Brain Imaging and Behavior最新文献_第4页

Static and temporal dynamic alterations of local functional connectivity in chronic insomnia 慢性失眠症患者局部功能连接的静态和时态动态变化

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-18 DOI: 10.1007/s11682-024-00928-0

Jingwen Li, Shumei Li, Shaoqin Zeng, Xinzhi Wang, Mengchen Liu, Guang Xu, Xiaofen Ma

{"title":"Static and temporal dynamic alterations of local functional connectivity in chronic insomnia","authors":"Jingwen Li, Shumei Li, Shaoqin Zeng, Xinzhi Wang, Mengchen Liu, Guang Xu, Xiaofen Ma","doi":"10.1007/s11682-024-00928-0","DOIUrl":"https://doi.org/10.1007/s11682-024-00928-0","url":null,"abstract":"Several studies have revealed altered intrinsic neural activity in chronic insomnia (CI). However, the temporal variability of intrinsic neural activity in CI is rarely mentioned. This study aimed to explore static and temporal dynamic alterations of regional homogeneity (ReHo) in CI and excavate the potential associations between these changes and clinical characteristics. Eighty-seven patients with CI and seventy-eight healthy controls (HCs) were included. Resting-state functional magnetic resonance imaging was performed on all subjects and both static and dynamic ReHo were used to detect local functional connectivity. We then tested the relationship between altered brain regions, disease duration, and clinical scales. The receiver operating characteristic curve analysis was used to reveal the potential capability of these indicators to screen CI patients from HCs. CI showed increased dynamic ReHo in the right precuneus and decreased static ReHo in the right cerebellum_6. The dynamic ReHo values of the right precuneus were negatively correlated with the self-rating depression score and the static ReHo values of the right cerebellum_6 were positively correlated with the Montreal Cognitive Assessment-Naming score. In addition, the combination of the two metrics showed a potential capacity to distinguish CI patients from HCs, which was better than a single metric alone. The present study has revealed the altered local functional connectivity under static and temporal dynamic conditions in patients with CI, and found the relationships between these changes, mood-related scales, and cognitive-related scales. These may be useful in elucidating the neurological mechanisms of CI and accompanying symptoms.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telehealth-delivered cognitive behavioral therapy - a potential solution to improve sleep quality and normalize the salience network in fibromyalgia: a pilot randomized trial 远程医疗认知行为疗法--改善纤维肌痛患者睡眠质量并使突出网络正常化的潜在解决方案：一项试点随机试验

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-17 DOI: 10.1007/s11682-024-00925-3

Nguyen Thanh Nhu, Cheng-Ze Wong, Ivy Y. Chen, Ya-Wen Jan, Jiunn-Horng Kang

{"title":"Telehealth-delivered cognitive behavioral therapy - a potential solution to improve sleep quality and normalize the salience network in fibromyalgia: a pilot randomized trial","authors":"Nguyen Thanh Nhu, Cheng-Ze Wong, Ivy Y. Chen, Ya-Wen Jan, Jiunn-Horng Kang","doi":"10.1007/s11682-024-00925-3","DOIUrl":"https://doi.org/10.1007/s11682-024-00925-3","url":null,"abstract":"Our study investigated the associations between the clinical benefits of telehealth-delivered cognitive behavioral therapy for insomnia (tele-CBT-I) and the salience network in fibromyalgia (FM). Thirty-five FM patients with comorbid insomnia were recruited and assigned into two groups: the tele-CBT-I group (n = 17) or the treatment-as-usual (TAU) group (n = 18). At baseline and post-treatment, clinical status was assessed using standardized scales, including the Insomnia Severity Index (ISI), Brief Pain Inventory, Numeric Pain Rating scale, Beck Depression Intervention version II, Beck Anxiety Intervention, Situational Fatigue Scale, and Fibromyalgia Impact Questionnaires. Resting-state functional magnetic resonance imaging was collected. We compared within- and between-group differences in clinical changes and functional connectivity (FC) of the salience network. A factor analysis of significant FCs was performed. Correlation analyses between clinical symptoms and salience FCs were conducted. The tele-CBT-I group showed sleep quality improvements after treatment that were greater than those in the TAU group (p-value = 0.038). After treatment, tele-CBT-I decreased FCs of cortical regions and increased FCs of subcortical regions compared to the TAU group. Additionally, factor analysis grouped the significant FCs into cortical factors and subcortical factors. The cortical factor value, representing the involvement of specific cortical regions of the salience network by the factor analysis, was significantly associated with ISI scores in the tele-CBT-I group (p-value = 0.0002). In conclusion, tele-CBT-I might be an adjuvant approach to improve sleep quality and normalize cortical and subcortical functions of the salience network in FM patients with comorbid insomnia.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupted brain functional asymmetry at rest in patients with major depressive disorder associated with sleep disturbances 与睡眠障碍有关的重度抑郁症患者在休息时大脑功能不对称的紊乱现象

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-14 DOI: 10.1007/s11682-024-00924-4

Dan Lv, Yangpan Ou, Huabing Li, Feng Liu, Ping Li, Dongsheng Lv, Jingping Zhao, Wenbin Guo

{"title":"Disrupted brain functional asymmetry at rest in patients with major depressive disorder associated with sleep disturbances","authors":"Dan Lv, Yangpan Ou, Huabing Li, Feng Liu, Ping Li, Dongsheng Lv, Jingping Zhao, Wenbin Guo","doi":"10.1007/s11682-024-00924-4","DOIUrl":"https://doi.org/10.1007/s11682-024-00924-4","url":null,"abstract":"Sleep disturbances (SD) are common in major depressive disorder (MDD) patients. Brain functional asymmetry is crucial for understanding MDD pathophysiology. Previous studies using the parameter of asymmetry (PAS) approach have found brain functional asymmetry disruption in MDD. However, this has not been explored in MDD patients with SD. This study examined 26 MDD patients with SD, 34 MDD patients without SD, and 34 healthy controls using resting-state functional magnetic resonance imaging scans. SD symptoms were quantified using the 17-item Hamilton Rating Scale for Depression. PAS approach was used to evaluate functional asymmetry. MDD patients with SD displayed increased PAS in the left middle frontal gyrus (MFG)/inferior frontal gyrus (IFG) and decreased PAS in the left parahippocampal gyrus (PHG) compared to MDD patients without SD. Increased PAS in the left MFG/IFG was positively correlated with SD severity, and a negative correlation was found between decreased PAS in the left PHG and SD scores in all MDD patients. Receiver operating characteristic analysis indicated that increased PAS in the left MFG/IFG and decreased PAS in the left PHG may serve as potential neuroimaging markers to differentiate MDD patients with SD from those without SD with Area Under Curve values of 0.8157 and 0.8068, respectively. These results highlighted that increased PAS in the left MFG/IFG and decreased PAS in the left PHG may be considered a prominent feature associated with SD symptoms of MDD patients, potentially serving as imaging markers to discriminate between MDD patients with and without SD.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insomnia and stress: the mediating roles of frontoparietal network 失眠与压力：前顶叶网络的中介作用

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-13 DOI: 10.1007/s11682-024-00922-6

Miao He, Yuan Li, Mengting Chen, Huiyun Li, Chunrong Liang, Yanli Chen, Chunyan Long, Yuting Yang, Jingyi Ye, Yu Mao, Yan Wang, Ling Li

{"title":"Insomnia and stress: the mediating roles of frontoparietal network","authors":"Miao He, Yuan Li, Mengting Chen, Huiyun Li, Chunrong Liang, Yanli Chen, Chunyan Long, Yuting Yang, Jingyi Ye, Yu Mao, Yan Wang, Ling Li","doi":"10.1007/s11682-024-00922-6","DOIUrl":"https://doi.org/10.1007/s11682-024-00922-6","url":null,"abstract":"Insomnia is a widespread health problem among adults, and it impairs cognitive control and emotional regulation functions. Stress and insomnia are positively correlated, and their vicious cycle has been widely reported. In this study, we explore the neural biomarkers of insomnia from the perspective of whole-brain functional connectivity and investigate the neural mechanisms underlying the association between stress and insomnia. The current study was conducted on a cross-sectional sample (N = 430). First, we investigated the correlation between perceived stress and insomnia. Second, we applied connectome-based predictive modeling (CPM) to determine the neuromarkers of insomnia. Finally, we explored the neural basis underlying the association between perceived stress and insomnia. A significant positive correlation was found between perceived stress and insomnia in the present research. Results of CPM revealed the following as the neural substrates supporting insomnia: the emotion regulation circuit involving repetitive negative thinking and the cognitive control circuit involving attention control. According to further results from mediation analysis, the frontoparietal network supporting cognitive emotion regulation is an important neural mechanism that maintains the correlation between stress and insomnia. The present study offers a profound insight into the alterations of brain activity related to insomnia, and it further investigates the neural underpinnings of the robust association between stress and insomnia. This study also opens new avenues for neural interventions to alleviate stress-related insomnia.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults 功能连接性降低与老年人脑脊液可溶性表皮生长因子受体β（血脑屏障破坏的标志物）水平升高有关

IF 3.2 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-10 DOI: 10.1007/s11682-024-00912-8

Joey A. Contreras, Kimiko Fujisaki, Nancy E. Ortega, Giuseppe Barisano, Abhay Sagare, Ioannis Pappas, Helena Chui, John M. Ringman, Elizabeth B. Joe, Berislav V. Zlokovic, Arthur W. Toga, Judy Pa

{"title":"Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults","authors":"Joey A. Contreras, Kimiko Fujisaki, Nancy E. Ortega, Giuseppe Barisano, Abhay Sagare, Ioannis Pappas, Helena Chui, John M. Ringman, Elizabeth B. Joe, Berislav V. Zlokovic, Arthur W. Toga, Judy Pa","doi":"10.1007/s11682-024-00912-8","DOIUrl":"https://doi.org/10.1007/s11682-024-00912-8","url":null,"abstract":"Resting-state functional connectivity (FC) is suggested to be cross-sectionally associated with both vascular burden and Alzheimer's disease (AD) pathology. For instance, studies in pre-clinical AD subjects have shown increases of cerebral spinal fluid soluble platelet-derived growth factor receptor-β (CSF sPDGFRβ, a marker of BBB breakdown) but have not demonstrated if this vascular impairment affects neuronal dysfunction. It’s possible that increased levels of sPDGFRβ in the CSF may correlate with impaired FC in metabolically demanding brain regions (i.e. Default Mode Network, DMN). Our study aimed to investigate the relationship between these two markers in older individuals that were cognitively normal and had cognitive impairment. Eighty-nine older adults without dementia from the University of Southern California were selected from a larger cohort. Region of interest (ROI) to ROI analyses were conducted using DMN seed regions. Linear regression models measured significant associations between BOLD FC strength among seed-target regions and sPDGFRβ values, while covarying for age and sex. Comparison of a composite ROI created by averaging FC values between seed and all target regions among cognitively normal and impaired individuals was also examined. Using CSF sPDGFRβ as a biomarker of BBB breakdown, we report that increased breakdown correlated with decreased functional connectivity in DMN areas, specifically the PCC, and while the hippocampus exhibited an interaction effect using CDR score, this was an exploratory analysis that we feel can lead to further research. Ultimately, we found that BBB breakdown, as measured by CSF sPDGFRβ, is associated with neural networks, and decreased functional connections.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical activity and hippocampal volume in young adults. 体育锻炼与年轻人的海马体积

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-09 DOI: 10.1007/s11682-024-00916-4

Anastasia Cherednichenko, Anna Miró-Padilla, Jesús Adrián-Ventura, Irene Monzonís-Carda, Maria Reyes Beltran-Valls, Diego Moliner-Urdiales, César Ávila

{"title":"Physical activity and hippocampal volume in young adults.","authors":"Anastasia Cherednichenko, Anna Miró-Padilla, Jesús Adrián-Ventura, Irene Monzonís-Carda, Maria Reyes Beltran-Valls, Diego Moliner-Urdiales, César Ávila","doi":"10.1007/s11682-024-00916-4","DOIUrl":"https://doi.org/10.1007/s11682-024-00916-4","url":null,"abstract":"Evidence from previous studies suggests that physical activity (PA) may contribute to functional and structural changes in the hippocampus throughout the lifespan. However, there is limited evidence available regarding the young adult population. Additionally, the personality traits that may influence this association remain unclear. With a sample of 84 young adults (43 women; age 22.7 ± 2.8y; range 18-29), the main aim of the current study was to analyze the association between objective and self-reported measures of daily PA and hippocampus subfield gray matter volumes, and to examine the role of the personality trait of punishment sensitivity in this association. Our results showed that only moderate to vigorous levels of objectively measured PA were positively associated with the hippocampal CA2/CA3 volume. Moreover, punishment sensitivity correlated negatively with the objective measure of sedentarism and with self-reported measures of PA. However, regression analyses did not find any interaction between punishment sensitivity and PA in explaining individual differences in hippocampal volumes. Thus, our data suggest that intense PA may contribute to enhancing the hippocampal CA2/CA3 volume in young adults.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting-state functional abnormalities in ischemic stroke: a meta-analysis of fMRI studies. 缺血性脑卒中静息态功能异常：fMRI 研究荟萃分析。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-09 DOI: 10.1007/s11682-024-00919-1

Zheng Zhang

{"title":"Resting-state functional abnormalities in ischemic stroke: a meta-analysis of fMRI studies.","authors":"Zheng Zhang","doi":"10.1007/s11682-024-00919-1","DOIUrl":"https://doi.org/10.1007/s11682-024-00919-1","url":null,"abstract":"Ischemic stroke is a leading neurological cause of severe disabilities and death in the world and has a major negative impact on patients' quality of life. However, the neural mechanism of spontaneous fluctuating neuronal activity remains unclear. This meta-analysis explored brain activity during resting state in patients with ischemic stroke including 22 studies of regional homogeneity, amplitude of low-frequency fluctuation, and fractional amplitude of low-frequency fluctuation (692 patients with ischemic stroke, 620 healthy controls, age range 35-80 years, 41% female, 175 foci). Results showed decreased regional activity in the bilateral caudate and thalamus and increased regional activity in the left superior occipital gyrus and left default mode network (precuneus/posterior cingulate cortex). Meta-analysis of the amplitude of low-frequency fluctuation studies showed that increased activity in the left inferior frontal gyrus was reduced across the progression from acute to chronic phases. These findings may indicate that disruption of the subcortical areas and default mode network could be one of the core functional abnormalities in ischemic stroke. Altered brain activity in the inferior frontal gyrus could be the imaging indicator of brain recovery/plasticity after stroke damage, which offers potential insight into developing prediction models and therapeutic strategies for ischemic stroke rehabilitation and recovery.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia. 额颞叶痴呆症行为症状的多模态非线性相关性。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-07 DOI: 10.1007/s11682-024-00913-7

Giovanna Zamboni, Irene Mattioli, Zobair Arya, Manuela Tondelli, Giulia Vinceti, Annalisa Chiari, Mark Jenkinson, Edward D Huey, Jordan Grafman

{"title":"Multimodal nonlinear correlates of behavioural symptoms in frontotemporal dementia.","authors":"Giovanna Zamboni, Irene Mattioli, Zobair Arya, Manuela Tondelli, Giulia Vinceti, Annalisa Chiari, Mark Jenkinson, Edward D Huey, Jordan Grafman","doi":"10.1007/s11682-024-00913-7","DOIUrl":"10.1007/s11682-024-00913-7","url":null,"abstract":"Studies exploring the brain correlates of behavioral symptoms in the frontotemporal dementia spectrum (FTD) have mainly searched for linear correlations with single modality neuroimaging data, either structural magnetic resonance imaging (MRI) or fluoro-deoxy-D-glucose positron emission tomography (FDG-PET). We aimed at studying the two imaging modalities in combination to identify nonlinear co-occurring patterns of atrophy and hypometabolism related to behavioral symptoms. We analyzed data from 93 FTD patients who underwent T1-weighted MRI, FDG-PET imaging, and neuropsychological assessment including the Neuropsychiatric Inventory, Frontal Systems Behavior Scale, and Neurobehavioral Rating Scale. We used a data-driven approach to identify the principal components underlying behavioral variability, then related the identified components to brain variability using a newly developed method fusing maps of grey matter volume and FDG metabolism. A component representing apathy, executive dysfunction, and emotional withdrawal was associated with atrophy in bilateral anterior insula and putamen, and with hypometabolism in the right prefrontal cortex. Another component representing the disinhibition versus depression/mutism continuum was associated with atrophy in the right striatum and ventromedial prefrontal cortex for disinhibition, and hypometabolism in the left fronto-opercular region and sensorimotor cortices for depression/mutism. A component representing psychosis was associated with hypometabolism in the prefrontal cortex and hypermetabolism in auditory and visual cortices. Behavioral symptoms in FTD are associated with atrophy and altered metabolism of specific brain regions, especially located in the frontal lobes, in a hierarchical way: apathy and disinhibition are mostly associated with grey matter atrophy, whereas psychotic symptoms are mostly associated with hyper-/hypo-metabolism.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can an online battery match in-person cognitive testing in providing information about age-related cortical morphology? 在提供与年龄相关的大脑皮层形态信息方面，在线测试能否与现场认知测试相媲美？

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-07 DOI: 10.1007/s11682-024-00918-2

R Thienel, L Borne, C Faucher, A Behler, G A Robinson, J Fripp, J Giorgio, A Ceslis, K McAloney, J Adsett, D Galligan, N G Martin, M Breakspear, M K Lupton

{"title":"Can an online battery match in-person cognitive testing in providing information about age-related cortical morphology?","authors":"R Thienel, L Borne, C Faucher, A Behler, G A Robinson, J Fripp, J Giorgio, A Ceslis, K McAloney, J Adsett, D Galligan, N G Martin, M Breakspear, M K Lupton","doi":"10.1007/s11682-024-00918-2","DOIUrl":"https://doi.org/10.1007/s11682-024-00918-2","url":null,"abstract":"Clinical identification of early neurodegenerative changes requires an accurate and accessible characterization of brain and cognition in healthy aging. We assessed whether a brief online cognitive assessment can provide insights into brain morphology comparable to a comprehensive neuropsychological battery. In 141 healthy mid-life and older adults, we compared Creyos, a relatively brief online cognitive battery, to a comprehensive in person cognitive assessment. We used a multivariate technique to study the ability of each test to inform brain morphology as indexed by cortical sulcal width extracted from structural magnetic resonance imaging (sMRI).We found that the online test demonstrated comparable strength of association with cortical sulcal width compared to the comprehensive in-person assessment.These findings suggest that in our at-risk sample online assessments are comparable to the in-person assay in their association with brain morphology. With their cost effectiveness, online cognitive testing could lead to more equitable early detection and intervention for neurodegenerative diseases.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional correlation tensors in brain white matter and the effects of normal aging. 大脑白质中的功能相关张量和正常衰老的影响。

IF 2.4 3区医学

Brain Imaging and Behavior Pub Date : 2024-09-05 DOI: 10.1007/s11682-024-00914-6

Lyuan Xu, Yurui Gao, Muwei Li, Richard Lawless, Yu Zhao, Kurt G Schilling, Baxter P Rogers, Adam W Anderson, Zhaohua Ding, Bennett A Landman, John C Gore

{"title":"Functional correlation tensors in brain white matter and the effects of normal aging.","authors":"Lyuan Xu, Yurui Gao, Muwei Li, Richard Lawless, Yu Zhao, Kurt G Schilling, Baxter P Rogers, Adam W Anderson, Zhaohua Ding, Bennett A Landman, John C Gore","doi":"10.1007/s11682-024-00914-6","DOIUrl":"10.1007/s11682-024-00914-6","url":null,"abstract":"Resting state correlations between blood oxygenation level dependent (BOLD) MRI signals from voxels in white matter (WM) are demonstrably anisotropic, so that functional correlation tensors (FCT) may be used to quantify the underlying microstructure of BOLD effects in WM tracts. However, the overall spatial distribution of FCTs and their metrics in specific populations has not yet been established, and the factors that affect their precise arrangements remain unclear. Changes in WM occur with normal aging, and these may be expected to affect FCTs. We hypothesized that FCTs exhibit a characteristic spatial pattern and may show systematic changes with aging or other factors. Here we report our analyses of the FCT characteristics of fMRI images of a large cohort of 461 cognitively normal subjects (190 females, 271 males) sourced from the Open Access Series of Imaging Studies (OASIS), with age distributions of 42 y/o - 95 y/o. Group averages and statistics of FCT indices, including axial functional correlations, radial functional correlations, mean functional correlations and fractional anisotropy, were quantified in WM bundles defined by the JHU ICBM-DTI-81 WM atlas. In addition, their variations with normal aging were examined. The results revealed a dimorphic distribution of changes in FCT metrics with age, with decreases of the functional correlations in some regions and increases in others. Supplementary analysis revealed that females exhibited significant age effects on a greater number of WM areas, but the interaction between age and sex was not significant. The findings demonstrate the reproducibility of the spatial distribution of FCT metrics and reveal subtle regional changes with age.","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0