Brain Imaging and Behavior最新文献

{"title":"Cortical volumetry and longitudinal cognitive changes in Parkinson's disease: insights from the COPPADIS cohort.","authors":"Tania Álvarez-Avellón, Carmen Solares, Juan Álvarez-Carriles, Pablo Franco-Rosado, Patricia Diaz-Galvan, Diego Santos-García, Pablo Mir, Manuel Menéndez-González","doi":"10.1007/s11682-025-01031-8","DOIUrl":"https://doi.org/10.1007/s11682-025-01031-8","url":null,"abstract":"<p><p>Cognitive decline is a major non-motor symptom in Parkinson's disease (PD), often linked to brain atrophy. This study examines the relationship between cortical atrophy and age groups in predicting cognitive decline in PD over five years. 188 PD patients from the COPPADIS cohort were stratified by age: young (30-55 years, N = 47), middle-aged (56-65 years, N = 59), and older adults (66-75 years, N = 82). Baseline cortical volume was assessed using T1-weighted MRI, and cognitive decline was evaluated using the annual rate of change of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS). Parametric or non-parametric tests were applied to evaluate group differences. Main analyses consist of several multiple regression analyses to examine associations between baseline brain atrophy and cognitive decline by age group. Older adults exhibited significantly greater cognitive decline in comparison to the younger age groups in the three compose scores of the PDCRS -Fronto-subcortical (H(2) = 41.08, p < 0.001), Posterior Cortical (H(2) = 22.03, p < 0.001), and Total(H(2) = 41.13, p < 0.001). Higher educational level has a significant positive effect on older adults, specifically for working memory performance, delayed verbal memory and the fronto-subcortical composed score. Multiple regression models underscored the predictive value of the bilateral hippocampus, bilateral medial orbitofrontal cortex, right precuneus, and right isthmus cingulate gyrus, together with being an older adult or having a higher education. MRI measures, age, and education predict cognitive decline in PD. Longitudinal assessments are essential for refining atrophy-cognition correlations and optimizing patient stratification.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structural reorganization mediates the relationship between hearing loss and cognitive impairment.","authors":"Yao Wang, Jianfen Luo, Wenqing Li, Yu Han, Wen Ma, Siqi Liu, Lei Xu, Zhaomin Fan, Yu Ai, Meixia Su, Fuxin Ren, Fuyan Li, Haibo Wang, Fei Gao","doi":"10.1007/s11682-025-01024-7","DOIUrl":"https://doi.org/10.1007/s11682-025-01024-7","url":null,"abstract":"<p><p>Presbycusis is a common disease in the elderly linked to cognitive decline. Studies have shown structural alterations in brain regions associated with hearing and cognitive function in presbycusis patients. However, the neural mechanisms linking brain structure with hearing loss and cognitive impairment remain unclear. This study investigated neuroanatomical alterations associated with auditory and cognitive functions. A total of 67 presbycusis patients and 68 normal-hearing controls underwent magnetic resonance imaging, auditory assessment, and cognitive assessment. Presbycusis patients were divided into presbycusis cognitive preservation (presbycusis-CP) and presbycusis cognitive impairment (presbycusis-CI) subgroups according to Montreal Cognitive Assessment scores. Atrophy of gray matter volume (GMV) was observed in presbycusis patients. The results indicated that GMV of the hippocampus, superior frontal cortex (SFC), and posterior cingulate cortex (PCC) mediated the connection between hearing loss and cognitive impairment. Interestingly, the hippocampus mediated the relationship between the GMV of the SFC and PCC in presbycusis and with the strongest mediating effect (56.14%) in presbycusis-CI patients. Notably, this was not valid in normal-hearing controls and presbycusis-CP patients. Overall, patients with presbycusis, especially presbycusis-CI patients, exhibit a distinct reorganization pattern in auditory and cognitive-related brain areas, with the hippocampus potentially being a key target for presbycusis-related cognitive impairment.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions of white matter in adolescents with internet game disorder: evidence from seed-based d mapping.","authors":"Hao Zheng, Chunyu Dong, Yu Wan, Hailong Shen, Sen Li, Shanling Ji, Jian Cui, Kun Li, Hao Yu, Chuanxin Liu, Cong Zhou","doi":"10.1007/s11682-025-01033-6","DOIUrl":"10.1007/s11682-025-01033-6","url":null,"abstract":"","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary study on changes in volume and functional connectivity of hippocampal subregions in patients with diabetic retinopathy.","authors":"Yaqi Song, Meng Zhu, Weiqi Ji, Zhongru Sun, Liang He, Jinhua Chen, Weizhong Tian, Xiaohong Zhang, Jianguo Xia","doi":"10.1007/s11682-025-01029-2","DOIUrl":"10.1007/s11682-025-01029-2","url":null,"abstract":"<p><p>The aim of this study is to investigate the disparities in volumes of hippocampal subfields and alterations in whole-brain functional connectivity among individuals diagnosed with diabetic retinopathy (DR). This study comprised a total of 32 diabetic patients with retinopathy (DR group, n = 32) and 38 healthy adults (HC group, n = 38), who underwent psychological cognitive testing along with structural and functional magnetic resonance imaging. The FreeSurfer software was utilized for the extraction and computation of hippocampal subfield volumes, as well as the overall volumes of the left and right hippocampus. The volumetric comparisons were conducted by employing independent sample t-tests in SPSS 26.0. The functional connectivity comparisons were subjected to statistical analysis using the Matlab software. Age, education level and grnder were used as control variables, and partial correlation analysis was performed to investigate the relationship between differences in volume and functional connectivity values with psychological cognitive test results and clinical indicators. The volume of the left hippocampal tail and fissure, as well as the right hippocampal C3, C4 and fissure regions in the DR patient group, exhibited significant differences compared to the HC group (P < 0.05, FDR < 0.05). Regions of interest were identified based on the segmented volume differences, and compared to the HC group, enhanced connectivity was observed between the left hippocampal tail and the left caudate nucleus (MNI: x,y, z=-6, 12, 9) and the right caudate nucleus (MNI: x,y, z = 9, 12, 12) in DR patients. Additionally, reduced connectivity was observed between the left hippocampal fissure and the right precentral gyrus (MNI: x, y, z = 57, 0, 45) and the right supplementary motor area (MNI: x, y, z = 9, 3, 60). Partial correlation analysis, with age, education level, and gender as covariates, showed no significant associations between the imaging changes and clinical indicators or cognitive scores. The alterations in hippocampal volume and function observed in patients with DR may potentially underlie their cognitive impairment and sensorimotor deficits, thus suggesting a plausible neuropathological mechanism.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue, monocyte activation, and degree centrality of the thalamus in post-menopausal women living with HIV.","authors":"Kaitlyn Dillon, Judith Lobo, Suresh Pallikkuth, Bonnie Levin, Roger McIntosh","doi":"10.1007/s11682-025-01028-3","DOIUrl":"https://doi.org/10.1007/s11682-025-01028-3","url":null,"abstract":"","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar large-scale network connectivity in Parkinson's disease: associations with emotion, cognition, and aging effects.","authors":"Chentao He, Zhenzhen Chen, Mengfei Cai, Piao Zhang, Hao Li, Xi Chen, Qi Qi, Rui Yang, Yan Li, Zaiyi Liu, Lijuan Wang, Yuhu Zhang","doi":"10.1007/s11682-025-01030-9","DOIUrl":"https://doi.org/10.1007/s11682-025-01030-9","url":null,"abstract":"<p><p>Emerging evidence highlights the cerebellum's involvement in Parkinson's disease (PD), yet its intrinsic functional connectivity with cortical-subcortical networks remains largely unexplored. This study aims to investigate cerebellar functional network alterations in PD and their associations with motor, cognitive, and emotional symptoms, as well as age-related effects. 82 participants with PD (PwPD) and 38 healthy controls (HCs) underwent structural and resting-state functional MRI scans. We conducted volumetric analysis in the cerebellum and examined the involvement of cerebellar functional networks in PD, both within-network and between-network connections regarding cortical-subcortical large-scale networks. Additionally, we explored correlations with motor, cognitive, and emotional symptoms, as well as age-related associations in PwPD. No significant differences in cerebellar volume were observed between PwPD and HCs. PwPD exhibited reduced functional connectivity within the cerebellar network and between the cerebellum (CER) and the salience network (SN) (P < 0.001). Decreased CER-SN connectivity correlated with lower MoCA scores and higher HAMD scores, indicating associations with cognitive impairment and depressive symptoms. Additionally, CER-MTL (medial temporal lobe) connectivity positively correlated with both HAMD and HAMA scores in PwPD. Age-related differences in CER-SN connectivity were significant between PwPD and HCs (P = 0.008). Our study suggests the involvement of cerebellar large-scale functional network connectivity in PD, emphasizing the role of cerebellar functional networks in the emotional and cognitive aspects of PD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion basis spectrum imaging of white matter in schizophrenia and bipolar disorder.","authors":"Daniel Mamah, Aakash Patel, ShingShiun Chen, Yong Wang, Qing Wang","doi":"10.1007/s11682-025-01021-w","DOIUrl":"10.1007/s11682-025-01021-w","url":null,"abstract":"<p><p>Multiple studies point to the role of neuroinflammation in the pathophysiology of schizophrenia (SCZ), however, there have been few in vivo tools for imaging brain inflammation. Diffusion basis spectrum imaging (DBSI) is an advanced diffusion-based MRI method developed to quantitatively assess microstructural alternations relating to neuroinflammation, axonal fiber, and other white matter (WM) pathologies. We acquired one-hour-long high-directional diffusion MRI data from young control (CON, n = 27), schizophrenia (SCZ, n = 21), and bipolar disorder (BPD, n = 21) participants aged 18-30. We applied Tract-based Spatial Statistics (TBSS) to allow whole-brain WM analyses and compare DBSI-derived isotropic and anisotropic diffusion measures between groups. Clinical relationships of DBSI metrics with clinical symptoms were assessed across SCZ and control participants. In SCZ participants, we found a generalized increase in DBSI-derived cellularity (a putative marker of neuroinflammation), a decrease in restricted fiber fraction (a putative marker of apparent axonal density), and an increase in extra-axonal water (a putative marker of vasogenic edema) across several WM tracts. There were only minimal WM abnormalities noted in BPD, mainly in regions of the corpus callosum (increase in DTI-derived RD and extra-axonal water). DBSI metrics showed significant partial correlations with psychosis and mood symptoms across groups. Our findings suggest that SCZ involves generalized white matter neuroinflammation, decreased fiber density, and demyelination, which is not seen in bipolar disorder. Larger studies are needed to identify medication-related effects. DBSI metrics could help identify high-risk groups requiring early interventions to prevent the onset of psychosis and improve outcomes.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining functional, structural, and morphological networks for multimodal classification of developing autistic brains.","authors":"Changchun He, Jesus M Cortes, Yi Ding, Xiaolong Shan, Maoyang Zou, Heng Chen, Huafu Chen, Xianmin Wang, Xujun Duan","doi":"10.1007/s11682-025-01026-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01026-5","url":null,"abstract":"<p><p>Accumulating neuroimaging evidence suggests that abnormal functional and structural brain connectivity plays a cardinal role in the pathophysiology of autism spectrum disorder (ASD). Here, we constructed brain networks of functional, structural, and morphological connectivity using data from functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and structural magnetic resonance imaging (sMRI), respectively. The neuroimaging data from a cohort of 50 individuals with ASD and 47 age-, gender- and handedness-matched TDC (age range: 5-18 years) were selected from the Autism Brain Image Data Exchange database. The combination of the fMRI, sMRI and DTI modalities connectivity features resulted in a classification accuracy of 82.69% for differentiating individuals with ASD from TDC. This accuracy surpassed that of any single modality or combination of fMRI and DTI modalities previously examined. Among the fMRI, sMRI and DTI modalities, the most distinguishing connectivity features were observed in the temporal, parietal, and occipital lobes from the DTI modality, the prefrontal and parietal lobes from the fMRI modality, and the temporal lobe from the sMRI modality. In addition, we also found that these distinguishing connectivity features can predict abnormal social interaction behaviours in ASD. These results highlight the complementary information provided by multimodal approaches, further emphasizing the pivotal role of multimodal connectivity patterns in unravelling the intricate mechanisms involved in the pathophysiology of ASD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional connectivity alterations in post-stroke cognitive impairment: a systematic review.","authors":"Elena Sagues, Francisco Alfaro, Ramón Ramos-Rodríguez, Natalia García-Casares","doi":"10.1007/s11682-025-01013-w","DOIUrl":"https://doi.org/10.1007/s11682-025-01013-w","url":null,"abstract":"<p><p>Post-stroke cognitive impairment is a common and highly disabling multi-domain cognitive decline with unclear pathophysiological mechanisms. Its extent may be predicted by functional neuroimaging techniques, which could enhance our understanding of its underlying pathophysiology. Synthesize the state-of-the-art knowledge on resting-state functional magnetic resonance imaging findings in post-stroke cognitive impairment, their correlation with cognitive performance and the secondary compensatory connectivity changes. We performed a qualitative systematic literature review of reported data of resting-state functional magnetic resonance imaging abnormalities in post-stroke cognitive impairment, consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2024. We selected 23 studies. They reported several key brain areas and network abnormalities associated with post-stroke cognitive impairment compared to controls and non-demented patients. The main areas with decreased functional connectivity were the medial prefrontal cortex, the inferior frontal gyrus, the posterior and anterior cingulate cortex, the precuneus and the hippocampus. The principal network altered was the default mode network, which includes the majority of the brain structures previously mentioned. Additionally, increased functional connectivity in other contralesionally areas may represent maladaptive or compensatory changes post-stroke. Resting-state functional magnetic resonance imaging is a promising tool for studying functional changes associated with post-stroke cognitive impairment. It may enhance our understanding of its pathophysiology and improve selection of suitable period or candidates for cognitive rehabilitation.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered perfusion in the locus coeruleus of patients with chronic migraine: a pilot 3D-PCASL study.","authors":"Jianmei Xiong, Mengqi Liu, Xin Li, Zhiye Chen","doi":"10.1007/s11682-025-01020-x","DOIUrl":"https://doi.org/10.1007/s11682-025-01020-x","url":null,"abstract":"<p><p>Numerous studies have demonstrated that the locus coeruleus (LC) is activated by acute, nociceptive pain and plays an important role in the management of chronic pain. The purpose of this study was to assess the morphology and cerebral blood flow (CBF) changes in the LC of chronic migraine (CM) patients and explore the associations between these changes and the clinical features of these patients via three-dimensional pseudocontinuous arterial spin labelling (3D PCASL) in order to better elucidate the role of the LC in the pathophysiology of CM. Thirteen patients diagnosed with CM at the Department of Neurology, Hainan Hospital of PLA General Hospital, from May 2020 to June 2021 were prospectively included, and fifteen age- and sex-matched normal controls (NCs) were enrolled. All participants underwent psychoneurological assessments and brain structural and 3D PCASL MRI examinations. Brain region volume and CBF alterations were assessed, their associations with clinical scores were analysed, and receiver operating characteristic (ROC) curve analysis was conducted to determine the variables that best differentiated between the groups. No significant differences were found in the total volume of the LC between CM patients and NCs (P > 0.05). Compared with that in the NCs, the CBF of the bilateral LCs was lower in CM patients; the difference on the right side was statistically significant (P = 0.031). Correlation analysis revealed a negative correlation between the CBF of the LC and disease duration (in years). ROC curve analysis revealed that the area under the curve of the CBF of the right LC was 0.749 (95% CI 0.563-0.935), and the optimal cut-off value, sensitivity, and specificity in distinguishing CM patients from NCs were 49.67 ml/100 mg/min, 0.53 and 0.92, respectively. Hypoperfusion of the bilateral LC was observed in CM patients and contributes to the understanding of the pathogenesis of CM. 3D PCASL could serve as a useful tool for diagnosing and assessing CM.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}