Brain Imaging and Behavior最新文献

{"title":"Investigation of the effective connectivity between the anti-NMDAR encephalitis default mode network and the medial temporal lobe network using spectral dynamic causal modelling.","authors":"Zijun Liu, Muzi Li, Jingwen Li, Guang Xu, Junzhang Tian, Xiaofen Ma","doi":"10.1007/s11682-025-01041-6","DOIUrl":"https://doi.org/10.1007/s11682-025-01041-6","url":null,"abstract":"<p><strong>Background: </strong>Research has indicated that anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis involves global network dysfunction, linking memory deficits to connectivity in the hippocampus, default mode network (DMN), and medial temporal lobe network (MTL). Most relevant cognitive studies have focused on functional connectivity (FC) rather than effective connectivity (EC), meaning that the directed interactions and causal relationships between the DMN and MTL remain unexplored.</p><p><strong>Methods: </strong>Herein, we collected resting-state functional MRI (fMRI) data from 23 patients with anti-NMDAR encephalitis (mean age 30.04 ± 12.67 years) and 23 matched controls (mean age 28.87 ± 9.36 years). Spectral dynamic causal modelling (spDCM) was applied to assess the effective connectivity among the 12 predefined regions of interest in the DMN and MTL.</p><p><strong>Results: </strong>Effective connectivity (EC) within and between the DMN and MTL networks significantly differed in the NMDAR-resistant encephalitis group compared to controls; the positive EC within the DMN and from the MTL to the DMN was enhanced, while the negative EC from the DMN to the MTL increased, and the positive EC within the MTL decreased. The mean DMN connectivity values in the anti-NMDAR group were negatively correlated with California Verbal Learning Test (CVLT) and Modified Mental State Examination (MMSE) scores, an effect which remained significant after adjusting for age, sex, and body mass index.</p><p><strong>Conclusion: </strong>This study identified differences in the connectivity between the DMN and MTL networks in patients with post-acute anti-NMDAR encephalitis, suggesting a possible disconnection. The parahippocampal gyrus (PHG) mediates connections between the hippocampus and the posterior cingulate cortex (PCC). Structural or functional loss of the PHG may affect the integration between the MTL memory system and DMN nodes, correlating with cognitive deficits. This study provides crucial results to improve our understanding of the directed integration between the DMN and MTL networks, providing new evidence.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults.","authors":"Marie-Chantal Ferland, Ruiqi Wang, Jean-Marc Therrien-Blanchet, Sarah Remahi, Samantha Côté, Ann-Jessica Fréchette, Thien Thanh Dang-Vu, Hesheng Liu, Jean-François Lepage, Hugo Théoret","doi":"10.1007/s11682-025-01043-4","DOIUrl":"https://doi.org/10.1007/s11682-025-01043-4","url":null,"abstract":"<p><p>Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this placebo-controlled, crossover study, twenty healthy adult participants (9 women; 26.2 ± 5.2 years) underwent two resting-state fMRI (rs-fMRI) scans following administration of either lorazepam (2.5 mg) or placebo. Imaging data were analyzed using an individual brain network parcellation approach and differences in functional connectivity among 78 individual-specific ROIs were estimated. Compared to placebo, functional connectivity was reduced following administration of lorazepam between the left medial paracentral lobule and left temporal pole and between the left posterior cingulate sulcus and right cuneus. Reduced connectivity within higher-order cognitive networks partly supports what has been reported for other benzodiazepines such as midazolam and alprazolam. However, differences across benzodiazepines - possibly due to pharmacokinetics, dosage and receptor selectivity - underscore the need for further research.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural connectivity of hippocampus is not altered in patients with type 2 diabetes and without peripheral microangiopathy.","authors":"Lian Liu, Ke Xu, Qian Luo, TingTing Shen, Mei Kang, MingMing Ma, YuFan Wang, Fang Fang","doi":"10.1007/s11682-025-01038-1","DOIUrl":"https://doi.org/10.1007/s11682-025-01038-1","url":null,"abstract":"<p><p>Functional hyper-connectivity in hippocampus has been recently observed in patients with an early stage of type 2 diabetes, however, the structural connectivity between hippocampus and other regions of the brain and its effects on neuropsychological performance are still unknown. Participants (82 patients with type 2 diabetes and without peripheral microvascular complications; 75 healthy controls) underwent detailed cognitive assessment and diffusion MRI. Probabilistic tractography based on a multifiber model was performed to investigate the fiber connections between hippocampus and other regions of the brain. The differences in hippocampal connectivity between groups were compared with age, sex, body mass index and education as covariates. The association between hippocampal connectivity and cognitive performances in patients with diabetes were further investigated. Patients had lower Stroop Accuracy and longer Stroop Reaction Time compared with age-, sex-, education-matched controls. Although lower hippocampal connectivities to widespread brain regions were observed in diabetic group, there were no statistical differences after FDR adjustment. Moreover, the strength of fiber connections was not associated with any cognitive performance in patients with diabetes. Taken together, worse executive function was observed in patients with an early stage of type 2 diabetes. However, it might not be related to hippocampal fiber connectivity. These findings suggested that structural connectivity in hippocampus was not an early predictor for diabetes-associated cognitive decrements.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal or contextual? Rethinking brain structure-function links in autism through cross-cultural lenses.","authors":"Riza Amalia, Henny Indreswari, Ajeng Ayu Widiastuti","doi":"10.1007/s11682-025-01042-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01042-5","url":null,"abstract":"","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling anomalies in visual processing regions in obsessive-compulsive disorder: evidence from gray matter volume and functional connectivity analyses.","authors":"Rui Liu, Fengxia Zhang, Pengchong Wang, Jia Luo, Yue Liu, Kaiyin Huang, Xiangyun Yang, Aihong Yu, Zhanjiang Li","doi":"10.1007/s11682-025-01039-0","DOIUrl":"https://doi.org/10.1007/s11682-025-01039-0","url":null,"abstract":"<p><p>Obsessive-compulsive disorder (OCD) is a prevalent neurological condition characterized by recurring obsessive thoughts and compulsive behaviors. The underlying mechanisms of the disorder remain poorly understood due to its considerable heterogeneity. Given the extensive brain impairments observed in OCD, this study aimed to investigate gray matter volume and functional connectivity in individuals with OCD using a multimodal neuroimaging approach, while also exploring the relationship between these neural changes and clinical symptom severity. Structural and resting-state functional magnetic resonance imaging data were collected from 56 OCD patients and 41 healthy controls. Voxel-based morphometry analysis was employed to identify gray matter volume differences between the patient and control groups. Compared to healthy controls, patients exhibited reduced gray matter volume in visual processing regions, including the cuneus, left calcarine, and middle occipital gyrus. Furthermore, whole-brain functional connectivity analysis was conducted on these regions with abnormal gray matter volume, showing increased connectivity between the visual processing areas and subcortical and prefrontal regions. Additionally, gray matter volume reductions in the left calcarine and middle temporal gyrus were significantly correlated with higher scores on the Yale-Brown Obsessive Compulsive Scale, suggesting a link between visual processing abnormalities and the severity of clinical symptoms. These findings highlight structural and functional alterations in visual-related brain regions as key contributors to the pathophysiology of OCD, providing valuable insights into its neural basis and potential avenues for therapeutic intervention.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and pragmatic language skills in school-age children relate to resting state functional connectivity.","authors":"Julia C Hoyda, Hannah J Stewart, Jennifer Vannest, Karla N Washington, David R Moore","doi":"10.1007/s11682-025-01040-7","DOIUrl":"https://doi.org/10.1007/s11682-025-01040-7","url":null,"abstract":"<p><p>Language difficulties are common in school-age children but their etiology is often unknown. Although neural underpinnings of language have been well-studied in neurotypical individuals, functional connectivity differences between children with language difficulties and their typically-developing peers have not. There is little evidence regarding patterns of neural connectivity for children with language difficulties. Differences in neural networks related to degree of language difficulties and subtype of language skills (structural or pragmatic) are unclear. We examined expressive and receptive language networks, and an executive function network, in school-age children (8-12 years, n = 81) relative to their caregiver-reported language skills. We hypothesized that children with poorer structural and pragmatic language skills would have decreased connectivity in these networks. Participants were separated into groups by structural and pragmatic language scores: those with structural language difficulties (SLD), pragmatic language difficulties (PLD), and combined language difficulties (CLD, consisting of some participants in both SLD and PLD). The remainder of participants were in the typical language (TL) group. Results showed trends toward increased cross-hemispheric connectivity in age-matched controls relative to those with poorer language skills. Specifically, connectivity between bilateral inferior frontal gyri and areas including bilateral supplementary motor areas, cerebellar regions, and bilateral frontal gyri was associated with higher structural and pragmatic language scores. Connectivity among additional regions including bilateral superior temporal gyri and Heschl's gyrus showed both positive and negative correlation with both language scores. This suggests that reduced connectivity between regions involved in language processing may contribute to language difficulties in school-age children.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity of sensory and executive function networks during a story listening task is related to parent/child interaction during joint reading: a functional MRI diffusion map study.","authors":"Tzipi Horowitz Kraus, Marwan Bebar, Adi Jacobson, John Hutton","doi":"10.1007/s11682-025-01037-2","DOIUrl":"https://doi.org/10.1007/s11682-025-01037-2","url":null,"abstract":"<p><p>The quality of parent-child interaction during shared reading (\"shared reading quality\") is strongly linked to cognitive and relational benefits. However, the relationship between shared reading quality and activation and synchronization of reading-related brain networks has not yet been characterized. The current study involved 22 4-year-old girls who completed functional MRI including a validated stories listening task, and a primary parent. Prior to MRI, video observation of the parent and child reading together was conducted and later coded using a standardized scoring form quantifying parent-child verbal and nonverbal interaction. Behavioral measures included demographics and a maternal depression scale. To achieve this goal, fMRI stories-listening data was utilized to create a diffusion maps algorithm and then to classify the level of parent-child interaction during the shared reading observation. The algorithm clustered children with higher parent-child engagement scores with fMRI diffusion patterns in regions of the brain known to support reading. This study establishes proof-of-concept that applying this diffusion maps algorithm to brain functional connectivity data can reliably predict parent-child interaction during shared book reading. It also suggests that an algorithmic approach may be a novel, data-driven means to quantify parent-child interaction in different contexts (e.g., reading, play) and populations.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter microstructure in language tracts in youth with perinatal stroke.","authors":"Bryce L Geeraert, Brian L Brooks, Adam Kirton, Helen L Carlson","doi":"10.1007/s11682-025-01011-y","DOIUrl":"https://doi.org/10.1007/s11682-025-01011-y","url":null,"abstract":"<p><p>Perinatal strokes occur more commonly in the left hemisphere and often impact language areas, yet language disability only occurs in a small proportion of cases. Functional imaging studies investigating language processing have shown that perinatal stroke in the left hemisphere may result in contralesional shifts of activity, but none have investigated the structure of white matter connections in such altered language network conditions. Diffusion tensor imaging and neurite orientation dispersion and density imaging offer robust, microstructurally-sensitive metrics which can richly characterize tracts known to support language function. In a sample of 105 participants aged 6 to 19, 73 participants with perinatal stroke and 32 typically-developing controls, we applied these techniques to evaluate differences in microstructure of the arcuate fasciculus and uncinate fasciculus, two tracts classically associated with language, following perinatal stroke while controlling for age, sex, and lesion volume. We identified widespread differences in microstructure in both hemispheres for the arcuate and uncinate fasciculi in perinatal stroke participants compared to controls. Subtypes of perinatal stroke presented differently, with arterial ischemic stroke lesions showing more structural differences than periventricular infarction lesions. Differences between perinatal stroke subtypes were observed for both tracts in both hemispheres. Overall, we demonstrate that white matter microstructure of bilateral language networks is impacted by unilateral perinatal stroke. These bilateral differences in white matter structure after unilateral injury suggest that neuroplastic mechanisms may operate in both hemispheres during development with possible functional implications that could inform customized patient-centered rehabilitation strategies.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex effects on dynamic structure-function coupling of intrinsic brain network.","authors":"Xi Zhang, Dandan Li, Yuting Yuan, Xuebing Han, Lan Yang, Jiayu Lu, Ting Li, Zhifeng Li, Bin Wang","doi":"10.1007/s11682-025-01036-3","DOIUrl":"https://doi.org/10.1007/s11682-025-01036-3","url":null,"abstract":"<p><p>Sex differences in static structure-function coupling between structural connectivity (SC) and functional connectivity (FC) have been documented. However, the human brain is highly dynamic, and static coupling fails to capture the time-varying properties of neural activity. It remains unclear how sex influences dynamic SC-FC coupling over time. Moreover, intrinsic functional networks represent a core feature of brain organization. Here, we quantified sex differences in dynamic FC strength and SC-FC coupling at the intrinsic functional network level using a sliding window approach. Using two window sizes (50 TRs and 30 TRs), we constructed dynamic FC networks and identified hyper-connected and hypo-connected states via k-means clustering. The results showed females performed higher whole-brain SC-FC coupling in hyper-connected state. Specifically, females exhibited higher FC strength and coupling in systems related default mode network in this state. In addition, females exhibited higher FC strength and coupling in systems related limbic/paralimbic and subcortical network in hypo-connected state. Males exhibited higher FC strength and coupling in systems related somatosensory/motor and auditory network in hyper-connected state. Finally, sex-specific patterns in correlations were shown between SC-FC coupling and cognitive performance in distinct states. This study provides new insights into sex-related effects on the neurodevelopmental basis of cognitive function through the perspective of dynamic SC-FC coupling.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of functional and structural topological organization in specific subnetwork among patients with classical trigeminal neuralgia: a graph theory-based magnetic resonance imaging study.","authors":"Linhua Huang, Meng Li, Yuying Chen, Qianling Zhou, Jinyan Chen, Jianhao Yan","doi":"10.1007/s11682-025-01035-4","DOIUrl":"https://doi.org/10.1007/s11682-025-01035-4","url":null,"abstract":"","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}