Brain Imaging and Behavior最新文献

{"title":"Parsing the heterogeneity of brain structure and function in male children with autism spectrum disorder: a multimodal MRI study.","authors":"Le Gao, Shuang Qiao, Yigeng Zhang, Tao Zhang, Huibin Lu, Xiaonan Guo","doi":"10.1007/s11682-025-00978-y","DOIUrl":"10.1007/s11682-025-00978-y","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a neurodevelopmental condition with high structural and functional heterogeneity. Multimodal fusion of structural and functional magnetic resonance imaging (MRI) allows better integration of ASD features from multiple perspectives. This study aimed to uncover the potential ASD subtypes by fusing the features of brain structure and function. An unsupervised learning method, similarity network fusion (SNF), was used. Resting-state functional MRI and structural MRI from the Autism Brain Imaging Data Exchange database of 207 male children were included in this study (105 ASD; 102 healthy controls (HC)). Gray matter volume (GMV) and amplitude of low-frequency fluctuation (ALFF) were utilized to represent structural and functional features separately. Structural and functional distance networks were constructed and fused by SNF. Then spectral clustering was carried out on the fused network. At last, the multivariate support vector regression analysis was used to investigate the relationship between the multimodal alterations and symptom severity of ASD subtypes. Two ASD subtypes were identified. Compared to HC, the two ASD subtypes demonstrated opposite GMV changes and distinct ALFF alterations. Furthermore, the alterations of ALFF predicted the severity of social communication impairments in ASD subtype 1. However, no significant associations were found between the multimodal alterations and symptoms in ASD subtype 2. These findings demonstrate the existence of heterogeneity with distinct structural and functional patterns in ASD and highlight the crucial role of combining multimodal features in investigating the neural mechanism underlying ASD.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"407-420"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive neural activation patterns in basketball athletes: insights from emotional processing using fMRI.","authors":"Yihan Wang, Yapeng Qi, Wenxuan Fang, Xinwei Li, Qichen Zhou, Jilan Ning, Jiaxin Du, Bin Zhang, Xiaoxia Du","doi":"10.1007/s11682-025-00987-x","DOIUrl":"10.1007/s11682-025-00987-x","url":null,"abstract":"<p><p>The impact of long-term exercise training on emotional processing remains unclear. This study investigated the neural activation patterns during emotional processing in collegiate basketball athletes compared to non-athletes. We utilized functional magnetic resonance imaging (fMRI) to examine 37 basketball athletes and 38 age- and gender-matched non-athletes while they performed the Emotional Faces Task and Intense Emotion Task. Participants' emotional states were assessed using various psychological questionnaires. In the Emotional Faces Task, athletes exhibited decreased activation in the left medial frontal gyrus, left paracentral lobule, and left cingulate gyrus when viewing neutral faces and increased activation in the right parahippocampal gyrus and right temporal lobe when viewing happy faces. In the Intense Emotion Task, the athletes exhibited increased activation in the left inferior frontal gyrus, left precentral gyrus, and right middle temporal gyrus when viewing fearful pictures. Conversely, they showed decreased activation in the bilateral medial frontal gyri, anterior cingulate cortex, bilateral rectus gyri, right middle occipital gyrus, right cuneus, and right cerebellum posterior lobe when viewing fearful pictures minus neutral pictures. Basketball athletes demonstrated distinct neural adaptations in emotional processing, suggesting a potential enhancement in performance and well-being under competitive stress. These findings contribute to understanding how long-term athletic training may influence brain function and emotional regulation.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"556-565"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating patterns of neuro-circuitry abnormalities in tremor dominant parkinson's disease and multiple system atrophy: a resting-state fMRI study.","authors":"Xiaolu Li, Huize Pang, Shuting Bu, Yingmei Li, Mengwan Zhao, Juzhou Wang, Yu Liu, Hongmei Yu, Guoguang Fan","doi":"10.1007/s11682-025-00984-0","DOIUrl":"10.1007/s11682-025-00984-0","url":null,"abstract":"<p><p>This study aimed to elucidate distinctive patterns of brain functional activity in tremor-dominant Multiple System Atrophy (MSA) and Parkinson's Disease (PD) patients and develop a diagnostic model distinguishing between the two conditions based on these changes. Resting-state fMRI data from 45 MSA patients, 55 PD patients, and 48 healthy controls were analyzed using Percent Amplitude of Fluctuation (PerAF), Functional (FC) and Effective Connectivity (EC) analyses. The Support Vector Machine (SVM) was used to create the diagnostic model from the identified functional alterations. Partial correlation analyses explored the relationship between functional abnormalities and tremors. Both MSA and PD patients with tremors exhibited similar activity changes in bilateral Orbital part of the superior frontal gyrus (ORBsup), Cerebellum VIII (CRBL8), left Cerebellum IV-V (CRBL45.L), right rectus (REC), and FC based on the seeds of PUT.L, CRBL8.R, and REC.R. These changes were more pronounced in MSA patients. However, MSA patients exhibited heightened putamen activity and enhanced EC from caudate (CAU) to putamen, whereas these activity and connectivity were decreased in PD patients. The SVM model achieved strong performance, with the putamen exerting the most significant influence on classification. In summary, dysfunction within the cerebello-cortical and basal ganglia network circuits is implicated in the tremors of both MSA and PD patients. The alteration in cerebellar-cortical regions were similar, with MSA displaying more pronounced changes, contrasting changes were observed in the basal ganglia region. The putamen may serve as crucial neurobiological indicators for the precise differentiation of MSA and PD patients.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"519-533"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neuroprotective power of artificial liver therapy: reversing cognitive impairment in minimal hepatic encephalopathy.","authors":"Xiaodong Wang, Xuhong Yang, Minglei Wang, Xueying Huang, Ming Zhang","doi":"10.1007/s11682-024-00947-x","DOIUrl":"10.1007/s11682-024-00947-x","url":null,"abstract":"<p><p>Alteration of functional connectivity in brain regions is one of the potential neuropathological mechanisms underlying cognitive impairment in patients with minimal hepatic encephalopathy (MHE). Artificial liver therapy has been shown to improve cognitive impairment in patients, suggesting a potential neuroprotective effect on the brain. This study investigates the impact of artificial liver therapy (AL) on cognitive impairment in patients with minimal hepatic encephalopathy (MHE) by examining alterations in brain functional connectivity. Resting-state functional magnetic resonance imaging (fMRI) data was collected from healthy controls and MHE patients before and after therapy. The MHE_post-AL group showed improved memory, reaction time, and executive function compared to the MHE_pre-AL group. Functional connectivity analysis revealed increased connectivity in specific brain regions in the MHE_pre-AL group compared to healthy controls, with subsequent decreased connectivity after therapy. Lower MoCA scores, higher blood ammonia levels, and lower cholinesterase levels were associated with higher functional connectivity in the MHE_pre-AL group. The study suggests that artificial liver therapy improves cognitive impairment in MHE patients, with changes in blood biochemistry mediating the link between functional connectivity and cognitive function. Correcting blood biochemistry levels may reverse abnormal brain connectivity and enhance cognitive function in MHE patients.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"497-507"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain function network and the risk of tinnitus: a bidirectional Mendelian randomization analysis.","authors":"Yuchao Liu, Chunli Li, Linli Yao, Yuan Tan, Lu Shi, Pei Chen","doi":"10.1007/s11682-025-00986-y","DOIUrl":"10.1007/s11682-025-00986-y","url":null,"abstract":"<p><strong>Objectives: </strong>Tinnitus affects millions worldwide. Its neural mechanisms remain unclear. This study aimed to explore the causal relationships between brain functional networks and tinnitus risk using Mendelian randomization (MR) analyses.</p><p><strong>Methods: </strong>We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.</p><p><strong>Results: </strong>Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10^-4). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10^-4). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).</p><p><strong>Conclusions: </strong>Specific brain activity and connectivity patterns are causally linked to tinnitus.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"456-467"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindful young brains and minds: a systematic review of the neural correlates of mindfulness-based interventions in youth.","authors":"Jovan Jande, Isaac N Treves, Samantha L Ely, Leah C Gowatch, Carmen Carpenter, MacKenna Shampine, Christian A Webb, Matthew D Sacchet, John D E Gabrielli, Hilary A Marusak","doi":"10.1007/s11682-025-00989-9","DOIUrl":"10.1007/s11682-025-00989-9","url":null,"abstract":"<p><p>This systematic narrative review examines neuroimaging studies that investigated the neural correlates of mindfulness-based interventions in youth (ages 0-18). We extracted 13 studies with a total of 467 participants aged 5-18 years from the MEDLINE database on February 21st, 2024. These studies included both typically developing youth and those at risk of developing or recovering from neuropsychiatric disorders. Most studies (76.9%) utilized a pre-post intervention design, with resting-state functional magnetic resonance imaging (fMRI) being the most common imaging modality (46.1%), followed by task-based fMRI (38.4%), diffusion-weighted imaging (15.4%), and structural MRI (7.7%). Despite substantial heterogeneity across study designs and findings, several consistent patterns emerged. Resting-state fMRI studies generally reported increased functional connectivity within and between networks, notably involving the salience network, frontoparietal network, and default mode network. Studies using diffusion-weighted imaging indicated enhancements in white matter microstructural properties, supporting overall connectivity improvements. Several task-based fMRI studies identified decreased activation of the default mode network and heightened reactivity of the salience network during or after mindfulness practice, with real-time neurofeedback further amplifying these effects. While preliminary, the reviewed studies suggest that mindfulness interventions may alter both functional and structural connectivity and activity in youth, potentially bolstering self-regulation and cognitive control. Nonetheless, the variability in methodologies and small sample sizes restricts the generalizability of these results. Future research should prioritize larger and more diverse samples, and standardized mindfulness-based interventions to deepen our understanding of the neural mechanisms underlying mindfulness-based interventions in youth and to optimize their efficacy.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"609-625"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults.","authors":"Arunima Kapoor, Jung Yun Jang, Allison C Engstrom, Trevor Lohman, Shubir Dutt, John Paul M Alitin, Isabel J Sible, Anisa Marshall, Fatemah Shenasa, Aimee Gaubert, Amy Nguyen, David Robert Bradford, Kathleen Rodgers, S Duke Han, Daniel A Nation","doi":"10.1007/s11682-025-00969-z","DOIUrl":"10.1007/s11682-025-00969-z","url":null,"abstract":"<p><p>Vascular Endothelial Growth Factor A (VEGF-A) is an angiogenic signaling protein involved in the maintenance of the cerebral vasculature. No prior study has explored whether plasma VEGF-A levels may be associated with brain functional connectivity changes, such as disruption of the default mode network (DMN), which often precedes the development of cognitive changes in aging. Seventy-six independently living older adults (mean age = 70.3 years; SD = 7.5; 31.6% male) free of dementia or clinical stroke underwent venipuncture and brain MRI. Plasma was assayed for VEGF-A. Using resting state functional MRI, region of interest (ROI) to ROI connectivity and graph theory analysis were conducted to determine average connectivity and global efficiency between each of the following ROIs comprising the DMN: medial prefrontal cortex, lateral parietal cortex and precuneus cortex. Multiple linear regression analysis revealed a significant negative association between VEGF-A levels and DMN connectivity (B = - 0.14, 95% CI (-0.26, - 0.01), p =.038), accounting for age, sex, education, and vascular risk factors. Graph theory analysis similarly revealed that VEGF-A levels are associated with global efficiency of the entire network (B = - 0.18, p =.004). These findings suggest that VEGF-A may be elevated early in the progression of neurocognitive disorders. Whether higher levels of VEGF-A contribute to the pathogenesis of neurocognitive disorders or play a protective role in preserving cognitive function warrants further investigation. Clinical Trial Number: N/A; None.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"379-383"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered brain glucose metabolism in COVID-19 disease: an activation likelihood estimation meta-analysis of PET studies.","authors":"Dongju Kang, Hyunji Jung, Kyoungjune Pak","doi":"10.1007/s11682-025-00966-2","DOIUrl":"10.1007/s11682-025-00966-2","url":null,"abstract":"<p><p>COVID-19 disease, caused by the SARS-CoV-2 virus, has significantly altered modern society and lifestyles. We investigated its impact on brain glucose metabolism by meta-analyzing existing studies that utilized 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans of the brain. We conducted a systematic search of MEDLINE and EMBASE databases from inception to August 2024 for English-language publications using the keywords \"positron emission tomography\", and \"COVID-19\". We included original research articles that reported changes in brain glucose metabolism following COVID-19 disease. ALE values from these studies were aggregated and tested against a null hypothesis that anticipated a random distribution of ALE values, which proved to be significantly higher than chance. We identified nine papers that met our inclusion criteria. Significant increases in brain glucose metabolism were noted in the left anterior cingulate gyrus, right thalamus, and brainstem. In children with COVID-19 disease, decreased glucose metabolism was observed in the right and left cerebellum, left amygdala/hippocampus, left anterior cingulate gyrus, and right amygdala. In adults with COVID-19 disease, decreased metabolism was seen in the right temporal lobe, brainstem (acute phase), left occipital lobe, left and right temporal lobe (chronic phase). In conclusion, COVID-19 disease impacts brain glucose metabolism, typically manifesting as areas of decreased metabolism in ¹⁸F-FDG PET scans, though increases are also observed. These changes in metabolism vary with the patient's age and the time elapsed between the diagnosis of COVID-19 disease and the PET scan.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"313-322"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring neuroanatomy and neuropsychology in digital financial decision-making: betrayal aversion and risk behavior.","authors":"Santiago Carbó-Valverde, Raquel Martín-Ríos, Francisco Rodríguez-Fernández","doi":"10.1007/s11682-025-00967-1","DOIUrl":"10.1007/s11682-025-00967-1","url":null,"abstract":"<p><p>Detecting the factors associated with financial decision-making is an unresolved challenge when trying to predict digital financial behavior. This paper reports experimental results on both neuropsychological and neuronal correlates of risk-taking and betrayal aversion among 121 healthy participants (X_age=21.7; SD = 2.8). A questionnaire on financial habits was administered, followed by neuropsychological tests and a magnetic resonance imaging session while participants viewed videos depicting both traditional and digital economic transactions. Participants also completed a computerized version of trust and risk games. Results reveal that Sensitivity to Punishment and Negative Urgency significantly predict risk behavior. High betrayal aversion was associated with greater sensitivity to punishment as well as lower volume in temporal areas. Cluster analysis identified two distinct psychological profiles based on betrayal aversion scores, highlighting differences in sensitivity to punishment, negative urgency, positive urgency, and trust game score. Furthermore, cortical thickness comparisons revealed differences between low and high-aversion groups, particularly in the temporal, parietal, and insular areas. White matter analysis indicated less integration in specific tracts among individuals with high betrayal aversion. These findings suggest the influence of neuropsychological factors on the adoption of risky financial behaviors and emotional response to betrayal.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"357-364"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal network connectivity and episodic memory in individuals aging with traumatic brain injury.","authors":"Catherine M Carpenter, Hollie A Mullin, Andrew Cwiek, Emily Carter, Samantha Vervoordt, Xinhui Lan, Nancy A Dennis, Amanda Rabinowitz, Umesh M Venkatesan, Frank G Hillary","doi":"10.1007/s11682-025-00979-x","DOIUrl":"10.1007/s11682-025-00979-x","url":null,"abstract":"<p><p>Aging is associated with marked declines in episodic memory corresponding with decreased volume in studies of morphology and reduced network response in studies of functional connectomics. Furthermore, recent research has demonstrated that reductions in resting state network connectivity are related to declines in episodic memory, specifically in the default mode and frontoparietal cortical networks. Additionally, the interactive effects of aging and traumatic brain injury (TBI) are associated with increased risk for neurodegeneration and episodic memory impairments. However, there is a gap in the literature examining episodic memory and hippocampal-subcortical resting state connectivity differences related to aging with and without TBI. The current work aims to investigate episodic memory differences between older adults with TBI (N = 45) and older adults with no history of TBI (N = 28) and how that relates to hippocampal-subcortical network differences at rest. We demonstrate a positive relationship between default mode and frontoparietal network connectivity and memory performance differentially between those aging with and without moderate-severe TBI (msTBI). Additionally, we demonstrate that reliability in the strength of resting state functional connectivity between parcellations is weakest among connections to the hippocampus compared to other cortical connections but is generally reliable across other connections.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"433-445"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}