BMC Women's Health最新文献

{"title":"Incidence and predictors of pregnancy among reproductive-age women in an ART clinic of public health facilities in Arsi zone, southeastern ethiopia: a five-year retrospective cohort study.","authors":"Legesse Tadesse Wodajo, Jibril Bashir Adem, Tewodros Desalegn Nebi, Solomon Tejineh Mengesha, Ismael Kalayu Sitotaw, Shimelis Mekit Belachew, Martha Aseffa, Biruk Legesse Tadesse","doi":"10.1186/s12905-025-03876-z","DOIUrl":"https://doi.org/10.1186/s12905-025-03876-z","url":null,"abstract":"<p><strong>Introduction: </strong>According to global monitoring and UNAIDS estimates. In Sub-Saharan African (SSA) countries, the number of pregnant women living with HIV in 2020 was 1.2 million. A variety of studies revealed that people living with HIV desire reproduction in the absence of any ART administered to the mother; the rate of mother-to-child transmission (MTCT) of HIV is 25-45%. Transmission and most child deaths related to HIV can be avoided with appropriate care during pregnancy, childbirth, and breastfeeding. So far, there is limited information on the incidence of pregnancy outcomes and their predictors in Ethiopia. Therefore, this study aims to determine pregnancy incidence and associated factors among reproductive-age women living with HIV/AIDS who are on ART clinic follow-up in public health facilities of the Arsi Zone, central Ethiopia.</p><p><strong>Methods: </strong>An institution-based retrospective cohort study was employed among 481 reproductive-age women from December 2013 to April 2019 in ART clinics of selected public health facilities in the Arsi Zone, Ethiopia. Systematic random sampling was used to select study subjects from each public health facility. Data were imported into Epidata version 3.2 and exported into Stata version 14.2 for analysis. The Cox proportional hazards model and Kaplan-Meier failure models were used to determine pregnancy predictors and estimate incidence, respectively. Independent predictors of pregnancy were determined by looking at variables that showed significant results (P value < 0.05) in the multivariate analysis.</p><p><strong>Results: </strong>The study included 481 women in total, yielding a response rate of 96.2%. The overall incidence of pregnancy was found to be 45.47 per 1000 person-years. Being 35 years of age or older (AHR: 0.29; 95% (0.13, 0.64)), being in a non-married couple (AHR: 0.14; 95% (0.04, 0.48)), being widowed or divorced (AHR: 0.20; 95% (0.05, 0.83)), and being a single mother (AHR: 0.42; 95% (0.19, 0.92)) were predictive factors of pregnancy incidence among women on ART.</p><p><strong>Conclusion and recommendations: </strong>In this study, the incidence of pregnancy among women on ART was found to be notable. Pregnancy incidence among women on ART was found to be negatively associated with being 35 years of age or older, being in a non-married couple, being widowed or divorced, and being a single mother. To lower the risks of pregnancy, effective counseling programs must be created, with an emphasis on young and married women living with HIVAIDS.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"349"},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of letrozole combined with clomiphene in the treatment of polycystic ovary syndrome: a meta-analysis.","authors":"Baoying Du, Mengdi Ni, Ping Chen","doi":"10.1186/s12905-025-03897-8","DOIUrl":"https://doi.org/10.1186/s12905-025-03897-8","url":null,"abstract":"<p><strong>Background: </strong>PCOS is a common endocrine gynecological disorder, and its associated hormonal abnormalities and ovulatory dysfunction are leading causes of infertility. Ovulation induction is considered a fundamental treatment for PCOS patients. Clomiphene and letrozole are currently widely used ovulation-inducing agents. This study employs meta-analysis to comprehensively and systematically evaluate the clinical efficacy and adverse effects of letrozole combined with clomiphene in the treatment of PCOS.</p><p><strong>Objective: </strong>The aim of this study is to compare the clinical efficacy and adverse effects of letrozole combined with clomiphene in the treatment of PCOS, providing a theoretical basis for therapeutic decision-making.</p><p><strong>Methods: </strong>RCTs on letrozole combined with clomiphene for PCOS were retrieved from databases including PubMed, EMBASE, Cochrane Library, CNKI, Wanfang Medical Network, VIP Chinese Journal Service Platform, and CBM, with the search period spanning from database inception to March 2025. Data analysis was performed using Review Manager 5.3 and Stata software. Dichotomous variables were analyzed using RR with 95% CI, while continuous variables were assessed using SMD with 95% CI. The Cochrane Risk of Bias tool was used to evaluate the bias and risk of eligible studies. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in included studies.</p><p><strong>Results: </strong>A total of 10 studies involving 931 PCOS patients were included. Compared with the control group, letrozole combined with clomiphene significantly improved pregnancy rates (RR = 1.50, 95% CI: 1.228-1.77, P < 0.00001), ovulation rates (RR = 1.29, 95% CI: 1.15-1.444, P < 0.0001), and estradiol levels (SMD = -1.13, 95% CI: -2.02 to -0.24, P = 0.001). However, no significant effects were observed on luteinizing hormone levels (SMD = -0.48, 95% CI: -1.16 to 0.21, P = 0.17), follicle-stimulating hormone levels (SMD = -0.45, 95% CI: -1.08 to 0.17, P = 0.15), endometrial thickness (SMD = 0.69, 95% CI: -0.57 to 1.96, P = 0.28), number of mature follicles (SMD = 0.83, 95% CI: -0.26 to 1.93, P = 0.15), diameter of mature follicles (SMD = 0.77, 95% CI: -0.55 to 2.09, P = 0.25), miscarriage rates (RR = 0.38, 95% CI: 0.18 to 0.81, P < 0.0001), or adverse effects (RR = 0.77, 95% CI: 0.23 to 2.64, P = 0.68).</p><p><strong>Conclusion: </strong>Letrozole combined with clomiphene therapy helps improve ovulation rates, pregnancy rates, and hormonal levels in PCOS patients.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"344"},"PeriodicalIF":2.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Gender-Sensitive Disaster Management is Addressed in the Turkish Parliament: A Qualitative Study from Feminist Bioethics Perspective.","authors":"Fatma Gulsum Onal, Bahar Marangoz","doi":"10.1186/s12905-025-03629-y","DOIUrl":"https://doi.org/10.1186/s12905-025-03629-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The devastating earthquakes that struck Türkiye and Syria on February 6, 2023, caused significant destruction and loss of life, to the extent that they have been termed the \"Disaster of the Century.\" Although women are disproportionately affected by disasters, they have historically been overlooked in disaster management. However, with the increased awareness brought about by the feminist movement regarding secondary inequalities arising from structural disparities such as gender roles and economic dependency, the concept of \"gender-sensitive disaster management\" has gained prominence. The primary aim of our study is to evaluate how gender-sensitive disaster management is addressed in the Turkish parliament. Its secondary aim is to contribute to the scope of feminist bioethics. Thirdly, the study is expected to contribute to the ethics and policies of disaster management in Türkiye, a country prone to earthquakes, with a focus on the rights of women and vulnerable groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In the study, the transcripts of parliamentary sessions held between February 6, 2023, and April 23, 2023, as published on the official website of the Grand National Assembly of Türkiye (GNAT), were analyzed using qualitative research methods. The research data consists of discourses extracted from a total of 29 transcripts, covering the first session following the earthquake (February 7, 2023) and the final session of the legislative year (April 23, 2023). The data were systematically retrieved using the keywords \"earthquake,\" \"disaster,\" \"gender,\" \"women,\" and \"health.\" The data were coded in Excel by assigning serial numbers to the documents, and the names of the speakers were anonymized to avoid potential biases that might arise while interpreting political materials. In this study, the source data consist of publicly available documents shared on the official website, specifically the Parliamentary Record Journal prepared by the GNAT Transcripts Services Department. These documents include verbatim quotations expressed by speakers and read by clerks, all accurately written and marked in quotation marks. As the study relies on publicly accessible sources without human participants, obtaining Ethics Committee approval is not required in our country.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The recurring statements of members of parliament within the context of \"disaster and gender\" were categorized under common themes. Accordingly, the main themes identified were \"Access to Humanitarian Aid,\" \"Gender Equality and Non-Discrimination,\" and \"Vulnerability.\" Within this framework, members of parliament expressed views on topics such as the \"Right to Life,\" \"Right to Shelter,\" and \"Right to Health\" (including hygiene, sexual and reproductive health, and access to food and water). Additionally, views were expressed on sub-themes such as \"Traditional Gender Norms,\" \"Equality in Care Work,\" \"Participation,\" \"Struggle and Solidari","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"348"},"PeriodicalIF":2.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of phosphorylated Nrf2 with responses to neoadjuvant chemotherapy in patients with triple-negative breast cancer.","authors":"Jiaxuan Yu, Tianze Yao, Min Zhang, Bingxin Li, Jiping Xie, Yi Wan, Zhantian Zhang, Shiyu Yang, Yuchuan Ge, Guangze Sun, Yongqiang Yao","doi":"10.1186/s12905-025-03896-9","DOIUrl":"10.1186/s12905-025-03896-9","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant chemotherapy is the recommended treatment for stage II and III triple-negative breast cancer (TNBC). We aimed to study the role of phosphorylated Nrf2 (pNrf2) in the responses to neoadjuvant chemotherapy in TNBC patients.</p><p><strong>Methods: </strong>A prospective observational cohort study was performed in stage II and III TNBC patients who were scheduled for neoadjuvant chemotherapy between January 2017 and December 2021. The pre-treatment characteristics, including age, menses, tumor size and stages, and lymph node metastasis, were collected. The pNrf2 expression was determined by immunohistochemistry examination of tumor specimens obtained by pre-treatment core-needle biopsy. Post-treatment responses were evaluated as the clinical outcomes (RECIST) and pathological outcomes (Miller-Payne grading). Patients were assigned into either the low or high Nrf2 expression group. Their clinical characteristics and treatment responses were compared. Multivariate logistic regression analysis was performed to study the association between pNrf2 and pathological outcomes.</p><p><strong>Results: </strong>In total, 59 patients were included, with a mean age of 52.5 years old. There were 29 patients in the low pNrf2 group and 30 in the high pNrf2 group, respectively. The pre-treatment characteristics were comparable between the two groups. Compared with the low pNrf2 expression group, the high pNrf2 expression group had poorer clinical and pathological responses (P = 0.010 and < 0.001, respectively). Multivariate logistic regression analysis showed that the pNrf2 expression was negatively associated with the pathological response to neoadjuvant chemotherapy (odds ratio 0.033, 95% confidence interval 0.006-0.187).</p><p><strong>Conclusions: </strong>In patients with TNBC, the pre-treatment pNrf2 expression was negatively correlated with the response to neoadjuvant chemotherapy.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"347"},"PeriodicalIF":2.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing factors affecting age at first birth among married women in Somalia: a Bayesian shared frailty modelling approach using SDHS 2020.","authors":"Abdisalan Ahmed Osman, Abdisalam Amin Esse, Abdisalam Hassan Muse","doi":"10.1186/s12905-025-03900-2","DOIUrl":"https://doi.org/10.1186/s12905-025-03900-2","url":null,"abstract":"<p><p>This study examines factors influencing the age at first birth among married women in Somalia, focusing on sociodemographic, economic, and health-related determinants. Given Somalia's fragmented health system and high maternal mortality rates, understanding first birth timing is critical for achieving Sustainable Development Goal 3 on maternal and child health. A Bayesian shared frailty model was employed to analyze variations in birth timing, comparing Weibull, log-normal, and log-logistic models using DIC and WAIC values. The results indicate that age at first marriage is the strongest predictor, with a higher age significantly reducing the hazard of first birth (HR = 0.4636, 95% CI: 0.4399-0.4886, p < 0.001). Residence also shows a significant effect, where women in rural areas experience delayed first births (HR = 0.9411, 95% CI: 0.9026-0.9813, p < 0.01). Other factors, including region, education, wealth, contraceptive use, and marital status, were not statistically significant, while the husband's desire for children had a weak association with first-birth timing. The Bayesian log-logistic AFT shared frailty model best predicted age at first birth. Regions like Banadir were linked to earlier births, while higher education, greater wealth, and later age at first marriage were the strongest predictors of delayed childbirth. Contraceptive use, marital status, and media access had minimal impact. Socio-demographic and economic factors, especially age at marriage and education, are key determinants. Finally, the study highlights the influence of social and family dynamics on reproductive health, underscoring the need for targeted interventions to delay early childbearing and improve maternal and child health in Somalia.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"346"},"PeriodicalIF":2.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorrhagic necrosis of omental cysts misdiagnosed as torsion of ovarian cysts: a case report and literature review.","authors":"Min You, Wei Zhao, Mengyun Zhou, Ziqi Zhai, Lixia Tian, Erkai Yu","doi":"10.1186/s12905-025-03893-y","DOIUrl":"https://doi.org/10.1186/s12905-025-03893-y","url":null,"abstract":"<p><strong>Background: </strong>Omental cysts are extremely rare intra-abdominal lesions that are typically benign and asymptomatic. When hemorrhagic necrosis occurs, it may mimic other acute abdominal emergencies, such as adnexal torsion. Omental cysts are easily misdiagnosed as other diseases because of their lack of specific clinical symptoms and signs, thus posing a diagnostic challenge.</p><p><strong>Case introduction: </strong>We report a 32-year-old woman presenting with acute lower abdominal pain and fever, initially diagnosed with ovarian cyst torsion. Imaging revealed a large pelvic cystic mass; however, laparoscopic exploration identified a hemorrhagic omental cyst with necrosis and inflammatory adhesion. Complete excision was performed, and histopathology confirmed a benign omental cyst with hemorrhage and necrosis. The patient recovered uneventfully and showed no recurrence over 11 months of follow-up.</p><p><strong>Conclusion: </strong>Analyzing this case allowed us to delve into the causes of misdiagnosis of omental cysts. This case emphasizes the diagnostic difficulty posed by complicated omental cysts and highlights the necessity of considering omental cyst in women presenting with acute abdomen and pelvic masses. Imaging aids diagnosis, but surgical exploration is the most direct and reliable method for confirming the cause of abdominal pain. Timely laparoscopic intervention facilitates accurate diagnosis and effective management.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"345"},"PeriodicalIF":2.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond pelvic pathology: retinal microvascular rarefaction as a systemic marker in endometriosis.","authors":"Betül Keyif, Taha Sezer, Kübra Çolak, Zülfiye Balkan Gündogdu, Bayram Meydan","doi":"10.1186/s12905-025-03899-6","DOIUrl":"10.1186/s12905-025-03899-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to quantitatively assess retinal microvascular alterations in women with pelvic endometriosis using optical coherence tomography angiography (OCTA), and to explore whether these subclinical findings may reflect early signs of systemic microvascular alterations in this population.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, 100 eyes were analyzed-50 from women with laparoscopically or ultrasonographically confirmed pelvic endometriosis and 50 from age-matched healthy female controls. All participants underwent comprehensive ophthalmic examinations and macular OCTA imaging using the Heidelberg Spectralis system. Quantitative parameters, including vessel area density (VAD), foveal avascular zone (FAZ) metrics (area, perimeter, circularity), and FD-300 values, were extracted from the superficial and deep capillary plexuses using the OCTAVA software. Segmental parafoveal VAD values (nasal, temporal, superior, and inferior) were also assessed. Axial length measurements and endometriosis staging were not available in this retrospective dataset. Hormonal therapy use was not systematically documented.</p><p><strong>Results: </strong>Compared to healthy controls, women with endometriosis demonstrated significantly lower total and parafoveal VAD and FD-300 values in both retinal plexuses (p < 0.05 for all). FAZ perimeter showed a modest but statistically significant difference, whereas FAZ area and circularity index remained comparable between groups. No participant in either group exhibited clinically visible retinal pathology. These alterations occurred despite preserved visual acuity and in the absence of systemic comorbidities known to affect microcirculation.</p><p><strong>Conclusion: </strong>Although causality cannot be inferred from this cross-sectional design, our findings indicate that pelvic endometriosis is associated with region-specific subclinical reductions in retinal capillary perfusion, particularly within the foveal and parafoveal regions. OCTA-derived metrics, especially FD-300 and parafoveal VAD, may offer insight into microvascular integrity in this patient group. These results support further investigation into the systemic vascular aspects of endometriosis and highlight the potential utility of retinal imaging in exploring such associations.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"343"},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of body image perception and quality of life of women with segmental or total mastectomy: a cross-sectional study.","authors":"Behire Sançar, Nazife Akan, Nalan Süren Akpolat, Şirin İnanç","doi":"10.1186/s12905-025-03898-7","DOIUrl":"10.1186/s12905-025-03898-7","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"342"},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DMPA-SC self-injection experiences of clients and providers in Uganda: the role of community health workers in reproductive self-care service delivery.","authors":"Jane Cover, Allen Namagembe, Barbara Kunihira, Cecilia Nantume, Andrew Secor, Fiona Walugembe","doi":"10.1186/s12905-025-03850-9","DOIUrl":"10.1186/s12905-025-03850-9","url":null,"abstract":"<p><p>Accelerating task sharing for family planning and contraceptive self-care can minimize the impact of a projected shortage of 18 million health care workers by 2030. This cross-sectional study assessed the potential of community health workers (CHWs) to offer family planning counseling and self-injection training comparable in quality to that provided by clinic health workers. The study employed exit interviews with 240 injectable clients and 80 of the providers who conducted their counseling, from 43 purposively selected public sector clinics across eight districts of Uganda. The study examined the feasibility, acceptability, and quality of contraceptive service delivery, including self-injection training for women interested in self-care. The study also measured awareness and interest in self-injection among women and assessed provider receptivity to offering self-injection. Data was analyzed using STATA 14.2, using chi square and t-tests to measure for any bivariate significant differences at conventional significance levels for two-sided tests (p < .05). Results from interviews with injectable clients revealed a high level of interest in self-injection, ranging from 48 to 80% depending on the metric used. With respect to the quality of family planning counseling, interviews with clients indicate that CHWs provide a higher quality of care than that offered by their clinic-based counterparts, whether measured by the method information index plus (MII +) or the Quality of Contraceptive Counseling (QCC) scale. In terms of self-injection training, CHWs were significantly more likely to conduct individual training, ensure private time with the client (if trained in a group), show the client a job aid, and advise on disposal. In terms of receptivity to self-injection, both groups of providers expressed favorable views in general, though a substantial share would place restrictions on who can self-inject, limiting access for covert users (41%), adolescents (49%), and new users (58%). CHWs self-reported as better able to accommodate the time required for high quality family planning counseling and self-injection training. The findings from this study should reassure stakeholders that, when provided with appropriate, competency-based training and supervision, CHWs can help to fill a looming human resource shortfall, reinforcing family planning service delivery while reaching women who face profound geographic access challenges.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 Suppl 1","pages":"341"},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between daily sitting time and breast cancer among obese women: a nationwide population-based study.","authors":"Lizhen Wang, Cuiwei Lai, Zhipeng Wu, Haoyue Luo, Tai Xu","doi":"10.1186/s12905-025-03894-x","DOIUrl":"10.1186/s12905-025-03894-x","url":null,"abstract":"<p><strong>Background: </strong>We aimed to explore the association between daily sitting time and breast cancer in obese women, and further examine the mitigating role of physical activity in this relationship.</p><p><strong>Materials and methods: </strong>A secondary analysis of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 1999-2020 were used. Subjects were divided into four groups based on the duration of daily sitting time (< 4, 4 to 6, 6 to 8, and > 8 h). Survey-based logistic regression models, smooth curve fitting, subgroup analysis and sensitivity analysis were conducted.</p><p><strong>Results: </strong>A total of 9706 obese females (mean age 50.28 years) were included in the study. Breast cancer was reported by 271 (2.8%) individuals. In the fully adjusted model, compared with those with < 4 h of daily sitting time, ORs (95%CI) for breast cancer were 1.61 (95%CI: 1.41-5.33, p = 0.001) in group with 4 to 6 h of sitting, 1.86 (95%CI: 1.35 to 4.52) in group with 6 to 8 h, and 2.21 (95%CI: 1.36-4.95, p = 0.008) with > 8 h per day. Of note, the detrimental effects of prolonged sedentary behavior on increased prevalence of breast cancer were only found in physically inactive group, but not in physically active group. Smooth curve fitting showed a positive dose-response relationship between daily sitting time and breast cancer in total participants and physically inactive group. Furthermore, obese women aged 60 years or older, non-Hispanic white, and with more than a high school education, post-menopause, and with higher obesity levels were more likely to be affected by sedentary behavior.</p><p><strong>Conclusion: </strong>Prolonged daily sitting time is associated with increased prevalence of breast cancer in obese women and being physically active may mitigate this association. Prospective studies are needed to further examine this association.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"337"},"PeriodicalIF":2.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}