Brain Imaging and Behavior最新文献_第10页

Structural and functional changes following brain surgery in pediatric patients with intracranial space-occupying lesions. 颅内占位性病变儿科患者脑部手术后的结构和功能变化。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-08-01 Epub Date: 2024-02-20 DOI: 10.1007/s11682-023-00799-x

Xueyi Guan, Wenjian Zheng, Kaiyu Fan, Xu Han, Bohan Hu, Xiang Li, Zihan Yan, Zheng Lu, Jian Gong

{"title":"Structural and functional changes following brain surgery in pediatric patients with intracranial space-occupying lesions.","authors":"Xueyi Guan, Wenjian Zheng, Kaiyu Fan, Xu Han, Bohan Hu, Xiang Li, Zihan Yan, Zheng Lu, Jian Gong","doi":"10.1007/s11682-023-00799-x","DOIUrl":"10.1007/s11682-023-00799-x","url":null,"abstract":"We explored the structural and functional changes of the healthy hemisphere of the brain after surgery in children with intracranial space-occupying lesions. We enrolled 32 patients with unilateral intracranial space-occupying lesions for brain imaging and cognitive assessment. Voxel-based morphometry and surface-based morphometry analyses were used to investigate the structural images of the healthy hemisphere. Functional images were analyzed using regional homogeneity, amplitude of low-frequency fluctuations, and fractional-amplitude of low-frequency fluctuations. Voxel-based morphometry and surface-based morphometry analysis used the statistical model built into the CAT 12 toolbox. Paired t-tests were used for functional image and cognitive test scores. For structural image analysis, we used family-wise error correction of peak level (p < 0.05), and for functional image analysis, we use Gaussian random-field theory correction (voxel p < 0.001, cluster p < 0.05). We found an increase in gray matter volume in the healthy hemisphere within six months postoperatively, mainly in the frontal lobe. Regional homogeneity and fractional-amplitude of low-frequency fluctuations also showed greater functional activity in the frontal lobe. The results of cognitive tests showed that psychomotor speed and motor speed decreased significantly after surgery, and reasoning increased significantly after surgery. We concluded that in children with intracranial space-occupying lesions, the healthy hemisphere exhibits compensatory structural and functional effects within six months after surgery. This effect occurs mainly in the frontal lobe and is responsible for some higher cognitive compensation. This may provide some guidance for the rehabilitation of children after brain surgery.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"710-719"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of effects of eight-week left dorsolateral prefrontal theta burst stimulation on white matter macro/microstructure and connection in autism. 为期八周的左侧背外侧前额叶θ脉冲刺激对自闭症患者的白质宏观/微观结构和连接缺乏影响。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-08-01 Epub Date: 2024-03-16 DOI: 10.1007/s11682-024-00874-x

Chun-Hung Yeh, Po-Chun Lin, Rung-Yu Tseng, Yi-Ping Chao, Chen-Te Wu, Tai-Li Chou, Rou-Shayn Chen, Susan Shur-Fen Gau, Hsing-Chang Ni, Hsiang-Yuan Lin

{"title":"Lack of effects of eight-week left dorsolateral prefrontal theta burst stimulation on white matter macro/microstructure and connection in autism.","authors":"Chun-Hung Yeh, Po-Chun Lin, Rung-Yu Tseng, Yi-Ping Chao, Chen-Te Wu, Tai-Li Chou, Rou-Shayn Chen, Susan Shur-Fen Gau, Hsing-Chang Ni, Hsiang-Yuan Lin","doi":"10.1007/s11682-024-00874-x","DOIUrl":"10.1007/s11682-024-00874-x","url":null,"abstract":"Whether brain stimulation could modulate brain structure in autism remains unknown. This study explored the impact of continuous theta burst stimulation (cTBS) over the left dorsolateral prefrontal cortex (DLPFC) on white matter macro/microstructure in intellectually able children and emerging adults with autism. Sixty autistic participants were randomized (30 active) and received active or sham cTBS for eight weeks twice per week, 16 total sessions using a double-blind (participant-, rater-, analyst-blinded) design. All participants received high-angular resolution diffusion MR imaging at baseline and week 8. Twenty-eight participants in the active group and twenty-seven in the sham group with good imaging quality entered the final analysis. With longitudinal fixel-based analysis and network-based statistics, we found no significant difference between the active and sham groups in changes of white matter macro/microstructure and connections following cTBS. In addition, we found no association between baseline white matter macro/microstructure and autistic symptom changes from baseline to week 8 in the active group. In conclusion, we did not find a significant impact of left DLPFC cTBS on white matter macro/microstructure and connections in children and emerging adults with autism. These findings need to be interpreted in the context that the current intellectually able cohort in a single university hospital site limits the generalizability. Future studies are required to investigate if higher stimulation intensities and/or doses, other personal factors, or rTMS parameters might confer significant brain structural changes visible on MRI in ASD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"794-807"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140139940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Upper Airway Anatomy with Brain Structure: The Multi-Ethnic Study of Atherosclerosis. 上气道解剖与大脑结构的关系：多种族动脉粥样硬化研究

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-01-09 DOI: 10.1007/s11682-023-00843-w

Robin M Nance, Alison E Fohner, Robyn L McClelland, Susan Redline, R Nick Bryan, Lisa Desiderio, Mohamad Habes, W T Longstreth, Richard J Schwab, Andrew S Wiemken, Susan R Heckbert

{"title":"The Association of Upper Airway Anatomy with Brain Structure: The Multi-Ethnic Study of Atherosclerosis.","authors":"Robin M Nance, Alison E Fohner, Robyn L McClelland, Susan Redline, R Nick Bryan, Lisa Desiderio, Mohamad Habes, W T Longstreth, Richard J Schwab, Andrew S Wiemken, Susan R Heckbert","doi":"10.1007/s11682-023-00843-w","DOIUrl":"10.1007/s11682-023-00843-w","url":null,"abstract":"Sleep apnea, affecting an estimated 1 in 4 American adults, has been reported to be associated with both brain structural abnormality and impaired cognitive function. Obstructive sleep apnea is known to be affected by upper airway anatomy. To better understand the contribution of upper airway anatomy to pathways linking sleep apnea with impaired cognitive function, we investigated the association of upper airway anatomy with structural brain abnormalities. Based in the Multi-Ethnic Study of Atherosclerosis, a longitudinal cohort study of community-dwelling adults, a comprehensive sleep study and an MRI of the upper airway and brain were performed on 578 participants. Machine learning models were used to select from 74 upper airway measures those measures most associated with selected regional brain volumes and white matter hyperintensity volume. Linear regression assessed associations between the selected upper airway measures, sleep measures, and brain structure. Maxillary divergence was positively associated with hippocampus volume, and mandible length was negatively associated with total white and gray matter volume. Both coefficients were small (coefficients per standard deviation 0.063 mL, p = 0.04, and - 7.0 mL, p < 0.001 respectively), and not affected by adjustment for sleep study measures. Self-reported snoring >2 times per week was associated with larger hippocampus volume (coefficient 0.164 mL, p = 0.007), and higher percentage of time in the N3 sleep stage was associated with larger total white and gray matter volume (4.8 mL, p = 0.004). Despite associations of two upper airway anatomy measures with brain volume, the evidence did not suggest that these upper airway and brain structure associations were acting primarily through the pathway of sleep disturbance.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"510-518"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How the intrinsic functional connectivity patterns of the semantic network support semantic processing. 语义网络的内在功能连接模式如何支持语义处理。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-01-23 DOI: 10.1007/s11682-024-00849-y

Chengmei Huang, Aqian Li, Yingdan Pang, Jiayi Yang, Jingxian Zhang, Xiaoyan Wu, Leilei Mei

{"title":"How the intrinsic functional connectivity patterns of the semantic network support semantic processing.","authors":"Chengmei Huang, Aqian Li, Yingdan Pang, Jiayi Yang, Jingxian Zhang, Xiaoyan Wu, Leilei Mei","doi":"10.1007/s11682-024-00849-y","DOIUrl":"10.1007/s11682-024-00849-y","url":null,"abstract":"Semantic processing, a core of language comprehension, involves the activation of brain regions dispersed extensively across the frontal, temporal, and parietal cortices that compose the semantic network. To comprehend the functional structure of this semantic network and how it prepares for semantic processing, we investigated its intrinsic functional connectivity (FC) and the relation between this pattern and semantic processing ability in a large sample from the Human Connectome Project (HCP) dataset. We first defined a well-studied brain network for semantic processing, and then we characterized the within-network connectivity (WNC) and the between-network connectivity (BNC) within this network using a voxel-based global brain connectivity (GBC) method based on resting-state functional magnetic resonance imaging (fMRI). The results showed that 97.73% of the voxels in the semantic network displayed considerably greater WNC than BNC, demonstrating that the semantic network is a fairly encapsulated network. Moreover, multiple connector hubs in the semantic network were identified after applying the criterion of WNC > 1 SD above the mean WNC of the semantic network. More importantly, three of these connector hubs (i.e., the left anterior temporal lobe, angular gyrus, and orbital part of the inferior frontal gyrus) were reliably associated with semantic processing ability. Our findings suggest that the three identified regions use WNC as the central mechanism for supporting semantic processing and that task-independent spontaneous connectivity in the semantic network is essential for semantic processing.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"539-554"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attentional impairment and altered brain activity in healthcare workers after mild COVID-19. 轻度 COVID-19 后医护人员的注意力受损和大脑活动改变。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-01 DOI: 10.1007/s11682-024-00851-4

Keyi Lin, Yaotian Gao, Wei Ji, Yan Li, Wei Wang, Mengcheng Du, Jia Liu, Zhengyu Hong, Tao Jiang, Yuyang Wang

{"title":"Attentional impairment and altered brain activity in healthcare workers after mild COVID-19.","authors":"Keyi Lin, Yaotian Gao, Wei Ji, Yan Li, Wei Wang, Mengcheng Du, Jia Liu, Zhengyu Hong, Tao Jiang, Yuyang Wang","doi":"10.1007/s11682-024-00851-4","DOIUrl":"10.1007/s11682-024-00851-4","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is highly transmissible and pathogenic. Patients with mild cases account for the majority of those infected with coronavirus disease 2019 (COVID-19). Although there is evidence that many patients with COVID-19 have varying degrees of attentional impairment, little is known about how SARS-COV-2 affects attentional function. This study included a high-risk healthcare population divided into groups of healthcare workers (HCWs) with mild COVID-19 (patient group, n = 45) and matched healthy HCWs controls (HC group, n = 42), who completed general neuropsychological background tests and Attention Network Test (ANT), and underwent resting-state functional magnetic resonance imaging (rs-fMRI) using amplitude of low-frequency fluctuation (ALFF) to assess altered brain activity; Selective impairment occurred in orienting and executive control networks, but not in alert network, in the patient group, and widespread cognitive impairment encompassing general attention, memory, and executive dysfunction. Moreover, the patient group had significantly lower ALFF values in the left superior and left middle frontal gyri than the HC group. SARS-COV-2 infection may have led to reduced brain activity in the left superior and left middle frontal gyri, thus impairing attentional orienting and executive control networks, which may explain the development of attentional deficits after COVID-19.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"566-575"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia. 首发精神分裂症患者前扣带回皮层亚区不同的静息态功能连接。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-13 DOI: 10.1007/s11682-024-00863-0

Huan Huang, Cheng Chen, Bei Rong, Yuan Zhou, Wei Yuan, Yunlong Peng, Zhongchun Liu, Gaohua Wang, Huiling Wang

{"title":"Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia.","authors":"Huan Huang, Cheng Chen, Bei Rong, Yuan Zhou, Wei Yuan, Yunlong Peng, Zhongchun Liu, Gaohua Wang, Huiling Wang","doi":"10.1007/s11682-024-00863-0","DOIUrl":"10.1007/s11682-024-00863-0","url":null,"abstract":"The anterior cingulate cortex (ACC) is a heterogeneous region of the brain's limbic system that regulates cognitive and emotional processing, and is frequently implicated in schizophrenia. This study aims to characterize resting-state functional connectivity (rsFC) profiles of three subregions of ACC in patients with first-episode schizophrenia and healthy controls. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were collected from 60 first-episode schizophrenia (FES) patients and 60 healthy controls (HC), and the subgenual ACC (sgACC), pregenual ACC (pgACC), and dorsal ACC (dACC) were selected as seed regions from the newest automated anatomical labeling atlas 3 (AAL3). Seed-based rsFC maps for each ACC subregion were generated and compared between the two groups. The results revealed that compared to the HC group, the FES group showed higher rsFC between the pgACC and bilateral lateral orbitofrontal cortex (lOFC), and lower rsFC between the dACC and right posterior OFC (pOFC), the medial prefrontal gyrus (MPFC), and the precuneus cortex (PCu). These findings point to a selective functional dysconnectivity of pgACC and dACC in schizophrenia and provide more accurate information about the functional role of the ACC in this disorder.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"675-685"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered spontaneous regional brain activity in ventromedial prefrontal cortex and visual area of expert table tennis athletes. 乒乓球高手腹外侧前额叶皮层和视觉区的自发区域脑活动改变

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-01-22 DOI: 10.1007/s11682-023-00841-y

Yapeng Qi, Mengqi Zhao, Zhurui Yan, Xize Jia, Yingying Wang

{"title":"Altered spontaneous regional brain activity in ventromedial prefrontal cortex and visual area of expert table tennis athletes.","authors":"Yapeng Qi, Mengqi Zhao, Zhurui Yan, Xize Jia, Yingying Wang","doi":"10.1007/s11682-023-00841-y","DOIUrl":"10.1007/s11682-023-00841-y","url":null,"abstract":"Sports training may lead to functional changes in the brain, and different types of sports, including table tennis, have different influences on these changes. However, the effects of long-term table tennis practice on brain function in expert athletes are largely undefined. Here, we investigated spontaneous regional brain activity characteristics of expert table tennis athletes by using resting-state functional magnetic resonance imaging to compare differences between 25 athletes and 33 age- and sex-matched non-athletes. We analyzed four metrics-amplitude of low-frequency fluctuation (ALFF), fractional ALFF, regional homogeneity, and degree centrality-because together they identify functional changes in the brain with greater sensitivity than a single indicator and may more comprehensively describe regional functional changes. Additional statistical analysis was conducted to assess whether any correlation existed between brain activity and years of table tennis training for athletes. Results show that compared with non-athletes, table tennis athletes showed altered spontaneous regional brain activity in the ventromedial prefrontal cortex and the calcarine sulcus, a visual area. Furthermore, the functional changes in the calcarine sulcus showed a significant correlation with the number of years of expert sports training. Despite the relatively small sample size, these results indicated that the regional brain function of table tennis athletes was associated with sports training-related changes, providing insights for understanding the neural mechanisms underlying the expert performance of athletes.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"529-538"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous brain activity associated with individual differences in decisional and emotional forgiveness. 自发的大脑活动与决策和情感宽恕的个体差异有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-07 DOI: 10.1007/s11682-024-00856-z

Haijiang Li, Wenyuan Wang, Jingyu Li, Jiang Qiu, Yuedong Wu

{"title":"Spontaneous brain activity associated with individual differences in decisional and emotional forgiveness.","authors":"Haijiang Li, Wenyuan Wang, Jingyu Li, Jiang Qiu, Yuedong Wu","doi":"10.1007/s11682-024-00856-z","DOIUrl":"10.1007/s11682-024-00856-z","url":null,"abstract":"Previous studies have explored the neural bases of forgiveness, however, the neural associations of decisional and emotional forgiveness remain unclear. Regional homogeneity (ReHo) and functional connectivity (FC) measured by resting-state functional magnetic resonance imaging (fMRI) were used to investigate the neural associations of individual differences in decisional and emotional forgiveness among healthy volunteers (256 participants, 85 males). The results of the ReHo analysis showed that decisional forgiveness was positively correlated with the left inferior parietal lobule (IPL). Furthermore, emotional forgiveness was positively correlated with the dorsal anterior cingulate cortex (dACC) and left supramarginal gyrus (SMG). The results of the FC analysis showed that decisional forgiveness was positively associated with the FC strength between the left IPL and left middle frontal gyrus (MFG) and negatively correlated with the FC strength among the left IPL, right superior temporal gyrus (STG), and left SMG. Furthermore, there was a significant positive correlation between emotional forgiveness and FC strength between the left SMG and right IPL. These findings suggest an association between decisional and emotional forgiveness and spontaneous brain activity in brain regions related to empathy, emotion regulation, and cognitive control.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"588-597"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease. 大脑网络中心性和连通性与帕金森病的临床亚型和疾病进展有关。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-10 DOI: 10.1007/s11682-024-00862-1

Zhenzhen Chen, Chentao He, Piao Zhang, Xin Cai, Xiaohong Li, Wenlin Huang, Sifei Huang, Mengfei Cai, Lijuan Wang, Peiyan Zhan, Yuhu Zhang

{"title":"Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease.","authors":"Zhenzhen Chen, Chentao He, Piao Zhang, Xin Cai, Xiaohong Li, Wenlin Huang, Sifei Huang, Mengfei Cai, Lijuan Wang, Peiyan Zhan, Yuhu Zhang","doi":"10.1007/s11682-024-00862-1","DOIUrl":"10.1007/s11682-024-00862-1","url":null,"abstract":"To investigate brain network centrality and connectivity alterations in different Parkinson's disease (PD) clinical subtypes using resting-state functional magnetic resonance imaging (RS-fMRI), and to explore the correlation between baseline connectivity changes and the clinical progression. Ninety-two PD patients were enrolled at baseline, alongside 38 age- and sex-matched healthy controls. Of these, 85 PD patients underwent longitudinal assessments with a mean of 2.75 ± 0.59 years. Two-step cluster analysis integrating comprehensive motor and non-motor manifestations was performed to define PD subtypes. Degree centrality (DC) and secondary seed-based functional connectivity (FC) were applied to identify brain network centrality and connectivity changes among groups. Regression analysis was used to explore the correlation between baseline connectivity changes and clinical progression. Cluster analysis identified two main PD subtypes: mild PD and moderate PD. Two different subtypes within the mild PD were further identified: mild motor-predominant PD and mild-diffuse PD. Accordingly, the disrupted DC and seed-based FC in the left inferior frontal orbital gyrus and left superior occipital gyrus were severe in moderate PD. The DC and seed-based FC alterations in the right gyrus rectus and right postcentral gyrus were more severe in mild-diffuse PD than in mild motor-predominant PD. Moreover, disrupted DC were associated with clinical manifestations at baseline in patients with PD and predicted motor aspects progression over time. Our study suggested that brain network centrality and connectivity changes were different among PD subtypes. RS-fMRI holds promise to provide an objective assessment of subtype-related connectivity changes and predict disease progression in PD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"646-661"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increasing variance of rich-club nodes distribution in early onset depression according to dynamic network. 根据动态网络，早期抑郁症患者富俱乐部节点分布的方差不断增大。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-06-01 Epub Date: 2024-02-13 DOI: 10.1007/s11682-023-00848-5

Naikeng Mai, Yujie Wu, Xiaomei Zhong, Ben Chen, Min Zhang, Qi Peng, Yuping Ning

{"title":"Increasing variance of rich-club nodes distribution in early onset depression according to dynamic network.","authors":"Naikeng Mai, Yujie Wu, Xiaomei Zhong, Ben Chen, Min Zhang, Qi Peng, Yuping Ning","doi":"10.1007/s11682-023-00848-5","DOIUrl":"10.1007/s11682-023-00848-5","url":null,"abstract":"Early onset depression (EOD) and late onset depression (LOD) are thought to have different pathogeneses, but lack of pathological evidence. In the current study we describe the dynamic rich-club properties of patients with EOD and LOD to address this question indirectly. We recruited 82 patients with late life depression (EOD 40, LOD 42) and 90 healthy controls. Memory, executive function and processing speed were measured, and resting-stage functional MRI was performed with all participants. We constructed a dynamic functional connectivity network and carried out rich-club and modularity analyses. Normalized mutual information (NMI) was applied to describe the variance in rich-club nodes distribution and partitioning. The NMI coefficient of rich club nodes distribution among the three groups was the lowest in the EOD patients (F = 4.298; P = 0.0151, FDR = 0.0231), which was positively correlated with rich-club connectivity (R = 0.886, P < 0.001) and negatively correlated with memory (R = -0.347, P = 0.038) in the EOD group. In the LOD patients, non-rich-club connectivity was positively correlated with memory (R = 0.353, P = 0.030 and R = 0.420, P = 0.009). Furthermore, local connectivity was positively correlated with processing speed in the LOD patients (R = 0.374, P = 0.021). The modular partition was different between the EOD patients and the HCs (P = 0.0013 < 0.05/3). The temporal instability of rich-club nodes was found in the EOD patients, but not the LOD patients, supporting the hypothesis that EOD and LOD result from different pathogenesis, and showing that the instability of the rich-club nodes across time might disrupt rich-club connectivity.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"662-674"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0