BMC Women's Health最新文献

{"title":"Serum creatinine as a risk factor for endometriosis: insights from cross-sectional study, mendelian randomization analysis, and diagnostic model study.","authors":"Yanan Duan, Yiqing Peng, Aiping Chen","doi":"10.1186/s12905-025-03808-x","DOIUrl":"10.1186/s12905-025-03808-x","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis (EM) is a prevalent gynecological condition impacting roughly 10% of women of reproductive age worldwide, causing chronic pain, infertility, and menstrual irregularities. Traditional diagnosis typically relies on invasive surgical methods, and non-invasive diagnostic techniques remain underdeveloped. This study seeks to investigate the association between creatinine levels and endometriosis through cross-sectional analysis and mendelian randomization (MR) analysis, while also developing and assessing diagnostic models.</p><p><strong>Method: </strong>This research integrates data from the NHANES database (1999-2006) and the affiliated hospital of Jining Medical College in China. The study cohort consists of women aged 20-60, with data collection covering age, race, education level, marital status, family income, weight, height, body mass index(BMI), and serum creatinine levels. Logistic regression models were used for univariate and multivariate analyses. Bidirectional MR analysis, utilizing genetic variation data from Large Genome Association Studies (GWAS), was performed to evaluate causal relationships using the inverse variance weighted (IVW) method, complemented by sensitivity analysis. A diagnostic model based on data from top-tier hospitals in China was constructed and its performance assessed through receiver operating characteristic(ROC) curves, area under the curve(AUC) values, and calibration curves.</p><p><strong>Result: </strong>In the NHANES dataset, univariate analysis indicated a significant correlation between creatinine levels and endometriosis (OR = 1.01, 95% CI: 1.00-1.01, P = 0.0048), while multivariate analysis maintained significant results after adjustment (OR = 1.00, 95% CI: 1.00-1.01, P = 0.0431). Bidirectional MR analysis demonstrated a causal relationship between creatinine levels and endometriosis, with a positive IVW result of 1.001 (95% CI: 1.00-1.002, P = 0.0350). In the chinese tertiary hospital dataset, the AUC for the diagnostic model on both training and validation sets were 0.721 and 0.730, respectively. An increase of 10 μmol/L in creatinine levels raised the risk of endometriosis by approximately 8% (OR = 1.08, 95% CI: 1.07-1.09, P < 0.001).</p><p><strong>Conclusion: </strong>This study establishes a significant link between creatinine levels and endometriosis, confirming creatinine as an independent risk factor. Elevated creatinine levels could be used as non-invasive biomarkers for the early detection and diagnosis of endometriosis. Future research should aim to validate these findings in larger, multicenter studies and delve into the specific biological mechanisms, paving the way for novel therapeutic strategies.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"277"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary intracranial immature teratoma in an adult woman: case report and literature review.","authors":"Yulun He, Haifeng Ran, Xiaojiao He, Daoen Zhang, Junwei Liu, Guiqin Chen, Qian E Yu, Yuxin Xie, Tijiang Zhang","doi":"10.1186/s12905-025-03815-y","DOIUrl":"10.1186/s12905-025-03815-y","url":null,"abstract":"<p><strong>Background: </strong>Primary immature teratoma of the parietal lobe is an exceptionally rare intracranial germ cell tumor, accounting for < 1% of all primary intracranial malignancies. Due to its rarity and overlapping radiological features with other tumors, such as glioma, immature teratomas are often misdiagnosed. Here, we report the case of a 48-year-old woman with a parietal lobe immature teratoma, initially misdiagnosed as a \"glioma,\" highlighting the diagnostic challenges and management strategies.</p><p><strong>Case presentation: </strong>A 48-year-old woman presented with progressive headaches. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a space-occupying lesion in the right parietal lobe with inhomogeneous density, distinct margins, and perilesional edema. Initial radiological interpretation suggested a glioma; however, postoperative histopathological examination confirmed the diagnosis of an immature teratoma. Following the first surgery, the patient underwent radiotherapy. Eight months later, MRI detected tumor recurrence, prompting a second surgical resection. The patient had an uneventful recovery and was discharged.</p><p><strong>Conclusions: </strong>This case underscores the diagnostic and therapeutic challenges of intracranial immature teratomas in adults. Key radiological features include: CT: Inhomogeneous density with fatty components and /or calcifications. MRI: Mixed signal intensity, perilesional edema, and contrast-enhanced annular enhancement with an enhancing mural nodule. Early and accurate diagnosis is critical for optimizing treatment outcomes. Surgical resection remains the cornerstone of management, with adjuvant therapies reserved for recurrent or residual disease. Clinicians should consider immature teratoma in the differential diagnosis of atypical brain parenchymal masses, particularly when imaging findings include inhomogeneous density on CT and mixed signals with annular enhancement on MRI.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"275"},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized trial to evaluate the impact of breast density notification on anxiety, breast cancer worry, and perceived risk among Latinas at a federally qualified health center : Breast density notification and anxiety, breast cancer worry, and perceived risk among Latinas.","authors":"Karthik Ghosh, Sarah M Jenkins, Jennifer L Ridgeway, Jessica D Austin, Bijan J Borah, Bhavika Patel, Deborah J Rhodes, Aaron D Norman, Edna P Ramos, Matt Jewett, Crystal R Gonzalez, Valentina Hernandez, Davinder Singh, Celine M Vachon, Vera J Suman","doi":"10.1186/s12905-025-03818-9","DOIUrl":"10.1186/s12905-025-03818-9","url":null,"abstract":"<p><strong>Background: </strong>Laws mandating that women be informed of mammographic breast density (MBD) with their mammogram results may increase anxiety. We report on changes in self-reported levels of anxiety, worry about developing breast cancer (BC), as well as perceived risk of BC resulting from three MBD notification methods: usual care (mailed notification letter), enhanced care (usual care with MBD educational brochure), or interpersonal care (enhanced care with promotora education), among a Latina population.</p><p><strong>Methods: </strong>A randomized controlled clinical trial of three MBD notifications was performed among Latina women aged 40 to 74 years receiving screening mammography at a federally qualified health center (FQHC). Measures of anxiety, BC worry and perceived lifetime BC risk were assessed using a questionnaire. Anxiety was measured using the State-Trait Anxiety Inventory scale (STAI-S). The question: \"How frequently do you worry about getting breast cancer someday\" assessed BC worry. perceived lifetime risk of BC was rated between 0% (no chance) to 100% (definitely will get). Additional surveys were completed at two weeks to six months (T1) and one year (T2) after the intervention.</p><p><strong>Results: </strong>1332 Latina women were randomized between October 2016 and October 2019. At T0, 51.8% had moderate or severe anxiety. BC worry was reported to be sometimes/ often/ almost all the time among 41.3% of participants. 25.4% reported a perceived lifetime risk of developing BC of > 10%, compared with 6.6% with Gail model estimated lifetime risk score of > 10%. There was no significant difference in the proportion of patients who maintained low or had decrease in their levels of anxiety, BC worry or perceived risk from T0 to either T1 or T2 surveys between intervention groups.</p><p><strong>Conclusion: </strong>This Latina cohort had high levels of anxiety and BC worry which persisted regardless of intervention received. Future work is needed to improve our understanding of factors that could lower anxiety and BC worry and improve BC risk perception in this population.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, NCT02910986. Registered on 22/09/2016.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"274"},"PeriodicalIF":2.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Logistic and time burdens reported by gynecologic and breast cancer survivors.","authors":"Allison C Dona, Aisha Ambo, Patricia Jewett, Katherine Brown, Helen Parsons, Arjun Gupta, Deanna Teoh, Anne Blaes, Rachel I Vogel","doi":"10.1186/s12905-025-03826-9","DOIUrl":"10.1186/s12905-025-03826-9","url":null,"abstract":"<p><strong>Background: </strong>We assessed the effect of the time requirements of cancer care on other life activities and time burden reduction priorities among breast and gynecologic cancer survivors.</p><p><strong>Methods: </strong>A total of 224 participants with gynecologic or breast cancer from two cohort studies completed a cross-sectional survey regarding logistic and time burdens of cancer care. We compared agreement with the importance of minimizing travel time, wait time, and trips to the cancer center as well as whether cancer care visits interfered with other activities (dependent care, chores, leisure activities) by employment, education, cancer type, cancer treatment status, dependent status, rural-urban residence, and income.</p><p><strong>Results: </strong>About half (108/217, 49.8%) of participants agreed minimizing time burdens was important. Some agreed that cancer care visits interfered with leisure time (31/215, 14.4%) or impacted their ability to care for dependents (17/215, 7.9% [15.9% among those with dependents, 7/44]). Retired participants, compared to working participants, less often agreed with the importance of minimizing travel time (36.5% [31/85] versus 58.0% [58/100]), trips to the cancer center (34.5% [30/87] versus 58.0% [58/100]), and wait time (35.8% [29/81] versus 56.0% [56/100]). Participants with incomes <$50,000 and those receiving maintenance treatment most often agreed that minimizing wait time was important. Those not working (and not retired or on disability) and those receiving active treatment most often agreed that care interfered with leisure activities.</p><p><strong>Conclusions: </strong>Minimizing the time needed for cancer care-related tasks matters to patients, especially to those with lower incomes, receiving treatment, and working. In-depth research among demographically diverse populations is needed to evaluate specific time use patterns within cancer care and their association with objective and subjective burden.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"273"},"PeriodicalIF":2.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing use of eau recommendations in diagnostic and therapeutic strategies for chronic pelvic pain syndrome: a case vignette study on dutch pelvic floor physiotherapists practices.","authors":"Myrthe Wissing, Marian Rombouts, Monique Steegers, Kris Vissers, Selina van der Wal, Kim Notten","doi":"10.1186/s12905-025-03782-4","DOIUrl":"10.1186/s12905-025-03782-4","url":null,"abstract":"<p><strong>Background: </strong>Chronic Pelvic Pain Syndrome (CPPS) presents as pain located in the pelvic area lasting for at least six months, often with a multifactorial aetiology. The International Continence Society divides CPPS in multiple domains; one is the musculoskeletal domain. Pelvic floor physiotherapy is a recommended treatment and is advised in the European Association of Urologist (EAU) guidelines. However, in the Netherlands, it is unclear which treatment strategies are used by pelvic floor physiotherapists (PFPs) for CPPS patients due to the lack of a Dutch evidenced-based guideline for physiotherapists. This study provides an overview of the adherence to the EAU guideline by PFPs in managing CPPS patients.</p><p><strong>Methods: </strong>A case vignette study using two case vignettes and a general questionnaire defining contextual data. Participants were PFPs treating patients with CPPS in primary care. We contacted 550 qualified PFPs registered in the Dutch national quality registry for physiotherapy.</p><p><strong>Main outcome measure: </strong>first, adherence to EAU guidelines and second, the adherence compared to level of education and caseload.</p><p><strong>Results: </strong>Of the invited participants, 198 completed the survey. Of these, 29 (14.6%) scored higher than 80% for both case vignettes; fifty-four (27%) scored 80% for the male case vignette and 30 (15%) scored 80% for the female case.</p><p><strong>Conclusions: </strong>Our findings show low adherence to the EAU guideline's proposed diagnostic and treatment criteria. PFPs should become more familiar with implementation of this guideline.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"272"},"PeriodicalIF":2.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"He showed me a knife and said they would kill me and no one would know or care\": a qualitative study into the experiences of transnational sex workers in Ghana.","authors":"Abdul-Hanan Saani Inusah, Andrew Mpagwuni Ziblim, Michael Boah","doi":"10.1186/s12905-025-03816-x","DOIUrl":"10.1186/s12905-025-03816-x","url":null,"abstract":"<p><strong>Background: </strong>Sex work in Ghana is deeply intertwined with economic hardship, criminalization, and social stigma, which subjects female sex workers (FSWs) to significant vulnerabilities. In Ghana, many FSWs, particularly immigrants, face compounded challenges, including physical and sexual abuse, police harassment, and discrimination, which are exacerbated by their migrant status. This study aims to address the gap in understanding the specific lived experiences of transnational FSWs in Ghana, with a focus on the intersection of gender, migration, and economic vulnerability.</p><p><strong>Methods: </strong>This study utilized a qualitative phenomenological approach to explore the lived experiences of transnational FSWs in Ghana's two largest cities, Accra and Kumasi. Participants were purposively selected through snowball sampling technique until thematic saturation was achieved, interviewing fourteen FSWs. In-depth interviews were conducted in English. Data collection took place in November and December 2024, with basic demographic data gathered at the beginning of each interview, and thematic analysis was employed to analyze the anonymized transcripts.</p><p><strong>Results: </strong>Economic necessity was the primary driver behind migration and entry into sex work for FSWs, with many revealing that promises of legitimate employment often led to coerced involvement into the trade. Participants also reported high levels of violence, including physical assault, theft, and sexual coercion from clients, often in isolated locations. They also experienced harassment and exploitation by law enforcement, which compounded their vulnerability. Additionally, discrimination based on nationality also exacerbated their vulnerability, as foreign FSWs were often treated more harshly than their Ghanaian counterparts by clients, police, and the public.</p><p><strong>Conclusion: </strong>This study's findings highlight the urgent need for comprehensive policy reforms that address the root causes of migrant sex work, including better economic opportunities for women and the decriminalization or regulation of sex work to protect sex workers from the risks associated with its illegal status, such as police harassment, exploitation, and lack of legal protections.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"266"},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postural control impairments following neurotoxic chemotherapy in women with cancer: a prospective observational study.","authors":"Aline Reinmann, Alexandre Bodmer, Thibaud Koessler, Joseph Gligorov, Anne-Violette Bruyneel","doi":"10.1186/s12905-025-03790-4","DOIUrl":"10.1186/s12905-025-03790-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare changes in postural control in different testing conditions involving sensory disturbances, quality of life and neurotoxicity concerns in women with cancer before and after chemotherapy with taxanes. The second aim was to compare postural control between chemotherapy-induced peripheral neuropathy (CIPN) severity subgroups.</p><p><strong>Method: </strong>The 33 participants with breast cancer (age 48.15 ± 9.88 years) were tested during the month preceding (baseline) and the month after the end of chemotherapy. Postural control was assessed on a force platform (100 Hz) in different conditions: eyes open/closed, rigid/foam surface, with/without tendon vibration, dual task, and limits of stability. CIPN severity and neurotoxicity concerns were also evaluated. Paired t-tests or Wilcoxon sign rank tests were used, and a Benjamini-Hochberg correction was applied.</p><p><strong>Results: </strong>After chemotherapy, greater postural adjustments were required to maintain balance in the reference condition (p ≤ 0.02), and in conditions with visual (p ≤ 0.02), foam (p ≤ 0.04), and dual task disturbances (p ≤ 0.01), but not in the vibration and limits of stability conditions. No difference was found between the CIPN subgroups. The neurotoxicity score worsened after chemotherapy (-8.61 ± 7.53, p ≤ 0.01).</p><p><strong>Conclusions: </strong>Postural control was impaired after chemotherapy, particularly in conditions with visual disturbances and dual task. Anteroposterior center of pressure displacements with mediolateral ground reaction forces were particularly increased.</p><p><strong>Clinical implications: </strong>Systematic assessment of postural control with eyes closed in women with breast cancer would help to identify chemotherapy-induced postural control disorders and determine treatment needs.</p><p><strong>Trial registration: </strong>Clinical Trial Registration number NCT04692168. Registration date: 28.12.2020.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"269"},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of an intervention package to alleviate the psychological effects of premenstrual syndrome in adolescent girls.","authors":"Hannah Asadi, Hossein Ghamari Kivi, Zahra Akhavi Samarein","doi":"10.1186/s12905-025-03690-7","DOIUrl":"10.1186/s12905-025-03690-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and evaluate the effectiveness of a therapeutic package combining Cognitive Behavioral Therapy (CBT), Narrative Therapy, and a gender-sensitive approach to reduce the psychological and emotional challenges of Premenstrual Syndrome (PMS) in adolescent girls.</p><p><strong>Methodology: </strong>Using a quasi-experimental design, 30 adolescent girls from Saqqez, Iran, were randomly assigned to an intervention group (n = 15) or a control group (n = 15). The intervention group participated in a researcher-developed group therapy program over 10 sessions, focusing on reducing rumination and pain-related catastrophic thinking. Assessments were conducted pre-test, post-test, and at follow-up using validated psychological scales. Data were analyzed using ANCOVA.</p><p><strong>Results: </strong>The intervention significantly reduced rumination and pain catastrophizing in the experimental group compared to the control group (p < 0.05). These effects were sustained at follow-up, indicating the intervention's lasting impact on improving cognitive and emotional regulation.</p><p><strong>Conclusion: </strong>The findings demonstrate that a therapeutic package integrating CBT, Narrative Therapy, and cultural sensitivity can effectively alleviate PMS-related psychological symptoms in adolescent girls. This approach holds promise for broader applications in educational and counseling settings to enhance adolescent well-being.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"271"},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's satisfaction with health extension services and its associated factors in Hawassa City, Sidama region, Southern Ethiopia.","authors":"Bargude Balta, Zufan Ayele","doi":"10.1186/s12905-025-03824-x","DOIUrl":"10.1186/s12905-025-03824-x","url":null,"abstract":"","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"270"},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in participation for young women after breast cancer diagnosis and treatment: a qualitative study.","authors":"Amy Roder McArthur, Susan Magasi, Tamara Hamlish, Cassandra A Winters, Joy Hammel","doi":"10.1186/s12905-025-03814-z","DOIUrl":"10.1186/s12905-025-03814-z","url":null,"abstract":"<p><strong>Background: </strong>Though there is increasing attention to the experiences of young breast cancer survivors, there is a need to further examine participation changes for this population after active treatment. This study aimed to examine how person-environment interactions mediate young breast cancer survivors' participation in life, focusing on features of disability within breast cancer survivorship.</p><p><strong>Methods: </strong>This qualitative study utilized a series of two semi-structured interviews to explore the experiences of nine women diagnosed with early-stage breast cancer at or below the age of forty-five. Interpretative phenomenological analysis was used to analyze interviews.</p><p><strong>Results: </strong>Three cross-case themes were identified: (1) Nothing untouched: changes in self (2), Cancer is \"not over\": the influences of social environment on survivorship, and (3) Gaps in services and supports: systems level influences on participation.</p><p><strong>Conclusions: </strong>Participants' participation changes were shaped by environmental factors, such as the complexity of healthcare system navigation. Participants pointed to a need to connect young survivors with services and supports to improve opportunities for participation in daily life following breast cancer diagnosis and treatment. This aligns with conceptualizations of disability that identify the environment as a major driver of restricted participation for disabled people. Late effects of breast cancer impact participation and should be routinely addressed as part of cancer and survivorship care. Acknowledging disability as part of breast cancer survivorship can encourage breast cancer survivors to discuss their experiences openly and to ensure they receive the supports needed to participate fully in life.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"265"},"PeriodicalIF":2.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}