Brain Imaging and Behavior最新文献

{"title":"Enhancing reproducibility in neuroimaging with containerized archival.","authors":"Michael E Kim, Praitayini Kanakaraj, Yihao Liu, Trent Schwartz, Zhiyuan Li, Nancy R Newlin, Chenyu Gao, Kurt G Schilling, Shunxing Bao, Baxter P Rogers, Bennett A Landman, Karthik Ramadass","doi":"10.1007/s11682-026-01191-1","DOIUrl":"10.1007/s11682-026-01191-1","url":null,"abstract":"<p><p>Ensuring reproducibility in scientific research is crucial for validating findings, advancing knowledge, and fostering trust within the scientific community. Containerization of code is a widespread practice to help ensure reproducibility in neuroimaging research. However, there exists no universal method of sharing containers, nor is it feasible to broadly enforce rules due to the diversity of research practices. We posit that container sharing should include 1.) public availability, 2.) self-contained documentation, and 3.) procedures to ensure consistency of the container and its expected outputs. We demonstrate an approach for publicly releasing three separate containers using Zenodo. Our proposed method fulfills the design criteria for container sharing while incurring minimal overhead. As there are several tools available to distribute and maintain containers already, we discuss available alternatives.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal resting-state functional connectivity in anhedonia: A systematic review and meta-analysis.","authors":"Xuezhen Zhang, Xinyan Rong, Shiying Wang, Chengfeng Chen, Bin Zhang","doi":"10.1007/s11682-026-01193-z","DOIUrl":"10.1007/s11682-026-01193-z","url":null,"abstract":"<p><p>Anhedonia is a treatment-resistant symptom of major depressive disorder and has prompted neuroimaging studies aimed at clarifying its neural basis. However, findings from seed-based resting-state functional connectivity (rsFC) studies remain inconsistent. We conducted a whole-brain meta-analysis to synthesize rsFC alterations associated with anhedonia. PubMed, Web of Science, and Scopus were searched up to June 14, 2026. Two researchers independently screened eligible studies and analyzed anhedonia-related rsFC. Subgroup analyses, jackknife sensitivity analyses, meta-regression, and publication-bias assessments were performed to evaluate the robustness of the findings. Greater anhedonia severity was associated with stronger NAcc connectivity with the right anterior cingulate cortex, left insula, left middle occipital gyrus, corpus callosum, and left anterior thalamic projections and with weaker NAcc connectivity with the right medial superior frontal gyrus, left caudate nucleus, left orbitofrontal cortex, and left middle frontal gyrus. Greater anhedonia severity was also associated with stronger VC connectivity with the right angular gyrus and weaker VC connectivity with the right cuneus and left calcarine fissure. Subgroup analyses yielded patterns broadly consistent with the main analysis. Meta-regression analyses showed no significant moderating effects of age or sex, and sensitivity analyses supported the stability of the findings. Anhedonia was associated with convergent NAcc- and VC-centered rsFC alterations across reward, salience, and sensory regions. These findings support a distributed circuit-level model of anhedonia and may inform future research on symptom-targeted neuromodulation.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered amplitude of low-frequency fluctuations in herpes simplex encephalitis: a resting-state fMRI study and associations with anxiety.","authors":"Hongxia Bai, Qi Zhou, Hui Li, Cailing Zhao, Ying Bai, Yangli Yu, Jueyue Yan, Lingli Lou","doi":"10.1007/s11682-026-01192-0","DOIUrl":"10.1007/s11682-026-01192-0","url":null,"abstract":"<p><p>To investigate alterations in the amplitude of low-frequency fluctuations (ALFF) in herpes simplex encephalitis (HSE) patients using resting-state functional magnetic resonance imaging (rs-fMRI) and evaluate their associations with anxiety symptoms. In this single-center cohort study, 45 HSE patients and 46 healthy controls (HC) were recruited from the First Affiliated Hospital of Zhejiang University School of Medicine, China. HSE was confirmed by clinical features and positive herpes simplex virus (HSV) DNA in cerebrospinal fluid via polymerase chain reaction. Participants underwent rs-fMRI scans within one week of ICU admission. ALFF was calculated using REST software; group differences were assessed with voxel-wise two-sample t-tests (covariates: age, sex, education, framewise displacement; whole-brain voxel-wise FDR-corrected P < 0.05) and validated nonparametrically. Associations between ALFF and anxiety (Hamilton Anxiety Rating Scale, HAMA) were examined via general linear models, controlling for age, sex, hypertension, and education, with Spearman's correlations for robustness. Compared to HC, HSE patients exhibited increased ALFF in the left precuneus and right putamen, alongside decreased ALFF in the right angular gyrus and right caudate nucleus (whole-brain voxel-wise FDR-corrected P < 0.05). These changes correlated significantly with HAMA scores: positive associations in hyperactive regions (left precuneus: β = 0.558, 95% CI: 0.312 to 0.805, p < 0.001; right putamen: β = 0.511, 95% CI: 0.254 to 0.768, p < 0.001) and negative associations in hypoactive regions (right angular gyrus: β = -0.517, 95% CI: -0.773 to -0.261, p < 0.001; right caudate: β = -0.556, 95% CI: -0.804 to -0.307, p < 0.001). No significant correlations emerged with depression scores (Hamilton Depression Rating Scale). HSE induces region-specific ALFF disruptions, characterized by hyperactivity in the precuneus and putamen together with hypoactivity in the angular gyrus and caudate within limbic-paralimbic networks. These alterations show strong associations with anxiety severity, suggesting ALFF as a potential noninvasive biomarker for HSE-related functional and neuropsychiatric impairments. Larger longitudinal studies are warranted to elucidate underlying mechanisms and therapeutic implications.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially constrained ICA from a language task enables sensorimotor network extraction in patients with space-occupying brain lesions.","authors":"Eva Calderón-Rubio, Víctor Costumero, Vicente Belloch, César Ávila","doi":"10.1007/s11682-026-01183-1","DOIUrl":"10.1007/s11682-026-01183-1","url":null,"abstract":"<p><p>Although resting-state fMRI is a promising alternative to task-fMRI in presurgical mapping, protocols to simultaneously assess language lateralization and sensorimotor networks within a single acquisition remain limited. To evaluate the feasibility of using connectivity analysis derived from a language fMRI task to assess language lateralization and extract the sensorimotor network in presurgical patients with space-occupying lesions. In a retrospective study, 40 presurgical patients underwent a verb generation task (VGT) and a hand motor task (HMT). Single-subject spatially-constrained ICA (scICA) was performed on VGT scans to extract sensorimotor components. Sensitivity, specificity and Dice coefficient between scICA-derived scans and HMT activation maps were calculated. The effects of different variables were analyzed using ANOVA. Forty patients (mean age, 40.50 ± 13.99; 21 men) were included. Sensorimotor components could be extracted in all patients within the predefined constrained scICA framework. Using HMT activation as comparative reference, mean ipsilesional voxelwise sensitivity, specificity and Dice coefficient of scICA-derived maps were 78%, 75% and 36%, respectively. No significant differences were found between ipsilesional and contralesional hemispheres in sensitivity or specificity. Exploratory analyses suggested higher sensitivity values in the right contralesional hemisphere, higher magnetic field strength, and typical language lateralization, although most effects did not survive FDR correction. Our study supports the feasibility of extracting sensorimotor-related networks from a language task while simultaneously determining language lateralization in patients with space-occupying lesions. This approach may provide complementary presurgical information, potentially reducing acquisition time. Further validation using direct cortical stimulation and larger prospective cohorts is warranted.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cortical morphology of cingulate cortex and microarchitecture of cingulum bundle correlate with cancer pain and anxiety in lung cancer patients.","authors":"Lin Tang, Xiaosong Lan, Xiaoyu Zhou, Yu Tang, Jiahui Zheng, Junhao Huang, Yong Tan, Jing Zhang, Hong Yu, Meng Lin, Hua Lan, Xinying Ren, Xunrong Luo, Jiuquan Zhang, Daihong Liu","doi":"10.1007/s11682-026-01189-9","DOIUrl":"10.1007/s11682-026-01189-9","url":null,"abstract":"<p><p>The cingulate cortex (CC) and cingulum bundle (CB) are key structures involved in pain processing. Thus, we explored the correlations between cortical morphometry of the CC, white matter integrity of the CB, and pain-related assessments in lung cancer patients with cancer pain (CP+). Structural and diffusion spectrum imaging, along with emotion and pain-related assessments, were collected from 45 CP+ patients, 47 lung cancer patients without pain (CP-), and 35 healthy controls (HC). Cortical morphometry and tract-based automatic analysis evaluated the CC and CB. One-way ANOVA revealed significant group differences in sulcal depth (SD) within the CC, as well as in fractional anisotropy (FA) and radial diffusivity (RD) within the CB. Post-hoc tests indicated that the CP+ group had greater SD than the CP- group, and smaller FA as well as greater RD than both the CP - and HC groups. In the CP+ group, RD of the CB was positively correlated with SD of the CC, and the anxiety score was positively correlated with RD of the CB and SD of the CC. In the HC group, the anxiety score was negatively correlated with SD of the CC. This study revealed distinct patterns of structural alterations across the three groups. Differences in both CB and CC structures were observed in CP+ relative to CP - and HC groups, were interrelated, and were associated with anxiety. These findings highlight the significant contribution of CC and CB in cancer pain processing, while also serving as potential biomarkers for negative emotion.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired white matter functional networks topology changed with white matter hyperintensities burden and relationship to cognition.","authors":"Peipei Wang, Weizhao Lu, Jingjuan Wang, Yi Xing, Jie Lu","doi":"10.1007/s11682-026-01188-w","DOIUrl":"10.1007/s11682-026-01188-w","url":null,"abstract":"<p><p>We aimed to investigate the topology alterations of white matter functional networks (WMFNs) associated with varying white matter hyperintensities (WMH) burden, and assess the relationship between topological changes of WMFNs and cognitive function in the individuals with moderate to severe WMH (m/sWMH). Fifty-four cognitively unimpaired individuals were enrolled and stratified into two groups: 26 with m/sWMH and 28 with mild WMH (mWMH). We used graph theory analysis to investigate the global and nodal topological alteration between two groups and to examine the association between WMFNs topological alterations and cognition. The results demonstrated that, compared to the mWMH group, the m/sWMH group exhibited alterations of global and nodal properties, including decreased clustering coefficient (Cp) and shortest path length (Lp), decreased nodal clustering coefficient (Ncp), increased nodal efficiency (Ne), as well as mixed increases and decreases in nodal degree centrality (Dc) and betweenness centrality (Bc). These alterations mainly occurred in the body of corpus callosum, left sagittal stratum (SS) (including the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus, ILF and IFOF), the anterior limb of the internal capsule, cingulate gyrus, and inferior longitudinal fasciculus. The Pearson correlation analysis revealed that nodal properties (Ncp and Dc) in SS (including ILF and IFOF) were associated with cognitive scores in the m/sWMH group. Increased WMH burden may lead to the disintegration of WMFNs topology, which was closely associated with cognitive dysfunction (global cognitive function, attention and processing speed). The SS may be a biomarker for cognitive impairment in individuals with m/sWMH.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Associations of cerebral blood flow and white matter hyperintensities with tau and amyloid-beta across the Alzheimer's disease spectrum.","authors":"Keshuo Lin, Perminder S Sachdev, Jiyang Jiang","doi":"10.1007/s11682-026-01187-x","DOIUrl":"10.1007/s11682-026-01187-x","url":null,"abstract":"<p><p>Although the associations between cerebrovascular dysfunctions and Alzheimer's disease are increasingly appreciated, the relationship of cerebral blood flow and white matter hyperintensities with tau and amyloid-β pathology remains unclear, particularly in the longitudinal context. This study investigated cross-sectional and longitudinal associations of cerebral blood flow and white matter hyperintensities with tau and amyloid-β pathology using multimodal imaging and blood biomarkers in 179 participants from the ADNI3 cohort. Participants underwent structural (T1-weighted, T2-weighted FLAIR) and arterial spin labelling perfusion MRI, tau and amyloid-β PET, and plasma assay tests for amyloid-β 42, amyloid-β 40, and phosphorylated tau-217. Tau from PET was negatively associated with cerebral blood flow both cross-sectionally and longitudinally in the posterior brain, independent of amyloid-β quantified from PET. Higher white matter hyperintensities volumes were associated with higher levels of tau and amyloid-β at baseline, but the associations were significantly attenuated after further adjusting for amyloid-β and tau, respectively. Plasma amyloid-β 42/40 ratio was negatively associated with white matter hyperintensity volumes both cross-sectionally and longitudinally. In conclusion, tau pathology showed spatially specific associations with cerebral hypoperfusion, independent of amyloid-β, particularly in posterior regions. The attenuation of associations of white matter hyperintensities with amyloid-β and tau after adjustment may reflect shared disease-related variance rather than distinct independent effects.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aging on the mechanisms of dynamic integration between the default mode network and other brain networks: evidence based on fMRI data with natural stimulation.","authors":"Fengzhu Sun, Xinxin Li, Yajun Shi, Qing Jiao, Dong Cui, Jinpeng Niu, Yongxin Guo, Li Dong, Weifang Cao","doi":"10.1007/s11682-026-01190-2","DOIUrl":"10.1007/s11682-026-01190-2","url":null,"abstract":"<p><p>Cognitive decline during aging affects daily life in older adults and is associated with altered functional connectivity (FC) between brain networks. However, the dynamic functional network connectivity (dFNC) alterations among brain networks in healthy older adults in response to natural stimuli are unclear. The present study included functional magnetic resonance imaging data of 217 healthy subjects from the Cambridge Centre for Aging and Neuroscience in the movie-watching state to analyze brain networks' dFNC and investigate the relationship between dynamic temporal metrics and cognition. Seven brain networks were obtained using independent component analysis. Four dFNC states were obtained in young and older groups, and connectivity between the salience network and the cerebellum decreased in state 3 in older adults compared to young adults. Older adults spent less time in the strong FC state 2, which was significantly associated with cognition, suggesting that integration across brain networks contributes to the execution of cognitive tasks. In conclusion, using a naturalistic viewing paradigm, this study provides novel evidence that healthy aging is associated with altered spatiotemporal dynamics of large-scale brain networks. Specifically, we identified reduced connectivity between the salience network and cerebellum in older adults and found that the diminished persistence of a key dFNC state (State 2) directly correlates with cognitive performance. These findings offer new insights into the neural mechanisms of cognitive aging by highlighting the critical role of dynamic inter-network integration.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the complex relationship between vestibular symptoms and migraine: a resting‑state functional MRI study.","authors":"Lin Han, Xing Xiong, Jiajie Lu, Kai Zhang, Jun Ke, Hongru Zhao","doi":"10.1007/s11682-026-01185-z","DOIUrl":"10.1007/s11682-026-01185-z","url":null,"abstract":"<p><p>The aim of this study was to examine the temporal sequence of the appearance of vestibular symptoms and migraine, as well as whether they coexist or not, while assessing their influence on cerebral functional activity. The present investigation is a cross-sectional study. This study included 69 participants from the outpatient headache unit at our hospital who were divided into six groups: 33 patients with vestibular migraine (VM) (12 the onset of migraine was earlier than vertigo, 10 the onset of vertigo was earlier than migraine, 11 vertigo was accompanied with migraine), 9 patients with benign recurrent vertigo (BRV), 14 patients with migraine without aura (MoA), and 13 healthy controls. We compared the differences in spontaneous cerebral functional activity between groups, and used the bilateral thalamus as a seed point to analyze its functional connectivity with the whole brain. The relationship between changed cerebral functional activity and clinical features was compared. We have observed variations in the spontaneous functional activity of the right middle and inferior frontal gyrus among individuals in each group, as well as discrepancies in the functional connectivity of the right superior frontal gyrus with the bilateral thalamus. The severity of vertigo disability exhibits a negative correlation with the functional activity in the right inferior frontal gyrus, while the duration of vertigo demonstrates a positive correlation with the functional activity in the right inferior frontal gyrus. Furthermore, the severity of migraine disability displays a negative correlation with the functional connectivity between the bilateral thalamus and the right superior frontal gyrus. In patients with VM, the temporal relationship between vestibular symptoms and migraine did not have any impact on cerebral functional activity. The functional activity of the right middle and inferior frontal gyrus may be influenced by vestibular stimulation, while headache stimulation could potentially modify the functional connectivity between the bilateral thalamus and the right superior frontal gyrus. These findings suggest that VM may be considered as a distinct disease entity.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing brain structural and functional abnormalities in borderline personality disorder by seed-based d mapping approach.","authors":"Wanru Qiu, Sen Li, Aoxue Zhang, Hao Yu, Jian Cui, Yinghong Xu, Liangliang Ping, Hao Zheng, Chunyu Dong, Kun Li, Cong Zhou","doi":"10.1007/s11682-026-01182-2","DOIUrl":"10.1007/s11682-026-01182-2","url":null,"abstract":"<p><p>Borderline personality disorder (BPD) is a mental disorder characterized by extreme instability in mood, interpersonal relationships, self-image, and behavioral patterns. Its core symptoms include intense mood swings, strained interpersonal relationships, disturbed self-identity, impulsive behaviors, and cognitive and perceptual abnormalities. The etiology of BPD is complex, involving genetic, neurobiological, and psychosocial factors. Among neurobiological factors, neuroimaging studies have consistently reported inconsistent findings regarding amygdala volume in BPD patients-some MRI studies demonstrate a 15% increase, while others show a reduction. Such discrepancies may reflect the impact of heterogeneous patient populations, comorbidities, or differences in imaging protocols. Notably, structural and functional abnormalities in BPD are not limited to the amygdala but also involve multiple brain regions, including the prefrontal cortex, hippocampus, anterior cingulate cortex, and insula, which collectively contribute to impaired emotion regulation, interpersonal dysfunction, and other core symptoms. A systematic search was conducted on studies investigating brain neuroimaging differences between BPD patients and healthy controls (HC). Studies meeting the inclusion criteria were selected, and coordinate-based meta-analysis (CBMA) of brain structural and functional changes was performed using seed-based d mapping (SDM) software to explore potential abnormal brain structures and functions in BPD patients. After screening, a total of 26 studies were included. By integrating meta-analytic findings from four neuroimaging modalities-diffusion tensor imaging (DTI), structural magnetic resonance imaging (sMRI), functional magnetic resonance imaging (fMRI), and resting-state functional magnetic resonance imaging (rs-fMRI)-this study systematically summarized the characteristic changes in brain structure and function in BPD patients. Study results demonstrated that the neurobiological basis of BPD primarily involves structural and functional dysregulation of the frontolimbic system, particularly in brain regions linked to core mental functions like emotion regulation, self-cognition, and impulse control.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}