BMC Women's Health最新文献

{"title":"Aggressive primary uterine non-Hodgkin's lymphoma presenting as acute kidney injury: a case report.","authors":"Rawan Al-Deeb, Ram Attaf, Yaman Saiouf, Baraa Mouzi, Assef Dayyoub","doi":"10.1186/s12905-025-03775-3","DOIUrl":"10.1186/s12905-025-03775-3","url":null,"abstract":"<p><strong>Introduction: </strong>Primary malignant lymphoma of the cervix is an extremely rare condition, accounting for only 0.008% of all cervical tumors and 2% of female extranodal lymphomas. The most common histological subtype is diffuse large B-cell lymphoma. This malignancy is often asymptomatic in its early stages, but advanced cases may include systemic symptoms, pelvic discomfort, and vaginal bleeding. Diagnosis is challenging due to its nonspecific clinical presentation and similarity to other gynecological conditions. Imaging and immunohistochemistry play essential roles in diagnosis and staging. Treatment typically involves chemotherapy, with the standard CHOP regimen for Non-Hodgkin's lymphoma being the main treatment in most cases. To the best of our knowledge, this is the first case in the literature to describe acute kidney injury associated with the already rare entity of primary female genital tract lymphoma.</p><p><strong>Case presentation: </strong>A 66-year-old multiparous woman presented with severe headache, nausea, vomiting, and dizziness lasting three days, alongside systemic symptoms such as weight loss, lethargy, and night sweats. Imaging indicated bilateral hydronephrosis, ascites, and an enlarged uterus with a suspected tumor. Biopsy confirmed diffuse large B-cell lymphoma with immunohistochemical positivity for CD20 and negative CD3. The patient was classified as stage IV according to the Ann Arbor system. Initial treatment included diuretics, hemodialysis, and chemotherapy with a dose-reduced CHOP regimen due to atrial fibrillation and reduced cardiac ejection fraction. Despite initial improvements, the patient developed tumor lysis syndrome and meningeal infiltration. Her condition deteriorated after the second chemotherapy cycle, culminating in neutropenic fever, massive hemorrhage, and ultimately death.</p><p><strong>Conclusion: </strong>Our case highlights the diverse manifestations of the disease, including acute kidney injury secondary to bilateral hydronephrosis, a previously unreported complication. Early recognition is essential for optimal management. While chemotherapy remains the mainstay of treatment, the lack of standardized protocols underscores the need for further research. This case emphasizes the unpredictable nature of primary female genital tract lymphomas and their potential to cause systemic complications.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"244"},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of high intensity focused ultrasound in the treatment of uterine fibroids in overweight/obese women.","authors":"Lijing Wu, Liying Zhong, Qingyan Zheng, Lingna Huang, Fengning Lin, Zhiwei Chen, Chengying Lian","doi":"10.1186/s12905-025-03797-x","DOIUrl":"10.1186/s12905-025-03797-x","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy and safety of High-Intensity Focused Ultrasound (HIFU) in the treatment of uterine fibroids in overweight/obese women.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 155 overweight/obese women with uterine fibroids treated at our hospital between January 2022 and January 2024. Among them, 75 patients underwent HIFU treatment (observation group), while 80 patients received conventional laparoscopic myomectomy (control group). Perioperative indicators, symptom improvement (assessed by the Symptom Severity Score, SSS), health-related quality of life (HRQL score), complications, and recurrence rates at 1-year post-treatment were compared between the two groups.</p><p><strong>Results: </strong>All procedures were successfully completed in both groups. No significant differences were observed in baseline characteristics such as age, BMI, number of fibroids, maximum fibroid diameter, and hemoglobin levels between the two groups (P > 0.05). At 6 months and 1 year post-treatment, the observation group showed significantly better SSS scores (12.61 ± 1.22 vs. 15.89 ± 1.21; 10.40 ± 1.27 vs. 12.03 ± 1.33) and HRQL scores (89.35 ± 1.90 vs. 84.69 ± 1.24; 94.19 ± 1.16 vs. 91.69 ± 1.32) compared to the control group (P < 0.05). The total complication rate in the observation group was significantly lower than that in the control group (9.33% vs. 21.3%, χ² = 4.34, P = 0.04). No recurrence or fibroid enlargement was observed in the observation group at 1-year follow-up.</p><p><strong>Conclusion: </strong>HIFU is an effective and safe treatment for uterine fibroids in overweight/obese women, offering advantages such as minimal invasiveness, fewer complications, and faster recovery. It represents a superior minimally invasive option for this patient population.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"243"},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical and breast cancer screening outcomes among Métis people in Alberta, Canada.","authors":"Michelle L Aktary, Reagan Bartel, Ashton James, June Kima, Amanda Andrew, Angeline Letendre, Chinmoy Rahul, Bonnie Chiang, James Newsome, Huiming Yang, Karen A Kopciuk","doi":"10.1186/s12905-025-03799-9","DOIUrl":"10.1186/s12905-025-03799-9","url":null,"abstract":"<p><strong>Background: </strong>Breast and cervical cancer rates among Métis people in Canada are higher than non-Indigenous people but the impact of cancer screening is uncertain. This study investigated breast and cervical cancer screening participation, retention, and follow-up care among age-eligible Métis people living in Alberta compared to their non-Métis counterparts from 2006 to 2022.</p><p><strong>Methods: </strong>Data from the Otipemisiwak Métis Government of the Métis Nation within Alberta (MNA) Identification Registry were linked to the Alberta Breast and Cervical Cancer Screening Programs, and the Alberta Cancer Registry for the years 2006 to 2022. Relative and absolute differences in rates, percentages, and means/medians were calculated between Métis and non-Métis people, including age-eligible females, people with a cervix, and people who have taken gender-affirming hormones for five or more years. Trends were assessed using suitable Joinpoint models.</p><p><strong>Results: </strong>Métis and non-Métis people had similar breast and cervical cancer screening participation and retention rates. However, the time between abnormal cancer screening results and follow-up tests was longer for Métis people compared to non-Métis people. Métis people had higher proportions of abnormal cytology test results, and more were diagnosed with advanced-stage cervical cancer (p = 0.06) than non-Métis people. There were no differences in breast cancer stage at diagnosis.</p><p><strong>Conclusion: </strong>Ongoing collaboration between the MNA and Screening Programs will build on evidence from the current study to support cancer screening programs and services for all Métis people in Alberta.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"246"},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young women's perspectives on a user-friendly self-sampling intervention to improve the diagnosis of sexually transmitted infections in underserved communities in KwaZulu-Natal, South Africa.","authors":"Ziningi Nobuhle Jaya, Witness Mapanga, Tivani Phosa Mashamba-Thompson","doi":"10.1186/s12905-025-03684-5","DOIUrl":"10.1186/s12905-025-03684-5","url":null,"abstract":"<p><strong>Introduction: </strong>Young women are disproportionately affected by sexually transmitted infections (STIs), especially in the KwaZulu-Natal province of South Africa thus the need for availability and accessibility to STI healthcare services. The main objective of this study was to collaborate with young women, using a nominal group technique (NGT), to identify barriers to existing STI healthcare services to ultimately identify strategies to inform attributes for a discrete choice experiment (DCE) towards developing a user-friendly self-sampling intervention for STI diagnosis in young women. The NGT was underpinned by the theoretical domains framework to identify and analyse factors that influence healthcare seeking behaviour.</p><p><strong>Methods: </strong>Eight young women, aged 18-24 years, were purposively selected from primary healthcare clinics in underserved communities. An NGT was conducted comprising the following steps: silent generation where individuals considered and recorded their responses to a question; round-robin sharing, recording and discussion of individual responses; followed by ranking of contributions. Thematic analysis was used to analyse data.</p><p><strong>Results: </strong>The following barriers to accessing STI healthcare services were identified: the clinics were too far from home; young women feared judgement by clinic staff; young women feared being told to inform their partners; clinic hours clashed with school hours and other personal commitments; and young women did not know enough about the signs and symptoms of STIs. The following strategies to improve access to STI healthcare services were suggested: campaigns to promote self-sampling; self-sampling kits should be available free of charge; an online system to assess symptoms and register to receive self-sampling kits via delivery or collection to accommodate people with disabilities.</p><p><strong>Conclusion: </strong>The strategies identified informed the attributes for the DCE which is aimed towards the development of a user-friendly self-sampling intervention for STI diagnosis in young women in KwaZulu-Natal.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"245"},"PeriodicalIF":2.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The preferences of breast cancer patients regarding a digital social care platform.","authors":"Sima Rafiei, Peigham Heidarpoor, Saber Souri, Zahra Nejatifar, Mohammad Amerzadeh","doi":"10.1186/s12905-025-03792-2","DOIUrl":"10.1186/s12905-025-03792-2","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is a multifaceted condition affecting women globally, with patients often facing emotional, psychological, and social challenges. This study explored breast cancer patients' preferences for features of a digital social care platform.</p><p><strong>Methods: </strong>A cross-sectional study using Conjoint Analysis (CA), grounded in economic utility theory, was conducted. A Discrete Choice Experiment (DCE) questionnaire was administered to 158 breast cancer patients at a university hospital in Iran between November 2023 and January 2024. Data were analysed using ordered logistic regression in Stata 13.</p><p><strong>Results: </strong>All platform attributes significantly influenced preferences (P ≤ 0.05). Emotional support had the highest impact (β = 1.132), followed by informational (β = 0.973) and esteem support (β = 0.864). Instructional videos increased the likelihood of choosing a digital platform 2.45 times compared to text-based messages (P < 0.001). Personalized online support was 1.42 times more preferred than generic supportive messages (P < 0.001). Mindfulness affirmations were 1.14 times more preferred than inspirational messages (P < 0.001).</p><p><strong>Conclusion: </strong>Digital tools that prioritize emotional, informational, and esteem support-especially through personalized online support and instructional videos can improve patient engagement and acceptability. These findings support the patient-centred design of digital social care platforms to enhance quality of life for breast cancer patients.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"240"},"PeriodicalIF":2.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of negative expectations and emotions in primary dysmenorrhea: insights from a case-control study.","authors":"Verena Thomann, Nadya Gomaa, Marina Stang, Susanne A Funke, Karin Meissner","doi":"10.1186/s12905-025-03784-2","DOIUrl":"10.1186/s12905-025-03784-2","url":null,"abstract":"<p><strong>Background: </strong>Primary dysmenorrhea, characterized by painful menstruation, significantly impacts the quality of life for women worldwide. Negative expectations and associated emotions are known to trigger nocebo effects and may also influence cyclic menstrual pain. In this study, we investigated the role of pain expectations and negative anticipatory emotions as potential contributing factors to hyperalgesia in women with severe menstrual pain, compared to women with absent or mild menstrual pain.</p><p><strong>Methods: </strong>We conducted a prospective case-control study in women with severe menstrual pain due to primary dysmenorrhea, comparing them with age-matched women with absent or mild menstrual pain. Data collection included the Depression, Anxiety, and Stress Scale (DASS-21) at baseline, as well as daily numeric rating scales (NRS) to evaluate pain expectations, anticipatory negative emotions, and daily stress during the 10 days preceding menstruation. Saliva samples were collected to evaluate the Cortisol Awakening Response (CAR) before menstruation, and pain was assessed during the first 3 days of menstruation.</p><p><strong>Results: </strong>Women with high menstrual pain reported significantly higher DASS-21 anxiety levels compared to low-pain controls, although still within the normal range (median [IQR], 3 [2; 5] vs. 1 [1; 3], p <.05). In the 10 days preceding menstruation, the high-pain group expected significantly higher maximum pain levels than controls (median [IQR], 8 [7.3; 8.5] vs. 2.1 [1; 3.3], p <.001), which aligned with their actual experiences of maximum pain during menstruation (6.5 [4.8; 7.7] vs. 1.2 [0.7; 2.3], p <.001). Anticipatory stress (2.1 [0.9; 4.2] vs. 0.2 [0; 0.9], p <.001), anticipatory anxiety (0.7 [0.0; 2.3] vs. 0 [0; 0], p <.001), anticipatory worry (1.3 [0.4; 2.6] vs. 0.1 [0; 0.3], p <.001), and anticipatory anger (0.7 [0; 1.5] vs. 0 [0; 0.2], p <.01) were also significantly higher in the high-pain group in the 10 days before menstruation. The CAR showed no significant differences between groups in the days before menstruation. Correlational analyses revealed multiple positive associations between expected pain levels, anticipatory negative emotions, and subsequently perceived levels of menstrual pain in both groups (all p-values < 0.05).</p><p><strong>Conclusions: </strong>This pioneering study supports the hypothesis that cognitive-emotional factors such as heightened pain anticipation and negative emotions intensify menstrual pain severity in primary dysmenorrhea, although causal conclusions cannot be drawn from this observational study. Strategies aimed at optimizing expectations could play a significant role in managing primary dysmenorrhea.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"241"},"PeriodicalIF":2.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violence experienced by women, their mental health status, and determinants in favelas under the pandemic COVID-19 in Brazil.","authors":"Mônica Chiodi Toscano de Campos, Rander Junior Rosa, Leticia Perticarrara Ferezin, Thaıs Zamboni Berra, Heriederson Savio Dias Moura, Ariela Fehr Tartaro, Yan Mathias Alves, Reginaldo Bazon Vaz Tavares, Natacha Martins Ribeiro, Juliana Soares Tenório de Araújo, Fernanda Bruzadelli Paulino da Costa, Regina Célia Fiorati, Maria Del Pilar Serrano-Gallardo, Ricardo Alexandre Arcêncio","doi":"10.1186/s12905-025-03793-1","DOIUrl":"10.1186/s12905-025-03793-1","url":null,"abstract":"<p><strong>Background: </strong>Women in situations of vulnerability experience situations of violence aggravated by their social condition and which generate mental health problems, and these conditions have been further exacerbated by the COVID-19 pandemic.</p><p><strong>Objective: </strong>This study aims to scrutinize the frequency of violence against women and their mental health status within favelas during the COVID-19 pandemic in Brazil, exploring how the pandemic may have impacted these issues and identifying factors that contribute to these experiences.</p><p><strong>Methods: </strong>It is a cross-sectional and quantitative study in which data were obtained through the application of a questionnaire adapted and validated for the Brazilian context. The sample consisted of Brazilian women over 18 years old, who lived lived in favelas in the capital cities of Brazilian states. Sampling was carried out using a sequential approach, including participants as they were located and agreed to take part in the study. Descriptive analyses (absolute and relative frequency) were carried out to characterize the profile of the people who answered the questionnaire and logistic regression to identify the factors associated with mental health status and violence against women.</p><p><strong>Results: </strong>A total of 766 women living in favelas answered the questionnaire. The majority identified themselves as black/brown (75.8%), single, separated, or widowed (51.7%), had completed high school (43.1%), worked informally (47.1%) and did not receive government assistance (57.3%). Black/brown women (OR: 1,05; IC95% 4,55 - 2,53) who were married (OR: 2,45; IC95% 1,18 - 5,19) and exposed to drug trafficking (OR: 3,23; IC95% 1,36 - 7,97) were more likely to experience conjugal violence during the pandemic. In addition, women with informal employment (OR: 3,26; IC95%: 1,24 - 9,55) and complete higher education (OR: 4,47; IC95%: 1,68 - 1,21), were more likely to consider their mental health as precarious during the pandemic period.</p><p><strong>Conclusions: </strong>The pandemic has exacerbated the social vulnerability of these women, highlighting the need to incorporate a gender perspective into the formulation of public policies during health crises such as the COVID-19 pandemic.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"242"},"PeriodicalIF":2.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of shared decision-making on the conflict and regret in menopause symptoms management: an interventional study.","authors":"Leyla Mortazavi Ghehi, Mohammad Asghari Jafarabadi, Sevil Hakimi, Roghaiyeh Nourizadeh, Esmat Mehrabi, Mahdie Arab Bafrani","doi":"10.1186/s12905-025-03774-4","DOIUrl":"10.1186/s12905-025-03774-4","url":null,"abstract":"<p><strong>Introduction: </strong>Menopausal women often face challenges in choosing appropriate interventions to mitigate distressing menopause symptoms, primarily due to concerns about treatment suitability. Therefore, the present study aimed to assess the effect of shared decision-making (SDM) on conflict and regret in menopause symptoms management.</p><p><strong>Method: </strong>This interventional study was conducted on 44 menopausal women aged ≥ 45 years in Tabriz, Iran, from September 2020 to January 2021. Subjects were randomly assigned to the intervention (n = 22), which received SDM-based counseling along with a decision aid (DA) booklet, and control (n = 22) groups. The data were collected using a socio-demographic and obstetric characteristics checklist, awareness of the menopause symptoms management strategies, decisional conflict, and regret. The intergroup differences were compared employing an independent t-test and ANCOVA.</p><p><strong>Results: </strong>The mean score of decision conflict [Mean difference (MD): -2.07, 95% CI: -29.65 to -11.92, P = 0.001] and decision regret [MD: -1.25, 95% CI: -1.64 to 0.64, P = 0.03] significantly reduced in the intervention group compared to the control group after the intervention. Additionally, a statistically significant increase in the mean score of women's awareness was observed in the intervention group compared to the control group following the intervention [(Hormone Therapy: MD: 3.38, 95% CI: 1.01 to 5.57, P = 0.006) (Natural Products: MD: 2.44, 95% CI: 0.93 to 3.94, P = 0.002)].</p><p><strong>Conclusion: </strong>The results indicated the effect of SDM-based counseling on improving women's awareness of the menopause symptoms management strategies and reducing the decisional conflict and regret.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"239"},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does adenomyosis influence tumor characteristics and survival in endometrioid-type endometrial cancer??","authors":"Gorkem Ulger, Sevki Goksun Gokulu, Kasim Akay, Hamza Yildiz, Ali Yildizbakan, Tolgay Tuyan Ilhan, Hakan Aytan","doi":"10.1186/s12905-025-03786-0","DOIUrl":"10.1186/s12905-025-03786-0","url":null,"abstract":"<p><strong>Background: </strong>The coexistence of adenomyosis and cancer of the endometrium has attracted heightened scrutiny, leading to inquiries regarding their possible interactions and clinical ramifications. This study sought to assess the influence of adenomyosis on tumor features and survival outcomes in patients with endometrioid-type endometrial carcinoma.</p><p><strong>Materials and methods: </strong>A retrospective cohort analysis was performed on 422 patients who underwent surgical intervention for endometrioid-type endometrial carcinoma. The cohort was categorized into two groups according to the presence or absence of adenomyosis. Clinical and pathological data were gathered and evaluated to compare tumor features and survival outcomes between the two cohorts.</p><p><strong>Results: </strong>Adenomyosis was present in 144 (34.1%) patients. Patients in the adenomyosis group demonstrated significantly higher gravidity and parity compared to those without adenomyosis. Lymphovascular space invasion was detected in 8.3% of the adenomyosis group compared to 17.6% in the non-adenomyosis group (a 53% reduction, p = 0.010). Similarly, rates of myometrial invasion (81.3% vs. 65.5%, p = 0.001), cervical stromal invasion (9.0% vs. 14.1%, p = 0.005), and lymph node metastasis (4.2% vs. 14.4%, p = 0.001) were significantly lower in patients with adenomyosis. The five-year overall survival rate was 90.8% in the adenomyosis group and 87.1% in the non-adenomyosis group, although this difference was not statistically significant (p = 0.689).</p><p><strong>Conclusions: </strong>This study demonstrates that adenomyosis is associated with a significant reduction in aggressive tumor characteristics such as myometrial invasion, lymphovascular space involvement, and lymph node metastasis in patients with endometrioid-type endometrial cancer. These findings emphasize that adenomyosis may be a potential protective factor in endometrial cancer prognosis and should be considered in clinical risk assessment. Prospective studies with larger cohorts are needed to confirm the long-term effects of adenomyosis on survival.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"237"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on early marriages and pregnancy health in the South-Eastern region of Türkiye.","authors":"Eda Yakit Ak, Mehmet Ali Şen, Özden Tandoğan","doi":"10.1186/s12905-025-03788-y","DOIUrl":"10.1186/s12905-025-03788-y","url":null,"abstract":"<p><strong>Background: </strong>The study was conducted to determine the attitudes of women who were married at an early age in their region towards such marriages and their experiences related to pregnancies.</p><p><strong>Methods: </strong>The data for the study were collected through the implementation of a semi-structured interview form, and the \"deductive content analysis technique\" was used to analyze the data. The study was conducted using a phenomenological design from qualitative research methods.</p><p><strong>Results: </strong>Four main themes were obtained in the study. Theme 1 The process leading to early marriages: Women are married off with the decision of the family and the support of their relatives, and mostly without having met each other. Theme 2 The course of marriage: The first day of marriage is considered frightening, and the responsibilities of the house are burdened on a girl child. Theme 3 Pregnancies: Women report health problems due to the fact that they are still children themselves, and their bodies are not suitable for a pregnancy. Theme 4: Childcare: Women experience problems related to their inexperience and financial problems in caring for children, and at the same time, they do not want their children's future to be like theirs. Theme 5: Cultural process leading to early marriages: Women state that early marriage is a traditional and cultural problem and that this situation is considered normal and should be.</p><p><strong>Conclusion: </strong>The factors that influence the decision to enter into early marriage include family decisions and cultural norms. In addition to the challenges associated with marriage, women express a desire for their children to have access to more advantageous educational opportunities.</p>","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"236"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}