Yuchao Tai, Wei Huang, Yongyun Zhu, Bin Liu, Fang Wang, Zhaochao Liu, Chunyu Liang, Jin Tian, Hongju Yang, Huiren, Xinglong Yang
{"title":"Analysis of parkinson's disease patients with Gastrointestinal symptoms using structural and functional magnetic resonance imaging.","authors":"Yuchao Tai, Wei Huang, Yongyun Zhu, Bin Liu, Fang Wang, Zhaochao Liu, Chunyu Liang, Jin Tian, Hongju Yang, Huiren, Xinglong Yang","doi":"10.1007/s11682-025-01057-y","DOIUrl":"https://doi.org/10.1007/s11682-025-01057-y","url":null,"abstract":"<p><p>Gastrointestinal symptoms are one of the most common non-motor symptoms in Parkinson's disease. This study aimed to investigate the neuroimaging mechanisms underlying gastrointestinal symptoms associated with Parkinson's disease using functional connectivity and voxel-based morphometry. The study included 50 healthy controls, 71 Parkinson's disease patients without gastrointestinal symptoms and 84 patients with gastrointestinal symptoms. Differences in gray matter volume among the three groups were assessed. Given a significant decrease in gray matter volume in the right cerebellar hemisphere, it was selected as the seed region for functional connectivity analysis.The Parkinson's disease patients with gastrointestinal symptoms showed significant differences in disease duration, levodopa equivalents daily dose, Hoehn and Yahr stage, unified Parkinson's disease rating scale part Ⅲ, Hamilton anxiety scale, Scales for Outcomes in Parkinson's disease-Autonomic, non-motor symptom scale, Montreal cognitive assessment, and orthostatic hypotension compared to the patients without gastrointestinal symptoms (p<0.05). Lower gray matter volume was observed in the group with gastrointestinal symptoms, particularly in the bilateral cerebellum hemisphere and the left superior temporal gyrus. Compared to the group without gastrointestinal symptoms, functional connectivity between the right cerebellar hemisphere and the right medial and lateral cingulate gyrus and left middle temporal lobe was significantly increased.Parkinson's disease patients with gastrointestinal symptoms present with a prolonged disease course and increased severity of both motor and non-motor symptoms. The gastrointestinal symptoms in Parkinson's disease patients may be associated with structural and functional brain alterations.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence for cognitive compensation mechanism in the postoperative delirium: a prospective multi-modal neuroimaging cohort study.","authors":"Guo-Bin Zhang, Hao-Yi Li, Jia-Mei Lv, Xiao-Kang Zhang, Yong-Gang Wang, Yun-Yun Duan, Hong-Yan Chen, Zhi-Zheng Zhuo, Ya-Ou Liu, Hua-Wei Huang","doi":"10.1007/s11682-025-01048-z","DOIUrl":"https://doi.org/10.1007/s11682-025-01048-z","url":null,"abstract":"<p><p>To explore the effect of brain cognitive compensation on the pathogenesis of postoperative delirium (POD) in the frontal glioma patients. Eighty-four adult patients with unilateral frontal glioma who underwent elective craniotomy and 37 healthy controls were recruited. Primary outcomes were POD during postoperative 1-7 days, as assessed by Confusion Assessment Method. Cognition before surgery was measured by the battery of neuropsychological tests. Then we evaluated gray matter volume (GMV) and white matter integrity (i.e. fractional anisotropy (Casey et al.)) by presurgical voxel-based morphometry and diffusion tensor imaging. We investigated the association between presurgical structural index of potential compensatory brain regions with POD incidence and severity. POD occurred in 13 of 67 subjects (19.4%). Pearson correlation revealed a tendency of negative correlation between the GMV in the contralateral dorsal lateral prefrontal cortex (DLPFC) and glioma grade. After controlling for age, gender and education, partial correlation analysis suggested that the GMV in the contralateral DLPFC was significantly positive correlated with presurgical cognition, and negatively correlated with POD incidence and severity (all P < 0.05); and the FA value of the genu of the corpus callosum was significantly positively correlated with the GMV in the contralateral DLPFC and preoperative cognition, while was negative correlated with the incidence and severity of POD (all P < 0.05). Our findings showed that compensation of contralateral DLPFC could decrease the risk and severity of POD in patients with frontal glioma. Our findings provide imaging-based evidence for the presence of cognitive compensation in the development of POD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guojun Xu, Bin Lin, Yun Jiang, Jie Ming, Linhui Ni, Guocan Han, Zhiyong Zhao, Huaying Cai, Lulu Gao
{"title":"Hippocampal subfield-specific alterations in post-stroke dementia with subcortical lesion.","authors":"Guojun Xu, Bin Lin, Yun Jiang, Jie Ming, Linhui Ni, Guocan Han, Zhiyong Zhao, Huaying Cai, Lulu Gao","doi":"10.1007/s11682-025-01034-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01034-5","url":null,"abstract":"<p><p>The structural and functional characteristics of hippocampal subfields have been extensively studied in dementia, with findings indicating stronger associations with cognitive performance than those observed in the whole hippocampus (HP). However, the impact of post-stroke dementia (PSD) on the structural and functional connectivity between hippocampal subfields and cortical regions remains unclear. The objective of this study is to examine alterations in the functional and structural connectivity between hippocampal subfields and cortical regions in PSD. We collected resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data from 24 PSD patients, 36 post-stroke non-demented (PSND) patients, and 21 normal controls (NC). These data were used to estimate fractional amplitude of low-frequency fluctuations (fALFF), fractional anisotropy (FA), and diffusivity maps in the hippocampal subfields. Additionally, we constructed functional and structural connectivity matrices between hippocampal subfields and cortical regions for each participant, highlighting group-specific connectivity alterations. Statistical analyses were conducted using a linear mixed model to compare group differences and assess the relationship between MRI measures and clinical evaluations. Our results revealed distinct PSD-related changes in functional connectivity, particularly with the temporal-occipital cortex, within hippocampal subfields compared to the whole HP. Notably, different subfields contributed differently to connectivity changes within the entire HP. Furthermore, we identified positive correlations between diffusivity in the bilateral hippocampal tails and illness duration in PSND patients, which were not observed in PSD. These findings highlight the significant impact of PSD on hippocampal subfields, with subfield analysis offering new insights into the underlying mechanisms of PSD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mingyu Li, Yachen Shi, Lin Ma, Haixia Mao, Min Xu, Qianqian Gao, Jiayi Yang, Feng Wang, Xiangming Fang, Xiaoyun Hu
{"title":"Cognitive reserve mitigates cognitive impairment in cerebral small vessel disease by protecting white matter fibers: an automated fiber quantification study.","authors":"Mingyu Li, Yachen Shi, Lin Ma, Haixia Mao, Min Xu, Qianqian Gao, Jiayi Yang, Feng Wang, Xiangming Fang, Xiaoyun Hu","doi":"10.1007/s11682-025-01032-7","DOIUrl":"https://doi.org/10.1007/s11682-025-01032-7","url":null,"abstract":"<p><p>This study investigates how cognitive reserve (CR), developed through education and other cognitive activities, can slow cognitive dysfunction in cerebral small vessel disease (CSVD) patients by examining cerebral white matter fiber connectivity. We prospectively enrolled 125 patients with CSVD from the Department of Neurology between 2021 and 2023, including 69 patients with no cognitive impairment (nonCI) and 56 patients with mild cognitive impairment (MCI). Patients were divided into low cognitive reserve (LCR) and high cognitive reserve (HCR) subgroups based on the median of years of education (≤ 9 vs. >9 years). All participants underwent 3.0T MRI scans and neuropsychological assessments. Fractional anisotropy (FA) and mean diffusivity (MD) values of fiber bundles detected by automated fiber quantification (AFQ) were compared among groups by two-way analysis of variance, considering disease state and CR as factors. Correlation analyses examined the relationships between significant fiber segments and cognitive function. We found that the MCI group exhibited decreased FA and increased MD in specific segments of some fiber tracts, such as the corpus callosum splenium, bilateral thalamic radial tracts, and bilateral inferior frontal occipital tracts compared to the nonCI group. The LCR group had decreased FA in the left corticospinal tract and increased MD in the right corticospinal tract compared to the HCR group. Significant interactions of FA values were observed in the left arcuate fasciculus(F = 3.949, P < 0.05), particularly in segments related to information processing speed and memory. The MCI group exhibited poorer white matter fiber integrity than the nonCI group. These findings suggest that the left arcuate fasciculus may partially mediate CR's protective effects on cognitive dysfunction in patients with CSVD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cerebral network topology and peak width of skeletonized mean diffusivity changes associated with cognitive impairment in patients with obstructive sleep apnea.","authors":"Xiaoshan Lin, Shiwei Lin, Fajian Wei, Shengli Chen, Qunjun Liang, Shuo Li, Yingwei Qiu","doi":"10.1007/s11682-025-01045-2","DOIUrl":"https://doi.org/10.1007/s11682-025-01045-2","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize the network topology and peak width of skeletonized mean diffusivity (PSMD) and their correlation with cognitive impairment in obstructive sleep apnea (OSA) patients and to assess whether such impairments are reversible after treatment.</p><p><strong>Methods: </strong>Ninety-one OSA patients and 30 healthy controls (HCs) participated. Patients were classified into mild group (n = 37) and moderate-severe group (n = 54) based on apnea-hypopnea index. Cognitive performances, including execution, visual memory, attention, and psychomotor speed were assessed. Network topological properties and PSMD, derived from resting-state functional MRI and diffusion imaging, were compared and correlated with their cognitive performance. Alterations in network topology, PSMD, and cognitive performance after treatment were assessed in a subcohort of patients.</p><p><strong>Results: </strong>OSA patients had worse performance in the digit symbol test and Stroop color-word test than HCs, whereas the performance of moderate-severe OSA patients decreased more significantly. Mild OSA patients had compromised degree centrality of cognitive control, while moderate-severe OSA patients had compromised topological properties involving cognitive control, default mode, limbic, and auditory network relative to HCs, and had higher PSMD than mild OSA patients and HCs. Aberrant PSMD and functional nodal network metrics closely correlated with cognitive decline in OSA patients. Notably, functional network topology and cognitive performance partially improved in patients after treatment.</p><p><strong>Conclusions: </strong>Progressive compromise of the PSMD and functional network topology may underlie the cognitive deficits in attention and processing speed in OSA patients. The disruption of functional network topology and cognitive performance are partially reversible in OSA patients after treatment.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional connectivity of the periaqueductal grey subdivisions is disrupted in chronic low back pain.","authors":"Cuiping Mao, Bo Zhang, Minmin Guo, Ting Dong, Huajuan Yang, Quanxin Yang, Liang Zhang, Qiujuan Zhang","doi":"10.1007/s11682-025-01047-0","DOIUrl":"https://doi.org/10.1007/s11682-025-01047-0","url":null,"abstract":"<p><p>Chronic low back pain (cLBP) is a common musculoskeletal condition worldwide. Previous studies have implicated the periaqueductal grey (PAG) in pain modulation of cLBP. However, the PAG has subdivisions with distinct functions. Characterizing the function of PAG subdivisions will help to elucidate the specific role of PAG in cLBP. Here, we explored the functional connectivity alterations of the PAG subdivisions in 75 cLBP patients as compared with 75 healthy controls, and correlated the neuroimaging findings with clinical measures. Results suggested significantly enhanced resting-state functional connectivity (rsFC) in the bilateral ventrolateral PAG (bivlPAG)-bilateral postcentral gyrus (PoCG)/left superior parietal lobe (SPL, p = 0.037, false discovery rate [FDR] corrected) and decreased rsFC in the bilateral lateral PAG-bilateral precuneus/posterior cingulate cortex (PCC, p < 0.001, FDR corrected) pathways in cLBP subjects compared with healthy controls. When performing attention-demanding task, cLBP subjects showed significantly decreased connectivity between the bivlPAG and dorsal medial prefrontal cortex (dmPFC) (p < 0.001, FDR corrected)/right cerebellum (p = 0.004, FDR corrected), as well as increased connectivity between the bivlPAG and left precentral gyrus (PreCG)/PoCG (p = 0.002, FDR corrected), compared with healthy controls. Negative correlations were suggested between bivlPAG-PoCG/SPL rsFC and depression scores (r = -0.322, p = 0.025, FDR corrected) and between the task-related functional connectivity of the vlPAG-PoCG and disease duration (r = -0.278, p = 0.04, FDR corrected) in the cLBP group. These findings suggest disrupted descending pain modulation via the PAG-S1 pathway and impaired attention modulation via the vlPAG-dmPFC and vlPAG-PreCG/PoCG pathways in cLBP patients.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoping Yi, Xueying Wang, Liying Shen, Yan Fu, Qian Xiao, Jinfan Zhang, Jun Ding, Furong Jiang, Zhejia Zhang, Alessandro Grecucci, Bihong T Chen
{"title":"White matter microstructural abnormalities related to emotional dysfunction and childhood trauma characterize adolescents with borderline personality disorder.","authors":"Xiaoping Yi, Xueying Wang, Liying Shen, Yan Fu, Qian Xiao, Jinfan Zhang, Jun Ding, Furong Jiang, Zhejia Zhang, Alessandro Grecucci, Bihong T Chen","doi":"10.1007/s11682-025-01046-1","DOIUrl":"https://doi.org/10.1007/s11682-025-01046-1","url":null,"abstract":"<p><strong>Background: </strong>The neurobiological mechanism underlying adolescent borderline personality disorder (BPD) remains unclear. This study aimed to assess white matter (WM) microstructural abnormalities associated with emotional dysfunction and childhood trauma in adolescents with BPD.</p><p><strong>Methods: </strong>This study enrolled 53 adolescents aged 12-17 years with BPD and 39 healthy controls (HC). Radial diffusivity (RD) and axial diffusivity (AD) were generated using Tract-Based Spatial Statistics (TBSS) analysis of the diffusion tensor imaging (DTI) data. Correlation analysis was conducted to assess the relationship of the DTI parameters with non-suicidal self-injurious behavior (NSSI) and childhood trauma in adolescents with BPD.</p><p><strong>Results: </strong>Adolescents with BPD had lower AD values in the splenium of the corpus callosum, left anterior corona radiata and left external capsule, but higher RD values in the genu of the corpus callosum, body of the corpus callosum, right anterior corona radiata, and right uncinate fasciculus as compared to the HC group (p < 0.05, 5000 permutations). Increased RD values in the body of corpus callosum and right uncinate fasciculus were positively correlated with the NSSI score (p < 0.05). Increased RD value in the right anterior corona radiata was positively correlated with childhood trauma (p < 0.05).</p><p><strong>Conclusions: </strong>This study identified alterations within the cortical-limbic system in adolescents with BPD, which was correlated with NSSI and childhood trauma. WM diffusivity parameters may serve as potential neuroimaging biomarkers in adolescents with BPD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The association of glymphatic system function with cognitive decline in PD-FOG: multimodal MRI evidence from cross-sectional and longitudinal studies.","authors":"Xiuhang Ruan, Mengfan Wang, Xiaofei Huang, Ting Wang, Mengyan Li, Xinhua Wei","doi":"10.1007/s11682-025-01044-3","DOIUrl":"https://doi.org/10.1007/s11682-025-01044-3","url":null,"abstract":"<p><p>This study aims to investigate glymphatic system dysfunction in idiopathic Parkinson's disease (PD) using a dual-cohort design, focusing on its associations with freezing of gait (FOG) and cognitive decline. A cross-sectional analysis was conducted on 43 PD patients with FOG, 106 without FOG, and 46 healthy controls. A longitudinal study followed 146 early-stage PD patients from the Parkinson's Progression Markers Initiative database over five years, with 65 developing FOG. Covariate analysis was performed, controlling for variables like gender, age, and education. Survival analysis compared cognitive decline between FOG and stable groups. Random forest analysis identified key predictors of FOG development. The cross-sectional study demonstrated significantly enlarged normalized choroid plexus volume in PD patients with FOG compared to healthy controls. Both FOG and non-FOG groups showed increased perivascular space enlargement in the basal ganglia and centrum semiovale, as well as reduced average analysis along the perivascular space index compared to healthy controls. PD patients with FOG exhibited more pronounced disease progression and cognitive decline than those without FOG. Glymphatic markers were associated with age, cognitive scores, and gait performance. The longitudinal study showed slightly more severe motor symptoms and accelerated cognitive decline in the FOG group during follow-up. Random forest analysis identified age, cognitive scales, and glymphatic function metrics as robust predictors of FOG development. These findings highlight the potential significance of brain glymphatic system function in the development of freezing of gait and cognitive decline in PD patients, offering novel neuroimaging biomarkers for early detection. These authors have contributed equally to this work and share first authorship.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huijie Yuan, Zhaoyao Luo, Jing Yang, Shaohui Ma, Peng Li, Xinyi Wang, Hang Su, Ronghua He, Junya Mu, Yuchen Zhang
{"title":"Mild cognitive impairment is associated with effect of uremic metabolites on gray matter structural changes in end-stage kidney disease.","authors":"Huijie Yuan, Zhaoyao Luo, Jing Yang, Shaohui Ma, Peng Li, Xinyi Wang, Hang Su, Ronghua He, Junya Mu, Yuchen Zhang","doi":"10.1007/s11682-025-01003-y","DOIUrl":"10.1007/s11682-025-01003-y","url":null,"abstract":"<p><p>To investigate the grey matter volume (GMV) changes and uremic metabolites in end-stage kidney disease (ESKD) patients with mild cognitive impairment (MCI) (ESKD-MCI) and further examine the classification and diagnostic efficacy of these features for ESKD-MCI patients. A total of 65 patients with ESKD, including 34 ESKD-MCI and 31 with non-cognitive impairment (ESKD-NCI), and 55 health controls (HCs) were enrolled. All participants underwent brain structural magnetic resonance imaging (MRI) scanning and Montreal cognitive assessment test. Clinical characteristics and GMV differences among these three groups were analyzed. In addition, mediation analysis was performed to determine the mediating effect of GMV changes on the association between clinical risk factors and MCI. Finally, support vector machine were employed to examine the classification and diagnostic efficacy of GMV changes and clinical features for MCI. Both patient groups exhibited widespread structural brain injury compared with the HCs. Moreover, compared with ESKD-NCI, ESKD-MCI patients demonstrated reduced GMV specifically in the left middle temporal gyrus and inferior temporal gyrus. Notably, these GMV changes completely mediates the effect of serum phosphorus levels on MCI. Furthermore, imaging features rather than serum phosphorus levels had good classification and diagnostic efficacy for ESKD-MCI. Our findings underscore the significance of the left temporal gyrus as a pivotal brain region in ESKD-MCI patients, fully mediating the link between uremic metabolite and MCI. GMV alterations presents a promising avenue for effectively detecting MCI in individuals with ESKD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"835-845"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impaired interhemispheric synchrony in Parkinson's disease patients with progressive cognitive impairment.","authors":"Xinhui Wang, Peng Liu, Qiurong Yu, Naying He, Yu Liu, Youmin Zhang, Fuhua Yan","doi":"10.1007/s11682-025-01009-6","DOIUrl":"10.1007/s11682-025-01009-6","url":null,"abstract":"<p><p>Cognitive decline is a common non-motor symptom of Parkinson's disease (PD), which can occur at any stage of the disease. However, the neural mechanisms of PD cognitive changes remain unclear. It has been reported that hemispheric asymmetry is associated with cognitive impairment. Thus, we aimed to explore the underlying mechanisms of PD subgroups with different degrees of cognitive progression by assessing functional interhemispheric coordination and their relations with cognition. Fifty-four PD patients including 29 stable cognitive performance (sPD) patients, 25 progressive cognitive impairment (pPD) patients, and 18 healthy controls (HC) were recruited in this study. All subjects underwent T1-weighted, resting-state functional magnetic resonance imaging scanning, and neuropsychological evaluations. Voxel-mirrored Homotopic Connectivity (VMHC) and voxel-based morphometry analysis were applied to detect functional interhemispheric coordination. Fisher z transformed VMHC (z-VMHC) value lower in the middle temporal gyrus (MTG), middle occipital gyrus (MOG), and superior temporal gyrus (STG) in the pPD group when compared to the sPD group. However, we did not detect the difference in gray matter volume among the three groups. Furthermore, the z-VMHC value of MTG and MOG was positively correlated with the Montreal Cognitive Assessment (MoCA) score of the follow-up. Therefore, z-VMHC values within the MTG, MOG, and STG appeared to be potential neuroimaging features to distinguish pPD patients from sPD groups. These findings may underlie the neural mechanisms of cognitive performance in PD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"811-820"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}