Brain Imaging and Behavior最新文献

{"title":"Altered functional connectivity within and between resting-state networks in ulcerative colitis.","authors":"Yanjun Ren, Kaizhong Xue, Huijuan Xu, Lijie Hao, Quchuan Zhao, Tianyu Chi, Hongwei Yang, Xiaojing Zhao, Defeng Tian, Huihong Zhai, Jie Lu","doi":"10.1007/s11682-025-01001-0","DOIUrl":"https://doi.org/10.1007/s11682-025-01001-0","url":null,"abstract":"<p><p>Patients with ulcerative colitis (UC) often exhibit affective disorders, such as depression and anxiety. The underlying neurological mechanisms of these symptoms, however, remain poorly understood. This study aimed to explore alterations in functional connectivity (FC) both within and between resting-state networks (RSNs) in individuals with ulcerative colitis. Twelve meaningful RSNs were identified from 22 ulcerative colitis patients and 23 healthy controls using independent component analysis of functional magnetic resonance imaging data. Correlation analyses were performed between clinical indices, neuropsychological assessments and neuroimaging data. Compared with healthy controls, UC patients showed increased intranetwork FC, mainly located in the right temporal pole, orbitofrontal cortex, and left superior temporal and Rolandic opercular cortices within the auditory network. Increased intranetwork FC in the Rolandic opercular cortex was also observed in UC patients during remission phase, while no significant alterations were detected in patients with active-phase UC. In addition, UC patients exhibited increased connectivity between the dorsal attention and the left frontoparietal network, as well as between the anterior default mode network and the posterior default mode network, with distinct patterns of internetwork connectivity observed across different clinical phases. No significant correlations were found between altered brain regions and psychological scales in UC patients. These findings imply that UC patients may undergo functional network alterations, affecting both intranetwork connectivity within RSNs and internetwork connectivity between RSNs.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients.","authors":"Lijun Kang, Qian Gong, Wei Wang, Zhaowen Nie, Lihua Yao, Dan Xiang, Ning Tu, Hongyan Feng, Huiling Wang, Gaohua Wang, Lihong Bu, Zhongchun Liu","doi":"10.1007/s11682-025-00983-1","DOIUrl":"https://doi.org/10.1007/s11682-025-00983-1","url":null,"abstract":"<p><p>Major depressive disorder (MDD) exhibits a moderate degree of heritability and shares common influences with early adverse life events, as well as being associated with inconsistent changes in cerebral blood flow (CBF). Here, we investigated whether MDD polygenic risk score (PRS) and emotional neglect influences alterations in CBF. We collected blood and ASL from MDD patients. Emotional neglect (EN) assessment was performed using the Childhood Trauma Questionnaire. We calculated PRS for MDD based the MDD GWAS result in Asian populations. Subsequently, we examined the interaction between PRS for MDD and EN on CBF. Finally, 174 participated in statistical analysis. After adjusting for confounding factors, there was a significant main effect of PRS on left dorsolateral superior frontal gyrus, while the main effect of EN was not significantly (P < 0.001, GRF corrected). And significant interactive effect was found between PRS of MDD and EN on precuneus CBF (P < 0.001, GRF corrected). In MDD, high polygenic risk independently influenced changes in left dorsolateral superior frontal gyrus CBF, while EN plays a role in individuals with a higher genetic risk for MDD. Our study indicates the need to consider the combined effects of genetic risk and early adverse events on alterations in brain structure in the occurrence of MDD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neurobiology of motivational anhedonia in patients with depression.","authors":"Sigrid Breit, Niklaus Denier, Nicolas Mertse, Sebastian Walther, Leila M Soravia, Andrea Federspiel, Roland Wiest, Tobias Bracht","doi":"10.1007/s11682-025-00999-7","DOIUrl":"https://doi.org/10.1007/s11682-025-00999-7","url":null,"abstract":"<p><p>Anhedonia is a core feature of depression. It contains a consummatory and a motivational aspect. Whilst much neuroimaging research in patients with depression focused on the consummatory aspect of anhedonia, less is known about its motivational aspect. This study aimed to explore the neurobiology of networks related to motivational anhedonia. Thirty-eight patients with major depressive disorder (MDD) and 19 healthy controls underwent diffusion-weighted and resting state functional magnetic resonance imaging (rs-fMRI). For assessment of motivational anhedonia, we summed the values of the CORE non-interactiveness score, and the items 1 (hopelessness) and 7 (work and activities) of the Hamilton Depression Rating Scale. Whole-brain voxel-wise statistical analysis of fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics (TBSS). Additionally, we performed a whole-brain comparison of integrated local correlation of rs-fMRI signal (LCOR), to investigate regional functional differences between patients and healthy controls. Whole brain correlations between motivational anhedonia and measures of structural and functional connectivity (FA, and LCOR) were calculated. TBSS-analyses revealed reduced FA in the left superior longitudinal fasciculus (SLF) in patients with MDD. LCOR was reduced in patients with depression in an adjacent cluster localized in bilateral precunei. Within patients, there was a positive correlation between motivational anhedonia and LCOR in the precunei and a negative correlation in bilateral sensorimotor areas. FA-values did not show significant correlations. These findings suggest that motivational anhedonia in depression is linked to alterations of functional connectivity within bilateral precunei. Observed white matter microstructural alterations in the SLF do not show such an association.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients.","authors":"Jiahui Tang, Yali Zhao, Yu Chen, Yuan Yang, Zhenxiang Gong, Zehui Li, Min Zhang, Jing Zhang","doi":"10.1007/s11682-025-00991-1","DOIUrl":"https://doi.org/10.1007/s11682-025-00991-1","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between plasma uric acid levels and white matter microstructural alterations in amyotrophic lateral sclerosis (ALS) patients and to explore the potential mediating role of white matter microstructural alterations in the protective effect of plasma uric acid on cognitive function in ALS patients.</p><p><strong>Methods: </strong>73 right-handed ALS patients were recruited for this study. Plasma uric acid levels were measured, diffusion tensor imaging scans were performed to assess white matter integrity, and cognition was evaluated using the Edinburgh Cognitive and Behavioral Screen. The relationships among plasma uric acid, white matter integrity, and cognitive function were examined through multivariate linear regression analysis. Additionally, mediation analysis was performed to investigate whether white matter integrity mediated the relationship between uric acid levels and cognitive function.</p><p><strong>Results: </strong>The findings revealed a positive correlation between plasma uric acid levels and extensive preservation of white matter microstructure in various regions, including the fornix, cerebellar, internal capsule, frontotemporal and frontooccipital lobe bundles among ALS patients. Mediation analysis indicated that fractional anisotropy in the hippocampal portion of the cingulum fully mediated the effects of plasma uric acid levels on executive function in ALS patients.</p><p><strong>Interpretation: </strong>Our results suggested that elevated plasma uric acid may preserve the integrity of white matter microstructure in ALS patients. Furthermore, we have identified evidence supporting the mediating influence of the hippocampal portion of the cingulum in linking plasma uric acid levels to cognitive function among ALS patients.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis.","authors":"Tingting Zhu, Jing Chen, Yanting Du, Tongyue Li, Xize Jia, Yating Lv","doi":"10.1007/s11682-025-00977-z","DOIUrl":"https://doi.org/10.1007/s11682-025-00977-z","url":null,"abstract":"<p><p>This study aims to unravel the consistent abnormalities in functional connectivity (FC) with the primary motor cortex (M1) for post-stroke motor dysfunctions and the dynamic shifts of FC across distinct phases (acute/subacute/chronic) following stroke onset. Eleven studies with 269 stroke patients and 257 healthy controls (HCs) were included after screening articles in PubMed, Web of Science, and Embase. Voxel-wise meta-analysis and subgroup analysis on three phases after stroke onset were applied using the anisotropic effect size-signed differential mapping toolbox. Additionally, a M1-seeded FC analysis from an independent dataset with 29 stroke patients and 40 HCs was applied to validate the results of the meta-analyses. The abnormal connectivity with M1 in patients with post-stroke motor dysfunctions extended beyond motor-related regions to non-motor domains. A consistent interhemispheric connectivity reduction between M1 and motor-related regions emerged as a hallmark, persisting across different phases after stroke onset. These alterations were largely replicable through validation analysis. Our findings indicated the imbalance of connectivity in patients with post-stroke motor dysfunctions.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing morphological fingerprints in perinatal brains using quasi-conformal mapping: occurrence and neurodevelopmental implications.","authors":"Ying Wang, Boyang Wang, Dalin Zhu, Weihao Zheng, Yucen Sheng","doi":"10.1007/s11682-025-00998-8","DOIUrl":"https://doi.org/10.1007/s11682-025-00998-8","url":null,"abstract":"<p><p>The morphological fingerprint in the brain is capable of identifying the uniqueness of an individual. However, whether such individual patterns are present in perinatal brains, and which morphological attributes or cortical regions better characterize the individual differences of neonates remain unclear. In this study, we proposed a deep learning framework that projected three-dimensional spherical meshes of three morphological features (i.e., cortical thickness, mean curvature, and sulcal depth) onto two-dimensional planes through quasi-conformal mapping, and employed the ResNet18 and contrastive learning for individual identification. We used the cross-sectional structural MRI data of 461 infants, incorporating with data augmentation, to train the model and fine-tuned the parameters based on 41 infants who had longitudinal scans. The model was validated on a fold of 20 longitudinal scanned infant data, and remarkable Top1 and Top5 accuracies of 85.90% and 92.20% were achieved, respectively. The sensorimotor and visual cortices were recognized as the most contributive regions in individual identification. Moreover, morphological fingerprints successfully predicted the long-term development of cognition and behavior. Furthermore, the folding morphology demonstrated greater discriminative capability than the cortical thickness. These findings provided evidence for the emergence of morphological fingerprints in the brain at the beginning of the third trimester, which may hold promising implications for understanding the formation of individual uniqueness, and predicting long-term neurodevelopmental risks in the brain during early development.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cerebellar subregion functional connectivity and structure in patients with pediatric bipolar depression.","authors":"Yongming Tan, Hao Wang, Huifang Du, Yongjie Zhou, Mengqian Li, Laichang He","doi":"10.1007/s11682-025-00997-9","DOIUrl":"https://doi.org/10.1007/s11682-025-00997-9","url":null,"abstract":"<p><p>To explore the structural and functional changes of Cerebellar Subregion in patients with pediatric bipolar disorder (PBD) patients and its clinical significance by using multimodal magnetic resonance imaging, so as to further explore the specific role of the cerebellum in PBD. This study included 48 pediatric patients with bipolar disorder (PBD) in the depressive phase from the outpatient clinic of the Department of Psychosomatic Medicine of the First Affiliated Hospital of Nanchang University. 22 healthy controls (HCs) matched for gender, age, handedness and education level were chosen from the community as the control group. All subjects underwent 3.0T resting-state functional magnetic resonance imaging (rs-fMRI) scans and completed clinical scales, including the Hamilton Depression Scale (HAMD) and Young Mania Rating Scale (YMRS). The cerebellum was categorized into 34 distinct subregions (R17, L17) based on SUIT and designated as seed points to perform whole-brain functional connectivity (FC). Group differences in categorical variables were assessed using the chi-square test, while continuous variables were compared employing the two-sample t-test. Correlations between FC and clinical parameters were analyzed for differential brain intervals. Compared with HCs, PBD patients in the depressive phase showed reduced FC between the left cerebellar lobules I-IV and the occipital inferior lobe (Occipital_Inf_L), cerebellar vermis VIIIa, and VIIIb; decreased FC between cerebellar cerebellar vermis VI and the frontal inferior orbital gyrus (Frontal_Inf_Orb_L), as well as the right cerebellar Crus 1; reduced FC between the left cerebellar Crus I and the dentate nucleus; decreased FC between cerebellar vermis VIIIa and the left superior frontal gyrus; reduced FC between the right cerebellar lobule IX and the right lingual gyrus; lowered FC between the left dentate and the dorsolateral prefrontal cortex, and the left lingual gyrus; FC between the left fastigial nucleus and the right cerebellar X decreased. Depressive phase of PBD patients exhibit altered functional connectivity within various subregions of the cerebellum, suggesting that the cerebellum is involved in central neural reorganization in PBD, which may be instructive for the understanding of central mechanisms and its future diagnostic and therapeutic target development.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between social network size and brain structure in older adults living with HIV.","authors":"Vinaya Hari, Nancy E Mayo, Marie-Josee Brouillette, MaryAnn Noonan, Lesley K Fellows","doi":"10.1007/s11682-025-00995-x","DOIUrl":"https://doi.org/10.1007/s11682-025-00995-x","url":null,"abstract":"<p><p>The social brain hypothesis suggests that primate brains evolved to manage social group complexities. While chronic HIV infection is associated with both structural brain changes and social exclusion, the possibility that social experience may contribute to brain changes has not been studied in this population. Here, we aimed to estimate the direction and strength of the relationship between gray matter volume and social network size in older people living with HIV in Canada. Fifty-eight HIV + participants (3 women) from the Positive Brain Health Now cohort underwent structural brain imaging and reported the size of their social network. We tested the relationship between social network size and gray matter volume in key brain regions previously identified in healthy older adults. Negative correlations were observed between social network size and gray matter volume in all regions of interest, adjusting for age, education, and total intracranial volume. The strongest correlation was in the left anterior cingulate cortex. We found evidence that social network size is related to gray matter volume in brain regions involved in social behavior among older people, mostly men, with longstanding HIV infection. However, the direction of this effect was opposite to that predicted. This echoes some previous work in healthy male samples. These findings suggest the need to consider social as well as biological variables in studying the brain impacts of living with HIV. Further work is needed to clarify which social variables have the greatest influence, and how they affect the brain.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity.","authors":"Daniel H Lench, Aaron Embry, Niloufar Malakouti, Nathan DeTurk, Gonzalo J Revuelta","doi":"10.1007/s11682-025-00996-w","DOIUrl":"https://doi.org/10.1007/s11682-025-00996-w","url":null,"abstract":"<p><p>Freezing of gait (FOG) in individuals with Parkinson's Disease is associated with a loss of gait automaticity. This loss of automaticity is demonstrated by worsening gait performance while dual tasking. Functional connectivity between the cerebellar vermis and cortex have previously been associated with spatiotemporal measures of gait in PD. The objective of this study was to determine whether this corticocerebellar connectivity is associated with gait automaticity as measured by dual task interference in PD FOG. 55 participants with PD were recruited (38 FOG, 17 non-FOG controls) to undergo a resting-state functional magnetic resonance imaging scan. Gait automaticity was quantified using spatiotemporal metrics from single and dual task time up and go trials. FOG participants demonstrated shorter step length and gait velocity compared to non-FOG PD controls. A trend toward greater dual task interference of step length in the FOG group was found. Using a seed-based connectivity approach we observed that FOG participants have greater vermis connectivity than non-FOG PD participants to several cortical regions including the superior parietal lobe, supplemental motor area, precentral gyrus and posterior cingulate (voxel threshold p < 0.01, cluster FWE corrected p < 0.05). Meanwhile, vermis connectivity to the occipital cortex was reduced in FOG participants relative to non-FOG controls. Dual task interference of step length among the FOG group correlated with the degree of vermis connectivity to the sensorimotor cortex and superior parietal cortex (voxel threshold p < 0.01, cluster FWE corrected p < 0.05). We conclude that increased corticocerebellar connectivity may be associated with loss of gait automaticity in individuals with PD FOG.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the neural network correlates of apathy, disinhibition, and executive dysfunction in active-duty United States Special Operations Forces.","authors":"Natalie Gilmore, Isabella R McKinney, Chieh-En J Tseng, Douglas N Greve, Chiara Maffei, Brian C Healy, Nicole R Zürcher, Jacob M Hooker, Samantha L Tromly, Daniel P Perl, Kristen Dams-O'Connor, Christine L Mac Donald, Brian L Edlow, Yelena G Bodien","doi":"10.1007/s11682-025-00980-4","DOIUrl":"https://doi.org/10.1007/s11682-025-00980-4","url":null,"abstract":"<p><p>United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 29 male active-duty SOF with mean (SD) 17(4) years of service, we tested whether self-reported symptoms of apathy, disinhibition, and executive dysfunction measured by the Frontal Systems Behavior Scale, were related to functional magnetic resonance imaging and positron emission tomography biomarkers (translocator protein and tau) of the limbic, salience, and executive control networks. Higher disinhibition was associated with lower functional connectivity and higher tau signal within the salience network, though both associations diminished with age. These findings provide the basis for future multimodal studies to elucidate the relationship between neurobehavioral symptoms and neuroimaging biomarkers in the context of repeated blast exposure.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}