Brain Imaging and Behavior最新文献

{"title":"Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.","authors":"Tongfei Jiang, Xuejiao Yin, Liying Zhu, Guiling Wang, Fan Zhang, Jing Guo","doi":"10.1007/s11682-024-00949-9","DOIUrl":"https://doi.org/10.1007/s11682-024-00949-9","url":null,"abstract":"<p><p>Patients with insomnia disorder (ID) usually experience a greater burden of comorbid anxiety symptoms. However, the neural mechanism under the mutual relationship between ID and anxiety remains largely unclear. The meta-analysis aimed to explore the concordance and distinction of regional brain functional activity in patients with ID and those with generalized anxiety disorder (GAD) using coordinate-based activation likelihood estimation approach. Studies using resting-state regional homogeneity, amplitude of low-frequency fluctuations (ALFF), or fractional ALFF in patients with ID or GAD were included by searching multiple databases up to May 24, 2024. Using meta-analytic approach, 21 studies of ID vs. healthy controls (HC) and 16 studies of GAD vs. HC were included to illuminate the common and distinct patterns between the two disorders. Results showed that ID and GAD shared increased brain activities in the left posterior cingulate cortex and left precuneus, as well as decreased brain activity in the left medial prefrontal cortex. Additionally, compared with ID, GAD showed greater increased activities in the left superior frontal gyrus. Our study reveals both common and different activation patterns between ID and GAD, which may provide novel insights for understanding the neural basis of the two disorders and enlighten the possibility of the development of more targeted treatment strategies for ID and GAD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis.","authors":"Junquan Liang, Qiaoyun Yu, Limei Chen, Zhongxian Li, Yuchen Liu, Yidan Qiu, Huiting Guan, Rundong Tang, Luda Yan, Peng Zhou","doi":"10.1007/s11682-024-00946-y","DOIUrl":"https://doi.org/10.1007/s11682-024-00946-y","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is frequently comorbid with cognitive impairment, but it has not been paid enough attention, and its neuroanatomical characteristics have not been fully identified. Voxel-based morphometric (VBM) studies comparing gray matter (GM) abnormalities in COPD patients with healthy controls (HCs) were searched using 8 electronic databases from the inception to March 2023. Stereotactic data were extracted and tested for convergence and differences using the activation likelihood estimation (ALE) method. Moreover, based on the ALE results, a structural meta-analytic connectivity modeling (MACM) was conducted to explore the co-atrophy pattern in patients with COPD. Last, behavioral analysis was performed to assess the functional roles of the regions affected by COPD. In total, 11 studies on COPD with 949 participants were included. Voxel-based meta-analysis revealed significant GM abnormalities in the right postcentral gyrus (including inferior parietal lobule), left precentral gyrus, and left cingulate gyrus (including paracentral lobule) in patients with COPD compared with HCs. Further MACM analysis revealed a deeper co-atrophy pattern between the brain regions with abnormal GM structure and the insula in COPD patients. Behavioral analysis showed that the abnormal GM structure in the left cingulate gyrus (including paracentral lobule) was strongly associated with cognitive function, especially executive function. COPD comorbid with cognitive impairment has a specific neurostructural basis of GM structural abnormalities, which may also involve a deeper co-atrophy pattern between the insula. These findings enhance our understanding of the underlying neuropathogenesis and suggest potential imaging markers for cognitive impairment in COPD patients. PROSPERO registration number: CRD42022298722.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficient salience and default mode functional integration in high worry-proneness subject: a connectome-wide association study.","authors":"Youxue Zhang, Mingjun Duan, Hui He","doi":"10.1007/s11682-024-00951-1","DOIUrl":"https://doi.org/10.1007/s11682-024-00951-1","url":null,"abstract":"<p><p>Worry has been conceptualized as a relatively uncontrollable chain of thought that increases the risk of mental problems, such as anxiety disorders. Here, we examined the link between individual variation in the functional connectome and worry proneness, which remains unclear. A total of 32 high worry-proneness (HWP) subjects and 25 low worry-proneness (LWP) subjects were recruited. We conducted multivariate distance-based matrix regression to identify phenotypic relationships in high-dimensional brain resting-state functional connectivity data from HWP subjects. Multiple hub regions, including key brain nodes of the salience network (SN) and default mode network (DMN), were identified in HWP subjects. Follow-up analyses revealed that a high worry-proneness score was dominated by functional connectivity between the SN and the DMN. Moreover, HWP subjects showed hypoconnectivity between the cerebellum and the SN and DMN compared with LWP subjects. This cross-sectional study could not fully measure the causal relationships between changes in functional networks and worry proneness in healthy subjects. Functional changes in the cerebellum-cortical region might affect the modulation of external stimuli processing. Together, our results provide new insight into the role of key networks, including the SN, DMN and cerebellum, in understanding the potential mechanism underlying the high worry dimension in healthy subjects.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in motor network reorganization between patients with good and poor upper extremity impairment outcomes after stroke.","authors":"Ran Li, Yong Wang, Haimei Li, Jie Liu, Sujuan Liu","doi":"10.1007/s11682-024-00917-3","DOIUrl":"https://doi.org/10.1007/s11682-024-00917-3","url":null,"abstract":"<p><p>Changes in cortical excitability after stroke are closely associated with motor function recovery. This study aimed to clarify the motor network reorganization mechanisms corresponding to the different clinical outcomes of upper limb motor impairment in patients with subacute stroke. Motor function was assessed before rehabilitation (pre), after rehabilitation (post), and at the 1-year follow-up (follow-up) using the Fugl-Meyer assessment upper extremity scale. Further, resting-state functional magnetic resonance imaging (fMRI) data were collected in both pre- and post-conditions. Twenty patients with stroke were categorized into good and poor outcome groups based on motor impairments at the 1-year follow-up. Functional connections between motor-related regions of interest and the rest of the brain were subsequently calculated. Finally, the correlation between motor network reorganization and behavioral improvement at the 1-year follow-up was analyzed. The good outcome group exhibited a positive precondition motor function and continuous improvement, whereas the poor outcome group showed a weak precondition motor function and insignificant improvement. Contralesional hemisphere-related connections were found to be higher in the good outcome group pre-conditioning, with both groups showing minimal change post-conditioning, while no relationship with motor impairment was found. Long interhemispheric connections were decreased and increased in the good and poor outcome groups respectively, and were negatively correlated with motor impairment. Different motor network reorganizations during the subacute phase can influence the varying motor outcomes in the affected upper limb after stroke. These findings may serve as the theoretical basis for future neuromodulatory research.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural disruption in subjective cognitive decline and mild cognitive impairment.","authors":"Jie Song, Han Yang, Hailang Yan, Qian Lu, Lei Guo, Hui Zheng, Tianjiao Zhang, Bin Lin, Zhiyong Zhao, Chuan He, Ying Shen","doi":"10.1007/s11682-024-00933-3","DOIUrl":"https://doi.org/10.1007/s11682-024-00933-3","url":null,"abstract":"<p><p>Subjective cognitive decline (SCD) marks the initial stage in Alzheimer's disease continuum. Nonetheless, current research findings regarding brain structural changes in the SCD are inconsistent. In this study, 37 SCD patients, 28 mild cognitive impairment (MCI) patients, and 42 healthy controls (HC) were recruited to investigate structural alterations. Morphological and microstructural differences among the three groups were analyzed based on T1- and diffusion-weighted images, correlating them with neuropsychological assessments. Additionally, classification analysis was performed by using support vector machines (SVM) categorize participants into three groups based on MRI features. Both SCD and MCI showed decreased volume in left inferior parietal lobe (IPL) compared to HC, while SCD showed altered morphologies in the right inferior temporal gyrus (ITG), right insula and right amygdala, and microstructures in fiber tracts of the right ITG, lateral occipital cortex (LOC) and insula relative to MCI. Moreover, the volume in the left IPL, right LOC, right amygdala and diffusivity value in fiber tracts of right LOC were significantly correlated with cognitive functions across all subjects. The classification models achieved an accuracy of > 0.7 (AUC = 0.8) in distinguishing the three groups. Our findings suggest that SCD and MCI share similar atrophy in the IPL but show more differences in morphological and microstructural features of cortical-subcortical areas.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter microstructure damage measured by automated fiber quantification correlates with pain symptoms in lung cancer patients.","authors":"Li Ran, Jiang Liu, Xiaosong Lan, Xiaoyu Zhou, Yong Tan, Jing Zhang, Yu Tang, Lin Tang, Jiuquan Zhang, Daihong Liu","doi":"10.1007/s11682-024-00942-2","DOIUrl":"https://doi.org/10.1007/s11682-024-00942-2","url":null,"abstract":"<p><p>To investigative the white matter (WM) alterations in lung cancer patients with cancer pain (CP+), and explore the correlations between damaged WM fiber tracts and clinical indicators. Twenty-six CP+, 26 lung cancer patients without CP (CP-), and 31 healthy controls (HC) were recruited. All participants underwent diffusion tensor imaging (DTI) and clinical assessments. Automated fiber quantification (AFQ) technique was performed to identify the 20 WM fiber bundles, and the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were extracted. Intergroup comparisons of these diffusion metrics were conducted based on the entire fiber bundle level and 100 node levels along each tract. The associations between altered diffusion metrics and the numeric rating scale (NRS) scores, as well as the pain duration, were analyzed. At the entire level, the CP + group showed impaired WM structure in the right cingulum hippocampus (CH_R). At the pointwise level, the CP + group exhibited extensive nodal FA reduction or MD, RD, and AD elevation. In addition, the AD of the posterior portion of the right inferior longitudinal fasciculus (ILF_R, nodes 71-75) in the CP + group was positively correlated with the pain duration, and the FA of CH_R (nodes 22-38) was negatively correlated with NRS score. Extensive WM microstructural damage may be a pattern of brain abnormalities in lung cancer patients with CP, and in particular, specific nodal disruption along pain-related fiber tracts may be a sensitive imaging biomarker to characterize the severity and duration of CP.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of bacterial overgrowth in the small intestine with cortical thickness and functional connectivity in Parkinson's disease involving mild cognitive impairment.","authors":"Qian Zhou, Baiyuan Yang, Yongyun Zhu, Fang Wang, Yuchao Tai, Zhaochao Liu, Jieyu Chen, Chunyu Liang, Hongju Yang, Ailan Pang, Xinglong Yang","doi":"10.1007/s11682-024-00948-w","DOIUrl":"https://doi.org/10.1007/s11682-024-00948-w","url":null,"abstract":"<p><p>This study explored potential associations of bacterial overgrowth in the small intestine, as detected based on levels of hydrogen and methane in breath after lactulose consumption, with cortical thickness and resting-state functional connectivity in different brain regions. Prospective comparison of 35 patients with Parkinson's disease (PD) involving mild cognitive impairment, 35 patients with PD with normal cognitive function and 17 healthy controls showed the largest level of hydrogen alone and the largest combined level of hydrogen and methane in patients with mild cognitive impairment. The comparison also revealed a significant negative correlation between those levels and thickness of the right insular cortex. Mild cognitive patients showed different functional connectivity between the right insula and cognition-related brain networks from normal cognitive patients. Our results suggest that bacterial overgrowth in the small intestine may contribute to cortical thinning and alterations in resting-state functional connectivity in PD involving mild cognitive impairment. These insights support and deepen previous observations implicating the gut-brain axis in the neurological disorder.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential correlations of changes in in vivo neuroimaging markers of hippocampal volume and arteriolosclerosis with declining financial and health literacy in old age.","authors":"Lei Yu, Tianhao Wang, Alifiya Kapasi, Melissa Lamar, Gary Mottola, Konstantinos Arfanakis, David A Bennett, Patricia A Boyle","doi":"10.1007/s11682-024-00945-z","DOIUrl":"10.1007/s11682-024-00945-z","url":null,"abstract":"<p><p>Financial and health literacy is essential for older adults to navigate complex decision processes in late life. However, the neurobiological basis of age-related decline in financial and health literacy is poorly understood. This study aimed to characterize progression of neurodegenerative and vascular conditions over time, and to assess how these changes coincide with declining financial and health literacy in old age. Data came from 319 community-living older adults who were free of dementia at baseline, and underwent annual literacy assessments, as well as biennial 3-Tesla neuroimaging scans. Financial and health literacy was assessed using a battery of 32 items. Two in vivo neuroimaging markers of neurodegenerative and cerebrovascular conditions were used, i.e., hippocampal volume and the ARTS marker of arteriolosclerosis. A multivariate linear mixed effects model estimated the simultaneous changes in financial and health literacy, hippocampal volume, and the ARTS score. Over a mean of 7 years of follow-up, these older adults experienced a significant decline in financial and health literacy, a significant reduction in hippocampal volume, and a significant progression in ARTS score. Individuals with faster hippocampal atrophy had faster decline in literacy. Similarly, those with faster progression in ARTS also had faster decline in literacy. The correlation between the rates of hippocampal atrophy and declining literacy, however, was stronger than the correlation between the progression of ARTS with declining literacy. These findings suggest that neurodegeneration and, to a lesser extent, cerebrovascular conditions are correlated with declining financial and health literacy in old age.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between structural neuroimaging markers of Alzheimer's risk and scam susceptibility.","authors":"Melissa Lamar, Konstantinos Arfanakis, Alifiya Kapasi, S Duke Han, David A Bennett, Lei Yu, Patricia A Boyle","doi":"10.1007/s11682-024-00944-0","DOIUrl":"10.1007/s11682-024-00944-0","url":null,"abstract":"<p><p>Older adults with greater scam susceptibility are at greater risk for mild cognitive impairment and incident Alzheimer's dementia, regardless of baseline cognition. This, combined with documented associations between scam susceptibility and beta amyloid at death suggests that scam susceptibility may be an earlier indicator of pathological aging than cognition. Little, however, is known about whether in vivo neuroimaging markers of early-stage risk for Alzheimer's dementia are also related to scam susceptibility; such knowledge will inform upon the associations of neurodegenerative processes with scam susceptibility and may help identify vulnerable individuals. Participants were 472 community-based adults without dementia (age ~ 81y; 75% women) from the Rush Memory and Aging Project. Baseline 3T MRI T1-weighted structural and T2-weighted FLAIR data were used to assess the cortical thickness 'signature' of Alzheimer's disease (AD-CT) and white matter hyperintensity (WMH) burden, respectively. Scam susceptibility was measured using a questionnaire that assessed behaviors associated with vulnerability to fraud and scams. Demographically-adjusted linear effects regression models determined the relationship of each neuroimaging measure, first separately and then combined, with scam susceptibility. Reduced AD-CT was associated with higher levels of scam susceptibility (estimate=-0.10, standard error = 0.03, p = 0.002). WMH burden was not associated with scam susceptibility either alone or when combined in the same model as AD-CT (p-values ≥ 0.14). Results for AD-CT persisted after the inclusion of WMH burden. AD-CT was associated with scam susceptibility in older adults without dementia possibly signaling an in vivo profile of this behavior.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9/11 Veterans.","authors":"Aubrey A Knoff, Madeleine K Nowak, Emily J Van Etten, V Carlota Andreu-Arasa, Michael Esterman, Elizabeth C Leritz, Francesca C Fortenbaugh, William P Milberg, Catherine B Fortier, David H Salat","doi":"10.1007/s11682-024-00927-1","DOIUrl":"https://doi.org/10.1007/s11682-024-00927-1","url":null,"abstract":"<p><p>Metabolic syndrome is a collection of health factors that increases risk for cardiovascular disease. A condition of aging, metabolic syndrome is associated with reduced brain network integrity, including functional connectivity alterations among the default mode, regions vulnerable to neurodegeneration. Prevalence of metabolic syndrome is elevated in younger populations including post-9/11 Veterans and individuals with posttraumatic stress disorder, but it is unclear whether metabolic syndrome affects brain function in earlier adulthood. Identifying early effects of metabolic syndrome on brain network integrity is critical, as these impacts could contribute to increased risk for cognitive disorders later in life for Veterans. The current study examined whether metabolic syndrome and its individual components were associated with default mode functional connectivity. We also explored the contribution of posttraumatic stress disorder and traumatic brain injury on these metabolic syndrome-brain relationships. Post-9/11 Veterans with combat deployment history (95 with and 325 without metabolic syndrome) underwent functional magnetic resonance imaging to capture seed-based resting-state functional connectivity within the default mode. The metabolic syndrome group demonstrated reduced positive functional connectivity between the posterior cingulate cortex seed and the bilateral superior frontal gyrus. Data-driven analyses demonstrated that metabolic syndrome components, particularly cholesterol and central adiposity, were associated with widespread reductions in default mode network connectivity. Functional connectivity was also reduced in participants with metabolic syndrome but without current posttraumatic stress disorder diagnosis and with traumatic brain injury history. These results suggest that metabolic syndrome disrupts resting-state functional connectivity decades earlier than prior work has shown.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}