BMC Women's Health最新文献

{"title":"Uncommon metastatic journey: unusual breast metastases of medullary thyroid carcinoma: a case report.","authors":"Saadallah Fatma, Chrigui Maha, Zemni Ines, Kammoun Salma, Houcin Yoldez, Jbeli Souhail, Driss Maha, Ben Dhiab Tarak","doi":"10.1186/s12905-025-03564-y","DOIUrl":"10.1186/s12905-025-03564-y","url":null,"abstract":"<p><p>Medullary thyroid carcinoma is a neuroendocrine tumor derived from thyroid C-cells. It is a rare aggressive tumor, known to metastasize to lymph nodes, liver, bones, and lungs. We report a case of a young patient with a family history of breast cancer, who developed breast metastases six months post-treatment for medullary thyroid carcinoma. The breast lesion was initially considered benign in ultrasound. Unlike the high prevalence of primary mammary malignancies, metastases to the breast are uncommon, and account for only 0.2-2.7% of all malignancies affecting this organ. This case emphasizes the need for thorough and continuous monitoring of patients with Medullary thyroid carcinoma, even in unusual locations, to ensure early detection and appropriate management. New lesions on imaging should be interpreted with caution to avoid underdiagnosing metastasis. Immunohistochemical analysis confirmed the metastatic origin, underscoring the challenges in distinguishing between primary and secondary breast tumors. This case contributes to the limited literature on MTC breast metastases and advocates for heightened clinical awareness regarding atypical metastatic sites in thyroid cancer patients.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"29"},"PeriodicalIF":2.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression.","authors":"Xiaotong Chen, Kai Wei, Shanshan Peng, Na Liu, Leqi He, Biying Wu, Meifang Shi, Yong Lin","doi":"10.1186/s12905-025-03548-y","DOIUrl":"10.1186/s12905-025-03548-y","url":null,"abstract":"<p><strong>Background: </strong>It has been reported that the cognitive responses to physical activity (PA) in postmenopausal women vary by parity status, and women with higher parity show a significant association between PA and cognitive function. However, the potential pathways mediating the relationship between PA and cognitive function in women with higher parity remain unclear. The objective of this study was to examine this association in Chinese cohort and further investigate the mediating pathways.</p><p><strong>Methods: </strong>A total of 2296 postmenopausal women were enrolled from the Baoshan District, from April to December 2020. All participant information was collected through interviewer-administered questionnaires or measurements, including personal information, medical history, lifestyle, body mass index (BMI), cognitive function, nutritional status, and depression status. In this cross-sectional study, generalized linear regression models and the chain-mediation analysis were used to examine the relationship between PA and cognitive function and the mediating pathways.</p><p><strong>Results: </strong>There was a significant relationship between PA and cognitive function in the high-parity group (≥ three births). In the fully adjusted generalized linear regression model, PA was significantly associated with cognitive function [β: 0.795, 95% confidence interval (CI): 0.251-1.340, P < 0.05]. The chain-mediation analysis showed that depression and nutritional status were two significant mediators, contributing 37.96% of the indirect effect of the overall effect.</p><p><strong>Conclusions: </strong>Our findings suggest that PA is beneficial for women (≥ three births) to maintain cognitive function, and these benefits are mediated by depression and nutritional status.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"27"},"PeriodicalIF":2.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-port non-lipolytic endoscopic surgery via the axillary approach for the treatment of benign breast tumors has better clinical outcomes: a case control study.","authors":"Tianyi Ma, Jian Cui, Qian Wang, Changgen Liu, Bin Wang, Haibo Wang","doi":"10.1186/s12905-025-03563-z","DOIUrl":"10.1186/s12905-025-03563-z","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic surgery provides good cosmetic results while ensuring therapeutic outcomes. This study aimed to evaluate the efficacy, safety, and cosmetic outcome of endoscopic surgery for benign breast tumors.</p><p><strong>Methods: </strong>In total, 108 patients were enrolled and divided into endoscopic or open surgery groups based on the patients' voluntary decisions. Surgical information, complications, postoperative pain, and postoperative cosmetic scores were compared.</p><p><strong>Results: </strong>The endoscopic surgery group and open surgery group included 46 and 62 patients, respectively. Patients who underwent endoscopic surgery had longer operative times (p < 0.001) and postoperative hospital stays (p = 0.045), and there was no significant difference in intraoperative blood loss between the two groups (p = 0.501). The overall postoperative complication rate was 13% in the endoscopic group and 25.8% in the open group (p = 0.103). Postoperative pain scores were similar in both groups. Cosmetic scores were better in the endoscopic group (p = 0.002), especially regarding nipple shape and wound scarring.</p><p><strong>Conclusions: </strong>Endoscopic surgery is safe and effective for treating benign breast tumors and offers improved cosmetic results compared to open surgery.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"26"},"PeriodicalIF":2.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The meaning of trust along the treatment pathway of women with breast cancer: a mixed-methods study among cancer survivors.","authors":"Eleonore Baum, Daniela Bernhardsgrütter, Ramona Engst, Carola Maurer, Jessica Ebneter, Adrienne Zenklusen, Barbara Wartlsteiner, Lotti Barandun, Andrea Neher, Antje Koller, Andrea Kobleder","doi":"10.1186/s12905-024-03540-y","DOIUrl":"10.1186/s12905-024-03540-y","url":null,"abstract":"<p><strong>Purpose: </strong>Women with breast cancer face a high degree of uncertainty. Trust between health providers and patients has been shown to improve patient quality of life and may enhance clinical outcomes. This study aimed to explore the meaning of trust along the treatment pathway.</p><p><strong>Methods: </strong>The study followed a convergent mixed-methods design. We collected qualitative data longitudinally from diagnosis to follow-up using unstructured digital diaries and 45 semi-structured interviews with twelve women with breast cancer. To measure symptom burden and trust, we collected quantitative data by means of 57 questionnaires. Data analysis was based on phenomenology according to van Manen and on descriptive statistics. Data synthesis resulted in a conceptual model of trust.</p><p><strong>Results: </strong>The women experienced trust as a dynamic phenomenon within the biomedical cancer care \"machinery\". Their trust was strongly influenced by contextual factors, professionals' expertise, and person-centeredness. The relevance of trust differed according to treatment phases.</p><p><strong>Conclusions: </strong>Due to a high degree of uncertainty, trust was particularly important. Professionals positively influenced the women's trust to a certain extent through a patient-centered approach and by demonstrating expertise within the biomedical cancer care \"machinery\". The conceptual model of trust should receive attention to bring care closer to the women's lived experience so that their care experience can be improved.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"25"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and determinants of intimate partner violence against women in Somalia: evidence from the SDHS survey 2020 dataset.","authors":"Abdirizak Hassan Abokor, Omer Adam Farih, Mustafe Abdillahi Ali, Christophe Chesneau, Abdisalam Hassan Muse","doi":"10.1186/s12905-024-03539-5","DOIUrl":"10.1186/s12905-024-03539-5","url":null,"abstract":"<p><strong>Background: </strong>Intimate partner violence (IPV) is a pervasive issue across Sub-Saharan Africa and other developing countries, including Somalia. Understanding the prevalence and drivers of IPV against women is crucial for effective prevention and intervention efforts. However, limited research has focused on identifying these determinants specifically in the Somali context.</p><p><strong>Purpose: </strong>This study aims to identify the prevalence and key determinants of IPV in Somalia, including age groups, administrative regions, place of residence, educational level, household size, husband/partner's education and work, respondent's work, and total children ever born.</p><p><strong>Methods: </strong>Data from the Somali Demographic and Health Survey (SDHS) 2020 were analyzed. Univariate analysis, bivariate analysis and multivariable logistic regression models were used to assess the associations between the identified determinants and IPV.</p><p><strong>Results: </strong>The study found significant associations between several factors and IPV. Age, region of residence, type of residence, educational level, husband/partner's education and work, respondent's work, and total children ever born were identified as significant determinants of IPV in Somalia. Younger age groups, rural residence, lower educational attainment, unemployment of the husband/partner and respondent, and larger household size were associated with an increased risk of IPV.</p><p><strong>Conclusion and recommendations: </strong>The findings highlight the importance of addressing socio-demographic factors to effectively combat IPV in Somalia. Based on the results, recommendations include implementing comprehensive educational programs promoting gender equality and challenging traditional norms, enhancing economic opportunities for women and men, tailoring interventions to address regional disparities, strengthening the legal framework, and improving support services for IPV survivors. Future research should focus on longitudinal studies, qualitative research, intervention evaluation, multi-sectoral collaboration, and the impact of IPV on children. By addressing these recommendations and conducting further research, stakeholders can work towards preventing and reducing IPV in Somalia and other similar contexts.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"22"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum cytokine levels and postmenopausal depression in postmenopausal women with and without menopause hormone therapy.","authors":"Ketan Chu, Xi Lin, Saisai Li, Linjuan Ma, Yizhou Huang, Fan Wu, Mengna Shou, Nazaré Alva Galang Cabarrabang, Yibing Lan, Jianhong Zhou","doi":"10.1186/s12905-025-03560-2","DOIUrl":"10.1186/s12905-025-03560-2","url":null,"abstract":"<p><strong>Background: </strong>The etiology of depression involves many biological and environmental factors, among which the inflammatory process is an important contributor. However, the role of pro-inflammatory cytokines in postmenopausal depression is unclear. Therefore, we aimed to explore the association between the serum concentrations of four pro-inflammatory cytokines (IL-1β, IL-6, IL-18, and TNF-α) and depressive symptoms in postmenopausal women who had been receiving menopause hormone therapy (MHT) for at least 6 months and postmenopausal women who had not received MHT.</p><p><strong>Methods: </strong>This study included a total of 136 Chinese postmenopausal women aged 40 to 65 years who visited the gynecology outpatient department between June 2020 and December 2022. They were divided into the POST group (n = 94) and the POST + MHT (n = 42) group. Demographic information was collected, and the Hamilton Rating Scale for Depression (HAMD) was used to assess depression. The circulating levels of IL-1β, IL-6, IL-18, and TNF-α were determined using ELISA kits.</p><p><strong>Results: </strong>According to the HAMD score, 39.36% of the participants in the POST group and 14.29% in the POST + MHT group were considered to have depression. The POST + MHT group had significantly lower serum concentrations of IL-18 and TNF-α than the POST group. Multiple linear regression analysis showed that the serum IL-18 (β = 3.996, 95% CI = 0.508-7.484), and TNF-α levels (β = 4.784, 95% CI = 0.939-8.629) were significant predictors of the HAMD-24 scores in women in the POST group. In addition, age was found to be positively related with the level of depression (β = 0.531, 95% CI = 0.063-0.999).</p><p><strong>Conclusions: </strong>Postmenopausal women who received MHT had a lower HAMD-24 score as well as lower serum TNF-α and IL-18 levels than women who did not receive MHT. Further, the TNF-α and IL-18 level were positively associated with the HAMD-24 score in women who had not received MHT.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"24"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of family care on sleep quality in perimenopausal women: mediating roles of anxiety and depression.","authors":"Nana Liang, Jishun Ren, Juan Zhao, Xiaohui Liu, Haixia Zheng","doi":"10.1186/s12905-025-03551-3","DOIUrl":"10.1186/s12905-025-03551-3","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the relationship between family care, anxiety, depression, and sleep quality in perimenopausal women. Furthermore, it also aimed to examine the role of anxiety and depression in mediating family care and sleep quality. The study findings aim to provide theoretical support for alleviating anxiety and depression levels and improving sleep quality in perimenopausal women.</p><p><strong>Methods: </strong>Perimenopausal women (n = 860) in Gansu Province were surveyed using the self-rating scale of sleep, self-rating anxiety scale, self-rating depression scale, and family adaptation partnership growth affection resolve.</p><p><strong>Results: </strong>The sleep quality, anxiety, and depression scores of the perimenopausal women in Gansu Province were 25.33 ± 5.00, 40.74 ± 10.89, and 40.77 ± 10.03, respectively, and the family care score was 6.64 ± 2.36. Family care was negatively correlated with sleep quality, anxiety, and depression scores; anxiety was positively correlated with depression and sleep quality scores, and depression was positively correlated with sleep quality scores. Anxiety and depression in perimenopausal women partially mediated family care and sleep quality, with mediating effects accounting for 15.74% and 60.69% of the total effect, respectively.</p><p><strong>Conclusion: </strong>Anxiety and depression are mediating variables between family care and sleep quality in perimenopausal women. It is recommended that hospital and community staff pay attention to the role of good family care in perimenopausal women, actively implement intervention strategies aimed at reducing anxiety and depression pathways, and improve their sleep quality.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"19"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavior changes to promote preconception health: a systematic review.","authors":"Maiko Suto, Kimiko Inaoka, Daichi Suzuki, Aya Nitamizu, Naoko Arata, Erika Ota","doi":"10.1186/s12905-024-03544-8","DOIUrl":"10.1186/s12905-024-03544-8","url":null,"abstract":"<p><strong>Background: </strong>Preconception care is expected to prevent diseases, promote health, and improve pregnancy outcomes. Although a consensus exists on the efficacy of folic acid supplementation and preconception vaccination, evidence regarding comprehensive approaches to preconception care targeting the general population remains lacking. We aimed to identify and examine preconception care programs delivered to reproductive-aged women and men to promote behavioral change.</p><p><strong>Methods: </strong>We searched the MEDLINE, EMBASE, and CENTRAL databases on November 30, 2023. We included randomized controlled trials (RCTs) and cluster RCTs assessing preconception care programs provided to the general population. We included behavioral change interventions, including screening, counseling, and education, to encourage preconception health. We performed a narrative synthesis of the characteristics and a summary of the intervention effects of the included studies.</p><p><strong>Results: </strong>We identified 26 trials (from 29 reports). Most of the studies recruited women. The most common study setting was healthcare services, and various types of behavioral change interventions were noted. All types of interventions, including individual education, group education, online education, and information campaigns, exhibited certain effects of improvement regarding behavioral change, knowledge, health outcomes, and other health-related outcomes in preconception health.</p><p><strong>Conclusions: </strong>In this systematic review, only three studies recruited men. Further research on preconception care in men is needed. The topics typically addressed in preconception care are folic acid supplementation and nutrition. Additionally, further research is needed for a comprehensive approach, including physical, mental, and social health. Future research addressing the broad determinants of preconception health for both women and men could provide more effective preconception care.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"23"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of women relocated due to the february 2023 earthquake in Turkey: a qualitative study.","authors":"Esra Özer, Yeşim Çetinkaya Şen, Döndü Sevimli Güler, Gülten Güvenç","doi":"10.1186/s12905-025-03554-0","DOIUrl":"10.1186/s12905-025-03554-0","url":null,"abstract":"<p><strong>Background: </strong>Women are disproportionately affected by disasters due to their vulnerability and limited access to resources. The purpose of this study is to investigate the health concerns and experiences of women who relocated to a different city following the February 2023 earthquake in Turkey.</p><p><strong>Methods: </strong>Data was collected using a constructivist qualitative research design. Between May 1 and July 1 2023, interviews were conducted with female participants who relocated to a different city after the February 2023 earthquake in Turkey. The collected data underwent qualitative content analysis, adhering to the Standards for Qualitative Research Reporting (SRQR). The study utilized Graneheim and Lundman's content analysis method to analyze the interview data. Interviews were transcribed. The transcripts were analyzed in the qualitative research software package ATLAS.ti 9.</p><p><strong>Results: </strong>In the study, 32 women aged 19-43 years were interviewed. The results revealed four distinct categories and 10 sub-categories derived from the interviewees' narratives. These four categories were physiological needs, safety concerns, need for love and belonging, and self-realization.</p><p><strong>Conclusions: </strong>It was concluded that individuals who experience disasters face multiple hardships, especially related to these categories. Therefore, it is crucial to focus on the issues and requirements of survivors, particularly women belonging to vulnerable groups. One should not overlook the fundamental needs of women in service delivery.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"21"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocervical adenocarcinomas and HPV genotyping in an HIV endemic milieu - a retrospective study.","authors":"Lucília Lovane, Gabriella Lillsunde Larsson, Satish Tulsidás, Carla Carrilho, Sören Andersson, Christina Karlsson","doi":"10.1186/s12905-025-03555-z","DOIUrl":"10.1186/s12905-025-03555-z","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is the most prevalent cancer in Mozambique, with endocervical adenocarcinoma accounting for approximately 5.5% of cases. Knowledge regarding the most prevalent HPV genotypes in endocervical adenocarcinoma is limited, within this setting. This study aimed to investigate human papillomavirus (HPV) prevalence and genotypes within a cohort of endocervical adenocarcinoma patients in the context of Mozambique's recently introduced vaccination programme, considering the country's HIV-endemic setting.</p><p><strong>Methods: </strong>Forty consecutive cases of endocervical adenocarcinoma diagnosed at Maputo Central Hospital between 2017 and 2018, with limited clinical data available, were included. Human immunodeficiency virus (HIV) status was determined through serological data or in situ hybridisation on histopathological slides. HPV detection was performed using a multi-methodological approach, including Anyplex II, in-house polymerase chain reaction (PCR), and chromogenic and fluorescent in situ hybridisation techniques.</p><p><strong>Results: </strong>All 40 cases exhibited HPV-dependent morphology. Fourteen of the 40 patients were HIV-positive. No significant differences were observed between the two groups regarding age, stage, or histopathological type. hrHPV16, 18, or 45 were detected in all cases. Notably, multiple hrHPV infections were identified exclusively in HIV-negative cases (10/26, p = 0.0075), with hrHPV18/45 co-infection being the most common (n = 8).</p><p><strong>Conclusions: </strong>These findings suggest that the newly implemented quadrivalent vaccination programme has the potential to prevent morbidity and mortality from endocervical adenocarcinoma, irrespective of HIV infection status, in Mozambique's HIV-endemic environment.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"20"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}