Brain Imaging and Behavior最新文献_第3页

Functional brain alterations in COVID-19 patients using resting-state fMRI: a systematic review. 利用静息态 fMRI 观察 COVID-19 患者的大脑功能变化：系统综述。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-30 DOI: 10.1007/s11682-024-00935-1

Siti Maisarah Nasir, Noorazrul Yahya, Hanani Abdul Manan

{"title":"Functional brain alterations in COVID-19 patients using resting-state fMRI: a systematic review.","authors":"Siti Maisarah Nasir, Noorazrul Yahya, Hanani Abdul Manan","doi":"10.1007/s11682-024-00935-1","DOIUrl":"https://doi.org/10.1007/s11682-024-00935-1","url":null,"abstract":"This study systematically reviews the available evidence on resting-state functional magnetic resonance imaging (rs-fMRI) related to neurological symptoms and cognitive declines in COVID-19 patients. We followed PRISMA guidelines and looked up the PubMed, and Scopus databases for articles search on COVID-19 patients with neurological impairments, and functional connectivity alteration using rs-fMRI technique. Articles published between January 1, 2020, and May 31, 2024, are included in this study. The Quality Assessment Tool for Observational Prospective and Cross-Sectional Studies from the National Heart, Lung, and Blood Institute (NHLBI) was used to assess the quality of papers. A total of 15 articles met the inclusion criteria. The result reveals that the most prevalent neurological impairment associated with COVID-19 was cognitive decline, encompassing issues in attention, memory, processing speed, executive functions, language, and visuospatial ability. The brain connectivity results reveal that two brain areas were functionally altered; the prefrontal cortex and parahippocampus. The functional connectivity mainly increased in the frontal, temporal, and anterior piriform cortex, and reduced in the cerebellum, superior orbitofrontal cortex, and middle temporal gyrus, which also correlated with cognitive decline. The findings of neurological symptoms indicate one study reported a Disorder of Consciousness (DoC), and four studies reported COVID-19 patients with olfactory dysfunction. The present study concludes that COVID-19 can alter brain functional connectivity and offers significant insight into how COVID-19 affects the neuronal foundation of cognitive decline and other neurological impairments.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal thalamocortical network dynamics in patients with migraine and its relationship with electroacupuncture treatment response. 偏头痛患者丘脑皮层网络动态异常及其与电针治疗反应的关系

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-28 DOI: 10.1007/s11682-024-00938-y

Shilan Quan, Chenxi Wang, Jia Huang, Shujun Wang, Tianzhe Jia, Jimin Liang, Ling Zhao, Jixin Liu

{"title":"Abnormal thalamocortical network dynamics in patients with migraine and its relationship with electroacupuncture treatment response.","authors":"Shilan Quan, Chenxi Wang, Jia Huang, Shujun Wang, Tianzhe Jia, Jimin Liang, Ling Zhao, Jixin Liu","doi":"10.1007/s11682-024-00938-y","DOIUrl":"https://doi.org/10.1007/s11682-024-00938-y","url":null,"abstract":"Acupuncture is an effective and safe alternative treatment to prevent and treat migraine, but its central analgesic mechanism remains poorly understood. It is believed that the dysfunction of the thalamocortical connectivity network is an important contributor to migraine pathophysiology. This study aimed to investigate the abnormal thalamocortical network dynamics in patients with migraine without aura (MWoA) before and after an 8-week electroacupuncture treatment. A total of 143 patients with MWoA and 100 healthy controls (HC) were included, and resting-state functional magnetic resonance imaging (fMRI) data were acquired. Dynamic functional network connectivity (dFNC) was calculated for each subject. The modulation effect of electroacupuncture on clinical outcomes of migraine, dFNC, and their association were investigated. In our results, dFNC matrices were classified into two clusters (brain states). As compared with the HC, patients with MWoA had a higher proportion of brain states with a strong thalamocortical between-network connection, implying an abnormal balance of the network organization across dFNC brain states. Correlation analysis showed that this abnormality was associated with summarized clinical measurements of migraine. A total of 60 patients were willing to receive an 8-week electroacupuncture treatment, and 24 responders had 50% changes in headache frequency. In electroacupuncture responders, electroacupuncture could change the abnormal thalamocortical connectivities towards a pattern more similar to that of HC. Our findings suggested that electroacupuncture could relieve the symptoms of migraine and has the potential capacity to regulate the abnormal function of the thalamocortical circuits.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging evaluations of olfactory, gustatory, and neurological deficits in patients with long-term sequelae of COVID-19. 对 COVID-19 长期后遗症患者的嗅觉、味觉和神经系统缺陷进行神经影像学评估。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-28 DOI: 10.1007/s11682-024-00936-0

Carla Masala, Michele Porcu, Gianni Orofino, Giovanni Defazio, Ilenia Pinna, Paolo Solla, Tommaso Ercoli, Jasjit S Suri, Giacomo Spinato, Luca Saba

{"title":"Neuroimaging evaluations of olfactory, gustatory, and neurological deficits in patients with long-term sequelae of COVID-19.","authors":"Carla Masala, Michele Porcu, Gianni Orofino, Giovanni Defazio, Ilenia Pinna, Paolo Solla, Tommaso Ercoli, Jasjit S Suri, Giacomo Spinato, Luca Saba","doi":"10.1007/s11682-024-00936-0","DOIUrl":"https://doi.org/10.1007/s11682-024-00936-0","url":null,"abstract":"The World Health Organization indicated that around 36 million of patients in the European Region showed long COVID associated with olfactory and gustatory deficits. The precise mechanism underlying long COVID clinical manifestations is still debated. The aim of this study was to evaluate potential correlations between odor threshold, odor discrimination, odor identification, and the activation of specific brain areas in patients after COVID-19. Sixty subjects, 27 patients (15 women and 12 men) with long COVID and a mean age of 40.6 ± 13.4 years, were compared to 33 age-matched healthy controls (20 women and 13 men) with a mean age of 40.5 ± 9.8 years. Our data showed that patients with long COVID symptoms exhibited a significant decrease in odor threshold, odor discrimination, odor identification, and their sum TDI score compared to age-matched healthy controls. In addition, our results indicated significant correlations between odor discrimination and the increased activation in the right hemisphere, in the frontal pole, and in the superior frontal gyrus. This study indicated that the resting-state fMRI in combination with the objective evaluation of olfactory and gustatory function may be useful for the evaluation of patients with long COVID associated with anosmia and hyposmia.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered structure and functional connection of subcortical gray matter in female patients with classical trigeminal neuralgia. 典型三叉神经痛女性患者皮层下灰质结构和功能连接的改变

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-28 DOI: 10.1007/s11682-024-00943-1

Huiru Li, Yi Lu, Wei Xie, Junjie Ye, Qing Wang, Zhenguang Zhang, Yuanming Jiang, Zongfang Li

{"title":"Altered structure and functional connection of subcortical gray matter in female patients with classical trigeminal neuralgia.","authors":"Huiru Li, Yi Lu, Wei Xie, Junjie Ye, Qing Wang, Zhenguang Zhang, Yuanming Jiang, Zongfang Li","doi":"10.1007/s11682-024-00943-1","DOIUrl":"https://doi.org/10.1007/s11682-024-00943-1","url":null,"abstract":"The etiology of classical trigeminal neuralgia (CTN) is still unclear. A better understanding of the cerebral structural and functional changes in female patients with CTN may provide important novel insights into the pathophysiologic mechanisms of female CTN. A total 37 female CTN patients were included and referred to MRI scans, comprising with 19 left CTN and 18 right CTN patients. We analyzed the volume and shape of subcortical gray matter (GM), and the functional connectivity (FC) between the accumbens nucleus (NAc) and whole brain in right and left CTN patients respectively. We found left CTN patients had a reduced right NAc volume compared to controls, similarly, the right CTN had the decreased volume in the left NAc. Vertex-wise shapes of right NAc in left CTN patients showed significant regional shape deformation on the anterior, medial and ventroposterior aspects, in contrast, left NAc of right CTN patients showed significant regional shape deformation on the anterior and posterior aspect. Furthermore, patients with left CTN showed significantly lower FC between the right NAc and right orbitofrontal cortex than control subjects. The volume of NAc in all CTN was significantly related to the perception of present pain intensity. The CTN might be majorly caused by volume reduction in NAc. A greater understanding of the neurobiological basis of pain-related changes in NAc will provide the knowledge for the development of novel NAc based therapeutic targets for pain management or even prevention in CTN patients.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between large neutral amino acids and white matter hyperintensities in middle-aged adults at varying metabolic risk. 具有不同代谢风险的中年人体内大分子中性氨基酸与白质高密度之间的关系。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-27 DOI: 10.1007/s11682-024-00937-z

Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Hirofumi Tanaka, Andreana P Haley

{"title":"Association between large neutral amino acids and white matter hyperintensities in middle-aged adults at varying metabolic risk.","authors":"Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Hirofumi Tanaka, Andreana P Haley","doi":"10.1007/s11682-024-00937-z","DOIUrl":"10.1007/s11682-024-00937-z","url":null,"abstract":"This investigation delves into the interplay between large neutral amino acids (LNAA) and metabolic syndrome (MetS) in midlife adults, examining their collective influence on brain structure. While LNAA, such as tryptophan and phenylalanine, are known to bolster cognition in youth, these relationships often reverse later in life. Our study hypothesized an earlier reversal of these benefits in middle-aged adults with MetS, potentially signaling premature brain aging. Eighty participants between 40-61 years underwent MetS component quantification, LNAA measurement via high-performance liquid chromatography, and brain imaging to evaluate white matter hyperintensities (WMH) volume and medial temporal lobe (MTL) cortical thickness. Our linear regression analyses, adjusting for sex, age, and education, revealed that phenylalanine levels moderated the relationship between MetS and WMH volume (F(6, 69) = 3.134, p < 0.05, R2 = 0.214), suggesting the brain impact of MetS may be partly due to phenylalanine catabolism byproducts. LNAA metabolites did not significantly modulate the MetS-MTL cortical thickness relationship. These findings suggest that better understanding of the role of phenylalanine in the pathogenesis of cerebrovascular disease in midlife may be essential to developing early interventions to protect cognitive health. Further research is crucial to elucidate the longitudinal influence of LNAA and MetS on brain health, thereby informing strategies to mitigate cognitive decline.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical microstructural alterations in different stages of Parkinson's disease. 帕金森病不同阶段的皮质微结构改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-27 DOI: 10.1007/s11682-024-00931-5

Xueqin Bai, Tao Guo, Xiaojun Guan, Cheng Zhou, Jingjing Wu, Haoting Wu, Xiaocao Liu, Chengqing Wu, Jingwen Chen, Jiaqi Wen, Jianmei Qin, Sijia Tan, Xiaojie DuanMu, Luyan Gu, Ting Gao, Peiyu Huang, Baorong Zhang, Xiaojun Xu, Xiangwu Zheng, Minming Zhang

{"title":"Cortical microstructural alterations in different stages of Parkinson's disease.","authors":"Xueqin Bai, Tao Guo, Xiaojun Guan, Cheng Zhou, Jingjing Wu, Haoting Wu, Xiaocao Liu, Chengqing Wu, Jingwen Chen, Jiaqi Wen, Jianmei Qin, Sijia Tan, Xiaojie DuanMu, Luyan Gu, Ting Gao, Peiyu Huang, Baorong Zhang, Xiaojun Xu, Xiangwu Zheng, Minming Zhang","doi":"10.1007/s11682-024-00931-5","DOIUrl":"https://doi.org/10.1007/s11682-024-00931-5","url":null,"abstract":"To explore the cortical microstructural alterations in Parkinson's disease (PD) at different stages. 149 PD patients and 76 healthy controls were included. PD patients were divided into early stage PD (EPD) (Hoehn-Yahr stage ≤ 2) and moderate-to-late stage PD (MLPD) (Hoehn-Yahr stage ≥ 2.5) according to their Hoehn-Yahr stages. All participants underwent two-shell diffusion MRI and the images were fitted to Neurite Orientation Dispersion and Density Imaging (NODDI) model to obtain the neurite density index (NDI) and orientation dispersion index (ODI) to reflect the cortical microstructure. We used gray matter-based spatial statistics method to compare the voxel-wise cortical NODDI metrics between groups. Partial correlation was used to correlate the NODDI metrics and global composite outcome in PD patients. Compared with healthy controls, EPD patients showed lower ODI in widespread regions, covering bilateral frontal, temporal, parietal and occipital cortices, as well as regional lower NDI in bilateral cingulate and frontal lobes. Compared with healthy controls, MLPD patients showed lower ODI and NDI in more widespread regions. Compared with EPD patients, MLPD patients showed lower ODI in bilateral temporal, parietal and occipital cortices, where the ODI values were negatively correlated with global composite outcome in PD patients. PD patients showed widespread cortical microstructural degeneration, characterized by reduced neurite density and orientation dispersion, and the cortical neuritic microstructure exhibit progressive degeneration during the progression of PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellum and basal ganglia connectivity in isolated REM sleep behaviour disorder and Parkinson's disease: an exploratory study. 孤立快速眼动睡眠行为障碍和帕金森病的小脑和基底神经节连通性：一项探索性研究。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-25 DOI: 10.1007/s11682-024-00939-x

Michael J Firbank, Jacopo Pasquini, Laura Best, Victoria Foster, Hilmar P Sigurdsson, Kirstie N Anderson, George Petrides, David J Brooks, Nicola Pavese

{"title":"Cerebellum and basal ganglia connectivity in isolated REM sleep behaviour disorder and Parkinson's disease: an exploratory study.","authors":"Michael J Firbank, Jacopo Pasquini, Laura Best, Victoria Foster, Hilmar P Sigurdsson, Kirstie N Anderson, George Petrides, David J Brooks, Nicola Pavese","doi":"10.1007/s11682-024-00939-x","DOIUrl":"https://doi.org/10.1007/s11682-024-00939-x","url":null,"abstract":"REM sleep behaviour disorder (RBD) is a parasomnia characterised by dream-enacting behaviour with loss of muscle atonia during REM sleep and is a prodromal feature of α-synucleinopathies like Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Although cortical-to-subcortical connectivity is well-studied in RBD, cerebellar and subcortical nuclei reciprocal connectivity is less established. Nonetheless, it could be relevant since RBD pathology involves brainstem structures with an ascending gradient. In this study, we utilised resting-state functional MRI to investigate 13 people with isolated RBD (iRBD), 17 with Parkinson's disease and 16 healthy controls. We investigated the connectivity between the basal ganglia, thalamus and regions of the cerebellum. The cerebellum was segmented using a functional atlas, defined by a resting-state network-based parcellation, rather than an anatomical one. Controlling for age, we found a significant group difference (F4,82 = 5.47, pFDR = 0.017) in cerebellar-thalamic connectivity, with iRBD significantly lower compared to both control and Parkinson's disease. Specifically, cerebellar areas involved in this connectivity reduction were related to the default mode, language and fronto-parietal resting-state networks. Our findings show functional connectivity abnormalities in subcortical structures that are specific to iRBD and may be relevant from a pathophysiological standpoint. Further studies are needed to investigate how connectivity changes progress over time and whether specific changes predict disease course or phenoconversion.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor impulsivity and spicy food craving: A mediation analysis of insula-based resting state functional connectivity. 运动冲动和对辛辣食物的渴望：基于脑岛静息状态功能连接的中介分析。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-24 DOI: 10.1007/s11682-024-00932-4

Yizhou Zhou, Yong Liu, Chao Yang, Xuemeng Zhang, Rensijing Liu, Hong Chen

{"title":"Motor impulsivity and spicy food craving: A mediation analysis of insula-based resting state functional connectivity.","authors":"Yizhou Zhou, Yong Liu, Chao Yang, Xuemeng Zhang, Rensijing Liu, Hong Chen","doi":"10.1007/s11682-024-00932-4","DOIUrl":"https://doi.org/10.1007/s11682-024-00932-4","url":null,"abstract":"In China, the rate of spicy food consumption is rising, and chili pepper is among the most popular spicy foods consumed nationwide. However, little effort has been made to understand the mechanism behind spicy food craving. This exploratory study aimed to investigate differences in insula-based resting state functional connectivity (rsFC) between spicy food cravers and non-cravers, and the association between rsFC, impulsivity and spicy food craving. A group of extreme cravers (n = 49) and a group of age- and sex-matched non-cravers (n = 46) completed a resting-state fMRI scan, during which participants were instructed to keep their eyes closed, to not think of anything in particular, and to remain awake. Participants completed the Spicy Food Craving Questionnaire, Barratt Impulsiveness Scale, Sensation Seeking Scale and Positive and Negative Affect Schedule, and rated the frequency of spicy food intake. Results revealed increased insula-occipital lobe resting-state functional connectivity in individuals with spicy food cravings, and the positive correlations between insula-middle occipital gyrus rsFC, impulsivity and spicy food craving. Specifically, the insula-middle occipital gyrus rsFC strength mediated the relationship between the motor impulsivity and spicy food craving. It is hoped that our exploratory findings may shed new insights into the neural mechanisms of spicy food craving and motivate further exploration of spicy food craving in diverse contexts and cultures.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive impairment mediates the white matter injury load and gait disorders in subcortical ischemic vascular disease. 认知障碍介导皮层下缺血性血管疾病的白质损伤负荷和步态障碍。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-24 DOI: 10.1007/s11682-024-00941-3

Mengmeng Feng, Ziyang Song, Zheping Zhou, Zhiwei Wu, Mengya Ma, Yuanqing Liu, Yueju Wang, Hui Dai

{"title":"Cognitive impairment mediates the white matter injury load and gait disorders in subcortical ischemic vascular disease.","authors":"Mengmeng Feng, Ziyang Song, Zheping Zhou, Zhiwei Wu, Mengya Ma, Yuanqing Liu, Yueju Wang, Hui Dai","doi":"10.1007/s11682-024-00941-3","DOIUrl":"https://doi.org/10.1007/s11682-024-00941-3","url":null,"abstract":"Gait disorders are common in patients with subcortical ischemic vascular disease (SIVD). We aim to explore the impact of white matter (WM) damage on gait disorders in SIVD. 21 SIVD patients and 20 normal controls (NC) were included in the study. Montreal Cognitive Assessment (MoCA) was used to evaluate general cognition, while Speed-Accuracy Trade-Off (SAT) was used to assess executive function. Gait velocity, cadence, and stride length were measured. Diffusion Tensor Imaging (DTI) data were analyzed using Tract-Based Spatial Statistics (TBSS) and Peak Width of Skeletonized Mean Diffusivity (PSMD). The relationships among WM damage, gait disorders, and cognitive function were examined through mediation analysis. SIVD scored lower than NC in MoCA and SAT tests (P < 0.001). Gait velocity and stride length were decreased in SIVD. SIVD had lower PSMD (P < 0.001). PSMD correlated with gait parameters, which were totally mediated by MoCA and partially mediated by SAT. The fractional anisotropy (FA) and mean diffusivity (MD) of the genu of the corpus callosum (GCC) and body of CC (BCC) were correlated with gait parameters. The FA of the bilateral anterior corona radiata (ACR) was positively correlated with gait parameters, while the MD of the bilateral superior corona radiata (SCR), bilateral superior longitudinal fasciculus (SLF), and left external capsule (EC) were negatively correlated with them (P < 0.05). Gait impairments in SIVD were associated with cognitive deficits. Cognitive impairment mediated the WM damage and gait disorders. The microstructural alterations of CC, SLF, EC, and CR may be related to changes in gait.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A longitudinal multimodal MRI study of the visual network in postoperative delirium 术后谵妄视觉网络的纵向多模态磁共振成像研究

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-19 DOI: 10.1007/s11682-024-00929-z

Guobin Zhang, Beier Qi, Haoyi Li, Xiaokang Zhang, Jian Chen, Haiyun Li, Bin Jing, Huawei Huang

{"title":"A longitudinal multimodal MRI study of the visual network in postoperative delirium","authors":"Guobin Zhang, Beier Qi, Haoyi Li, Xiaokang Zhang, Jian Chen, Haiyun Li, Bin Jing, Huawei Huang","doi":"10.1007/s11682-024-00929-z","DOIUrl":"https://doi.org/10.1007/s11682-024-00929-z","url":null,"abstract":"Although structural and functional damage to the brain is considered to be an important neurobiological mechanism of postoperative delirium (POD), alterations in the visual cortical network related to this vulnerability have not yet been determined. In this study, we investigated the impact of alterations in the visual network (VN), as measured by structural and functional magnetic resonance imaging (MRI), on the development of POD. Thirty-six adult patients with frontal glioma who underwent elective craniotomy were recruited. The primary outcome was POD 1–7 days after surgery, as assessed by the Confusion Assessment Method. Cognition before surgery was measured by a battery of neuropsychological tests. Then, we evaluated preoperative and postoperative gray matter volume (GMV) and functional connectivity (FC) alterations by voxel-based morphometry and resting-state functional MRI (rs-fMRI) between the POD and non-POD groups. Multiple logistic regression models were used to investigate the associations between neuroimaging biomarkers and the occurrence of POD. Compared to those in the non-POD group, a decreased GMV in the fusiform gyrus (0.181 [0.018] vs. 0.207 [0.022], FDRp = 0.001) and decreased FC between the fusiform gyrus and VN (0.351 [0.153] vs. 0.610 [0.197], GFRp < 0.001) were observed preoperatively in the POD group, and increased FC between the fusiform gyrus and ventral attentional network (0.538 [0.180] vs. 0.452 [0.184], GFRp = < 0.001) was observed postoperatively in the POD group. According to our multiple logistic regression analysis, age (Odds ratio [OR]: 1.141 [1.015 to 1.282], P = 0.03) and preoperative fusiform-VN FC (OR 0.001 [0.001 to 0.067], P = 0.01) were significantly related to risk of POD. Our findings suggested that preoperative functional disconnectivity between fusiform and VN might be highly involved in the development of POD. These findings may allow for the discovery of additional underlying mechanisms.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0