Brain Imaging and Behavior最新文献_第7页

Analysis of the relationship between brain activation and clinical indicators in amnestic mild cognitive impairment. 遗忘型轻度认知障碍患者脑活动与临床指标的关系分析。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1007/s11682-025-01004-x

Hye-Min Heo, Kyeong-Hwa Lee, Kyeong-Hwa Heo, Ye-Chae Hwang, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko, Hyug-Gi Kim, Geon-Ho Jahng, Jung-Mi Park

{"title":"Analysis of the relationship between brain activation and clinical indicators in amnestic mild cognitive impairment.","authors":"Hye-Min Heo, Kyeong-Hwa Lee, Kyeong-Hwa Heo, Ye-Chae Hwang, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko, Hyug-Gi Kim, Geon-Ho Jahng, Jung-Mi Park","doi":"10.1007/s11682-025-01004-x","DOIUrl":"10.1007/s11682-025-01004-x","url":null,"abstract":"This study aimed to identify the clinical symptoms and indicators that might affect brain activity in patients with amnestic mild cognitive impairment. Thirty-one patients with amnestic mild cognitive impairment were recruited between March 2022 and June 2023. Functional magnetic resonance imaging, neuropsychological tests, and blood tests were also performed. Brain activation was analyzed using voxel- and region-of-interest-based methods. The correlation between the functional magnetic resonance imaging results and the acquired clinical indicators was determined using Pearson's correlation analysis. In the face-name association memory task, activation of the hippocampus and parahippocampal gyrus was found to be negatively correlated with the Short Form of the Geriatric Depression Scale score. Precentral gyrus and precuneus activation positively correlated with the percentage of correct answers in the one-back task. In the working memory N-back task, activation of the superior parietal lobule was positively correlated with the percentage of correct answers in the zero-back task. Age and activation in the hippocampus and parahippocampal gyrus are positively correlated. Depression, age, and sex significantly affected brain activity. Activation of the precentral gyrus, superior parietal lobule, and precuneus influences N-back task competency. Overall, this study is the first to analyze the correlation between brain function and clinical indicators of amnestic mild cognitive impairment.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"732-745"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients. 重度抑郁症和童年情感忽视的多基因风险对年轻抑郁症患者皮质血流复杂性的影响。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.1007/s11682-025-00983-1

Lijun Kang, Qian Gong, Wei Wang, Zhaowen Nie, Lihua Yao, Dan Xiang, Ning Tu, Hongyan Feng, Huiling Wang, Gaohua Wang, Lihong Bu, Zhongchun Liu

{"title":"Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients.","authors":"Lijun Kang, Qian Gong, Wei Wang, Zhaowen Nie, Lihua Yao, Dan Xiang, Ning Tu, Hongyan Feng, Huiling Wang, Gaohua Wang, Lihong Bu, Zhongchun Liu","doi":"10.1007/s11682-025-00983-1","DOIUrl":"10.1007/s11682-025-00983-1","url":null,"abstract":"Major depressive disorder (MDD) exhibits a moderate degree of heritability and shares common influences with early adverse life events, as well as being associated with inconsistent changes in cerebral blood flow (CBF). Here, we investigated whether MDD polygenic risk score (PRS) and emotional neglect influences alterations in CBF. We collected blood and ASL from MDD patients. Emotional neglect (EN) assessment was performed using the Childhood Trauma Questionnaire. We calculated PRS for MDD based the MDD GWAS result in Asian populations. Subsequently, we examined the interaction between PRS for MDD and EN on CBF. Finally, 174 participated in statistical analysis. After adjusting for confounding factors, there was a significant main effect of PRS on left dorsolateral superior frontal gyrus, while the main effect of EN was not significantly (P < 0.001, GRF corrected). And significant interactive effect was found between PRS of MDD and EN on precuneus CBF (P < 0.001, GRF corrected). In MDD, high polygenic risk independently influenced changes in left dorsolateral superior frontal gyrus CBF, while EN plays a role in individuals with a higher genetic risk for MDD. Our study indicates the need to consider the combined effects of genetic risk and early adverse events on alterations in brain structure in the occurrence of MDD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"713-720"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity. 步态冻结的自动性降低与皮质-小脑连通性升高有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI: 10.1007/s11682-025-00996-w

Daniel H Lench, Aaron Embry, Niloufar Malakouti, Nathan DeTurk, Gonzalo J Revuelta

{"title":"Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity.","authors":"Daniel H Lench, Aaron Embry, Niloufar Malakouti, Nathan DeTurk, Gonzalo J Revuelta","doi":"10.1007/s11682-025-00996-w","DOIUrl":"10.1007/s11682-025-00996-w","url":null,"abstract":"Freezing of gait (FOG) in individuals with Parkinson's Disease is associated with a loss of gait automaticity. This loss of automaticity is demonstrated by worsening gait performance while dual tasking. Functional connectivity between the cerebellar vermis and cortex have previously been associated with spatiotemporal measures of gait in PD. The objective of this study was to determine whether this corticocerebellar connectivity is associated with gait automaticity as measured by dual task interference in PD FOG. 55 participants with PD were recruited (38 FOG, 17 non-FOG controls) to undergo a resting-state functional magnetic resonance imaging scan. Gait automaticity was quantified using spatiotemporal metrics from single and dual task time up and go trials. FOG participants demonstrated shorter step length and gait velocity compared to non-FOG PD controls. A trend toward greater dual task interference of step length in the FOG group was found. Using a seed-based connectivity approach we observed that FOG participants have greater vermis connectivity than non-FOG PD participants to several cortical regions including the superior parietal lobe, supplemental motor area, precentral gyrus and posterior cingulate (voxel threshold p < 0.01, cluster FWE corrected p < 0.05). Meanwhile, vermis connectivity to the occipital cortex was reduced in FOG participants relative to non-FOG controls. Dual task interference of step length among the FOG group correlated with the degree of vermis connectivity to the sensorimotor cortex and superior parietal cortex (voxel threshold p < 0.01, cluster FWE corrected p < 0.05). We conclude that increased corticocerebellar connectivity may be associated with loss of gait automaticity in individuals with PD FOG.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"637-646"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients. 白质完整性介导血浆尿酸水平对ALS患者认知功能的影响。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-03-29 DOI: 10.1007/s11682-025-00991-1

Jiahui Tang, Yali Zhao, Yu Chen, Yuan Yang, Zhenxiang Gong, Zehui Li, Min Zhang, Jing Zhang

{"title":"White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients.","authors":"Jiahui Tang, Yali Zhao, Yu Chen, Yuan Yang, Zhenxiang Gong, Zehui Li, Min Zhang, Jing Zhang","doi":"10.1007/s11682-025-00991-1","DOIUrl":"10.1007/s11682-025-00991-1","url":null,"abstract":"Objective: To investigate the association between plasma uric acid levels and white matter microstructural alterations in amyotrophic lateral sclerosis (ALS) patients and to explore the potential mediating role of white matter microstructural alterations in the protective effect of plasma uric acid on cognitive function in ALS patients.Methods: 73 right-handed ALS patients were recruited for this study. Plasma uric acid levels were measured, diffusion tensor imaging scans were performed to assess white matter integrity, and cognition was evaluated using the Edinburgh Cognitive and Behavioral Screen. The relationships among plasma uric acid, white matter integrity, and cognitive function were examined through multivariate linear regression analysis. Additionally, mediation analysis was performed to investigate whether white matter integrity mediated the relationship between uric acid levels and cognitive function.Results: The findings revealed a positive correlation between plasma uric acid levels and extensive preservation of white matter microstructure in various regions, including the fornix, cerebellar, internal capsule, frontotemporal and frontooccipital lobe bundles among ALS patients. Mediation analysis indicated that fractional anisotropy in the hippocampal portion of the cingulum fully mediated the effects of plasma uric acid levels on executive function in ALS patients.Interpretation: Our results suggested that elevated plasma uric acid may preserve the integrity of white matter microstructure in ALS patients. Furthermore, we have identified evidence supporting the mediating influence of the hippocampal portion of the cingulum in linking plasma uric acid levels to cognitive function among ALS patients.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"678-689"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the neural network correlates of apathy, disinhibition, and executive dysfunction in active-duty United States Special Operations Forces. 调查美国现役特种作战部队中冷漠、解除抑制和执行功能障碍的神经网络相关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI: 10.1007/s11682-025-00980-4

Natalie Gilmore, Isabella R McKinney, Chieh-En J Tseng, Douglas N Greve, Chiara Maffei, Brian C Healy, Nicole R Zürcher, Jacob M Hooker, Samantha L Tromly, Daniel P Perl, Kristen Dams-O'Connor, Christine L Mac Donald, Brian L Edlow, Yelena G Bodien

{"title":"Investigating the neural network correlates of apathy, disinhibition, and executive dysfunction in active-duty United States Special Operations Forces.","authors":"Natalie Gilmore, Isabella R McKinney, Chieh-En J Tseng, Douglas N Greve, Chiara Maffei, Brian C Healy, Nicole R Zürcher, Jacob M Hooker, Samantha L Tromly, Daniel P Perl, Kristen Dams-O'Connor, Christine L Mac Donald, Brian L Edlow, Yelena G Bodien","doi":"10.1007/s11682-025-00980-4","DOIUrl":"10.1007/s11682-025-00980-4","url":null,"abstract":"United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 29 male active-duty SOF with mean (SD) 17(4) years of service, we tested whether self-reported symptoms of apathy, disinhibition, and executive dysfunction measured by the Frontal Systems Behavior Scale, were related to functional magnetic resonance imaging and positron emission tomography biomarkers (translocator protein and tau) of the limbic, salience, and executive control networks. Higher disinhibition was associated with lower functional connectivity and higher tau signal within the salience network, though both associations diminished with age. These findings provide the basis for future multimodal studies to elucidate the relationship between neurobehavioral symptoms and neuroimaging biomarkers in the context of repeated blast exposure.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"627-636"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing morphological fingerprints in perinatal brains using quasi-conformal mapping: occurrence and neurodevelopmental implications. 利用准适形映射揭示围产期大脑的形态指纹：发生和神经发育意义。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-03-27 DOI: 10.1007/s11682-025-00998-8

Ying Wang, Boyang Wang, Dalin Zhu, Weihao Zheng, Yucen Sheng

{"title":"Revealing morphological fingerprints in perinatal brains using quasi-conformal mapping: occurrence and neurodevelopmental implications.","authors":"Ying Wang, Boyang Wang, Dalin Zhu, Weihao Zheng, Yucen Sheng","doi":"10.1007/s11682-025-00998-8","DOIUrl":"10.1007/s11682-025-00998-8","url":null,"abstract":"The morphological fingerprint in the brain is capable of identifying the uniqueness of an individual. However, whether such individual patterns are present in perinatal brains, and which morphological attributes or cortical regions better characterize the individual differences of neonates remain unclear. In this study, we proposed a deep learning framework that projected three-dimensional spherical meshes of three morphological features (i.e., cortical thickness, mean curvature, and sulcal depth) onto two-dimensional planes through quasi-conformal mapping, and employed the ResNet18 and contrastive learning for individual identification. We used the cross-sectional structural MRI data of 461 infants, incorporating with data augmentation, to train the model and fine-tuned the parameters based on 41 infants who had longitudinal scans. The model was validated on a fold of 20 longitudinal scanned infant data, and remarkable Top1 and Top5 accuracies of 85.90% and 92.20% were achieved, respectively. The sensorimotor and visual cortices were recognized as the most contributive regions in individual identification. Moreover, morphological fingerprints successfully predicted the long-term development of cognition and behavior. Furthermore, the folding morphology demonstrated greater discriminative capability than the cortical thickness. These findings provided evidence for the emergence of morphological fingerprints in the brain at the beginning of the third trimester, which may hold promising implications for understanding the formation of individual uniqueness, and predicting long-term neurodevelopmental risks in the brain during early development.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"666-677"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life adversity and white matter microstructural organization-a systematic review. 早期生活逆境与白质微观结构组织的系统回顾。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-04-25 DOI: 10.1007/s11682-025-01007-8

Orla Mitchell, Darren W Roddy, Michael Connaughton

{"title":"Early life adversity and white matter microstructural organization-a systematic review.","authors":"Orla Mitchell, Darren W Roddy, Michael Connaughton","doi":"10.1007/s11682-025-01007-8","DOIUrl":"10.1007/s11682-025-01007-8","url":null,"abstract":"Early life adversity, defined as exposure to stressful events during childhood, is a significant risk factor for the development of psychiatric disorders. Diffusion tensor imaging studies employing tract-based spatial statistics have shown microstructural abnormalities in white matter among individuals exposed to early life adversity; however, robust conclusions are yet to be drawn. This systematic review synthesizes findings of previous tract-based spatial statistics studies to identify the white matter alterations in adult brains exposed to early life adversity, in papers with methodological consistency. The literature search (April 2024) was conducted to identify tract-based spatial statistics studies that compared diffusion metrics between adults exposed to early life adversity and adults not. Embase, Pubmed, and PsycInfo were searched, retrieving 2458 articles. Following deduplication, 1739 titles and/or abstracts were screened. 1699 articles were excluded, and 40 full texts were reviewed. Seven articles, reporting on 764 subjects, met the inclusion criteria and were included in the narrative synthesis. Compared to controls, adults exposed to early life adversity showed lower fractional anisotropy values in white matter tracts of the limbic and visual processing systems, specifically the anterior thalamic radiation, inferior longitudinal fasciculus, corona radiata, uncinate fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle. This systematic review highlights that early life adversity may underlie emotional dysregulation and contribute to an increased risk of psychopathology in later life and explores the potential neurobiological mechanisms that underpin these structural changes. Understanding these associations is crucial for developing targeted interventions aimed at mitigating the long-term impact of early life adversity.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"785-799"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of affective forecasting in individuals with high trait anxiety: evidence from resting-state functional connectivity. 高特质焦虑个体情感预测的神经关联：来自静息状态功能连接的证据。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1007/s11682-025-01002-z

An Xie, Peng Liu, Qin Zhou, Tao Chen, Dao-Qun Ding, Rui-Ting Zhang

{"title":"Neural correlates of affective forecasting in individuals with high trait anxiety: evidence from resting-state functional connectivity.","authors":"An Xie, Peng Liu, Qin Zhou, Tao Chen, Dao-Qun Ding, Rui-Ting Zhang","doi":"10.1007/s11682-025-01002-z","DOIUrl":"10.1007/s11682-025-01002-z","url":null,"abstract":"Previous literature has indicated that individuals with high trait anxiety have negative bias in forecasting future emotions, but the neural mechanisms underlying this remain unclear. Individuals with high trait anxiety (HTA; n = 38) and individuals with low trait anxiety (LTA; n = 38) were recruited. All participants completed the Social Affective Forecasting task and underwent resting-state fMRI scanning. Compared with the LTA group, the HTA group anticipated lower levels of arousal for future positive events but showed comparable performance for anticipated valence for future positive events. Moreover, the HTA group demonstrated intact performance in reporting anticipated valence and anticipated arousal for future negative events. In addition, the HTA group demonstrated increased functional connectivity between the left ventromedial prefrontal cortex (vmPFC) and left lingual gyrus relative to the LTA group. Besides, the HTA group also showed increased functional connectivity between the dorsal anterior insula and right posterior cingulate cortex compared to the LTA group. No significant associations were found between the altered functional connectivity and affective forecasting performance. Increased functional connectivity observed in the HTA group suggested that HTA individuals may devote more efforts when anticipating future events, to maintain intact in anticipating valence for future events.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"721-731"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the social gene expression network and social brain network: a resting-state functional magnetic resonance imaging study. 社会基因表达网络与社会脑网络的比较：静息状态功能磁共振成像研究。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-04-01 Epub Date: 2025-03-06 DOI: 10.1007/s11682-025-00993-z

Yi-Jing Zhang, Hao-Yun Zhao, Peng Li, Xiao Lin, Lin Lu

{"title":"Comparison of the social gene expression network and social brain network: a resting-state functional magnetic resonance imaging study.","authors":"Yi-Jing Zhang, Hao-Yun Zhao, Peng Li, Xiao Lin, Lin Lu","doi":"10.1007/s11682-025-00993-z","DOIUrl":"10.1007/s11682-025-00993-z","url":null,"abstract":"Numerous previous studies have classified brain regions related to social processing into the \"social brain\" regions. Recent genetic studies showed that gene expression has a crucial effect on both brain functions and behavioral social performance. However, studies still lack a clear understanding of the organization of the social gene expression (SocGene) network. This study aimed to distinguish the difference between the SocGene network and the social brain network (SBN) and further explored their deficits in schizophrenia (SCZ) patients. The SocGene network was constructed by generating the gene expression maps of six social neuropeptide receptors from the Allen Human Brain Atlas. Then, we recruited a general population sample of 37 participants and a clinical sample including 26 SCZ and 25 Healthy controls (HCs) successively to construct the resting-state SocGene and SBN at the individual level. The integration (global efficiency, GE) and segregation (local efficiency, LE) of these brain networks were calculated using the graphic analysis. Results showed that the GE and LE of the SocGene network were significantly higher than those of the SBN in both two cohorts. The SCZ patients showed significantly diminished LE of the two brain networks compared to HCs, especially in the SocGene network. These findings implied that the SocGene network strengthened the integration and segregation compared to the SBN. SCZ patients mainly exhibited deficits in the segregation of these two brain networks. The current findings provide a new perspective on combining genetic expression and brain function in understanding the psychopathology of social functioning.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"534-542"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional abnormalities of white and gray matter in youths with conduct problems. 行为问题青少年脑白质和灰质的局部异常。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-04-01 Epub Date: 2025-03-17 DOI: 10.1007/s11682-025-00973-3

Man Dong, Xiaodong Cheng, Yage Li, Shanling Ji, Hao Yu, Liangliang Ping, Chuanxin Liu, Cong Zhou

{"title":"Regional abnormalities of white and gray matter in youths with conduct problems.","authors":"Man Dong, Xiaodong Cheng, Yage Li, Shanling Ji, Hao Yu, Liangliang Ping, Chuanxin Liu, Cong Zhou","doi":"10.1007/s11682-025-00973-3","DOIUrl":"10.1007/s11682-025-00973-3","url":null,"abstract":"Conduct problems (CP) encompass a wide array of behavioral difficulties in youths, including aggression, defiance, and rule-breaking, resulting in interpersonal conflicts. CP comprises various psychiatric conditions, constituting a significant public health burden. This study performed a whole-brain coordinate-based meta-analysis (CBMA) that synthesized findings from diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and surface-based morphometry (SBM) studies to investigate consistent structural brain abnormalities in children and adolescents with CP. A total of 35 studies were eventually included. Altered white matter integrity in the right lenticular nucleus and the right inferior longitudinal fasciculus (ILF) were observed. Gray matter volume (GMV) alterations included increased volume in the right superior frontal gyrus, as well as reduced volume in the right supramarginal gyrus and left amygdala. Cortical thickness reductions were detected in the left precentral gyrus and right superior frontal gyrus. These findings underscored the intricate neurobiological basis of CP, and the meta-regression analysis revealed age-related variations in structural brain alterations, further highlighting the need for early and personalized interventions. This comprehensive study advanced our understanding of the neural underpinnings of CP, and future research and interdisciplinary collaboration to translate our findings into meaningful interventions for individuals with CP should be further explored.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"578-593"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0