Brain Imaging and Behavior最新文献

{"title":"Prediction modeling in transdiagnostic risk: results from the PROCAN study.","authors":"Mohammed K Shakeel, Zeyad Abouyoussef, Paul D Metzak, Roberto Souza, Xiangyu Long, Mike Lasby, Signe Bray, Benjamin I Goldstein, Glenda MacQueen, JianLi Wang, Sidney H Kennedy, Jean Addington, Catherine Lebel","doi":"10.1007/s11682-026-01173-3","DOIUrl":"10.1007/s11682-026-01173-3","url":null,"abstract":"<p><p>Identifying biomarkers for serious mental illnesses (SMI) has significant implications for early intervention and prevention. The current study uses machine learning to build a model of risk prediction and transition based on multi-modal neuroimaging, clinical, and behavioral data from youth at transdiagnostic risk. Participants aged 12-25 were recruited at two sites in Canada, and followed for 4 years. Symptom severity was measured using the Scale of Psychosis-Risk Symptoms (SOPS) and K10 Distress Scale, and a range of cognitive and behavioral measures were collected, as well as magnetic resonance imaging (MRI) data. Participants were assigned to one of 5 groups: healthy controls (HC; n = 42), familial risk (stage 0; n = 40), mild symptoms (stage 1a; n = 48), attenuated syndromes (stage 1b; n = 82), or discrete disorder (transition; n = 31). Constrained spherical deconvolution was used to generate whole brain tractography maps from diffusion MRI, which were then used to calculate connectivity matrices for graph theory analysis. Graph theory was also used to analyze correlations of functional MRI signal between pairs of brain regions. All measures were evaluated in a model to predict transition between groups. Random Forest analysis identified diffusion MRI-derived nodal metrics of betweenness centrality in the angular gyrus, inferior temporal gyrus, amygdala and calcarine fissure as potential features which can discriminate between the groups. Additionally, SOPS and K10 Distress Scales were useful behavioral predictors of transdiagnostic risk. Our findings show that combining neuroimaging with clinical characteristics may result in a promising predictive model for transdiagnostic risk and transition to SMI.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of association of the 5-HTTLPR polymorphism and brain serotonin transporter or receptor in healthy individuals: bayesian and frequentist meta-analyses.","authors":"You Min Hong, Si Jun Kim, Seon Been Yu, Kyoungjune Pak","doi":"10.1007/s11682-026-01178-y","DOIUrl":"10.1007/s11682-026-01178-y","url":null,"abstract":"<p><p>The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been linked to psychiatric disorders. This meta-analysis aimed to investigate the association between the 5-HTTLPR polymorphism and the availability of the serotonin transporter (SERT) or serotonin 1 A receptor (5-HT1AR), measured by positron emission tomography (PET) or single-photon emission computed tomography (SPECT). A systematic search was conducted to identify studies comparing SERT or 5-HT1AR availability by 5-HTTLPR genotype using PET or SPECT scans in healthy subjects. The standardized mean difference in SERT or 5-HT1AR availability between LL and S-carrier genotypes was calculated for each study in both frequentist and Bayesian meta-analyses. Eleven studies met the inclusion criteria. Pooled analysis showed no differences in SERT availability in the striatum, frontal lobe, brainstem, or thalamus between LL and S carriers of 5-HTTLPR. Similarly, no significant difference was observed in 5-HT1AR availability in the raphe nuclei between two genotypes. Bayesian meta-analysis confirmed that the standardized mean difference in SERT availability between LL and S carriers overlapped substantially with zero. In conclusion, the 5-HTTLPR polymorphism does not appear to affect the availability of SERT or 5-HT1AR in healthy individuals. This suggests that the relationship between 5-HTTLPR polymorphisms and psychiatric disorders is complex and that this polymorphism alone may not fully explain susceptibility.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of modifiable lifestyle factors on dementia subtypes and brain structural changes across KDIGO risk categories in the UK biobank.","authors":"Min Li, Li Yu, Wenbo Yang, Lijun Song, Mingan Li, Xiaoyan Bai, Zhenghan Yang, Zhenchang Wang, Han Lv, Hao Wang","doi":"10.1007/s11682-026-01170-6","DOIUrl":"10.1007/s11682-026-01170-6","url":null,"abstract":"<p><p>This study investigated the associations of modifiable lifestyle factors with incident dementia, dementia subtypes, and structural brain changes, examined whether these associations differed across KDIGO-defined kidney function risk categories. We analyzed 304,369 participants from the UK Biobank. Kidney function was classified using the KDIGO risk framework, with participants grouped into low- and increased-risk categories. A composite lifestyle score, derived from the American Heart Association Life's Essential 8 framework, was constructed based on eight modifiable components: diet quality, physical activity, smoking status, sleep duration, body mass index, blood lipid, blood glucose, and blood pressure. Outcomes included incident dementia and total and regional brain volumes. Among participants at increased KDIGO-defined risk, those in the intermediate and highest tertiles of the lifestyle score had a lower risk of dementia compared with those in the lowest tertile (hazard ratios, 0.826 [95% CI, 0.689-0.990] and 0.749 [95% CI, 0.585-0.958], respectively). Associations differed by dementia subtype: higher lifestyle scores were consistently associated with a lower risk of vascular dementia, whereas no overall association was observed with Alzheimer's disease. Higher lifestyle scores were also associated with larger total grey matter volume and greater volumes of subcortical structures, including caudate, pallidum, putamen, and thalamus, as well as lower volumes of total, deep, and periventricular white matter hyperintensities. Similar associations were observed in the low-risk group. A healthier lifestyle was associated with a lower risk of dementia, particularly vascular dementia, and with more favorable structural brain characteristics, with similar associations across KDIGO risk groups.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.","authors":"Yan Min, Zixiao Li, Lijun Zuo, Yongjun Wang","doi":"10.1007/s11682-026-01164-4","DOIUrl":"10.1007/s11682-026-01164-4","url":null,"abstract":"<p><p>Post-stroke cognitive impairment (PSCI) significantly impacts patients' quality of life following a stroke. Its effects on white matter functional networks remain unclear. This study used resting-state functional MRI to examine alterations in white matter functional connectivity and spontaneous activity in this condition. Resting-state functional MRI data were acquired from PSCI (n = 21), non-PSCI (PSNCI, n = 16), and healthy subjects (HSs, n = 29). A clustering analysis was employed to identify white matter functional networks. Functional connectivity and the amplitude of low-frequency fluctuation within these networks were compared across groups. Correlation analyses assessed their relationships with neuropsychological scores. Sixteen stable white matter networks were identified. Both patient groups showed reduced functional connectivity between the inferior longitudinal fasciculus and anterior cingulum compared to HSs. PSCI patients also exhibited decreased functional connectivity between the anterior and posterior cingulum compared to HSs. Furthermore, the amplitude of low-frequency fluctuation in the posterior cingulum was lower in PSCI group than in PSNCI group. These altered metrics showed correlations with neuropsychological performance across multiple cognitive domains. This study identified alterations in functional connectivity and spontaneous activity within specific WM networks in PSCI, which were associated with cognitive performance. These findings suggest that white matter functional abnormalities may be involved in the neural mechanisms underlying PSCI and could inform future research on early identification.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of acceptance and commitment therapy in major depressive disorder: a task-based fMRI study.","authors":"Sang Won Lee, Seungho Kim, Hyunsoo Kim, Yongmin Chang, Seung Jae Lee","doi":"10.1007/s11682-026-01166-2","DOIUrl":"10.1007/s11682-026-01166-2","url":null,"abstract":"<p><p>Acceptance and Commitment Therapy (ACT) has demonstrated effectiveness in treating Major Depressive Disorder (MDD); however, its underlying neural mechanisms remain poorly understood. Therefore, this study aims to investigate neural changes following an 8-week, group-based ACT intervention using task-based functional magnetic resonance imaging (fMRI) in patients diagnosed with MDD. Forty-two patients (21 in the ACT group and 21 in a waitlist control group) underwent fMRI scans before and after the intervention, using stimuli designed to evoke cognitive fusion alongside psychological assessments. The ACT group exhibited significant improvements in depressive symptoms and ACT-related psychological processes. fMRI analyses revealed increased posttreatment activation in brain regions central to emotion regulation, particularly the medial prefrontal cortex (mPFC) and anterior cingulate cortex. These neural changes were associated with improvements in depressive symptoms and reductions in cognitive fusion and experiential avoidance. Additionally, enhanced functional connectivity between the mPFC and posterior cingulate cortex/precuneus was observed, which was negatively correlated with rumination. These findings suggest that midline brain structures may serve as critical neural substrates for reducing ruminative thinking and enhancing cognitive defusion and acceptance, offering insights into the neurobiological mechanisms through which ACT exerts its antidepressant effects.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estradiol modulated brain connectivity in females during midlife performing an episodic memory task.","authors":"Abigail A Testo, Julie A Dumas","doi":"10.1007/s11682-026-01167-1","DOIUrl":"10.1007/s11682-026-01167-1","url":null,"abstract":"<p><p>Midlife in females typically involves a significant neuroendocrine transition that may have effects on brain connectivity that are relevant to both normal and pathological aging. One potential contributing factor to the individual differences in cognition and risk for pathological aging is the brain's response to decreased levels of estradiol. We assessed the relationship between estradiol level and task-modulated effective connectivity between brain regions during an episodic memory task in females during midlife. We utilized data from the Human Connectome Project - Aging 2.0 release. One hundred and fifty female participants between 40 and 55 years of age were included in our analysis of the relationship between estradiol and connectivity. Pre-, peri-, and postmenopausal participants were included to capture a range of estradiol levels present during midlife. We assessed connectivity during the fMRI FaceName task utilizing Conn Toolbox on a connection level as a pairwise comparison between regions. Five connections associated with estradiol were significant during the recall portion of the FaceName task at a p<.05 FDR corrected level after controlling for age. Significant connections among the superior frontal gyrus left and brain stem and the middle temporal gyrus anterior division right and superior temporal gyrus posterior division right were identified. Negative associations between these regions were also present. There was no significant relationship between estradiol and FaceName task performance. Our results indicated that task-modulated effective connectivity was related to estradiol level during midlife in females between brain regions known to be important for memory functioning during the recall portion of an episodic memory task. These findings may have long term implications for memory function in females during the aging process due to the low levels of estradiol present post-menopause.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime sports and exercise experience are associated with cognitive, social, and resting-state brain activity in adults.","authors":"Yi Zhou, Mie Matsui, Masashi Kinoshita, Daisuke Saito, Yuta Takiguchi, Kota Ebina, Mitsutoshi Nakada","doi":"10.1007/s11682-026-01168-0","DOIUrl":"10.1007/s11682-026-01168-0","url":null,"abstract":"<p><p>Sports/exercise engagement across the lifetime has been proposed to contribute to cognitive reserve and promote healthy brain aging. Few studies have examined whether past sports experiences are associated with current cognitive and social functions and resting-state brain activity in lifespan. The present study aimed to address that gap. Ninety healthy participants aged 20-83 years were categorized into four groups based on their self-reported sports experience: single sports (N = 25), team sports (N = 11), combined single and team sports (N = 20), and no experience (N = 34). We assessed cognitive function, social adaptation, and quality of life. Resting-state functional magnetic resonance imaging data were analyzed using amplitude of low-frequency fluctuations and seed-based functional connectivity to investigate local spontaneous activity and network-level integration. Participants with sports experience demonstrated enhanced performance in several cognitive tasks and higher social adaptation scores than those without experience. Neuroimaging analyses revealed increased amplitude of low-frequency fluctuations in the right middle frontal gyrus in the team-sport group. Furthermore, exploratory functional connectivity analysis showed reduced coupling between the right middle frontal gyrus and posterior sensory-visual regions, including the postcentral gyrus, lateral occipital cortex, and occipital fusiform gyrus. These findings suggest that lifetime sports engagement may be associated with differences in cognitive and psychosocial functioning, together with a tentative pattern of resting-state brain variation. Although the observed connectivity pattern may be broadly consistent with accounts of functional specialization or neural efficiency, the principal ALFF finding did not survive correction for multiple comparisons. Accordingly, the neuroimaging results should be regarded as preliminary and hypothesis-generating rather than confirmatory, while still providing a concrete basis for future hypothesis-driven investigation.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain network underlying social participation: a multimodal, data-driven investigation.","authors":"Mia G Casburn, Aodán Laighneach, Evie Doherty, Fergus Quilligan, Andrea Fernandes, Emma Corley, Gary Donohoe, Pilib Ó Broin, Derek W Morris, Dara M Cannon","doi":"10.1007/s11682-026-01165-3","DOIUrl":"10.1007/s11682-026-01165-3","url":null,"abstract":"<p><p>Identifying brain phenotypes influencing social participation may help understand social deficits in psychiatric disorders. Previous research shows methodological inconsistencies, lacking consensus on which brain regions are crucial. Data-driven variable selection may overcome this, facilitating unbiased replication and discovery of social brain regions. We compare data-driven selection to literature-identification of brain regions in explaining social participation variation. In 37,576 UK Biobank participants (mean age 65 ± 8, 53% female) with structural and functional neuroimaging data, social participation (range 0-10) was derived by combining leisure activity participation and friend/family visits. First, literature review identified a subset of brain regions previously associated with social measures. Secondly, recursive feature elimination selected a subset of imaging-derived phenotypes in 25% (n = 9,394) of the sample. Hierarchical regression in the remaining 75% (n = 28,152) compared whether data-selected or literature-identified brain phenotype-sets explained more variance in social participation. Individual p-values were corrected for multiple comparisons using the false discovery rate. Recursive feature elimination selected 198 imaging-derived phenotypes. Data-selected imaging-derived-phenotypes explained more variance in social participation (1.31%) than literature-identified (0.84%, F = 3.17, p < 0.0001). Seventeen imaging-derived-phenotypes were associated with social participation including mid-posterior-cingulate, inferior-frontal/orbital and insular thickness, and functional connectivity between pericentral with medial frontoparietal and cerebellar networks. Multi-modal brain imaging-derived phenotypes can predict small but significant variation in social participation. We confirmed previously identified social brain associations of pericentral and medial frontoparietal, and orbital regions while also implicating novel relationships with the insula, acoustic radiation, and lateral frontoparietal networks. This highlights the value of data-driven approaches in solidifying social brain regional involvement, outperforming literature-based methods, and revealing previously undetected relationships.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of homotopic functional connectivity and correlates with core neuropsychological impairments in mild cognitive impairment: a resting-state fMRI study.","authors":"Yunxiao Guo, Yujun Gao, Yinong Liu, Xinxiao Nie, Qian Xiong, Zhihong Ren","doi":"10.1007/s11682-026-01163-5","DOIUrl":"10.1007/s11682-026-01163-5","url":null,"abstract":"<p><p>Identifying individuals with mild cognitive impairment (MCI) who are at risk of progressing to Alzheimer's disease (AD) is crucial for early interventions and understanding disease mechanisms. While previous studies using resting-state fMRI (functional magnetic resonance imaging) have identified various neural markers in MCI, there is limited research on alterations in interhemispheric functional interactions. Fifty-three MCI patients and 68 age-, gender-, and education-matched healthy controls were included in the study. Structural cranial MRI and resting-state fMRI data were collected. We investigated voxel-mirrored homotopic connectivity (VMHC) alterations in patients with mild cognitive impairment (MCI) using resting-state fMRI. Functional connectivity was then calculated using the regions with abnormal VMHC as seed points. Correlation analyses were performed to examine the relationship between altered functional connectivity and Core Neuropsychological Test (CNT) scores. Compared to controls, MCI patients exhibited increased VMHC in the bilateral postcentral gyrus. Functional connectivity was enhanced between the bilateral postcentral gyrus and the left cerebellar Crus I, as well as the right inferior temporal gyrus. In contrast, decreased connectivity was observed with the left Gyrus rectus and right supplementary motor area. Correlation analysis revealed a significant negative relationship between VMHC values and CNT scores, as well as with verbal analogy and Chinese word matching scores. MCI patients not only show disrupted interhemispheric VMHC but also demonstrate significant associations with core neuropsychological impairments. These findings provide insights into cognitive changes in MCI and highlight potential biomarkers for early Alzheimer's disease detection.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal evaluation of hippocampal subfields volumes and episodic memory in breast cancer patients and healthy controls.","authors":"Baptiste Lerosier, Shailendra Segobin, Djelila Allouache, Sabine Noal, Christelle Levy, Ali R Khan, Bradley G Karat, Francois Christy, Florence Joly, Gael Chetelat, Francis Eustache, Bénédicte Giffard, Joy Perrier","doi":"10.1007/s11682-026-01162-6","DOIUrl":"10.1007/s11682-026-01162-6","url":null,"abstract":"<p><p>Despite previous reports of hippocampal alterations in breast cancer patients, the structural evolution of hippocampal subfields in relationship with memory remains to be characterized in this population. We aimed to measure hippocampal subfield volumes and their links with memory performances before and after chemotherapy in breast cancer patients compared to healthy controls. Forty-two middle aged women were evaluated, including 19 patients assessed before (T1), one-month (T2) and one-year (T3) after chemotherapy, and 23 controls assessed at T1 and T3. Using high-resolution MRI, hippocampal subfields were automatically segmented. Derived volumetric measures were compared between groups at T1 and T3 and within the patient group (T1, T2, T3). Both encoding and retrieval memory performances were measured using a dedicated task. At T1 and globally (i.e., T1 and T3 together), patients showed lower retrieval performance and larger subiculum and whole hippocampal volumes compared to controls. Volumes of the whole hippocampus and of the Cornu Ammonis (CA) 4-Dentate gyrus increased over time in controls. Longitudinal comparisons within the patients' group did not yield significant changes. Volumes were negatively associated with age in controls, and positively with education level in patients. Our results highlight structural differences in the subiculum and whole hippocampus of breast cancer patients both post-surgery and over the adjuvant treatment course. These modifications may reflect a combination of cancer-related and early perioperative factors, while the lack of subsequent longitudinal changes in patients prevents conclusions regarding the specific impact of chemotherapy. Additional studies with larger sample sizes will be of help to further our findings.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":"20 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}