White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients.

IF 2.4 3区医学 Q2 NEUROIMAGING

Brain Imaging and Behavior Pub Date : 2025-03-29 DOI:10.1007/s11682-025-00991-1

Jiahui Tang, Yali Zhao, Yu Chen, Yuan Yang, Zhenxiang Gong, Zehui Li, Min Zhang, Jing Zhang

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引用次数: 0

Abstract

Objective: To investigate the association between plasma uric acid levels and white matter microstructural alterations in amyotrophic lateral sclerosis (ALS) patients and to explore the potential mediating role of white matter microstructural alterations in the protective effect of plasma uric acid on cognitive function in ALS patients.

Methods: 73 right-handed ALS patients were recruited for this study. Plasma uric acid levels were measured, diffusion tensor imaging scans were performed to assess white matter integrity, and cognition was evaluated using the Edinburgh Cognitive and Behavioral Screen. The relationships among plasma uric acid, white matter integrity, and cognitive function were examined through multivariate linear regression analysis. Additionally, mediation analysis was performed to investigate whether white matter integrity mediated the relationship between uric acid levels and cognitive function.

Results: The findings revealed a positive correlation between plasma uric acid levels and extensive preservation of white matter microstructure in various regions, including the fornix, cerebellar, internal capsule, frontotemporal and frontooccipital lobe bundles among ALS patients. Mediation analysis indicated that fractional anisotropy in the hippocampal portion of the cingulum fully mediated the effects of plasma uric acid levels on executive function in ALS patients.

Interpretation: Our results suggested that elevated plasma uric acid may preserve the integrity of white matter microstructure in ALS patients. Furthermore, we have identified evidence supporting the mediating influence of the hippocampal portion of the cingulum in linking plasma uric acid levels to cognitive function among ALS patients.

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来源期刊

Brain Imaging and Behavior 医学-神经成像

CiteScore

7.20

自引率

0.00%

发文量

154

审稿时长

3 months

期刊介绍： Brain Imaging and Behavior is a bi-monthly, peer-reviewed journal, that publishes clinically relevant research using neuroimaging approaches to enhance our understanding of disorders of higher brain function. The journal is targeted at clinicians and researchers in fields concerned with human brain-behavior relationships, such as neuropsychology, psychiatry, neurology, neurosurgery, rehabilitation, and cognitive neuroscience.