Brain Imaging and Behavior最新文献

Fatigue, monocyte activation, and degree centrality of the thalamus in post-menopausal women living with HIV. 疲劳，单核细胞活化，和程度中心性的丘脑在绝经后妇女艾滋病毒携带者。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-16 DOI: 10.1007/s11682-025-01028-3

Kaitlyn Dillon, Judith Lobo, Suresh Pallikkuth, Bonnie Levin, Roger McIntosh

引用次数: 0

Cerebellar large-scale network connectivity in Parkinson's disease: associations with emotion, cognition, and aging effects. 帕金森病的小脑大规模网络连接：与情绪、认知和衰老效应的关联

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-06 DOI: 10.1007/s11682-025-01030-9

Chentao He, Zhenzhen Chen, Mengfei Cai, Piao Zhang, Hao Li, Xi Chen, Qi Qi, Rui Yang, Yan Li, Zaiyi Liu, Lijuan Wang, Yuhu Zhang

{"title":"Cerebellar large-scale network connectivity in Parkinson's disease: associations with emotion, cognition, and aging effects.","authors":"Chentao He, Zhenzhen Chen, Mengfei Cai, Piao Zhang, Hao Li, Xi Chen, Qi Qi, Rui Yang, Yan Li, Zaiyi Liu, Lijuan Wang, Yuhu Zhang","doi":"10.1007/s11682-025-01030-9","DOIUrl":"https://doi.org/10.1007/s11682-025-01030-9","url":null,"abstract":"Emerging evidence highlights the cerebellum's involvement in Parkinson's disease (PD), yet its intrinsic functional connectivity with cortical-subcortical networks remains largely unexplored. This study aims to investigate cerebellar functional network alterations in PD and their associations with motor, cognitive, and emotional symptoms, as well as age-related effects. 82 participants with PD (PwPD) and 38 healthy controls (HCs) underwent structural and resting-state functional MRI scans. We conducted volumetric analysis in the cerebellum and examined the involvement of cerebellar functional networks in PD, both within-network and between-network connections regarding cortical-subcortical large-scale networks. Additionally, we explored correlations with motor, cognitive, and emotional symptoms, as well as age-related associations in PwPD. No significant differences in cerebellar volume were observed between PwPD and HCs. PwPD exhibited reduced functional connectivity within the cerebellar network and between the cerebellum (CER) and the salience network (SN) (P < 0.001). Decreased CER-SN connectivity correlated with lower MoCA scores and higher HAMD scores, indicating associations with cognitive impairment and depressive symptoms. Additionally, CER-MTL (medial temporal lobe) connectivity positively correlated with both HAMD and HAMA scores in PwPD. Age-related differences in CER-SN connectivity were significant between PwPD and HCs (P = 0.008). Our study suggests the involvement of cerebellar large-scale functional network connectivity in PD, emphasizing the role of cerebellar functional networks in the emotional and cognitive aspects of PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffusion basis spectrum imaging of white matter in schizophrenia and bipolar disorder. 精神分裂症和双相情感障碍白质扩散基谱成像。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-06 DOI: 10.1007/s11682-025-01021-w

Daniel Mamah, Aakash Patel, ShingShiun Chen, Yong Wang, Qing Wang

{"title":"Diffusion basis spectrum imaging of white matter in schizophrenia and bipolar disorder.","authors":"Daniel Mamah, Aakash Patel, ShingShiun Chen, Yong Wang, Qing Wang","doi":"10.1007/s11682-025-01021-w","DOIUrl":"10.1007/s11682-025-01021-w","url":null,"abstract":"Multiple studies point to the role of neuroinflammation in the pathophysiology of schizophrenia (SCZ), however, there have been few in vivo tools for imaging brain inflammation. Diffusion basis spectrum imaging (DBSI) is an advanced diffusion-based MRI method developed to quantitatively assess microstructural alternations relating to neuroinflammation, axonal fiber, and other white matter (WM) pathologies. We acquired one-hour-long high-directional diffusion MRI data from young control (CON, n = 27), schizophrenia (SCZ, n = 21), and bipolar disorder (BPD, n = 21) participants aged 18-30. We applied Tract-based Spatial Statistics (TBSS) to allow whole-brain WM analyses and compare DBSI-derived isotropic and anisotropic diffusion measures between groups. Clinical relationships of DBSI metrics with clinical symptoms were assessed across SCZ and control participants. In SCZ participants, we found a generalized increase in DBSI-derived cellularity (a putative marker of neuroinflammation), a decrease in restricted fiber fraction (a putative marker of apparent axonal density), and an increase in extra-axonal water (a putative marker of vasogenic edema) across several WM tracts. There were only minimal WM abnormalities noted in BPD, mainly in regions of the corpus callosum (increase in DTI-derived RD and extra-axonal water). DBSI metrics showed significant partial correlations with psychosis and mood symptoms across groups. Our findings suggest that SCZ involves generalized white matter neuroinflammation, decreased fiber density, and demyelination, which is not seen in bipolar disorder. Larger studies are needed to identify medication-related effects. DBSI metrics could help identify high-risk groups requiring early interventions to prevent the onset of psychosis and improve outcomes.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining functional, structural, and morphological networks for multimodal classification of developing autistic brains. 结合功能、结构和形态网络对发育中的自闭症大脑进行多模态分类。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-04 DOI: 10.1007/s11682-025-01026-5

Changchun He, Jesus M Cortes, Yi Ding, Xiaolong Shan, Maoyang Zou, Heng Chen, Huafu Chen, Xianmin Wang, Xujun Duan

{"title":"Combining functional, structural, and morphological networks for multimodal classification of developing autistic brains.","authors":"Changchun He, Jesus M Cortes, Yi Ding, Xiaolong Shan, Maoyang Zou, Heng Chen, Huafu Chen, Xianmin Wang, Xujun Duan","doi":"10.1007/s11682-025-01026-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01026-5","url":null,"abstract":"Accumulating neuroimaging evidence suggests that abnormal functional and structural brain connectivity plays a cardinal role in the pathophysiology of autism spectrum disorder (ASD). Here, we constructed brain networks of functional, structural, and morphological connectivity using data from functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and structural magnetic resonance imaging (sMRI), respectively. The neuroimaging data from a cohort of 50 individuals with ASD and 47 age-, gender- and handedness-matched TDC (age range: 5-18 years) were selected from the Autism Brain Image Data Exchange database. The combination of the fMRI, sMRI and DTI modalities connectivity features resulted in a classification accuracy of 82.69% for differentiating individuals with ASD from TDC. This accuracy surpassed that of any single modality or combination of fMRI and DTI modalities previously examined. Among the fMRI, sMRI and DTI modalities, the most distinguishing connectivity features were observed in the temporal, parietal, and occipital lobes from the DTI modality, the prefrontal and parietal lobes from the fMRI modality, and the temporal lobe from the sMRI modality. In addition, we also found that these distinguishing connectivity features can predict abnormal social interaction behaviours in ASD. These results highlight the complementary information provided by multimodal approaches, further emphasizing the pivotal role of multimodal connectivity patterns in unravelling the intricate mechanisms involved in the pathophysiology of ASD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review. 卒中后认知障碍的静息状态功能连接改变：一项系统综述。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-04 DOI: 10.1007/s11682-025-01013-w

Elena Sagues, Francisco Alfaro, Ramón Ramos-Rodríguez, Natalia García-Casares

{"title":"Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review.","authors":"Elena Sagues, Francisco Alfaro, Ramón Ramos-Rodríguez, Natalia García-Casares","doi":"10.1007/s11682-025-01013-w","DOIUrl":"https://doi.org/10.1007/s11682-025-01013-w","url":null,"abstract":"Post-stroke cognitive impairment is a common and highly disabling multi-domain cognitive decline with unclear pathophysiological mechanisms. Its extent may be predicted by functional neuroimaging techniques, which could enhance our understanding of its underlying pathophysiology. Synthesize the state-of-the-art knowledge on resting-state functional magnetic resonance imaging findings in post-stroke cognitive impairment, their correlation with cognitive performance and the secondary compensatory connectivity changes. We performed a qualitative systematic literature review of reported data of resting-state functional magnetic resonance imaging abnormalities in post-stroke cognitive impairment, consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2024. We selected 23 studies. They reported several key brain areas and network abnormalities associated with post-stroke cognitive impairment compared to controls and non-demented patients. The main areas with decreased functional connectivity were the medial prefrontal cortex, the inferior frontal gyrus, the posterior and anterior cingulate cortex, the precuneus and the hippocampus. The principal network altered was the default mode network, which includes the majority of the brain structures previously mentioned. Additionally, increased functional connectivity in other contralesionally areas may represent maladaptive or compensatory changes post-stroke. Resting-state functional magnetic resonance imaging is a promising tool for studying functional changes associated with post-stroke cognitive impairment. It may enhance our understanding of its pathophysiology and improve selection of suitable period or candidates for cognitive rehabilitation.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered perfusion in the locus coeruleus of patients with chronic migraine: a pilot 3D-PCASL study. 慢性偏头痛患者蓝斑血流灌注改变：一项3D-PCASL试验研究

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-03 DOI: 10.1007/s11682-025-01020-x

Jianmei Xiong, Mengqi Liu, Xin Li, Zhiye Chen

{"title":"Altered perfusion in the locus coeruleus of patients with chronic migraine: a pilot 3D-PCASL study.","authors":"Jianmei Xiong, Mengqi Liu, Xin Li, Zhiye Chen","doi":"10.1007/s11682-025-01020-x","DOIUrl":"https://doi.org/10.1007/s11682-025-01020-x","url":null,"abstract":"Numerous studies have demonstrated that the locus coeruleus (LC) is activated by acute, nociceptive pain and plays an important role in the management of chronic pain. The purpose of this study was to assess the morphology and cerebral blood flow (CBF) changes in the LC of chronic migraine (CM) patients and explore the associations between these changes and the clinical features of these patients via three-dimensional pseudocontinuous arterial spin labelling (3D PCASL) in order to better elucidate the role of the LC in the pathophysiology of CM. Thirteen patients diagnosed with CM at the Department of Neurology, Hainan Hospital of PLA General Hospital, from May 2020 to June 2021 were prospectively included, and fifteen age- and sex-matched normal controls (NCs) were enrolled. All participants underwent psychoneurological assessments and brain structural and 3D PCASL MRI examinations. Brain region volume and CBF alterations were assessed, their associations with clinical scores were analysed, and receiver operating characteristic (ROC) curve analysis was conducted to determine the variables that best differentiated between the groups. No significant differences were found in the total volume of the LC between CM patients and NCs (P > 0.05). Compared with that in the NCs, the CBF of the bilateral LCs was lower in CM patients; the difference on the right side was statistically significant (P = 0.031). Correlation analysis revealed a negative correlation between the CBF of the LC and disease duration (in years). ROC curve analysis revealed that the area under the curve of the CBF of the right LC was 0.749 (95% CI 0.563-0.935), and the optimal cut-off value, sensitivity, and specificity in distinguishing CM patients from NCs were 49.67 ml/100 mg/min, 0.53 and 0.92, respectively. Hypoperfusion of the bilateral LC was observed in CM patients and contributes to the understanding of the pathogenesis of CM. 3D PCASL could serve as a useful tool for diagnosing and assessing CM.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hidden burden: cerebral small vessel disease and cognitive reappraisal failure in memory clinic older adults. 隐性负担：记忆门诊老年人脑血管疾病和认知重评失败。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-03 DOI: 10.1007/s11682-025-01018-5

Renren Li, Weixin Xiao, Zengmai Xie, Jing Ma, Xiaoran Zheng, Jiaxin Yan, Xiaochen Zhang, Zhiyu Nie, Yunxia Li

{"title":"The hidden burden: cerebral small vessel disease and cognitive reappraisal failure in memory clinic older adults.","authors":"Renren Li, Weixin Xiao, Zengmai Xie, Jing Ma, Xiaoran Zheng, Jiaxin Yan, Xiaochen Zhang, Zhiyu Nie, Yunxia Li","doi":"10.1007/s11682-025-01018-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01018-5","url":null,"abstract":"Emotion regulation is a vital life skill, and cognitive reappraisal (CR) is the most effective emotion regulation strategy, which plays a key role in healthy aging. In memory clinic patients, problems with emotion regulation difficulties and cognitive impairment are very common, often accompanied by signs of cerebral small vessel disease (CSVD) on their magnetic resonance imaging (MRI). Is there a correlation among cognitive reappraisal failure, cognitive impairment, and CSVD in these older adults? This study aims to investigate the question. A standardized emotion regulation task was used to measure CR ability. A total of 170 older adults were included in statistical analysis, of which 78 were considered as cognitive reappraisal failure (CR-Failure). All participants completed the emotion regulation task, neuropsychiatric assessments, and MRI scans, with traditional CSVD markers being evaluated. Our analysis indicated that CR ability is negatively correlated with scores on the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Additionally, logical memory and executive function are significant factors in CR utilization. A higher burden of CSVD or presence of cognitive impairment is an independent risk factor for cognitive reappraisal failure in memory clinic older adults. Furthermore, cognitive impairment significantly mediates the relationship between greater CSVD burden and CR failure.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter microstructural alterations and brain metabolism distributions in Parkinson's disease. 帕金森病白质微结构改变与脑代谢分布。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-03 DOI: 10.1007/s11682-025-01023-8

Mengjiao Wang, Yansong Liu, Wei Han, Yifeng Yang, Yuying Jiao, Yujie Hu, Yang Yang, Linhan Zhang, Yangyang Wang, Peng Fu, Changjiu Zhao

{"title":"White matter microstructural alterations and brain metabolism distributions in Parkinson's disease.","authors":"Mengjiao Wang, Yansong Liu, Wei Han, Yifeng Yang, Yuying Jiao, Yujie Hu, Yang Yang, Linhan Zhang, Yangyang Wang, Peng Fu, Changjiu Zhao","doi":"10.1007/s11682-025-01023-8","DOIUrl":"https://doi.org/10.1007/s11682-025-01023-8","url":null,"abstract":"This study aimed to use simultaneous 18F-FDG PET/MRI based on Automated Fiber Quantification (AFQ) to determine whether there is a relationship between white matter microstructure changes and glucose metabolism distribution in PD. The study involved 38 subjects, including 23 parkinson's disease (PD) patients and 15 age and sex-matched healthy controls (HC). Primary clinical data and cognitive assessments were collected. All subjects underwent a simultaneous 18F-FDG PET/MRI scan. AFQ was utilized to calculate tract-wise diffusion properties of 20 major white matter tracts. PD patients showed reduced mean Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores compared to HC subjects (P < 0.05). PD patients showed higher mean diffusivity (MD) (P = 0.047) and axial diffusivity (AD) (P = 0.02) along the right corticospinal tract (CST) compared to HC. The microstructural change of CST was mainly located in the parietal part (node 67-100). Compared to HC, PD patients had FDG hypermetabolism in the right paracentral lobule (P = 0.0204) and bilateral putamen (left: P = 0.0075; right: P = 0.0155) and hypometabolism in the right calcarine (P = 0.0489). Hypermetabolism was found in the right paracentral lobule, which connects with the cortex of the right CST, and positively correlated with MD (r = 0.612, P < 0.001) and AD (r = 0.516, P < 0.001). We observed microstructural changes and glucose metabolism distribution characteristics in PD patients. These results may provide imaging evidence for studying the pathology of PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of glucocorticoid therapy on brain white matter microstructure in thyroid-associated ophthalmopathy: a longitudinal diffusion kurtosis imaging study. 糖皮质激素治疗对甲状腺相关性眼病脑白质微结构的影响：纵向扩散峰度成像研究。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-06-01 DOI: 10.1007/s11682-025-01025-6

Qian Wu, Jin-Ling Lu, Jiang Zhou, Xiong-Ying Pu, Huan-Huan Chen, Fei-Yun Wu, Xiao-Quan Xu, Hao Hu

{"title":"Effect of glucocorticoid therapy on brain white matter microstructure in thyroid-associated ophthalmopathy: a longitudinal diffusion kurtosis imaging study.","authors":"Qian Wu, Jin-Ling Lu, Jiang Zhou, Xiong-Ying Pu, Huan-Huan Chen, Fei-Yun Wu, Xiao-Quan Xu, Hao Hu","doi":"10.1007/s11682-025-01025-6","DOIUrl":"https://doi.org/10.1007/s11682-025-01025-6","url":null,"abstract":"To investigate the changes in brain white matter microstructure in patients with thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid therapy using diffusion kurtosis imaging (DKI) with tract-based spatial statistics (TBSS) method. Twenty TAO patients and 20 healthy controls were enrolled for clinical and magnetic resonance imaging (MRI) examinations. All patients had intravenous glucocorticoid therapy, followed by MRI scans and clinical assessments three months after the treatment ended. TBSS was used to evaluate the mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), kurtosis fractional anisotropy, fractional anisotropy (FA) and mean diffusion of brain white matter. At baseline, TAO patients showed significantly decreased MK, AK, RK and FA in extensive white matter tracts compared to controls. After therapy, increased MK and AK were observed in comparison to the pre-therapy cohort. However, post-therapy TAO patients still exhibited reduced RK in partial white matter tracts compared to controls. RK values in left posterior thalamic radiation (PTR) showed a negative correlation with CAS in pre-therapy TAO patients. Meanwhile, RK values in left PTR were positively correlated with quality of life scores for visual functioning, and RK values in left anterior corona radiata were negatively correlated with anxiety scores in post-therapy TAO patients. Our findings suggested that TAO could lead to white matter deficits in the visual, cognitive, and emotional brain areas, which were partially restored after treatment.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White matter microstructural and cognitive function changes in bipolar depression patients with suicidal ideation. 自杀意念双相抑郁症患者脑白质微结构及认知功能改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2025-05-31 DOI: 10.1007/s11682-025-01019-4

Junfan Liang, Rui Fan, Xinyin Guo, Hua Liu, Xuehua Li, Jixiang Yuan, Kezhi Liu, Xuemei Liang, Bo Xiang

{"title":"White matter microstructural and cognitive function changes in bipolar depression patients with suicidal ideation.","authors":"Junfan Liang, Rui Fan, Xinyin Guo, Hua Liu, Xuehua Li, Jixiang Yuan, Kezhi Liu, Xuemei Liang, Bo Xiang","doi":"10.1007/s11682-025-01019-4","DOIUrl":"https://doi.org/10.1007/s11682-025-01019-4","url":null,"abstract":"The pathophysiological mechanisms underlying suicidal ideation and decreased cognitive function in bipolar depression remain elusive. This study sought to elucidate the potential neuroanatomical basis of these phenomena using diffusion tensor imaging (DTI). 40 patients experiencing bipolar depressive episodes were enrolled, comprising 20 individuals with suicidal ideation (BDSI +), 20 without suicidal ideation (BDSI-), and 20 healthy controls (HCs), all of whom underwent DTI scanning. Clinical assessments primarily utilized the Beck Scale for Suicide Ideation (BSSI) and the Trail Making Test (TMT). Differences in fractional anisotropy (FA) values among the groups were compared using Tract-Based Spatial Statistics (TBSS). The identified differential brain regions were designated as regions of interest (ROIs), and covariance analysis was employed to compare the FA values among the three groups. Partial correlation analyses were conducted between the FA values in the ROIs and clinical symptoms. Differences in brain regions identified through TBSS were observed in the genu of the corpus callosum and the left anterior corona radiata (p < 0.05). Covariance analysis revealed that the BDSI + group exhibited significantly lower FA values in these regions compared to the HCs (p < 0.05). Partial correlation analyses showed that the FA values in the genu of corpus callosum were negatively correlated with BSSI scores (r = -0.592, p = 0.026) and TMT-A scores (r = -0.642, p = 0.013). The findings from this study suggest that alterations in the connectivity of the genu of the corpus callosum may relate to suicidal ideation and visuospatial function in patients with bipolar depression.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0