BMC Women's Health最新文献

{"title":"Development and evaluation of a machine learning model for osteoporosis risk prediction in Korean women.","authors":"Minkyung Je, Seunghyeon Hwang, Suwon Lee, Yoona Kim","doi":"10.1186/s12905-025-03669-4","DOIUrl":"https://doi.org/10.1186/s12905-025-03669-4","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to develop a machine learning (ML) model for classifying osteoporosis in Korean women based on a large-scale population cohort study. This study also aimed to assess ML model performance compared with traditional osteoporosis screening tools. Furthermore, this study aimed to examine the factors influencing the risk of osteoporosis through variable importance.</p><p><strong>Methods: </strong>Data was collected from 4199 women aged 40-69 years in the baseline survey of the Ansan and Ansung cohort of the Korean Genome and Epidemiology Study. Osteoporosis was set as the dependent variable to develop ML classification models. Independent variables included 122 factors related to osteoporosis risk, such as socio-demographic characteristics, anthropometric parameters, lifestyle factors, reproductive factors, nutrient intakes, diet quality indices, medical history, medication history, family history, biochemical parameters, and genetic factors. The six classification models were developed using ML techniques, including decision tree, random forest, multilayer perceptron, support vector machine, light gradient boosting machine, and extreme gradient boosting (XGBoost). The six ML classification models were compared with two traditional osteoporosis screening tools, including the osteoporosis risk assessment instrument (ORAI) and the osteoporosis self-assessment tool (OST). The ML model performances were evaluated and compared using the confusion matrix and area under the curve (AUC) metrics. Variable importance was assessed using the XGBoost technique to investigate osteoporosis risk factors.</p><p><strong>Results: </strong>The XGBoost model showed the highest performance out of the six ML classification models, with an accuracy of 0.705, precision of 0.664, recall of 0.830, and F1 score of 0.738. Moreover, the XGBoost model showed a higher performance on AUC than ORAI and OST. Variable importance scores were identified for 69 out of the 122 variables associated with osteoporosis risk factors. Age at menopause ranked first in variable importance. Variables of arthritis, physical activities, hypertension, education level, income level; alcohol intake, potassium intake, homeostatic model assessment for insulin resistance; energy intake, vitamin C intake, gout; and dietary inflammatory index ranked in the top 20 out of the 69 variables, using the XGBoost technique.</p><p><strong>Conclusions: </strong>This study found that an XGBoost model can be utilized to classify osteoporosis in Korean women. Age at menopause is a significant factor in osteoporosis risk, followed by arthritis, physical activities, hypertension, and education level.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"146"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates and effects of information, motivation and behavioral skills on primary sexual abstinence among female university students in Ethiopia: a cross-sectional study.","authors":"Banti Negero Feyisa, Gurmessa Tura Debelew, Zewdie Birhanu Koricha","doi":"10.1186/s12905-025-03664-9","DOIUrl":"10.1186/s12905-025-03664-9","url":null,"abstract":"<p><strong>Background: </strong>The burden of sexually transmitted infections (STIs) and unintended pregnancies continue to pose significant public health challenges, disproportionately affecting young women. The information-motivation-behavioral (IMB) skills model is useful for understanding risky and safe sexual behavior. However, while the IMB models have been used primarly to understand and promote HIV prevention with condom use behavior, there is limtted research using the IMB model to understand and promote safer sexual dual-protection behaviors, such as abstinence, to address the risk of both STI/HIV and unwanted pregnancy among youth in Ethiopia. This study aimed to fill this gap by applying the IMB model to assess the correlates and effects of information, motivation, and behavioral skills on primary sexual abstinence among female university students in Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with a sample of 1,020 female university students at Mattu University between May and June 2023. Data were collected using a self-administered questionnaire and analyzed using SPSS version 23. Descriptive statistics were used to summarize the percentage distribution of participants by their sociodemographic characteristics and levels of HIV risk reduction/dual protection information, motivation, behavioral skills, and risky and safer sexual behaviors. Bivariate and multivariate analyses were conducted using structural equation modeling (SEM) with AMOS 23 to examine the correlations and effects of information, motivation, and behavioral skills on primary sexual abstinence.</p><p><strong>Results: </strong>Of 1,020 participants, 624 (61.2%) reported having practiced primary sexual abstinence.Multivariate analyses showed that primary sexual abstinence was significantly predicted by motivation (β = 0.34, P < 0.001), behavioral skills (β = 0.24, P < 0.001) and information (β = 0.11, P < 0.001) after controlling for the effects of other confounding variables. Overall, approximately 28% of the variance in primary sexual abstinence was explained by the IMB model constructs.</p><p><strong>Conclusions: </strong>The findings indicate that the IMB model is a useful tool for identifying powerful determinants of sexual abstinence, which has potential implications for interventions aimed at enhancing specific information, motivation, and behavioral skills to promote sexual abstinence and reduce the risk of HIV/STI and unintended pregnancy among youth in settings with high HIV burdens.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"144"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of human papillomavirus-related cervical lesions in postmenopausal women: a cross-sectional study.","authors":"Hongmin Zeng, Qianling Dai, Jieru Peng, Juan Li, Jing Chen, Zhipeng Lan, Xia Wu, Ting Shu, Liu Yang, Wenyi Lin, Mulan Li, Xiao Yang, Yonghong Lin","doi":"10.1186/s12905-025-03675-6","DOIUrl":"10.1186/s12905-025-03675-6","url":null,"abstract":"<p><strong>Background: </strong>The incidence of cervical cancer is increasing in postmenopausal women globally, particularly in less-developed nations, including China. However, research on cervical cancer screening methods and related factors in China is limited. In the present study, we aimed to identify the independent risk factors associated with cervical lesions in postmenopausal women. Additionally, we compared the clinical characteristics and demographic information between women diagnosed with low-grade squamous intraepithelial lesions (LSIL) and those with high-grade squamous intraepithelial lesions+ (HSIL+).</p><p><strong>Methods: </strong>We conducted a cross-sectional study using qualitative human papillomavirus (HPV) DNA testing for cervical cancer screening among postmenopausal women across 23 districts and counties in Chengdu, China. Multivariate logistic analysis was employed to analyze demographic information, clinical history, and auxiliary examinations to identify independent risk factors for cervical lesions in postmenopausal women.</p><p><strong>Results: </strong>A total of 917 patients participated in the study and were categorized as: 624 patients with LSIL (68.0%) and 293 patients with HSIL+ (32.0%). Multivariate analysis revealed that factors showing significant differences between two categories included co-infection with types 16 and 18 (adjusted odds ratio [aOR] = 0.348, 95% confidence interval [CI] = 0.138-0.881, p = 0.026), mixed infections involving other types, HPV 16/18 (aOR = 0.514, 95% CI = 0.336-0.785, p = 0.002), transformation zone (TZ) 3 (aOR = 1.604, 95% CI = 1.018-2.528, p = 0.041), and colposcopy impressions indicating high-grade features and worse (aOR = 11.846, 95% CI = 2.132-65.807, p = 0.005).</p><p><strong>Conclusions: </strong>Co-infection with HPV types 16 and 18, as well as mixed infections involving HPV 16/18 and other types, TZ 3, and colposcopic features indicative of high-grade lesions and cancer, were identified as independent risk factors for HPV-related cervical lesions in postmenopausal women. Therefore, postmenopausal women with these high-risk factors need to undergo frequent cervical screening, and histopathological examination, if necessary.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"143"},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HPV test results and emotional responses on psychosocial burden among Taiwanese women: a cross-sectional study.","authors":"Chia-Chun Li, Ting-Chang Chang, Chun-Hsia Huang, Chi-Wen Chang, Yun-Fang Tsai, Lynn Chen","doi":"10.1186/s12905-025-03627-0","DOIUrl":"10.1186/s12905-025-03627-0","url":null,"abstract":"<p><strong>Background: </strong>HPV is a sexually transmitted virus and is the cause of virtually all cervical cancers. Women undergoing HPV testing may experience significant psychosocial burdens, particularly those with a higher negative affect who test positive for the virus. This study investigates the relationships among test results, anxiety/depression, positive affect (PA), negative affect (NA), and psychosocial burden in women receiving their HPV test reports.</p><p><strong>Methods: </strong>This was a cross-sectional, observational study design. The data were collected after women received their HPV test reports. A total of 273 women were recruited for this survey study from June 2018 to April 2020 in a medical center in North Taiwan. Data were collected on an author-designed demographic-disease survey, the European Quality of Life Index Version 5D 5-Level-Anxiety/Depression, the International Positive and Negative Affect Schedule-Short Form, and the HPV Impact Profile questionnaire. Data were analyzed by descriptive statistics, independent-sample t-tests, analysis of variance, Pearson correlations, and hierarchical multiple linear regression models.</p><p><strong>Results: </strong>Among 273 women, 171 (62.6%) received HPV-positive results. Women with positive HPV test results reported significantly higher levels of anxiety/depression and NA compared to those with negative results. Additionally, those with positive results experienced greater psychosocial burden and worse sexual impact. Furthermore, age, NA, and PA were significant predictors of psychosocial burden in women who tested positive for HPV. Specifically, younger age, higher NA, and lower PA were significantly associated with increased psychosocial burden in women who received positive test results.</p><p><strong>Conclusion: </strong>Health-care providers should pay attention to the test results and women's emotional status, especially for women who have positive results and exhibit negative moods. To alleviate the psychosocial burden in women who have positive test results and high negative moods, professionals could provide timely HPV information and reserve time for women to ask questions, which could decrease their distress after receiving the report.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"142"},"PeriodicalIF":2.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and acceptability of a self-collected medical grade tampon as a novel vaginal sample collection tool for the detection of HPV and STIs.","authors":"Valentina Milanova, Iva Lazarova, Kalina Mihaylova, Michelle Gomes, Teodora Georgieva, Jan Multmeier","doi":"10.1186/s12905-025-03652-z","DOIUrl":"10.1186/s12905-025-03652-z","url":null,"abstract":"<p><strong>Objective: </strong>Cervical cancer remains a significant health concern, particularly in low-income and middle-income countries (LMICs). This study aims to compare the efficacy and suitability of a self-collected tampon for the detection of human papillomavirus (HPV) and sexually transmitted infections (STIs) using qualitative TMA-based assays (Transcription Mediated Amplification; APTIMA® HPV, APTIMA® Combo 2 (CT/NG; AC2 from now on) and APTIMA®Bacterial Vaginosis (BV from now on). Additionally, we assess the acceptability of tampons as a self-collection tool.</p><p><strong>Methods: </strong>A cohort of 75 female participants aged 18-54 years was recruited through female-focused social networks. Participants provided informed consent and underwent both Health Care Workers (HCW-collected) and self-collected sample collection using the Daye Diagnostic Tampon. Samples were stored in ThinPrep Vials (TP Vial) or Aptima® Multitest Swab Collection Kit (APTIMA®) solutions. HPV and STI testing were performed using TMA-based assay on the fully automated Panther® Platform. Acceptability was assessed through a questionnaire with Likert-scale responses.</p><p><strong>Results: </strong>The study involved 60 participants who completed the study (80% of recruited participants). The self-collected tampons showed sensitivity and specificity of 66.67% and 90.74% (when rinsed in TP Vial) and 83.33% and 85.42% (when rinsed in APTIMA®) for HPV detection, respectively. For bacterial vaginosis (BV) detection, the tampons exhibited sensitivity and specificity of 100.0% and 96.43% (TP Vial) and 88.89% and 98.04% (APTIMA), respectively. For detection of chlamydia and gonorrhoea (AC2), the sensitivity and specificity were 100.00% and 100.0% (TP Vial) and 100.00% and 98.31% (APTIMA), respectively. Participants expressed a preference for tampon self-collection over HCW-collected swabs (90%).</p><p><strong>Conclusion: </strong>Self-collected tampons demonstrated promising diagnostic accuracy to HCW-collected swabs for HPV and STI detection. The tampon self-collection method was well-accepted and preferred by participants, suggesting its potential as an alternative screening tool, particularly in low-resource settings. Further research with larger and more diverse populations is recommended to validate these findings and inform tampon-based self-collection programs for cervical cancer screening. Randomised controlled trials and comparisons with gold standard methods would enhance validation.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"141"},"PeriodicalIF":2.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of inflammatory states in response to psychological distress in breast cancer survivors and its relationship to subjective memory function complaints.","authors":"Chen Gan, Senbang Yao, Jingjing Zhao, Huangyuxin Shi, Jian Xu, Mingjun Zhang, Huaidong Cheng","doi":"10.1186/s12905-025-03674-7","DOIUrl":"10.1186/s12905-025-03674-7","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) survivors frequently endure psychological distress following chemotherapy, with subjective memory decline being a prevalent aspect of chemotherapy-related cognitive impairment (CRCI). This study aimed to assess the influence of psychological distress on subjective memory decline in BC survivors with CRCI and investigate potential underlying mechanisms.</p><p><strong>Methods: </strong>A total of 104 BC survivors who had completed chemotherapy were categorized based on the distress thermometer (DT) score into a no-psychological distress group (NPD group, n = 51) and a psychological distress group (PD group, n = 53). The groups were compared using the Mini-Mental State Examination (MMSE), the Prospective and Retrospective Memory (PM and RM) Questionnaire (PRMQ), cytokine levels (of interleukin-1β [IL-1β], tumor necrosis factor-alpha [TNF-α], and IL-4), and inflammatory markers (neutrophil-to- lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], monocyte count-to-lymphocyte ratio [MLR], granulocyte-to-lymphocyte ratio [GLR], and systemic immune-inflammation index [SII]). Mediation analysis was performed to explore whether cytokine and inflammatory marker levels mediate the effect of psychological distress on subjective memory function complaints.</p><p><strong>Results: </strong>The NPD group performed significantly better in the PD group both RM (z = -3.370, p = 0.001) and PM (z = -1.967, p = 0.049). The IL-1β levels were substantially higher in the PD group than in the NPD group (z = -2.920, p = 0.004). Similarly, NLR (z = -2.585, p = 0.010), GLR (z = -2.858, p = 0.004), and SII (z = -2.747, p = 0.006) were higher in the PD group. Mediation analysis revealed that IL-1β partially mediated the relationship between DT and RM (β = 0.019, p = 0.007), while SII fully mediated the relationship between DT and PM (β = 0.003, p = 0.017).</p><p><strong>Conclusion: </strong>BC survivors experiencing psychological distress exhibited worse subjective memory and elevated levels of IL-1β, NLR, GLR, and SII. These findings suggest that inflammation may be a cause of subjective memory function complaints in BC survivors with psychological distress.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"140"},"PeriodicalIF":2.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of factors associated with the occurrence of menstruation-related symptoms in Japanese women without exercise habits and female soccer players: a cross-sectional study.","authors":"Risa Mitsuhashi, Ryoko Mizushima, Hiroaki Natsui, Shuichi Machida, Yoshio Nakata","doi":"10.1186/s12905-025-03655-w","DOIUrl":"10.1186/s12905-025-03655-w","url":null,"abstract":"<p><strong>Purpose: </strong>The aims of this study were to identify factors associated with menstruation-related symptoms and compare them between female soccer players and women without exercise habits.</p><p><strong>Methods: </strong>This cross-sectional study was conducted between June and August 2022. Participants were healthy Japanese women aged 18-29 years, divided into two groups for comparison by exercise habits: women without exercise habits and female college soccer players. Participants responded to a self-administered questionnaire pertaining to their physical and menstrual characteristics, menstruation-related symptoms, and lifestyle habits. For menstruation-related symptoms, the Andersch and Milsom Scale was used to assess the severity of each of the 16 symptoms before and during menstruation. Lifestyle habits included stress, sleep, diet, and physical activity, which were assessed using Perceived Stress Scale, Japanese version of the Pittsburgh Sleep Quality Index, Food Frequency Questionnaire, and International Physical Activity Questionnaire, respectively. Data were analyzed using the t-test and multiple logistic regression analysis. All analyses were performed with a statistical significance of 5%.</p><p><strong>Results: </strong>A total of 428 women (192 without exercise habits; 236 soccer players) participated in the study, and 244 women (99 without exercise habits; 125 soccer players) were analyzed. For women without exercise habits, long menstrual days (OR = 5.627; 95% CI, 1.046-30.259) and high levels of stress (1.082; 1.011-1.157) were factors before menstruation, and stress (1.131; 1.045-1.225) was a factor during menstruation were significantly associated with severe menstruation-related symptoms. Contrastingly, for soccer players, high body mass index (BMI) (1.460; 1.080-1.973), late bedtime (0.288; 0.110-0.753) before menstruation, older age (1.662; 1.073-2.575), high BMI (1.468; 1.089-1.980), family history of menstruation-related symptoms (3.090; 1.179-8.098), late bedtime (0.358; 0.133-0.958), caffeine consumption ( 0.359; 0.139-0.930), and less frequent breakfast intake (0.807; 0.653-0.997) were significant factors. Additionally, the factors associated with the occurrence of menstruation-related symptoms differed according to the symptom type. The most frequently associated factor in women without exercise habits was stress (13 symptoms). In female soccer players, the most frequently associated factor was BMI (8 symptoms).</p><p><strong>Conclusion: </strong>Women presented different factors for menstruation-related symptoms depending on the presence or absence of exercise habits in their routine.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"139"},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social influences on Moroccan and Pakistani immigrant women's access and use of cervical cancer screening in Catalonia, Spain: a social network analysis.","authors":"Jone G Lurgain, Paula Peremiquel-Trillas, Hakima Ouaarab-Essadek, Khadija Mellouki, Andleed Sarif, Guy Harling","doi":"10.1186/s12905-025-03657-8","DOIUrl":"10.1186/s12905-025-03657-8","url":null,"abstract":"<p><strong>Background: </strong>Participation in cervical cancer (CC) screening programs is lower among immigrants compared to native women in many Western countries, in substantial due to lower knowledge and culturally influenced attitudes regarding self-care and prevention. Education and information programs alone have limited impact on individuals' attitudes and behaviours, but may be bolstered by social influence methods such as peer support.</p><p><strong>Methods: </strong>In this study, we combined self-reported quantitative structural social network data with qualitative narratives and graphs to describe the social context of 12 Moroccan and 10 Pakistani immigrant women living in Catalonia, Spain. We used a survey protocol and semi-structured interviews to explore how women's contacts influence their CC screening behaviours.</p><p><strong>Results: </strong>We identified strong gender and ethnic homophily in these women's social networks. Despite maintaining frequent remote contact with their family ties, their immigrant peers were more influential in providing health information and advice. Furthermore, the women's husbands played two conflicting roles as health promoters and as a barrier to the use of health prevention services.</p><p><strong>Conclusion: </strong>Our findings highlight the need to incorporate tailored social influence approaches in the design of behaviour change interventions. In this case, the use of peer-based programs to increase CC screening uptake among these two immigrant communities.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"136"},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling timing of sexual debut among women in Zimbabwe using a Geoadditive Discrete-Time survival approach.","authors":"Alphonce Bere, Innocent Maposa, Zvifadzo Matsena-Zingoni, Halima S Twabi, Jesca M Batidzirai, Geoffrey C Singini, Nobuhle Mchunu, Justine B Nasejje, Maureen Moyo-Chilufya, Oludoyinmola Ojifinni, Portia Nevhungoni, Alfred Musekiwa","doi":"10.1186/s12905-025-03590-w","DOIUrl":"10.1186/s12905-025-03590-w","url":null,"abstract":"<p><strong>Background: </strong>Early sexual debut has undesirable health consequences such as an increased risk of contracting sexually transmitted infections (STIs) including HIV, mental health problems, pregnancy-related complications and death including abortion-related deaths. Despite a global decline in adolescent birth rates, Zimbabwe continues to face a high prevalence of underage pregnancies, highlighting significant early sexual debut among Zimbabwean adolescents. This study examined the spatial variation and the demographic and socio-economic determinants of the timing of early sexual debut among Zimbabwean women.</p><p><strong>Methods: </strong>Data for 9,882 Zimbabwean women of reproductive age were drawn from the 2015 Zimbabwe Demographic and Health Survey (ZDHS). We defined early sexual debut as having first sexual intercourse before the 18 years of age. A fully Bayesian geoadditive discrete-time survival model was used. Adjustments for unequal sampling probabilities were done using the provided survey weights.</p><p><strong>Results: </strong>Our findings show that women with primary education (aOR = 0.62,95% Crl:0.47-0.81), secondary education (aOR = 0.25,95% Crl:0.19-0.33) and higher education (aOR = 0.06,95% Crl:0.04-0.09) had lower odds of early sexual debut than those with no education. In comparison to those with middle household wealth index, women with higher household wealth index (aOR = 0.83, 95% CrI: 0.71-0.98) had lower odds of early sexual initiation. On the other hand, women with lower household wealth index had higher likelihood of early sexual debut (aOR = 1.13, 95% CrI: 1.03-1.26) than those with middle household wealth index. The type of place of residence and birth year cohort did not have a significant association with the odds of early sexual debut. The hotspots of early sexual debut were in Matabeleland North and Matabeleland South provinces.</p><p><strong>Conclusion: </strong>To mitigate early sexual debut in Zimbabwe, targeted interventions are essential in Matabeleland North and Matabeleland South provinces as well as in the identified high-risk groups.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"137"},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early menopause is associated with higher disease activity independent of inflammation in postmenopausal-onset rheumatoid arthritis.","authors":"Zhi-Ming Ouyang, Yao-Wei Zou, Ye Lu, Jie Pan, Tao Wu, Pei-Wen Jia, Hu-Wei Zheng, Yun Su, Le-Feng Chen, Jian-Zi Lin, Kui-Min Yang, Pei-Yu Lin, Jin-Yuan Han, Jian-Da Ma, Lie Dai","doi":"10.1186/s12905-025-03670-x","DOIUrl":"10.1186/s12905-025-03670-x","url":null,"abstract":"<p><strong>Objective: </strong>Early menopause (EM, age ≤ 45 years) is associated with an increased risk of developing rheumatoid arthritis (RA). We aimed to investigate its impact on disease characteristics in RA patients.</p><p><strong>Methods: </strong>This cross-sectional study included natural post-menopausal RA patients from an observational RA cohort recruited between January 2015 and October 2023. Demographic characteristics and clinical data were collected. Patients were divided into EM and usual menopause (UM, menopause age > 45 years) groups. Patients-reported outcomes (PROs, included patient global assessment of disease activity [PtGA], pain visual analogue scale [VAS] and Stanford health assessment questionnaire disability index [HAQ-DI]), and PROs-associated indicators (included 28-joint tender joint count [TJC28] and provider global assessment of disease activity [PrGA]) were assessed.</p><p><strong>Results: </strong>Among 1427 female RA patients, 557 natural post-menopausal RA patients were enrolled. The peak menopause age was between 46 and 50 years, with RA incidence peaking 5 years post-menopause. Compared with UM patients, RA patients with natural EM (n = 98,17.6%) exhibited more serious disease, including worse PROs and PROs-associated indicators, as well as higher C-reactive protein (CRP, all P < 0.05). Among 344 (61.8%) patients with RA onset after menopause, EM patients (n = 62, 18.0%) were characterized with worse PROs and PROs-associated indicators than those with UM patients (all P < 0.05), but no difference in inflammatory makers. Multivariate linear regression showed that menopause age was independently and negatively associated with PROs, including PtGA (β = -0.872, 95% CI -1.619, -0.125), HAQ-DI (β = -0.646, 95% CI -1.059, -0.233) in RA patients especially in those onset after menopause (PtGA [β = -1.028, 95% CI -2.022, -0.034]; HAQ-DI [β = -0.916, 95% CI -1.461, -0.370]).</p><p><strong>Conclusion: </strong>Early menopause impacts on PROs independent of inflammation in patients with RA especially in those with postmenopausal-onset RA, which imply the importance of differentiation of non-inflammatory disease activity.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"138"},"PeriodicalIF":2.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}