Brain Imaging and Behavior最新文献

{"title":"Cortical thickness alternation in obsessive-compulsive disorder patients compared with healthy controls.","authors":"Chunyu Dong, Hao Zheng, Hailong Shen, Yu Wan, Yinghong Xu, Ying Li, Liangliang Ping, Hao Yu, Chuanxin Liu, Jian Cui, Kun Li, Cong Zhou","doi":"10.1007/s11682-025-01010-z","DOIUrl":"https://doi.org/10.1007/s11682-025-01010-z","url":null,"abstract":"<p><p>Neuropathological changes, such as those found in obsessive-compulsive disorder (OCD), often include cortical morphological abnormalities. Neuroimaging research has indicated that individuals with OCD typically exhibit altered cortical thickness (CTh) through surface-based morphometry (SBM) analyses. Yet, the findings have been hit or miss, with inconsistent results across various studies. We are employing meta-analytic techniques on comprehensive brain imaging data to examine variations in CTh in patients with OCD. This approach could refine spatial precision in detection, thereby sharpening our diagnostic capabilities for OCD and paving the way for more targeted therapeutic interventions. The seed-based d mapping (SDM) method was utilized to perform a vertex-wise, coordinate-based meta-analysis (CBMA) examining CTh differences across whole-brain studies in OCD patients relative to healthy controls (HCs). This analytical approach systematically compared structural neuroimaging findings between clinical and control groups. A comprehensive review of existing research uncovered 9 relevant studies (containing 9 distinct datasets) examining CTh in OCD. The analysis incorporated data from 518 OCD patients and 449 HCs. The findings revealed significant cortical thinning in the left anterior cingulate and paracingulate gyri, along with the right insula among OCD patients. Conversely, increased CTh was observed in several left-hemisphere regions, including the lingual gyrus, orbital portion of the inferior frontal gyrus, and dorsolateral aspect of the superior frontal gyrus. Moreover, the meta-regression results indicated an inverse relationship between age and the thickness of the right insula cortex in those suffering from OCD. However, the analysis was constrained by the small pool of studies and samples, as well as incomplete data from certain participants, which hindered a thorough subgroup examination. Additionally, the results of the meta-regression should be viewed with caution, as they are based on a relatively limited number of studies. The analysis did show changes in CTh in certain brain areas for OCD patients, which adds to our knowledge of the intricate workings of OCD-related brain abnormalities. These insights could potentially serve as valuable landmarks for diagnosing and treating OCD. Clinical trial number: Not applicable.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired interhemispheric synchrony in Parkinson's disease patients with progressive cognitive impairment.","authors":"Xinhui Wang, Peng Liu, Qiurong Yu, Naying He, Yu Liu, Youmin Zhang, Fuhua Yan","doi":"10.1007/s11682-025-01009-6","DOIUrl":"https://doi.org/10.1007/s11682-025-01009-6","url":null,"abstract":"<p><p>Cognitive decline is a common non-motor symptom of Parkinson's disease (PD), which can occur at any stage of the disease. However, the neural mechanisms of PD cognitive changes remain unclear. It has been reported that hemispheric asymmetry is associated with cognitive impairment. Thus, we aimed to explore the underlying mechanisms of PD subgroups with different degrees of cognitive progression by assessing functional interhemispheric coordination and their relations with cognition. Fifty-four PD patients including 29 stable cognitive performance (sPD) patients, 25 progressive cognitive impairment (pPD) patients, and 18 healthy controls (HC) were recruited in this study. All subjects underwent T1-weighted, resting-state functional magnetic resonance imaging scanning, and neuropsychological evaluations. Voxel-mirrored Homotopic Connectivity (VMHC) and voxel-based morphometry analysis were applied to detect functional interhemispheric coordination. Fisher z transformed VMHC (z-VMHC) value lower in the middle temporal gyrus (MTG), middle occipital gyrus (MOG), and superior temporal gyrus (STG) in the pPD group when compared to the sPD group. However, we did not detect the difference in gray matter volume among the three groups. Furthermore, the z-VMHC value of MTG and MOG was positively correlated with the Montreal Cognitive Assessment (MoCA) score of the follow-up. Therefore, z-VMHC values within the MTG, MOG, and STG appeared to be potential neuroimaging features to distinguish pPD patients from sPD groups. These findings may underlie the neural mechanisms of cognitive performance in PD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered resting-state functional connectivity in male individuals with methamphetamine use disorder at two different withdrawal periods: spotlight on the paraventricular thalamic nucleus.","authors":"Yifan Li, Shubao Chen, Shucai Huang, Zhe Du, Qiuping Huang, Shuhong Lin, Xinwen Wen, Chenhan Wang, Tieqiao Liu, Hongxian Shen, Xuyi Wang, Kai Yuan","doi":"10.1007/s11682-025-01008-7","DOIUrl":"https://doi.org/10.1007/s11682-025-01008-7","url":null,"abstract":"<p><p>Preclinical research highlights the paraventricular thalamic nucleus as important in various stages of substance use disorder. However, there is limited research on it in relation to methamphetamine, especially regarding its functional changes after long-term abstinence. This study aims to understand the alterations in functional connectivity of the paraventricular thalamic nucleus in methamphetamine abstainers and its correlation with drug craving at two different withdrawal periods. A total of 49 subjects were allocated to the short-term withdrawal group, 44 to the long-term withdrawal group, and 42 to the healthy control group, all of whom are male and adult. Craving scores were assessed using a visual analogue scale. Functional connectivity was evaluated through resting-state functional MRI, which reflects the correlation between connectivity in different brain regions. Significant differences in functional connectivity between the paraventricular thalamic nucleus and the left caudate nucleus were observed across the three groups. The healthy control group exhibited the strongest connectivity, followed by the long-term withdrawal group, while the short-term withdrawal group demonstrated the weakest connectivity. Within the short-term withdrawal group, functional connectivity of the paraventricular thalamic nucleus with both the left parahippocampal gyrus (r = -0.45, p = 0.001) and the left inferior temporal gyrus (r = -0.43, p = 0.002) was significantly correlated with craving scores. This study confirms abnormalities in the paraventricular thalamic nucleus among male methamphetamine abstainers, emphasizes its potential role in regulating methamphetamine use disorder and craving mechanisms, and offers insights into long-term changes in brain function after abstinence.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life adversity and white matter microstructural organization-a systematic review.","authors":"Orla Mitchell, Darren W Roddy, Michael Connaughton","doi":"10.1007/s11682-025-01007-8","DOIUrl":"https://doi.org/10.1007/s11682-025-01007-8","url":null,"abstract":"<p><p>Early life adversity, defined as exposure to stressful events during childhood, is a significant risk factor for the development of psychiatric disorders. Diffusion tensor imaging studies employing tract-based spatial statistics have shown microstructural abnormalities in white matter among individuals exposed to early life adversity; however, robust conclusions are yet to be drawn. This systematic review synthesizes findings of previous tract-based spatial statistics studies to identify the white matter alterations in adult brains exposed to early life adversity, in papers with methodological consistency. The literature search (April 2024) was conducted to identify tract-based spatial statistics studies that compared diffusion metrics between adults exposed to early life adversity and adults not. Embase, Pubmed, and PsycInfo were searched, retrieving 2458 articles. Following deduplication, 1739 titles and/or abstracts were screened. 1699 articles were excluded, and 40 full texts were reviewed. Seven articles, reporting on 764 subjects, met the inclusion criteria and were included in the narrative synthesis. Compared to controls, adults exposed to early life adversity showed lower fractional anisotropy values in white matter tracts of the limbic and visual processing systems, specifically the anterior thalamic radiation, inferior longitudinal fasciculus, corona radiata, uncinate fasciculus, inferior fronto-occipital fasciculus, and cingulum bundle. This systematic review highlights that early life adversity may underlie emotional dysregulation and contribute to an increased risk of psychopathology in later life and explores the potential neurobiological mechanisms that underpin these structural changes. Understanding these associations is crucial for developing targeted interventions aimed at mitigating the long-term impact of early life adversity.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.","authors":"Stacy N Hudgins, Adrian Curtin, Joseph Tracy, Hasan Ayaz","doi":"10.1007/s11682-025-01006-9","DOIUrl":"https://doi.org/10.1007/s11682-025-01006-9","url":null,"abstract":"<p><p>Cognitive dysmetria suggests a disorganization of cognitive processes, particularly in relation to the cerebellum's role in coordinating thoughts and actions. This phenomenon has been extensively studied in various psychiatric disorders, including schizophrenia (SCHZ), bipolar disorder II (BIPOL), and attention-deficit/hyperactivity disorder (ADHD). Understanding the relationship between cognitive dysmetria and functional connectivity in these disorders would reveal significant insights into their neurobiological underpinnings. This study explores how distinct and similar functional network connectivity (FNC) patterns between brain regions are associated with clinical symptoms and trait assessments across SCHZ, BIPOL, and ADHD patients by examining both working memory and task-free conditions compared to healthy volunteers (HC). Leveraging an open-source fMRI dataset from the UCLA Consortium for Neuropsychiatric Phenomics, we analyzed FNC patterns across 115 default mode and salience network regions, including cortical, subcortical, and cerebellar regions of interest in 135 participants (39 HC, 27 SCHZ patients, 38 BIPOL patients, and 31 ADHD patients). Abnormal FNC patterns compared to HC were localized to the cerebellar, thalamic, striatal, hippocampal, medial prefrontal and anterior insular cortices. Post-hoc multiple comparison analysis showed abnormal network connectivity predominantly in SCHZ and ADHD patients during rest, while the task condition demonstrated differential effects across all three disorders. Statistical analysis using a factor-by-covariance approach (GLM MANCOVA) suggested that regional functional connectivity was associated with select symptoms and traits pointing to neural signatures underlying psychiatric conditions. Our study suggests that examining and harnessing dysfunctional relationships in subcortical and cerebellar regions could provide a new perspective on the neurobiological basis of psychoses and help improve available treatment strategies.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biographical information influences on facial attractiveness judgment.","authors":"Sajina Rodríguez, Estefanía Hernández-Martín, Julio Plata-Bello","doi":"10.1007/s11682-025-01005-w","DOIUrl":"https://doi.org/10.1007/s11682-025-01005-w","url":null,"abstract":"<p><p>In the realm of social cognition, facial perception is crucial, particularly in assessing facial attractiveness. This study investigated how biographical information impacts such evaluations. Two experiments were conducted: the first had participants rate 108 faces with and without biographical details, including occupation, psychiatric history, and politics. The second used fMRI to identify brain regions reacting differently with biographical information. Results showed that 31.48% of cases exhibited significant variations in facial evaluations when biographical information was introduced. The fMRI experiment highlighted heightened activity in the left Inferior Frontal Gyrus (IFG) and the left Middle Temporal Gyrus (MTG) when assessing facial attractiveness with biographical information, especially related to occupation or psychiatric history as opposed to politics. In summary, incorporating biographical information can substantially alter perceptions of facial attractiveness, engaging specific brain regions like the left IFG and left MTG. The results of this study could have significant implications for the understanding of social cognition and, among other aspects, for the destigmatization of personal histories in the field of mental health.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the relationship between brain activation and clinical indicators in amnestic mild cognitive impairment.","authors":"Hye-Min Heo, Kyeong-Hwa Lee, Kyeong-Hwa Heo, Ye-Chae Hwang, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Chang-Nam Ko, Hyug-Gi Kim, Geon-Ho Jahng, Jung-Mi Park","doi":"10.1007/s11682-025-01004-x","DOIUrl":"https://doi.org/10.1007/s11682-025-01004-x","url":null,"abstract":"<p><p>This study aimed to identify the clinical symptoms and indicators that might affect brain activity in patients with amnestic mild cognitive impairment. Thirty-one patients with amnestic mild cognitive impairment were recruited between March 2022 and June 2023. Functional magnetic resonance imaging, neuropsychological tests, and blood tests were also performed. Brain activation was analyzed using voxel- and region-of-interest-based methods. The correlation between the functional magnetic resonance imaging results and the acquired clinical indicators was determined using Pearson's correlation analysis. In the face-name association memory task, activation of the hippocampus and parahippocampal gyrus was found to be negatively correlated with the Short Form of the Geriatric Depression Scale score. Precentral gyrus and precuneus activation positively correlated with the percentage of correct answers in the one-back task. In the working memory N-back task, activation of the superior parietal lobule was positively correlated with the percentage of correct answers in the zero-back task. Age and activation in the hippocampus and parahippocampal gyrus are positively correlated. Depression, age, and sex significantly affected brain activity. Activation of the precentral gyrus, superior parietal lobule, and precuneus influences N-back task competency. Overall, this study is the first to analyze the correlation between brain function and clinical indicators of amnestic mild cognitive impairment.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of affective forecasting in individuals with high trait anxiety: evidence from resting-state functional connectivity.","authors":"An Xie, Peng Liu, Qin Zhou, Tao Chen, Dao-Qun Ding, Rui-Ting Zhang","doi":"10.1007/s11682-025-01002-z","DOIUrl":"https://doi.org/10.1007/s11682-025-01002-z","url":null,"abstract":"<p><p>Previous literature has indicated that individuals with high trait anxiety have negative bias in forecasting future emotions, but the neural mechanisms underlying this remain unclear. Individuals with high trait anxiety (HTA; n = 38) and individuals with low trait anxiety (LTA; n = 38) were recruited. All participants completed the Social Affective Forecasting task and underwent resting-state fMRI scanning. Compared with the LTA group, the HTA group anticipated lower levels of arousal for future positive events but showed comparable performance for anticipated valence for future positive events. Moreover, the HTA group demonstrated intact performance in reporting anticipated valence and anticipated arousal for future negative events. In addition, the HTA group demonstrated increased functional connectivity between the left ventromedial prefrontal cortex (vmPFC) and left lingual gyrus relative to the LTA group. Besides, the HTA group also showed increased functional connectivity between the dorsal anterior insula and right posterior cingulate cortex compared to the LTA group. No significant associations were found between the altered functional connectivity and affective forecasting performance. Increased functional connectivity observed in the HTA group suggested that HTA individuals may devote more efforts when anticipating future events, to maintain intact in anticipating valence for future events.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered functional connectivity within and between resting-state networks in ulcerative colitis.","authors":"Yanjun Ren, Kaizhong Xue, Huijuan Xu, Lijie Hao, Quchuan Zhao, Tianyu Chi, Hongwei Yang, Xiaojing Zhao, Defeng Tian, Huihong Zhai, Jie Lu","doi":"10.1007/s11682-025-01001-0","DOIUrl":"https://doi.org/10.1007/s11682-025-01001-0","url":null,"abstract":"<p><p>Patients with ulcerative colitis (UC) often exhibit affective disorders, such as depression and anxiety. The underlying neurological mechanisms of these symptoms, however, remain poorly understood. This study aimed to explore alterations in functional connectivity (FC) both within and between resting-state networks (RSNs) in individuals with ulcerative colitis. Twelve meaningful RSNs were identified from 22 ulcerative colitis patients and 23 healthy controls using independent component analysis of functional magnetic resonance imaging data. Correlation analyses were performed between clinical indices, neuropsychological assessments and neuroimaging data. Compared with healthy controls, UC patients showed increased intranetwork FC, mainly located in the right temporal pole, orbitofrontal cortex, and left superior temporal and Rolandic opercular cortices within the auditory network. Increased intranetwork FC in the Rolandic opercular cortex was also observed in UC patients during remission phase, while no significant alterations were detected in patients with active-phase UC. In addition, UC patients exhibited increased connectivity between the dorsal attention and the left frontoparietal network, as well as between the anterior default mode network and the posterior default mode network, with distinct patterns of internetwork connectivity observed across different clinical phases. No significant correlations were found between altered brain regions and psychological scales in UC patients. These findings imply that UC patients may undergo functional network alterations, affecting both intranetwork connectivity within RSNs and internetwork connectivity between RSNs.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients.","authors":"Lijun Kang, Qian Gong, Wei Wang, Zhaowen Nie, Lihua Yao, Dan Xiang, Ning Tu, Hongyan Feng, Huiling Wang, Gaohua Wang, Lihong Bu, Zhongchun Liu","doi":"10.1007/s11682-025-00983-1","DOIUrl":"https://doi.org/10.1007/s11682-025-00983-1","url":null,"abstract":"<p><p>Major depressive disorder (MDD) exhibits a moderate degree of heritability and shares common influences with early adverse life events, as well as being associated with inconsistent changes in cerebral blood flow (CBF). Here, we investigated whether MDD polygenic risk score (PRS) and emotional neglect influences alterations in CBF. We collected blood and ASL from MDD patients. Emotional neglect (EN) assessment was performed using the Childhood Trauma Questionnaire. We calculated PRS for MDD based the MDD GWAS result in Asian populations. Subsequently, we examined the interaction between PRS for MDD and EN on CBF. Finally, 174 participated in statistical analysis. After adjusting for confounding factors, there was a significant main effect of PRS on left dorsolateral superior frontal gyrus, while the main effect of EN was not significantly (P < 0.001, GRF corrected). And significant interactive effect was found between PRS of MDD and EN on precuneus CBF (P < 0.001, GRF corrected). In MDD, high polygenic risk independently influenced changes in left dorsolateral superior frontal gyrus CBF, while EN plays a role in individuals with a higher genetic risk for MDD. Our study indicates the need to consider the combined effects of genetic risk and early adverse events on alterations in brain structure in the occurrence of MDD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}