scarring, insufficient rest, avoidance behaviour, and stress.</p><p><strong>Conclusion: </strong>Positive and negative expectations coexisted. Positive expectations suggest that participants place much hope in laparoscopy. However, these positive expectations may exceed probable treatment outcomes for some patients. Negative expectations were also expressed and constituted a risk for nocebo effects. Further identified facilitators and barriers show that patients are very clear about what is helpful or not for their health-related quality of life after laparoscopy. Patient and treatment information may be enhanced to prevent unrealistic treatment expectations and nocebo effects.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"209"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiometabolic index and infertility among American women aged 20-45 years: a cross-sectional analysis from 2013-2020 NHANES data.","authors":"Yanyun Liu, Gefei Ying, Zhen Chen, Hongping Liang, Junhui Yu","doi":"10.1186/s12905-025-03746-8","DOIUrl":"https://doi.org/10.1186/s12905-025-03746-8","url":null,"abstract":"<p><strong>Background: </strong>While metabolic syndrome and obesity are established risk factors for infertility, previous studies have neglected age-specific analyses and nonlinear associations, particularly in women aged 20-45 years, a critical demographic for fertility and metabolic health. Therefore, this study aimed to examine the nonlinear relationship between Cardiometabolic Index(CMI) and infertility risk in US women of reproductive age (20-45 years) using nationally representative the National Health and Nutrition Examination Survey(NHANES) data (2013-2020).</p><p><strong>Methods: </strong>Cross-sectional data from the 2013-2020 NHANES were used to analyse 3,613 women aged 20-45 years with complete CMI and infertility data. Infertility is defined as the inability to conceive after at least 12 months of regular unprotected intercourse.The CMI was calculated using waist circumference(WC), height, triglyceride(TG), and high-density lipoprotein cholesterol (HDL-C). Multivariate logistic regression analysis, supplemented by smooth curve fitting and threshold effect analysis, was used to assess the association between CMI and infertility.</p><p><strong>Results: </strong>The mean age of the subjects was (32.8 ± 7.5) years and 488 (13.51%) of them reported infertility. CMI < 0.59 were highly correlated with risk of infertility(OR = 4.47, 95%CI: 2.19-9.15, P < 0.0001), whereas CMI ≥ 0.59 was not significantly associated with the risk of infertility (OR = 1.01, 95%CI: 0.81-1.24, P = 0.9621).</p><p><strong>Conclusion: </strong>Our results show a significant positive non-linear relationship between CMI and infertility risk in US women aged 20-45, with a threshold effect.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"206"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A communicative model of premenstrual syndrome with social determinants of health: a path analysis.","authors":"Fatemeh Vakili, Malihe Nasiri, Shayesteh Jahanfar, Seideh Hanieh Alamolhoda, Zeinab Hamzehgardeshi, Farank Salehi, Masoome Hooshmand Fini","doi":"10.1186/s12905-025-03745-9","DOIUrl":"https://doi.org/10.1186/s12905-025-03745-9","url":null,"abstract":"<p><strong>Introduction: </strong>Premenstrual syndrome (PMS) is characterized by the periodic emergence of physical, psychological, or behavioral symptoms that manifest following ovulation and subside with the commencement of menstruation. These symptoms may be intense enough to interfere with personal relationships, social engagements, or work performance. This study was undertaken to examine the relationship between social determinants of health (SDH) and premenstrual syndrome, taking into account the influence of social factors on health and disease, as well as the existing gap in knowledge regarding the impact of SDH on PMS, following the World Health Organization (WHO) model.</p><p><strong>Method: </strong>A cross-sectional study was carried out involving 600 women who visited health centers in Tehran in 2024. The questionnaires utilized comprised demographic and obstetric forms, Perceived Social Support, Physical Activity, Socioeconomic Status, Intimate Partner Violence, and the Premenstrual Symptoms Screening Tool. Data analysis employed SPSS-27, while the relationship model was assessed through path analysis in LISREL-8.8.</p><p><strong>Results: </strong>Path analysis revealed the direct impact of two intermediate factors on PMS: social support (B=-0.29) and physical activity (B=-0.35). Among the structural variables, socioeconomic status (B=-0.22) and age (B = 0.07) indirectly affected PMS. The model fit indices indicated a good fit (Chi-Square = 22.53, GFI = 0.99, RMSEA = 0.045, NFI = 0.95, NNFI = 0.94, CFI = 0.97, IFI = 0.97).</p><p><strong>Conclusion: </strong>According to the path analysis PMS is prevalent in Iranian women which indicates the necessity of screening for this disorder. In order to alleviate PMS, healthcare providers should pay attention to this condition's risk and protective factors.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"208"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can the CANKADO online application improve quality of life monitoring via the endometriosis health profile-30 in endometriosis patients: A randomized cohort study on acceptance, usability, and correlations with demographics and media usage.","authors":"Lucia Ehmann, Maresa Jäger, Lina Folger, Timo Schinköthe, Susanne Beyer, Lennard Schröder, Sven Mahner, Thomas Kolben","doi":"10.1186/s12905-025-03736-w","DOIUrl":"10.1186/s12905-025-03736-w","url":null,"abstract":"<p><strong>Background: </strong>The global increase in interest in endometriosis highlights the importance of further investigations concerning this so-called benign gynecological disease. Owing to their severe presentation of symptoms, patients suffer from an enormous impact on their health-related quality of life (HRQoL). While the paper-based assessment of quality of life via, e.g., the \"Endometriosis Health Profile-30 questionnaire (EHP-30)\" seems to be largely accepted and implemented, the electronic measurement of this patient-reported outcome (ePRO) is still rarely applied. This study aimed to analyze the acceptance and usability of electronic assessments of HRQoL in endometriosis patients via the online platform CANKADO.</p><p><strong>Methods: </strong>The study was conducted at the Department of Gynecology and Obstetrics of LMU Munich between January 2022 and February 2023. Sixty conservatively treated patients with endometriosis were recruited for the randomized cohort study, followed by randomization due to their planned interrogation modality (n paper-based = 23, n online-based = 17). Afterwards, a HRQoL assessment via the EHP-30 questionnaire was performed. An evaluation of the interrogation modalities was performed at 0, 6 and 12 months. The metric or categorical variables were compared via Fisher's exact test or the Mann‒Whitney U test. Correlation analysis was performed by calculating the Kendall Tau coefficient or Eta coefficient.</p><p><strong>Results: </strong>Forty patients completed evaluation forms at T0 (0 months), with n = 23 evaluating the paper-based interrogation modality and n = 17 evaluating the online version. At all the time of assessment, more than 80% of the patients showed a positive response to routinely performed ePRO measurements in the clinical context, expecting simplified communication, faster diagnosis, and therapeutic improvement. The online modality was rated more suitably (T0: 72.7% vs. 76.5%; T3: 60.0% vs. 90.0%), less complex (T0: 59.1% vs. 76.5%; T3: 80.0% vs. 70.0%), and less laborious (T0: 72.7% vs. 70.6%; T3: 80% each). Completion time over ten minutes was significantly correlated with low coping ability (r = 0.530; p = 0.029), lower clarity (r = 0.530; p = 0.029) and greater effort (r = 0.593; p = 0.012).</p><p><strong>Conclusions: </strong>The findings indicate high acceptance and usability of regularly performed ePRO assessments in patients with endometriosis via the online tool CANKADO.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"205"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of metabolic disorders among women of child-bearing age, 1990-2021: a population-based study1990-2021：.","authors":"Junyu Chen, Dihan Fu, Tianqi Ma, Minghong Chen, Xuerui Wang, Jun Yi","doi":"10.1186/s12905-025-03749-5","DOIUrl":"https://doi.org/10.1186/s12905-025-03749-5","url":null,"abstract":"<p><strong>Background: </strong>Metabolic disorders have a significant impact on the health of women of childbearing age (WCBA) but remain underemphasized. This study aims to assess the global, regional, and national burden of metabolic disorders in WCBA from 1990 to 2021.</p><p><strong>Methods: </strong>Prevalence, mortality, and disability-adjusted life years (DALYs) related to metabolic disorders in WCBA from 1990 to 2021 were obtained from the Global Burden of Disease (GBD) 2021. Annual percentage changes were calculated, and stratified analyses were conducted based on age, region, nation, and socio-demographic index levels to assess the distribution of metabolic disorders in WCBA.</p><p><strong>Results: </strong>Globally, the overall burden of metabolic disorders among WCBA has increased. In 2021, obesity (330.21 [148.37-518.36]) had the highest age-standardized DALYs rate, followed by hypertension (200.75 [154.67-245.47]), type 2 diabetes mellitus (175.11 [134.18-223.42]), hyperlipidemia (139.02 [101.32-173.61]), and non-alcoholic fatty liver disease (10.1 [7.17-13.92]). The most significant changes of the overall metabolic disorders burden in WCBA were observed in younger age groups. The burden of metabolic disorders was higher in less-developed regions.</p><p><strong>Conclusions: </strong>Given the marked increase in the burden of metabolic disorders among younger WCBA, it is recommended that healthcare management be reinforced for this demographic. Furthermore, based on the varying burdens observed across regions, targeted metabolic interventions for WCBA should be tailored to local conditions.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"207"},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional analysis of factors associated with cervical cancer screening in a large midwest primary care setting.","authors":"Jissy Cyriac, Gregory D Jenkins, Brittany A Strelow, Danielle J O' Laughlin, Joy N Stevens, Kathy L MacLaughlin, Jane W Njeru","doi":"10.1186/s12905-025-03741-z","DOIUrl":"https://doi.org/10.1186/s12905-025-03741-z","url":null,"abstract":"<p><strong>Background: </strong>Lower cervical cancer screening (CCS) rates have been reported among non-White populations, older women, rural populations, and populations with low socioeconomic status (SES). We evaluate associations between CCS status and individual, healthcare, and SES variables in a large primary care setting in southeast Minnesota.</p><p><strong>Methods: </strong>We identified participants assigned female sex at birth, aged 21-65 years, without hysterectomy, and eligible for CCS via cross-sectional analysis of the electronic health record. Subjects were categorized as having up-to-date CCS or not. Logistic regression was used to model CCS status, with odds ratios (OR) and respective confidence intervals (95% CI) calculated for single predictor models for demographic factors, co-morbidities, and healthcare utilization.</p><p><strong>Results: </strong>Approximately 78% (30,670 subjects) were current with CCS (total N = 39,433). Individuals who were Hispanic [OR (95% CI): 0.69 (0.62, 0.76)], non-White [0.53 (0.5, 0.56)], foreign-born [0.49 (0.46, 0.52)], and/or had limited English proficiency [0.44 (0.40, 0.49)] had lower odds of up-to-date CCS compared to Non-Hispanic, White, US-born, and/or English-speaking individuals. Older age, higher comorbidity burden, greater healthcare utilization, and having a female primary care provider were associated with higher odds of up-to-date CCS, while an inactive online patient portal account had lower odds of up-to-date CCS. Individuals with lower SES had lower odds of up-to-date CCS compared to those with higher SES.</p><p><strong>Conclusions: </strong>In our sample, disparities in CCS status were associated with specific individual, healthcare, and SES factors/characteristics. Our results identify populations that may benefit from targeted interventions to address CCS uptake.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"204"},"PeriodicalIF":2.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}