Brain Imaging and Behavior最新文献

Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective. 严重精神疾病高危青少年的大脑连接体：纵向视角。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-11-08 DOI: 10.1007/s11682-024-00953-z

Mohammed K Shakeel, Paul D Metzak, Mike Lasby, Xiangyu Long, Roberto Souza, Signe Bray, Benjamin I Goldstein, Glenda MacQueen, JianLi Wang, Sidney H Kennedy, Jean Addington, Catherine Lebel

{"title":"Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective.","authors":"Mohammed K Shakeel, Paul D Metzak, Mike Lasby, Xiangyu Long, Roberto Souza, Signe Bray, Benjamin I Goldstein, Glenda MacQueen, JianLi Wang, Sidney H Kennedy, Jean Addington, Catherine Lebel","doi":"10.1007/s11682-024-00953-z","DOIUrl":"https://doi.org/10.1007/s11682-024-00953-z","url":null,"abstract":"Identifying biomarkers for serious mental illnesses (SMI) has significant implications for prevention and early intervention. In the current study, changes in whole brain structural and functional connectomes were investigated in youth at transdiagnostic risk over a one-year period. Based on clinical assessments, participants were assigned to one of 5 groups: healthy controls (HC; n = 33), familial risk for serious mental illness (stage 0; n = 31), mild symptoms (stage 1a; n = 37), attenuated syndromes (stage 1b; n = 61), or discrete disorder (transition; n = 9). Constrained spherical deconvolution was used to generate whole brain tractography maps, which were then used to calculate connectivity matrices for graph theory analysis. Graph theory was also used to analyze correlations of functional magnetic resonance imaging (fMRI) signal between pairs of brain regions. Linear mixed models revealed structural and functional abnormalities in global metrics of small world lambda, and resting state networks involving the fronto-parietal, default mode, and deep grey matter networks, along with the visual and dorsal attention networks. Machine learning analysis additionally identified changes in nodal metrics of betweenness centrality in the angular gyrus and bilateral temporal gyri as potential features which can discriminate between the groups. Our findings further support the view that abnormalities in large scale networks (particularly those involving fronto-parietal, temporal, default mode, and deep grey matter networks) may underlie transdiagnostic risk for SMIs.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromelanin-MRI identifies locus coeruleus and substantia nigra degeneration as key differentiators in isolated rapid eye movement sleep behavior disorder. 神经黑素-核磁共振成像（Neuromelanin-MRI）确定黑质和黑质变性是孤立性快速眼动睡眠行为障碍的关键分化因素。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-30 DOI: 10.1007/s11682-024-00926-2

Junyan Fu, Ye Tang, Lei Pan, Kun Lv, Xin Cao, Siting Xu, Daoying Geng, Huan Yu, Jun Zhang

{"title":"Neuromelanin-MRI identifies locus coeruleus and substantia nigra degeneration as key differentiators in isolated rapid eye movement sleep behavior disorder.","authors":"Junyan Fu, Ye Tang, Lei Pan, Kun Lv, Xin Cao, Siting Xu, Daoying Geng, Huan Yu, Jun Zhang","doi":"10.1007/s11682-024-00926-2","DOIUrl":"https://doi.org/10.1007/s11682-024-00926-2","url":null,"abstract":"To explore the neuromelanin depigmentation of locus coeruleus (LC) and substantia nigra pars compacta (SNc) in the isolated rapid eye movement sleep behavior disorder (iRBD) using neuromelanin-sensitive MRI (NM-MRI), and to evaluate its utility for iRBD diagnosis. A total of 25 iRBD patients and 25 healthy controls were recruited and underwent NM-MRI. The contrast-to-noise ratio (CNR) of SNc and LC, and the volume of SNc were compared between groups and evaluated visually. The power of NM measures in discriminating iRBD patients from healthy controls were performed with receiver operating characteristic (ROC) curves and the area under curve (AUC) was calculated. The CNR of SNc and LC, the volume of SNc, the SNc/midbrain volume ratio as well as the visual scores of SNc and LC in iRBD patients were significantly decreased than those in controls (all P < 0.05). For quantitative analysis, the LC CNR acquired the highest accuracy in predicting iRBD (AUC 0.95, sensitivity 80%, specificity 100%), followed by SNc volume (AUC 0.93, sensitivity 88%, specificity 96%) and SNc CNR (AUC 0.74, sensitivity 92%, specificity 44%). For visual analysis, the accuracy of the visual score for SNc and LC were 78% (sensitivity 68%, specificity 88%) and 86% (sensitivity 88%, specificity 84%), respectively. The NM in the SNc and LC regions were significantly reduced in iRBD patients. NM measures showed good capability in discriminating iRBD from controls, suggesting that NM-MRI may be a valuable screening tool for iRBD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping common and distinct brain correlates among cognitive flexibility tasks: concordant evidence from meta-analyses. 绘制认知灵活性任务中共同和独特的大脑相关性：来自元分析的一致证据。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-29 DOI: 10.1007/s11682-024-00921-7

Zhanna V Chuikova, Andrei A Filatov, Andrei Y Faber, Marie Arsalidou

{"title":"Mapping common and distinct brain correlates among cognitive flexibility tasks: concordant evidence from meta-analyses.","authors":"Zhanna V Chuikova, Andrei A Filatov, Andrei Y Faber, Marie Arsalidou","doi":"10.1007/s11682-024-00921-7","DOIUrl":"https://doi.org/10.1007/s11682-024-00921-7","url":null,"abstract":"Cognitive flexibility allows individuals to switch between different tasks, strategies, or ideas; an ability that is important for everyday life. The Wisconsin card sorting test (WCST) and task switching paradigm (TSP) are popular measures of cognitive flexibility. Although both tasks require switching, the TSP requires participants to memorize switching rules and retrieve them when they view a cue (rule-retrieval), whereas the classic WCST requires participants to discover the switching rule via trial-and-error (rule-discovery). Many functional magnetic resonance imaging studies have examined brain responses to these tasks. Extant meta-analyses show concordance in activation in a widespread set of areas including frontal, parietal, and cingulate cortices. Critically, past meta-analyses have not specifically examined brain correlates associated with rule derivation (i.e., rule-discovery vs. rule-retrieval) in cognitive flexibility tasks. We examine for the first time common and distinct concordance in brain responses to rule-discovery (i.e., WCST) and rule-retrieval (i.e., TSP), as well as TSP subtypes using quantitative meta-analyses. We analyzed data from 69 eligible articles with a total of 1617 young-adult participants. Conjunction results show concordance in common fronto-parietal areas predominantly in the left hemisphere. Contrast analyses show that rule-discovery required increased involvement in multiple cortical and subcortical regions such as frontopolar (Brodmann Area 10), parietal, insular cortex, thalamus and caudate nucleus predominantly in the right hemisphere. No significant differences in concordance were observed among the three, task switching paradigm sub-types. We propose a neuroanatomical model of cognitive flexibility and discuss theoretical and practical applications.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal percent amplitude of fluctuation in patients with lifelong premature ejaculation is associated with neurotransmitter profiles. 终生早泄患者异常的百分比波动幅度与神经递质特征有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-25 DOI: 10.1007/s11682-024-00920-8

Jiarui Yuan, Pinxiao Wang, Dingxin Nie, Wanxiang Zheng, Kepu Liu, Jianyong Feng, Yuntao Zhang, Yanzhu Wang, Junjun Gao, Ming Gao

{"title":"Abnormal percent amplitude of fluctuation in patients with lifelong premature ejaculation is associated with neurotransmitter profiles.","authors":"Jiarui Yuan, Pinxiao Wang, Dingxin Nie, Wanxiang Zheng, Kepu Liu, Jianyong Feng, Yuntao Zhang, Yanzhu Wang, Junjun Gao, Ming Gao","doi":"10.1007/s11682-024-00920-8","DOIUrl":"https://doi.org/10.1007/s11682-024-00920-8","url":null,"abstract":"Identifying additional imaging biomarkers of lifelong premature ejaculation (LPE) may provide valuable insights into understanding the underlying neural mechanisms of this disorder. Forty-six LPE patients and thirty-five healthy controls (HCs) were enrolled in this study. The Percent Amplitude of Fluctuation (PerAF) method was used to assess differences in brain function in LPE patients compared to HCs during the resting-state. Receiver operating characteristic (ROC) analysis was used to investigate the potential biomarkers based on the imaging findings. Correlation analysis was then applied to examine the relationships between the neuroimaging findings and clinical symptoms. We also investigated whether PerAF alterations in LPE patients were associated with specific neurotransmitter systems. Compared to HCs, LPE patients showed increased PerAF in the middle cingulate cortex (MCC), supramarginal gyrus, Rolandic operculum, parahippocampus/hippocampus (ParaHIPP/HIPP) as well as insula; and decreased PerAF in the precuneus, inferior temporal cortex plus occipital cortex. The MCC and ParaHIPP/HIPP exhibited higher classification performance on ROC analysis. Positive correlations were found between the Premature Ejaculation Diagnostic Tool score and PerAF in the insula, and the International Index of Erectile Function score and PerAF in the precuneus. Additionally, altered PerAF in LPE patients correlated significantly with the spatial distribution of dopamine, acetylcholine and epinephrine pathways. Our findings indicate that LPE patients have PerAF-related changes in certain brain regions associated with visual, sensory and/or emotional processing, and reveal that the abnormal control of ejaculatory function may be related to the combined dysregulation of neurotransmitter systems in LPE patients.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the hippocampal subfield changes across the Alzheimer's disease continuum: a systematic review of neuroimaging studies. 揭示阿尔茨海默氏症连续过程中海马亚区的变化：神经影像学研究的系统回顾。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-23 DOI: 10.1007/s11682-024-00952-0

Alessandro Zilioli, Beatrice Pancaldi, Hannah Baumeister, Gabriele Busi, Francesco Misirocchi, Carlotta Mutti, Irene Florindo, Nicola Morelli, Rosaleena Mohanty, David Berron, Eric Westman, Marco Spallazzi

{"title":"Unveiling the hippocampal subfield changes across the Alzheimer's disease continuum: a systematic review of neuroimaging studies.","authors":"Alessandro Zilioli, Beatrice Pancaldi, Hannah Baumeister, Gabriele Busi, Francesco Misirocchi, Carlotta Mutti, Irene Florindo, Nicola Morelli, Rosaleena Mohanty, David Berron, Eric Westman, Marco Spallazzi","doi":"10.1007/s11682-024-00952-0","DOIUrl":"https://doi.org/10.1007/s11682-024-00952-0","url":null,"abstract":"Studies exploring the hippocampal subfield atrophy in Alzheimer's disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyloid status and reported data on hippocampal subfield atrophy using advanced MRI techniques. Twelve studies were included. Despite high heterogeneity, a distinguishable pattern of vulnerability of hippocampal subfields can be recognized from the cognitively unimpaired phase to the dementia stage, shedding light on hippocampal changes with disease progression. Consistent findings revealed atrophy in the subiculum and presubiculum, along with a potential increase in volume in the cornu ammonis (CA) among the cognitively unimpaired group, a feature not observed in patients experiencing subjective cognitive decline. Atrophy in the subiculum, presubiculum, CA 1-4, and the dentate gyrus characterized the mild cognitive impairment stage, with a more pronounced severity in the progression to dementia.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale structural covariance networks changes relate to executive function deficit in betel quid-dependent chewers. 大规模结构协方差网络变化与槟榔依赖咀嚼者的执行功能缺陷有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-19 DOI: 10.1007/s11682-024-00950-2

Yihao Guo, Tao Liu, Xiaoling Xu, Tiansheng Li, Xiaoli Xiong, Huijuan Chen, Weiyuan Huang, Xianchang Zhang, Feng Chen

{"title":"Large-scale structural covariance networks changes relate to executive function deficit in betel quid-dependent chewers.","authors":"Yihao Guo, Tao Liu, Xiaoling Xu, Tiansheng Li, Xiaoli Xiong, Huijuan Chen, Weiyuan Huang, Xianchang Zhang, Feng Chen","doi":"10.1007/s11682-024-00950-2","DOIUrl":"https://doi.org/10.1007/s11682-024-00950-2","url":null,"abstract":"Previous studies demonstrate deficits in executive function for betel quid-dependent (BQD) patients. Large-scale structural covariance network (SCN) based on gray matter (GM) morphometry may be able to explore the neural mechanism of executive dysfunction in BQD individuals. This study aims to identify spatial covariance patterns of GM volume and to investigate their association with executive dysfunction in BQD individuals. Sixty-four BQD individuals and 48 sex- and age-matched healthy controls (HCs) underwent T1-weighted structural MRI examination and executive function assessments, including the Backward Digit Span (BDS) test and Stroop Color and Word (SCW) test. Seventy SCNs based on GM volume covariance patterns were defined using independent component analysis. An SCN-based classifier was constructed to differentiate between BQD and HC individuals. Receiver operating characteristic (ROC) curves were applied to evaluate the performance of the SCN-based classifier. Linear regression analyses were performed to investigate the association between SCN network indices and executive function indices. Six SCNs had higher classifications for differentiating between BQD and HC individuals. The area under the ROC curve of the SCN-based classifier was 0.812 in the training set and 0.771 in the testing set. Furthermore, linear regression analyses demonstrated that the network indices in the thalamus were associated with BDS scores adjusted for age, sex, and education. Large-scale SCNs could provide potential imaging markers for differentiating BQD and HC groups. The loss of network index in the thalamus was associated with working memory, indicating that SCNs could reveal executive dysfunction in BQD individuals.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus. 咽球患者丘脑亚区静息态功能连接的改变

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-17 DOI: 10.1007/s11682-024-00940-4

Yuanyuan Hu, Jingjie Zhao, Yuening Jin, Yi Du, Qian Zhao, Shuai Xu, Li Li, Yuan Zhou

{"title":"The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus.","authors":"Yuanyuan Hu, Jingjie Zhao, Yuening Jin, Yi Du, Qian Zhao, Shuai Xu, Li Li, Yuan Zhou","doi":"10.1007/s11682-024-00940-4","DOIUrl":"https://doi.org/10.1007/s11682-024-00940-4","url":null,"abstract":"Globus Pharyngeus (GP) is a somatic symptom that accompanies mood distress. Although the etiology of GP remains unclear, its specific symptom of a false lump sensation in the throat without physical obstruction raises the possibility of alterations in brain networks responsible for somatosensory and emotion processing in patients with GP. To address this possibility, we investigated resting-state functional connectivity (rsFC) in 31 patients with GP and 24 healthy individuals using resting-state functional magnetic resonance imaging. Considering its significance in somatosensory and emotional functions, we focused on rsFC in the subregions of the thalamus. We found significantly decreased rsFC between the right caudal temporal thalamus (rcTtha) and the midcingulate cortex (MCC) as well as significantly decreased rsFC between the right rostral temporal thalamus (rrTtha) and the left cerebellum in the patients with GP. Additionally, within the patient group, the abnormalities in rsFC between the rcTtha and the MCC were correlated with the severity of somatization symptoms but not with depression and anxiety. These findings suggest alterations in the rsFC of thalamic subregions in patients with GP, shedding light on the pathogenesis of GP and potentially leading to improved diagnosis and treatment approaches for the condition.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex influences whether hippocampal volumes mediate the relationship between depression and cognition in older adults without dementia: A UK Biobank study. 性别是否会影响海马体体积在无痴呆症老年人的抑郁与认知之间的关系：英国生物数据库研究。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-11 DOI: 10.1007/s11682-024-00930-6

Nancy E Ortega, Vahan Aslanyan, Judy Pa

{"title":"Sex influences whether hippocampal volumes mediate the relationship between depression and cognition in older adults without dementia: A UK Biobank study.","authors":"Nancy E Ortega, Vahan Aslanyan, Judy Pa","doi":"10.1007/s11682-024-00930-6","DOIUrl":"https://doi.org/10.1007/s11682-024-00930-6","url":null,"abstract":"Depression is a modifiable risk factor for dementia; however, it remains unclear whether there are sex differences in how depression affects dementia risk. To better understand sex-specific differences in how depression confers risk of dementia, the link between depression, hippocampal volumes, and cognition was evaluated in a sample of older adults without dementia from the UK Biobank cohort. A total of 18,220 participants (women n = 9,474; men n = 8,746) were selected based on completion of the Patient Health Questionnaire (PHQ-9), structural MRI, and cognitive assessments. Causal mediation analyses were used to evaluate if the relationship between depression and cognition is mediated by the hippocampus differently by sex. Women reported greater depression severity than men. Hippocampal volumes were found to mediate the relationship between depression severity and fluid intelligence only in women. Upon categorization of the depression symptoms as either cognitive/affective or somatic, the mediation effect of the hippocampus was seen for both cognitive/affective and somatic symptom severity in women for fluid intelligence. These results offer insight into the sex-specific pathways underlying the relationship between depression, hippocampal volumes, and cognition in older adults without dementia with a focus on the type of depression symptoms. This knowledge could aid in the development of sex-focused dementia prevention strategies and treatments.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graph theory-driven structural and functional connectivity analyses revealing regulatory mechanisms of brain network in patients with classic trigeminal neuralgia. 图论驱动的结构和功能连接分析揭示了典型三叉神经痛患者大脑网络的调控机制。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-10 DOI: 10.1007/s11682-024-00915-5

Zairan Wang, Zhimin Li, Gang Zhou, Jie Liu, Zongmao Zhao, Jun Gao, Yongning Li

{"title":"Graph theory-driven structural and functional connectivity analyses revealing regulatory mechanisms of brain network in patients with classic trigeminal neuralgia.","authors":"Zairan Wang, Zhimin Li, Gang Zhou, Jie Liu, Zongmao Zhao, Jun Gao, Yongning Li","doi":"10.1007/s11682-024-00915-5","DOIUrl":"https://doi.org/10.1007/s11682-024-00915-5","url":null,"abstract":"A specific regulatory mechanism underlying classical trigeminal neuralgia (cTN) remains unknown. The present study posits that the initiation and advancement of cTN may be attributed to a self-regulatory and compensatory mechanism within the brain's limbic system. A sample size of thirty-three patients diagnosed with cTN and twenty-one normal controls were recruited for this investigation. Functional magnetic resonance imaging data were collected from all participants. Graph-theoretic analysis was employed to identify abnormal nodes induced by cTN in the brain atlas, followed by determining the brain network function in conjunction with the outcomes of regional homogeneity (ReHo) and functional connectivity (FC). During data processing, relatively strict thresholds were set for all corrections. The findings indicated that the discrepancy in small-worldness characteristics between the two cohorts primarily stemmed from the characteristic path length. Additionally, there was an overlap between brain regions exhibiting markedly reduced node efficiency in cTN patients and those exhibiting markedly reduced ReHo signal. The FC analysis of the whole brain revealed nine brain regions with reduced connectivity in the cTN group, corresponding to brain regions with diminished node efficiency. Notably, most of these abnormal brain regions were located in the limbic system, providing evidence of the compensatory mechanism of the limbic system.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies. 帕金森病嗅觉功能障碍的微观结构相关性：弥散核磁共振成像研究的系统回顾。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-10-10 DOI: 10.1007/s11682-024-00934-2

Homa Seyedmirzaei, Pegah Rasoulian, Mohammadamin Parsaei, Majid Hamidi, Amin Ghanbari, Alireza Soltani Khaboushan, Farzad Fatehi, Arash Kamali, Houman Sotoudeh

{"title":"Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies.","authors":"Homa Seyedmirzaei, Pegah Rasoulian, Mohammadamin Parsaei, Majid Hamidi, Amin Ghanbari, Alireza Soltani Khaboushan, Farzad Fatehi, Arash Kamali, Houman Sotoudeh","doi":"10.1007/s11682-024-00934-2","DOIUrl":"https://doi.org/10.1007/s11682-024-00934-2","url":null,"abstract":"Olfactory dysfunction (OD) is a non-motor symptom of Parkinson's Disease, affecting 75-95% of the patients. This symptom usually emerges before the clinical diagnosis, and patients with OD present with more severe forms of PD and need higher doses of therapy. It remains unknown whether OD is just a mere non-motor symptom or if it is a part of a series of pathological changes in different brain regions of the affected patients. We performed a systematic review to find the microstructural correlates of OD in people with PD. The systematic search in PubMed, Scopus, Embase, and Web of Science yielded ten eligible studies. Assessments in most included studies were inconclusive. However, we found variable brain regions and tracts associated with OD. The most repeated areas included the primary olfactory cortex, gyrus rectus, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, corticospinal tract, uncinate fasciculus, cingulum, and cerebellar peduncle. Despite some limitations, we pointed out the microstructural correlates of OD, which were also present in areas other than the olfactory system. These findings imply that OD might be a manifestation of an unknown, greater pathology in the brain of patients with PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0