Renren Li, Weixin Xiao, Zengmai Xie, Jing Ma, Xiaoran Zheng, Jiaxin Yan, Xiaochen Zhang, Zhiyu Nie, Yunxia Li
{"title":"The hidden burden: cerebral small vessel disease and cognitive reappraisal failure in memory clinic older adults.","authors":"Renren Li, Weixin Xiao, Zengmai Xie, Jing Ma, Xiaoran Zheng, Jiaxin Yan, Xiaochen Zhang, Zhiyu Nie, Yunxia Li","doi":"10.1007/s11682-025-01018-5","DOIUrl":"https://doi.org/10.1007/s11682-025-01018-5","url":null,"abstract":"<p><p>Emotion regulation is a vital life skill, and cognitive reappraisal (CR) is the most effective emotion regulation strategy, which plays a key role in healthy aging. In memory clinic patients, problems with emotion regulation difficulties and cognitive impairment are very common, often accompanied by signs of cerebral small vessel disease (CSVD) on their magnetic resonance imaging (MRI). Is there a correlation among cognitive reappraisal failure, cognitive impairment, and CSVD in these older adults? This study aims to investigate the question. A standardized emotion regulation task was used to measure CR ability. A total of 170 older adults were included in statistical analysis, of which 78 were considered as cognitive reappraisal failure (CR-Failure). All participants completed the emotion regulation task, neuropsychiatric assessments, and MRI scans, with traditional CSVD markers being evaluated. Our analysis indicated that CR ability is negatively correlated with scores on the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Additionally, logical memory and executive function are significant factors in CR utilization. A higher burden of CSVD or presence of cognitive impairment is an independent risk factor for cognitive reappraisal failure in memory clinic older adults. Furthermore, cognitive impairment significantly mediates the relationship between greater CSVD burden and CR failure.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"White matter microstructural alterations and brain metabolism distributions in Parkinson's disease.","authors":"Mengjiao Wang, Yansong Liu, Wei Han, Yifeng Yang, Yuying Jiao, Yujie Hu, Yang Yang, Linhan Zhang, Yangyang Wang, Peng Fu, Changjiu Zhao","doi":"10.1007/s11682-025-01023-8","DOIUrl":"https://doi.org/10.1007/s11682-025-01023-8","url":null,"abstract":"<p><p>This study aimed to use simultaneous <sup>18</sup>F-FDG PET/MRI based on Automated Fiber Quantification (AFQ) to determine whether there is a relationship between white matter microstructure changes and glucose metabolism distribution in PD. The study involved 38 subjects, including 23 parkinson's disease (PD) patients and 15 age and sex-matched healthy controls (HC). Primary clinical data and cognitive assessments were collected. All subjects underwent a simultaneous <sup>18</sup>F-FDG PET/MRI scan. AFQ was utilized to calculate tract-wise diffusion properties of 20 major white matter tracts. PD patients showed reduced mean Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores compared to HC subjects (P < 0.05). PD patients showed higher mean diffusivity (MD) (P = 0.047) and axial diffusivity (AD) (P = 0.02) along the right corticospinal tract (CST) compared to HC. The microstructural change of CST was mainly located in the parietal part (node 67-100). Compared to HC, PD patients had FDG hypermetabolism in the right paracentral lobule (P = 0.0204) and bilateral putamen (left: P = 0.0075; right: P = 0.0155) and hypometabolism in the right calcarine (P = 0.0489). Hypermetabolism was found in the right paracentral lobule, which connects with the cortex of the right CST, and positively correlated with MD (r = 0.612, P < 0.001) and AD (r = 0.516, P < 0.001). We observed microstructural changes and glucose metabolism distribution characteristics in PD patients. These results may provide imaging evidence for studying the pathology of PD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinaya Hari, Nancy E Mayo, Marie-Josee Brouillette, MaryAnn Noonan, Lesley K Fellows
{"title":"The relationship between social network size and brain structure in older adults living with HIV.","authors":"Vinaya Hari, Nancy E Mayo, Marie-Josee Brouillette, MaryAnn Noonan, Lesley K Fellows","doi":"10.1007/s11682-025-00995-x","DOIUrl":"10.1007/s11682-025-00995-x","url":null,"abstract":"<p><p>The social brain hypothesis suggests that primate brains evolved to manage social group complexities. While chronic HIV infection is associated with both structural brain changes and social exclusion, the possibility that social experience may contribute to brain changes has not been studied in this population. Here, we aimed to estimate the direction and strength of the relationship between gray matter volume and social network size in older people living with HIV in Canada. Fifty-eight HIV + participants (3 women) from the Positive Brain Health Now cohort underwent structural brain imaging and reported the size of their social network. We tested the relationship between social network size and gray matter volume in key brain regions previously identified in healthy older adults. Negative correlations were observed between social network size and gray matter volume in all regions of interest, adjusting for age, education, and total intracranial volume. The strongest correlation was in the left anterior cingulate cortex. We found evidence that social network size is related to gray matter volume in brain regions involved in social behavior among older people, mostly men, with longstanding HIV infection. However, the direction of this effect was opposite to that predicted. This echoes some previous work in healthy male samples. These findings suggest the need to consider social as well as biological variables in studying the brain impacts of living with HIV. Further work is needed to clarify which social variables have the greatest influence, and how they affect the brain.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"647-654"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disruptions of resting-state functional connectivity in post-stroke motor dysfunctions: a meta-analysis.","authors":"Tingting Zhu, Jing Chen, Yanting Du, Tongyue Li, Xize Jia, Yating Lv","doi":"10.1007/s11682-025-00977-z","DOIUrl":"10.1007/s11682-025-00977-z","url":null,"abstract":"<p><p>This study aims to unravel the consistent abnormalities in functional connectivity (FC) with the primary motor cortex (M1) for post-stroke motor dysfunctions and the dynamic shifts of FC across distinct phases (acute/subacute/chronic) following stroke onset. Eleven studies with 269 stroke patients and 257 healthy controls (HCs) were included after screening articles in PubMed, Web of Science, and Embase. Voxel-wise meta-analysis and subgroup analysis on three phases after stroke onset were applied using the anisotropic effect size-signed differential mapping toolbox. Additionally, a M1-seeded FC analysis from an independent dataset with 29 stroke patients and 40 HCs was applied to validate the results of the meta-analyses. The abnormal connectivity with M1 in patients with post-stroke motor dysfunctions extended beyond motor-related regions to non-motor domains. A consistent interhemispheric connectivity reduction between M1 and motor-related regions emerged as a hallmark, persisting across different phases after stroke onset. These alterations were largely replicable through validation analysis. Our findings indicated the imbalance of connectivity in patients with post-stroke motor dysfunctions.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"771-784"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yongming Tan, Hao Wang, Huifang Du, Yongjie Zhou, Mengqian Li, Laichang He
{"title":"Altered cerebellar subregion functional connectivity and structure in patients with pediatric bipolar depression.","authors":"Yongming Tan, Hao Wang, Huifang Du, Yongjie Zhou, Mengqian Li, Laichang He","doi":"10.1007/s11682-025-00997-9","DOIUrl":"10.1007/s11682-025-00997-9","url":null,"abstract":"<p><p>To explore the structural and functional changes of Cerebellar Subregion in patients with pediatric bipolar disorder (PBD) patients and its clinical significance by using multimodal magnetic resonance imaging, so as to further explore the specific role of the cerebellum in PBD. This study included 48 pediatric patients with bipolar disorder (PBD) in the depressive phase from the outpatient clinic of the Department of Psychosomatic Medicine of the First Affiliated Hospital of Nanchang University. 22 healthy controls (HCs) matched for gender, age, handedness and education level were chosen from the community as the control group. All subjects underwent 3.0T resting-state functional magnetic resonance imaging (rs-fMRI) scans and completed clinical scales, including the Hamilton Depression Scale (HAMD) and Young Mania Rating Scale (YMRS). The cerebellum was categorized into 34 distinct subregions (R17, L17) based on SUIT and designated as seed points to perform whole-brain functional connectivity (FC). Group differences in categorical variables were assessed using the chi-square test, while continuous variables were compared employing the two-sample t-test. Correlations between FC and clinical parameters were analyzed for differential brain intervals. Compared with HCs, PBD patients in the depressive phase showed reduced FC between the left cerebellar lobules I-IV and the occipital inferior lobe (Occipital_Inf_L), cerebellar vermis VIIIa, and VIIIb; decreased FC between cerebellar cerebellar vermis VI and the frontal inferior orbital gyrus (Frontal_Inf_Orb_L), as well as the right cerebellar Crus 1; reduced FC between the left cerebellar Crus I and the dentate nucleus; decreased FC between cerebellar vermis VIIIa and the left superior frontal gyrus; reduced FC between the right cerebellar lobule IX and the right lingual gyrus; lowered FC between the left dentate and the dorsolateral prefrontal cortex, and the left lingual gyrus; FC between the left fastigial nucleus and the right cerebellar X decreased. Depressive phase of PBD patients exhibit altered functional connectivity within various subregions of the cerebellum, suggesting that the cerebellum is involved in central neural reorganization in PBD, which may be instructive for the understanding of central mechanisms and its future diagnostic and therapeutic target development.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"655-665"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sajina Rodríguez, Estefanía Hernández-Martín, Julio Plata-Bello
{"title":"Biographical information influences on facial attractiveness judgment.","authors":"Sajina Rodríguez, Estefanía Hernández-Martín, Julio Plata-Bello","doi":"10.1007/s11682-025-01005-w","DOIUrl":"10.1007/s11682-025-01005-w","url":null,"abstract":"<p><p>In the realm of social cognition, facial perception is crucial, particularly in assessing facial attractiveness. This study investigated how biographical information impacts such evaluations. Two experiments were conducted: the first had participants rate 108 faces with and without biographical details, including occupation, psychiatric history, and politics. The second used fMRI to identify brain regions reacting differently with biographical information. Results showed that 31.48% of cases exhibited significant variations in facial evaluations when biographical information was introduced. The fMRI experiment highlighted heightened activity in the left Inferior Frontal Gyrus (IFG) and the left Middle Temporal Gyrus (MTG) when assessing facial attractiveness with biographical information, especially related to occupation or psychiatric history as opposed to politics. In summary, incorporating biographical information can substantially alter perceptions of facial attractiveness, engaging specific brain regions like the left IFG and left MTG. The results of this study could have significant implications for the understanding of social cognition and, among other aspects, for the destigmatization of personal histories in the field of mental health.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"746-758"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Altered functional connectivity within and between resting-state networks in ulcerative colitis.","authors":"Yanjun Ren, Kaizhong Xue, Huijuan Xu, Lijie Hao, Quchuan Zhao, Tianyu Chi, Hongwei Yang, Xiaojing Zhao, Defeng Tian, Huihong Zhai, Jie Lu","doi":"10.1007/s11682-025-01001-0","DOIUrl":"10.1007/s11682-025-01001-0","url":null,"abstract":"<p><p>Patients with ulcerative colitis (UC) often exhibit affective disorders, such as depression and anxiety. The underlying neurological mechanisms of these symptoms, however, remain poorly understood. This study aimed to explore alterations in functional connectivity (FC) both within and between resting-state networks (RSNs) in individuals with ulcerative colitis. Twelve meaningful RSNs were identified from 22 ulcerative colitis patients and 23 healthy controls using independent component analysis of functional magnetic resonance imaging data. Correlation analyses were performed between clinical indices, neuropsychological assessments and neuroimaging data. Compared with healthy controls, UC patients showed increased intranetwork FC, mainly located in the right temporal pole, orbitofrontal cortex, and left superior temporal and Rolandic opercular cortices within the auditory network. Increased intranetwork FC in the Rolandic opercular cortex was also observed in UC patients during remission phase, while no significant alterations were detected in patients with active-phase UC. In addition, UC patients exhibited increased connectivity between the dorsal attention and the left frontoparietal network, as well as between the anterior default mode network and the posterior default mode network, with distinct patterns of internetwork connectivity observed across different clinical phases. No significant correlations were found between altered brain regions and psychological scales in UC patients. These findings imply that UC patients may undergo functional network alterations, affecting both intranetwork connectivity within RSNs and internetwork connectivity between RSNs.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"702-712"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of glucocorticoid therapy on brain white matter microstructure in thyroid-associated ophthalmopathy: a longitudinal diffusion kurtosis imaging study.","authors":"Qian Wu, Jin-Ling Lu, Jiang Zhou, Xiong-Ying Pu, Huan-Huan Chen, Fei-Yun Wu, Xiao-Quan Xu, Hao Hu","doi":"10.1007/s11682-025-01025-6","DOIUrl":"https://doi.org/10.1007/s11682-025-01025-6","url":null,"abstract":"<p><p>To investigate the changes in brain white matter microstructure in patients with thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid therapy using diffusion kurtosis imaging (DKI) with tract-based spatial statistics (TBSS) method. Twenty TAO patients and 20 healthy controls were enrolled for clinical and magnetic resonance imaging (MRI) examinations. All patients had intravenous glucocorticoid therapy, followed by MRI scans and clinical assessments three months after the treatment ended. TBSS was used to evaluate the mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), kurtosis fractional anisotropy, fractional anisotropy (FA) and mean diffusion of brain white matter. At baseline, TAO patients showed significantly decreased MK, AK, RK and FA in extensive white matter tracts compared to controls. After therapy, increased MK and AK were observed in comparison to the pre-therapy cohort. However, post-therapy TAO patients still exhibited reduced RK in partial white matter tracts compared to controls. RK values in left posterior thalamic radiation (PTR) showed a negative correlation with CAS in pre-therapy TAO patients. Meanwhile, RK values in left PTR were positively correlated with quality of life scores for visual functioning, and RK values in left anterior corona radiata were negatively correlated with anxiety scores in post-therapy TAO patients. Our findings suggested that TAO could lead to white matter deficits in the visual, cognitive, and emotional brain areas, which were partially restored after treatment.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sigrid Breit, Niklaus Denier, Nicolas Mertse, Sebastian Walther, Leila M Soravia, Andrea Federspiel, Roland Wiest, Tobias Bracht
{"title":"The neurobiology of motivational anhedonia in patients with depression.","authors":"Sigrid Breit, Niklaus Denier, Nicolas Mertse, Sebastian Walther, Leila M Soravia, Andrea Federspiel, Roland Wiest, Tobias Bracht","doi":"10.1007/s11682-025-00999-7","DOIUrl":"10.1007/s11682-025-00999-7","url":null,"abstract":"<p><p>Anhedonia is a core feature of depression. It contains a consummatory and a motivational aspect. Whilst much neuroimaging research in patients with depression focused on the consummatory aspect of anhedonia, less is known about its motivational aspect. This study aimed to explore the neurobiology of networks related to motivational anhedonia. Thirty-eight patients with major depressive disorder (MDD) and 19 healthy controls underwent diffusion-weighted and resting state functional magnetic resonance imaging (rs-fMRI). For assessment of motivational anhedonia, we summed the values of the CORE non-interactiveness score, and the items 1 (hopelessness) and 7 (work and activities) of the Hamilton Depression Rating Scale. Whole-brain voxel-wise statistical analysis of fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics (TBSS). Additionally, we performed a whole-brain comparison of integrated local correlation of rs-fMRI signal (LCOR), to investigate regional functional differences between patients and healthy controls. Whole brain correlations between motivational anhedonia and measures of structural and functional connectivity (FA, and LCOR) were calculated. TBSS-analyses revealed reduced FA in the left superior longitudinal fasciculus (SLF) in patients with MDD. LCOR was reduced in patients with depression in an adjacent cluster localized in bilateral precunei. Within patients, there was a positive correlation between motivational anhedonia and LCOR in the precunei and a negative correlation in bilateral sensorimotor areas. FA-values did not show significant correlations. These findings suggest that motivational anhedonia in depression is linked to alterations of functional connectivity within bilateral precunei. Observed white matter microstructural alterations in the SLF do not show such an association.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"690-701"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stacy N Hudgins, Adrian Curtin, Joseph Tracy, Hasan Ayaz
{"title":"Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.","authors":"Stacy N Hudgins, Adrian Curtin, Joseph Tracy, Hasan Ayaz","doi":"10.1007/s11682-025-01006-9","DOIUrl":"10.1007/s11682-025-01006-9","url":null,"abstract":"<p><p>Cognitive dysmetria suggests a disorganization of cognitive processes, particularly in relation to the cerebellum's role in coordinating thoughts and actions. This phenomenon has been extensively studied in various psychiatric disorders, including schizophrenia (SCHZ), bipolar disorder II (BIPOL), and attention-deficit/hyperactivity disorder (ADHD). Understanding the relationship between cognitive dysmetria and functional connectivity in these disorders would reveal significant insights into their neurobiological underpinnings. This study explores how distinct and similar functional network connectivity (FNC) patterns between brain regions are associated with clinical symptoms and trait assessments across SCHZ, BIPOL, and ADHD patients by examining both working memory and task-free conditions compared to healthy volunteers (HC). Leveraging an open-source fMRI dataset from the UCLA Consortium for Neuropsychiatric Phenomics, we analyzed FNC patterns across 115 default mode and salience network regions, including cortical, subcortical, and cerebellar regions of interest in 135 participants (39 HC, 27 SCHZ patients, 38 BIPOL patients, and 31 ADHD patients). Abnormal FNC patterns compared to HC were localized to the cerebellar, thalamic, striatal, hippocampal, medial prefrontal and anterior insular cortices. Post-hoc multiple comparison analysis showed abnormal network connectivity predominantly in SCHZ and ADHD patients during rest, while the task condition demonstrated differential effects across all three disorders. Statistical analysis using a factor-by-covariance approach (GLM MANCOVA) suggested that regional functional connectivity was associated with select symptoms and traits pointing to neural signatures underlying psychiatric conditions. Our study suggests that examining and harnessing dysfunctional relationships in subcortical and cerebellar regions could provide a new perspective on the neurobiological basis of psychoses and help improve available treatment strategies.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"759-770"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}