White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients.

IF 2.4 3区医学 Q2 NEUROIMAGING

Brain Imaging and Behavior Pub Date : 2025-03-29 DOI:10.1007/s11682-025-00991-1

Jiahui Tang, Yali Zhao, Yu Chen, Yuan Yang, Zhenxiang Gong, Zehui Li, Min Zhang, Jing Zhang

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引用次数: 0

Abstract

Objective: To investigate the association between plasma uric acid levels and white matter microstructural alterations in amyotrophic lateral sclerosis (ALS) patients and to explore the potential mediating role of white matter microstructural alterations in the protective effect of plasma uric acid on cognitive function in ALS patients.

Methods: 73 right-handed ALS patients were recruited for this study. Plasma uric acid levels were measured, diffusion tensor imaging scans were performed to assess white matter integrity, and cognition was evaluated using the Edinburgh Cognitive and Behavioral Screen. The relationships among plasma uric acid, white matter integrity, and cognitive function were examined through multivariate linear regression analysis. Additionally, mediation analysis was performed to investigate whether white matter integrity mediated the relationship between uric acid levels and cognitive function.

Results: The findings revealed a positive correlation between plasma uric acid levels and extensive preservation of white matter microstructure in various regions, including the fornix, cerebellar, internal capsule, frontotemporal and frontooccipital lobe bundles among ALS patients. Mediation analysis indicated that fractional anisotropy in the hippocampal portion of the cingulum fully mediated the effects of plasma uric acid levels on executive function in ALS patients.

Interpretation: Our results suggested that elevated plasma uric acid may preserve the integrity of white matter microstructure in ALS patients. Furthermore, we have identified evidence supporting the mediating influence of the hippocampal portion of the cingulum in linking plasma uric acid levels to cognitive function among ALS patients.

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白质完整性介导血浆尿酸水平对ALS患者认知功能的影响。

目的：探讨肌萎缩性侧索硬化症（ALS）患者血浆尿酸水平与白质微结构改变的关系，并探讨白质微结构改变在血浆尿酸对ALS患者认知功能保护作用中的潜在介导作用。方法：招募73例右撇子ALS患者进行研究。测量血浆尿酸水平，进行弥散张量成像扫描以评估白质完整性，并使用爱丁堡认知和行为筛查评估认知能力。通过多元线性回归分析检验血浆尿酸、白质完整性与认知功能之间的关系。此外，还进行了中介分析，以调查白质完整性是否介导尿酸水平与认知功能之间的关系。结果：血浆尿酸水平与ALS患者穹窿、小脑、内囊、额颞叶和额枕叶束等各区域白质微结构的广泛保存呈正相关。中介分析表明，扣带海马部分的分数各向异性完全介导了血浆尿酸水平对ALS患者执行功能的影响。解释：我们的研究结果表明，血浆尿酸升高可能保持ALS患者白质微结构的完整性。此外，我们已经发现证据支持扣带海马部分在将血浆尿酸水平与ALS患者的认知功能联系起来方面的介导作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Imaging and Behavior 医学-神经成像

CiteScore

7.20

自引率

0.00%

发文量

154

审稿时长

3 months

期刊介绍： Brain Imaging and Behavior is a bi-monthly, peer-reviewed journal, that publishes clinically relevant research using neuroimaging approaches to enhance our understanding of disorders of higher brain function. The journal is targeted at clinicians and researchers in fields concerned with human brain-behavior relationships, such as neuropsychology, psychiatry, neurology, neurosurgery, rehabilitation, and cognitive neuroscience.