BMC Women's Health最新文献

{"title":"Inflammatory status and clinical phenotypes of PCOS: the role of NLR, SII, SIRI, and AISI.","authors":"Halis Doğukan Ozkan, Merve Ayas Ozkan, Ruken Dayanan, Dilara Duygulu Bulan, Ahmet Arif Filiz, Yaprak Engin-Ustun","doi":"10.1186/s12905-025-04033-2","DOIUrl":"10.1186/s12905-025-04033-2","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder in women of reproductive age, often associated with low-grade chronic inflammation. This study aimed to investigate the relationship between composite inflammatory markers-Neutrophil-to-Lymphocyte Ratio (NLR), Systemic Immune Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Aggregate Index of Systemic Inflammation (AISI)-and clinical phenotypes of PCOS, including oligo-/amenorrhea, hyperandrogenism, and polycystic ovarian morphology (PCOM). METHODS : In this retrospective cross-sectional study, women with PCOS were categorized into subgroups based on clinical phenotypes. Composite inflammatory markers were calculated from complete blood count parameters, and their association with clinical, hormonal, and ultrasonographic findings was analyzed. ROC analysis assessed the discriminatory value of each marker.</p><p><strong>Results: </strong>Inflammatory markers were significantly higher in the oligo-/amenorrhea and PCOM groups. In oligo-/amenorrhea, NLR (2.42 vs. 1.96, p = 0.028), AISI (282.16 vs. 188.73, p = 0.005), SII (664.59 vs. 519.86, p = 0.008), and SIRI (0.97 vs. 0.70, p = 0.005) were elevated. In PCOM, NLR (2.85 vs. 2.25, p = 0.025), AISI (323.15 vs. 262.78, p = 0.049), SII (738.52 vs. 641.27, p = 0.030), and SIRI (1.10 vs. 0.90, p = 0.046) were also higher. AISI showed the best discrimination for oligo-/amenorrhea (AUC = 0.652), while NLR was most predictive for PCOM (AUC = 0.617).</p><p><strong>Conclusions: </strong>Composite inflammatory markers are elevated in specific PCOS phenotypes, especially oligo-/amenorrhea and PCOM, and may reflect low-grade inflammation. These markers may help identify patients at higher cardiometabolic risk and guide preventive strategies.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"463"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Chinese patients' views on endometriosis surgery and fertility preservation in the context of declining fertility.","authors":"Que Wu, Yongfang Li, Xiaoqi Li, Ling Shen","doi":"10.1186/s12905-025-04006-5","DOIUrl":"10.1186/s12905-025-04006-5","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"450"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screens and society: how media narratives influence fertility and reshape childbearing choices; a systematic review.","authors":"Fatemeh Hadadian, Mina Abbasi, Tahereh Parsajam, Arezoo Haseli, Negin Rostami","doi":"10.1186/s12905-025-03986-8","DOIUrl":"10.1186/s12905-025-03986-8","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"457"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pharmacist-led educational services in promoting breast cancer awareness.","authors":"Nazish Mehmood, Amjad Khan, Sameen Abbas, Saima Mushtaq, Yu Fang, Muhammad Ans, Fakhar-Ud-Din, Gul Majid Khan","doi":"10.1186/s12905-025-04035-0","DOIUrl":"10.1186/s12905-025-04035-0","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is rapidly increasing worldwide. Pakistan has a high incidence rate of one in every nine women. The lack of awareness is the major reason for delayed diagnosis, thus resulting in high mortality. This study aimed to assess the impact of pharmacist-led breast cancer education at community pharmacies on promoting breast cancer awareness.</p><p><strong>Methodology: </strong>A longitudinal pre-post intervention study was conducted on 319 participants using a self-designed questionnaire. During the pre-intervention phase, data were collected from participants at various community pharmacies employing questionnaire administration. The provision of a breast cancer educational session followed the session. After three months, the participants were contacted via telephone, and the questionnaires were filled in again during the post-intervention phase. Data was analyzed using SPSS version 25.</p><p><strong>Results: </strong>The pre-post phase data evaluation reported improved breast cancer awareness among the study participants, with a significant increase (p = 0.000) in awareness of breast cancer symptoms, risk factors, and diagnostic techniques. There was a statistical increase in breast self-examination practice during the post-intervention phase (2.5% to 93.8%). Knowledge about clinical breast examination improved from 8.5% (pre-intervention phase) to 84.4% (post-intervention phase). Additionally, understanding mammography as a vital screening technique improved significantly, with approximately 34.7% of eligible women having undergone mammography in the post-intervention phase.</p><p><strong>Conclusion: </strong>A notable improvement in breast cancer awareness and self-examination was observed through pharmacist-led education. Leveraging pharmacist-led services in community pharmacies could effectively contribute to breast cancer control efforts. Utilizing pharmacists nationwide could facilitate the implementation of comprehensive strategies to elevate public breast cancer awareness nationally.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"461"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet, oxidative stress, and the mediating role of obesity in postmenopausal women.","authors":"Hao Sun, Chen Liang, Bingli Zuo, Mengmeng Wang","doi":"10.1186/s12905-025-04026-1","DOIUrl":"10.1186/s12905-025-04026-1","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"458"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of gynecological cancers on women's marital satisfaction, spousal support, and quality of life: a cross-sectional comparative study.","authors":"Asiye Sena Aykol, Melike Dissiz","doi":"10.1186/s12905-025-04027-0","DOIUrl":"10.1186/s12905-025-04027-0","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"456"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation of vaginal flora and anxiety in perimenopause women: a prospective study.","authors":"Yan Ren, Zhenzhen Pan, Xin Zuo, Xueqin Jiang","doi":"10.1186/s12905-025-04019-0","DOIUrl":"10.1186/s12905-025-04019-0","url":null,"abstract":"<p><strong>Background: </strong>Perimenopausal women experience significant mental changes that affect their health and lives. Emerging evidence suggests that alterations in the vaginal microbiota may be associated with mental health symptoms through a potential vagina-brain axis. Here, we aimed to investigate the relation between anxiety in perimenopausal women and the changes in vaginal flora and identify the related factors of anxiety.</p><p><strong>Methods: </strong>A total of 120 perimenopausal women were included. Anxiety was diagnosed using a self-rating anxiety scale. Their sleep and life quality were evaluated using the Pittsburgh Sleep Quality Index and the World Health Organization Quality of Life BREF, respectively. Then, the vaginal flora of each participant was evaluated by an oil immersion lens and a bacterial vaginosis combine-test kit. The univariate logistic regression and Pearson's correlation coefficient were used for statistical analysis.</p><p><strong>Results: </strong>The results showed that 52 of the 120 participants were diagnosed with anxiety. Of these, 43 anxious participants had abnormal microbiome density and diversity, while all of the anxious participants had imbalanced vaginal microecology assessment and negative hydrogen peroxide. Leukocyte esterase (LE) and sialidase (SNA) activities were higher in anxious women than that in non-anxious women. The sleep and life quality were poor in anxious participants. The pH value, LE, SNA, and sleep score were positively related to anxiety, while flora density, diversity, H₂O₂ and life quality score were negatively related to anxiety, which were protective factors.</p><p><strong>Conclusion: </strong>Vaginal flora disorder is positively correlated with anxiety in perimenopausal women. These findings suggest that monitoring and modulating vaginal microbiota may help early identify or manage anxiety in perimenopausal women.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"459"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of retained products of conception in a tertiary centre: a 20-year retrospective cohort study.","authors":"Gregor Prša, Tamara Serdinšek, Branka Žegura Andrić","doi":"10.1186/s12905-025-03995-7","DOIUrl":"10.1186/s12905-025-03995-7","url":null,"abstract":"<p><strong>Background: </strong>Retained products of conception (RPOC) are defined as the persistence of trophoblastic tissue or placenta inside the uterine cavity after pregnancy. Management is challenging because there are no clearly defined diagnostic criteria, evidence-based guidelines, or treatment protocols. Our aim was to determine the success and complication rate of different methods of RPOC management at our tertiary centre in the last 20 years.</p><p><strong>Methods: </strong>We retrospectively collected data from patients with RPOC treated in our Clinic from 2003 to 2021 in three-year intervals. The following data were obtained: age, type of RPOC, type of treatment, complications, histopathological evaluation of the acquired tissue, and the need for transfusion.</p><p><strong>Conclusions: </strong>Our study shows that hysteroscopy and D&C are highly successful methods of RPOC, however, the complication rate in D&C is significantly higher. Moreover, less invasive treatment of RPOC using expectant and medical approach is plausible, especially in asymptomatic patients.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"440"},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep infiltrating endometriosis: retroperitoneal endometriosis-a case report.","authors":"Hong Xu, Huiying Qian, Yu Zheng, Ruyue Ma, Ruiheng Zhao, Jian Chen","doi":"10.1186/s12905-025-03981-z","DOIUrl":"10.1186/s12905-025-03981-z","url":null,"abstract":"<p><strong>Background: </strong>Deep infiltrating endometriosis is a subtype of endometriosis. A case of retroperitoneal endometriosis surrounding the ureter and forming a pelvic mass is relatively rare.</p><p><strong>Case presentation: </strong>A 26-year-old woman was admitted to our department because of unbearable dysmenorrhea and dizziness. CT scan revealed a pelvic mass on the right side of the pelvic cavity. The pain did not alleviate even she received symptomatic treatments. She finally underwent a emergency laparoscopic exploration and a pelvic mass surrounding the right ureter was found during the surgery. We removed the mass successfully with the help of a urologist by inserting a right ureteral stent at last. A retroperitoneal endometriosis was diagnosed by postoperative pathology and GnRh was administered afterwards to prevent reoccurrence.</p><p><strong>Conclusion: </strong>We herein present a rare case of DIE-a retroperitoneal endometriosis and describe the process of the laparoscopic management. For retroperitoneal masses closely adherent to the pelvic wall, clarifying the course of the ureter is of great importance, and collaboration with urologic surgeons may be necessary when needed. Because there is no-specific imaging features, the benign or malignant nature of the mass might be suspected before surgery.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"441"},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors for dysmenorrhea, heavy menstrual bleeding, and premenstrual syndrome in adolescent schoolgirls in Sudan.","authors":"Yasir Salih, Ahmed A Hassan, Nadiah AlHabardi, Ishag Adam","doi":"10.1186/s12905-025-03993-9","DOIUrl":"10.1186/s12905-025-03993-9","url":null,"abstract":"<p><strong>Background: </strong>Menstrual problems are one of the leading health issues worldwide. We aimed to investigate the prevalence and associated factors of heavy menstrual bleeding (HMB), dysmenorrhea, and premenstrual symptoms (PMS) in adolescent schoolgirls in Almatamah, Sudan.</p><p><strong>Methods: </strong>A questionnaire was used to collect sociodemographic data, menstrual cycle parameters, and accompanying symptoms. We also measured girls' body mass index (BMI) and hemoglobin levels. Multivariate binary regression was performed.</p><p><strong>Results: </strong>Of the 162 girls surveyed, 21.0% had HMB, 56.8% had dysmenorrhea, and 30.2% had PMS. 13% of the girls reported that the symptoms interfered with their daily activities, and 17.3% reported seeking medical attention. In logistic regression analysis, increasing gynecological age was associated with HMB [adjusted odds ratio (AOR) = 1.69, 95% confidence interval (CI) = 1.20-2.38), and dysmenorrhea (AOR = 1.55, 95% CI = 1.12-2.14). Gynecological age was not associated with PMS, seeking medical attention, and interference with daily activities. Chronological age, maternal education, and BMI were not associated with menstrual abnormality.</p><p><strong>Conclusions: </strong>Overall, the prevalence of dysmenorrhea, PMS, and HMB was high in Sudanese adolescent school girls but lower than most studies from other countries. We recommend encouraging female adolescents to chart their menstrual pattern and implementing education and counselling towards the reproductive health issues.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"445"},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}