Brain Imaging and Behavior最新文献

Mild cognitive impairment is associated with effect of uremic metabolites on gray matter structural changes in end-stage kidney disease. 轻度认知障碍与尿毒症代谢物对终末期肾病灰质结构改变的影响有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-08 DOI: 10.1007/s11682-025-01003-y

Huijie Yuan, Zhaoyao Luo, Jing Yang, Shaohui Ma, Peng Li, Xinyi Wang, Hang Su, Ronghua He, Junya Mu, Yuchen Zhang

{"title":"Mild cognitive impairment is associated with effect of uremic metabolites on gray matter structural changes in end-stage kidney disease.","authors":"Huijie Yuan, Zhaoyao Luo, Jing Yang, Shaohui Ma, Peng Li, Xinyi Wang, Hang Su, Ronghua He, Junya Mu, Yuchen Zhang","doi":"10.1007/s11682-025-01003-y","DOIUrl":"10.1007/s11682-025-01003-y","url":null,"abstract":"To investigate the grey matter volume (GMV) changes and uremic metabolites in end-stage kidney disease (ESKD) patients with mild cognitive impairment (MCI) (ESKD-MCI) and further examine the classification and diagnostic efficacy of these features for ESKD-MCI patients. A total of 65 patients with ESKD, including 34 ESKD-MCI and 31 with non-cognitive impairment (ESKD-NCI), and 55 health controls (HCs) were enrolled. All participants underwent brain structural magnetic resonance imaging (MRI) scanning and Montreal cognitive assessment test. Clinical characteristics and GMV differences among these three groups were analyzed. In addition, mediation analysis was performed to determine the mediating effect of GMV changes on the association between clinical risk factors and MCI. Finally, support vector machine were employed to examine the classification and diagnostic efficacy of GMV changes and clinical features for MCI. Both patient groups exhibited widespread structural brain injury compared with the HCs. Moreover, compared with ESKD-NCI, ESKD-MCI patients demonstrated reduced GMV specifically in the left middle temporal gyrus and inferior temporal gyrus. Notably, these GMV changes completely mediates the effect of serum phosphorus levels on MCI. Furthermore, imaging features rather than serum phosphorus levels had good classification and diagnostic efficacy for ESKD-MCI. Our findings underscore the significance of the left temporal gyrus as a pivotal brain region in ESKD-MCI patients, fully mediating the link between uremic metabolite and MCI. GMV alterations presents a promising avenue for effectively detecting MCI in individuals with ESKD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"835-845"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired interhemispheric synchrony in Parkinson's disease patients with progressive cognitive impairment. 伴有进行性认知障碍的帕金森病患者的半球间同步功能受损。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-05 DOI: 10.1007/s11682-025-01009-6

Xinhui Wang, Peng Liu, Qiurong Yu, Naying He, Yu Liu, Youmin Zhang, Fuhua Yan

{"title":"Impaired interhemispheric synchrony in Parkinson's disease patients with progressive cognitive impairment.","authors":"Xinhui Wang, Peng Liu, Qiurong Yu, Naying He, Yu Liu, Youmin Zhang, Fuhua Yan","doi":"10.1007/s11682-025-01009-6","DOIUrl":"10.1007/s11682-025-01009-6","url":null,"abstract":"Cognitive decline is a common non-motor symptom of Parkinson's disease (PD), which can occur at any stage of the disease. However, the neural mechanisms of PD cognitive changes remain unclear. It has been reported that hemispheric asymmetry is associated with cognitive impairment. Thus, we aimed to explore the underlying mechanisms of PD subgroups with different degrees of cognitive progression by assessing functional interhemispheric coordination and their relations with cognition. Fifty-four PD patients including 29 stable cognitive performance (sPD) patients, 25 progressive cognitive impairment (pPD) patients, and 18 healthy controls (HC) were recruited in this study. All subjects underwent T1-weighted, resting-state functional magnetic resonance imaging scanning, and neuropsychological evaluations. Voxel-mirrored Homotopic Connectivity (VMHC) and voxel-based morphometry analysis were applied to detect functional interhemispheric coordination. Fisher z transformed VMHC (z-VMHC) value lower in the middle temporal gyrus (MTG), middle occipital gyrus (MOG), and superior temporal gyrus (STG) in the pPD group when compared to the sPD group. However, we did not detect the difference in gray matter volume among the three groups. Furthermore, the z-VMHC value of MTG and MOG was positively correlated with the Montreal Cognitive Assessment (MoCA) score of the follow-up. Therefore, z-VMHC values within the MTG, MOG, and STG appeared to be potential neuroimaging features to distinguish pPD patients from sPD groups. These findings may underlie the neural mechanisms of cognitive performance in PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"811-820"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered resting-state functional connectivity in male individuals with methamphetamine use disorder at two different withdrawal periods: spotlight on the paraventricular thalamic nucleus. 两个不同戒断期男性甲基苯丙胺使用障碍患者静息状态功能连通性的改变：聚焦于室旁丘脑核。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1007/s11682-025-01008-7

Yifan Li, Shubao Chen, Shucai Huang, Zhe Du, Qiuping Huang, Shuhong Lin, Xinwen Wen, Chenhan Wang, Tieqiao Liu, Hongxian Shen, Xuyi Wang, Kai Yuan

{"title":"Altered resting-state functional connectivity in male individuals with methamphetamine use disorder at two different withdrawal periods: spotlight on the paraventricular thalamic nucleus.","authors":"Yifan Li, Shubao Chen, Shucai Huang, Zhe Du, Qiuping Huang, Shuhong Lin, Xinwen Wen, Chenhan Wang, Tieqiao Liu, Hongxian Shen, Xuyi Wang, Kai Yuan","doi":"10.1007/s11682-025-01008-7","DOIUrl":"10.1007/s11682-025-01008-7","url":null,"abstract":"Preclinical research highlights the paraventricular thalamic nucleus as important in various stages of substance use disorder. However, there is limited research on it in relation to methamphetamine, especially regarding its functional changes after long-term abstinence. This study aims to understand the alterations in functional connectivity of the paraventricular thalamic nucleus in methamphetamine abstainers and its correlation with drug craving at two different withdrawal periods. A total of 49 subjects were allocated to the short-term withdrawal group, 44 to the long-term withdrawal group, and 42 to the healthy control group, all of whom are male and adult. Craving scores were assessed using a visual analogue scale. Functional connectivity was evaluated through resting-state functional MRI, which reflects the correlation between connectivity in different brain regions. Significant differences in functional connectivity between the paraventricular thalamic nucleus and the left caudate nucleus were observed across the three groups. The healthy control group exhibited the strongest connectivity, followed by the long-term withdrawal group, while the short-term withdrawal group demonstrated the weakest connectivity. Within the short-term withdrawal group, functional connectivity of the paraventricular thalamic nucleus with both the left parahippocampal gyrus (r = -0.45, p = 0.001) and the left inferior temporal gyrus (r = -0.43, p = 0.002) was significantly correlated with craving scores. This study confirms abnormalities in the paraventricular thalamic nucleus among male methamphetamine abstainers, emphasizes its potential role in regulating methamphetamine use disorder and craving mechanisms, and offers insights into long-term changes in brain function after abstinence.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"801-810"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter microstructural and cognitive function changes in bipolar depression patients with suicidal ideation. 自杀意念双相抑郁症患者脑白质微结构及认知功能改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-31 DOI: 10.1007/s11682-025-01019-4

Junfan Liang, Rui Fan, Xinyin Guo, Hua Liu, Xuehua Li, Jixiang Yuan, Kezhi Liu, Xuemei Liang, Bo Xiang

{"title":"White matter microstructural and cognitive function changes in bipolar depression patients with suicidal ideation.","authors":"Junfan Liang, Rui Fan, Xinyin Guo, Hua Liu, Xuehua Li, Jixiang Yuan, Kezhi Liu, Xuemei Liang, Bo Xiang","doi":"10.1007/s11682-025-01019-4","DOIUrl":"10.1007/s11682-025-01019-4","url":null,"abstract":"The pathophysiological mechanisms underlying suicidal ideation and decreased cognitive function in bipolar depression remain elusive. This study sought to elucidate the potential neuroanatomical basis of these phenomena using diffusion tensor imaging (DTI). 40 patients experiencing bipolar depressive episodes were enrolled, comprising 20 individuals with suicidal ideation (BDSI +), 20 without suicidal ideation (BDSI-), and 20 healthy controls (HCs), all of whom underwent DTI scanning. Clinical assessments primarily utilized the Beck Scale for Suicide Ideation (BSSI) and the Trail Making Test (TMT). Differences in fractional anisotropy (FA) values among the groups were compared using Tract-Based Spatial Statistics (TBSS). The identified differential brain regions were designated as regions of interest (ROIs), and covariance analysis was employed to compare the FA values among the three groups. Partial correlation analyses were conducted between the FA values in the ROIs and clinical symptoms. Differences in brain regions identified through TBSS were observed in the genu of the corpus callosum and the left anterior corona radiata (p < 0.05). Covariance analysis revealed that the BDSI + group exhibited significantly lower FA values in these regions compared to the HCs (p < 0.05). Partial correlation analyses showed that the FA values in the genu of corpus callosum were negatively correlated with BSSI scores (r = -0.592, p = 0.026) and TMT-A scores (r = -0.642, p = 0.013). The findings from this study suggest that alterations in the connectivity of the genu of the corpus callosum may relate to suicidal ideation and visuospatial function in patients with bipolar depression.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"911-918"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cognitive elements plays in physical activity interventions among individuals with attention-deficit/hyperactivity disorder: A systematic review of brain evidence. 认知因素在注意缺陷/多动障碍个体的身体活动干预中所起的作用：对大脑证据的系统回顾。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1007/s11682-025-01027-4

Yuan Fang, Fenghua Sun, Zixin Wang, Yaxi Yang, Man Lau, Kunyi Huang, Michael Kin-Chung Yeung, Simon B Cooper, Yajun Chen

引用次数: 0

Characteristic alterations of dynamic amplitude of low-frequency fluctuation in patients with post-stroke depression. 脑卒中后抑郁患者低频波动动态幅度的特征性改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI: 10.1007/s11682-025-01014-9

Qiuhong Lu, Shunzu Lu, Xue Wang, Yanlan Huang, Jie Liu, Qiuhui Huang, Hua Huang, Zhijian Liang

{"title":"Characteristic alterations of dynamic amplitude of low-frequency fluctuation in patients with post-stroke depression.","authors":"Qiuhong Lu, Shunzu Lu, Xue Wang, Yanlan Huang, Jie Liu, Qiuhui Huang, Hua Huang, Zhijian Liang","doi":"10.1007/s11682-025-01014-9","DOIUrl":"10.1007/s11682-025-01014-9","url":null,"abstract":"The abnormalities in static brain activity in patients with post-stroke depression (PSD) have been widely reported; the abnormal alterations and characterized clustering model of the dynamic neural activity in PSD remain enigmatic. We investigated dynamic neural activity abnormalities in patients with PSD with the dynamic amplitude of low-frequency fluctuation (dALFF) method. Imaging and clinical data from 25 patients with PSD and 28 without PSD collected from April 2020 to June 2023 were evaluated. The between-group comparisons of dALFF variance and state properties were conducted using a combined approach of sliding window and clustering analysis. The correlation coefficients between abnormal dALFF variance and ALFF in the distinguished regions (DRs) and depression severity of PSD were calculated. Compared with that in patients without PSD, decreased dALFF variance in patients with PSD was mainly located in lower dALFF variance in multiple emotion-related brain regions. The dALFF was clustered into four states in all patients. In particular, state 3 was the remarkably distinct state that dwelled for more time in the PSD group. There was a negative correlation between decreased dALFF variance in the right parietal cortex and Hamilton Rating Scale for Depression (HAMD) scores in patients with PSD. ALFF values in the DRs showed no correlation with the HAMD score. Our results suggest that patients with PSD showed characteristic alterations in dynamic regional neural activity, which might be regarded as potential neural mechanisms of PSD. This study demonstrates the dynamic features of neural activity in PSD, which may advance future neuroimaging studies.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"889-898"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal brain networks in Meiges syndrome based on centrality analysis and functional network connectivity: a cross-sectional analysis. 基于中心性分析和功能网络连通性的Meiges综合征异常脑网络：横断面分析。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-29 DOI: 10.1007/s11682-025-01000-1

Yifei Wang, Aocai Yang, Zeyu Song, Yu Chen, Guolin Ma, Xiaoying Tang

{"title":"Abnormal brain networks in Meiges syndrome based on centrality analysis and functional network connectivity: a cross-sectional analysis.","authors":"Yifei Wang, Aocai Yang, Zeyu Song, Yu Chen, Guolin Ma, Xiaoying Tang","doi":"10.1007/s11682-025-01000-1","DOIUrl":"10.1007/s11682-025-01000-1","url":null,"abstract":"Background: Meige's syndrome (MS) is a neurologically disabling disorder characterized by visual impairment, mastication, and swallowing difficulties. Emerging evidence suggests that MS may stem from disturbances in brain networks. However, current literature inadequately probes the centrality and functional connectivity within these networks.Purpose: This study aims to compare the brain networks of MS patients with those of healthy controls (HC). We focus on examining changes in intrinsic connectivity, the significance of nodes within the global brain network, and functional network connectivity (FNC). Additionally, we seek to identify potential correlations between neuroimaging findings and clinical scales.Method: In this cross-sectional study, we employed centrality analysis and mediation analysis of brain networks using resting-state fMRI data. Voxel-level degree centrality (DC) and eigenvector centrality (EC) served as key features. Independent component analysis was utilized to assess functional connectivity at the network level.Results: Analyses of EC and DC identified abnormal areas in MS patients predominantly in the right thalamus, left middle occipital gyrus, and Cerebellum Inferior. Mediation analysis indicated that disease severity and course of disease are fully mediated by DC values in the right cerebellum. FNC results highlighted abnormal connections in cerebellar-subcortical, memory retrieval-cingulo-opercular task control, and ventral attention-sensory/somatomotor hand networks in MS patients.Conclusions: Our findings reveal multiple abnormalities in centrality and functional connectivity of brain networks in MS patients. Notably, disease severity correlates with alterations in these, potentially influencing disease progression.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"899-910"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical segregation of frontoparietal and sensorimotor networks is related to social and executive function impairments in children with ASD. 额顶叶和感觉运动网络的非典型分离与ASD儿童的社会和执行功能障碍有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-19 DOI: 10.1007/s11682-025-01016-7

Alina Minnigulova, Olga Dragoy, Vardan Arutiunian

{"title":"Atypical segregation of frontoparietal and sensorimotor networks is related to social and executive function impairments in children with ASD.","authors":"Alina Minnigulova, Olga Dragoy, Vardan Arutiunian","doi":"10.1007/s11682-025-01016-7","DOIUrl":"10.1007/s11682-025-01016-7","url":null,"abstract":"Two possible indicators of a deficient segregation of functional networks are within-underconnectivity and between-overconnectivity. Both these processes can be observed in Autism Spectrum Disorder (ASD) to be associated with different core and co-occurring atypicalties of behavior. We focused on within- and between-network connectivity of Frontoparietal and Sensorimotor networks in ASD compared to typically developed (TD) peers and its links to social difficulties and impairments of executive and motor functions. To our knowledge, this study for the first time described between-network connectivity of Frontoparietal and Sensorimotor networks in ASD with relations to symptoms of ASD. In this study, we utilised resting-state functional MRI to investigate 121 participants with ASD and 84 TD children. We investigated between-group differences of the connectivity between Frontoparietal and Sensorimotor regions. We also conducted brain-behavior analysis for beta values of these connections and behavioral scores. Controlling for age and sex, we found a significant group difference within- Frontoparietal network (right and left posterior parietal cortices were underconnected in ASD) and between-networks (right posterior parietal and right lateral sensorimotor cortices were overconnected in ASD). In the ASD group, we also showed that within-Frontoparietal underconnectivity was related to lower scores of social and executive functions as well as between-networks overconnectivity was associated with social difficulties only. There were no significant relationships between scores of motor functions and beta values. We confirmed the hypothesis of deficient segregation for Frontoparietal and Sensorimotor networks in ASD. These findings highlight the importance of between-network connectivity investigation.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"846-855"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical volumes, frontal cortical thickness, and pro-inflammatory cytokines in schizophrenia versus methamphetamine-induced psychosis. 精神分裂症与甲基苯丙胺所致精神病的皮质下体积、额叶皮质厚度和促炎性细胞因子。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-05-28 DOI: 10.1007/s11682-025-01022-9

Lauren Blake, Kimberley C Williams, Anne A Uhlmann, Henk Temmingh, Antoinette Burger, Dan J Stein, Petrus J W Naudé

{"title":"Subcortical volumes, frontal cortical thickness, and pro-inflammatory cytokines in schizophrenia versus methamphetamine-induced psychosis.","authors":"Lauren Blake, Kimberley C Williams, Anne A Uhlmann, Henk Temmingh, Antoinette Burger, Dan J Stein, Petrus J W Naudé","doi":"10.1007/s11682-025-01022-9","DOIUrl":"10.1007/s11682-025-01022-9","url":null,"abstract":"Schizophrenia is associated with alterations in subcortical volumes, cortical thickness and pro-inflammatory cytokines, that may correlate with clinical features. However, analogous work on methamphetamine-induced psychosis is lacking. This study examines subcortical volumes, frontal cortical thickness and pro-inflammatory cytokines in schizophrenia and methamphetamine-induced psychosis.Diagnosis and symptom severity were determined using the Structured Clinical Interview for Axis I Disorders and the Positive and Negative Syndrome Scale, respectively. Structural T1-weighted images were acquired using a 3-Tesla magnetic resonance imaging scanner. Serum peripheral cytokine concentrations were measured using a multiplex bead array.Schizophrenia (n = 36) and methamphetamine-induced psychosis (n = 27) participants showed decreased left amygdala volumes and frontal cortical thickness compared to healthy controls (n = 32). Schizophrenia participants had increased bilateral caudate, putamen, and nucleus accumbens volumes compared to controls, and greater right globus pallidus and nucleus accumbens volumes compared to the methamphetamine-induced psychosis group. No significant differences were found in cytokine levels between groups or associations with neuroimaging measures.The novel discovery of increased globus pallidus and nucleus accumbens volumes in schizophrenia group compared with methamphetamine-induced psychosis group may show important distinctions in the neurobiology between these conditions. Future investigations should employ larger sample sizes, incorporate longitudinal study designs, and integrate magnetic resonance spectroscopy which may show important neurometabolic signatures in these brain regions in methamphetamine-induced psychosis.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"874-888"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of glucocorticoid therapy on brain white matter microstructure in thyroid-associated ophthalmopathy: a longitudinal diffusion kurtosis imaging study. 糖皮质激素治疗对甲状腺相关性眼病脑白质微结构的影响：纵向扩散峰度成像研究。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-08-01 Epub Date: 2025-06-01 DOI: 10.1007/s11682-025-01025-6

Qian Wu, Jin-Ling Lu, Jiang Zhou, Xiong-Ying Pu, Huan-Huan Chen, Fei-Yun Wu, Xiao-Quan Xu, Hao Hu

{"title":"Effect of glucocorticoid therapy on brain white matter microstructure in thyroid-associated ophthalmopathy: a longitudinal diffusion kurtosis imaging study.","authors":"Qian Wu, Jin-Ling Lu, Jiang Zhou, Xiong-Ying Pu, Huan-Huan Chen, Fei-Yun Wu, Xiao-Quan Xu, Hao Hu","doi":"10.1007/s11682-025-01025-6","DOIUrl":"10.1007/s11682-025-01025-6","url":null,"abstract":"To investigate the changes in brain white matter microstructure in patients with thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid therapy using diffusion kurtosis imaging (DKI) with tract-based spatial statistics (TBSS) method. Twenty TAO patients and 20 healthy controls were enrolled for clinical and magnetic resonance imaging (MRI) examinations. All patients had intravenous glucocorticoid therapy, followed by MRI scans and clinical assessments three months after the treatment ended. TBSS was used to evaluate the mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), kurtosis fractional anisotropy, fractional anisotropy (FA) and mean diffusion of brain white matter. At baseline, TAO patients showed significantly decreased MK, AK, RK and FA in extensive white matter tracts compared to controls. After therapy, increased MK and AK were observed in comparison to the pre-therapy cohort. However, post-therapy TAO patients still exhibited reduced RK in partial white matter tracts compared to controls. RK values in left posterior thalamic radiation (PTR) showed a negative correlation with CAS in pre-therapy TAO patients. Meanwhile, RK values in left PTR were positively correlated with quality of life scores for visual functioning, and RK values in left anterior corona radiata were negatively correlated with anxiety scores in post-therapy TAO patients. Our findings suggested that TAO could lead to white matter deficits in the visual, cognitive, and emotional brain areas, which were partially restored after treatment.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"919-929"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0