BMC Women's Health最新文献

{"title":"Headache impact and quality of life following endometriosis surgery in women: a single-center observational study.","authors":"Filiz Değirmenci, Hamza Yildiz, Hakan Aytan, Mustafa Agah Teki̇ndal","doi":"10.1186/s12905-026-04720-8","DOIUrl":"10.1186/s12905-026-04720-8","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis and migraine are common chronic conditions in women of reproductive age that impair quality of life and frequently co-occur as comorbid conditions. Evidence regarding the effects of treatments targeting one of these conditions on the course of the other remains limited. In particular, the association between endometriosis surgery and headache burden and quality of life has not been sufficiently investigated. The aim of this study was to examine changes in headache burden and quality of life following endometriosis surgery in women with and without migraine.</p><p><strong>Methods: </strong>This single-center observational study included 88 women who had undergone endometriosis surgery between 3 months and 5 years prior to enrollment. Participants completed the Headache Impact Test-6 and the 12-Item Short Form Health Survey by retrospectively recalling their preoperative status, as prospective preoperative questionnaire records were not available, and reporting their current postoperative status. Changes over time, group differences, and time-by-group interactions were analyzed using mixed-design analysis of variance. Additional sensitivity analyses stratified by follow-up duration were performed to explore the potential influence of postoperative interval on change scores.</p><p><strong>Results: </strong>In both women with and without migraine, headache burden scores were lower and physical and mental quality of life component scores were higher at the postoperative assessment than in the retrospectively recalled preoperative period (p < 0.001). These differences were more pronounced among women with migraine.</p><p><strong>Conclusion: </strong>Women reported lower headache burden and better quality of life at the postoperative assessment than in the retrospectively recalled preoperative period in both groups, with greater changes observed among women with migraine. Given the retrospective assessment of preoperative status, prospective studies are needed to confirm these findings, optimize multidisciplinary management of endometriosis and migraine and to identify patient subgroups most likely to benefit from surgical intervention.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13688964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The uterine corpus flexion angle: a novel and objective sonographic marker for endometriosis severity and the quantification of the question mark sign.","authors":"Jing Chen, Shulin Zhong, Jiale Liang, Fang Liu, Lijuan Li, Shuyi Guo, Xiaoling Leng","doi":"10.1186/s12905-026-04695-6","DOIUrl":"10.1186/s12905-026-04695-6","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the correlation between the uterine corpus flexion angle (UCFA) and the severity of endometriosis, evaluate its clinical utility as a novel objective sonographic parameter, and provide an angular definition for the question mark sign.</p><p><strong>Methods: </strong>This mixed prospective-retrospective case-control study enrolled participants in a 1:1:1 ratio into three groups: the endometriosis group, the benign control group, and the normal control group. All participants underwent transvaginal ultrasonography (TVUS). The UCFA and uterine flexion angle (UFA) were independently measured in the standard midsagittal plane by two blinded sonographers. The subjective question mark sign was assessed by sonographers. In the endometriosis group, pelvic adhesions were graded intraoperatively using the revised American Society for Reproductive Medicine (rASRM) criteria. The correlation of the UCFA with the severity of endometriosis and the question mark sign was evaluated via Spearman's correlation, multivariate linear regression, and receiver operating characteristic curve analyses.</p><p><strong>Results: </strong>The UCFA progressively increased with higher rASRM stage (P < 0.001) and greater pelvic adhesion severity (P < 0.001). Multivariate linear regression analysis revealed that UCFA was primarily determined by pelvic adhesion score (β = 0.441), whereas UFA was predominantly influenced by baseline uterine position (β = 0.508). Subgroup analysis in 166 adenomyosis-free endometriosis patients confirmed that adhesion score remained the primary predictor of UCFA (β = 0.457). The optimal cutoff for the sonographic question mark sign was UCFA ≥ 220°, with an area under the curve (AUC) of 0.958. UCFA values were relatively stable in women without endometriosis, with a median of 179.0° in the benign control group and 178.0° in the normal group.</p><p><strong>Conclusions: </strong>The UCFA is a reliable objective sonographic marker for assessing the severity of endometriosis-related pelvic adhesions. The proposed criterion of UCFA ≥ 220° provides a validated, quantitative definition for the question mark sign, offering a practical tool for standardized ultrasonography assessment and preoperative surgical risk stratification.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus awareness and prevention practices among patients with Mayer-Rokitansky-Küster-Hauser syndrome after neovagina reconstruction: a cross-sectional study.","authors":"Yi Zhai, Jia Kang, Lan Zhu, Na Chen","doi":"10.1186/s12905-026-04704-8","DOIUrl":"10.1186/s12905-026-04704-8","url":null,"abstract":"<p><strong>Background: </strong>Patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) who undergo neovagina reconstruction remain at risk of Human papillomavirus infection (HPV), yet evidence regarding their awareness of HPV-related health risks and engagement in preventive behaviours is limited. This study aimed to assess HPV-related awareness, preventive practices and behavioural factors among Chinese patients with MRKH syndrome after neovagina reconstruction, and to describe HPV screening and vaccination uptake in this population.</p><p><strong>Methods: </strong>A cross-sectional questionnaire-based study was conducted at a tertiary referral hospital in Beijing, China. A total of 157 patients with MRKH syndrome who had undergone neovagina reconstruction completed validated questionnaires assessing HPV awareness, preventive practices and behavioural factors. In addition, outpatient clinical records of 1,756 patients with MRKH syndrome attending specialist care between 2012 and 2024 were retrospectively reviewed to obtain information on HPV testing and ThinPrep cytologic test (TCT) results where available. Descriptive statistical analyses were performed to summarise awareness levels, behavioural characteristics and preventive practice uptake.</p><p><strong>Results: </strong>Most participants demonstrated relatively high awareness of HPV-related health risks: 82.8% recognised their susceptibility to HPV infection and 75.8% expressed support for HPV vaccination. However, preventive practices remained limited. Only 11.5% of participants reported having undergone HPV screening, and 18.5% had received HPV vaccination, indicating a substantial gap between awareness and preventive action. Engagement with routine gynaecological follow-up was generally low. Among those who underwent HPV testing, HPV positivity was detected in a small proportion of patients, with observed rates ranging from 7.4% to 11.1%.</p><p><strong>Conclusions: </strong>Despite relatively high awareness of HPV and its prevention, Chinese patients with MRKH syndrome after neovagina reconstruction showed markedly low uptake of HPV vaccination and limited engagement with HPV testing. These findings highlight an unmet need for accessible HPV vaccination, neovaginal HPV risk education, and tailored sexual health education for this rare and underserved population. Further research is warranted to identify barriers to preventive care and to develop effective interventions to improve HPV prevention practices among women with MRKH syndrome.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic lipid indices and metabolic syndrome in polycystic ovary syndrome: a comparative cross-sectional study.","authors":"Sujata Baidya, Pratibha Kandel, Smrity Rajkarnikar, Sagar Parajuli, Apeksha Niraula, Eans Tara Tuladhar, Raju Kumar Dubey, Mithileshwer Raut, Aseem Bhattarai, Poonam Koirala, Vijay Kumar Sharma","doi":"10.1186/s12905-026-04734-2","DOIUrl":"10.1186/s12905-026-04734-2","url":null,"abstract":"<p><strong>Background: </strong>Polycystic Ovary Syndrome (PCOS) is one of the causes of infertility in females. It is also associated with hyperandrogenism and hyperinsulinemia. With these hormonal imbalances, there can be an equally important risk of cardiometabolic consequences as a result of altered atherogenic lipid indices and metabolic syndrome which has not been much explored in context of Nepal. The purpose of this study was to delve into different lipid profile parameters to calculate atherogenic lipid indices to identify the metabolic syndrome (MetS) and cardiovascular risk in PCOS.</p><p><strong>Methods: </strong>We enrolled 70 PCOS and 60 age-matched non-PCOS females visiting the Infertility Clinic at the Department of Obstetrics and Gynecology at Tribhuvan University Teaching Hospital. After written informed consent, anthropometric measurements as well as a blood samples were taken and biochemical analysis of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides were measured in Abbott ARCHITECT ci4100 autoanalyzer. Based on the examined variables, various formulas to assess atherogenic risk and metabolic syndrome [Castelli's risk index I & II (CRI-I, CRI-II), atherogenic coefficient (AC), atherogenic index of plasma (AIP), lipoprotein combined index (LCI), lipid accumulation product (LAP)] were applied. Descriptive and inferential analysis was carried in SPSS version 23.0. A p-value ≤ 0.05 was considered as significant.</p><p><strong>Results: </strong>The PCOS group had higher atherogenic lipid indices (CRI-I, CRI-II, AIP, AC, LCI and LAP) compared to their non-PCOS counterparts. The prevalence of metabolic syndrome (MetS) was also higher in the PCOS (81.4%, n = 57) compared to non-PCOS (30%, n = 18). The LAP score was found to be an efficient indicator of MetS in the PCOS patients with an AUC of 0.829 (p < 0.001), with the sensitivity and specificity of 80% and 94.5% respectively.</p><p><strong>Conclusions: </strong>Our study showed a higher frequency of MetS and cardiovascular risk in PCOS as determined by higher atherogenic lipid indices than non PCOS. LAP score was the most efficient indicator of MetS.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience of setting up midwife-led birth centers in Pakistan: a case study.","authors":"Razia Naveed, Zainab Khawaja, Adnan Ahmad Khan, Tazleem Ayaz, Hania Rehman, Saad Ibrahim Rasheed, Ayza Sadaf Khawaja, Kirsty Hughes, Oliva Bazirete, Sofia Castro Lopes, Sabera Turkmani, Andrea Nove, Mandy Forrester, Caroline S E Homer","doi":"10.1186/s12905-026-04703-9","DOIUrl":"10.1186/s12905-026-04703-9","url":null,"abstract":"<p><strong>Introduction: </strong>Midwife-led birth centers (MLBCs) exist in Pakistan in various financial and operational capacities. Some operate independently, providing maternity services for a small user fee. Others operate through public-private partnerships involving collaboration between the government and NGOs. Currently, there is insufficient evidence available on the experiences of community midwives as maternal health care providers in MLBCs. There is also a lack of evidence about how midwives can operate in the private sector, although MLBCs are becoming more widespread nationwide. The study aimed to explore how MLBCs operate, to identify innovative approaches to improving women-centred care services.</p><p><strong>Methods: </strong>In-depth interviews were conducted with 6 stakeholders working in senior or leadership roles and 20 MLBC clients receiving maternity care services. Four Focus Group Discussions (FGDs) were organized with 25 individuals currently working as healthcare workers in MLBCs including midwives and nurses.</p><p><strong>Results: </strong>Five key themes were identified to describe MLBCs in Pakistan, especially women's experiences. The themes were (i) Having competent midwives, (ii) Providing comprehensive and accessible services that women need and want, (iii) Providing quality of care, (iv) Being disconnected from the healthcare system and (vi) Managing the cost.</p><p><strong>Conclusion: </strong>This study contributes to the understanding of MLBCs in Pakistan, their functioning, and providing quality, accessible, and affordable maternity care. Midwives provide humane and client-centered care at much lower prices, making their services accessible to a larger audience. The gap for women who want affordable high-quality care but cannot afford the premium fees of the private sector can be filled by establishing MLBCs and integrating them into the national health system. The policymakers and stakeholders should prioritize actionable steps in securing sustainable finance, continued medical, and integration of MLBCs into the larger public health system to harness the full potential of MLBCs in delivering high-quality, safe, and dignified maternity care to all, regardless of socioeconomic status.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13688969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-management strategies for menstrual cycle symptoms: a systematic review.","authors":"Rebecca Tarpey, Laura Keaver, Lisa Ryan, Kerry McGawley, Charles R Pedlar, Ken van Someren","doi":"10.1186/s12905-026-04717-3","DOIUrl":"https://doi.org/10.1186/s12905-026-04717-3","url":null,"abstract":"<p><strong>Purpose: </strong>Menstrual cycle symptoms, such as discomfort, fatigue, and mood swings, are prevalent among women and can significantly diminish quality of life. Many women employ non-clinical, self-management strategies to mitigate symptoms, yet the supporting evidence for these strategies is equivocal. This systematic review sought to identify, evaluate and synthesise existing evidence from randomised controlled trials (RCTs) for non-clinical, self-management strategies for menstrual cycle symptoms.</p><p><strong>Methods: </strong>A systematic literature search was performed in PubMed, Scopus, Web of Science, and Cochrane Library in March 2025 and updated in December 2025. The review adhered to PRISMA principles. Eligible studies comprised double- and triple-blinded RCTs published from 2000 onwards that examined non-clinical, self-management strategies including physical activity, nutrition, heat treatment, sleep, stress management, education, and over-the-counter medications for alleviating menstrual cycle symptoms in females aged 18 years and older. The JBI Critical Appraisal Checklist for RCTs was utilised for quality assessment.</p><p><strong>Results: </strong>Of the 13,208 screened records, 39 were included in the final synthesis, comprising 42 treatment interventions and 3,806 participants. This provided categories of physical activity strategies (n = 5), nutritional strategies (n = 26), other self-management strategies (n = 7), and combined strategies (n = 4). Physical activity, especially yoga, consistently showed improvements in menstrual discomfort, exhaustion, and mood. The most researched strategies were nutritional, including vitamin and mineral supplementation, and demonstrated varied yet predominantly positive results. Some of the other self-management strategies, including low light therapy, listening to music and drawing, also reduced total PMS scores. Some of the combined strategies, investigating two or more strategies in combination, reduced menstrual cycle symptoms and menstrual pain intensity. Methodological shortcomings were prevalent, including small sample sizes and inconsistent outcome measurements.</p><p><strong>Conclusions: </strong>Data from 39 RCTs indicate that strategies including physical activity, nutrition, other self-management strategies and combined strategies may effectively alleviate menstrual cycle symptoms. There are limitations in the evidence base due to limited research and methodological inconsistencies, and publication bias may have skewed the results to being predominantly positive. Future research ought to evaluate common strategies that are yet to be investigated using blinded RCTs, and the long-term efficacy of existing self-management strategies.</p><p><strong>Trial registration: </strong>CRD420250612937.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum androstenedione levels are associated with dysmenorrhea and pain severity among women without endometriosis: an exploratory cross-sectional study.","authors":"Tingting Li, Sihui Yu, Peipei Shi, Sheng Yin, Jiarong Zhang","doi":"10.1186/s12905-026-04725-3","DOIUrl":"10.1186/s12905-026-04725-3","url":null,"abstract":"<p><strong>Background: </strong>Dysmenorrhea is a common gynecological condition with heterogeneous etiologies. Endometriosis is an important condition associated with dysmenorrhea, but the serum steroid and reproductive hormone profiles related to dysmenorrhea, and whether these associations differ by endometriosis status, remain unclear. This study aimed to investigate the associations of serum hormone profiles with dysmenorrhea and pain severity.</p><p><strong>Methods: </strong>This exploratory cross-sectional study was conducted from October 2022 to January 2024 at Zhongshan Hospital, Fudan University. A total of 139 premenopausal participants were classified into dysmenorrhea (n = 73) and non-dysmenorrhea (n = 66) groups and further stratified by endometriosis status. Serum steroid and reproductive hormones were measured using liquid chromatography-tandem mass spectrometry and immunoassays. Group comparisons were performed according to data distribution, and false discovery rate (FDR) adjustment was applied for multiple hormone comparisons. Multivariable logistic regression was used to evaluate the association between androstenedione (A4) and dysmenorrhea.</p><p><strong>Results: </strong>In the overall cohort, women with dysmenorrhea showed higher A4 levels and a higher luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, although these differences did not remain significant after FDR adjustment. After stratification by endometriosis status, these differences were mainly observed among women without endometriosis. In this subgroup, A4 levels were significantly higher in women with dysmenorrhea than in those without dysmenorrhea (0.85 ± 0.36 vs. 0.65 ± 0.28 ng/mL, P = 0.004; FDR-adjusted P = 0.024), as was the LH/FSH ratio (2.11 ± 1.47 vs. 1.44 ± 1.02, P = 0.013; FDR-adjusted P = 0.047). Among women without endometriosis, A4 was modestly correlated with visual analogue scale score (Spearman r = 0.285, P = 0.006) and remained associated with dysmenorrhea after multivariable adjustment (odds ratio = 8.07, 95% confidence interval: 1.60-40.65, P = 0.011). A4 and the LH/FSH ratio showed modest discrimination, with area under the curve values of 0.660 and 0.655, respectively.</p><p><strong>Conclusions: </strong>Serum A4 levels were associated with dysmenorrhea and pain severity, particularly among women without endometriosis. The LH/FSH ratio showed a weaker supportive association. These exploratory findings support further investigation of androgen-related endocrine profiles in dysmenorrhea without endometriosis, but A4 and the LH/FSH ratio showed limited standalone discriminatory value.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR2400079587, Retrospectively registered on 2024-01-08.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13681882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infertility-related stress and attachment styles as predictors of fertility readiness in women undergoing infertility treatment.","authors":"Rukiye Sulu Dursun, Mehtap Duran, Ebru Gozuyesil, Sefa Arlier","doi":"10.1186/s12905-026-04729-z","DOIUrl":"10.1186/s12905-026-04729-z","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify the predictors of fertility readiness, specifically examining the roles of infertility-related stress and attachment styles in women undergoing infertility treatment.</p><p><strong>Methods: </strong>This study used a descriptive and cross-sectional design. It was conducted with 316 women who sought treatment at the Assisted Reproductive Treatment Center at Adana City Hospital, located in Adana Province, Turkey, between April 2024 and September 2024. Data were collected through the \"Personal Information Form,\" the \"Fertility Problem Stress Scale,\" the \"Relationship Scales Questionnaire,\" and the \"Fertility Preparedness Scale for Women Receiving Fertility Treatment\".</p><p><strong>Results: </strong>The participants' Fertility Preparedness Scale total mean score was 89.88 ± 13.34. A negative, low-level, and significant relationship was found between fertility preparedness and personal stress domain score (p < 0.05). A negative and significant relationship was also found between the prepared body and brain and the social stress domain score (p < 0.05). Regression analysis, including all stress domain and attachment subscale scores, explained 4.6% of the variance in readiness for fertility (R²adjusted = 0.046, p < 0.001); within this model, increased personal stress and increased preoccupied attachment emerged as the only statistically significant individual predictors (p < 0.05).</p><p><strong>Conclusion: </strong>This study suggested that women may feel more ready for fertility as their personal stress decreases and their preoccupied attachment levels decline.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lived experiences of reproductive-aged women with polycystic ovary syndrome: a qualitative study.","authors":"Kaitlyn J Ward, A K Benzley, K L King Stone, E S Wardell, J A Hughes, B M Magnusson","doi":"10.1186/s12905-026-04681-y","DOIUrl":"10.1186/s12905-026-04681-y","url":null,"abstract":"<p><strong>Background: </strong>PCOS is a complex health condition that affects up to 20% females of reproductive age worldwide, and approximately 5 million U.S. females of reproductive aged females. Despite the prevalence of the condition, research on the lived experiences of women with PCOS is limited, particularly in the United States.</p><p><strong>Methods: </strong>This study employed a phenomenological qualitative design to explore the lived experiences of individuals diagnosed with PCOS. We conducted semi-structured interviews via web conferencing with 39 females 18-45 years of age, residing in the U.S. with PCOS. Transcribed interviews were analyzed using the Framework Method.</p><p><strong>Results: </strong>We identified ten primary themes in the data 1) Critical shift point, 2) Education, 3) Future Experience, 4) Gaslighting (or blame), 5) Medical Experience, 6) Present Emotional Experience, 7) Social Impacts, 8) Treatment, 9) Well-documented Physical Symptoms, and 10) Not Well-Documented Symptoms and an additional 37 sub-themes. Overall, the experiences of living with PCOS were generally negative, especially in relation to gaslighting or blame, medical experience, symptoms - both well documented and not well documented, present emotional experience, social impacts, and treatment. Additionally, many participants reported a critical shift point that led to them seeking a diagnosis and treatment for their condition, and a lack of education in relation to PCOS.</p><p><strong>Conclusions: </strong>Women with PCOS experience a wide-ranging physical, mental, and relational impacts. Awareness of the impact of PCOS is needed to reduce gaps in provider knowledge, social disconnect, fear of judgment, and mental health concerns. Further research is needed to understand the impact of PCOS on the lived experience of post-menopausal women, and to develop improved education for both providers and those in the social circle of women with PCOS.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13682020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory evaluation of a CEUS-derived substitution for solid-component measurement in the ADNEX model.","authors":"Manli Wu, Ying Chen, Shuangyu Wu, Ruili Wang, Xiaotao Meng, Hong Wen, Rui Zhang, Liang Mu, Li Xiao, Tingting Liu, Sijia Chen, Zeping Huang, Junlin Zhong, Yatong Chen, Ying Wang, Man Zhang, Licong Huang, Jingjing Liu, Xiaofeng Sun, Xinling Zhang","doi":"10.1186/s12905-026-04700-y","DOIUrl":"10.1186/s12905-026-04700-y","url":null,"abstract":"<p><strong>Background: </strong>Although the Assessment of Different Neoplasias in the adnexa (ADNEX) model has been widely validated, there remains challenges in differentiating true solid components from benign mimics. We aimed to evaluate the feasibility and value of substituting conventional ultrasound-derived solid component size with CEUS-derived measurements in the ADNEX model for adnexal lesions discrimination.</p><p><strong>Methods: </strong>This multicenter prospective study recruited consecutive patients with suspected adnexal lesions with solid components detected at ultrasound between January 2022 and June 2024. All patients underwent preoperative CEUS examination. Pathological results serve as the reference standard. Each adnexal lesion was evaluated using ADNEX, a CEUS-based modified ADNEX score (CEUS-derived substitution for solid-component measurement without updating model coefficients) and Ovarian-Adnexal Reporting and Data System (O-RADS) Ultrasound (US) score.</p><p><strong>Results: </strong>A total of 204 patients (median age, 47.0 years [IQR: 33.0-56.0 years]) with 204 lesions were included. The area under the receiver operating characteristic curve (AUROC) for CEUS-based modified ADNEX was 0.906 (95% CI: 0.867-0.944), which was superior to that of ADNEX (AUROC:0.865; 95% CI, 0.814-0.916; P = 0.019) and O-RADS US (AUROC: 0.783; 95% CI, 0.726 -0.840; P < 0.001) in classifying adnexal lesions with solid components. CEUS-based modified ADNEX demonstrated greater specificity (0.664) compared to ADNEX (0.283; P < 0.001) and O-RADS US (0.221; P < 0.001).</p><p><strong>Conclusions: </strong>CEUS-derived modification for solid-component measurement in the ADNEX model showed potential improvements in the diagnostic specificity and clinical benefit compared with the original ADNEX framework in the classification of adnexal lesions with solid components.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"26 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}